Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3000322	10335	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	10335	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	10335	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	10335	38	None	-1	3	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	11693	8608	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	8608	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	8608	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	8608	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	8608	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	8608	16	None	-3	7	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	367	10596	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	5487427	10596	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	8592	10596	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL1900528	10596	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL3305968	10596	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	CHEMBL4650755	10596	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	DB01409	10596	12	None	-2	8	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
	3775	21247	26	None	-1	3	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201232	21247	26	None	-1	3	Human	8.0	pAC50	=	8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	1613	9127	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	9127	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	9127	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	9127	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	9127	53	None	-251	34	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2136	9869	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	9869	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	9869	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	9869	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	9869	30	None	-199	21	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	5280343	195054	124	None	-63	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL1520590	195054	124	None	-63	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL50	195054	124	None	-63	12	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	2247	7293	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	7293	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	7293	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	7293	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	7293	81	None	-323	42	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	4614	12163	103	None	-131	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	CHEMBL1071	12163	103	None	-131	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	293	5	1	3	4.0	O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1	10.1038/s41467-023-40064-9
	47936	200201	88	None	-97	6	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	200201	88	None	-97	6	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	180	7189	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	7189	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	7189	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	7189	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	7189	56	None	-309	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4940	21242	35	None	-18	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	21242	35	None	-18	15	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	5573	74355	92	None	-6	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1325297	74355	92	None	-6	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL190044	74355	92	None	-6	6	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	9	0	6	3.7	CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(c1ccccc1)N(C)C	10.1038/s41467-023-40064-9
	4919	213013	23	None	-5	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL86715	213013	23	None	-5	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	3316	38534	71	None	-22	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	38534	71	None	-22	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	21109	81774	75	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL203266	81774	75	None	-1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	5	1	5	1.1	COc1ccc(CN2CCNCC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	26248	168318	102	None	1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	168318	102	None	1	11	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	4413	104849	57	None	-3	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	104849	57	None	-3	15	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	9429	208912	58	None	-588	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	208912	58	None	-588	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3658	10879	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	10879	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	10879	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	10879	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	10879	53	None	-1258	18	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	2220	9908	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	9908	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	9908	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	9908	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	9908	82	None	-30	17	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	68873	50338	64	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	50338	64	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	443955	211149	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	211149	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	21158560	119570	7	None	-3090	2	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	CHEMBL3305985	119570	7	None	-3090	2	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1038/s41467-023-40064-9
	CHEMBL5292015	201316	0	None	-29	5	Human	7.8	pAC50	=	7.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
	41684	37995	105	None	-3	32	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	37995	105	None	-3	32	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	4477	43310	90	None	-12	4	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL1448	43310	90	None	-12	4	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	3	2	4	3.9	O=C(Nc1ccc([N+](=O)[O-])cc1Cl)c1cc(Cl)ccc1O	10.1038/s41467-023-40064-9
	5284550	48495	15	None	-74	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	48495	15	None	-74	16	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	3149	19386	15	None	-38	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	19386	15	None	-38	26	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	2333	149113	97	None	1	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	149113	97	None	1	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2713	212050	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	212050	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	212050	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	212050	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	212050	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	212050	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	212050	82	None	-28	27	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	154257	185398	67	None	-42	19	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	185398	67	None	-42	19	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	68617	212306	62	None	-18	30	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	212306	62	None	-18	30	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	212306	62	None	-18	30	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	216416	118358	48	None	-177	23	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	118358	48	None	-177	23	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	5048	9907	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	8924	9907	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	9948102	9907	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL462605	9907	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	DB11642	9907	64	None	-10000	5	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	8	0	2	4.2	Clc1ccc(cc1)CCCOCCCN1CCCCC1	10.1038/s41467-023-40064-9
	107771	127026	49	None	1	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL35228	127026	49	None	1	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	5803	169006	84	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	169006	84	None	-3	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	6127	21271	8	None	1	6	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	21271	8	None	1	6	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	72093	41835	9	None	-14	28	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	41835	9	None	-14	28	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	41835	9	None	-14	28	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	20628	103323	28	None	-40	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	103323	28	None	-40	13	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	447715	203706	68	None	-26	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	203706	68	None	-26	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	1024	8352	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	556	8352	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	9294	8352	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL211456	8352	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	DB01364	8352	27	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	13314	91008	15	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL22097	91008	15	None	-2	3	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	1	1	3	3.1	CN1C(=O)C(O)N=C(c2ccccc2Cl)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	4450	185007	69	None	-26	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	185007	69	None	-26	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	2335	18620	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	18620	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	18620	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	18620	22	None	-16	34	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	1816	9318	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	9318	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	9318	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	9318	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	9318	102	None	-2754	12	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4976	210358	29	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	210358	29	None	-123	15	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	46780481	114308	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	114308	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	114308	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	114308	20	None	-95499	15	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	5210	40112	48	None	-18	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1200765	40112	48	None	-18	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1419	40112	48	None	-18	8	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	47936	200201	88	None	-97	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	200201	88	None	-97	6	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	1530	8963	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	8963	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	8963	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	8963	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	8963	50	None	-63	25	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	1971	9641	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	9641	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	9641	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	9641	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	9641	38	None	-1023	32	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	3000322	10335	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	330	10335	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	CHEMBL569713	10335	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	DB00747	10335	38	None	-1	3	Human	7.7	pAC50	=	7.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
	3108	214066	116	None	1	7	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	214066	116	None	1	7	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	13789	45151	65	None	-1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL1463345	45151	65	None	-1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	0	0	3	4.4	C[C@]12CCC(=O)C=C1C=C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@]21CCC(=O)O1	10.1038/s41467-023-40064-9
	26987	7736	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	7736	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	7736	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	7736	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	7736	33	None	-204	34	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	213046	9164	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	9164	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	9164	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	9164	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	9164	59	None	-173	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	43815	193699	64	None	-10	20	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	193699	64	None	-10	20	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	193699	64	None	-10	20	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	3081361	100709	123	None	-33	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	100709	123	None	-33	14	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	100	10577	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	10577	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	10577	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	10577	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	10577	58	None	-89	38	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	1056	10144	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	10144	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	10144	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	10144	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	10144	116	None	-39	10	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	60753	201463	40	None	-6	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL533	201463	40	None	-6	6	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	187	7043	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	294	7043	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	65	7043	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	8593	7043	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL667	7043	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB03128	7043	39	None	-3	8	Human	7.7	pAC50	=	7.7	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	2131	64181	25	None	-3	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1652	64181	25	None	-3	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	3236	74383	43	None	-2	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1902981	74383	43	None	-2	7	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	4832	62194	17	None	-1	4	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1619528	62194	17	None	-1	4	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	5	1	3	3.1	CC[N+]1(C)CCCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1038/s41467-023-40064-9
	2705	10614	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	10614	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	10614	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	10614	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	10614	64	None	-1	9	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	124	9755	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	9755	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	9755	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	9755	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	9755	47	None	-11481	25	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2402	10143	62	None	-851	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	10143	62	None	-851	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	10143	62	None	-851	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	10143	62	None	-851	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	10143	62	None	-851	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	10184653	17769	107	None	-26	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	CHEMBL1173655	17769	107	None	-26	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	485	8	2	7	4.4	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	10.1038/s41467-023-40064-9
	127151	42104	18	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	3022645	42104	18	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	CHEMBL14370	42104	18	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	6	1	4	3.2	CCOc1ccccc1OC(c1ccccc1)C1CNCCO1	10.1038/s41467-023-40064-9
	19675	58444	43	None	-1862	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	58444	43	None	-1862	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	3949	107390	50	None	-25	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	107390	50	None	-25	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	54697325	65753	35	None	2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1689772	65753	35	None	2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
	25382	15929	37	None	-6	21	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	15929	37	None	-6	21	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	3158	63041	27	None	-891	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	63041	27	None	-891	28	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	1210	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	7705	51	None	-1047	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	5833	37257	74	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	CHEMBL1393	37257	74	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	2165	210562	71	None	-17	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	210562	71	None	-17	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	210562	71	None	-17	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	2564	212963	51	None	-239	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL864	212963	51	None	-239	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	6	0	3	3.4	CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	16363	7383	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	7383	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	7383	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	7383	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	7383	53	None	-501	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	10133	7697	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	145714624	7697	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	4361	7697	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	608	7697	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL240597	7697	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	DB06777	7697	78	None	-8	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	60606	68334	73	None	-13	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	68334	73	None	-13	8	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2726	7706	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	7706	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	7706	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	7706	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	7706	68	None	-794	42	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2333	149113	97	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	149113	97	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2895	210371	41	None	-38	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	210371	41	None	-38	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	31101	7516	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	7516	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	7516	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	7516	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	7516	40	None	-10232	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	131411	22164	70	None	-10	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	28446253	22164	70	None	-10	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	CHEMBL1214598	22164	70	None	-10	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	5591	164310	90	None	-13	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	164310	90	None	-13	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	2905	21270	50	None	-10	3	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1201338	21270	50	None	-10	3	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
	8612	18032	36	None	-7	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1179047	18032	36	None	-7	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	270	6	1	4	2.4	CCN(CC)CCOC(=O)c1ccc(N)cc1Cl	10.1038/s41467-023-40064-9
	2381	7450	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	374	7450	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	7128	7450	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1101	7450	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	DB00810	7450	48	None	-25	5	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1038/s41467-023-40064-9
	123603	7670	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	2684	7670	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	584	7670	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	9658	7670	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	CHEMBL168815	7670	29	None	-22	5	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1038/s41467-023-40064-9
	23480	130868	23	None	-4	7	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL363295	130868	23	None	-4	7	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	2286	9957	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	9957	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	9957	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	9957	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	9957	51	None	-19	28	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2551	7581	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	298	7581	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	488	7581	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL965	7581	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	DB00411	7581	23	None	-2	13	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	4942	12490	50	None	-4	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	12490	50	None	-4	11	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	135398745	9688	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	9688	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	9688	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	9688	112	None	-16	33	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	2166	9897	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	305	9897	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	5910	9897	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	CHEMBL550	9897	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	DB01085	9897	49	None	-28	10	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
	2370	7410	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	297	7410	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	358	7410	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	CHEMBL1482	7410	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	DB01019	7410	31	None	-19	3	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1038/s41467-023-40064-9
	319	8106	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	8106	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	8106	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	8106	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	8106	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	8106	44	None	-436	18	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	6450551	25983	106	None	1	3	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	CHEMBL1289926	25983	106	None	1	3	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	5	2	4	4.6	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1	10.1038/s41467-023-40064-9
	1427	8794	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	8794	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	8794	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	8794	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	8794	54	None	-1778	30	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2200	9905	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	328	9905	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	4848	9905	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	CHEMBL9967	9905	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	DB00670	9905	46	None	-114	10	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
	2540	11173	111	None	-660	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	11173	111	None	-660	28	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	124087	8171	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	8171	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	8171	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	8171	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	8171	114	None	-2	27	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2995	211184	53	None	-1737	18	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	211184	53	None	-1737	18	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	211184	53	None	-1737	18	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4746	211670	31	None	-4	19	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	211670	31	None	-4	19	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	211670	31	None	-4	19	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	11504295	9697	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	9697	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	9697	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	9697	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	9697	47	None	-38904	8	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2583	10548	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	10548	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	10548	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	10548	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	10548	118	None	-2884	16	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	103	10925	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	10925	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	10925	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	10925	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	10925	61	None	-489	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1224	8214	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	8214	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	8214	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	8214	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	8214	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	8214	83	None	-575	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	5453	210398	102	None	-13	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	210398	102	None	-13	14	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	3652	10869	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	10869	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	10869	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	10869	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	10869	79	None	-23	15	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	135	9310	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	9310	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	9310	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	9310	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	9310	43	None	-1047	33	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	5284632	74176	13	None	-1	4	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1888176	74176	13	None	-1	4	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3084748	74176	13	None	-1	4	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	154417	29953	60	None	-2	7	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1331216	29953	60	None	-2	7	Human	8.2	pAC50	=	8.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	2470	10425	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	10425	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	10425	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	10425	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	10425	50	None	-100000	23	Human	5.2	pAC50	=	5.2	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	71496458	122342	87	None	-1	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	122342	87	None	-1	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	657202	19302	6	None	-17	4	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1186610	19302	6	None	-17	4	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	54682461	91461	62	None	-1	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	91461	62	None	-1	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	154257	185398	67	None	-42	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	185398	67	None	-42	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	1385580	36049	76	None	-776	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	36049	76	None	-776	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	36049	76	None	-776	19	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	16351	109507	47	None	-309	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	109507	47	None	-309	17	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	4066	211405	78	None	-4	16	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	211405	78	None	-4	16	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4642	48760	28	None	-2	3	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL1495	48760	28	None	-2	3	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	2774	10640	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	5593	10640	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	7319	10640	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	CHEMBL1200604	10640	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB00809	10640	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	DB01199	10640	95	None	-19	5	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
	135398737	7745	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	7745	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	7745	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	7745	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	7745	93	None	-229	43	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	24826799	17570	104	None	-24	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	17570	104	None	-24	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	19861	214302	50	None	-3	10	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	214302	50	None	-3	10	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	4150	7575	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	7575	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	7575	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	7575	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	7575	39	None	-123	15	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	3294	8787	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	8787	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	8787	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	8787	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	8787	111	None	-4466	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	2337	10030	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	10030	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	10030	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	10030	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	10030	77	None	-177	29	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	3042	8196	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	8196	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	8196	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	8196	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	8196	35	None	-263	17	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	1201549	7384	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	7384	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	7384	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	7384	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	7384	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	7384	24	None	-26	26	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	24821094	73868	93	None	-4	8	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	73868	93	None	-4	8	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	636403	195047	22	None	-3	7	Human	5.0	pAC50	=	5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	195047	22	None	-3	7	Human	5.0	pAC50	=	5	Functional	Agonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAgonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	2267	7347	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	7347	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	7347	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	7347	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	7347	71	None	-416	14	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human CHRM2 in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	129456	213951	14	None	8	2	Human	10.4	pEC50	=	10.4	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	213951	14	None	8	2	Human	10.4	pEC50	=	10.4	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	10104167	8840	2	None	-1	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	6937	8840	2	None	-1	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL3121473	8840	2	None	-1	3	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
	42599070	22850	0	None	-251	5	Human	7.0	pEC50	=	7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223804	22850	0	None	-251	5	Human	7.0	pEC50	=	7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	370	4	0	3	4.1	CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	137630848	167895	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4061390	167895	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117131	167895	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
	10386	167947	16	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4092348	167947	16	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117554	167947	16	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
	2230	7253	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	296	7253	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	CHEMBL7303	7253	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	DB04365	7253	60	None	1	9	Human	5.0	pEC50	=	5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/s0960-894x(98)00509-5
	2551	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	298	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	488	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	CHEMBL965	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	DB00411	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assayAgonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as induction of Galphaq/i5-mediated IP1 accumulation after 1 hr by HTRF assay	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.8b01967
	49799920	17314	0	None	-6	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL1169506	17314	0	None	-6	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	11120503	10967	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100163	10967	0	None	-16	2	Human	6.0	pEC50	=	6.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	137629935	167799	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	167799	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	167799	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	44329977	118187	0	None	-10	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL327269	118187	0	None	-10	2	Human	8.0	pEC50	=	8.0	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.4	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2	10.1016/s0960-894x(98)00509-5
	44589681	192067	0	None	-1	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	CHEMBL485913	192067	0	None	-1	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	387	5	2	6	1.5	NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.032
	22745278	193842	1	None	-5	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	CHEMBL491209	193842	1	None	-5	5	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at muscarinic M2 receptorAgonist activity at muscarinic M2 receptor	ChEMBL	372	3	1	5	2.6	CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2008.09.023
	2551	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	298	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	488	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	CHEMBL965	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	DB00411	7581	23	None	-2	13	Human	7.0	pEC50	=	7.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00050a006
	10104047	28409	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	28409	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	137629935	167799	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	167799	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	167799	0	None	-1	3	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191002	130390	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	CHEMBL3618445	130390	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccccc1F	10.1016/j.bmcl.2015.08.011
	170332	167755	1	None	-2	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	167755	1	None	-2	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	167755	1	None	-2	3	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	3652	10869	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	57	10869	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	60809	10869	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	CHEMBL21536	10869	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	DB15357	10869	79	None	-23	15	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmcl.2015.08.011
	44303017	207612	0	None	-19	2	Human	5.9	pEC50	=	5.9	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60101	207612	0	None	-19	2	Human	5.9	pEC50	=	5.9	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	42598829	22852	0	None	-158	5	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223806	22852	0	None	-158	5	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	358	3	0	5	3.9	CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	45786849	164584	34	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4083241	164584	34	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
	44330073	215209	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL99884	215209	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	327	3	0	5	3.1	C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44209166	66330	0	None	7	2	Human	7.9	pEC50	=	7.9	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL171721	66330	0	None	7	2	Human	7.9	pEC50	=	7.9	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)	ChEMBL	193	1	0	4	1.0	Cc1noc(C2(C)CN3CCC2C3)n1	10.1021/jm00083a016
	44303408	208725	0	None	-16	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60777	208725	0	None	-16	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10451242	209893	0	None	-218	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL64029	209893	0	None	-218	3	Human	5.8	pEC50	=	5.8	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	122189496	130114	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616500	130114	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	499	5	2	3	5.4	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C(F)(F)F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	89777356	162661	0	None	-72	2	Human	5.8	pEC50	=	5.8	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4060475	162661	0	None	-72	2	Human	5.8	pEC50	=	5.8	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	353	3	2	6	2.5	Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	53385782	81088	0	None	-56	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	CHEMBL2024331	81088	0	None	-56	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human muscarinic M2 receptor by calcium mobilization assayAgonist activity at human muscarinic M2 receptor by calcium mobilization assay	ChEMBL	399	4	1	4	3.3	CCOC(=O)N1C2CCC1CC(N1CCC[C@@H](NC(=O)c3ccccc3C)C1)C2	10.1016/j.bmcl.2012.03.088
	424727	167953	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4095774	167953	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117601	167953	2	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	180	3	0	1	1.9	COc1ccccc1C[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	129456	213951	14	None	8	2	Human	7.7	pEC50	=	7.7	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	213951	14	None	8	2	Human	7.7	pEC50	=	7.7	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	24967746	22827	0	None	-50	5	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223754	22827	0	None	-50	5	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	403	5	1	4	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9820835	123553	4	None	-	1	Human	5.7	pEC50	=	5.7	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL337676	123553	4	None	-	1	Human	5.7	pEC50	=	5.7	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	179	2	1	5	0.1	CCn1nnc(C2=CCCNC2)n1	10.1021/jm00050a006
	9927975	10961	0	None	-10	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL100147	10961	0	None	-10	2	Human	8.7	pEC50	=	8.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	341	3	0	5	3.5	C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	145973726	171409	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	CHEMBL4216213	171409	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced responsePositive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response	ChEMBL	356	2	1	5	3.3	Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.10.053
	137629935	167799	0	None	-1	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	167799	0	None	-1	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	167799	0	None	-1	3	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191003	130391	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618446	130391	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	6	3	3	4.9	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	137635723	162862	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4062934	162862	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	411	3	2	9	2.5	Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	187	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	294	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	65	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	8593	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	CHEMBL667	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	DB03128	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2012.05.048
	187	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	294	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	65	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	8593	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	CHEMBL667	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	DB03128	7043	39	None	-3	8	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/jm100697g
	137630667	167871	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4100938	167871	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116890	167871	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	57230548	180012	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524085	180012	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	44330080	114497	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL319109	114497	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303018	208802	0	None	-218	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60833	208802	0	None	-218	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137631026	167929	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4093215	167929	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4117321	167929	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
	137628799	167772	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4064668	167772	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116150	167772	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189499	130115	0	None	3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	CHEMBL3616504	130115	0	None	3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	441	3	2	3	4.0	CN1CCCC/C1=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2	10.1016/j.bmcl.2015.08.011
	10686494	107314	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	CHEMBL291351	107314	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1016/s0960-894x(98)00509-5
	10686494	107314	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	CHEMBL291351	107314	0	None	-16	3	Human	6.6	pEC50	=	6.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
	122191007	130394	0	None	1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618449	130394	0	None	1	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	449	5	2	3	4.5	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(F)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	42598357	22877	0	None	-794	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223863	22877	0	None	-794	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	383	4	0	6	3.8	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42598359	22878	0	None	-199	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223864	22878	0	None	-199	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	436	5	0	7	3.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25207745	22898	0	None	-251	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223941	22898	0	None	-251	5	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	413	6	0	7	3.5	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	89777060	163900	0	None	-114	2	Human	5.6	pEC50	=	5.6	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4074908	163900	0	None	-114	2	Human	5.6	pEC50	=	5.6	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	397	3	2	7	2.5	Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	5487543	212425	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	CHEMBL81878	212425	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
	11725107	107389	0	None	-134	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL291872	107389	0	None	-134	3	Human	5.6	pEC50	=	5.6	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629887	167789	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4065555	167789	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4116259	167789	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
	10375002	30918	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	CHEMBL133905	30918	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	178	2	1	4	0.7	CCn1ncc(C2=CCCNC2)n1	10.1021/jm00050a006
	44158142	195449	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	CHEMBL503735	195449	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilizationAgonist activity at rat muscarinic M2 expressed in CHO cells assessed as stimulation of calcium mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1016/j.bmcl.2009.11.089
	5487543	212425	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	CHEMBL81878	212425	4	None	-162	6	Human	4.6	pEC50	=	4.6	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1016/s0960-894x(98)00509-5
	650899	61188	11	None	-10	5	Human	4.6	pEC50	=	4.6	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1535797	61188	11	None	-10	5	Human	4.6	pEC50	=	4.6	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	CHEMBL1609153	61188	11	None	-10	5	Human	4.6	pEC50	=	4.6	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	319	6	2	4	1.6	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2)CC1	nan
	44158142	195449	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	CHEMBL503735	195449	43	None	-1	4	Rat	5.6	pEC50	=	5.6	Functional	Activation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilizationActivation of rat muscarinic M2 receptor expressed in CHO cells co-expressing chimeric Gqi5 protein assessed as potentiation of acetylcholine-induced intracellular Ca2+ mobilization	ChEMBL	339	2	0	2	4.1	O=C1C(=O)N(Cc2ccc(C(F)(F)F)cc2)c2c(Cl)cccc21	10.1021/jm900286j
	57088082	180013	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL4524086	180013	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@@H]1CN2CCC[C@@H]1C2	10.1016/s0960-894x(98)00509-5
	53414666	166080	8	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4099673	166080	8	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
	178030	28143	31	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	CHEMBL131428	28143	31	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	5	0.4	CCn1nnc(C2=CCCN(C)C2)n1	10.1016/j.bmcl.2015.08.011
	129456	213951	14	None	8	2	Human	8.5	pEC50	=	8.5	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	CHEMBL92421	213951	14	None	8	2	Human	8.5	pEC50	=	8.5	Functional	In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)	ChEMBL	179	1	0	4	0.8	Cc1noc(C2CN3CCC2C3)n1	10.1021/jm00083a016
	137629935	167799	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	167799	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	167799	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	137629935	167799	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4060823	167799	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	CHEMBL4116342	167799	0	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
	122191006	130393	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618448	130393	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	523	6	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)CCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	3652	10869	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	57	10869	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	60809	10869	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	CHEMBL21536	10869	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	DB15357	10869	79	None	-23	15	Human	6.4	pEC50	=	6.4	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
	42598360	22876	0	None	-158	5	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223862	22876	0	None	-158	5	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	388	5	0	6	4.0	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	87934	104857	24	None	-	1	Human	6.4	pEC50	=	6.4	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL273308	104857	24	None	-	1	Human	6.4	pEC50	=	6.4	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	CHEMBL542883	104857	24	None	-	1	Human	6.4	pEC50	=	6.4	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00050a006
	122191004	130111	0	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616497	130111	0	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	521	7	3	4	4.7	COc1ccc(CCN/C(C)=N/c2ccc3c(c2)[C@@H](NC(=O)c2ccc(Br)cc2)[C@H](O)C3)cc1	10.1016/j.bmcl.2015.08.011
	122191001	130389	0	None	-9	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618444	130389	0	None	-9	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1cccc(F)c1	10.1016/j.bmcl.2015.08.011
	187	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	647412	34092	9	None	-3	4	Human	4.3	pEC50	=	4.3	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	CHEMBL1367424	34092	9	None	-3	4	Human	4.3	pEC50	=	4.3	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	325	6	2	5	1.7	CCOC(=O)N1CCC(NCCNC(=O)c2cccs2)CC1	nan
	187	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	137639541	163482	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	CHEMBL4070061	163482	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
	42598358	22874	0	None	-501	5	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223860	22874	0	None	-501	5	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	187	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	187	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	7043	39	None	-3	8	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44303293	208205	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60479	208205	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	53382542	93088	0	None	-7	6	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	CHEMBL2313377	93088	0	None	-7	6	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assayPositive allosteric modulation of human muscarinic M2 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
	187	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	294	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	65	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	8593	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL667	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB03128	7043	39	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	122191005	130392	0	None	-3	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618447	130392	0	None	-3	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	509	5	2	3	5.2	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	2551	7581	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	7581	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	7581	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	7581	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	7581	23	None	-2	13	Human	4.2	pEC50	=	4.2	Functional	Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	10426487	9616	7	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	291	9616	7	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	CHEMBL99521	9616	7	None	-3	2	Human	7.2	pEC50	=	7.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	10.1016/s0960-894x(98)00509-5
	306	10229	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	3536	10229	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	53930639	10229	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	9577995	10229	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	CHEMBL134641	10229	21	None	-1	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmcl.2015.08.011
	42598591	22849	0	None	-125	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223803	22849	0	None	-125	5	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	384	5	0	3	4.5	CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599068	22851	0	None	-199	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223805	22851	0	None	-199	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	356	3	0	3	3.7	CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	25230693	22897	0	None	-251	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223940	22897	0	None	-251	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	402	6	0	6	3.9	COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	16071018	22826	20	None	-112	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL1223753	22826	20	None	-112	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16038385	87233	0	None	-10	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	CHEMBL2146598	87233	0	None	-10	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	301	2	1	4	2.1	O=c1[nH]c2ccccc2n1C1CCN(C2CCOCC2)CC1	10.1021/ml100105x
	16123945	87234	12	None	-125	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	CHEMBL2146599	87234	12	None	-125	5	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	315	2	1	4	2.5	Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1	10.1021/ml100105x
	170332	167755	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	167755	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	167755	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	2166	9897	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	305	9897	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	5910	9897	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	CHEMBL550	9897	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	DB01085	9897	49	None	-28	10	Human	4.2	pEC50	=	4.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/s0960-894x(98)00509-5
	170332	167755	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	167755	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	167755	1	None	-2	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation after 10 mins by FRET assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	122189495	130113	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3616499	130113	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	445	5	2	3	4.7	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(C)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122191008	130395	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618450	130395	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	465	5	2	3	5.0	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H](O)C2)N(C)Cc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303397	109065	0	None	-75	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL303360	109065	0	None	-75	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	10104047	28409	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	28409	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	10019339	109403	0	None	-138	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL304247	109403	0	None	-138	3	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	5441	9204	10	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	9893054	9204	10	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL3616501	9204	10	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	507	6	2	3	6.1	O[C@@H]1Cc2c([C@H]1NC(=O)c1ccc(cc1)c1ccccc1)cc(cc2)N=C(N(Cc1ccc(cc1)F)C)C	10.1016/j.bmcl.2015.08.011
	187	7043	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	294	7043	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	65	7043	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	8593	7043	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	CHEMBL667	7043	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	DB03128	7043	39	None	-3	8	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2015.08.011
	2551	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	298	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	488	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	CHEMBL965	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	DB00411	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
	2551	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	298	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	488	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	CHEMBL965	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	DB00411	7581	23	None	-2	13	Human	6.2	pEC50	=	6.2	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00509-5
	59654579	130385	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618440	130385	0	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	495	5	3	3	4.8	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)NCc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	122190994	130382	0	None	-14	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	CHEMBL3618436	130382	0	None	-14	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	481	4	3	3	5.1	C/C(=N\c1ccc2c(c1)[C@@H](NC(=O)c1ccc(Br)cc1)[C@H](O)C2)Nc1ccc(F)cc1	10.1016/j.bmcl.2015.08.011
	44303294	207935	0	None	-16	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL60331	207935	0	None	-16	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	170332	167755	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	167755	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	167755	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44303286	208097	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL60419	208097	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsCompound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cells	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	44303286	208097	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	CHEMBL60419	208097	0	None	-48	3	Human	6.1	pEC50	=	6.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1016/s0960-894x(98)00509-5
	170332	167755	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4091934	167755	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4115997	167755	1	None	-2	3	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting methodAgonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [35S]GTPgammaS addition measured after 30 mins by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
	44253016	87232	2	None	-6	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	CHEMBL2146597	87232	2	None	-6	4	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells coexpressing Galpha16 subunit assessed as intracellular calcium mobilization after 10 to 15 mins by FLIPR assay	ChEMBL	299	2	1	3	3.3	O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1	10.1021/ml100105x
	44303019	107723	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL294082	107723	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	16071018	22826	20	None	-112	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223753	22826	20	None	-112	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	333	2	1	4	2.6	Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1	10.1016/j.bmcl.2010.07.097
	42598828	22875	0	None	-630	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223861	22875	0	None	-630	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	390	4	0	5	4.4	CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	42599071	22896	0	None	-316	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	CHEMBL1223939	22896	0	None	-316	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay	ChEMBL	450	6	0	7	3.8	CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1	10.1016/j.bmcl.2010.07.097
	9883040	107313	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL291339	107313	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL542622	107313	0	None	-7	3	Human	8.1	pEC50	=	8.1	Functional	In vitro functional agonism against M2 muscarinic receptor (cAMP)In vitro functional agonism against M2 muscarinic receptor (cAMP)	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44303396	208015	0	None	1	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL60374	208015	0	None	1	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	118500	163778	63	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	CHEMBL4073256	163778	63	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
	44303323	170021	0	None	-18	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	CHEMBL418491	170021	0	None	-18	3	Human	7.1	pEC50	=	7.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
	10104047	28409	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	CHEMBL131777	28409	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	M2 agonist activity estimated by depression of isolated guinea pig left atriumM2 agonist activity estimated by depression of isolated guinea pig left atrium	ChEMBL	192	3	1	4	0.9	C=CCn1ncc(C2CCCNC2)n1	10.1021/jm00050a006
	71792	85181	38	None	-2	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	CHEMBL2111051	85181	38	None	-2	5	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayAgonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay	ChEMBL	165	2	0	2	0.7	C#CCO[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.08.011
	44303327	169790	0	None	-31	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	CHEMBL417560	169790	0	None	-31	3	Human	6.1	pEC50	=	6.1	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
	2551	7581	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	298	7581	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	488	7581	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL965	7581	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	DB00411	7581	23	None	-2	13	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	44330081	214942	0	None	-17	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	CHEMBL98255	214942	0	None	-17	2	Human	8.1	pEC50	=	8.1	Functional	Stimulation of cAMP in CHO cells expressing human m2 receptorStimulation of cAMP in CHO cells expressing human m2 receptor	ChEMBL	325	3	0	5	2.8	C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2	10.1016/s0960-894x(98)00509-5
	44303314	107710	0	None	-363	3	Human	6.0	pEC50	=	6.0	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	CHEMBL293982	107710	0	None	-363	3	Human	6.0	pEC50	=	6.0	Functional	Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorCompound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptor	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
	137629744	167954	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4071109	167954	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	CHEMBL4117602	167954	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
	644390	47186	6	None	-3	4	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	CHEMBL1482157	47186	6	None	-3	4	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	353	6	2	4	2.3	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2Cl)CC1	nan
	25010776	62729	2	None	-44	5	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1559151	62729	2	None	-44	5	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	CHEMBL1624037	62729	2	None	-44	5	Human	4.0	pEC50	=	4.0	Functional	PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]PUBCHEM_BIOASSAY: Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2. (Class of assay: confirmatory) [Related pubchem assays: 626 (Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen), 1488 (Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Confirmation Assay)]	ChEMBL	333	6	2	4	1.9	CCOC(=O)N1CCC(NCCNC(=O)c2ccccc2C)CC1	nan
	137646732	164571	0	None	-12	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	CHEMBL4083081	164571	0	None	-12	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilizationActivity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization	ChEMBL	422	3	2	7	2.9	Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C	10.1016/j.bmcl.2017.05.014
	75356563	163736	23	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	CHEMBL4072787	163736	23	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting methodAgonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumulation after 2 hrs in presence of myo-[3H]inositol by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
	44372610	59317	0	None	181	2	Human	9.1	pED50	=	9.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL159208	59317	0	None	181	2	Human	9.1	pED50	=	9.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372301	56576	0	None	40	2	Human	8.7	pED50	=	8.7	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	CHEMBL156749	56576	0	None	40	2	Human	8.7	pED50	=	8.7	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	340	5	0	5	2.7	COc1ccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)cc1OC	10.1016/0960-894X(95)00087-A
	44372633	57082	0	None	-1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL157197	57082	0	None	-1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44372232	126598	0	None	-	0	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348412	126598	0	None	-	0	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	10058744	213161	0	None	1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL87622	213161	0	None	1	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372253	56784	0	None	21	2	Human	7.9	pED50	=	7.9	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156925	56784	0	None	21	2	Human	7.9	pED50	=	7.9	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	9795428	103263	5	None	-30	5	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	CHEMBL262455	103263	5	None	-30	5	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1	10.1021/jm960683m
	5487543	212425	4	None	-162	6	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	CHEMBL81878	212425	4	None	-162	6	Human	5.9	pED50	=	5.9	Functional	Amplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effectAmplification of transfected NIH3T3 cells was measured in Muscarinic acetylcholine receptor M2 required to produce half maximal effect	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
	10266025	126944	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL351561	126944	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372580	126559	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL348079	126559	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372492	162503	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL405426	162503	0	None	-	0	Human	8.6	pED50	=	8.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	314	3	0	3	3.3	C/C(C#Cc1ccc(Cl)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	7581	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	298	7581	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	488	7581	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	CHEMBL965	7581	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	DB00411	7581	23	None	-2	13	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/0960-894X(95)00087-A
	10420458	213047	0	None	7	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL86903	213047	0	None	7	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372591	61119	0	None	-60	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160858	61119	0	None	-60	2	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	286	3	0	4	2.8	C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372290	61225	0	None	-5	2	Human	6.6	pED50	=	6.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL160939	61225	0	None	-5	2	Human	6.6	pED50	=	6.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	2551	7581	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	298	7581	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	488	7581	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	CHEMBL965	7581	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	DB00411	7581	23	None	-2	13	Human	6.6	pED50	=	6.6	Functional	Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity expressed in IC50 labelled by [3H]QNB in CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm960683m
	44372254	60740	0	None	-	1	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL160554	60740	0	None	-	1	Human	7.6	pED50	=	7.6	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10086044	55752	0	None	6	2	Human	8.5	pED50	=	8.5	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL156050	55752	0	None	6	2	Human	8.5	pED50	=	8.5	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C/CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9903828	126271	0	None	28	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345415	126271	0	None	28	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372506	126247	0	None	19	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345205	126247	0	None	19	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	294	3	0	3	3.0	C/C(C#Cc1ccc(C)cc1)=C/CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372278	56184	0	None	11	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL156445	56184	0	None	11	2	Human	8.4	pED50	=	8.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	44372277	175142	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	CHEMBL434469	175142	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1cccc(C#C/C(C)=C/CO/N=C2\CN3CCC2C3)c1	10.1016/0960-894X(95)00087-A
	10242016	175078	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL434072	175078	0	None	-	0	Human	7.4	pED50	=	7.4	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372289	126254	0	None	-2	2	Human	6.3	pED50	=	6.3	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL345250	126254	0	None	-2	2	Human	6.3	pED50	=	6.3	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1/CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44213237	108698	0	None	-	0	Human	6.2	pED50	=	6.2	Functional	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	CHEMBL300998	108698	0	None	-	0	Human	6.2	pED50	=	6.2	Functional	Effective dose against affinity towards human muscarinic M2 receptorEffective dose against affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
	44372647	126798	0	None	-1	2	Human	8.1	pED50	=	8.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	CHEMBL350223	126798	0	None	-1	2	Human	8.1	pED50	=	8.1	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	310	4	0	4	2.7	COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1	10.1016/0960-894X(95)00087-A
	44371814	58173	0	None	3	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL158180	58173	0	None	3	2	Human	8.0	pED50	=	8.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	298	3	0	3	2.8	C/C(C#Cc1ccc(F)cc1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	44372452	126401	0	None	-	0	Human	6.0	pED50	=	6.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	CHEMBL346580	126401	0	None	-	0	Human	6.0	pED50	=	6.0	Functional	Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.Agonistic efficacy in human m2 muscarinic receptor expressed with the marker gene beta-galactosidase in NIH 3T3 cells.	ChEMBL	348	3	0	3	4.0	C/C(C#Cc1ccc(Cl)c(Cl)c1)=C\CO/N=C1\CN2CCC1C2	10.1016/0960-894X(95)00087-A
	9913341	88933	4	None	28	3	Human	9.3	pIC50	=	9.3	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL216927	88933	4	None	28	3	Human	9.3	pIC50	=	9.3	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL553058	88933	4	None	28	3	Human	9.3	pIC50	=	9.3	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44590172	177097	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444688	177097	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL527216	177097	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	591	10	3	6	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590171	185527	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL468609	185527	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554632	185527	0	None	1	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	587	10	3	6	4.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590176	195844	0	None	3	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509614	195844	0	None	3	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555707	195844	0	None	3	3	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	4.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(F)(F)F)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	155566290	183359	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4582879	183359	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4597498	183359	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
	11690968	113278	0	None	-5	3	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085072	113278	0	None	-5	3	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140185	113278	0	None	-5	3	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44590179	179496	0	None	1	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450538	179496	0	None	1	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553446	179496	0	None	1	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccccc2Cl)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590167	185803	0	None	-3	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL471214	185803	0	None	-3	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	494	10	4	6	2.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589495	192759	0	None	-10	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486982	192759	0	None	-10	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	5	7	3.8	CCCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590122	199339	0	None	-15	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL521244	199339	0	None	-15	3	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	555	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C#N)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16125400	91438	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222449	91438	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76313456	113286	0	None	-1	3	Human	6.0	pIC50	=	6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085066	113286	0	None	-1	3	Human	6.0	pIC50	=	6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140216	113286	0	None	-1	3	Human	6.0	pIC50	=	6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	162675053	190037	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4796491	190037	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
	71455968	90701	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206599	90701	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	10397133	113839	1	None	1	3	Human	6.0	pIC50	=	6.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL315676	113839	1	None	1	3	Human	6.0	pIC50	=	6.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71716773	93341	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	93341	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	162353372	188166	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4763422	188166	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
	71463135	90709	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206607	90709	0	None	-2	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	607	12	4	5	5.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71716773	93341	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL2315680	93341	0	None	2	2	Rat	6.0	pIC50	=	6.0	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	428	4	1	5	2.9	CCOC(=O)N1CCC(N2CCC[C@@H](NC(=O)c3ccc(C(F)(F)F)nc3)C2)CC1	10.1016/j.bmcl.2012.10.132
	109018479	188597	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	CHEMBL4778178	188597	1	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
	76327901	110272	0	None	1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085084	110272	0	None	1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1cccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)c1	10.1016/j.bmcl.2007.09.071
	44233675	110155	0	None	-11	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084639	110155	0	None	-11	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	381	5	0	1	6.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11518068	113283	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085059	113283	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140213	113283	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	44590180	179425	0	None	1	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL449640	179425	0	None	1	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540398	179425	0	None	1	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	641	10	3	6	5.2	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590175	195411	0	None	3	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL503025	195411	0	None	3	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553433	195411	0	None	3	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	3	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	52176747	165810	1	None	-2	8	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	165810	1	None	-2	8	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	162353379	187741	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4758449	187741	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
	25034111	200197	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL526009	200197	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44590123	190639	0	None	-15	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480877	190639	0	None	-15	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	564	10	4	6	4.3	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(Cl)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034111	200197	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL526009	200197	0	None	-7	3	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589497	182072	0	None	-5	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL457302	182072	0	None	-5	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	11	5	7	4.0	CC(C)COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44233417	92821	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2307674	92821	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	467	8	2	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10092649	199852	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	199852	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	10092649	199852	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	199852	56	None	-16	11	Rat	5.9	pIC50	=	5.9	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	290	9251	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	4022	9251	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	5926	9251	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL40554	9251	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	CHEMBL74300	9251	6	None	-21	5	Human	4.9	pIC50	=	4.9	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80538-7
	71450616	90708	0	None	-2	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206606	90708	0	None	-2	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	591	11	4	5	4.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1	10.1016/j.bmcl.2012.09.085
	11503336	113291	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085071	113291	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140242	113291	0	None	-5	3	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	76309756	110271	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085083	110271	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	375	4	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76313457	110268	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085080	110268	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	380	5	0	4	4.5	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	13940563	212809	5	None	5	2	Rat	5.9	pIC50	=	5.9	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL8510	212809	5	None	5	2	Rat	5.9	pIC50	=	5.9	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	182	2	0	3	-0.3	CN(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353393	186218	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	CHEMBL4740422	186218	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
	16664965	91677	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL223668	91677	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	76320693	110270	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085082	110270	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	109035013	187254	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	CHEMBL4752973	187254	1	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
	76309755	110266	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085079	110266	0	None	-1	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	76320692	113285	0	None	-5	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085065	113285	0	None	-5	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140215	113285	0	None	-5	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	390	4	0	3	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71459691	90707	0	None	5	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206605	90707	0	None	5	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	14	4	5	8.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	44590170	195150	0	None	1	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501348	195150	0	None	1	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL553431	195150	0	None	1	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	4	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(N)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	109032820	189654	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4791819	189654	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	162353369	187574	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756442	187574	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
	44232953	110168	0	None	-1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084663	110168	0	None	-1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	405	7	2	2	4.6	CCNC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	15681301	127098	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL352832	127098	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	3	0	3	0.7	C#CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	15945874	195544	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505452	195544	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	15945874	195544	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505452	195544	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589984	197337	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL518001	197337	0	None	-7	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590035	198533	0	None	-3	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL519760	198533	0	None	-3	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3OC)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034180	195191	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL502000	195191	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44589571	179366	0	None	-10	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448904	179366	0	None	-10	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	580	11	5	6	3.5	N#Cc1ccc(CN2CCC(NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)NCC4CC4)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589570	179536	0	None	-15	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL451040	179536	0	None	-15	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	568	10	5	6	3.5	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(C#N)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10465524	65770	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL169011	65770	0	None	-1	2	Human	4.8	pIC50	=	4.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	204	3	0	3	1.3	C=CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	167819	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	167819	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	167819	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	167819	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	137408729	197521	0	None	-870	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5182783	197521	0	None	-870	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	444	6	1	5	4.9	Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	15681299	127257	0	None	-1	2	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	CHEMBL354259	127257	0	None	-1	2	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	2	0	3	1.2	C1CC(O/N=C2\CN3CCC2C3)C1	10.1016/S0960-894X(00)80538-7
	156015978	185102	0	None	1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	185102	0	None	1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	185102	0	None	1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	10397356	127494	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL354738	127494	0	None	1	3	Human	5.8	pIC50	=	5.8	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	CC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	137630050	167819	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	167819	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	167819	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	167819	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	162353388	187758	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4758633	187758	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
	71459689	90691	0	None	1	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206585	90691	0	None	1	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	595	13	4	5	5.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	168276820	196885	0	None	-63	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	196885	0	None	-63	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	196885	0	None	-63	2	Human	5.8	pIC50	=	5.8	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	71454215	90700	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206595	90700	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	714	13	4	6	6.5	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCc2n(Cc3ccc(Cl)cc3)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	109013312	186913	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4748774	186913	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	162658112	187850	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4759774	187850	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	11602980	110279	0	None	-2	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085091	110279	0	None	-2	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	5	4.6	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	76324336	110274	0	None	-1	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085086	110274	0	None	-1	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	162353384	187869	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	CHEMBL4760037	187869	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
	71452455	90694	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206588	90694	0	None	-3	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	565	9	3	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	44590125	190640	0	None	-12	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480878	190640	0	None	-12	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	530	10	4	6	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccccc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590036	195156	0	None	-6	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL501419	195156	0	None	-6	3	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	574	10	4	8	3.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	152278786	189531	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	189531	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162646559	186419	0	None	-154	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4742997	186419	0	None	-154	4	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@@H](C)C1	10.1021/acsmedchemlett.0c00626
	25034112	195172	0	None	-1	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL501727	195172	0	None	-1	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	44589585	195671	0	None	-1	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507375	195671	0	None	-1	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555474	195671	0	None	-1	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	10	4	5	4.4	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590177	195701	0	None	3	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL507874	195701	0	None	3	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL554918	195701	0	None	3	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	677	12	3	7	5.1	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(C(=O)c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	163938	113695	13	None	316	2	Human	7.7	pIC50	=	7.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	CHEMBL314737	113695	13	None	316	2	Human	7.7	pIC50	=	7.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	180	1	1	5	0.1	Nc1noc(C2CN3CCC2C3)n1	10.1016/S0960-894X(00)80538-7
	152278786	189531	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	CHEMBL4790083	189531	1	None	-117	4	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	467	5	0	8	2.6	N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1	10.1021/acsmedchemlett.0c00626
	162353375	186674	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4745885	186674	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
	10262405	64370	0	None	-2	2	Human	4.7	pIC50	=	4.7	Functional	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166782	64370	0	None	-2	2	Human	4.7	pIC50	=	4.7	Functional	Compound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsCompound was evaluated for inhibitory activity for Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	206	3	0	3	1.5	CCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44234194	110173	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084670	110173	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	412	7	1	3	3.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(C)(=O)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10262466	105120	0	None	-10	2	Rat	6.7	pIC50	=	6.7	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL275104	105120	0	None	-10	2	Rat	6.7	pIC50	=	6.7	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	76324335	110269	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085081	110269	0	None	-1	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	428	4	0	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10399393	212565	0	None	1	2	Human	5.7	pIC50	=	5.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL83074	212565	0	None	1	2	Human	5.7	pIC50	=	5.7	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	162658421	187880	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4760150	187880	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	156015807	185078	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	185078	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	185078	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	76324334	113254	0	None	-15	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085070	113254	0	None	-15	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140112	113254	0	None	-15	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	369	4	0	3	4.5	Cc1ccoc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	156015978	185102	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4636899	185102	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651111	185102	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	138578683	191582	0	None	-1318	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	CHEMBL4851711	191582	0	None	-1318	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1	10.1021/acsmedchemlett.1c00363
	44265375	212926	0	None	-3	2	Rat	6.6	pIC50	=	6.6	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL8610	212926	0	None	-3	2	Rat	6.6	pIC50	=	6.6	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
	162353386	187759	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758635	187759	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	44233189	110178	0	None	1	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084678	110178	0	None	1	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	349	5	1	2	4.3	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	162667844	189312	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4787283	189312	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	44418764	88934	0	None	-1	4	Human	6.6	pIC50	=	6.6	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	CHEMBL216928	88934	0	None	-1	4	Human	6.6	pIC50	=	6.6	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
	44590033	190457	0	None	-12	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL480299	190457	0	None	-12	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(OC)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590166	196195	0	None	-3	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL513228	196195	0	None	-3	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	468	9	4	6	2.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(CC)C2)cc1	10.1016/j.bmcl.2008.09.020
	76316970	110263	0	None	-3	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085076	110263	0	None	-3	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	350	4	0	3	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	10220392	212784	0	None	-6	2	Human	4.6	pIC50	=	4.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL84893	212784	0	None	-6	2	Human	4.6	pIC50	=	4.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11508710	110277	0	None	-1	3	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085089	110277	0	None	-1	3	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2	10.1016/j.bmcl.2007.09.071
	156493644	191841	0	None	-1737	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4855467	191841	0	None	-1737	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	435	6	2	6	3.7	CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	156493614	192179	0	None	-338	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4860985	192179	0	None	-338	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	168272462	196943	0	None	-51	2	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5173887	196943	0	None	-51	2	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	428	6	1	5	4.4	Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	137630050	167819	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4089543	167819	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4097258	167819	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	CHEMBL4116470	167819	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
	46830362	14666	0	None	-5	5	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1090097	14666	0	None	-5	5	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	479	4	1	3	5.8	CCN1CCN(c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	76331543	110280	0	None	-2	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085092	110280	0	None	-2	3	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	362	4	0	4	4.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	193007	0	None	-870	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	193007	0	None	-870	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	193007	0	None	-870	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	9990434	113116	0	None	1	3	Human	5.6	pIC50	=	5.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL313918	113116	0	None	1	3	Human	5.6	pIC50	=	5.6	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44455159	104541	0	None	-25	5	Rat	4.5	pIC50	=	4.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL271704	104541	0	None	-25	5	Rat	4.5	pIC50	=	4.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	383	5	1	3	4.2	CCN1CCN(c2ccc(NC(=O)[C@H]3C[C@@H]3c3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	46682613	187935	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760823	187935	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
	162353378	189690	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4792360	189690	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
	44590174	176836	0	None	3	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL444300	176836	0	None	3	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL466271	176836	0	None	3	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	651	10	3	6	4.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Br)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590178	179517	0	None	1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450781	179517	0	None	1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540400	179517	0	None	1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	11583262	113274	0	None	-11	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085060	113274	0	None	-11	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140181	113274	0	None	-11	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	371	4	0	3	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156493565	191765	0	None	-1318	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4854289	191765	0	None	-1318	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	396	5	1	5	3.8	Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	168276820	196885	0	None	-63	2	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5172967	196885	0	None	-63	2	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	CHEMBL5208649	196885	0	None	-63	2	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	5	4.5	Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1	10.1016/j.bmcl.2021.128479
	10058347	112708	0	None	-2	2	Human	4.5	pIC50	=	4.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL312823	112708	0	None	-2	2	Human	4.5	pIC50	=	4.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71450615	90706	0	None	-1	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206604	90706	0	None	-1	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	609	14	4	5	5.5	CC[N+](CC)(CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Nc1ccc(C(=O)OC(C)C)cc1)Cc1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.085
	11819427	64326	0	None	-1	2	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166423	64326	0	None	-1	2	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	2	0	3	1.1	CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	47358375	187541	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4756164	187541	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
	11584660	100043	8	None	-1	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	CHEMBL244946	100043	8	None	-1	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic receptor M2Antagonist activity at human muscarinic receptor M2	ChEMBL	537	7	0	8	5.6	Cc1ccc2c(-c3nnc(SCCCN4CCc5ccc(-c6cc(C)nn6C)cc5CC4)n3C)cccc2n1	10.1021/jm0705612
	44590182	189930	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL479526	189930	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	532	9	5	7	3.0	COC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590034	196756	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL517087	196756	0	None	-12	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	11	4	7	3.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(OC)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094791	90032	0	None	-3	3	Human	5.5	pIC50	=	5.5	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL218755	90032	0	None	-3	3	Human	5.5	pIC50	=	5.5	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353374	186822	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4747590	186822	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	138578970	192446	0	None	-1862	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4864914	192446	0	None	-1862	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	414	5	1	5	4.0	Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	71452456	90711	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206609	90711	0	None	-2	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	525	10	4	5	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(C)CCCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	122203596	162585	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	162585	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	162585	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 0.1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	137637944	162594	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4059829	162594	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	450	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	71450617	90712	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206610	90712	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	527	12	4	5	4.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2012.09.085
	162353382	188513	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	CHEMBL4777127	188513	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
	11626847	113253	0	None	-9	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085068	113253	0	None	-9	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140111	113253	0	None	-9	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccsc1CN(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]2(C)C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	2551	7581	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	298	7581	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	488	7581	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	CHEMBL965	7581	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	DB00411	7581	23	None	-2	13	Human	5.5	pIC50	=	5.5	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(00)80538-7
	10092649	199852	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	199852	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	44233419	110176	0	None	-1	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	CHEMBL3084674	110176	0	None	-1	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	376	6	1	2	4.4	CC(=O)NCC(C[C@@H]1C[C@@H]2CC[C@H](C1)N2C)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2009.07.006
	10092649	199852	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	CHEMBL522460	199852	56	None	-43	11	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium responseAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1016/j.bmcl.2012.10.132
	164606754	191481	7	None	-954	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	191481	7	None	-954	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	191481	7	None	-954	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	138578253	193234	0	None	-1230	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	CHEMBL4876599	193234	0	None	-1230	2	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	378	5	1	5	3.7	c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1	10.1021/acsmedchemlett.1c00363
	24882532	101892	0	None	-7	4	Rat	5.5	pIC50	=	5.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255523	101892	0	None	-7	4	Rat	5.5	pIC50	=	5.5	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	137638270	163656	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	CHEMBL4071900	163656	0	None	-3	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells co-transfected with Gqi5 in presence of EC80 acetylcholine by calcium mobilization assay	ChEMBL	434	4	0	8	2.2	Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1	10.1016/j.bmcl.2017.05.042
	137647734	164625	0	None	-2	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4083681	164625	0	None	-2	5	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	448	4	0	5	4.7	O=C(C1CCN(c2cc(Oc3ccc(Cl)cc3)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	156016041	185026	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	185026	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	185026	0	None	-1	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	122203596	162585	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	162585	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	162585	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 10 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	76327903	110281	0	None	-4	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085093	110281	0	None	-4	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	381	4	0	5	4.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccc(C#N)cc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	69444105	110264	0	None	-1	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085077	110264	0	None	-1	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015807	185078	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641726	185078	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650973	185078	0	None	1	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	137655063	165752	0	None	-3	5	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096143	165752	0	None	-3	5	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	432	4	0	5	4.2	O=C(C1CCN(c2cc(Oc3ccccc3F)ncn2)CC1)N1CCc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	11552174	110278	0	None	-3	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085090	110278	0	None	-3	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	44589583	179260	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448294	179260	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555471	179260	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	561	10	5	6	3.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590168	179508	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL450652	179508	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540399	179508	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	4	7	3.6	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44589584	195558	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL505651	195558	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540144	195558	0	None	-6	3	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	563	10	4	5	4.0	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc(F)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16094788	148693	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL386983	148693	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	162353381	186808	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	CHEMBL4747438	186808	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
	44589498	179537	0	None	-3	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL451043	179537	0	None	-3	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	572	11	5	7	3.8	O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1	10.1016/j.bmcl.2008.09.020
	10419574	64869	0	None	2	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL167438	64869	0	None	2	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	168	3	0	3	1.1	CCCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	76327900	113260	0	None	-12	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085061	113260	0	None	-12	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140142	113260	0	None	-12	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71457771	90704	0	None	-5	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206602	90704	0	None	-5	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	691	14	4	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc(Cl)cc2)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	76320694	110273	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085085	110273	0	None	-1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	370	4	0	4	4.8	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	71454213	90697	0	None	11	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206591	90697	0	None	11	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	723	11	3	5	7.0	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCc4ccccc4C3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	71450662	90781	0	None	1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207176	90781	0	None	1	3	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	611	13	4	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCCC[N+](C)(C)Cc2ccc3ccccc3c2)cc1	10.1016/j.bmcl.2012.09.085
	162649767	186881	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4748337	186881	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
	71452454	90693	0	None	-41	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206587	90693	0	None	-41	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	603	9	3	7	3.9	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4c(c3)OCO4)CC2)cc1	10.1016/j.bmcl.2012.09.085
	54816802	188051	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4762056	188051	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	10081053	64344	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166593	64344	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	182	1	0	3	1.5	CC(C)(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44233187	92800	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2306159	92800	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	474	8	1	3	5.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNS(=O)(=O)c1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	76327902	110276	0	None	-1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085088	110276	0	None	-1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	354	4	0	4	4.4	Cc1ccoc1CN(C(=O)O[C@H]1C[C@@H]2CC[C@H](C1)N2C)c1ccccc1	10.1016/j.bmcl.2007.09.071
	164606754	191481	7	None	-954	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4850236	191481	7	None	-954	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873617	191481	7	None	-954	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	432	5	1	5	4.1	Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	109035056	188102	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	CHEMBL4762755	188102	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
	11619198	113268	0	None	-10	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085058	113268	0	None	-10	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140170	113268	0	None	-10	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	365	4	0	2	4.6	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	156015153	185086	0	None	1	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	185086	0	None	1	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	185086	0	None	1	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	162353371	188429	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4775999	188429	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
	16040727	176222	0	None	2	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL442672	176222	0	None	2	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL495102	176222	0	None	2	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	649	11	3	6	5.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(-c3ccccc3)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590169	195022	0	None	7	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL499565	195022	0	None	7	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL539885	195022	0	None	7	3	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	603	11	3	7	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	44590181	180343	0	None	12	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL453248	180343	0	None	12	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL551113	180343	0	None	12	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	633	12	3	8	3.9	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(OC)c(OC)c2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	25034110	195545	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	CHEMBL505453	195545	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	546	10	5	7	3.4	CCOC(=O)c1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCN(Cc3ccc(O)cc3)C2)cc1	10.1021/jm800634k
	10376012	65507	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168561	65507	0	None	1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	216	2	0	3	1.1	CC#CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	76320690	113237	0	None	-2	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085063	113237	0	None	-2	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140092	113237	0	None	-2	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1cccc(Br)c1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	137654353	165795	0	None	-1	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	CHEMBL4096589	165795	0	None	-1	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assayAntagonist activity at recombinant human M2 receptor expressed in CHO cells co-expressing Gqi5 by calcium mobilization assay	ChEMBL	436	4	0	5	4.3	O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1Cc2ccccc2C1	10.1016/j.bmcl.2017.04.009
	2986945	101830	7	None	-47	5	Rat	4.3	pIC50	=	4.3	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	CHEMBL255169	101830	7	None	-47	5	Rat	4.3	pIC50	=	4.3	Functional	Antagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor expressed in CHO cells by calcium mobilization assay	ChEMBL	371	6	1	3	4.1	CCN1CCN(c2ccc(NC(=O)CCc3ccccc3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
	2904292	190359	13	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4800495	190359	13	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
	15681300	64337	0	None	-1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL166537	64337	0	None	-1	2	Human	5.3	pIC50	=	5.3	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	178	2	0	3	0.7	C#CC(C)O/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	11510358	113261	0	None	-4	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085069	113261	0	None	-4	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140143	113261	0	None	-4	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	355	4	0	3	4.2	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	58975257	110154	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084638	110154	0	None	-1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	377	6	2	2	3.9	CN1[C@H]2CC[C@@H]1C[C@H](CC(CNC(N)=O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	36014865	189449	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	CHEMBL4789054	189449	2	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
	44233928	92849	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2308786	92849	0	None	1	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPRAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR	ChEMBL	438	7	1	2	5.6	CN1[C@H]2CC[C@@H]1C[C@H](CC(C(=O)NCc1ccccc1)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	71455969	90705	0	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206603	90705	0	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	581	12	4	5	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11547053	113242	0	None	-9	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085074	113242	0	None	-9	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140097	113242	0	None	-9	3	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	3	5.0	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	71454217	90703	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206601	90703	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	551	9	3	5	4.3	CC[N+]1(C2CCN(C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)CC2)CCCC1	10.1016/j.bmcl.2012.09.085
	109014373	186581	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	CHEMBL4744856	186581	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
	156016041	185026	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4644612	185026	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4650627	185026	0	None	-1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	71455966	90696	0	None	2	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206590	90696	0	None	2	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	675	11	3	5	6.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC3CCCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	52176747	165810	1	None	-13	8	Rat	5.2	pIC50	=	5.2	Functional	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	CHEMBL4096727	165810	1	None	-13	8	Rat	5.2	pIC50	=	5.2	Functional	Antagonist activity at rat muscarinic M2 receptor by calcium mobilization assayAntagonist activity at rat muscarinic M2 receptor by calcium mobilization assay	ChEMBL	435	4	0	6	3.0	C[C@H]1CCCCN1c1ccc(N2CCN(S(=O)(=O)c3ccccc3Cl)CC2)nn1	10.1016/j.bmcl.2017.05.042
	15681303	65764	0	None	-1	2	Human	4.2	pIC50	=	4.2	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168991	65764	0	None	-1	2	Human	4.2	pIC50	=	4.2	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	208	3	0	4	0.3	COCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	44590173	195870	0	None	1	3	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL510029	195870	0	None	1	3	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555019	195870	0	None	1	3	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	607	10	3	6	4.5	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@H]2CC[N+](C)(Cc3ccc4c(c3)OCO4)C2)cc1	10.1016/j.bmcl.2008.09.020
	156015153	185086	0	None	1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4641714	185086	0	None	1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	CHEMBL4651018	185086	0	None	1	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 22 degree C pre-incubated for 180 mins followed by carbachol addition and further incubated at 37 degree C for 90 mins by HTRF assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
	11712408	113299	0	None	-3	3	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085067	113299	0	None	-3	3	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140261	113299	0	None	-3	3	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	385	4	0	3	5.0	Cc1ccc(CN(C(=O)O[C@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)s1	10.1016/j.bmcl.2007.09.071
	108993425	188537	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4777543	188537	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	168289751	198589	0	None	-47	2	Human	5.2	pIC50	=	5.2	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	CHEMBL5198423	198589	0	None	-47	2	Human	5.2	pIC50	=	5.2	Functional	Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assayInhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay	ChEMBL	446	6	1	7	4.0	Cn1cc2cc(-c3ccc(NC[C@@H]4CC45CCN(CC4CCOCC4)CC5)nn3)ccc2n1	10.1016/j.bmcl.2021.128479
	2551	7581	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	298	7581	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	488	7581	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	CHEMBL965	7581	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	DB00411	7581	23	None	-2	13	Human	7.2	pIC50	=	7.2	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
	1201549	7384	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	333	7384	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	7601	7384	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL1201203	7384	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	CHEMBL438151	7384	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	DB00245	7384	24	None	-26	26	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/acsmedchemlett.0c00626
	44590124	176573	0	None	-39	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL443925	176573	0	None	-39	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	598	10	4	6	4.7	CCOC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3cccc(C(F)(F)F)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	162657046	187622	0	None	-99	4	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	CHEMBL4757103	187622	0	None	-99	4	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 minsAntagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubated for 30 mins	ChEMBL	406	5	0	4	4.1	Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1	10.1021/acsmedchemlett.0c00626
	76316969	113300	0	None	-11	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085075	113300	0	None	-11	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140262	113300	0	None	-11	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	396	4	0	4	4.5	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1cccc(C#N)c1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	162353391	187600	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	CHEMBL4756873	187600	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
	76313454	113284	0	None	-1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085064	113284	0	None	-1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140214	113284	0	None	-1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	443	4	0	2	5.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccccc1Br)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	138578326	193007	0	None	-870	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4861863	193007	0	None	-870	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	CHEMBL4873386	193007	0	None	-870	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	430	5	1	5	4.5	Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1	10.1021/acsmedchemlett.1c00363
	76309754	113298	0	None	-8	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3085062	113298	0	None	-8	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	CHEMBL3140260	113298	0	None	-8	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	395	5	0	3	4.6	COc1ccc(CN(C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)[N+]3(C)C)c2ccccc2)cc1	10.1016/j.bmcl.2007.09.071
	1421986	15037	4	None	-2	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	CHEMBL1092461	15037	4	None	-2	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilizationAntagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylcholine-induced calcium mobilization	ChEMBL	357	4	1	3	4.0	CCN1CCN(c2ccc(NC(=O)c3ccc(C)cc3)cc2Cl)CC1	10.1016/j.bmcl.2010.02.041
	11442478	113255	0	None	-7	3	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085073	113255	0	None	-7	3	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3140113	113255	0	None	-7	3	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	377	4	0	4	4.7	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2	10.1016/j.bmcl.2007.09.071
	10109893	88940	0	None	89	3	Human	8.1	pIC50	=	8.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL216983	88940	0	None	89	3	Human	8.1	pIC50	=	8.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	CHEMBL544840	88940	0	None	89	3	Human	8.1	pIC50	=	8.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
	162353376	187206	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4752380	187206	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
	11820032	105000	0	None	1	2	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	CHEMBL274329	105000	0	None	1	2	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
	162353377	187944	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4760904	187944	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
	162353390	187728	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	CHEMBL4758316	187728	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
	162670602	189716	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4792675	189716	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
	133640439	188152	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	CHEMBL4763304	188152	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
	10240891	212877	0	None	1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL85678	212877	0	None	1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	16094783	143345	0	None	12	3	Human	7.1	pIC50	=	7.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	CHEMBL373888	143345	0	None	12	3	Human	7.1	pIC50	=	7.1	Functional	Activity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulationActivity at human M2 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
	44589496	192760	0	None	-15	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL486983	192760	0	None	-15	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	560	10	5	7	3.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NC2CCN(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	174174	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	260	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	320	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	CHEMBL517712	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	DB00572	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation at 37 degree C pre-incubated for 30 mins followed by carbachol addition and measured after 60 mins by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
	174174	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	260	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	320	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	CHEMBL517712	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	DB00572	7311	49	None	-6	7	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.8b01967
	76309757	110275	0	None	-1	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085087	110275	0	None	-1	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	340	4	0	4	4.0	CN1[C@H]2CC[C@@H]1C[C@@H](OC(=O)N(Cc1ccoc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	71463136	90710	0	None	-2	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206608	90710	0	None	-2	3	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	12	4	5	5.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1	10.1016/j.bmcl.2012.09.085
	71459724	90782	0	None	-63	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2207177	90782	0	None	-63	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]([N+](C)(C)Cc3ccc(Cl)cc3)C2)cc1	10.1016/j.bmcl.2012.09.085
	302	9751	25	None	-7	8	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	4630	9751	25	None	-7	8	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	CHEMBL7634	9751	25	None	-7	8	Rat	7.1	pIC50	=	7.1	Functional	Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nMMuscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radioligand as a M2 non-selective muscarinic receptor antagonist at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
	122203596	162585	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4059733	162585	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	CHEMBL4066481	162585	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Competitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assayCompetitive antagonist activity at human muscarinic acetylcholine receptor M2 expressed in HEK293 cells coexpressing HA tagged Galpha-protein qi5 assessed as inhibition of 1 uM carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition measured after 1 hr by HTRF assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
	71454214	90698	0	None	1	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206592	90698	0	None	1	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	573	10	3	5	4.2	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(CCc3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10375322	65504	0	None	-1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168545	65504	0	None	-1	3	Human	5.1	pIC50	=	5.1	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	192	2	0	3	1.1	CCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71454212	90692	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206586	90692	0	None	5	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	623	13	4	5	5.8	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC(C)(C)C[N+](C)(C)Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	16125704	91439	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL222450	91439	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardiaActivity at muscarinic M2 receptor in Albino Dunkin-Hartley guinea pig left atria assessed as inhibition of methacholine-induced bradycardia	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
	CHEMBL4755618	220820	39	None	1	2	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at muscarinic M2 receptor (unknown origin)Agonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL		None	None	None		Cc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12	10.1021/acs.jmedchem.1c02148
	11617374	110265	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	CHEMBL3085078	110265	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilizationAntagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization	ChEMBL	356	4	0	4	4.5	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2	10.1016/j.bmcl.2007.09.071
	155522355	183188	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4451030	183188	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	CHEMBL4596065	183188	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assayAntagonist activity at human muscarinic M2 receptor expressed in HEK293 cells co-expressing HA-Galphaq/i5 assessed as inhibition of carbachol-induced IP1 accumulation pre-incubated for 30 mins followed by carbachol addition and measured after 1 hr by HTRF assay	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
	49665121	177242	11	None	3	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	CHEMBL4448840	177242	11	None	3	3	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseAntagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response	ChEMBL	384	4	0	8	3.4	Fc1cc(F)cc(-c2nnc(Cc3nc(-c4ccc5c(c4)OCO5)no3)o2)c1	10.1016/j.bmcl.2016.07.071
	162353387	188010	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	CHEMBL4761549	188010	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
	71457770	90702	0	None	-1	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206600	90702	0	None	-1	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	647	10	3	5	6.1	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC([N+]3(Cc4ccc(Cl)cc4)CCCC3)CC2)cc1	10.1016/j.bmcl.2012.09.085
	10376182	65530	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	CHEMBL168639	65530	0	None	-1	2	Human	5.0	pIC50	=	5.0	Functional	Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cellsInhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells	ChEMBL	220	4	0	3	1.9	CCCCC#CCO/N=C1\CN2CCC1C2	10.1016/S0960-894X(00)80538-7
	71455965	90695	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206589	90695	0	None	-3	3	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	621	10	3	5	5.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(C(C)C)CC2)cc1	10.1016/j.bmcl.2012.09.085
	162353383	189356	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	CHEMBL4787944	189356	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
	162657652	187764	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	CHEMBL4758742	187764	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholineAntagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
	71463134	90699	0	None	-2	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	CHEMBL2206594	90699	0	None	-2	2	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	618	11	3	6	4.7	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N(C)Cc2n(C)cc[n+]2Cc2ccc(Cl)cc2)cc1	10.1016/j.bmcl.2012.09.085
	11519069	10711	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	11519070	10711	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	4816	10711	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	7354	10711	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	CHEMBL1187833	10711	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	DB09076	10711	3	None	1	3	Human	10.5	pKd	=	10.5	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
	25195533	85161	2	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2103803	85161	2	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL2110584	85161	2	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589580	179927	0	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL452142	179927	0	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL553448	179927	0	None	-	0	Human	10.3	pKd	=	10.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	635	10	5	7	5.3	C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1	10.1016/j.bmcl.2008.09.020
	132947	10636	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	361	10636	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	CHEMBL265256	10636	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
	132947	10636	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	361	10636	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	CHEMBL265256	10636	9	None	-	0	Human	9.8	pKd	=	9.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
	25034186	208217	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL540396	208217	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL604842	208217	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	722	11	4	8	7.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589579	195833	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL509515	195833	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	CHEMBL540148	195833	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	595	10	5	7	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)s1	10.1016/j.bmcl.2008.09.020
	11766733	162533	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202003	162533	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL405739	162533	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	132947	10636	9	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	361	10636	9	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	CHEMBL265256	10636	9	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
	10770914	31833	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL134692	31833	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44232952	110160	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084650	110160	0	None	-	0	Human	9.5	pKd	=	9.5	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10580398	28383	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL131748	28383	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	677	24	3	7	6.0	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	316	9611	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	317	9611	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	71183	9611	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL3140030	9611	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	CHEMBL376897	9611	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	DB00462	9611	19	None	-	8	Guinea pig	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 minsAntagonist activity at muscarinic M2 receptor in guinea pig left atrium assessed as effect on electrically-stimulated inotropic activity after 60 mins	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
	316	9611	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	317	9611	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	71183	9611	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL3140030	9611	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	CHEMBL376897	9611	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	DB00462	9611	19	None	-138	8	Human	9.3	pKd	=	9.3	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
	10109130	139793	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL370232	139793	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10291366	147477	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL381623	147477	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	69058946	113252	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084658	113252	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140110	113252	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	10629559	30523	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL133561	30523	0	None	-	0	Human	9.3	pKd	=	9.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	25	4	10	7.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	10628017	28488	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL131865	28488	0	None	-	0	Human	9.2	pKd	=	9.2	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939891	176143	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL442014	176143	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939891	176143	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	CHEMBL442014	176143	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00075a032
	9946298	79602	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200171	79602	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406481	79650	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200319	79650	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44406573	79749	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200693	79749	0	None	-	0	Human	9.1	pKd	=	9.1	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	10532418	31377	0	None	-	0	Human	9.0	pKd	=	9.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL134294	31377	0	None	-	0	Human	9.0	pKd	=	9.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	664	27	3	7	7.4	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	25034182	179363	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL448870	179363	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	CHEMBL540359	179363	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
	25034182	179363	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL448870	179363	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL540359	179363	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16116085	18618	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1182201	18618	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL219786	18618	0	None	-	0	Human	9.0	pKd	=	9	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	12872437	18830	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL1183585	18830	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	CHEMBL306182	18830	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
	11691950	19534	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL1187853	19534	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	CHEMBL524097	19534	0	None	-	0	Human	8.9	pKd	=	8.9	Functional	Antagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assayAntagonist activity at human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic based-FLIPR assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
	174174	7311	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	260	7311	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	320	7311	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	CHEMBL517712	7311	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	DB00572	7311	49	None	-6	7	Human	8.9	pKd	=	8.9	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00121a017
	10771937	28465	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL1202004	28465	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	CHEMBL131846	28465	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
	25034184	195176	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL501803	195176	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	CHEMBL539887	195176	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assayAntagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by single concentration kinetic FLIPR assay	ChEMBL	676	11	4	7	6.1	Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1	10.1021/jm800634k
	44589581	195567	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL505751	195567	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	CHEMBL540145	195567	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	615	12	5	6	4.9	C=CC[N+]1(Cc2cccc(O)c2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC(C)C)cc2)C1	10.1016/j.bmcl.2008.09.020
	14939896	88862	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201996	88862	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216566	88862	0	None	-	0	Human	8.8	pKd	=	8.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406686	147689	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL382213	147689	0	None	-	0	Human	8.7	pKd	=	8.7	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	174174	7311	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	260	7311	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	320	7311	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	CHEMBL517712	7311	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	DB00572	7311	49	None	-6	7	Human	8.7	pKd	=	8.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
	44341782	16765	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL114885	16765	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44318928	212542	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	CHEMBL82859	212542	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
	44319043	212838	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85391	212838	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11753447	194130	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493265	194130	0	None	-	0	Human	7.0	pKd	=	7	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	459	7	2	4	4.4	CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	2166	9897	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	305	9897	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	5910	9897	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL550	9897	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	DB01085	9897	49	None	-131	10	Rat	5.0	pKd	=	5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	128222	108865	6	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL302179	108865	6	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCCNCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44341878	117117	0	None	-	0	Human	6.0	pKd	=	6.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL324026	117117	0	None	-	0	Human	6.0	pKd	=	6.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	674	13	2	8	5.8	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	14939893	16306	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL112244	16306	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	154734599	9281	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	327	9281	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	4108	9281	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL27673	9281	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	154734599	9281	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	327	9281	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	4108	9281	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	CHEMBL27673	9281	12	None	47	5	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
	44319071	212798	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL84993	212798	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11556983	194144	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493331	194144	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL538864	194144	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL555476	194144	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	544	8	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	44341782	16765	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL114885	16765	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	44341782	16765	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL114885	16765	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	611	29	2	6	7.9	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	10789183	111144	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL310132	111144	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44318782	212912	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85996	212912	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44380974	64339	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	CHEMBL166544	64339	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	558	27	4	4	7.5	Fc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(F)cc2)cc1	10.1021/jm00121a017
	101720828	103895	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	16147087	103895	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202002	103895	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL267643	103895	0	None	-	0	Human	7.9	pKd	=	7.9	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	44381057	64886	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL167587	64886	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	651	34	4	5	9.9	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44380592	66084	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	CHEMBL170554	66084	0	None	-	0	Human	6.9	pKd	=	6.9	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(OC)cc2)cc1	10.1021/jm00121a017
	154734599	9281	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	327	9281	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	4108	9281	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL27673	9281	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	154734599	9281	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	327	9281	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	4108	9281	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	CHEMBL27673	9281	12	None	47	5	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
	101676031	104103	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	16175987	104103	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201998	104103	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL269272	104103	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	319	8106	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	321	8106	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	444031	8106	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	784	8106	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	CHEMBL1346	8106	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	DB00496	8106	44	None	-436	18	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
	2705	10614	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	360	10614	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	443879	10614	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	CHEMBL1382	10614	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	DB01036	10614	64	None	-1	9	Human	7.8	pKd	=	7.8	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
	44380973	127509	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	CHEMBL354855	127509	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(OC)c2)c1	10.1021/jm00121a017
	44319342	212497	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL82512	212497	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44319339	212686	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83982	212686	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	44341864	115988	0	None	-	0	Human	5.8	pKd	=	5.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL321687	115988	0	None	-	0	Human	5.8	pKd	=	5.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	575	7	2	7	4.7	CCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44380309	65550	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168736	65550	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	554	27	4	6	6.4	COc1ccccc1CNCCCCCNCCCCCCCCNCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	44298537	107819	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL294613	107819	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	639	29	0	6	8.6	COc1ccccc1CN(C)CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	44380837	65214	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	CHEMBL168304	65214	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)cc2)cc1	10.1021/jm00121a017
	44381064	65035	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168235	65035	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	611	29	2	6	7.9	COc1ccccc1CN(C)CCCCCCNCCCCCCCCNCCCCCCN(C)Cc1ccccc1OC	10.1021/jm00121a017
	10316726	18800	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	18800	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	18800	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16144765	103654	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL265592	103654	0	None	-	0	Human	7.8	pKd	=	7.8	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1403	29	4	16	11.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	44380612	65966	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	CHEMBL170113	65966	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(Cl)cc2)cc1	10.1021/jm00121a017
	44341975	16300	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	CHEMBL112208	16300	0	None	-	0	Human	6.8	pKd	=	6.8	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	543	14	1	6	5.7	CCN(CC)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC	10.1021/jm00046a021
	44380613	65269	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	CHEMBL168322	65269	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1cccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccc(Cl)c2)c1	10.1021/jm00121a017
	154734599	9281	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	327	9281	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	4108	9281	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL27673	9281	12	None	47	5	Human	7.7	pKd	=	7.7	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	10049361	212900	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL85892	212900	0	None	-	0	Human	7.7	pKd	=	7.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	9913892	212616	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL83459	212616	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	14537191	154767	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL39342	154767	0	None	-	0	Human	5.7	pKd	=	5.7	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
	10486393	148480	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202000	148480	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL385625	148480	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10794142	29708	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL132926	29708	0	None	-	0	Human	8.6	pKd	=	8.6	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	635	25	3	7	6.6	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	1734	6904	10	None	-97	6	Human	8.6	pKd	=	8.6	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	307	6904	10	None	-97	6	Human	8.6	pKd	=	8.6	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	CHEMBL168067	6904	10	None	-97	6	Human	8.6	pKd	=	8.6	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
	16086059	87550	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	CHEMBL215180	87550	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atriaAntagonist activity at M2 receptor assessed as inhibition of carbachol-induced bradycardia in rat atria	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
	10722780	29071	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL132377	29071	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	638	27	2	6	7.0	COc1ccccc1CNCCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355098	31475	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134382	31475	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	540	26	4	6	6.1	COc1ccccc1CNCCCCCCNCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	44355099	172030	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL422977	172030	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	568	28	4	6	6.8	COc1ccccc1CNCCCCCCNCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm9810452
	11365314	194131	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	CHEMBL493266	194131	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	473	8	2	4	4.8	CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1	10.1021/jm800935u
	44341764	16726	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL114681	16726	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	423	11	2	5	3.8	CCN(CC)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10402105	117268	0	None	-	0	Human	5.6	pKd	=	5.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	CHEMBL324855	117268	0	None	-	0	Human	5.6	pKd	=	5.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	292	12	1	3	3.7	CCN(CC)CCCCCCNCc1ccccc1OC	10.1021/jm00046a021
	14211056	113940	0	None	-	1	Rat	5.6	pKd	=	5.6	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316309	113940	0	None	-	1	Rat	5.6	pKd	=	5.6	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380611	65598	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	CHEMBL168841	65598	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	614	29	4	6	8.7	CSc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1SC	10.1021/jm00121a017
	44380972	127028	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL352334	127028	0	None	-	0	Human	7.6	pKd	=	7.6	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	611	31	4	6	8.0	COc1ccccc1CNCCCCCCCNCCCCCCCCNCCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	14939888	16934	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	CHEMBL115878	16934	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	370	21	2	4	4.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN	10.1021/jm00046a021
	44381066	65798	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	CHEMBL169290	65798	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1	10.1021/jm00121a017
	14939894	17068	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL116172	17068	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44406598	79800	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200957	79800	0	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	129989	7239	51	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	8584	7239	51	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	CHEMBL43383	7239	51	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor)	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
	71128	103585	25	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	CHEMBL26505	103585	25	None	-	0	Human	8.5	pKd	=	8.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
	66875589	110167	0	None	-	1	Human	8.4	pKd	=	8.4	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084662	110167	0	None	-	1	Human	8.4	pKd	=	8.4	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589576	195835	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL509520	195835	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL555706	195835	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	588	10	6	5	3.9	CC(C)NC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3ccc(O)cc3)C2)cc1	10.1016/j.bmcl.2008.09.020
	44406480	79619	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL200210	79619	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44319009	113713	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	CHEMBL314831	113713	0	None	-	0	Human	7.5	pKd	=	7.5	Functional	Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaAntagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atria	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
	11249888	194156	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL493465	194156	0	None	-	0	Human	6.5	pKd	=	6.5	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	442	6	2	4	4.1	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537192	107000	0	None	-	0	Human	5.5	pKd	=	5.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL288482	107000	0	None	-	0	Human	5.5	pKd	=	5.5	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	189509	112777	13	None	-	1	Rat	5.5	pKd	=	5.5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL313227	112777	13	None	-	1	Rat	5.5	pKd	=	5.5	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44365882	64898	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL167690	64898	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	625	32	4	6	8.4	COc1ccccc1CNCCCCCCNCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	2028	9753	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	359	9753	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	4634	9753	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	CHEMBL1231	9753	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	DB01062	9753	80	None	-7	14	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
	44406520	142036	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL372566	142036	0	None	-	0	Human	7.4	pKd	=	7.4	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	15114860	113933	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL316282	113933	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	210	3	1	4	1.0	CC[C@@H]1C(O)OC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	14211057	118202	0	None	-	1	Rat	5.4	pKd	=	5.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL327363	118202	0	None	-	1	Rat	5.4	pKd	=	5.4	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	226	3	1	4	1.7	CC[C@@H]1C(O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	10316726	18800	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL1183364	18800	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	CHEMBL292857	18800	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Evaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atriaEvaluation of antagonistic affinity against muscarinic receptor (M2) in guinea pig left atria	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
	16115945	19069	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL1184886	19069	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	CHEMBL376057	19069	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atriaAntagonist activity at muscarinic receptor M2 assessed as contraction of electrically-stimulated guinea pig left atria	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
	10606253	164052	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	CHEMBL407678	164052	0	None	-	0	Human	8.4	pKd	=	8.4	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
	14939895	88894	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201997	88894	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL216629	88894	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10055202	18305	1	None	-	0	Human	6.4	pKd	=	6.4	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	CHEMBL11805	18305	1	None	-	0	Human	6.4	pKd	=	6.4	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm9810452
	14939897	103324	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201994	103324	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL262913	103324	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	44233192	113259	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084643	113259	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3140141	113259	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	11504490	199381	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL521523	199381	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	11504490	199381	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	CHEMBL521523	199381	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay	ChEMBL	514	8	3	4	4.8	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1	10.1016/j.bmcl.2009.01.098
	44589582	178420	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL446587	178420	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL550885	178420	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	577	12	4	5	4.6	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](CC3CC3)(CC3CC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	16042745	192080	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL485932	192080	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	CHEMBL538360	192080	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	551	8	4	5	4.4	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+]3(CCCCCC3)C2)cc1	10.1016/j.bmcl.2008.09.020
	10557581	28546	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL1202001	28546	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	CHEMBL131913	28546	0	None	-	0	Human	8.3	pKd	=	8.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
	10418181	16358	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112500	16358	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL1201995	16358	1	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	9843814	134027	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	CHEMBL36583	134027	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
	14449843	31594	0	None	-	0	Human	6.3	pKd	=	6.3	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	CHEMBL134488	31594	0	None	-	0	Human	6.3	pKd	=	6.3	Functional	Antagonistic potency against Muscarinic acetylcholine receptor M2Antagonistic potency against Muscarinic acetylcholine receptor M2	ChEMBL	610	27	4	6	6.3	COc1ccccc1CNCCCCCC(=O)NCCCCCCCCNC(=O)CCCCCNCc1ccccc1OC	10.1021/jm9810452
	14211049	113765	0	None	-	1	Rat	5.3	pKd	=	5.3	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL315191	113765	0	None	-	1	Rat	5.3	pKd	=	5.3	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	224	3	0	4	1.9	CC[C@H]1C(=O)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	2200	9905	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	328	9905	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	4848	9905	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	CHEMBL9967	9905	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	DB00670	9905	46	None	-114	10	Human	4.3	pKd	=	4.3	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
	44381142	65837	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	CHEMBL169523	65837	0	None	-	0	Human	7.3	pKd	=	7.3	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	524	27	4	6	6.0	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccn2)nc1	10.1021/jm00121a017
	10653319	31015	0	None	-	0	Human	5.3	pKd	=	5.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL133993	31015	0	None	-	0	Human	5.3	pKd	=	5.3	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	901	24	3	10	7.3	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44380591	65525	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	CHEMBL168616	65525	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	550	27	4	4	7.8	Cc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1C	10.1021/jm00121a017
	44406521	80681	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	CHEMBL201933	80681	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladderAntagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
	44233190	110179	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	CHEMBL3084679	110179	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assayAntagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by measuring ratio of acetylcholine EC50 in presence and absence of compound by FLIPR assay	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
	44589578	179949	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL452193	179949	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	CHEMBL540401	179949	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1nc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)no1	10.1016/j.bmcl.2008.09.020
	44589577	195747	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL508343	195747	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	CHEMBL540146	195747	0	None	-	0	Human	8.2	pKd	=	8.2	Functional	Antagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assayAntagonist activity at human recombinant muscarinic M2 receptor expressed in CHO cells coexpressing chimeric G protein Gqi5 assessed as inhibition of acetylcholine-induced intracellular Ca2+ mobilization by FLIPR assay	ChEMBL	585	9	5	7	4.1	Cc1noc(-c2ccc(NC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H]3CCC[N+](C)(Cc4ccc(O)cc4)C3)cc2)n1	10.1016/j.bmcl.2008.09.020
	25132856	193995	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	CHEMBL492437	193995	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assayAntagonist activity at cloned muscarinic M2 receptor-Gqi5 chimeric protein expressed in CHO cells assessed as acetylcholine-induced change in cytosolic calcium concentration by FLIPR assay	ChEMBL	515	8	3	5	3.6	C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1	10.1021/jm800935u
	14537188	143324	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	CHEMBL37372	143324	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
	14211052	213315	0	None	-	1	Rat	6.2	pKd	=	6.2	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	CHEMBL88578	213315	0	None	-	1	Rat	6.2	pKd	=	6.2	Functional	Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)	ChEMBL	240	3	0	4	2.7	CC[C@H]1C(=S)SC[C@@H]1Cc1cncn1C	10.1021/jm00079a002
	44380614	64241	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	CHEMBL165700	64241	0	None	-	0	Human	7.2	pKd	=	7.2	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	590	27	4	4	8.5	Clc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1Cl	10.1021/jm00121a017
	59993948	79917	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	CHEMBL2011501	79917	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Orthosteric antagonist activity at M2 receptor by AS-MS analysisOrthosteric antagonist activity at M2 receptor by AS-MS analysis	ChEMBL	556	8	1	6	5.3	O=C(N[C@H]1CCCC[C@@H]1OCc1ccccc1)c1coc(-c2ccc(C(=O)N3CCC(N4CCCC4)CC3)cc2)n1	10.1016/j.bmc.2011.11.071
	14537189	169422	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	CHEMBL416974	169422	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
	14939893	16306	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	CHEMBL112244	16306	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
	10369736	66138	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	CHEMBL170793	66138	0	None	-	0	Human	8.1	pKd	=	8.1	Functional	Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaAntagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atria	ChEMBL	530	27	4	6	7.0	Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1	10.1021/jm00121a017
	44381205	64301	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	CHEMBL166232	64301	0	None	-	0	Human	7.1	pKd	=	7.1	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	522	27	4	4	7.2	c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccccc2)cc1	10.1021/jm00121a017
	10508599	122007	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL334690	122007	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	663	23	3	7	5.6	CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	44381378	64300	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	CHEMBL166229	64300	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	502	27	4	6	6.4	c1coc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccco2)c1	10.1021/jm00121a017
	129989	7239	51	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	8584	7239	51	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	CHEMBL43383	7239	51	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
	10651844	122267	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	CHEMBL335115	122267	0	None	-	0	Human	8.0	pKd	=	8.0	Functional	Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atriumAntagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
	14914761	16736	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	CHEMBL114738	16736	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist]	ChEMBL	462	25	4	5	5.4	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCN	10.1021/jm00046a021
	44380975	64381	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	CHEMBL166803	64381	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	612	29	4	8	7.0	O=[N+]([O-])c1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm00121a017
	44365718	65560	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	CHEMBL168786	65560	0	None	-	0	Human	7.0	pKd	=	7.0	Functional	Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorAntagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor	ChEMBL	653	34	4	6	9.2	COc1ccccc1CNCCCCCCNCCCCCCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00121a017
	9916852	211698	0	None	-	0	Human	11.0	pKi	=	11	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL76164	211698	0	None	-	0	Human	11.0	pKi	=	11	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	44314347	109640	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL305693	109640	0	None	-	0	Human	9.9	pKi	=	9.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	640	7	0	7	5.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10230930	87409	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	CHEMBL2151158	87409	0	None	-	0	Human	9.8	pKi	=	9.8	Functional	Antagonist activity at human muscarinic M2 receptorAntagonist activity at human muscarinic M2 receptor	ChEMBL	548	13	1	5	5.7	CCN(CC)CCOc1ccc(CN2CCC(C3CCN(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)cc1	10.1021/jm100064d
	44314697	110957	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL309720	110957	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314564	211587	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL75108	211587	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)cc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	195246	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	195246	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	195246	0	None	-	0	Human	9.6	pKi	=	9.6	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314328	110488	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308787	110488	0	None	-	0	Human	9.5	pKi	=	9.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	676	7	0	7	6.2	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(F)ccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10417432	111651	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311099	111651	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	718	7	0	7	6.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7c(Br)cccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	10009554	211490	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL74141	211490	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314698	211931	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL78131	211931	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(F)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164610746	195246	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4854886	195246	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028038	195246	0	None	-	0	Human	9.1	pKi	=	9.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 58 nM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314329	211335	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL72932	211335	0	None	-	0	Human	9.0	pKi	=	9	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cccc(F)c67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314699	109956	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL308166	109956	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7ccc(F)cc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	44314713	111647	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	CHEMBL311054	111647	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity against muscarinic acetylcholine receptor M2Antagonistic activity against muscarinic acetylcholine receptor M2	ChEMBL	674	7	0	7	6.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc7cc(Cl)ccc67)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(01)00435-8
	164615651	195290	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	195290	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	195290	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring right ward shift of iperoxo-concentration-response curves at 16 uM preincubated for 120 mins followed by iperoxo-addition and measured by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	164614830	195279	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4858774	195279	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028275	195279	0	None	-	0	Human	6.9	pKi	=	6.9	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	44314554	112460	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	CHEMBL312571	112460	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	592	9	0	8	3.6	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(01)00435-8
	3009356	112400	1	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL312344	112400	1	None	-	0	Human	5.5	pKi	=	5.5	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	543	6	0	5	5.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](CC3CC3)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	483747	112186	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	CHEMBL311795	112186	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0304515
	3009352	103414	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL263555	103414	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	517	5	0	5	5.3	CC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	3009353	174804	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	CHEMBL432170	174804	1	None	-	0	Human	5.3	pKi	=	5.3	Functional	Antagonistic activity against Muscarinic acetylcholine receptor M2Antagonistic activity against Muscarinic acetylcholine receptor M2	ChEMBL	531	6	0	5	5.7	CCC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(C2(C)CCN(C(=O)c3c(C)ncnc3C)CC2)C[C@@H]1C	10.1021/jm0304515
	1935	10506	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	2551	10506	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	6687	10506	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	CHEMBL95	10506	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	DB00382	10506	97	None	-57	12	Human	5.2	pKi	=	5.2	Functional	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
	164615651	195290	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL4852079	195290	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	CHEMBL5028329	195290	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase techniqueAntagonist activity at human muscarinic acetylcholine receptor M2 expressed in human HEK293T cells coexpressing NlucN-mini-Gsi assessed as inhibition of iperoxo-induced mini-Gsi recruitment by measuring equilibrium binding constant by nano-luciferase technique	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
	313	9468	0	None	-	1	Human	6.3	pA2	<	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9862767
	2520	210787	70	None	-3	20	Pig	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL1280	210787	70	None	-3	20	Pig	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL6966	210787	70	None	-3	20	Pig	8.4	pEC50	=	8.4	Functional	NoneNone	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	1935	10506	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	2551	10506	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	6687	10506	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	CHEMBL95	10506	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	DB00382	10506	97	None	-1	12	Pig	8.3	pEC50	=	8.3	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
	1979	84101	70	None	-43	7	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	CHEMBL20835	84101	70	None	-43	7	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
	123603	7670	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2684	7670	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	584	7670	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	9658	7670	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	CHEMBL168815	7670	29	None	-22	5	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	None
	2370	7410	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	297	7410	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	358	7410	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	CHEMBL1482	7410	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	DB01019	7410	31	None	19	3	Guinea pig	8.2	pEC50	=	8.2	Functional	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
	1273	8535	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	3450	8535	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	356	8535	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	6172	8535	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	67425	8535	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	CHEMBL360055	8535	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	DB00483	8535	16	None	38	4	Pig	8.2	pEC50	=	8.2	Functional	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
	2166	9897	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	305	9897	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5910	9897	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	CHEMBL550	9897	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	DB01085	9897	49	None	-28	10	Human	8.2	pEC50	=	8.2	Functional	calcium response in CHO cellscalcium response in CHO cells	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
	5831	222742	0	None	-1	5	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
	21158560	119570	7	None	3090	2	Pig	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	CHEMBL3305985	119570	7	None	3090	2	Pig	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
	10101670	8291	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	7635	8291	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	CHEMBL32985	8291	0	None	52	2	Human	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	16157694
	10104167	8840	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	10104167	8840	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	6937	8840	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	6937	8840	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	CHEMBL3121473	8840	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	23062057
	CHEMBL3121473	8840	2	None	-1	3	Human	9.8	pEC50	=	9.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	24863257
	288	7040	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	288	7040	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	6979053	7040	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	17392404
	6979053	7040	0	None	3	5	Human	5.7	pEC50	None	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@H]1C[NH+]2CCC1CC2	8968358
	286	7039	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	286	7039	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	6954180	7039	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	17392404
	6954180	7039	0	None	3	5	Human	6.3	pEC50	None	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	170	1	1	2	-0.8	CC(=O)O[C@@H]1C[NH+]2CCC1CC2	8968358
	18381	224486	0	None	-1	4	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	469	4	2	6	3.2	CC1=C(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(O)=O)C(=NO1)C1=C(Cl)C=CC=C1Cl	None
	11434515	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11434515	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	11519741	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	11519741	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	4484	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	4484	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	7449	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	7449	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	CHEMBL1194325	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	CHEMBL1194325	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	DB08897	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	19653626
	DB08897	7049	6	None	1	11	Human	10.1	pIC50	=	10.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	21036042
	1935	10506	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	2551	10506	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	6687	10506	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	CHEMBL95	10506	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	DB00382	10506	97	None	-19	12	Mouse	5.7	pIC50	=	5.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	1552502
	154059	10409	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	2457	10409	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	7483	10409	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	CHEMBL1734	10409	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	DB01591	10409	51	None	-4	3	Human	6.2	pIC50	=	6.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	21524581
	11693	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	11693	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	3494	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	3494	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	4302	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	4302	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	7459	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	7459	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	CHEMBL1201335	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	CHEMBL1201335	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200
	DB00986	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	21036043
	DB00986	8608	16	None	-3	7	Human	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	22854200

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		3000322	10335	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		330	10335	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		CHEMBL569713	10335	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		DB00747	10335	38	None	-5	6	Human	9.2	pAC50	=	9.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		11434515	7049	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		11519741	7049	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		4484	7049	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		7449	7049	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL1194325	7049	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		DB08897	7049	6	None	-6	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
		367	10596	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		5487427	10596	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		8592	10596	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL1900528	10596	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL3305968	10596	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL4650755	10596	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		DB01409	10596	12	None	-2	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		11693	8608	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		3494	8608	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4302	8608	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		7459	8608	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201335	8608	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB00986	8608	16	None	-2	5	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		25897919	62426	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		657309	62426	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1464005	62426	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1621597	62426	14	None	-1	8	Human	9.1	pAC50	=	9.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		25897919	62426	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		657309	62426	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1464005	62426	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1621597	62426	14	None	-1	8	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		11693	8608	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		3494	8608	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4302	8608	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		7459	8608	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201335	8608	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB00986	8608	16	None	-2	5	Human	8.9	pAC50	=	8.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		2705	10614	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		360	10614	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		443879	10614	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		CHEMBL1382	10614	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		DB01036	10614	64	None	-1	10	Human	8.0	pAC50	=	8.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		3157	8252	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	8252	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	8252	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	8252	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	8252	71	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		242	7258	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	7258	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	7258	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	7258	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	7258	124	None	-295	51	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		133	9274	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		1723	9274	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		28693	9274	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		CHEMBL19215	9274	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		DB13520	9274	52	None	-	43	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		CHEMBL1630575	63117	0	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
		441383	27105	57	None	-7	17	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1306	27105	57	None	-7	17	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		2335	18620	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	18620	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	18620	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	18620	22	None	-2	12	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		4919	213013	23	None	-3	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL86715	213013	23	None	-3	9	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		3652	10869	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		57	10869	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		60809	10869	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		CHEMBL21536	10869	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		DB15357	10869	79	None	-18	18	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		3152	195190	103	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		CHEMBL502	195190	103	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		2200	9905	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		328	9905	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		4848	9905	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		CHEMBL9967	9905	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		DB00670	9905	46	None	-35	13	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		1613	9127	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	9127	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	9127	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	9127	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	9127	53	None	-42	44	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		43815	193699	64	None	-15	25	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		CHEMBL1708	193699	64	None	-15	25	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		CHEMBL490	193699	64	None	-15	25	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
		1209	8439	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		203	8439	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		3386	8439	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL41	8439	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00472	8439	75	None	-22	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		5994	11413	88	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
		CHEMBL103	11413	88	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
		2200	9905	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		328	9905	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		4848	9905	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		CHEMBL9967	9905	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		DB00670	9905	46	None	-35	13	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1038/s41467-023-40064-9
		5050	84975	58	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL2105300	84975	58	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	355	4	1	5	3.5	Cc1ccc2c([nH]c(=O)c3c(=O)cc(C(=O)OCCC(C)C)oc32)c1C	10.1038/s41467-023-40064-9
		31315	100183	63	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL245807	100183	63	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	2	3	3	3.4	O=C1Nc2ccccc2C1(c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		5353853	24758	47	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9556529	24758	47	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1262	24758	47	None	-	15	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL3039583	217728	0	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
		3775	21247	26	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201232	21247	26	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	353	8	1	1	4.1	CC(C)[N+](C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
		4097	21254	13	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1201264	21254	13	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	0	3	4.0	CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		2774	10640	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		5593	10640	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		7319	10640	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		CHEMBL1200604	10640	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		DB00809	10640	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		DB01199	10640	95	None	-1	10	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		2402	10143	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		5095	10143	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		7295	10143	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		CHEMBL589	10143	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		DB00268	10143	62	None	-	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
		15387	52596	55	None	-16	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1531134	52596	55	None	-16	24	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		1273	8535	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		3450	8535	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		356	8535	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		6172	8535	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		67425	8535	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		CHEMBL360055	8535	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		DB00483	8535	16	None	-1	3	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		4904	162300	48	None	-1	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL404215	162300	48	None	-1	5	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4209	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		176870	202264	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
		CHEMBL553	202264	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	10	1	7	3.4	C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1	10.1038/s41467-023-40064-9
		4209	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	9937	75	None	-	33	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		3678	101567	57	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL253371	101567	57	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		460612	212823	66	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		6918992	212823	66	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL852	212823	66	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	8	2	3	1.9	N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O	10.1038/s41467-023-40064-9
		5282592	21248	2	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1201235	21248	2	None	-	0	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	3	1	3	2.0	C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2	10.1038/s41467-023-40064-9
		16222096	87258	67	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
		CHEMBL2146883	87258	67	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
		6918456	21287	110	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
		CHEMBL1201772	21287	110	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	373	5	0	5	3.9	CC(=O)Oc1cc2c(s1)CCN(C(C(=O)C1CC1)c1ccccc1F)C2	10.1038/s41467-023-40064-9
		103	10925	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	10925	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	10925	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	10925	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	10925	61	None	-177	53	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2444	21250	26	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201245	21250	26	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		1201549	7384	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		333	7384	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7601	7384	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201203	7384	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL438151	7384	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00245	7384	24	None	-5	20	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		24958200	15346	76	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
		CHEMBL1094636	15346	76	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	320	3	2	4	2.6	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	10.1038/s41467-023-40064-9
		5523	10623	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
		8286	10623	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1237044	10623	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
		DB00193	10623	25	None	-	4	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	3	2.6	COc1cccc(c1)C1(O)CCCCC1CN(C)C	10.1038/s41467-023-40064-9
		5426	185464	117	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
		CHEMBL468	185464	117	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	258	1	1	4	0.1	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1	10.1038/s41467-023-40064-9
		135398745	9688	112	None	-38	65	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	9688	112	None	-38	65	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	9688	112	None	-38	65	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	9688	112	None	-38	65	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		3627	50903	18	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1515447	50903	18	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		3447	213155	28	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
		CHEMBL87563	213155	28	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	321	9	3	5	1.8	CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1	10.1038/s41467-023-40064-9
		2247	7293	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	7293	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	7293	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	7293	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	7293	81	None	-32	42	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		20299	21277	15	None	-	0	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL1201354	21277	15	None	-	0	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	8	1	1	4.7	CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		1712	9270	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		4078	9270	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		7227	9270	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		CHEMBL1088	9270	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		DB00933	9270	43	None	-5	22	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		4594	49646	127	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
		CHEMBL1503	49646	127	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1038/s41467-023-40064-9
		5584	209990	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL644	209990	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		4735	201894	96	None	-9	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL361506	201894	96	None	-9	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL55	201894	96	None	-9	10	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		2166	9897	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		305	9897	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		5910	9897	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		CHEMBL550	9897	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		DB01085	9897	49	None	-34	8	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1038/s41467-023-40064-9
		2745	10633	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		5572	10633	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		66007	10633	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		7315	10633	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL1490	10633	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		DB00376	10633	42	None	-46	9	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1038/s41467-023-40064-9
		154417	29953	60	None	-1	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1331216	29953	60	None	-1	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		5311064	8148	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
		534	8148	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
		806	8148	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
		CHEMBL493682	8148	46	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	3	5	2.3	COc1cc(CCNC[C@@H](c2ccc(cc2)O)O)ccc1OC	10.1038/s41467-023-40064-9
		2286	9957	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	9957	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	9957	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	9957	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	9957	51	None	-3	30	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		2247	7293	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	7293	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	7293	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	7293	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	7293	81	None	-32	42	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2480	26212	49	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
		CHEMBL129529	26212	49	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	306	11	1	4	3.7	CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
		49803313	119363	69	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
		CHEMBL3301622	119363	69	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	552	9	3	10	2.7	CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1	10.1038/s41467-023-40064-9
		3344	205097	57	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		CHEMBL576127	205097	57	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		54758501	145845	58	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		CHEMBL3786343	145845	58	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		6127	21271	8	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1201340	21271	8	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		72287	67835	38	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1764	67835	38	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL4743867	220812	14	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
		71109	84981	10	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
		CHEMBL2105453	84981	10	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
		24821094	73868	93	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1873475	73868	93	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
		62867	9903	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		7557	9903	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL398880	9903	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01621	9903	35	None	-	2	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		3103	48432	49	None	-	4	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1492	48432	49	None	-	4	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		9571107	174298	33	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		CHEMBL430	174298	33	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		2337	10030	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	10030	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	10030	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	10030	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	10030	77	None	-31	62	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5591	164310	90	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		CHEMBL408	164310	90	None	-	2	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		1224	8214	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	8214	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	8214	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	8214	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	8214	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	8214	83	None	-6	13	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		40973	52809	70	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
		CHEMBL1533	52809	70	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
		3606	210267	60	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL6615	210267	60	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		180	7189	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	7189	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	7189	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	7189	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	7189	56	None	-27	40	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		1599	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3955	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7215	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL841	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00836	9120	50	None	-	16	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		135400189	51349	73	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
		CHEMBL1520	51349	73	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
		135398737	7745	93	None	-22	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	7745	93	None	-22	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	7745	93	None	-22	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	7745	93	None	-22	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	7745	93	None	-22	90	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		4417	62336	54	None	-	1	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL1439099	62336	54	None	-	1	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL1620794	62336	54	None	-	1	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL5292015	201316	0	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	6	1	3	3.6	C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1038/s41467-023-40064-9
		6077	157477	31	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL39560	157477	31	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		40466968	213815	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
		60947	213815	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL916	213815	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	14	3	5	3.0	CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O	10.1038/s41467-023-40064-9
		CHEMBL5291995	201315	0	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		41049	113537	40	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
		CHEMBL314437	113537	40	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	233	2	1	2	3.2	CCC1(c2cccc(O)c2)CCCCN(C)C1	10.1038/s41467-023-40064-9
		18609376	211138	63	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		6279	211138	63	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL717	211138	63	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	386	2	0	4	4.7	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		3294	8787	111	None	-194	44	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	8787	111	None	-194	44	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	8787	111	None	-194	44	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	8787	111	None	-194	44	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	8787	111	None	-194	44	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		1726	9275	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		1993	9275	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		7438	9275	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		CHEMBL978	9275	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		DB06709	9275	13	None	-2	5	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		5440	35497	37	None	-	9	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1378	35497	37	None	-	9	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		193962	110570	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		CHEMBL308954	110570	106	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		9853053	127297	74	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		CHEMBL354541	127297	74	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		24821094	73868	93	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1873475	73868	93	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
		2895	210371	41	None	-1	8	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL669	210371	41	None	-1	8	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		121515	205878	63	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL588934	205878	63	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	4	1	4	3.4	CC[C@H]1CN2CC[C@H]1C[C@H]2[C@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		443869	84916	45	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2103761	84916	45	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		432824	85039	13	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
		CHEMBL2106996	85039	13	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
		10180	105645	47	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL279014	105645	47	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		208898	72973	78	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		CHEMBL184412	72973	78	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		4761	20213	42	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1193	20213	42	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1580221	20213	42	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	240	5	0	2	3.2	CN(C)CCC(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		1547484	7727	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		654	7727	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		9072	7727	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL43064	7727	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00568	7727	74	None	-	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		151537	169443	49	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		41867	169443	49	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		CHEMBL417	169443	49	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
		9324	16010	60	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL110691	16010	60	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		5039	69957	17	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
		CHEMBL1790041	69957	17	None	-	1	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
		5284632	74176	13	None	-1	5	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1888176	74176	13	None	-1	5	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL3084748	74176	13	None	-1	5	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4642	48760	28	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL1495	48760	28	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	344	5	1	5	2.7	CN1CCCN=C1COC(=O)C(O)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		4034	62596	55	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	62596	55	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		7099	202301	59	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		CHEMBL55400	202301	59	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		9419	42696	35	None	-	6	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1442422	42696	35	None	-	6	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		4940	21242	35	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1201210	21242	35	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		4021	107256	122	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
		CHEMBL290916	107256	122	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	174	1	0	2	1.8	CC1=NN(c2ccccc2)C(=O)C1	10.1038/s41467-023-40064-9
		9429	208912	58	None	-	4	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL609109	208912	58	None	-	4	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		3152	195190	103	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		CHEMBL502	195190	103	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
		22530	62904	58	None	-	3	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1600878	62904	58	None	-	3	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1625607	62904	58	None	-	3	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		5351322	101566	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL25336	101566	38	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		708857	62958	44	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
		CHEMBL1626223	62958	44	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	206	2	0	3	2.5	CN1CCCN=C1/C=C/c1cccs1	10.1038/s41467-023-40064-9
		9400	21263	38	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
		CHEMBL1201302	21263	38	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	472	4	4	6	2.0	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O	10.1038/s41467-023-40064-9
		2726	7706	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	7706	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	7706	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	7706	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	7706	68	None	-79	72	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		3180	21245	41	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201217	21245	41	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	8	0	3	3.9	CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		1712095	202171	30	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
		CHEMBL551978	202171	30	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	397	9	1	5	4.9	CCOc1ccc(/C=C2\NCCc3cc(OCC)c(OCC)cc32)cc1OCC	10.1038/s41467-023-40064-9
		25295	20392	37	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1194287	20392	37	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		31101	7516	40	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	7516	40	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	7516	40	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	7516	40	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	7516	40	None	-	35	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		22323	22071	32	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9571037	22071	32	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1213553	22071	32	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		4098	39279	30	None	-15	11	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1255739	39279	30	None	-15	11	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1411979	39279	30	None	-15	11	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		316	9611	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		317	9611	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		71183	9611	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL3140030	9611	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		CHEMBL376897	9611	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		DB00462	9611	19	None	-6	9	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1038/s41467-023-40064-9
		2039	9756	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		5749	9756	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		7257	9756	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		CHEMBL1201286	9756	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		DB00219	9756	19	None	-	1	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	348	8	1	3	3.5	CC[N+](CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)(CC)C	10.1038/s41467-023-40064-9
		2293	9960	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		329	9960	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		4934	9960	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		CHEMBL1180725	9960	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		DB00782	9960	27	None	-2	4	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	10.1038/s41467-023-40064-9
		25897919	62426	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		657309	62426	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1464005	62426	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		CHEMBL1621597	62426	14	None	-1	8	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
		6917866	174216	5	None	-	0	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
		CHEMBL4297364	174216	5	None	-	0	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	332	5	1	4	1.5	CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
		2784	7739	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		351	7739	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		366	7739	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		676	7739	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL620	7739	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		DB00771	7739	13	None	1	3	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	10.1038/s41467-023-40064-9
		174174	7311	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		260	7311	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		320	7311	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		CHEMBL517712	7311	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		DB00572	7311	49	None	-7	14	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		2286	9957	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	9957	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	9957	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	9957	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	9957	51	None	-3	30	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		68778	121983	68	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL334491	121983	68	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	2	0	1	4.9	CC(C)(C)N1CCC(c2ccccc2)(c2ccccc2)CC1	10.1038/s41467-023-40064-9
		1548955	95356	20	None	-1	18	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		2800	95356	20	None	-1	18	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2355051	95356	20	None	-1	18	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		100	10577	58	None	-19	54	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		2637	10577	58	None	-19	54	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		5452	10577	58	None	-19	54	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL479	10577	58	None	-19	54	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB00679	10577	58	None	-19	54	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		242	7258	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	7258	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	7258	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	7258	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	7258	124	None	-295	51	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		3607	43156	72	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
		CHEMBL144673	43156	72	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	339	12	1	3	4.7	CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1	10.1038/s41467-023-40064-9
		93154	12208	29	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL107360	12208	29	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		2898	39425	73	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	364	4	0	4	5.3	CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL141305	39425	73	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	364	4	0	4	5.3	CC(=O)Oc1ccc(C(=C2CCCCC2)c2ccc(OC(C)=O)cc2)cc1	10.1038/s41467-023-40064-9
		2805	168669	38	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL415087	168669	38	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		12555	24733	53	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL12610	24733	53	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		6726	8063	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7151	8063	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		749	8063	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL648	8063	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB01176	8063	51	None	-9	13	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		2749	7132	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		5574	7132	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7237	7132	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL829	7132	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01246	7132	40	None	-	2	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		132999	185880	47	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	468	10	0	6	3.3	COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2	10.1038/s41467-023-40064-9
		CHEMBL471737	185880	47	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	468	10	0	6	3.3	COc1cc2c(cc1OC)CC(=O)N(CCCN(C)C[C@H]1Cc3cc(OC)c(OC)cc31)CC2	10.1038/s41467-023-40064-9
		3354	48558	50	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
		CHEMBL1493	48558	50	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
		3166	176199	23	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL442444	176199	23	None	-	0	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		5354	162435	21	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		CHEMBL404849	162435	21	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		6075	156887	42	None	-7	16	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL395110	156887	42	None	-7	16	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		191	7191	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		201	7191	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2170	7191	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		CHEMBL1113	7191	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		DB00543	7191	98	None	-56	29	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		213046	9164	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	9164	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	9164	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	9164	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	9164	59	None	-	9	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		115163	64077	44	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	439	5	0	7	2.4	CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
		CHEMBL1650818	64077	44	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	439	5	0	7	2.4	CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2C(=O)[C@@H](/N=C/N3CCCCCC3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
		5583	19816	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL119	19816	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
		4601	213526	35	None	-2	17	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201023	213526	35	None	-2	17	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL900	213526	35	None	-2	17	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		160883	62038	9	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
		CHEMBL1618102	62038	9	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12	10.1038/s41467-023-40064-9
		16960	21259	23	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1201287	21259	23	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		5511	12260	40	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	4	0	2	3.3	Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1076211	12260	40	None	-	1	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	245	4	0	2	3.3	Cc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		2333	149113	97	None	-	2	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
		CHEMBL388590	149113	97	None	-	2	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
		124087	8171	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	8171	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	8171	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	8171	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	8171	114	None	-6	15	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		16362	9899	71	None	-	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	9899	71	None	-	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	9899	71	None	-	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	9899	71	None	-	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	9899	71	None	-	29	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		3055	8215	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		313	8215	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		7163	8215	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL936	8215	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		DB01231	8215	44	None	-2	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		135	9310	43	None	-25	56	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	9310	43	None	-25	56	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	9310	43	None	-25	56	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	9310	43	None	-25	56	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	9310	43	None	-25	56	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		60663	182448	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1421212	182448	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1534525	182448	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL45816	182448	42	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		3000322	10335	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		330	10335	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		CHEMBL569713	10335	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		DB00747	10335	38	None	-5	6	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		3053	211913	95	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		CHEMBL780	211913	95	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		43082	67057	37	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1742452	67057	37	None	-	0	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		11519069	10711	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		11519070	10711	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4816	10711	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7354	10711	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1187833	10711	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB09076	10711	3	None	-1	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		11693	8608	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		3494	8608	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4302	8608	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		7459	8608	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201335	8608	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB00986	8608	16	None	-2	5	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		10470	9266	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		1689	9266	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		4057	9266	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		CHEMBL524004	9266	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		DB04843	9266	7	None	-4	3	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1038/s41467-023-40064-9
		180	7189	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	7189	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	7189	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	7189	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	7189	56	None	-27	40	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		4886	20882	28	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1198	20882	28	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
		4919	213013	23	None	-3	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL86715	213013	23	None	-3	9	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		6918558	21286	41	None	-1	5	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201764	21286	41	None	-1	5	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		2771	201796	74	None	-	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	201796	74	None	-	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	201796	74	None	-	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		40	8329	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		77993	8329	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		995	8329	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1510	8329	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		DB00216	8329	58	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		1909	9598	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		2559	9598	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		4474	9598	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL1484	9598	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL3302409	9598	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		DB00622	9598	64	None	-	4	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		54697325	65753	35	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
		CHEMBL1689772	65753	35	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
		7019	174755	106	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL1308088	174755	106	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL43184	174755	106	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		3474	44875	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
		CHEMBL146095	44875	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
		104903	63118	17	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1630578	63118	17	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		1530	8963	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		3827	8963	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		7206	8963	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		CHEMBL534	8963	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		DB00920	8963	50	None	-43	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
		5330286	74345	104	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
		CHEMBL189963	74345	104	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	447	5	2	9	3.0	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O	10.1038/s41467-023-40064-9
		2580	85170	18	None	-	2	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL2110775	85170	18	None	-	2	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		3634	90883	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL22077	90883	51	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		2398	7741	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2801	7741	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		701	7741	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL415	7741	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB01242	7741	62	None	-3	29	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		1427	8794	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		357	8794	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		3696	8794	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL11	8794	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00458	8794	54	None	1	27	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		4908	195585	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
		CHEMBL506	195585	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	6	2	4	2.8	COc1cc(NC(C)CCCN)c2ncccc2c1	10.1038/s41467-023-40064-9
		1086	8371	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		3290	8371	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		7181	8371	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		CHEMBL1206	8371	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		DB00392	8371	27	None	-	2	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		187	7043	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		294	7043	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		65	7043	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		8593	7043	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL667	7043	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		DB03128	7043	39	None	6	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		10071196	9898	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		5142	9898	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		8423	9898	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		CHEMBL2111101	9898	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		DB05316	9898	79	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		187	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		294	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		65	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		8593	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL667	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		DB03128	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		319	8106	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		321	8106	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		444031	8106	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		784	8106	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		CHEMBL1346	8106	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		DB00496	8106	44	None	-20	9	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
		2762	10635	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		5587	10635	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		7318	10635	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL1241	10635	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		DB00792	10635	31	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		11057	182928	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		3468	182928	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL459265	182928	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL64894	182928	23	None	-1	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		187	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		294	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		65	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		8593	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL667	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		DB03128	7043	39	None	6	9	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		2993	121470	24	None	-	0	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL121663	121470	24	None	-	0	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL333826	121470	24	None	-	0	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		70695647	84988	0	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	2	1	1	5.3	C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL2105618	84988	0	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	2	1	1	5.3	C=CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCCC4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		11154555	7587	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		5037	7587	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		7671	7587	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL2028019	7587	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL3085826	7587	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB06016	7587	62	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		5328940	106992	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	106992	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		25151352	147384	67	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		CHEMBL3813873	147384	67	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		4167	21272	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1201342	21272	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		4167	21272	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1201342	21272	43	None	-	0	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		174174	7311	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		260	7311	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		320	7311	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		CHEMBL517712	7311	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		DB00572	7311	49	None	-7	14	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/s41467-023-40064-9
		277	8083	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2913	8083	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		765	8083	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL516	8083	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB00434	8083	62	None	-12	50	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2710	91083	31	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL22150	91083	31	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		4921596	105558	90	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
		60063	105558	90	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
		CHEMBL278255	105558	90	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	3	2	5	2.4	NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1	10.1038/s41467-023-40064-9
		3601	21275	9	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1201349	21275	9	None	-	0	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		16351	109507	47	None	-	6	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL304902	109507	47	None	-	6	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		1210	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		1213	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		2725	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		33036	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		4411	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		616	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		6976	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		716121	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1201353	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL1554789	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		CHEMBL505	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB01114	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		DB13679	7705	51	None	-257	21	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
		5039	69957	17	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
		CHEMBL1790041	69957	17	None	-	1	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
		2337	10030	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	10030	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	10030	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	10030	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	10030	77	None	-31	62	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		3158	63041	27	None	-630	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	63041	27	None	-630	20	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		135565596	116046	70	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	2	11	0.7	COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21	10.1038/s41467-023-40064-9
		CHEMBL3218576	116046	70	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	480	7	2	11	0.7	COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21	10.1038/s41467-023-40064-9
		2107	9829	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		4747	9829	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		9216	9829	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL251940	9829	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB01608	9829	50	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		3158	63041	27	None	-630	20	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	63041	27	None	-630	20	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		2220	9908	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		27400	9908	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		93	9908	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL294951	9908	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB06153	9908	82	None	-	14	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		5568	204279	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		66069	204279	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL1201102	204279	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL570	204279	29	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		11976	7707	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		667467	7707	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		CHEMBL908	7707	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		DB01239	7707	59	None	-23	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		3162	11007	43	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	6	0	3	2.9	CN(C)CCOC(C)(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1004	11007	43	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	270	6	0	3	2.9	CN(C)CCOC(C)(c1ccccc1)c1ccccn1	10.1038/s41467-023-40064-9
		5328940	106992	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	106992	107	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		21722	24764	31	None	-	6	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		CHEMBL126224	24764	31	None	-	6	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
		3336	101776	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1405922	101776	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL254832	101776	30	None	-	1	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		1273	8535	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		3450	8535	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		356	8535	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		6172	8535	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		67425	8535	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		CHEMBL360055	8535	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		DB00483	8535	16	None	-1	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1038/s41467-023-40064-9
		2905	21270	50	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1201338	21270	50	None	-	5	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	10.1038/s41467-023-40064-9
		65863	21237	57	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1201196	21237	57	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		2774	10640	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		5593	10640	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		7319	10640	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		CHEMBL1200604	10640	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		DB00809	10640	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		DB01199	10640	95	None	-1	10	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	10.1038/s41467-023-40064-9
		2865	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		1935	10506	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		2551	10506	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		6687	10506	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL95	10506	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00382	10506	97	None	-977	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1038/s41467-023-40064-9
		1971	9641	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		2404	9641	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		4543	9641	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL445	9641	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		DB00540	9641	38	None	-9	30	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		3157	8252	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	8252	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	8252	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	8252	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	8252	71	None	-	12	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		2600	10551	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	10551	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	10551	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	10551	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	10551	74	None	-	13	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		19861	214302	50	None	-	1	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL946	214302	50	None	-	1	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
		4976	210358	29	None	-1	12	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL668	210358	29	None	-1	12	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
		135409453	10545	41	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	10545	41	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	10545	41	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		448537	167029	89	None	-	25	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL411	167029	89	None	-	25	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		71329	186048	102	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	11	2	6	2.0	CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
		CHEMBL473	186048	102	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	441	11	2	6	2.0	CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
		27901	84982	22	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL2105458	84982	22	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		4822	51806	47	None	-	1	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL152408	51806	47	None	-	1	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		26987	7736	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	7736	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	7736	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	7736	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	7736	33	None	-102	21	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		3236	74383	43	None	1	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1902981	74383	43	None	1	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
		1371	8704	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		24199	8704	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		323	8704	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1201325	8704	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		DB06787	8704	11	None	-4	5	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	10.1038/s41467-023-40064-9
		3047788	84971	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL2105148	84971	15	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	271	3	0	2	3.3	CC1(CCN2CCCCC2)C(=O)CCc2ccccc21	10.1038/s41467-023-40064-9
		2865	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	10915	73	None	-1659	53	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		5329102	201505	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	201505	86	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		135398737	7745	93	None	-22	90	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	7745	93	None	-22	90	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	7745	93	None	-22	90	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	7745	93	None	-22	90	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	7745	93	None	-22	90	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		1613	9127	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	9127	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	9127	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	9127	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	9127	53	None	-42	44	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		115368	9830	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		2112	9830	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		7556	9830	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1472975	9830	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		DB08922	9830	47	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		124087	8171	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	8171	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	8171	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	8171	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	8171	114	None	-6	15	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		1979	84101	70	None	-2	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL20835	84101	70	None	-2	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	10.1038/s41467-023-40064-9
		12488	8438	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		941361	8438	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		CHEMBL30008	8438	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		DB04841	8438	56	None	-	23	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		3033538	8101	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		7155	8101	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		781	8101	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1201216	8101	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		DB00298	8101	39	None	-	9	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
		237	211644	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL546257	211644	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL554190	211644	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL7568	211644	48	None	-1	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		21855	91021	42	None	-7	6	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL22108	91021	42	None	-7	6	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		2771	201796	74	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	201796	74	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	201796	74	None	-	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		34040	34858	72	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		CHEMBL1372950	34858	72	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		6834	212331	45	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL811	212331	45	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		3000322	10335	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		330	10335	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		CHEMBL569713	10335	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		DB00747	10335	38	None	-5	6	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	10.1038/s41467-023-40064-9
		2705	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		360	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		443879	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		CHEMBL1382	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		DB01036	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		2705	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		360	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		443879	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		CHEMBL1382	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		DB01036	10614	64	None	-1	10	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
		1605	9121	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		3957	9121	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		7216	9121	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		CHEMBL998	9121	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		DB00455	9121	117	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
		1224	8214	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		3100	8214	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		8980	8214	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		916	8214	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL657	8214	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		DB01075	8214	83	None	-6	13	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
		2551	7581	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		298	7581	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		488	7581	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		CHEMBL965	7581	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		DB00411	7581	23	None	-6	11	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
		2683	109665	25	None	-5	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL305906	109665	25	None	-5	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL334255	109665	25	None	-5	16	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		135398745	9688	112	None	-38	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	9688	112	None	-38	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	9688	112	None	-38	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	9688	112	None	-38	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		5205	84962	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL2104895	84962	58	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		1227	9267	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		2331	9267	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		3957	9267	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		4992	9267	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL511	9267	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		DB06691	9267	43	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		2337	10030	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	10030	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	10030	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	10030	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	10030	77	None	-31	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		1560	9089	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		5359371	9089	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		7209	9089	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1254682	9089	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		DB00504	9089	20	None	-	5	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	283	2	1	2	3.6	C=CCN1CC[C@@]23[C@H]([C@H]1Cc1c3cc(cc1)O)CCCC2	10.1038/s41467-023-40064-9
		1353	8692	93	None	-5011	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	8692	93	None	-5011	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	8692	93	None	-5011	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	8692	93	None	-5011	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	8692	93	None	-5011	85	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		2028	9753	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		359	9753	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		4634	9753	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		CHEMBL1231	9753	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		DB01062	9753	80	None	-8	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
		1400	8738	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		3658	8738	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		7199	8738	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		91513	8738	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL896	8738	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		DB00557	8738	70	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
		180	7189	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	7189	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	7189	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	7189	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	7189	56	None	-27	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		98941	53724	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL154126	53724	17	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		9880	37714	61	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	416	2	0	4	4.6	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL139835	37714	61	None	-	2	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	416	2	0	4	4.6	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		54697325	65753	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
		CHEMBL1689772	65753	35	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	556	6	6	10	1.3	CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O	10.1038/s41467-023-40064-9
		26987	7736	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	7736	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	7736	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	7736	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	7736	33	None	-102	21	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		25102847	84996	93	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
		CHEMBL2105717	84996	93	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
		3055	8215	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		313	8215	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		7163	8215	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL936	8215	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		DB01231	8215	44	None	-2	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		5832	21232	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		CHEMBL1201146	21232	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
		9417	140290	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL1524185	140290	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL370753	140290	54	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		135	9310	43	None	-25	56	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	9310	43	None	-25	56	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	9310	43	None	-25	56	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	9310	43	None	-25	56	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	9310	43	None	-25	56	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1726	9275	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		1993	9275	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		7438	9275	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		CHEMBL978	9275	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		DB06709	9275	13	None	-2	5	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1038/s41467-023-40064-9
		2520	210787	70	None	-	12	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1280	210787	70	None	-	12	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL6966	210787	70	None	-	12	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		2284	9956	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		4926	9956	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		7281	9956	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL564	9956	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00420	9956	33	None	-21	29	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation countingBinding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		10104167	8840	2	None	-	4	Guinea pig	10.1	pEC50	=	10.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		6937	8840	2	None	-	4	Guinea pig	10.1	pEC50	=	10.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		CHEMBL3121473	8840	2	None	-	4	Guinea pig	10.1	pEC50	=	10.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		10104167	8840	2	None	-	4	Guinea pig	9.8	pEC50	=	9.8	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		6937	8840	2	None	-	4	Guinea pig	9.8	pEC50	=	9.8	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		CHEMBL3121473	8840	2	None	-	4	Guinea pig	9.8	pEC50	=	9.8	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1016/j.ejmech.2014.01.032
		405242	18739	1	None	-	0	Pig	9.3	pEC50	=	9.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1182967	18739	1	None	-	0	Pig	9.3	pEC50	=	9.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL274413	18739	1	None	-	0	Pig	9.3	pEC50	=	9.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		23657685	20591	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1195729	20591	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1203986	20591	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		23657685	20591	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1195729	20591	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1203986	20591	0	None	-	0	Pig	9.1	pEC50	=	9.1	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	719	23	3	6	7.1	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)c1	10.1021/jm070859s
		44435840	20592	0	None	-	0	Pig	9.0	pEC50	=	9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1195736	20592	0	None	-	0	Pig	9.0	pEC50	=	9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL555247	20592	0	None	-	0	Pig	9.0	pEC50	=	9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		44435840	20592	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1195736	20592	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL555247	20592	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	897	30	3	7	9.0	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		11600184	19075	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
		CHEMBL1184960	19075	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
		CHEMBL380572	19075	0	None	-	0	Pig	9.0	pEC50	=	9.0	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	14	0	5	5.2	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOc1ccon1	10.1021/jm050769s
		23657683	20520	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1195234	20520	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1203985	20520	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		23657683	20520	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1195234	20520	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1203985	20520	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	574	16	3	5	5.8	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1	10.1021/jm070859s
		44435838	19839	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1190118	19839	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1203984	19839	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		44435838	19839	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1190118	19839	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		CHEMBL1203984	19839	0	None	-	0	Pig	8.9	pEC50	=	8.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	863	30	3	7	8.3	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1OCC[N+](CC)(CC)CC	10.1021/jm070859s
		23657687	19838	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1190117	19838	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL540132	19838	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		23657687	19838	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL1190117	19838	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		CHEMBL540132	19838	0	None	-	0	Pig	8.8	pEC50	=	8.8	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	752	23	3	6	7.7	CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1	10.1021/jm070859s
		10653182	105915	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
		CHEMBL265482	105915	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
		CHEMBL281080	105915	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm021077w
		2370	7410	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		297	7410	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		358	7410	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		CHEMBL1482	7410	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		DB01019	7410	31	None	-	5	Guinea pig	6.0	pEC50	=	6	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		167962	10841	4	None	-	1	Human	6.0	pEC50	=	6	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
		362	10841	4	None	-	1	Human	6.0	pEC50	=	6	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
		CHEMBL31599	10841	4	None	-	1	Human	6.0	pEC50	=	6	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm020871e
		10653182	105915	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
		CHEMBL265482	105915	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
		CHEMBL281080	105915	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	700	19	0	2	8.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1Cc1ccccc1)CCCN1C(=O)c2ccccc2C1Cc1ccccc1	10.1021/jm991136e
		2166	9897	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		305	9897	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		5910	9897	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		CHEMBL550	9897	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		DB01085	9897	49	None	-34	8	Human	6.0	pEC50	=	6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1021/acs.jnatprod.2c01079
		10437519	113698	0	None	-	0	Pig	5.0	pEC50	=	5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	389	12	0	2	3.4	CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31475	113698	0	None	-	0	Pig	5.0	pEC50	=	5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	389	12	0	2	3.4	CC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		76328902	113295	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121475	113295	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140248	113295	0	None	-	0	Guinea pig	7.0	pEC50	=	7.0	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL5287096	201392	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
		CHEMBL5315302	201392	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
		44408941	18587	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1182020	18587	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL206666	18587	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		118714969	127621	0	None	-	0	Pig	8.0	pEC50	=	8.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		CHEMBL3337859	127621	0	None	-	0	Pig	8.0	pEC50	=	8.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		CHEMBL3558417	127621	0	None	-	0	Pig	8.0	pEC50	=	8.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	652	4	0	4	5.6	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		46878254	21010	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1199299	21010	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		CHEMBL607178	21010	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		60138187	113225	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		60138192	113225	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121479	113225	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3139879	113225	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		135544402	119885	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		135597270	119885	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL1202147	119885	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL33142	119885	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	1	4	4.0	O/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		11613432	19080	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1184988	19080	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL382243	19080	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		44265572	105448	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL262448	105448	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL27743	105448	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		44265572	105448	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL262448	105448	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL27743	105448	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		10077281	110884	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL30939	110884	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL8653	110884	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		44318743	112726	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	584	0	0	6	4.3	C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/s0960-894x(00)00509-6
		CHEMBL312920	112726	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	584	0	0	6	4.3	C1=C2CN3CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2C23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/s0960-894x(00)00509-6
		118714976	127623	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337863	127623	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558421	127623	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		76328902	113295	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121475	113295	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140248	113295	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	512	14	0	5	3.5	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		118714976	127623	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337863	127623	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558421	127623	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	654	7	1	3	6.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		187	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		11828809	18730	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL1182934	18730	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL273255	18730	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	618	15	0	4	5.7	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		134207697	181058	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	428	3	2	7	3.0	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		CHEMBL4549515	181058	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	428	3	2	7	3.0	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5ccc(F)c(F)c5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		10438106	106433	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL1202149	106433	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL284370	106433	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	415	8	0	2	4.5	Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		44279262	112851	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	522	16	0	4	3.2	C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C	10.1021/jm021077w
		CHEMBL31336	112851	0	None	-	0	Pig	4.9	pEC50	=	4.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	522	16	0	4	3.2	C[C@@H]1C(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)[C@H](C)[C@@H](C)C2=O)C(=O)[C@H]1C	10.1021/jm021077w
		10795567	106611	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
		CHEMBL285598	106611	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
		CHEMBL303052	106611	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm021077w
		10795567	106611	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
		CHEMBL285598	106611	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
		CHEMBL303052	106611	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	668	19	0	4	8.1	CC(C)SC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1SC(C)C	10.1021/jm991136e
		187	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	7043	39	None	6	9	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		167962	10841	4	None	-	1	Pig	7.9	pEC50	=	7.9	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
		362	10841	4	None	-	1	Pig	7.9	pEC50	=	7.9	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
		CHEMBL31599	10841	4	None	-	1	Pig	7.9	pEC50	=	7.9	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm050769s
		405252	18706	3	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1182747	18706	3	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL263972	18706	3	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		1273	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		3450	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		356	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		6172	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		67425	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		CHEMBL360055	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		DB00483	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		1273	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		3450	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		356	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		6172	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		67425	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		CHEMBL360055	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		DB00483	8535	16	None	-	3	Pig	6.9	pEC50	=	6.9	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/jm070859s
		168294767	199798	0	None	-1	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	199798	0	None	-1	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	199798	0	None	-1	20	Human	5.9	pEC50	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		10865495	24842	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		CHEMBL126655	24842	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		CHEMBL8898	24842	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		10865495	24842	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL126655	24842	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL8898	24842	0	None	-	0	Pig	6.9	pEC50	=	6.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		167962	10841	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
		362	10841	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
		CHEMBL31599	10841	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021017q
		10699850	106804	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL168760	106804	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL286892	106804	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL5272950	200519	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	166	2	1	3	0.5	O=C1C[C@@H](Cc2cnc[nH]2)CO1	10.1021/acs.jnatprod.2c01079
		10699850	106804	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL168760	106804	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL286892	106804	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	534	14	0	4	3.7	C[N+](C)(CCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		60138189	113297	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138190	113297	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121476	113297	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140252	113297	0	None	-	0	Guinea pig	7.9	pEC50	=	7.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		11007357	17857	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL1177962	17857	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL8721	17857	0	None	-	0	Pig	7.9	pEC50	=	7.9	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	668	15	0	4	6.8	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		10795468	18509	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181455	18509	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL171664	18509	0	None	-	0	Pig	5.9	pEC50	=	5.9	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	646	15	0	8	3.7	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		170332	167755	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	167755	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	167755	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		2370	7410	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		297	7410	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		358	7410	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		CHEMBL1482	7410	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		DB01019	7410	31	None	-	5	Guinea pig	5.9	pEC50	=	5.9	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	10.1016/j.ejmech.2014.01.032
		167962	10841	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
		362	10841	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
		CHEMBL31599	10841	4	None	-	1	Pig	5.9	pEC50	=	5.9	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm991136e
		170332	167755	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	167755	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	167755	1	None	3	3	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		167962	10841	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		362	10841	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		CHEMBL31599	10841	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		405254	112959	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL269205	112959	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL31380	112959	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		167962	10841	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		362	10841	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		CHEMBL31599	10841	4	None	-	1	Pig	5.8	pEC50	=	5.8	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		405254	112959	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL269205	112959	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31380	112959	1	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		44319261	19117	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		CHEMBL1185324	19117	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		CHEMBL407440	19117	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	866	4	0	4	10.0	C1=C2C[N+]3(Cc4ccc5ccccc5c4)CCC45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2C23CC[N+]4(Cc5ccc7ccccc7c5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		10629136	109128	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
		CHEMBL30376	109128	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
		CHEMBL68151	109128	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm021077w
		10629136	109128	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
		CHEMBL30376	109128	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
		CHEMBL68151	109128	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	636	19	0	4	6.6	CC(C)OC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC(C)C	10.1021/jm991136e
		10985389	18746	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL1183013	18746	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL275988	18746	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	550	15	0	6	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		187	7043	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		294	7043	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		65	7043	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		8593	7043	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		CHEMBL667	7043	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		DB03128	7043	39	None	6	9	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayAgonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jnatprod.2c01079
		44408892	81927	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL203627	81927	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		44265578	24734	2	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL126103	24734	2	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL268194	24734	2	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		44265578	24734	2	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL126103	24734	2	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL268194	24734	2	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	576	15	0	4	4.7	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		137629935	167799	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	167799	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	167799	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		10257778	123561	0	None	-	0	Pig	4.8	pEC50	=	4.8	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL1202150	123561	0	None	-	0	Pig	4.8	pEC50	=	4.8	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL33774	123561	0	None	-	0	Pig	4.8	pEC50	=	4.8	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	426	8	0	3	4.1	N#Cc1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		137629935	167799	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	167799	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	167799	0	None	1	3	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		44318815	19123	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL1185416	19123	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL412670	19123	0	None	-	0	Pig	5.8	pEC50	=	5.8	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	902	4	0	4	9.7	FC(F)(F)c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(C(F)(F)F)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		10974720	24757	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		CHEMBL126199	24757	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		CHEMBL9071	24757	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm020871e
		10974720	24757	0	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL126199	24757	0	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL9071	24757	0	None	-	0	Pig	6.8	pEC50	=	6.8	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		76325356	113289	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3120178	113289	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140233	113289	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		405246	18741	1	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1182976	18741	1	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL274564	18741	1	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	654	15	0	4	6.5	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		302	9751	25	None	-34	8	Human	7.7	pEC50	=	7.7	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
		4630	9751	25	None	-34	8	Human	7.7	pEC50	=	7.7	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
		CHEMBL7634	9751	25	None	-34	8	Human	7.7	pEC50	=	7.7	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00012a019
		187	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		10676698	18508	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181450	18508	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL171388	18508	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	618	13	0	8	3.0	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		187	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	7043	39	None	6	9	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assayAgonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arrestin recruitment after 24 hrs by Bright-Glo luminescence assay	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		10604576	112105	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
		CHEMBL303002	112105	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31162	112105	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm021077w
		10604576	112105	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
		CHEMBL303002	112105	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
		CHEMBL31162	112105	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	520	15	0	2	4.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1Cc2ccccc2C1=O)CCCN1Cc2ccccc2C1=O	10.1021/jm991136e
		21158560	119570	7	None	-	4	Pig	8.7	pEC50	=	8.7	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3305985	119570	7	None	-	4	Pig	8.7	pEC50	=	8.7	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		11527805	19079	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
		CHEMBL1184985	19079	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
		CHEMBL381913	19079	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	576	13	0	4	4.3	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O	10.1021/jm050769s
		11535022	18579	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
		CHEMBL1181943	18579	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
		CHEMBL199636	18579	0	None	-	0	Pig	8.6	pEC50	=	8.6	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	574	13	0	3	4.8	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1CCCC1=O	10.1021/jm050769s
		60138188	113227	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		60138191	113227	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121478	113227	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3139897	113227	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		44265574	17859	0	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL1177964	17859	0	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL8764	17859	0	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	5.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		405250	18611	1	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
		CHEMBL1182178	18611	1	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
		CHEMBL216974	18611	1	None	-	0	Pig	6.7	pEC50	=	6.7	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	648	15	0	4	6.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc3ccccc3cc2C1=O)CCCN1C(=O)c2cc3ccccc3cc2C1=O	10.1021/jm021017q
		76328904	113228	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3121480	113228	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3139898	113228	0	None	-	0	Guinea pig	7.7	pEC50	=	7.7	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		11585610	19081	0	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1184995	19081	0	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL382659	19081	0	None	-	0	Pig	7.7	pEC50	=	7.7	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	522	13	0	3	3.5	C[N+](C)(CCCCCC[N+]1(CC#CCN2CCCC2=O)CCCC1)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		11757557	106889	0	None	-	0	Pig	4.7	pEC50	=	4.7	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
		CHEMBL1202151	106889	0	None	-	0	Pig	4.7	pEC50	=	4.7	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
		CHEMBL287536	106889	0	None	-	0	Pig	4.7	pEC50	=	4.7	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	401	8	0	2	4.2	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCC[n+]2ccccc2)cc1	10.1021/jm00036a008
		44279470	109102	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	570	16	0	4	3.8	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O	10.1021/jm021077w
		CHEMBL30361	109102	0	None	-	0	Pig	5.7	pEC50	=	5.7	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	570	16	0	4	3.8	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O)CCCN1C(=O)[C@H]2CC=CC[C@H]2C1=O	10.1021/jm021077w
		11094083	17860	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
		CHEMBL1177968	17860	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
		CHEMBL8855	17860	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)CCCN1C(=O)c2cc(Cl)c(Cl)cc2C1=O	10.1021/jm021017q
		11613432	19080	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1184988	19080	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL382243	19080	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	402	4	0	2	4.4	C[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		10747747	105853	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
		CHEMBL280535	105853	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
		CHEMBL304129	105853	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm021077w
		10747747	105853	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
		CHEMBL280535	105853	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
		CHEMBL304129	105853	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	608	19	0	4	5.9	CCOC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OCC	10.1021/jm991136e
		44408941	18587	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1182020	18587	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL206666	18587	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer	ChEMBL	454	8	0	2	5.5	C=CC[N+](C)(C)Cc1c2n(c3ccccc13)Cc1c(C[N+](C)(C)CC=C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		10483419	118123	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL32689	118123	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL539621	118123	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	423	11	0	2	5.1	CC[N+](CC)(CC)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		10771150	18510	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181457	18510	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL171776	18510	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	3.4	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		44278967	106546	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	549	15	0	5	3.5	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL285136	106546	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	549	15	0	5	3.5	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccnc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		137629935	167799	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	167799	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	167799	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		44279153	113788	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	333	10	1	3	2.3	C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31533	113788	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	333	10	1	3	2.3	C[N+](C)(CCCCCCO)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		137629935	167799	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	167799	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	167799	0	None	1	3	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		2230	7253	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
		296	7253	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
		CHEMBL7303	7253	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
		DB04365	7253	60	None	-75	10	Human	7.6	pEC50	=	7.6	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00012a019
		9987754	17853	0	None	-	0	Pig	7.6	pEC50	=	7.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL1177947	17853	0	None	-	0	Pig	7.6	pEC50	=	7.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL8449	17853	0	None	-	0	Pig	7.6	pEC50	=	7.6	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	612	15	0	4	5.5	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		10007510	116472	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL1202152	116472	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL32278	116472	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	381	8	0	2	3.9	C[N+](C)(C)CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL5287159	201398	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	560	13	1	4	4.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[n+]1c[nH]c(CC2COC(=O)C2)c1	10.1021/acs.jnatprod.2c01079
		CHEMBL5315392	201398	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	560	13	1	4	4.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[n+]1c[nH]c(CC2COC(=O)C2)c1	10.1021/acs.jnatprod.2c01079
		118714979	127624	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337866	127624	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558422	127624	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		10319023	118120	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	323	6	0	2	4.2	CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		CHEMBL32688	118120	0	None	-	0	Pig	4.6	pEC50	=	4.6	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	323	6	0	2	4.2	CCC[n+]1ccc(/C=N/OCc2c(Cl)cccc2Cl)cc1	10.1021/jm00036a008
		118714979	127624	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337866	127624	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558422	127624	0	None	-	0	Pig	6.6	pEC50	=	6.6	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	586	2	0	2	6.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		10770828	114368	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL165814	114368	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL31895	114368	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		10770828	114368	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL165814	114368	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31895	114368	0	None	-	0	Pig	5.6	pEC50	=	5.6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	520	13	0	4	3.3	C[N+](C)(CCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		154734599	9281	12	None	-	12	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
		327	9281	12	None	-	12	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
		4108	9281	12	None	-	12	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
		CHEMBL27673	9281	12	None	-	12	Pig	5.5	pEC50	=	5.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm021077w
		44319052	18842	0	None	-	0	Pig	8.5	pEC50	=	8.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1183674	18842	0	None	-	0	Pig	8.5	pEC50	=	8.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL311649	18842	0	None	-	0	Pig	8.5	pEC50	=	8.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	666	4	0	4	5.7	C=CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC=C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		44319054	18846	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1183713	18846	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL314491	18846	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	670	4	0	4	6.1	CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCC)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		11115491	18697	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL1182715	18697	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL262449	18697	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	660	15	0	4	6.7	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccc(C(C)(C)C)cc3C1=O)C2=O	10.1021/jm021017q
		44265538	17861	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL1177969	17861	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8900	17861	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.4	CC(C)(C)c1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		2520	210787	70	None	-	12	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
		CHEMBL1280	210787	70	None	-	12	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
		CHEMBL6966	210787	70	None	-	12	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1021/jm021077w
		118720626	127630	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3355097	127630	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558555	127630	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		44318760	19113	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL1185295	19113	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL405691	19113	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	856	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		44279242	112359	0	None	-	0	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	494	16	0	4	2.7	CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O	10.1021/jm021077w
		CHEMBL31221	112359	0	None	-	0	Pig	4.5	pEC50	=	4.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	494	16	0	4	2.7	CC1CC(=O)N(CCC[N+](C)(C)CCCCCCC[N+](C)(C)CCCN2C(=O)CC(C)C2=O)C1=O	10.1021/jm021077w
		118720626	127630	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3355097	127630	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558555	127630	0	None	-	0	Pig	7.5	pEC50	=	7.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	844	9	1	7	8.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		118714974	127622	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337862	127622	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558420	127622	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		44265563	106636	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
		CHEMBL285811	106636	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
		CHEMBL8491	106636	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021077w
		44265563	106636	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL285811	106636	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL8491	106636	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		118714974	127622	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337862	127622	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558420	127622	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	602	3	1	3	5.6	CC[C@@H]1C[N+]2(C)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C[C@H]7CCO)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		44265563	106636	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL285811	106636	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8491	106636	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	562	15	0	4	4.4	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		118714971	127617	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
		CHEMBL3337860	127617	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
		CHEMBL3558367	127617	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	842	6	0	8	7.5	O=[N+]([O-])c1ccc(C[N+]23CC[C@]45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4[C@@]45CC[N+]7(Cc8ccc([N+](=O)[O-])cc8)CC8=CO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1021/np500259j
		44319263	19126	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
		CHEMBL1185419	19126	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
		CHEMBL412718	19126	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	886	8	0	8	7.7	COc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(OC)c(OC)c8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1OC	10.1016/s0960-894x(00)00509-6
		10556700	19011	0	None	-	0	Pig	5.5	pEC50	=	5.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184494	19011	0	None	-	0	Pig	5.5	pEC50	=	5.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL352356	19011	0	None	-	0	Pig	5.5	pEC50	=	5.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	546	10	0	4	3.0	O=C1c2ccccc2C(=O)N1CC[n+]1ccc(CCCc2cc[n+](CCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10843180	18505	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181400	18505	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169638	18505	0	None	-	0	Pig	6.5	pEC50	=	6.5	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	674	17	0	8	3.8	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		118714981	127625	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337867	127625	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558423	127625	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		11828771	23510	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL124330	23510	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL8729	23510	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		118714981	127625	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337867	127625	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558423	127625	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	638	6	0	2	7.7	C=CC[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(CC=C)C[C@H]7CC)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)[C@H](CC)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		11115442	19114	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL1185309	19114	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL406431	19114	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		11828771	23510	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL124330	23510	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8729	23510	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	604	15	0	4	5.3	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		168057	7995	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		7634	7995	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		CHEMBL28407	7995	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm981023f
		44318758	19089	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1185047	19089	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL385915	19089	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	960	8	0	8	6.7	O=C1c2ccccc2C(=O)N1CCC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CCCN7C(=O)c8ccccc8C7=O)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		76321739	113226	0	None	-	0	Guinea pig	7.4	pEC50	=	7.4	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3121477	113226	0	None	-	0	Guinea pig	7.4	pEC50	=	7.4	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3139896	113226	0	None	-	0	Guinea pig	7.4	pEC50	=	7.4	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		10699593	106189	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL282782	106189	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL353262	106189	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		10699593	106189	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL282782	106189	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL353262	106189	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	506	12	0	4	2.9	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		168057	7995	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		7634	7995	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		CHEMBL28407	7995	11	None	-	1	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/jm021077w
		44279691	106517	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	664	15	0	4	5.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL284962	106517	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	664	15	0	4	5.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)CC2c3ccccc3C(C1=O)c1ccccc12)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10909212	19143	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
		CHEMBL1185516	19143	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
		CHEMBL418702	19143	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	804	15	0	4	7.3	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O)CCCN1C(=O)C2C3c4ccccc4C(c4ccccc43)C2C1=O	10.1021/jm021017q
		44319178	19179	0	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1185797	19179	0	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL433343	19179	0	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	662	2	0	4	4.6	C#CC[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(CC#C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		405242	18739	1	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL1182967	18739	1	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL274413	18739	1	None	-	0	Pig	8.4	pEC50	=	8.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		23657556	19837	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1190116	19837	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL540131	19837	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		118714972	121367	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
		CHEMBL3337861	121367	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
		10442337	210727	2	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	182	2	1	4	1.1	CCOc1noc2c1CNCCC2	10.1021/jm00012a019
		CHEMBL69305	210727	2	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	182	2	1	4	1.1	CCOc1noc2c1CNCCC2	10.1021/jm00012a019
		118714972	121367	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
		CHEMBL3337861	121367	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	572	3	1	5	5.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CCO	10.1021/np500259j
		10461289	119481	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL1202148	119481	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL33044	119481	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	444	9	0	3	4.3	CN(C)c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		10442081	109385	9	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	168	1	1	4	0.7	COc1noc2c1CNCCC2	10.1021/jm00012a019
		CHEMBL304142	109385	9	None	-	0	Human	7.4	pEC50	=	7.4	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	168	1	1	4	0.7	COc1noc2c1CNCCC2	10.1021/jm00012a019
		168927	146947	7	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1021/np500259j
		CHEMBL380352	146947	7	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1021/np500259j
		168927	146947	7	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/j.bmcl.2005.12.030
		CHEMBL380352	146947	7	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	584	0	0	6	4.3	C1=C2CN3CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@H]35)[C@@H](OC1)N1c2ccccc2[C@@]23CCN4CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@H]43	10.1016/j.bmcl.2005.12.030
		10009514	208948	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	654	17	0	6	7.2	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCCCC1)C1CCCCC1	10.1021/jm021077w
		CHEMBL609382	208948	0	None	-	0	Pig	7.4	pEC50	=	7.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	654	17	0	6	7.2	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCN1C(=O)c2ccccc2C1=O)C1CCCCC1)C1CCCCC1	10.1021/jm021077w
		10974913	17863	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
		CHEMBL1177971	17863	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
		CHEMBL9017	17863	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	684	15	0	4	6.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O	10.1021/jm021017q
		44408892	81927	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		CHEMBL203627	81927	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	372	4	0	4	4.1	CN(C)Cc1c2n(c3ccccc13)Cc1c(CN(C)C)c3ccccc3n1C2	10.1016/j.bmcl.2005.12.030
		44279471	106769	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O	10.1021/jm021077w
		CHEMBL286686	106769	0	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@H]2C1=O	10.1021/jm021077w
		10032676	18504	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181399	18504	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169633	18504	0	None	-	0	Pig	6.4	pEC50	=	6.4	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	702	19	0	8	4.6	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10077592	123360	1	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	458	10	0	4	4.2	CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL33656	123360	1	None	-	0	Pig	5.4	pEC50	=	5.4	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	458	10	0	4	4.2	CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		44265498	118100	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL32676	118100	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL8669	118100	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		44265498	118100	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL32676	118100	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL8669	118100	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	584	15	0	4	4.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		76328904	113228	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3121480	113228	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3139898	113228	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	560	10	0	5	4.4	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3cccc4cccc(c34)C2=O)CC1	10.1016/j.ejmech.2014.01.032
		10009225	103288	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL262632	103288	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL8531	103288	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm020871e
		10009225	103288	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL262632	103288	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8531	103288	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	632	15	0	4	6.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccc(C)cc3C1=O)C2=O	10.1021/jm021017q
		10747449	19018	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184538	19018	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL354750	19018	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	560	11	0	4	4.1	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(-c2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10461019	19012	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184498	19012	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL352486	19012	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	588	13	0	4	4.2	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10101670	8291	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
		7635	8291	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
		CHEMBL32985	8291	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	602	12	0	4	7.1	Clc1cccc(c1CO/N=C/c1cc[n+](cc1)CCC[n+]1ccc(cc1)/C=N/OCc1c(Cl)cccc1Cl)Cl	10.1021/jm00036a008
		118720628	127631	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3355098	127631	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558556	127631	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		10509176	19017	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184534	19017	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL354673	19017	0	None	-	0	Pig	5.3	pEC50	=	5.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	574	12	0	4	3.8	O=C1c2ccccc2C(=O)N1CCC[n+]1ccc(CCCc2cc[n+](CCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		118720628	127631	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3355098	127631	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558556	127631	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	828	8	0	6	9.5	CC[C@@H]1C[N+]2(Cc3ccc([N+](=O)[O-])cc3)CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(Cc8ccc([N+](=O)[O-])cc8)C[C@H]7CC)c7ccccc7N(/C=C(/[C@H]1C[C@@H]32)[C@H]54)[C@@H]69	10.1021/np500259j
		23657556	19837	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL1190116	19837	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		CHEMBL540131	19837	0	None	-	0	Pig	8.3	pEC50	=	8.3	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	608	16	3	5	6.5	CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1	10.1021/jm070859s
		76325356	113289	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3120178	113289	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140233	113289	0	None	-	0	Guinea pig	7.3	pEC50	=	7.3	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	562	14	0	5	4.7	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		11505653	19082	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1185000	19082	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL382846	19082	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	14	0	5	3.5	C[N+](C)(CC#CCOc1ccon1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		118714977	121368	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
		CHEMBL3337865	121368	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
		118714977	121368	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
		CHEMBL3337865	121368	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	556	2	0	4	6.3	CC[C@@H]1CN2CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@@H]8N(CC[C@@]89c8ccccc8N(/C=C(/[C@H]1C[C@H]23)[C@H]54)[C@@H]69)C[C@H]7CC	10.1021/np500259j
		10963807	17852	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL1177938	17852	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		CHEMBL7902	17852	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	616	15	0	4	5.1	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccc(C(F)(F)F)cc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021017q
		44319265	19116	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL1185319	19116	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		CHEMBL407071	19116	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	922	4	0	4	9.2	Brc1ccc(C[N+]23CCC45c6ccccc6N6[C@H]4[C@H]4[C@@H](C[C@@H]52)C(=CCO[C@H]4N2c4ccccc4C45CC[N+]7(Cc8ccc(Br)cc8)CC8=CCO[C@@H]6[C@@H]([C@H]24)[C@H]8C[C@@H]57)C3)cc1	10.1016/s0960-894x(00)00509-6
		10794637	18500	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181384	18500	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169133	18500	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	518	8	0	4	2.9	O=C1c2ccccc2C(=O)N1C[n+]1ccc(CCCc2cc[n+](CN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		44381306	18501	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181388	18501	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169342	18501	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	12	0	8	2.6	O=C1c2ccccc2C(=O)N1CO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10843237	19016	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1184525	19016	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL354103	19016	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	688	18	0	8	4.2	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCCCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		11104735	17854	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1177953	17854	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL8518	17854	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	626	15	0	4	5.9	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		10676884	18503	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181392	18503	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL169475	18503	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	660	16	0	8	3.4	O=C1c2ccccc2C(=O)N1CCCO/N=C/c1cc[n+](CCC[n+]2ccc(/C=N/OCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		10509365	113658	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31452	113658	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL352323	113658	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10509365	113658	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL31452	113658	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL352323	113658	0	None	-	0	Pig	6.3	pEC50	=	6.3	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	604	19	0	4	5.6	C[N+](C)(CCCCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL5285668	201409	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
		CHEMBL5315497	201409	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assayPartial agonist activity at C-terminal NanoLuc tagged human muscarinic M2 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay	ChEMBL	602	14	0	5	5.2	CC[C@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C	10.1021/acs.jnatprod.2c01079
		10069369	106480	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	317	9	0	2	3.3	CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL284672	106480	0	None	-	0	Pig	4.3	pEC50	=	4.3	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	317	9	0	2	3.3	CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10348407	23068	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL122499	23068	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL267482	23068	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		10348407	23068	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL122499	23068	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL267482	23068	0	None	-	0	Pig	7.3	pEC50	=	7.3	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		10818763	113764	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL169001	113764	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL31518	113764	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		10818763	113764	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL169001	113764	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31518	113764	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	576	17	0	4	4.9	C[N+](C)(CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		11422540	208913	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	682	17	0	6	7.8	Cc1ccc2c(c1)C(=O)N(CCCN(CCCCCCN(CCCN1C(=O)c3ccc(C)cc3C1=O)C1CCCCC1)C1CCCCC1)C2=O	10.1021/jm021077w
		CHEMBL609120	208913	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	682	17	0	6	7.8	Cc1ccc2c(c1)C(=O)N(CCCN(CCCCCCN(CCCN1C(=O)c3ccc(C)cc3C1=O)C1CCCCC1)C1CCCCC1)C2=O	10.1021/jm021077w
		10261985	210728	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	192	2	1	4	0.7	C#CCOc1noc2c1CNCCC2	10.1021/jm00012a019
		CHEMBL69306	210728	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	192	2	1	4	0.7	C#CCOc1noc2c1CNCCC2	10.1021/jm00012a019
		11671915	18575	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1181935	18575	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL197604	18575	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	496	13	0	3	3.0	C[N+](C)(CC#CCN1CCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		134207690	181424	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	434	4	2	9	2.4	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cnc(C6CC6)nc5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		CHEMBL4558206	181424	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	434	4	2	9	2.4	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cnc(C6CC6)nc5)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		11756054	117641	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	429	9	0	3	5.5	COc1ccc(CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		CHEMBL32609	117641	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	429	9	0	3	5.5	COc1ccc(CCC[n+]2ccc(/C=N/OCc3c(Cl)cccc3Cl)cc2)cc1	10.1021/jm00036a008
		10747380	111644	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
		CHEMBL31103	111644	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
		CHEMBL68393	111644	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm021077w
		10747380	111644	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
		CHEMBL31103	111644	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
		CHEMBL68393	111644	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	552	15	2	4	3.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1O)CCCN1C(=O)c2ccccc2C1O	10.1021/jm991136e
		10077281	110884	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL30939	110884	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL8653	110884	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	598	15	0	4	5.2	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10509354	18499	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL1181373	18499	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		CHEMBL168613	18499	0	None	-	0	Pig	6.2	pEC50	=	6.2	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	602	14	0	4	4.6	O=C1c2ccccc2C(=O)N1CCCC[n+]1ccc(CCCc2cc[n+](CCCCN3C(=O)c4ccccc4C3=O)cc2)cc1	10.1021/jm981023f
		1935	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		2551	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		6687	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		CHEMBL95	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		DB00382	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		11083080	17858	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
		CHEMBL1177963	17858	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
		CHEMBL8763	17858	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	552	15	0	8	1.7	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2nccnc2C1=O)CCCN1C(=O)c2nccnc2C1=O	10.1021/jm021017q
		1935	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		2551	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		6687	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		CHEMBL95	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		DB00382	10506	97	None	-	6	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptorInhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm070859s
		53382542	93088	0	None	-	0	Rat	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine responsePositive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
		CHEMBL2313377	93088	0	None	-	0	Rat	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine responsePositive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response	ChEMBL	295	2	2	4	3.0	Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl	10.1016/j.bmcl.2012.10.073
		134207682	180423	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	461	3	2	8	3.5	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cc(Cl)ncc5Cl)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		CHEMBL4534301	180423	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulation of human M2 AchRPositive allosteric modulation of human M2 AchR	ChEMBL	461	3	2	8	3.5	Cc1nc2cc(C)c3c(N)c(C(=O)NC4CN(c5cc(Cl)ncc5Cl)C4)sc3n2n1	10.1016/j.bmcl.2019.06.032
		10055492	112954	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		CHEMBL31376	112954	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		CHEMBL3350263	112954	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		11504244	113296	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138185	113296	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121474	113296	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140249	113296	0	None	-	2	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		10055492	112954	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		CHEMBL31376	112954	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		CHEMBL3350263	112954	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		10818794	108944	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
		CHEMBL30264	108944	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
		CHEMBL73114	108944	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm021077w
		10818794	108944	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
		CHEMBL30264	108944	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
		CHEMBL73114	108944	0	None	-	0	Pig	5.2	pEC50	=	5.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	580	17	0	4	5.1	COC1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1OC	10.1021/jm991136e
		71717892	95853	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		CHEMBL2311018	95853	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		CHEMBL2365146	95853	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	766	4	0	4	7.7	C1=C2C[N@+]3(Cc4ccccc4)CC[C@]45c6ccccc6N6[C@H]4[C@@H]([C@H]2C[C@@H]53)[C@@H](OC1)N1c2ccccc2[C@@]23CC[N@@+]4(Cc5ccccc5)CC5=CCO[C@@H]6[C@@H]([C@H]12)[C@H]5C[C@@H]34	10.1016/s0960-894x(00)00509-6
		76321739	113226	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3121477	113226	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		CHEMBL3139896	113226	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	510	10	0	5	3.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+]1(C)CCC(N2C(=O)c3ccccc3C2=O)CC1	10.1016/j.ejmech.2014.01.032
		60138189	113297	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138190	113297	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121476	113297	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140252	113297	0	None	-	0	Guinea pig	7.2	pEC50	=	7.2	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	526	15	0	5	3.9	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138187	113225	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		60138192	113225	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121479	113225	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3139879	113225	0	None	-	0	Guinea pig	8.2	pEC50	=	8.2	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	576	15	0	5	5.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		405244	19115	1	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL1185313	19115	1	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		CHEMBL406691	19115	1	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	640	15	0	4	6.2	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3cccc4cccc(c34)C1=O)C2=O	10.1021/jm021017q
		60138188	113227	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		60138191	113227	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121478	113227	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3139897	113227	0	None	-	0	Guinea pig	8.1	pEC50	=	8.1	Binding	Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response	ChEMBL	548	13	0	5	4.3	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1016/j.ejmech.2014.01.032
		11768033	18723	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1182845	18723	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL269592	18723	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	676	15	0	4	7.0	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		10843266	117340	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
		CHEMBL32530	117340	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
		CHEMBL68936	117340	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm021077w
		10985526	25593	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL127933	25593	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		CHEMBL8983	25593	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Binding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reportedBinding of [3H]N-methylscopolamine at porcine heart Muscarinic acetylcholine receptor M2 that inhibits the dissociation of [3H]NMS half maximally (pEC50diss) was reported	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm020871e
		10985526	25593	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL127933	25593	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		CHEMBL8983	25593	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	590	15	0	4	5.0	Cc1ccc2c(c1)C(=O)N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c3ccccc3C1=O)C2=O	10.1021/jm021017q
		10843266	117340	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
		CHEMBL32530	117340	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
		CHEMBL68936	117340	0	None	-	0	Pig	7.2	pEC50	=	7.2	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C\c1ccccc1	10.1021/jm991136e
		11353863	208914	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	596	19	0	8	4.4	N#CCCN(CCCCCCN(CCC#N)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL609124	208914	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	596	19	0	8	4.4	N#CCCN(CCCCCCN(CCC#N)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		2551	7581	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		298	7581	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		488	7581	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		CHEMBL965	7581	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		DB00411	7581	23	None	-6	11	Human	7.1	pEC50	=	7.1	Binding	In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00012a019
		132986	106389	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	702	17	2	4	7.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1c2ccccc2C(=O)NC1c1ccccc1)CCCN1c2ccccc2C(=O)NC1c1ccccc1	10.1021/jm021077w
		CHEMBL284055	106389	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	702	17	2	4	7.4	C[N+](C)(CCCCCC[N+](C)(C)CCCN1c2ccccc2C(=O)NC1c1ccccc1)CCCN1c2ccccc2C(=O)NC1c1ccccc1	10.1021/jm021077w
		405248	18717	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
		CHEMBL1182821	18717	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
		CHEMBL268195	18717	1	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	620	15	0	4	4.6	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2cc(F)c(F)cc2C1=O)CCCN1C(=O)c2cc(F)c(F)cc2C1=O	10.1021/jm021017q
		10509706	103215	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
		CHEMBL262124	103215	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
		CHEMBL303624	103215	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm021077w
		10509706	103215	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
		CHEMBL262124	103215	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
		CHEMBL303624	103215	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	672	17	0	2	8.0	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1c1ccccc1)CCCN1C(=O)c2ccccc2C1c1ccccc1	10.1021/jm991136e
		10348116	111595	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@@H]2C1=O	10.1021/jm021077w
		CHEMBL31097	111595	0	None	-	0	Pig	6.1	pEC50	=	6.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	574	16	0	4	4.2	C[N+](C)(CCCCCCC[N+](C)(C)CCCN1C(=O)[C@@H]2CCCC[C@H]2C1=O)CCCN1C(=O)[C@H]2CCCC[C@@H]2C1=O	10.1021/jm021077w
		44319180	18850	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL1183728	18850	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		CHEMBL315340	18850	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	614	0	0	4	4.6	C[N+]12CCC34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3C34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/s0960-894x(00)00509-6
		118714967	127620	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		CHEMBL3337858	127620	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		CHEMBL3558416	127620	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	600	0	0	4	4.5	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1021/np500259j
		46878256	20936	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		CHEMBL1198561	20936	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		CHEMBL607179	20936	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi bufferInhibition of [3H]NMS dissociation from muscarinic M2 receptor in Na,K,Pi buffer	ChEMBL	614	0	0	4	4.6	C[N+]12CC[C@]34c5ccccc5N5[C@H]3[C@H]3[C@@H](C[C@@H]41)C(=CCO[C@H]3N1c3ccccc3[C@@]34CC[N+]6(C)CC7=CCO[C@@H]5[C@@H]([C@H]13)[C@H]7C[C@@H]46)C2	10.1016/j.bmcl.2005.12.030
		11115574	17856	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL1177955	17856	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		CHEMBL8532	17856	0	None	-	0	Pig	8.1	pEC50	=	8.1	Binding	Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.Effective concentration required to inhibit dissociation of [3H]NMS from porcine heart ventricles muscarinic acetylcholine receptor M2.	ChEMBL	704	15	0	4	7.7	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN1C(=O)c2cccc3cccc(c23)C1=O	10.1021/jm021017q
		2230	7253	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
		296	7253	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
		CHEMBL7303	7253	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
		DB04365	7253	60	None	-75	10	Human	7.1	pEC50	=	7.1	Binding	In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateIn vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00050a006
		11636025	18581	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL1181949	18581	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		CHEMBL201016	18581	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2Inhibition of [3H]NMS dissociation from porcine heart muscarinic receptor M2	ChEMBL	498	13	0	4	2.6	C[N+](C)(CC#CCN1OCCC1=O)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm050769s
		170332	167755	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	167755	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	167755	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		170332	167755	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	167755	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	167755	1	None	3	3	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assayAgonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins by alphascreen assay	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		10748143	106438	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		CHEMBL2111531	106438	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		CHEMBL284393	106438	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm021077w
		10748143	106438	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		CHEMBL2111531	106438	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		CHEMBL284393	106438	0	None	-	0	Pig	7.1	pEC50	=	7.1	Binding	Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptorsInhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors	ChEMBL	696	17	0	2	8.8	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2/C1=C/c1ccccc1	10.1021/jm991136e
		11504244	113296	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		60138185	113296	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3121474	113296	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		CHEMBL3140249	113296	0	None	-	2	Guinea pig	6.1	pEC50	=	6.1	Binding	Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseAgonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1016/j.ejmech.2014.01.032
		10767691	114536	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL171215	114536	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		CHEMBL31915	114536	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm021077w
		10767691	114536	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL171215	114536	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		CHEMBL31915	114536	0	None	-	0	Pig	5.1	pEC50	=	5.1	Binding	Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2Allosteric potency against the dissociation of radioligand [3H]N-methylscopolamine from the porcine cardiac Muscarinic acetylcholine receptor M2	ChEMBL	420	8	0	4	2.4	C[N+](C)(CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm981023f
		10050814	116570	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	399	8	0	2	5.5	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCCc2ccccc2)cc1	10.1021/jm00036a008
		CHEMBL32329	116570	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Reduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heartReduction of dissociation rate of [3H]N-methylscopolamine ([3H]NMS) from muscarinic acetylcholine receptor M2 of pig heart	ChEMBL	399	8	0	2	5.5	Clc1cccc(Cl)c1CO/N=C/c1cc[n+](CCCc2ccccc2)cc1	10.1021/jm00036a008
		102070733	127619	0	None	-	0	Pig	7.0	pEC50	=	7.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3337857	127619	0	None	-	0	Pig	7.0	pEC50	=	7.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		CHEMBL3558415	127619	0	None	-	0	Pig	7.0	pEC50	=	7.0	Binding	Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation countingDisplacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting	ChEMBL	614	2	2	4	4.4	C[N+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N+]8(C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	10.1021/np500259j
		44340802	68905	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	500	15	0	4	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)CCC1=O	10.1021/jm021077w
		CHEMBL177732	68905	0	None	-	0	Pig	5.0	pEC50	=	5.0	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	500	15	0	4	2.9	C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN1C(=O)CCC1=O	10.1021/jm021077w
		11331580	208915	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	726	23	0	6	7.8	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCc1ccccc1)CCCN1C(=O)c2ccccc2C1=O)CCCc1ccccc1	10.1021/jm021077w
		CHEMBL609125	208915	0	None	-	0	Pig	6.0	pEC50	=	6	Binding	Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heartAbility to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart	ChEMBL	726	23	0	6	7.8	O=C1c2ccccc2C(=O)N1CCCN(CCCCCCN(CCCc1ccccc1)CCCN1C(=O)c2ccccc2C1=O)CCCc1ccccc1	10.1021/jm021077w
		367	10596	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		5487427	10596	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		8592	10596	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		CHEMBL1900528	10596	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		CHEMBL3305968	10596	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		CHEMBL4650755	10596	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		DB01409	10596	12	None	-2	8	Human	10.5	pIC50	=	10.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2010.10.016
		367	10596	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		5487427	10596	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		8592	10596	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		CHEMBL1900528	10596	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		CHEMBL3305968	10596	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		CHEMBL4650755	10596	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		DB01409	10596	12	None	-2	8	Human	10.2	pIC50	=	10.2	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2011.10.002
		11434515	7049	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		11519741	7049	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		4484	7049	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		7449	7049	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		CHEMBL1194325	7049	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		DB08897	7049	6	None	-6	5	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmcl.2010.10.016
		10143956	20683	0	None	1	3	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL1196359	20683	0	None	1	3	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL556635	20683	0	None	1	3	Human	9.9	pIC50	=	9.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		11693	8608	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		3494	8608	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		4302	8608	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		7459	8608	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		CHEMBL1201335	8608	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		DB00986	8608	16	None	-2	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrsDisplacement of [3H]NMS from recombinant human M2 receptor expressed in CHO-K1 cells after 16 hrs	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2011.10.002
		11434515	7049	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		11519741	7049	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		4484	7049	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		7449	7049	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		CHEMBL1194325	7049	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		DB08897	7049	6	None	-6	5	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		44233403	20673	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL1196247	20673	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL556222	20673	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		44233401	20396	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
		CHEMBL1194321	20396	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
		CHEMBL551327	20396	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	9	1	6	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1	10.1021/jm900132z
		11852298	20798	0	None	-1	3	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1197251	20798	0	None	-1	3	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL564057	20798	0	None	-1	3	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		155566290	183359	0	None	25	5	Human	9.7	pIC50	=	9.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	183359	0	None	25	5	Human	9.7	pIC50	=	9.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	183359	0	None	25	5	Human	9.7	pIC50	=	9.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		367	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		5487427	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		8592	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		CHEMBL1900528	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		CHEMBL3305968	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		CHEMBL4650755	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		DB01409	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2015.02.065
		367	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		5487427	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		8592	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL1900528	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL3305968	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL4650755	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		DB01409	10596	12	None	-2	8	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		44232930	203472	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL564747	203472	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		44232931	203160	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL562642	203160	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		44232927	202116	8	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	349	4	1	6	2.7	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL551729	202116	8	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	349	4	1	6	2.7	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		44236098	202427	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL556426	202427	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	343	4	1	5	2.6	O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		44233177	20672	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL1196246	20672	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL556221	20672	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	484	7	0	4	5.7	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		44232685	20801	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL1197273	20801	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		CHEMBL564765	20801	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	478	9	1	5	4.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1	10.1021/jm900132z
		20735153	20395	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1194314	20395	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL551063	20395	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	9	0	5	5.6	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1021/jm900132z
		11489419	20390	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		CHEMBL1194274	20390	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		CHEMBL549784	20390	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	448	10	1	5	5.2	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		44233173	20792	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL1197216	20792	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL562890	20792	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	486	7	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		44236340	20564	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1195513	20564	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL554725	20564	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	1	5	5.2	O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		688566	202662	24	None	-	3	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		CHEMBL558910	202662	24	None	-	3	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		49800047	21255	1	None	-1	5	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		CHEMBL1201024	21255	1	None	-1	5	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		CHEMBL1201268	21255	1	None	-1	5	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		44232683	20398	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		CHEMBL1194336	20398	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		CHEMBL551731	20398	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	472	9	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm900132z
		44236336	20785	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		CHEMBL1197131	20785	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		CHEMBL560327	20785	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	364	4	1	5	2.8	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2	10.1021/jm900132z
		11693	8608	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		3494	8608	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		4302	8608	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		7459	8608	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		CHEMBL1201335	8608	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		DB00986	8608	16	None	-2	5	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmcl.2010.10.016
		9913341	88933	4	None	-3	5	Human	9.3	pIC50	=	9.3	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL216927	88933	4	None	-3	5	Human	9.3	pIC50	=	9.3	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL553058	88933	4	None	-3	5	Human	9.3	pIC50	=	9.3	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		44236101	20800	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL1197261	20800	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL564515	20800	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	456	5	1	4	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21	10.1021/jm900132z
		44236099	202334	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL554699	202334	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	4	1	5	2.8	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		10007638	127654	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401648	127654	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559195	127654	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	8	2	4	4.4	O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		67548926	127656	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401649	127656	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559201	127656	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	473	8	2	5	4.5	O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		9809330	122777	0	None	-1	5	Human	9.2	pIC50	=	9.2	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
		CHEMBL335542	122777	0	None	-1	5	Human	9.2	pIC50	=	9.2	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
		44232681	20787	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1197156	20787	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL561187	20787	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	482	9	0	5	5.7	CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1	10.1021/jm900132z
		10325942	127657	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401650	127657	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559202	127657	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	8	2	5	3.9	O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		10143954	20391	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL1194286	20391	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL549986	20391	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		44236332	20789	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL1197183	20789	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL561870	20789	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	470	7	1	4	4.5	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		10143718	69908	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779131	69908	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789435	69908	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		44235871	203351	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	1	4	2.5	O=C(O[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL563887	203351	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	1	4	2.5	O=C(O[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		50925542	25949	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289653	25949	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		10165877	69904	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779133	69904	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789396	69904	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	463	8	0	4	5.6	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		11725334	124554	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	4	2	5	2.3	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401641	124554	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	4	2	5	2.3	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		155566290	183359	0	None	25	5	Human	8.8	pIC50	=	8.8	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	183359	0	None	25	5	Human	8.8	pIC50	=	8.8	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	183359	0	None	25	5	Human	8.8	pIC50	=	8.8	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		9928017	69113	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779033	69113	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		11569908	20773	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL1197028	20773	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL559106	20773	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	0	3	5.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		1201549	7384	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	7384	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	7384	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	7384	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	7384	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	7384	24	None	-5	20	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		52942402	25991	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289983	25991	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4cccc(Cl)c4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		44303019	107723	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		CHEMBL294082	107723	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		10229167	69899	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779136	69899	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789385	69899	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	427	9	0	3	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		14590398	108643	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL300660	108643	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14590401	194757	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL49721	194757	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14054136	67133	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	324	4	1	4	2.7	CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL17460	67133	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	324	4	1	4	2.7	CN(C)CCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		13810575	105358	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/jm00401a016
		CHEMBL276771	105358	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/jm00401a016
		14590398	108643	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL300660	108643	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCCCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		14590401	194757	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL49721	194757	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Cl)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		44333541	11524	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	419	4	2	5	3.2	O=C1Nc2cccnc2N(C(=O)CNCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL103785	11524	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	419	4	2	5	3.2	O=C1Nc2cccnc2N(C(=O)CNCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		60691	108328	26	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumInhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellum	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
		CHEMBL29835	108328	26	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellumInhibitory activity against [3H]N-methyl-scopolamine binding to Muscarinic acetylcholine receptor M2 in rat cerebellum	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
		24739387	194936	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	454	4	0	2	5.2	CC(=O)N1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
		CHEMBL498556	194936	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	454	4	0	2	5.2	CC(=O)N1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
		CHEMBL4639128	220801	17	None	-	0	Human	5.0	pIC50	=	5	Binding	Cross screening panelCross screening panel	ChEMBL		None	None	None		COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC[C@H]4CCNC4)cc3c2n1[C@H](C)c1ccccc1	10.6019/CHEMBL4630907
		44275628	18766	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183229	18766	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL285803	18766	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	0	0	3	0.3	Cn1oc2c(c1=O)C[S+](C)CC2	10.1021/jm00402a010
		10354348	105658	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	241	2	0	5	2.4	CSc1nsnc1C1=C(C)CCN(C)C1	10.1021/jm9705216
		CHEMBL279105	105658	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	241	2	0	5	2.4	CSc1nsnc1C1=C(C)CCN(C)C1	10.1021/jm9705216
		67549179	124558	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1016/j.bmcl.2015.02.065
		CHEMBL3401645	124558	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1016/j.bmcl.2015.02.065
		10784004	20159	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1192621	20159	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL543890	20159	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		137630050	167819	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	5.0	pIC50	=	5.0	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		2774	10640	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		5593	10640	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		7319	10640	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		CHEMBL1200604	10640	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		DB00809	10640	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		DB01199	10640	95	None	-1	10	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		1224	8214	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	8214	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	8214	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	8214	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	8214	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	8214	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		100	10577	58	None	-19	54	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	10577	58	None	-19	54	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	10577	58	None	-19	54	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	10577	58	None	-19	54	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	10577	58	None	-19	54	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		124087	8171	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	8171	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	8171	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	8171	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	8171	114	None	-6	15	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		135	9310	43	None	-25	56	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	9310	43	None	-25	56	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	9310	43	None	-25	56	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	9310	43	None	-25	56	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	9310	43	None	-25	56	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		10782321	18896	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
		CHEMBL1184098	18896	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
		CHEMBL332405	18896	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.3	CCCCCc1noc(C2CN(CC)CC=C2c2ccccc2)n1	10.1021/jm980067l
		10080742	213145	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	166	3	0	3	0.9	C=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL87485	213145	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	166	3	0	3	0.9	C=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		2284	9956	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	9956	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	9956	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	9956	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	9956	33	None	-21	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		10594386	18190	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180249	18190	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL118553	18190	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	4.9	CCN1CC=C(c2ccccc2)C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		2230	7253	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		296	7253	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		CHEMBL7303	7253	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		DB04365	7253	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		9946632	69123	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	354	4	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccc(F)cc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779043	69123	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	354	4	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccc(F)cc1	10.1016/j.bmcl.2011.03.096
		44302901	107833	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	320	1	1	3	3.9	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)cc34)OC21	10.1016/s0960-894x(98)00351-5
		CHEMBL294726	107833	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	320	1	1	3	3.9	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)cc34)OC21	10.1016/s0960-894x(98)00351-5
		6726	8063	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	8063	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	8063	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	8063	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	8063	51	None	-9	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		2683	109665	25	None	-5	16	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	109665	25	None	-5	16	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	109665	25	None	-5	16	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		10547222	121564	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.7	CCCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333940	121564	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.7	CCCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		44236338	20682	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1196358	20682	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL556634	20682	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	6	1	5	4.4	O=C(O[C@H]1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		52948443	25965	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	419	4	0	5	3.9	CCc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289758	25965	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	419	4	0	5	3.9	CCc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		2551	7581	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		298	7581	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		488	7581	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		CHEMBL965	7581	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		DB00411	7581	23	None	-6	11	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		3652	10869	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		57	10869	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		60809	10869	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		CHEMBL21536	10869	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		DB15357	10869	79	None	-18	18	Human	7.9	pIC50	=	7.9	Binding	Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cellsInhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		14590397	194476	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL49525	194476	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14054141	169263	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
		CHEMBL416723	169263	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
		9815331	209886	1	None	1	8	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	209886	1	None	1	8	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		14590397	194476	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL49525	194476	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	5	1	5	3.1	CCN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		9815331	209886	1	None	-1	8	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	209886	1	None	-1	8	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		11793999	18887	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184074	18887	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL331516	18887	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		18456768	69909	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779134	69909	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789445	69909	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	407	8	0	2	5.3	CCCCN(C(=O)O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		2200	9905	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		328	9905	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		4848	9905	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		CHEMBL9967	9905	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		DB00670	9905	46	None	-31	13	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00401a016
		13271739	105302	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	1	2	4	2.6	CN1CCC(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL276282	105302	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	1	2	4	2.6	CN1CCC(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		14054138	105602	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	365	3	1	5	2.0	CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL278701	105602	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	365	3	1	5	2.0	CN1CCN(CCC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		53853235	85456	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	401	2	0	5	3.6	O=C1c2ccccc2-n2c(nc3cccnc32)CN1C[C@@H]1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
		CHEMBL2112432	85456	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	401	2	0	5	3.6	O=C1c2ccccc2-n2c(nc3cccnc32)CN1C[C@@H]1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
		10829928	19174	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
		CHEMBL1185758	19174	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
		CHEMBL431688	19174	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	325	7	0	4	4.4	CCCCCc1noc(C2=C(c3ccccc3)CCN(CC)C2)n1	10.1021/jm980067l
		15730	77893	80	None	-2	10	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	77893	80	None	-2	10	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		10827157	18209	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		CHEMBL1180317	18209	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		CHEMBL121552	18209	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.2	CCN1CC=C(c2ccccc2)C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		52947552	25879	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	404	4	1	5	2.9	O=C(c1ccc(CO)o1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289201	25879	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	404	4	1	5	2.9	O=C(c1ccc(CO)o1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52943921	25896	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	386	3	0	5	2.6	O=C(c1ncccn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289315	25896	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	386	3	0	5	2.6	O=C(c1ncccn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52942610	26099	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	384	3	0	3	3.8	O=C(c1ccccc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290635	26099	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	384	3	0	3	3.8	O=C(c1ccccc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		46891076	13480	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	344	4	2	2	3.8	O=C(NCC1=CCNCC1)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		CHEMBL1083618	13480	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	344	4	2	2	3.8	O=C(NCC1=CCNCC1)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		441383	27105	57	None	-7	17	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	27105	57	None	-7	17	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		9944783	69117	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	316	6	0	3	3.9	CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779037	69117	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	316	6	0	3	3.9	CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		2551	7581	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	7581	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	7581	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	7581	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	7581	23	None	-3	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		2551	7581	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	7581	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	7581	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	7581	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	7581	23	None	-6	11	Human	6.9	pIC50	=	6.9	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		10567372	18903	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1160977	18903	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184119	18903	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333065	18903	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		44302788	207401	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	2	1	5	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL59939	207401	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	2	1	5	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		122203596	162585	0	None	1	5	Human	5.9	pIC50	=	5.9	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	5.9	pIC50	=	5.9	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	5.9	pIC50	=	5.9	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 15 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		10760249	18195	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
		CHEMBL1180285	18195	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
		CHEMBL120119	18195	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm301774u
		10760249	18195	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		CHEMBL1180285	18195	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		CHEMBL120119	18195	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		67547950	127655	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3401655	127655	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3559199	127655	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	456	6	0	3	4.9	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCn3cccc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		54586723	69118	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	3	0	3	3.1	CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779038	69118	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	3	0	3	3.1	CC(C)N(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10686494	107314	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
		CHEMBL291351	107314	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	311	3	0	5	2.7	CN1CCC=C(c2nsnc2OCC#Cc2ccccc2)C1	10.1021/jm9910019
		10393952	69903	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779140	69903	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789389	69903	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	529	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		9798900	69910	1	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
		CHEMBL1779047	69910	1	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
		CHEMBL1789446	69910	1	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmcl.2011.03.096
		107867	9748	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		309	9748	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		CHEMBL17045	9748	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		13578548	108139	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL296988	108139	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		107867	9748	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		309	9748	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		CHEMBL17045	9748	55	None	-14	11	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		13578548	108139	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL296988	108139	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	4	1	5	2.7	CN(C)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		67548544	127660	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3401656	127660	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3559205	127660	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	559	8	0	3	7.1	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1C[N+]2(CCCOc3ccc(-c4ccccc4)cc3)CCC1CC2	10.1016/j.bmcl.2015.02.065
		3088389	29886	3	None	-	0	Mouse	5.9	pIC50	=	5.9	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	368	11	0	6	4.2	CN(C)Cc1ccc(CSCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL13308	29886	3	None	-	0	Mouse	5.9	pIC50	=	5.9	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	368	11	0	6	4.2	CN(C)Cc1ccc(CSCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		2551	7581	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		298	7581	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		488	7581	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		CHEMBL965	7581	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		DB00411	7581	23	None	-6	11	Human	5.9	pIC50	=	5.9	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9702903
		2247	7293	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	7293	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	7293	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	7293	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	7293	81	None	-32	42	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		44303294	207935	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL60331	207935	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	377	3	0	5	3.3	Fc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		4735	201894	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL361506	201894	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL55	201894	96	None	-9	10	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		11057	182928	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	182928	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	182928	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	182928	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		2812	11551	101	None	-33	34	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	11551	101	None	-33	34	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		10518821	18899	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184108	18899	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		CHEMBL332645	18899	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.6	CCN1CC=C(c2ccccc2)C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		44302793	206508	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	350	2	1	4	3.9	COc1cc2c(cc1OC)C1Oc3ccc4[nH]c(C)cc4c3CN1CC2	10.1016/s0960-894x(98)00351-5
		CHEMBL59347	206508	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	350	2	1	4	3.9	COc1cc2c(cc1OC)C1Oc3ccc4[nH]c(C)cc4c3CN1CC2	10.1016/s0960-894x(98)00351-5
		10664532	18884	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184064	18884	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL330892	18884	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		52945272	25980	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	399	4	0	5	3.8	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289866	25980	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	399	4	0	5	3.8	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		52943721	26061	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	354	3	0	3	4.3	O=C(c1ccsc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290410	26061	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	354	3	0	3	4.3	O=C(c1ccsc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		379653	108460	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL299344	108460	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		13578572	193678	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL48980	193678	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14054140	105716	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	364	2	1	4	3.4	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL279528	105716	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	364	2	1	4	3.4	CN1CCCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		5487543	212425	4	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
		CHEMBL81878	212425	4	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm9910019
		24750278	96199	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	450	6	1	9	1.7	CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C	10.1021/acs.jmedchem.6b00475
		CHEMBL237067	96199	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	450	6	1	9	1.7	CC(C)=CCn1c(N2CCC[C@H](N)C2)nc2c1c(=O)n(CC(=O)c1ccccc1)c(=O)n2C	10.1021/acs.jmedchem.6b00475
		379653	108460	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL299344	108460	2	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	499	6	1	5	4.3	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(Br)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		13578572	193678	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL48980	193678	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	6	1	5	3.1	CCN(CC)CC1CCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		14590400	184241	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL46390	184241	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		3071772	105196	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	382	12	0	6	4.6	CN(C)Cc1ccc(CSCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL275537	105196	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	382	12	0	6	4.6	CN(C)Cc1ccc(CSCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		14590400	184241	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL46390	184241	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCCN(CCC)CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		10638050	18187	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL116601	18187	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180202	18187	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.8	CCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		10848032	212872	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1ccsc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL85645	212872	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1ccsc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		44342270	16702	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		CHEMBL114484	16702	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		3652	10869	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		57	10869	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		60809	10869	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		CHEMBL21536	10869	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		DB15357	10869	79	None	-	18	Rat	7.8	pIC50	=	7.8	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm9910019
		44303286	208097	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
		CHEMBL60419	208097	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	309	3	0	5	1.8	C(#Cc1ccccc1)COc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
		3071780	25562	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	520	13	0	6	7.5	CN(C)Cc1ccc(CSCc2ccc(-c3ccc(CSCc4ccc(CN(C)C)o4)cc3)cc2)o1	10.1021/jm00084a015
		CHEMBL12781	25562	3	None	-	0	Mouse	5.8	pIC50	=	5.8	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	520	13	0	6	7.5	CN(C)Cc1ccc(CSCc2ccc(-c3ccc(CSCc4ccc(CN(C)C)o4)cc3)cc2)o1	10.1021/jm00084a015
		44275648	18756	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183077	18756	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL278618	18756	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		13621567	104936	7	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		CHEMBL27384	104936	7	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		CHEMBL440085	104936	7	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		10757736	21276	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL120135	21276	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		10567372	18903	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1160977	18903	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184119	18903	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333065	18903	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		10567372	18903	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1160977	18903	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184119	18903	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333065	18903	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		44302834	209489	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	454	4	1	5	5.9	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Oc4ccccc4)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL61700	209489	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	454	4	1	5	5.9	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Oc4ccccc4)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		4098	39279	30	None	-15	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	39279	30	None	-15	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	39279	30	None	-15	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		10516408	18213	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180330	18213	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL122353	18213	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.0	CCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		10240891	212877	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL85678	212877	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	140	1	0	3	0.3	CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		44303424	207266	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	376	3	0	4	4.6	Clc1cc(Cl)cc(C#CCOc2nsnc2C23CC4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL59862	207266	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	376	3	0	4	4.6	Clc1cc(Cl)cc(C#CCOc2nsnc2C23CC4CC2C3C4)c1	10.1021/jm9910019
		9815331	209886	1	None	1	8	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	209886	1	None	1	8	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		9815331	209886	1	None	-1	8	Human	7.8	pIC50	=	7.8	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	209886	1	None	-1	8	Human	7.8	pIC50	=	7.8	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		324	8706	15	None	-1	9	Human	7.8	pIC50	=	7.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
		6436265	8706	15	None	-1	9	Human	7.8	pIC50	=	7.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
		CHEMBL277642	8706	15	None	-1	9	Human	7.8	pIC50	=	7.8	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(98)00351-5
		10300661	69911	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779135	69911	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789451	69911	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	421	9	0	2	5.7	CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		13578571	107901	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00128a008
		CHEMBL295214	107901	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00128a008
		13578571	107901	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00048a014
		CHEMBL295214	107901	1	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00048a014
		10610375	18194	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
		CHEMBL1180284	18194	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
		CHEMBL120109	18194	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm980067l
		10610375	18194	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
		CHEMBL1180284	18194	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
		CHEMBL120109	18194	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	245	3	0	3	2.3	CCN1CCC(c2ccccc2)=C(C(=O)OC)C1	10.1021/jm301774u
		11820032	105000	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
		CHEMBL274329	105000	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	197	2	0	2	-0.1	C[N+](C)(C)CC#CCN1OCCC1=O	10.1016/S0960-894X(97)00150-9
		3013846	195018	2	None	-4	5	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
		CHEMBL499519	195018	2	None	-4	5	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
		2745	10633	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		5572	10633	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		66007	10633	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		7315	10633	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		CHEMBL1490	10633	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		DB00376	10633	42	None	-46	9	Human	7.7	pIC50	=	7.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	10.1016/s0960-894x(98)00351-5
		306	10229	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		3536	10229	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		53930639	10229	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		9577995	10229	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		CHEMBL134641	10229	21	None	-8	5	Human	6.8	pIC50	=	6.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1021/jm9702903
		2230	7253	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
		296	7253	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
		CHEMBL7303	7253	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
		DB04365	7253	60	None	-75	10	Human	5.8	pIC50	=	5.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9702903
		44275626	17937	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1178434	17937	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL28033	17937	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		163388532	197137	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin)Inhibition of muscarinic M2 receptor (unknown origin)	ChEMBL	681	8	2	9	6.2	Cc1c(C#Cc2ccc(CN3CCC(CO)CC3)cc2)cc(C(F)F)c2cn(C(C(=O)Nc3nccs3)c3ncn4c3CCC43CC3)nc12	10.1021/acs.jmedchem.2c00893
		CHEMBL5177023	197137	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin)Inhibition of muscarinic M2 receptor (unknown origin)	ChEMBL	681	8	2	9	6.2	Cc1c(C#Cc2ccc(CN3CCC(CO)CC3)cc2)cc(C(F)F)c2cn(C(C(=O)Nc3nccs3)c3ncn4c3CCC43CC3)nc12	10.1021/acs.jmedchem.2c00893
		CHEMBL4800073	220833	5	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Selectivity interaction (PSP Principial panel 20118+ (panel of GPCRs, transporter, and ion channels)) EUB0000283b CHRM2Selectivity interaction (PSP Principial panel 20118+ (panel of GPCRs, transporter, and ion channels)) EUB0000283b CHRM2	ChEMBL		None	None	None		C[C@H]1CCCN1Cc1nc2cc(NC(=O)c3ccc4cnccc4c3)ccc2[nH]1	10.6019/CHEMBL5212743
		44356367	125270	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	266	3	0	2	2.2	C[N+](C)(C)CC#CCOC(=O)c1cccc(Cl)c1	10.1021/jm9702903
		CHEMBL341447	125270	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	266	3	0	2	2.2	C[N+](C)(C)CC#CCOC(=O)c1cccc(Cl)c1	10.1021/jm9702903
		122203596	162585	0	None	1	5	Human	6.7	pIC50	=	6.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	6.7	pIC50	=	6.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	6.7	pIC50	=	6.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		137630050	167819	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	4.7	pIC50	=	4.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		10684720	18866	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1183926	18866	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL324712	18866	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.5	CCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		2551	7581	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		298	7581	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		488	7581	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		CHEMBL965	7581	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		DB00411	7581	23	None	-3	11	Rat	4.7	pIC50	=	4.7	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/S0960-894X(01)80787-3
		19816	64359	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	153	3	0	2	0.9	CC(=O)CCC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		CHEMBL166736	64359	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	153	3	0	2	0.9	CC(=O)CCC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		52946249	25860	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	390	3	0	4	3.9	O=C(c1cccs1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289082	25860	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	390	3	0	4	3.9	O=C(c1cccs1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		10420458	213047	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL86903	213047	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		71454411	85224	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL2111621	85224	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		44302741	209434	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL61412	209434	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		4011	89183	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	89183	49	None	-35	24	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		10521205	18201	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180298	18201	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL120599	18201	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.5	CCN1CC=C(c2ccccc2)C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		9903030	69122	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	4	0	3	4.2	Cc1ccc(N(Cc2ccccc2)C(=O)O[C@H]2CN3CCC2CC3)cc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779042	69122	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	4	0	3	4.2	Cc1ccc(N(Cc2ccccc2)C(=O)O[C@H]2CN3CCC2CC3)cc1	10.1016/j.bmcl.2011.03.096
		46871844	13584	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	360	4	2	2	4.1	C[C@H]1CNCC[C@@H]1CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		CHEMBL1083925	13584	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	360	4	2	2	4.1	C[C@H]1CNCC[C@@H]1CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		46871665	13367	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	346	4	2	2	3.9	O=C(NCC1CCNCC1)c1ccccc1-c1cc(Cl)ccc1F	10.1016/j.bmcl.2010.04.128
		CHEMBL1083108	13367	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	346	4	2	2	3.9	O=C(NCC1CCNCC1)c1ccccc1-c1cc(Cl)ccc1F	10.1016/j.bmcl.2010.04.128
		1273	8535	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		3450	8535	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		356	8535	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		6172	8535	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		67425	8535	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		CHEMBL360055	8535	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		DB00483	8535	16	None	-1	3	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		25897919	62426	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
		657309	62426	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
		CHEMBL1464005	62426	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
		CHEMBL1621597	62426	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2015.02.065
		44236334	20784	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL1197117	20784	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL559931	20784	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	468	7	0	3	5.6	CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21	10.1021/jm900132z
		44233175	20791	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL1197209	20791	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		CHEMBL562655	20791	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	440	5	1	3	4.3	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21	10.1021/jm900132z
		25897919	62426	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		657309	62426	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		CHEMBL1464005	62426	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		CHEMBL1621597	62426	14	None	-1	8	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		52947320	26020	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	362	3	0	2	4.5	Cc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2)CC3)c1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290184	26020	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	362	3	0	2	4.5	Cc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2)CC3)c1	10.1016/j.bmcl.2010.10.016
		939077	201847	2	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		CHEMBL549577	201847	2	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm900132z
		44303323	170021	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		CHEMBL418491	170021	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		10785471	120493	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.9	CCCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL332320	120493	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	371	12	0	3	5.9	CCCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		14590403	195174	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00128a008
		CHEMBL50176	195174	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00128a008
		13810574	66468	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	310	3	1	4	2.3	CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL17228	66468	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	310	3	1	4	2.3	CN(C)CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		14590403	195174	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00048a014
		CHEMBL50176	195174	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	7	1	5	4.1	CCc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCCCC1CN(CC)CC	10.1021/jm00048a014
		302	9751	25	None	-4	8	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		4630	9751	25	None	-4	8	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		CHEMBL7634	9751	25	None	-4	8	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		24739886	194648	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	469	6	1	3	4.2	NC(=O)CN1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
		CHEMBL496376	194648	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	469	6	1	3	4.2	NC(=O)CN1CCCC(c2ccccc2)(C2CCN(Cc3ccc(Br)cc3)CC2)C1	10.1016/j.bmcl.2008.07.115
		14590396	179321	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL44838	179321	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14590396	179321	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL44838	179321	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.9	CCN(CC)CC1CCCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		19716	16039	6	None	-	1	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	2	0	2	0.6	CC(=O)N(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		CHEMBL11081	16039	6	None	-	1	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	2	0	2	0.6	CC(=O)N(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		10356006	212428	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		CHEMBL81895	212428	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		10515352	112952	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL313749	112952	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		122203596	162585	0	None	1	5	Human	5.7	pIC50	=	5.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	5.7	pIC50	=	5.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	5.7	pIC50	=	5.7	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 30 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		10019339	109403	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL304247	109403	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	327	3	0	5	1.9	Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		1935	10506	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		2551	10506	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		6687	10506	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		CHEMBL95	10506	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		DB00382	10506	97	None	-	6	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		1935	10506	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		2551	10506	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		6687	10506	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		CHEMBL95	10506	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		DB00382	10506	97	None	-6	6	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00084a015
		2750	210840	76	None	-4	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	210840	76	None	-4	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		5282593	62032	26	None	-5	5	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		CHEMBL1319362	62032	26	None	-5	5	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		CHEMBL1618018	62032	26	None	-5	5	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		10808719	18904	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184120	18904	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL333125	18904	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		10399393	212565	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL83074	212565	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.1	C#CCC#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		4212	205458	82	None	1	4	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		CHEMBL1417019	205458	82	None	1	4	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		CHEMBL58	205458	82	None	1	4	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		154734599	9281	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
		327	9281	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
		4108	9281	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
		CHEMBL27673	9281	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.11.014
		154734599	9281	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
		327	9281	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
		4108	9281	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
		CHEMBL27673	9281	12	None	1	12	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2016.03.006
		10546275	21974	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.5	CCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL121059	21974	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.5	CCCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		10133281	69120	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	5	0	5	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779040	69120	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	5	0	5	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
		9857572	69116	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	302	5	0	3	3.5	CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779036	69116	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	302	5	0	3	3.5	CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		13578549	108051	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL296317	108051	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		10678449	29425	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	154	2	0	3	0.6	CO/N=C/[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		CHEMBL132698	29425	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	154	2	0	3	0.6	CO/N=C/[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		13578549	108051	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL296317	108051	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CC1CCCCN1CCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		10846833	56579	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	225	0	0	5	1.7	CN1CCC2=C(C1)c1nsnc1SC2	10.1021/jm9705216
		CHEMBL15675	56579	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	225	0	0	5	1.7	CN1CCC2=C(C1)c1nsnc1SC2	10.1021/jm9705216
		3071773	26180	3	None	-	0	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	396	13	0	6	4.9	CN(C)Cc1ccc(CSCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL12937	26180	3	None	-	0	Mouse	5.7	pIC50	=	5.7	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	396	13	0	6	4.9	CN(C)Cc1ccc(CSCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		44275683	106058	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL281944	106058	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL541666	106058	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		10593954	19848	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1190178	19848	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL540316	19848	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	7	0	3	4.2	CCN1CC=C(c2ccccc2)C(C(=O)OCCCc2ccccc2)C1	10.1021/jm980067l
		10358345	18214	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1180331	18214	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL122354	18214	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.3	CCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		9996901	124555	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	4	1	4	3.2	O=C(N[C@H]1CN2CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401642	124555	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	332	4	1	4	3.2	O=C(N[C@H]1CN2CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		3236	74383	43	None	1	2	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
		CHEMBL1902981	74383	43	None	1	2	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
		10641009	18198	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180292	18198	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL120472	18198	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	341	6	0	3	4.7	CCN1CCC(c2ccccc2)=C(C(=O)OCCC2CCCCC2)C1	10.1021/jm980067l
		10726038	126210	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.6	CO/N=C(\C#N)C12CCN(CC1)C2	10.1021/jm9702903
		CHEMBL344892	126210	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.6	CO/N=C(\C#N)C12CCN(CC1)C2	10.1021/jm9702903
		44333603	116424	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	5	1	3	4.8	Cc1cc(C(=O)c2ccccc2)ccc1NC(=O)CC1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
		CHEMBL322378	116424	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	5	1	3	4.8	Cc1cc(C(=O)c2ccccc2)ccc1NC(=O)CC1CCCN2CCCC[C@H]12	10.1016/s0960-894x(99)00528-4
		3072503	11638	6	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	353	9	1	6	3.7	CN(C)Cc1ccc(CSCCNc2ccc(F)cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL104355	11638	6	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	353	9	1	6	3.7	CN(C)Cc1ccc(CSCCNc2ccc(F)cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		3072518	12018	4	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccn3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL106344	12018	4	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccn3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		2398	7741	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	7741	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	7741	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	7741	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	7741	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		10663572	19931	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1190784	19931	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL541584	19931	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		44303396	208015	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		CHEMBL60374	208015	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		9974222	18693	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1182709	18693	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL262198	18693	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	335	6	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		10778750	170737	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		CHEMBL420781	170737	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		52942628	25859	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccco1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289081	25859	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccco1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52942401	25990	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289982	25990	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		44275767	104393	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL27096	104393	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL540136	104393	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		52945255	26079	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	350	3	0	4	3.0	O=C(c1ncccn1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290520	26079	1	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	350	3	0	4	3.0	O=C(c1ncccn1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		46891179	13189	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	378	4	2	2	4.2	C[C@H]1CNCC[C@]1(F)CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		CHEMBL1082365	13189	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	378	4	2	2	4.2	C[C@H]1CNCC[C@]1(F)CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.127
		118728611	124557	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401644	124557	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
		10267601	18901	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1184116	18901	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL332980	18901	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		44302775	209575	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OCC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL62247	209575	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	4	1	5	4.5	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OCC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		10573693	18202	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		CHEMBL1180305	18202	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		CHEMBL120963	18202	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.5	CCN1CCC(c2ccccc2)=C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		3158	63041	27	None	-630	20	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	63041	27	None	-630	20	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		10220392	212784	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL84893	212784	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	240	2	0	3	1.7	C(#Cc1ccccc1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		4841	74201	5	None	-1	5	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		CHEMBL1889399	74201	5	None	-1	5	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		CHEMBL1909073	74201	5	None	-1	5	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		44303314	107710	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL293982	107710	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.6	Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		54585743	69124	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	372	4	0	3	4.2	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccc(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779044	69124	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	372	4	0	3	4.2	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccc(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		44275682	18763	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183197	18763	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL284208	18763	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		191	7191	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	7191	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	7191	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	7191	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	7191	98	None	-56	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		3823	56995	42	None	-44	11	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	56995	42	None	-44	11	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	56995	42	None	-44	11	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		44302900	209577	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	3	1	5	4.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OC(C)C)c34)OC21	10.1016/s0960-894x(98)00351-5
		CHEMBL62251	209577	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	406	3	1	5	4.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OC(C)C)c34)OC21	10.1016/s0960-894x(98)00351-5
		44302813	108707	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	362	2	1	4	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL301041	108707	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	362	2	1	4	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
		137630050	167819	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	5.6	pIC50	=	5.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 0.4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		2028	9753	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		359	9753	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		4634	9753	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		CHEMBL1231	9753	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		DB01062	9753	80	None	-8	11	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		44303327	169790	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
		CHEMBL417560	169790	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	325	3	0	5	2.5	C(#Cc1ccccc1)CSc1nsnc1C12CN3CC1C2C3	10.1021/jm9910019
		10539130	113507	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		CHEMBL314420	113507	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		10567192	18868	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1183934	18868	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL324936	18868	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	313	4	0	3	3.9	CCN1CC=C(c2ccccc2)C(C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		10567372	18903	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1160977	18903	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184119	18903	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL333065	18903	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	8	0	3	4.1	CCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		10777692	18199	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180296	18199	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL120539	18199	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.6	CCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		68617	212306	62	None	-32	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	212306	62	None	-32	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	212306	62	None	-32	26	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		54585742	69111	1	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779031	69111	1	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		54582845	69905	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779139	69905	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789405	69905	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	525	8	0	3	6.2	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		10451242	209893	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL64029	209893	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.8	Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		10262466	105120	0	None	-	5	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		CHEMBL275104	105120	0	None	-	5	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/S0960-894X(97)00150-9
		122203596	162585	0	None	1	5	Human	6.6	pIC50	=	6.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	6.6	pIC50	=	6.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	6.6	pIC50	=	6.6	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 4 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		10538337	18883	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
		CHEMBL1184062	18883	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
		CHEMBL330885	18883	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	245	3	0	3	2.2	CCN1CC=C(c2ccccc2)C(C(=O)OC)C1	10.1021/jm980067l
		67547652	124560	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	2	0	3	3.5	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.02.065
		CHEMBL3401647	124560	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	348	2	0	3	3.5	CN(C(=O)C1c2ccccc2Oc2ccccc21)[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2015.02.065
		154734599	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
		327	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
		4108	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
		CHEMBL27673	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm701575k
		11678378	127664	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		CHEMBL3401654	127664	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		CHEMBL3559211	127664	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	469	7	1	3	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		54586745	69914	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779138	69914	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789461	69914	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	523	8	0	2	6.8	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		134688371	21201	10	None	-	1	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		13765	21201	10	None	-	1	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		CHEMBL1200623	21201	10	None	-	1	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		3652	53018	70	None	-2	9	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
		CHEMBL1535	53018	70	None	-2	9	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
		50925541	25931	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289545	25931	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		50925543	25950	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289654	25950	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	405	3	0	5	3.6	Cc1nc(C(=O)N2CCOC3(CCN(Cc4ccccc4Cl)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		10119939	69902	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1777827	69902	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789388	69902	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		155522355	183188	0	None	31	5	Human	8.5	pIC50	=	8.5	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	183188	0	None	31	5	Human	8.5	pIC50	=	8.5	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	183188	0	None	31	5	Human	8.5	pIC50	=	8.5	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		9967590	68915	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	336	4	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1777826	68915	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	336	4	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		174174	7311	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		260	7311	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		320	7311	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		CHEMBL517712	7311	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		DB00572	7311	49	None	-7	14	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		2551	7581	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		298	7581	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		488	7581	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		CHEMBL965	7581	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		DB00411	7581	23	None	-6	11	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/s0960-894x(98)00351-5
		10208972	69906	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779129	69906	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789429	69906	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	457	8	0	3	5.5	O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		52942458	26019	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	382	3	0	2	4.9	O=C(c1ccccc1)N1CCC2(CCN(Cc3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290183	26019	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	382	3	0	2	4.9	O=C(c1ccccc1)N1CCC2(CCN(Cc3cccc(Cl)c3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		10094518	108170	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL297224	108170	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		10096508	183802	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00128a008
		CHEMBL46315	183802	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00128a008
		11725107	107389	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL291872	107389	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	345	3	0	5	2.1	Fc1cc(F)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		10094518	108170	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL297224	108170	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2ccc(C)cc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		10096508	183802	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00048a014
		CHEMBL46315	183802	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	475	5	1	5	4.8	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCCC1	10.1021/jm00048a014
		3072508	114265	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	522	15	2	11	3.6	CN(C)Cc1ccc(CSCCNc2cc(NCCCN3CCOCC3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL318517	114265	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	522	15	2	11	3.6	CN(C)Cc1ccc(CSCCNc2cc(NCCCN3CCOCC3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		14054145	105404	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL277078	105404	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	351	2	1	5	1.6	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL5076569	221228	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2cccnc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
		44302727	108695	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccc(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL300987	108695	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccc(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		10176679	140387	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	209	3	0	4	0.8	CCN1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		CHEMBL37132	140387	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	209	3	0	4	0.8	CCN1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		10797864	32917	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	1.0	CO/N=C(\C#N)C12CCCN(CC1)C2	10.1021/jm9702903
		CHEMBL135645	32917	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidinyl benzilate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	193	2	0	4	1.0	CO/N=C(\C#N)C12CCCN(CC1)C2	10.1021/jm9702903
		52947254	25979	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289865	25979	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	433	4	0	5	4.4	CC(C)c1nc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)cs1	10.1016/j.bmcl.2010.10.016
		52949961	26120	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	424	3	0	4	4.6	O=C(c1ccc2occc2c1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290752	26120	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	424	3	0	4	4.6	O=C(c1ccc2occc2c1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		3072505	115349	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	409	11	2	9	3.5	CNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		CHEMBL320291	115349	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	409	11	2	9	3.5	CNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		2551	7581	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	7581	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	7581	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	7581	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	7581	23	None	-3	11	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		2551	7581	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	7581	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	7581	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	7581	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	7581	23	None	-6	11	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		2274	9947	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	9947	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	9947	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	9947	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	9947	58	None	-100	31	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		3652	10869	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		57	10869	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		60809	10869	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		CHEMBL21536	10869	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		DB15357	10869	79	None	-18	18	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 60 mins by scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		24882193	195428	0	None	-	2	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		CHEMBL503468	195428	0	None	-	2	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	770	14	4	4	10.4	O=C(Nc1ccc2[nH]cc(C3CCN(CCCCCCCN4CCC(c5c[nH]c6ccc(NC(=O)c7ccc(F)cc7)cc56)CC4)CC3)c2c1)c1ccc(F)cc1	10.1021/jm7011722
		3198	212292	76	None	-16	34	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	212292	76	None	-16	34	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	212292	76	None	-16	34	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		54586743	69915	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
		CHEMBL1779130	69915	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
		CHEMBL1789462	69915	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	357	4	0	3	4.1	C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2	10.1016/j.bmcl.2011.03.096
		13578551	108061	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL296405	108061	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		13578551	108061	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL296405	108061	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	7	1	5	3.9	CCN(CC)CCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		9882189	174213	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic 2 receptor (unknown origin)Binding affinity to muscarinic 2 receptor (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1016/j.bmc.2022.117032
		CHEMBL4297224	174213	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic 2 receptor (unknown origin)Binding affinity to muscarinic 2 receptor (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1016/j.bmc.2022.117032
		9882189	174213	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01192
		CHEMBL4297224	174213	33	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	281	4	0	2	3.5	CN(C)CC1CCOC1(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01192
		3072510	12137	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	485	13	2	9	5.1	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL106936	12137	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	485	13	2	9	5.1	CN(C)Cc1ccc(CSCCNc2cc(NCc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		10761219	18203	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1180309	18203	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL121298	18203	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	363	8	0	3	4.6	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCc2ccccc2)C1	10.1021/jm980067l
		2337	10030	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	10030	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	10030	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	10030	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	10030	77	None	-31	62	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		2745	10633	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		5572	10633	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		66007	10633	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		7315	10633	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		CHEMBL1490	10633	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		DB00376	10633	42	None	-46	9	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		2551	7581	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		298	7581	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		488	7581	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		CHEMBL965	7581	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		DB00411	7581	23	None	-3	11	Rat	7.5	pIC50	=	7.5	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9910019
		154734599	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
		327	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
		4108	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
		CHEMBL27673	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2010.07.034
		154734599	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
		327	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
		4108	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
		CHEMBL27673	9281	12	None	1	12	Human	7.5	pIC50	=	7.5	Binding	Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uMPercent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm058018d
		24996645	77201	0	None	-	2	Human	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	416	5	0	6	4.0	Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(C3CCC3)CC2)cc1	10.1016/j.bmcl.2011.11.118
		CHEMBL1945848	77201	0	None	-	2	Human	6.5	pIC50	=	6.5	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	416	5	0	6	4.0	Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(C3CCC3)CC2)cc1	10.1016/j.bmcl.2011.11.118
		44275767	104393	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL27096	104393	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL540136	104393	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	173	1	0	2	0.7	COC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		290	9251	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		4022	9251	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		5926	9251	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		CHEMBL40554	9251	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		CHEMBL74300	9251	6	None	-12	7	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/S0960-894X(00)80535-1
		15685990	64857	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	3	1	3	1.0	CC(/C=N/O)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		CHEMBL167335	64857	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	3	1	3	1.0	CC(/C=N/O)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		11498	9793	41	None	-67	6	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
		4995951	9793	41	None	-67	6	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
		CHEMBL59898	9793	41	None	-67	6	Human	5.5	pIC50	=	5.5	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/s0960-894x(98)00351-5
		1971	9641	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	9641	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	9641	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	9641	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	9641	38	None	-9	30	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		11695697	124559	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	1	3	3.1	O=C(N[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		CHEMBL3401646	124559	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	2	1	3	3.1	O=C(N[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1016/j.bmcl.2015.02.065
		54583839	69115	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	4	0	3	3.1	CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779035	69115	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	288	4	0	3	3.1	CCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		277	8083	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	8083	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	8083	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	8083	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	8083	62	None	-12	50	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2286	9957	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	9957	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	9957	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	9957	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	9957	51	None	-3	30	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		118728610	124553	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	336	4	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401640	124553	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	336	4	2	3	2.1	O=C(N[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2015.02.065
		3067217	68072	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	356	2	1	5	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cscc32)CC1	10.1021/jm00401a016
		CHEMBL17671	68072	3	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	356	2	1	5	2.2	CN1CCN(CC(=O)N2c3ccccc3NC(=O)c3cscc32)CC1	10.1021/jm00401a016
		3072506	12096	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	437	13	2	9	4.3	CCCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		CHEMBL106782	12096	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	437	13	2	9	4.3	CCCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		3072512	12135	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	450	12	2	10	4.3	CC(C)=NNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		CHEMBL106932	12135	3	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	450	12	2	10	4.3	CC(C)=NNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		10639739	18421	2	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
		CHEMBL1181055	18421	2	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
		CHEMBL154087	18421	2	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	208	1	0	2	2.5	CN1CCC=C(c2ccc(Cl)nc2)C1	10.1016/s0960-894x(99)00575-2
		6918276	22383	7	None	-131	8	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	22383	7	None	-131	8	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		10759393	91160	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL2112589	91160	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL2219563	91160	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		25014630	90314	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
		CHEMBL2203713	90314	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	326	3	3	4	3.3	N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1	10.1016/j.ejmech.2012.07.006
		44275648	18756	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183077	18756	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL278618	18756	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	186	1	0	3	1.0	COc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		1548953	214458	27	None	-6	17	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	214458	27	None	-6	17	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		154734599	9281	12	None	1	12	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		327	9281	12	None	1	12	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		4108	9281	12	None	1	12	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		CHEMBL27673	9281	12	None	1	12	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		3072515	11966	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	496	12	2	10	5.1	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3C#N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL106082	11966	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	496	12	2	10	5.1	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3C#N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		202718	94099	22	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Antagonist activity at rat muscarinic M2 receptor isolated from brainAntagonist activity at rat muscarinic M2 receptor isolated from brain	ChEMBL	277	4	0	1	4.6	C(CN1CCCCC1)=C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2012.12.054
		CHEMBL2332280	94099	22	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Antagonist activity at rat muscarinic M2 receptor isolated from brainAntagonist activity at rat muscarinic M2 receptor isolated from brain	ChEMBL	277	4	0	1	4.6	C(CN1CCCCC1)=C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2012.12.054
		4601	213526	35	None	-2	17	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	213526	35	None	-2	17	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	213526	35	None	-2	17	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		3072507	12021	2	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	466	14	2	10	3.5	CN(C)CCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		CHEMBL106348	12021	2	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	466	14	2	10	3.5	CN(C)CCNc1cc(NCCSCc2ccc(CN(C)C)o2)c([N+](=O)[O-])cc1[N+](=O)[O-]	10.1021/jm00095a008
		1726	9275	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	9275	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	9275	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	9275	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	9275	13	None	-3	5	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1726	9275	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	9275	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	9275	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	9275	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	9275	13	None	-2	5	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		13621567	104936	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		CHEMBL27384	104936	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		CHEMBL440085	104936	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	168	1	0	4	0.7	COc1noc2c1CN(C)CC2	10.1021/jm00402a010
		10595006	18217	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL1180343	18217	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL123099	18217	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Binding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assayBinding affinity to human M2 muscarinic receptor expressed in cell membranes by radioligand binding assay	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		10595006	18217	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		CHEMBL1180343	18217	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		CHEMBL123099	18217	0	None	-6	5	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		10777343	212948	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	254	2	0	3	2.1	Cc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		CHEMBL86288	212948	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	254	2	0	3	2.1	Cc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		52946359	25895	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	3	0	6	2.7	O=C(c1cnsn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289314	25895	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	3	0	6	2.7	O=C(c1cnsn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		44275683	106058	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL281944	106058	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		CHEMBL541666	106058	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	187	2	0	2	1.1	CCOC(=O)C1=CCC[S+](C)C1	10.1021/jm00402a010
		9308	24526	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	24526	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	24526	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	24526	21	None	-2	7	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		9308	24526	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	24526	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	24526	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	24526	21	None	2	7	Human	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		10611310	18895	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1184096	18895	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL332335	18895	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	259	4	0	3	2.7	CCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		316	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		46890977	13504	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	Cc1ccc(-c2ccccc2C(=O)NCC2CCNCC2)cc1Cl	10.1016/j.bmcl.2010.04.128
		CHEMBL1083723	13504	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	Cc1ccc(-c2ccccc2C(=O)NCC2CCNCC2)cc1Cl	10.1016/j.bmcl.2010.04.128
		46871666	13841	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	CC1CNCCC1CNC(=O)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
		CHEMBL1084993	13841	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	342	4	2	2	4.0	CC1CNCCC1CNC(=O)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
		10208897	69901	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779049	69901	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789387	69901	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	455	8	0	2	6.1	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10246307	124556	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	4	2	4	2.3	O=C(N[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401643	124556	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	334	4	2	4	2.3	O=C(N[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1016/j.bmcl.2015.02.065
		316	9611	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		317	9611	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		71183	9611	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		CHEMBL3140030	9611	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		CHEMBL376897	9611	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		DB00462	9611	19	None	-6	9	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cellCompound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfected chinese hamster ovarian cell	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/s0960-894x(98)00351-5
		11306852	20797	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
		CHEMBL1197250	20797	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
		CHEMBL563996	20797	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	434	8	1	3	5.0	CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2	10.1021/jm900132z
		11539632	77336	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		CHEMBL194837	77336	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		9946010	69114	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779034	69114	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	342	4	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10053614	127658	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401651	127658	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559203	127658	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	483	9	2	5	4.2	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		14075467	108257	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL297818	108257	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14075467	108257	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL297818	108257	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	455	6	1	5	4.2	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(Cl)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		107867	9748	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		309	9748	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		CHEMBL17045	9748	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		302	9751	25	None	-34	8	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
		4630	9751	25	None	-34	8	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
		CHEMBL7634	9751	25	None	-34	8	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9705216
		3071778	170064	3	None	-	0	Mouse	6.4	pIC50	=	6.4	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	466	18	0	6	6.9	CN(C)Cc1ccc(CSCCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL418712	170064	3	None	-	0	Mouse	6.4	pIC50	=	6.4	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	466	18	0	6	6.9	CN(C)Cc1ccc(CSCCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		3072509	12344	3	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3cccnc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107673	12344	3	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	486	13	2	10	4.5	CN(C)Cc1ccc(CSCCNc2cc(NCc3cccnc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		107867	9748	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		309	9748	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		CHEMBL17045	9748	55	None	-14	11	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		10333583	212829	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL85264	212829	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	274	2	0	3	2.4	Clc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10686988	18961	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
		CHEMBL1184244	18961	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
		CHEMBL340780	18961	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	317	8	0	3	4.2	CCCCCCOC(=O)[C@H]1CN(CC)CC[C@H]1c1ccccc1	10.1021/jm980067l
		155522355	183188	0	None	31	5	Human	7.4	pIC50	=	7.4	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	183188	0	None	31	5	Human	7.4	pIC50	=	7.4	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	183188	0	None	31	5	Human	7.4	pIC50	=	7.4	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		10852843	18696	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1182713	18696	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL262303	18696	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	315	4	0	3	4.0	CCN1CC[C@@H](c2ccccc2)[C@H](C(=O)OC2CCCCC2)C1	10.1021/jm980067l
		44304805	209801	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
		CHEMBL345233	209801	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
		CHEMBL63325	209801	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentrationInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat heart atria at 10e-5 M of compound concentration	ChEMBL	234	1	0	2	3.0	CN1C2C=C(c3ccc(Cl)nc3)CC1CC2	10.1016/s0960-894x(99)00575-2
		10132599	69112	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	5	0	3	4.0	O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779032	69112	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	350	5	0	3	4.0	O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10755733	18200	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		CHEMBL1180297	18200	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		CHEMBL120581	18200	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	5	0	3	3.4	CCN1CCC(c2ccccc2)=C(C(=O)OCC(C)C)C1	10.1021/jm980067l
		4189	213701	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	213701	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	213701	96	None	-18	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		316	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	9611	19	None	-6	9	Human	6.4	pIC50	=	6.4	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 0.1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		44275682	18763	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1183197	18763	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL284208	18763	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	210	2	0	3	1.0	C#CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		3072514	12191	3	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	489	12	2	9	5.4	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccc(F)cc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107254	12191	3	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	489	12	2	9	5.4	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccc(F)cc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		19718	211603	7	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	2	0	2	0.0	CC(=O)N(C)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		CHEMBL75358	211603	7	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	168	2	0	2	0.0	CC(=O)N(C)CC#CCN(C)C	10.1016/S0960-894X(00)80535-1
		9308	24526	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	24526	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	24526	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	24526	21	None	2	7	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		10688349	18908	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184138	18908	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL334194	18908	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	337	6	0	3	3.9	CCN1CC[C@@H](c2ccccc2)[C@@H](C(=O)OCCc2ccccc2)C1	10.1021/jm980067l
		54583840	69125	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	404	4	0	3	4.7	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2CN3CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779045	69125	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	404	4	0	3	4.7	Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2CN3CCC2CC3)c1	10.1016/j.bmcl.2011.03.096
		10591874	20088	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1192001	20088	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL543177	20088	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	321	5	0	3	3.9	CCN1CCC(c2ccccc2)=C(C(=O)OCc2ccccc2)C1	10.1021/jm980067l
		2230	7253	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
		296	7253	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
		CHEMBL7303	7253	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
		DB04365	7253	60	None	-75	10	Human	5.4	pIC50	=	5.4	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705216
		11811722	16837	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
		CHEMBL115280	16837	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	413	5	1	4	4.4	O=C1NCN(c2ccccc2)C12CCN(Cc1cccc(Oc3ccccc3)c1)CC2	10.1021/jm010878g
		5310989	207656	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	3	1	5	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL60142	207656	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	378	3	1	5	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		3042	8196	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		355	8196	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		868	8196	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		CHEMBL1123	8196	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		DB00804	8196	35	None	-28	15	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		44275680	17935	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1178406	17935	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL26932	17935	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneCompound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		10660	21188	58	None	-4	12	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	21188	58	None	-4	12	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		10826990	212935	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	285	3	0	5	1.7	O=[N+]([O-])c1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		CHEMBL86197	212935	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	285	3	0	5	1.7	O=[N+]([O-])c1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		44302879	209497	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	348	1	1	4	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL61774	209497	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	348	1	1	4	3.7	COC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2ccccc2C1O3	10.1016/s0960-894x(98)00351-5
		10522202	18206	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180312	18206	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL121385	18206	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	355	7	0	3	5.1	CCN1CCC(c2ccccc2)=C(C(=O)OCCCC2CCCCC2)C1	10.1021/jm980067l
		44303018	208802	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL60833	208802	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		3055247	25703	6	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	478	14	2	8	3.2	CN(C)Cc1ccc(CSCCNC(=NC#N)NCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL12858	25703	6	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	478	14	2	8	3.2	CN(C)Cc1ccc(CSCCNC(=NC#N)NCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		10755732	18893	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1184092	18893	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL332181	18893	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	287	6	0	3	3.4	CCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		5747382	115980	3	None	-	1	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL321605	115980	3	None	-	1	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		10549581	18221	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		CHEMBL1180349	18221	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		CHEMBL123198	18221	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	411	7	0	3	5.4	CCN1CC=C(c2ccccc2)C(C(=O)OCC(c2ccccc2)c2ccccc2)C1	10.1021/jm980067l
		135398737	7745	93	None	-22	90	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	7745	93	None	-22	90	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	7745	93	None	-22	90	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	7745	93	None	-22	90	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	7745	93	None	-22	90	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		167962	10841	4	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	10841	4	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	10841	4	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		10563152	212849	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		CHEMBL85460	212849	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	258	2	0	3	1.9	Fc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		72548703	168346	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		CHEMBL4128926	168346	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]AF-DX 384 from human recombinant M2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		10082470	59491	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
		CHEMBL15944	59491	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
		CHEMBL308608	59491	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	227	2	0	5	2.0	CSc1nsnc1C1=CCCN(C)C1	10.1021/jm9705216
		9804849	74230	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
		CHEMBL189118	74230	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against muscarinic acetylcholine receptor M2Inhibitory concentration against muscarinic acetylcholine receptor M2	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
		44275626	17937	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1178434	17937	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL28033	17937	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	214	2	0	3	1.8	CC(C)Oc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		10522336	21902	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.3	CCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL120972	21902	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	357	11	0	3	5.3	CCCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		44303397	109065	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL303360	109065	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	359	3	0	5	3.1	Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		9308	24526	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	24526	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	24526	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	24526	21	None	-2	7	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		44275680	17935	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL1178406	17935	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		CHEMBL26932	17935	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	200	2	0	3	1.4	CCOc1noc2c1C[S+](C)CC2	10.1021/jm00402a010
		107867	9748	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		309	9748	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		CHEMBL17045	9748	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00128a008
		14054139	168546	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	336	2	1	4	2.7	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
		CHEMBL413966	168546	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	336	2	1	4	2.7	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)C1	10.1021/jm00401a016
		107867	9748	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		309	9748	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		CHEMBL17045	9748	55	None	-14	11	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00048a014
		52950036	25930	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	391	3	0	5	3.3	O=C(c1cscn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289544	25930	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	391	3	0	5	3.3	O=C(c1cscn1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52943879	26121	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	388	3	0	4	3.7	Cc1ccc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)o1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290753	26121	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	388	3	0	4	3.7	Cc1ccc(C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2)o1	10.1016/j.bmcl.2010.10.016
		11569926	69907	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779048	69907	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789434	69907	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	441	7	0	2	5.7	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		14054137	105661	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	338	5	1	4	3.0	CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL279135	105661	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	338	5	1	4	3.0	CN(C)CCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		44268378	28723	0	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	497	17	2	10	3.4	CN(C)Cc1ccc(CSCCN/C=C(/NCCSCc2ccc(CN(C)C)o2)[N+](=O)[O-])o1	10.1021/jm00084a015
		CHEMBL13206	28723	0	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	497	17	2	10	3.4	CN(C)Cc1ccc(CSCCN/C=C(/NCCSCc2ccc(CN(C)C)o2)[N+](=O)[O-])o1	10.1021/jm00084a015
		14590394	187665	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL47575	187665	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14590394	187665	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL47575	187665	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	407	4	1	4	4.1	CCN(CC)CC1CCCCN1C(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		316	9611	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	9611	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	9611	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	9611	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	9611	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	9611	19	None	-6	9	Human	6.3	pIC50	=	6.3	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 2 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		176	7186	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	7186	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	7186	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	7186	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	7186	66	None	-2	31	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		154734599	9281	12	None	1	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		327	9281	12	None	1	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		4108	9281	12	None	1	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		CHEMBL27673	9281	12	None	1	12	Human	7.3	pIC50	=	7.3	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		10937901	16682	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
		CHEMBL114379	16682	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	385	3	1	6	4.0	Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1	10.1021/jm010878g
		10058347	112708	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL312823	112708	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	190	3	0	3	0.9	C#C/C=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10035533	212482	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2	ChEMBL	194	3	0	3	1.7	CC(C)=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL82378	212482	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2Binding affinity of compound labeled by [3H]QNB in CHO cells selectively expressing human Muscarinic acetylcholine receptor M2	ChEMBL	194	3	0	3	1.7	CC(C)=CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10854880	18193	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1180282	18193	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL120080	18193	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	5.1	CCCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		3071774	28320	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	410	14	0	6	5.3	CN(C)Cc1ccc(CSCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL13166	28320	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	410	14	0	6	5.3	CN(C)Cc1ccc(CSCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		1726	9275	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	9275	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	9275	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	9275	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	9275	13	None	-3	5	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTPInhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1726	9275	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	9275	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	9275	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	9275	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	9275	13	None	-2	5	Human	5.3	pIC50	=	5.3	Binding	Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTPInhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		5487543	212425	4	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		CHEMBL81878	212425	4	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1	10.1021/jm960683m
		43815	193699	64	None	-15	25	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		CHEMBL1708	193699	64	None	-15	25	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		CHEMBL490	193699	64	None	-15	25	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		3071777	170065	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	452	17	0	6	6.5	CN(C)Cc1ccc(CSCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL418714	170065	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	452	17	0	6	6.5	CN(C)Cc1ccc(CSCCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		10636001	18197	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1180290	18197	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL120329	18197	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	273	5	0	3	3.1	CCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		5648	85186	9	None	-2	5	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		CHEMBL2107687	85186	9	None	-2	5	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		CHEMBL2111176	85186	9	None	-2	5	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		1734	6904	10	None	-9	13	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		307	6904	10	None	-9	13	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		CHEMBL168067	6904	10	None	-9	13	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		3071779	23594	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	444	12	0	6	5.9	CN(C)Cc1ccc(CSCc2ccc(CSCc3ccc(CN(C)C)o3)cc2)o1	10.1021/jm00084a015
		CHEMBL12472	23594	3	None	-	0	Mouse	6.3	pIC50	=	6.3	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	444	12	0	6	5.9	CN(C)Cc1ccc(CSCc2ccc(CSCc3ccc(CN(C)C)o3)cc2)o1	10.1021/jm00084a015
		15685982	63300	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	3	1	3	1.6	CC(/C=N/O)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		CHEMBL163661	63300	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	194	3	1	3	1.6	CC(/C=N/O)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		13578552	166956	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00128a008
		CHEMBL410928	166956	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00128a008
		13578552	166956	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00048a014
		CHEMBL410928	166956	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	419	4	1	5	3.3	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCC2)c2ccccc21	10.1021/jm00048a014
		9905467	18208	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1180316	18208	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL121520	18208	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.3	CCN1CCC(c2ccccc2)=C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		6075	156887	42	None	-7	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	156887	42	None	-7	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		3072501	114046	6	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL316973	114046	6	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		154059	10409	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		2457	10409	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		7483	10409	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		CHEMBL1734	10409	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		DB01591	10409	51	None	-12	8	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		2335	18620	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	18620	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	18620	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	18620	22	None	-2	12	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		3071775	103991	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	424	15	0	6	5.7	CN(C)Cc1ccc(CSCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL268499	103991	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	424	15	0	6	5.7	CN(C)Cc1ccc(CSCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		3071771	27866	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	592	18	2	12	5.5	CN(C)Cc1ccc(CSCCNc2cc(NCCSCc3ccc(CN(C)C)o3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00084a015
		CHEMBL13122	27866	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	592	18	2	12	5.5	CN(C)Cc1ccc(CSCCNc2cc(NCCSCc3ccc(CN(C)C)o3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00084a015
		2230	7253	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		296	7253	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		CHEMBL7303	7253	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		DB04365	7253	60	None	-107	10	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm00402a010
		44575653	188423	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	327	14	7	4	0.4	N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N	10.1021/np50120a004
		CHEMBL477542	188423	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	327	14	7	4	0.4	N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N	10.1021/np50120a004
		52943696	26037	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	348	3	0	2	4.2	O=C(c1ccccc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290294	26037	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	348	3	0	2	4.2	O=C(c1ccccc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		14374296	108430	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL299142	108430	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		13578554	179204	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00128a008
		CHEMBL44773	179204	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00128a008
		14374296	108430	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL299142	108430	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	449	8	1	5	4.3	CCN(CC)CCCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		13578554	179204	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00048a014
		CHEMBL44773	179204	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	461	5	1	5	4.4	CN(CC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C1CCCCC1	10.1021/jm00048a014
		6410685	116033	3	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	337	9	1	8	2.4	CN(C)Cc1ccc(CSCCNc2nnccc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL321808	116033	3	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	337	9	1	8	2.4	CN(C)Cc1ccc(CSCCNc2nnccc2[N+](=O)[O-])o1	10.1021/jm00095a008
		13578555	183459	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00128a008
		CHEMBL45983	183459	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity of compound for cardiac Muscarinic acetylcholine receptor M2 in rat using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00128a008
		14590399	108055	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL296365	108055	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14054144	67207	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	337	0	1	4	2.2	CN1CCN(C(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL17519	67207	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	337	0	1	4	2.2	CN1CCN(C(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		14590399	108055	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL296365	108055	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	393	5	2	5	2.8	CCNCC1CCCCN1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		13578555	183459	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00048a014
		CHEMBL45983	183459	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	433	4	1	5	3.7	O=C1Nc2cccnc2N(C(=O)CN2CCCCC2CN2CCCCC2)c2ccccc21	10.1021/jm00048a014
		10851853	18960	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1184242	18960	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL340561	18960	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	301	7	0	3	3.9	CCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		71450872	85454	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL2112418	85454	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2cccnc2N(C(=O)C[C@@H]2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		10058744	213161	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL87622	213161	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	204	3	0	3	1.3	C#C/C(C)=C/CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10397133	113839	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL315676	113839	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	164	2	0	3	0.3	C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		10487582	35002	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		CHEMBL137384	35002	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		24180125	102431	71	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
		CHEMBL257991	102431	71	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	469	5	2	8	3.7	O=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1	10.1021/jm8012954
		44303017	207612	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		CHEMBL60101	207612	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	343	3	0	5	2.4	Clc1ccc(C#CCOc2nsnc2C23CN4CC2C3C4)cc1	10.1021/jm9910019
		52947553	25880	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccoc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289202	25880	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	374	3	0	4	3.4	O=C(c1ccoc1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		122203596	162585	0	None	1	5	Human	6.2	pIC50	=	6.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	6.2	pIC50	=	6.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	6.2	pIC50	=	6.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as W84 pIC50 at 8 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		3072513	13034	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	471	12	2	9	5.2	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL108163	13034	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	471	12	2	9	5.2	CN(C)Cc1ccc(CSCCNc2cc(Nc3ccccc3)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		78319901	166013	35	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
		CHEMBL4098877	166013	35	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a CHRM2	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
		118728611	124557	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401644	124557	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	294	4	2	4	1.6	CCC(O)(C(=O)N[C@H]1CN2CCC1CC2)c1cccs1	10.1016/j.bmcl.2015.02.065
		60691	108328	26	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PInhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
		CHEMBL29835	108328	26	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PInhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)P	ChEMBL	251	4	0	3	3.7	CCCN(c1ccncc1)n1ccc2ccccc21	10.1021/jm9506433
		15685977	127121	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	193	3	0	2	1.7	CC(=O)C(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		CHEMBL353023	127121	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	193	3	0	2	1.7	CC(=O)C(C)CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		2726	7706	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	7706	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	7706	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	7706	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	7706	68	None	-79	72	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		137630050	167819	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	5.2	pIC50	=	5.2	Binding	Competitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assayCompetitive binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenates assessed as W84 pIC50 at 1 nM after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		10499832	18907	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184134	18907	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		CHEMBL334093	18907	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	377	9	0	3	5.0	CCN1CC=C(c2ccccc2)C(C(=O)OCCCCCc2ccccc2)C1	10.1021/jm980067l
		10782462	18886	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL1184068	18886	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		CHEMBL330999	18886	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	327	5	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCC2CCCCC2)C1	10.1021/jm980067l
		14660293	59427	3	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	191	0	1	4	1.3	c1cc2nsnc2c2c1CCNC2	10.1021/jm9705216
		CHEMBL15936	59427	3	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2	ChEMBL	191	0	1	4	1.3	c1cc2nsnc2c2c1CCNC2	10.1021/jm9705216
		3072504	12584	7	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107892	12584	7	None	-	1	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamineBinding affinity against rat muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		44333819	11485	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2ccccc2N(C(=O)CC2CCCN3CCCCC23)c2ncccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL103529	11485	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	390	2	1	4	4.0	O=C1Nc2ccccc2N(C(=O)CC2CCCN3CCCCC23)c2ncccc21	10.1016/s0960-894x(99)00528-4
		2200	9905	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		328	9905	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		4848	9905	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		CHEMBL9967	9905	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		DB00670	9905	46	None	-31	13	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/s0960-894x(99)00528-4
		10707175	212930	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL86150	212930	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccccc1C#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		1210	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	7705	51	None	-257	21	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		10187216	69912	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779128	69912	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789452	69912	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	461	8	0	3	6.1	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		14590402	107864	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		CHEMBL294919	107864	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00128a008
		14590402	107864	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		CHEMBL294919	107864	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	435	6	1	5	3.8	CCN(CC)CC1CCCCN1CC(=O)N1c2cc(C)ccc2C(=O)Nc2cccnc21	10.1021/jm00048a014
		13269694	66222	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL17120	66222	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.0	CN1CCC(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		14054135	68292	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	296	2	1	4	1.9	CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL17709	68292	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	296	2	1	4	1.9	CN(C)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		10511551	32603	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		CHEMBL135328	32603	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	ChEMBL	179	2	0	4	0.5	CO/N=C(\C#N)[C@@H]1CN2CC[C@H]1C2	10.1021/jm9702903
		3072502	11698	13	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	398	10	1	8	3.6	CN(C)Cc1ccc(CSCCNc2cc(F)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL104681	11698	13	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissueInhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue	ChEMBL	398	10	1	8	3.6	CN(C)Cc1ccc(CSCCNc2cc(F)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		24871823	99304	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic 2 receptor (unknown origin)Inhibition of muscarinic 2 receptor (unknown origin)	ChEMBL	355	3	0	7	3.2	C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12	10.1021/jm400926x
		CHEMBL2431819	99304	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of muscarinic 2 receptor (unknown origin)Inhibition of muscarinic 2 receptor (unknown origin)	ChEMBL	355	3	0	7	3.2	C[C@@H](c1ccc2ncccc2c1)c1nnc2ccc(-c3cnn(C)c3)nn12	10.1021/jm400926x
		3071776	31321	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	438	16	0	6	6.1	CN(C)Cc1ccc(CSCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		CHEMBL13426	31321	3	None	-	0	Mouse	6.2	pIC50	=	6.2	Binding	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortexCompound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to muscarinic acetylcholine receptor M2 of mouse cerebral cortex	ChEMBL	438	16	0	6	6.1	CN(C)Cc1ccc(CSCCCCCCCSCc2ccc(CN(C)C)o2)o1	10.1021/jm00084a015
		10806268	18909	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL1184139	18909	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		CHEMBL334245	18909	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.7	CCCCCCCOC(=O)C1=C(c2ccccc2)CCN(CC)C1	10.1021/jm980067l
		15181802	18937	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
		CHEMBL1184199	18937	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
		CHEMBL338611	18937	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	471	7	0	7	3.4	Cn1c(=O)c2c(ncn2CCCN2CCC(C(c3ccccc3)c3ccccc3)CC2)n(C)c1=O	10.1021/jm00020a018
		10666533	18204	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		CHEMBL1180310	18204	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		CHEMBL121299	18204	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	365	7	0	4	3.8	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm980067l
		14058518	17934	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		CHEMBL1178388	17934	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		CHEMBL25649	17934	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		10592484	18207	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180314	18207	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL121476	18207	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	329	9	0	3	4.5	CCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		1212	8443	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	8443	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	8443	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	8443	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	8443	50	None	-1380	65	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		11256587	9240	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
		8580	9240	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
		CHEMBL518924	9240	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
		DB05501	9240	59	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	349	7	2	4	3.6	NCCCCN([C@H]1CCCc2c1nccc2)Cc1nc2c([nH]1)cccc2	10.1021/acs.jmedchem.1c01564
		9966959	69121	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	6	0	4	3.6	CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		CHEMBL1779041	69121	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	322	6	0	4	3.6	CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmcl.2011.03.096
		44333822	11437	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	406	2	1	4	4.8	O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL103189	11437	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	406	2	1	4	4.8	O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		10048670	114235	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	436	4	1	5	4.3	O=C1Nc2cccnc2N(C(=O)CSCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		CHEMBL318316	114235	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.Displacement of [3H]methylscopolamine binding to muscarinic M2 receptor in rat heart.	ChEMBL	436	4	1	5	4.3	O=C1Nc2cccnc2N(C(=O)CSCC2CCCN3CCCCC23)c2ccccc21	10.1016/s0960-894x(99)00528-4
		57345320	10604	9	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		9882	10604	9	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		CHEMBL3091687	10604	9	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL	364	7	2	4	3.2	NCCCCN([C@H]1CCCc2c1nccc2)C[C@@H]1NCc2c(C1)cccc2	10.1021/acs.jmedchem.1c01564
		3055	8215	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		313	8215	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		7163	8215	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		CHEMBL936	8215	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		DB01231	8215	44	None	-2	9	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		44302755	209455	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	408	4	1	6	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL61494	209455	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	408	4	1	6	3.8	CCOC(=O)c1c[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		10854879	18189	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL1180239	18189	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		CHEMBL118241	18189	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	343	10	0	3	4.9	CCCCCCCCOC(=O)C1CN(CC)CC=C1c1ccccc1	10.1021/jm980067l
		1273	8535	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		3450	8535	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		356	8535	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		6172	8535	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		67425	8535	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		CHEMBL360055	8535	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		DB00483	8535	16	None	-1	3	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		1016	10519	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	10519	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	10519	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	10519	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	10519	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	10519	78	None	-23	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		3191	109635	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	109635	97	None	-8	25	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		44303293	208205	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL60479	208205	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	393	3	0	5	3.8	Clc1cc(Cl)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		44235638	202093	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	347	2	0	3	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2CCc2ccccc21	10.1021/jm900132z
		CHEMBL551525	202093	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cells by microplate scintillation counting	ChEMBL	347	2	0	3	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2CCc2ccccc21	10.1021/jm900132z
		52945165	25913	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	375	3	0	5	2.8	O=C(c1ccon1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		CHEMBL1289432	25913	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	375	3	0	5	2.8	O=C(c1ccon1)N1CCOC2(CCN(Cc3ccc(Cl)cc3)CC2)C1	10.1016/j.bmcl.2010.10.016
		52942497	26038	3	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	349	3	0	3	3.6	O=C(c1cccnc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290295	26038	3	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	349	3	0	3	3.6	O=C(c1cccnc1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		3233138	26060	2	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	338	3	0	3	3.8	O=C(c1ccco1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290409	26060	2	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	338	3	0	3	3.8	O=C(c1ccco1)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		52949883	26098	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	5	0	3	4.6	CCOc1ccccc1C(=O)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290634	26098	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	392	5	0	3	4.6	CCOc1ccccc1C(=O)N1CCC2(CCN(Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2010.10.016
		57396813	78320	0	None	-	5	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
		CHEMBL1949930	78320	0	None	-	5	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
		CHEMBL1963007	78320	0	None	-	5	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 receptorInhibition of M2 receptor	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
		10085070	212763	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL84726	212763	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	280	3	0	3	2.7	C/C(C#Cc1ccccc1)=C\CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		52946068	26005	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	413	4	0	5	4.1	Cc1ccccc1CN1CCC2(CC1)CN(C(=O)c1csc(C(C)C)n1)CCO2	10.1016/j.bmcl.2010.10.016
		CHEMBL1290077	26005	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	413	4	0	5	4.1	Cc1ccccc1CN1CCC2(CC1)CN(C(=O)c1csc(C(C)C)n1)CCO2	10.1016/j.bmcl.2010.10.016
		52947416	26078	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	341	2	0	3	3.2	O=C(N1CCC2(CCN(Cc3ccccc3)CC2)CC1)N1CC=CO1	10.1016/j.bmcl.2010.10.016
		CHEMBL1290519	26078	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assayDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 16 hrs by scintillation proximity assay	ChEMBL	341	2	0	3	3.2	O=C(N1CCC2(CCN(Cc3ccccc3)CC2)CC1)N1CC=CO1	10.1016/j.bmcl.2010.10.016
		46891488	13945	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	328	4	2	2	3.7	O=C(NCC1CCNCC1)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
		CHEMBL1085507	13945	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human muscarinic M2 receptor expressed in CHO cellsInhibition of human muscarinic M2 receptor expressed in CHO cells	ChEMBL	328	4	2	2	3.7	O=C(NCC1CCNCC1)c1ccccc1-c1cccc(Cl)c1	10.1016/j.bmcl.2010.04.128
		14054142	66292	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.2	CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		CHEMBL17155	66292	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	350	2	1	4	3.2	CN1CCCCC1CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00401a016
		10143858	69913	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779132	69913	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789454	69913	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	467	8	0	4	6.2	O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1	10.1016/j.bmcl.2011.03.096
		10164137	69900	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779137	69900	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		CHEMBL1789386	69900	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	423	9	0	3	5.1	CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1	10.1016/j.bmcl.2011.03.096
		2200	9905	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		328	9905	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		4848	9905	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		CHEMBL9967	9905	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		DB00670	9905	46	None	-31	13	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00128a008
		14590395	108295	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00128a008
		CHEMBL298078	108295	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligandBinding affinity to the rat cardiac muscarinic acetylcholine receptor M2 using 0.3 nM [3H]N-methylscopolamine as radioligand	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00128a008
		14590395	108295	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00048a014
		CHEMBL298078	108295	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of muscarinic (M2) receptor isolated from rat atriaInhibition of muscarinic (M2) receptor isolated from rat atria	ChEMBL	421	6	1	5	3.4	CCN(CC)CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00048a014
		16005860	194185	7	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
		CHEMBL493677	194185	7	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	388	5	1	2	4.8	CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1	10.1021/jm800830n
		67547662	127663	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401653	127663	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559210	127663	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	482	7	2	3	4.2	CN(CCC[N+]12CCC(CC1)[C@@H](NC(=O)C1(O)c3ccccc3-c3ccccc31)C2)c1ccccc1	10.1016/j.bmcl.2015.02.065
		42636350	89368	41	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	367	5	2	4	3.6	Cc1nc(C)c(-c2ccc([C@H]3CC[C@H](CC(=O)O)CC3)cc2)nc1C(N)=O	10.1021/jm301296t
		CHEMBL2178953	89368	41	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	367	5	2	4	3.6	Cc1nc(C)c(-c2ccc([C@H]3CC[C@H](CC(=O)O)CC3)cc2)nc1C(N)=O	10.1021/jm301296t
		9990434	113116	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL313918	113116	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	202	2	0	3	0.7	C#CCC#CCO/N=C1\CN2CCC1C2	10.1021/jm960683m
		180	7189	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	7189	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	7189	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	7189	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	7189	56	None	-27	40	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		1530	8963	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	8963	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	8963	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	8963	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	8963	50	None	-43	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		10778462	212787	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		CHEMBL84919	212787	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	270	3	0	4	1.8	COc1ccc(C#CCO/N=C2\CN3CCC2C3)cc1	10.1021/jm960683m
		302	9751	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		4630	9751	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		CHEMBL7634	9751	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenatesDisplacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(00)80535-1
		302	9751	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
		4630	9751	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
		CHEMBL7634	9751	25	None	-4	8	Rat	6.1	pIC50	=	6.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/S0960-894X(01)80787-3
		44265375	212926	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
		CHEMBL8610	212926	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nMBinding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quinuclidinyl benzylate) radioligand at a concentration of 0.12 nM	ChEMBL	208	2	0	4	0.8	C(#CCN1CCCC1)COC1=NOCC1	10.1016/S0960-894X(97)00150-9
		CHEMBL5070958	221028	3	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of M2 mAChR receptor (unknown origin)Inhibition of M2 mAChR receptor (unknown origin)	ChEMBL		None	None	None		NCCCCN(C[C@H]1Cc2ncccc2CN1)[C@H]1CCCc2cccnc21	10.1021/acs.jmedchem.1c01564
		54584800	69119	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	356	5	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779039	69119	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	356	5	0	4	4.0	O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)Cc1cccs1	10.1016/j.bmcl.2011.03.096
		2166	9897	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		305	9897	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		5910	9897	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		CHEMBL550	9897	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		DB01085	9897	49	None	-4	8	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/S0960-894X(01)80787-3
		10610448	212904	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1cccs1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		CHEMBL85936	212904	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2	ChEMBL	246	2	0	4	1.8	C(#Cc1cccs1)CO/N=C1\CN2CCC1C2	10.1021/jm960683m
		13271741	66306	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	2	5	1.7	CN1CCN(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL17162	66306	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	2	5	1.7	CN1CCN(NC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		13271742	66425	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	1	5	3.0	CN1CCC(OC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		CHEMBL17213	66425	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2	ChEMBL	352	1	1	5	3.0	CN1CCC(OC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00401a016
		10392705	127659	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3401652	127659	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		CHEMBL3559204	127659	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting methodDisplacement of [3H]NMS from human M2 receptor expressed in CHOK1 cell membranes after 4 hrs by scintillation counting method	ChEMBL	467	9	1	4	5.1	O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1	10.1016/j.bmcl.2015.02.065
		2230	7253	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
		296	7253	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
		CHEMBL7303	7253	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
		DB04365	7253	60	None	-107	10	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/S0960-894X(01)80787-3
		44303408	208725	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		CHEMBL60777	208725	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.	ChEMBL	361	3	0	5	2.6	Fc1cc(Cl)cc(C#CCOc2nsnc2C23CN4CC2C3C4)c1	10.1021/jm9910019
		49853884	97458	0	None	-	0	Human	4.0	pIC50	=	4.0	Binding	Binding affinity to M2 receptor (unknown origin) by radioligand displacement assayBinding affinity to M2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	265	3	1	3	1.2	O=C(CN1CCN2CCC[C@H]2C1)NC1CCCCC1	10.1016/j.bmc.2013.02.058
		CHEMBL2391353	97458	0	None	-	0	Human	4.0	pIC50	=	4.0	Binding	Binding affinity to M2 receptor (unknown origin) by radioligand displacement assayBinding affinity to M2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	265	3	1	3	1.2	O=C(CN1CCN2CCC[C@H]2C1)NC1CCCCC1	10.1016/j.bmc.2013.02.058
		44302728	205492	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	422	4	1	6	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL58228	205492	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	422	4	1	6	4.1	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)c(OC)cc2C1O3	10.1016/s0960-894x(98)00351-5
		14058518	17934	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		CHEMBL1178388	17934	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		CHEMBL25649	17934	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartInhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	183	1	0	3	0.8	COc1noc2c1C[N+](C)(C)CC2	10.1021/jm00402a010
		44302776	109127	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	376	2	1	4	4.4	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(C)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		CHEMBL303758	109127	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL	376	2	1	4	4.4	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(C)ccc2C1O3	10.1016/s0960-894x(98)00351-5
		10614695	18929	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		CHEMBL1184188	18929	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		CHEMBL338280	18929	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	307	4	0	3	3.8	CCN1CCC(c2ccccc2)=C(C(=O)Oc2ccccc2)C1	10.1021/jm980067l
		10569816	18231	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		CHEMBL1180367	18231	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		CHEMBL124173	18231	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	349	6	0	3	4.1	CCN1CC=C(c2ccccc2)C(C(=O)OCCc2ccc(C)cc2)C1	10.1021/jm980067l
		10248541	189678	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	369	15	7	4	0.5	CC(=O)NC(CCCNC(=N)N)C(=O)CCCCCCCCNC(=N)N	10.1021/np50120a004
		CHEMBL479224	189678	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of QNB from muscarinic M2 receptorDisplacement of QNB from muscarinic M2 receptor	ChEMBL	369	15	7	4	0.5	CC(=O)NC(CCCNC(=N)N)C(=O)CCCCCCCCNC(=N)N	10.1021/np50120a004
		237	211644	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL546257	211644	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL554190	211644	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL7568	211644	48	None	-1	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		2200	9905	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		328	9905	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		4848	9905	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		CHEMBL9967	9905	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		DB00670	9905	46	None	-35	13	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cellsDisplacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M2 using membranes from transfected CHO cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm980067l
		25147683	69126	37	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	408	4	0	3	4.5	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		CHEMBL1779046	69126	37	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	ChEMBL	408	4	0	3	4.5	O=C(O[C@H]1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1	10.1016/j.bmcl.2011.03.096
		164612037	192156	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	192156	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		168290235	199747	0	None	-6	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	199747	0	None	-6	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	199747	0	None	-6	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168294767	199798	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	199798	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	199798	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168295528	199810	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	199810	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	199810	0	None	-1	20	Human	10.0	pKd	=	10	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic acetylcholine M2 receptor stably expressed in CHO cells by radioligand competition binding based analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		10457079	16802	0	None	-4	2	Human	9.8	pKd	=	9.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL115078	16802	0	None	-4	2	Human	9.8	pKd	=	9.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		688566	202662	24	None	-1	3	Rat	9.7	pKd	=	9.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00020a004
		CHEMBL558910	202662	24	None	-1	3	Rat	9.7	pKd	=	9.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00020a004
		137630050	167819	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		137630050	167819	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	9.7	pKd	=	9.7	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		137630050	167819	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell suspension after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		137630050	167819	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	9.5	pKd	=	9.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		10387775	85267	0	None	-3	2	Rat	9.4	pKd	=	9.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
		CHEMBL2111842	85267	0	None	-3	2	Rat	9.4	pKd	=	9.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
		156015807	185078	0	None	3	5	Human	9.3	pKd	=	9.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	185078	0	None	3	5	Human	9.3	pKd	=	9.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	185078	0	None	3	5	Human	9.3	pKd	=	9.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 180 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		162677523	190453	0	None	-1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4756833	190453	0	None	-1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4802932	190453	0	None	-1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		10387775	85267	0	None	-3	2	Rat	9.2	pKd	=	9.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
		CHEMBL2111842	85267	0	None	-3	2	Rat	9.2	pKd	=	9.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C\I)c1ccccc1	10.1021/jm00020a004
		162649253	190424	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4748004	190424	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4802611	190424	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		156015900	185100	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4643273	185100	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651104	185100	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		156015900	185100	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4643273	185100	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651104	185100	0	None	5	5	Human	9.2	pKd	=	9.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		122203596	162585	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	9.2	pKd	=	9.2	Binding	Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constantRatio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		156015807	185078	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	185078	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	185078	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		122203596	162585	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		122203596	162585	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		4120	12706	6	None	-1	3	Rat	9.1	pKd	=	9.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL107979	12706	6	None	-1	3	Rat	9.1	pKd	=	9.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL293927	12706	6	None	-1	3	Rat	9.1	pKd	=	9.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	318	4	1	4	1.1	C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		156015807	185078	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	185078	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	185078	0	None	3	5	Human	9.1	pKd	=	9.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		137630050	167819	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	9.0	pKd	=	9.0	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		162677523	190453	0	None	-1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4756833	190453	0	None	-1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4802932	190453	0	None	-1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCalibur flow cytometric saturation binding study relative to control	ChEMBL	930	14	2	10	5.8	CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		156014820	185084	0	None	3	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4646116	185084	0	None	3	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4650998	185084	0	None	3	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		156015978	185102	0	None	1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	185102	0	None	1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	185102	0	None	1	5	Human	8.9	pKd	=	8.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 110 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		14753629	20440	0	None	-1	3	Rat	8.8	pKd	=	8.8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL1194660	20440	0	None	-1	3	Rat	8.8	pKd	=	8.8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL553066	20440	0	None	-1	3	Rat	8.8	pKd	=	8.8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	302	5	2	4	1.9	N=CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		10101246	16318	0	None	-81	2	Human	8.8	pKd	=	8.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL112297	16318	0	None	-81	2	Human	8.8	pKd	=	8.8	Binding	Binding of [3H]QNB to HM2 receptor was evaluated by saturation binding assayBinding of [3H]QNB to HM2 receptor was evaluated by saturation binding assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		162654942	190450	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4754371	190450	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802913	190450	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		162649253	190424	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4748004	190424	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4802611	190424	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	807	12	1	6	7.9	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		156016041	185026	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	185026	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	185026	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells at 22 +/- 1 degree C preincubated for 120 mins followed by atropine addition by flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		162645430	190406	0	None	-1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4744233	190406	0	None	-1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802409	190406	0	None	-1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		324	8706	15	None	-1	9	Rat	8.0	pKd	=	8	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
		6436265	8706	15	None	-1	9	Rat	8.0	pKd	=	8	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
		CHEMBL277642	8706	15	None	-1	9	Rat	8.0	pKd	=	8	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/0960-894X(94)00459-S
		14753632	20280	0	None	-2	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL1193564	20280	0	None	-2	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL544993	20280	0	None	-2	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	5	2	5	0.9	N=CN1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		14753634	20499	0	None	-5	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL1195059	20499	0	None	-5	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL553783	20499	0	None	-5	3	Rat	8.0	pKd	=	8	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	316	4	2	4	2.3	CC(=N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		156015153	185086	0	None	1	5	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	185086	0	None	1	5	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	185086	0	None	1	5	Human	8.0	pKd	=	8.0	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		10125445	82803	0	None	-25	5	Human	7.0	pKd	=	7	Binding	Activity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbacholActivity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbachol	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
		CHEMBL205654	82803	0	None	-25	5	Human	7.0	pKd	=	7	Binding	Activity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbacholActivity at muscarinic M2 receptor in guinea pig paced left atrium stimulated with carbachol	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
		71716224	93731	0	None	-1	3	Guinea pig	6.0	pKd	=	6.0	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323444	93731	0	None	-1	3	Guinea pig	6.0	pKd	=	6.0	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		14753624	20508	0	None	-4	3	Rat	8.0	pKd	=	8.0	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL1195123	20508	0	None	-4	3	Rat	8.0	pKd	=	8.0	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL553894	20508	0	None	-4	3	Rat	8.0	pKd	=	8.0	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	317	4	3	4	1.2	N=C(N)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		156016041	185026	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	185026	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	185026	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		156016041	185026	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	185026	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	185026	0	None	1	5	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		15038486	92543	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80325-X
		CHEMBL22923	92543	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80325-X
		15038486	92543	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
		CHEMBL22923	92543	0	None	3	3	Rat	5.9	pKd	=	5.9	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
		71718669	93733	0	None	2	3	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323446	93733	0	None	2	3	Guinea pig	5.9	pKd	=	5.9	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		44457850	105734	0	None	-1	2	Rat	7.8	pKd	=	7.8	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL279712	105734	0	None	-1	2	Rat	7.8	pKd	=	7.8	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		167962	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		167962	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		76315655	112982	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		76315655	112982	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL2261153	112982	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL2261153	112982	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL3138747	112982	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL3138747	112982	0	None	-	1	Guinea pig	5.8	pKd	=	5.8	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		11957991	113223	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		11957991	113223	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL2261155	113223	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL2261155	113223	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL3139843	113223	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL3139843	113223	0	None	-	1	Guinea pig	5.7	pKd	=	5.7	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		167962	10841	4	None	-	1	Human	6.7	pKd	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	10841	4	None	-	1	Human	6.7	pKd	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	10841	4	None	-	1	Human	6.7	pKd	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		162654942	190450	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4754371	190450	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802913	190450	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	833	17	2	7	8.1	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		156015153	185086	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	185086	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	185086	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		156015978	185102	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	185102	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	185102	0	None	1	5	Human	8.7	pKd	=	8.7	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44457838	168660	0	None	2	2	Rat	8.7	pKd	=	8.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL415038	168660	0	None	2	2	Rat	8.7	pKd	=	8.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		156014820	185084	0	None	3	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4646116	185084	0	None	3	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		CHEMBL4650998	185084	0	None	3	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1039/d0md00137f
		162677513	190523	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4789147	190523	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4803695	190523	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		156015153	185086	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	185086	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	185086	0	None	1	5	Human	8.6	pKd	=	8.6	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		174174	7311	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		260	7311	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		320	7311	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		CHEMBL517712	7311	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		DB00572	7311	49	None	-4	14	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00170a010
		5861	18057	11	None	-1	3	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL1179176	18057	11	None	-1	3	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		CHEMBL63452	18057	11	None	-1	3	Rat	8.6	pKd	=	8.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	304	4	1	3	2.1	C[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm00170a010
		156015978	185102	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	185102	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	185102	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44457835	90161	0	None	-11	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCCC1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL21942	90161	0	None	-11	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCCC1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		44457839	90769	0	None	-4	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.2	CN1CCCCC1C/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL22071	90769	0	None	-4	2	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.2	CN1CCCCC1C/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		3636	17919	5	None	1	3	Rat	6.7	pKd	=	6.7	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL1178342	17919	5	None	1	3	Rat	6.7	pKd	=	6.7	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL21823	17919	5	None	1	3	Rat	6.7	pKd	=	6.7	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	360	7	1	4	2.2	CCCC[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		14753627	20478	0	None	-5	3	Rat	7.6	pKd	=	7.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL1194941	20478	0	None	-5	3	Rat	7.6	pKd	=	7.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL553562	20478	0	None	-5	3	Rat	7.6	pKd	=	7.6	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	331	4	3	5	0.2	N=C(N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		44373048	59304	0	None	2	2	Rat	6.6	pKd	=	6.6	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	433	6	0	5	5.0	CC(=O)OC[C@H]1C[C@H]2CCCC[C@@H]2[C@@H](/C=C/[C@H]2CCC[C@H](C)N2C)[C@H]1[C@H](C)OC(C)=O	10.1016/0960-894X(94)00459-S
		CHEMBL159189	59304	0	None	2	2	Rat	6.6	pKd	=	6.6	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	433	6	0	5	5.0	CC(=O)OC[C@H]1C[C@H]2CCCC[C@@H]2[C@@H](/C=C/[C@H]2CCC[C@H](C)N2C)[C@H]1[C@H](C)OC(C)=O	10.1016/0960-894X(94)00459-S
		44457833	101562	0	None	-7	2	Rat	7.6	pKd	=	7.6	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	307	2	0	2	4.3	CN1CCCCC1/C=C/C1c2ccccc2OC2C=CC=CC21	10.1016/S0960-894X(00)80325-X
		CHEMBL25334	101562	0	None	-7	2	Rat	7.6	pKd	=	7.6	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	307	2	0	2	4.3	CN1CCCCC1/C=C/C1c2ccccc2OC2C=CC=CC21	10.1016/S0960-894X(00)80325-X
		167962	10841	4	None	-	1	Human	6.6	pKd	=	6.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	10841	4	None	-	1	Human	6.6	pKd	=	6.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	10841	4	None	-	1	Human	6.6	pKd	=	6.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		76312112	113217	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		76312112	113217	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL2261148	113217	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL2261148	113217	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL3139732	113217	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL3139732	113217	0	None	-	1	Guinea pig	6.6	pKd	=	6.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		76315655	113112	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		76315655	113112	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL2261152	113112	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL2261152	113112	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL3139166	113112	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL3139166	113112	0	None	-	1	Guinea pig	7.6	pKd	=	7.6	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	297	4	0	3	3.1	CN(C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		76312110	113214	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		76312110	113214	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL2261144	113214	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL2261144	113214	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL3139691	113214	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL3139691	113214	0	None	-	1	Guinea pig	7.5	pKd	=	7.5	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		10365181	25329	0	None	-38	3	Rat	7.5	pKd	=	7.5	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
		CHEMBL127587	25329	0	None	-38	3	Rat	7.5	pKd	=	7.5	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
		44373347	126343	0	None	1	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	349	4	2	3	3.8	C[C@H](O)[C@H]1[C@@H](CO)C[C@H]2CCCC[C@@H]2[C@H]1/C=C/[C@H]1CCC[C@H](C)N1C	10.1016/0960-894X(94)00459-S
		CHEMBL346049	126343	0	None	1	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	349	4	2	3	3.8	C[C@H](O)[C@H]1[C@@H](CO)C[C@H]2CCCC[C@@H]2[C@H]1/C=C/[C@H]1CCC[C@H](C)N1C	10.1016/0960-894X(94)00459-S
		137628879	167751	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	167751	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	167751	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	167751	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		44457825	169972	0	None	-1	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCCC1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL418189	169972	0	None	-1	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCCC1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		324	8706	15	None	-1	9	Rat	8.5	pKd	=	8.5	Binding	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		6436265	8706	15	None	-1	9	Rat	8.5	pKd	=	8.5	Binding	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		CHEMBL277642	8706	15	None	-1	9	Rat	8.5	pKd	=	8.5	Binding	Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.Dissociation constant for the blocking of cardiac muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		11968014	19530	5	None	-3	9	Rat	8.5	pKd	=	8.5	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
		CHEMBL1187846	19530	5	None	-3	9	Rat	8.5	pKd	=	8.5	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm00170a010
		156015978	185102	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	185102	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	185102	0	None	1	5	Human	8.5	pKd	=	8.5	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44457832	92398	0	None	-2	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL22829	92398	0	None	-2	2	Rat	8.5	pKd	=	8.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.8	CN1CCCC[C@@H]1/C=C/C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		162645430	190406	0	None	-1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4744233	190406	0	None	-1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802409	190406	0	None	-1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	860	15	2	7	8.2	Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		162645520	190407	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4742721	190407	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802414	190407	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		44457828	168659	0	None	-1	2	Rat	7.5	pKd	=	7.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL415037	168659	0	None	-1	2	Rat	7.5	pKd	=	7.5	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	303	2	0	1	4.9	CN1CCCC[C@H]1CC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		44373093	60877	0	None	-2	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	331	2	0	2	4.9	C[C@@H]1OC[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]21	10.1016/0960-894X(94)00459-S
		CHEMBL160666	60877	0	None	-2	2	Rat	6.5	pKd	=	6.5	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	331	2	0	2	4.9	C[C@@H]1OC[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]21	10.1016/0960-894X(94)00459-S
		57664406	9177	50	None	-1	2	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		6938	9177	50	None	-1	2	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089376	9177	50	None	-1	2	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		156016041	185026	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	185026	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	185026	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		162677513	190523	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4789147	190523	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		CHEMBL4803695	190523	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	983	17	3	11	6.2	CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1039/d0md00137f
		156016041	185026	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	185026	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	185026	0	None	1	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding studyBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark at 22 degree C for 2 hrs by FACSCalibur flow cytometric saturation binding study	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		162645520	190407	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4742721	190407	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		CHEMBL4802414	190407	0	None	-10	5	Human	8.4	pKd	=	8.4	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to controlBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells assessed as unspecific binding at Kd incubated in dark at 22 degree C for 2 hrs in presence of atropine by FACSCantoII flow cytometric saturation binding study relative to control	ChEMBL	1117	25	4	11	9.5	O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1039/d0md00137f
		137628879	167751	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	167751	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	167751	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	167751	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate assessed as ratio of dissociation rate constant to association rate constant after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		324	8706	15	None	-1	9	Rat	8.3	pKd	=	8.3	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		6436265	8706	15	None	-1	9	Rat	8.3	pKd	=	8.3	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		CHEMBL277642	8706	15	None	-1	9	Rat	8.3	pKd	=	8.3	Binding	Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.Dissociation constant for the blocking of brainstem muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		156015807	185078	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	185078	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	185078	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		10055202	18305	1	None	5	2	Human	6.4	pKd	=	6.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm100293f
		CHEMBL11805	18305	1	None	5	2	Human	6.4	pKd	=	6.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	667	27	0	6	7.6	COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC	10.1021/jm100293f
		10365181	25329	0	None	-38	3	Rat	7.4	pKd	=	7.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
		CHEMBL127587	25329	0	None	-38	3	Rat	7.4	pKd	=	7.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue	ChEMBL	427	5	1	4	2.9	O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(C/C=C/I)c1ccccc1	10.1021/jm00020a004
		15038486	92543	0	None	-3	3	Human	5.4	pKd	=	5.4	Binding	Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
		CHEMBL22923	92543	0	None	-3	3	Human	5.4	pKd	=	5.4	Binding	Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.	ChEMBL	237	3	0	3	2.4	C[C@@H]1OC(=O)C[C@H]1C/C=C/[C@H]1CCCCN1C	10.1016/S0960-894X(00)80534-X
		167962	10841	4	None	-	1	Human	6.3	pKd	=	6.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	10841	4	None	-	1	Human	6.3	pKd	=	6.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	10841	4	None	-	1	Human	6.3	pKd	=	6.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by competition binding assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		44373067	58679	0	None	5	2	Rat	6.3	pKd	=	6.3	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	431	3	0	4	5.8	C[C@@H]1O[C@H](OC(=O)C(C)(C)C)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
		CHEMBL158589	58679	0	None	5	2	Rat	6.3	pKd	=	6.3	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	431	3	0	4	5.8	C[C@@H]1O[C@H](OC(=O)C(C)(C)C)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
		9979830	19819	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
		9979830	19819	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL1190002	19819	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL1190002	19819	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL539879	19819	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL539879	19819	0	None	-	1	Guinea pig	8.3	pKd	=	8.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	298	4	0	2	3.0	C[N+](C)(C)CC1COC(c2ccccc2)(c2ccccc2)O1	10.1007/s00044-006-0143-5
		156015807	185078	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	185078	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	185078	0	None	3	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		156015978	185102	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	185102	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	185102	0	None	1	5	Human	8.3	pKd	=	8.3	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		11957991	113218	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		11957991	113218	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL2261154	113218	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL2261154	113218	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		CHEMBL3139733	113218	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-005-0139-6
		CHEMBL3139733	113218	0	None	-	1	Guinea pig	6.3	pKd	=	6.3	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	4	0	2	3.4	C[S+](C)[C@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)OC1	10.1007/s00044-006-0143-5
		76319430	113220	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL2262220	113220	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL3139826	113220	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		76330179	113221	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL2261145	113221	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL3139827	113221	0	None	-	1	Guinea pig	7.2	pKd	=	7.2	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	312	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		14753637	20261	0	None	-1	3	Rat	8.2	pKd	=	8.2	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL1193366	20261	0	None	-1	3	Rat	8.2	pKd	=	8.2	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		CHEMBL544759	20261	0	None	-1	3	Rat	8.2	pKd	=	8.2	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	ChEMBL	330	4	2	5	1.3	CC(=N)N1C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12	10.1021/jm00170a010
		324	8706	15	None	-1	9	Rat	8.2	pKd	=	8.2	Binding	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		6436265	8706	15	None	-1	9	Rat	8.2	pKd	=	8.2	Binding	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		CHEMBL277642	8706	15	None	-1	9	Rat	8.2	pKd	=	8.2	Binding	Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.Dissociation constant for the blocking of heart muscarinic M2 receptor was reported.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80534-X
		71720488	93728	0	None	2	3	Guinea pig	6.2	pKd	=	6.2	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323441	93728	0	None	2	3	Guinea pig	6.2	pKd	=	6.2	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		44457844	92590	0	None	1	2	Rat	6.2	pKd	=	6.2	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	301	2	0	1	5.5	CN1CCCCC1/C=C/c1c2ccccc2cc2ccccc12	10.1016/S0960-894X(00)80325-X
		CHEMBL22962	92590	0	None	1	2	Rat	6.2	pKd	=	6.2	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	301	2	0	1	5.5	CN1CCCCC1/C=C/c1c2ccccc2cc2ccccc12	10.1016/S0960-894X(00)80325-X
		44457834	91492	0	None	-1	2	Rat	8.1	pKd	=	8.1	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.3	CN1CCCCC1CCC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		CHEMBL22278	91492	0	None	-1	2	Rat	8.1	pKd	=	8.1	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	317	3	0	1	5.3	CN1CCCCC1CCC=C1c2ccccc2Cc2ccccc21	10.1016/S0960-894X(00)80325-X
		137628879	167751	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	167751	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	167751	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	167751	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assayBinding affinity to human muscarinic acetylcholine receptor M2 expressed in live adherent CHOK9 cells after 2 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		156015153	185086	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	185086	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	185086	0	None	1	5	Human	8.1	pKd	=	8.1	Binding	Binding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayBinding affinity to human muscarinic M2 receptor expressed in CHO-K9 cells incubated in dark measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		76308444	113215	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		76308444	113215	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL2261149	113215	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL2261149	113215	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		CHEMBL3139712	113215	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-005-0139-6
		CHEMBL3139712	113215	0	None	-	1	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hrAntagonist activity at Cavia porcellus (guinea pig) left atria M2 receptor after 2 hr	ChEMBL	315	5	0	2	3.4	C[S+](C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1007/s00044-006-0143-5
		71716836	93729	0	None	4	3	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323442	93729	0	None	4	3	Guinea pig	6.1	pKd	=	6.1	Binding	Antagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardiaAntagonist activity at muscarinic M2 receptor in guinea pig left atria assessed as inhibition of carbachol-induced bradycardia	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		10318189	61005	0	None	9	2	Rat	7.1	pKd	=	7.1	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	389	3	0	4	4.8	CC(=O)O[C@H]1O[C@@H](C)[C@@H]2[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]3CCCC[C@@H]3C[C@H]12	10.1016/0960-894X(94)00459-S
		CHEMBL160755	61005	0	None	9	2	Rat	7.1	pKd	=	7.1	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	389	3	0	4	4.8	CC(=O)O[C@H]1O[C@@H](C)[C@@H]2[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]3CCCC[C@@H]3C[C@H]12	10.1016/0960-894X(94)00459-S
		324	8706	15	None	-1	9	Rat	8.0	pKd	=	8.0	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
		6436265	8706	15	None	-1	9	Rat	8.0	pKd	=	8.0	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
		CHEMBL277642	8706	15	None	-1	9	Rat	8.0	pKd	=	8.0	Binding	Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/S0960-894X(00)80325-X
		44373049	59340	0	None	4	2	Rat	7.0	pKd	=	7.0	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	347	2	1	3	4.2	C[C@@H]1O[C@H](O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
		CHEMBL159237	59340	0	None	4	2	Rat	7.0	pKd	=	7.0	Binding	Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)Binding affinity against M2 receptor in rat brainstem cells using radioligand [3H]quinuclidinyl benzilate ([3H]QNB)	ChEMBL	347	2	1	3	4.2	C[C@@H]1O[C@H](O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/0960-894X(94)00459-S
		9916852	211698	0	None	-	1	Human	11.0	pKi	=	11	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
		CHEMBL76164	211698	0	None	-	1	Human	11.0	pKi	=	11	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
		9916852	211698	0	None	-	1	Human	11.0	pKi	=	11	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL76164	211698	0	None	-	1	Human	11.0	pKi	=	11	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	606	8	0	9	3.4	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		367	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		5487427	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		8592	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		CHEMBL1900528	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		CHEMBL3305968	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		CHEMBL4650755	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		DB01409	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Binding affinity to human M2 receptorBinding affinity to human M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm401219y
		367	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		5487427	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		8592	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL1900528	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL3305968	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL4650755	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		DB01409	10596	12	None	-2	8	Human	10.7	pKi	=	10.7	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		59291417	119600	0	None	-1	3	Rat	10.6	pKi	=	10.6	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298595	119600	0	None	-1	3	Rat	10.6	pKi	=	10.6	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307168	119600	0	None	-1	3	Rat	10.6	pKi	=	10.6	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	343	3	1	3	4.3	C[N+]12CCC(OC(=O)Nc3ccsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		688566	202662	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00059a009
		CHEMBL558910	202662	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00059a009
		71452756	86316	0	None	2	4	Human	10.5	pKi	=	10.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		CHEMBL2114068	86316	0	None	2	4	Human	10.5	pKi	=	10.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		44378845	63931	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H]1CN(C2CCCCC2)CCN1[C@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL164705	63931	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H]1CN(C2CCCCC2)CCN1[C@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(02)00023-9
		44378762	126706	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCCCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		CHEMBL349497	126706	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	470	5	0	6	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCCCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		44324892	118342	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328094	118342	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		688566	202662	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00114a005
		CHEMBL558910	202662	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00114a005
		688566	202662	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/S0960-894X(97)00143-1
		CHEMBL558910	202662	24	None	-1	3	Rat	10.5	pKi	=	10.5	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/S0960-894X(97)00143-1
		44325018	213653	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	638	8	0	9	4.8	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL90700	213653	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	638	8	0	9	4.8	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44378811	126879	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL350956	126879	0	None	-	1	Human	10.4	pKi	=	10.4	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		23056	6900	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
		318	6900	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
		3260	6900	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL12980	6900	29	None	-1	8	Human	10.4	pKi	=	10.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00003a011
		25005841	119597	0	None	-1	3	Rat	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298599	119597	0	None	-1	3	Rat	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307130	119597	0	None	-1	3	Rat	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.4	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		16065402	74702	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	428	9	1	3	4.8	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2ccccc2)C1	10.1021/jm200884j
		CHEMBL1910848	74702	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	428	9	1	3	4.8	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2ccccc2)C1	10.1021/jm200884j
		71454563	86431	0	None	5	4	Human	10.2	pKi	=	10.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		CHEMBL2115128	86431	0	None	5	4	Human	10.2	pKi	=	10.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	423	6	0	3	5.9	C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		10143956	20683	0	None	1	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL1196359	20683	0	None	1	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		CHEMBL556635	20683	0	None	1	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	470	9	1	5	4.7	O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1	10.1021/jm900132z
		367	10596	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		5487427	10596	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		8592	10596	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL1900528	10596	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL3305968	10596	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		CHEMBL4650755	10596	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		DB01409	10596	12	None	-2	8	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm200884j
		155566290	183359	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	183359	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	183359	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155550632	183308	0	None	19	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4540949	183308	0	None	19	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597071	183308	0	None	19	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	845	22	8	10	1.9	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155566290	183359	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	183359	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	183359	0	None	25	5	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		316	9611	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	9611	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	9611	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	9611	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	9611	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	9611	19	None	-6	9	Human	10.2	pKi	=	10.2	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		44343733	20204	0	None	-	1	Rat	10.2	pKi	=	10.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	6	0	8	4.8	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
		CHEMBL119294	20204	0	None	-	1	Rat	10.2	pKi	=	10.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	6	0	8	4.8	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
		9827782	110330	0	None	41	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL308566	110330	0	None	41	3	Human	10.2	pKi	=	10.2	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00553-9
		15407089	214231	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	6	0	9	3.8	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL94189	214231	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	6	0	9	3.8	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		10457079	16802	0	None	-4	2	Human	10.1	pKi	=	10.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL115078	16802	0	None	-4	2	Human	10.1	pKi	=	10.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		155566290	183359	0	None	25	5	Human	10.1	pKi	=	10.1	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582879	183359	0	None	25	5	Human	10.1	pKi	=	10.1	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597498	183359	0	None	25	5	Human	10.1	pKi	=	10.1	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		164611865	195255	0	None	15	3	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4856113	195255	0	None	15	3	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028107	195255	0	None	15	3	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		155525097	177729	0	None	18	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	712	13	1	10	5.5	CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4455570	177729	0	None	18	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	712	13	1	10	5.5	CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155567380	183187	0	None	20	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4589047	183187	0	None	20	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596064	183187	0	None	20	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	981	20	7	10	4.7	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155521894	183204	0	None	11	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451383	183204	0	None	11	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596183	183204	0	None	11	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		155550436	183280	0	None	14	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4569639	183280	0	None	14	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596780	183280	0	None	14	5	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	852	20	6	10	3.6	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		11434515	7049	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		11519741	7049	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		4484	7049	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		7449	7049	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		CHEMBL1194325	7049	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		DB08897	7049	6	None	-6	5	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1021/jm900132z
		11852298	20798	0	None	-1	3	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL1197251	20798	0	None	-1	3	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		CHEMBL564057	20798	0	None	-1	3	Human	10.1	pKi	=	10.1	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	454	7	1	5	4.4	O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1	10.1021/jm900132z
		44378875	63963	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	7	0	8	4.6	COc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL164935	63963	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	7	0	8	4.6	COc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44379051	64862	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	667	8	0	8	6.4	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Oc3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL167396	64862	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	667	8	0	8	6.4	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Oc3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		10461523	127027	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	6	0	9	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3cccc4c3OCO4)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL352291	127027	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	6	0	9	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3cccc4c3OCO4)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		44379021	127038	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	609	6	0	7	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL352380	127038	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	609	6	0	7	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		367	10596	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		5487427	10596	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		8592	10596	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL1900528	10596	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL3305968	10596	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		CHEMBL4650755	10596	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		DB01409	10596	12	None	-2	8	Human	10.0	pKi	=	10	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm900132z
		44274333	17918	0	None	-5	2	Rat	10.0	pKi	=	10	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
		CHEMBL1178341	17918	0	None	-5	2	Rat	10.0	pKi	=	10	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
		CHEMBL21812	17918	0	None	-5	2	Rat	10.0	pKi	=	10	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	358	4	1	3	3.2	C[N+]12CCC(CC1)[C@@H](OC(=O)[C@](O)(c1ccccc1)C1CCCCC1)C2	10.1021/jm960374w
		11431874	81055	0	None	1	3	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
		CHEMBL2023762	81055	0	None	1	3	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
		CHEMBL2023764	81055	0	None	1	3	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneDisplacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membrane	ChEMBL	413	9	0	1	6.6	C=CCCCC[N+]1(C)C2CCC1CC(CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2012.02.015
		155566290	183359	0	None	25	5	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4582879	183359	0	None	25	5	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4597498	183359	0	None	25	5	Human	10.0	pKi	=	10	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	24	9	11	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164622681	195341	0	None	7	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4864727	195341	0	None	7	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028712	195341	0	None	7	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164616463	195293	0	None	14	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
		CHEMBL4859378	195293	0	None	14	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
		CHEMBL5028381	195293	0	None	14	3	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	860	22	9	12	0.9	C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN	10.1016/j.ejmech.2021.113159
		137630050	167819	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		9827782	110330	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL308566	110330	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		9827782	110330	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL308566	110330	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		15453419	214240	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	7	0	8	5.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL94247	214240	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	7	0	8	5.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		9827782	110330	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL308566	110330	0	None	41	3	Human	10.0	pKi	=	10.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	512	7	0	6	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
		140844407	183411	0	None	4	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4519930	183411	0	None	4	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597916	183411	0	None	4	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3ccc(Cl)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		155539713	183139	0	None	20	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4515788	183139	0	None	20	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595691	183139	0	None	20	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44431393	94799	0	None	1	3	Human	9.9	pKi	=	9.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234440	94799	0	None	1	3	Human	9.9	pKi	=	9.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	10.1016/j.bmcl.2006.11.058
		59291241	119592	0	None	-2	3	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298596	119592	0	None	-2	3	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307116	119592	0	None	-2	3	Rat	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.7	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccccc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		9809330	122777	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
		CHEMBL335542	122777	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	552	16	0	13	2.3	CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm0301235
		15407088	213772	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	528	6	0	8	3.8	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL91404	213772	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	528	6	0	8	3.8	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44292486	188290	0	None	-	1	Rat	9.9	pKi	=	9.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		CHEMBL47650	188290	0	None	-	1	Rat	9.9	pKi	=	9.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		16065403	74710	23	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	444	9	2	4	4.5	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1	10.1021/jm200884j
		CHEMBL1910856	74710	23	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	444	9	2	4	4.5	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1	10.1021/jm200884j
		316	9611	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		317	9611	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		71183	9611	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL3140030	9611	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL376897	9611	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		DB00462	9611	19	None	-6	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		44610056	130769	0	None	1	5	Human	9.9	pKi	=	9.9	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin)Antagonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL	704	14	5	9	5.5	O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2015.10.008
		CHEMBL3629360	130769	0	None	1	5	Human	9.9	pKi	=	9.9	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin)Antagonist activity at muscarinic M2 receptor (unknown origin)	ChEMBL	704	14	5	9	5.5	O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1	10.1016/j.bmcl.2015.10.008
		10274019	211030	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	3	6.0	COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL71124	211030	0	None	-1	5	Human	9.9	pKi	=	9.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	3	6.0	COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44378846	63941	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL164762	63941	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)[C@H](C)C3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		164622945	195344	0	None	6	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		CHEMBL4871700	195344	0	None	6	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		CHEMBL5028723	195344	0	None	6	3	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	646	14	6	7	3.6	N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		155523648	183372	0	None	5	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4454300	183372	0	None	5	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597576	183372	0	None	5	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	909	18	6	9	5.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		15463388	172471	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL424530	172471	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		49800047	21255	1	None	-1	5	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		CHEMBL1201024	21255	1	None	-1	5	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		CHEMBL1201268	21255	1	None	-1	5	Human	9.8	pKi	=	9.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	1	4	1.1	C[N+]1(C)[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@H]1O[C@@H]21	nan
		367	10596	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		5487427	10596	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		8592	10596	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		CHEMBL1900528	10596	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		CHEMBL3305968	10596	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		CHEMBL4650755	10596	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		DB01409	10596	12	None	-19	8	Rat	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2014.04.031
		11519069	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		11519070	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		4816	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		7354	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		CHEMBL1187833	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		DB09076	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm801601v
		164615275	195286	0	None	8	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4861252	195286	0	None	8	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028304	195286	0	None	8	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	20	9	11	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		367	10596	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		5487427	10596	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		8592	10596	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		CHEMBL1900528	10596	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		CHEMBL3305968	10596	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		CHEMBL4650755	10596	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		DB01409	10596	12	None	-2	8	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.1c00204
		25195533	85161	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL2103803	85161	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL2110584	85161	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		9984928	211462	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL73893	211462	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44325048	118334	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	558	7	0	8	4.1	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328059	118334	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	558	7	0	8	4.1	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		9984928	211462	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL73893	211462	0	None	199	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	8	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44379026	127080	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL352739	127080	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		14537188	143324	0	None	1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1016/j.bmc.2013.01.072
		CHEMBL37372	143324	0	None	1	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1016/j.bmc.2013.01.072
		9867847	211037	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		CHEMBL71147	211037	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		9867847	211037	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL71147	211037	0	None	1	4	Human	9.8	pKi	=	9.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	439	6	0	4	5.6	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00457-1
		25195533	85161	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
		CHEMBL2103803	85161	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
		CHEMBL2110584	85161	2	None	-2	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	345	4	0	1	4.9	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1021/jm900736e
		155556290	183235	0	None	7	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4554682	183235	0	None	7	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596434	183235	0	None	7	5	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	923	22	7	11	3.1	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44337753	115778	0	None	-	1	Rat	9.8	pKi	=	9.8	Binding	Compound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligandCompound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligand	ChEMBL	351	4	1	4	2.9	CN1CC2CC1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm00115a003
		CHEMBL321214	115778	0	None	-	1	Rat	9.8	pKi	=	9.8	Binding	Compound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligandCompound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligand	ChEMBL	351	4	1	4	2.9	CN1CC2CC1C[C@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm00115a003
		316	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		317	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		71183	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		CHEMBL3140030	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		CHEMBL376897	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		DB00462	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm061374r
		164626501	195375	0	None	7	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4874955	195375	0	None	7	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028936	195375	0	None	7	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		316	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		317	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		71183	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		CHEMBL3140030	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		CHEMBL376897	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		DB00462	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm2013216
		316	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		317	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		71183	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		CHEMBL3140030	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		CHEMBL376897	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		DB00462	9611	19	None	-6	9	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm901048j
		140844416	183385	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4516342	183385	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597717	183385	0	None	12	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	524	8	1	3	5.7	O=C(OC1C[N+]2(CCCc3ccc(C(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		23056	6900	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
		318	6900	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
		3260	6900	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
		CHEMBL12980	6900	29	None	-5	8	Rat	9.7	pKi	=	9.7	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	10.1021/jm00010a016
		156014450	185030	0	None	2	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4636083	185030	0	None	2	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650652	185030	0	None	2	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	518	9	2	6	3.4	NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		164617895	195304	0	None	41	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4852868	195304	0	None	41	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028466	195304	0	None	41	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	24	10	13	-0.5	CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164627113	195381	0	None	13	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4878646	195381	0	None	13	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028981	195381	0	None	13	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	489	7	2	5	4.2	NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164611189	195250	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4851514	195250	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028061	195250	0	None	2	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	944	24	11	12	0.6	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164614083	195270	0	None	4	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4855492	195270	0	None	4	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028231	195270	0	None	4	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015648	185094	0	None	8	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4641328	185094	0	None	8	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4651078	185094	0	None	8	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1021	18	5	12	5.5	NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL5074599	221098	2	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL		None	None	None		COc1ccc([C@H](Cc2c(Cl)c[n+]([O-])cc2Cl)OC(=O)c2ccc(CNC(C(=O)O[C@H]3CN4CCC3CC4)c3ccccc3)s2)cc1OC	10.1021/acs.jmedchem.1c00204
		9937474	177249	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4448933	177249	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1016/j.ejmech.2021.113159
		9937474	177249	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4448933	177249	0	None	363	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	551	6	1	5	5.3	Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44378842	64197	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	577	8	0	8	3.5	CCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL165375	64197	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	577	8	0	8	3.5	CCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		44378601	175362	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	591	9	0	8	3.9	CCCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL435849	175362	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	591	9	0	8	3.9	CCCCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		15407074	64198	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	589	6	0	7	4.9	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL165377	64198	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	589	6	0	7	4.9	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44379050	168287	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	709	9	0	9	6.0	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3COC(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL412814	168287	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	709	9	0	9	6.0	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3COC(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		10109130	139793	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL370232	139793	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2cccs2)c2cccs2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		9894236	67003	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	568	6	0	8	4.8	Cc1ccsc1C(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL174070	67003	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	568	6	0	8	4.8	Cc1ccsc1C(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		15392110	112262	0	None	6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	412	5	0	4	4.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL312085	112262	0	None	6	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	412	5	0	4	4.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		164618444	195308	0	None	9	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4852186	195308	0	None	9	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028499	195308	0	None	9	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	21	9	11	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164625454	195370	0	None	3	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862735	195370	0	None	3	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028885	195370	0	None	3	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	1001	26	12	13	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		11798681	17921	0	None	-20	2	Rat	9.7	pKi	=	9.7	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
		CHEMBL1178344	17921	0	None	-20	2	Rat	9.7	pKi	=	9.7	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
		CHEMBL21905	17921	0	None	-20	2	Rat	9.7	pKi	=	9.7	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	346	4	1	3	3.2	C[N+]1(C)CCC(OC(=O)[C@](O)(c2ccccc2)C2CCCCC2)CC1	10.1021/jm960374w
		59291493	119599	0	None	-2	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298600	119599	0	None	-2	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307158	119599	0	None	-2	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	362	3	1	4	3.9	C[N+]12CCC(OC(=O)Nc3ncsc3-c3ccc(F)cc3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		164627445	195386	0	None	14	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4876453	195386	0	None	14	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028997	195386	0	None	14	5	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	8	11	1.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164628529	195393	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		CHEMBL4876725	195393	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		CHEMBL5029058	195393	0	None	5	3	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	914	17	9	12	0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		10101246	16318	0	None	-81	2	Human	9.6	pKi	=	9.6	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL112297	16318	0	None	-81	2	Human	9.6	pKi	=	9.6	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		164624669	195365	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4870127	195365	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028837	195365	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	674	15	6	8	2.1	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		688566	202662	24	None	-1	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		CHEMBL558910	202662	24	None	-1	3	Rat	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		164624066	195359	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4864987	195359	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028806	195359	0	None	3	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	787	18	7	10	1.8	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		155560305	183032	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4568151	183032	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4594890	183032	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	801	19	5	9	2.8	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		164610746	195246	0	None	34	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4854886	195246	0	None	34	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028038	195246	0	None	34	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164621305	195331	0	None	29	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4863285	195331	0	None	29	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028642	195331	0	None	29	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015900	185100	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4643273	185100	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651104	185100	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1687	34	6	18	11.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21	10.1021/acs.jmedchem.9b02172
		10324012	211485	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL74117	211485	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		10324012	211485	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL74117	211485	0	None	263	2	Human	9.6	pKi	=	9.6	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	508	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C3CC3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		132947	10636	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
		361	10636	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
		CHEMBL265256	10636	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/s0960-894x(01)00186-x
		155519740	177185	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting method	ChEMBL	1125	29	4	14	9.6	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.8b01967
		CHEMBL4448108	177185	0	None	5	5	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 3 hrs by beta counting method	ChEMBL	1125	29	4	14	9.6	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.8b01967
		156015724	185053	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4643159	185053	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650839	185053	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1302	29	7	15	8.1	NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		164610955	195248	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		CHEMBL4858398	195248	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		CHEMBL5028048	195248	0	None	15	3	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	661	15	6	8	2.3	N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O	10.1016/j.ejmech.2021.113159
		132947	10636	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
		361	10636	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
		CHEMBL265256	10636	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00075a032
		164619001	195315	0	None	3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4871153	195315	0	None	3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028529	195315	0	None	3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	887	22	9	11	2.3	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		132947	10636	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
		361	10636	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
		CHEMBL265256	10636	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm00046a021
		44311771	171011	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL421113	171011	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311771	171011	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL421113	171011	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311771	171011	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL421113	171011	0	None	34	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	546	9	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCC)CC2)CC1	10.1016/s0960-894x(01)00100-7
		164628352	195392	0	None	9	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4878717	195392	0	None	9	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5029051	195392	0	None	9	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	630	13	5	6	4.0	N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44312007	175944	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL440491	175944	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44312007	175944	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL440491	175944	0	None	34	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	8	0	6	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		15463387	63309	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL163777	63309	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	456	6	0	5	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		44378810	64205	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.4	COc1ccc(S(=O)(=O)c2ccc(CN3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL165439	64205	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.4	COc1ccc(S(=O)(=O)c2ccc(CN3CCN(C4CCCCC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		44378876	64910	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	615	6	0	8	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3sccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL167816	64910	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	615	6	0	8	5.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3sccc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		44378952	126678	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)cc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL349142	126678	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)cc3Cl)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		132947	10636	9	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
		361	10636	9	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
		CHEMBL265256	10636	9	None	1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1016/j.bmc.2008.06.025
		132947	10636	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
		361	10636	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
		CHEMBL265256	10636	9	None	-1	9	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	10.1021/jm981038d
		164612662	195261	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4847898	195261	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028154	195261	0	None	2	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	845	20	8	11	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44292836	108094	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
		CHEMBL296633	108094	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
		372625	107924	11	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL295388	107924	11	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		164613559	195265	0	None	38	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4856659	195265	0	None	38	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028196	195265	0	None	38	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	874	21	9	12	0.2	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		372625	107924	11	None	-1	5	Rat	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting methodDisplacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting method	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL295388	107924	11	None	-1	5	Rat	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting methodDisplacement of [3H]-NMS from rat heart muscarinic M2 receptor after 60 mins by scintillation counting method	ChEMBL	462	9	1	4	5.1	CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		367	10596	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		5487427	10596	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		8592	10596	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		CHEMBL1900528	10596	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		CHEMBL3305968	10596	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		CHEMBL4650755	10596	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		DB01409	10596	12	None	-2	8	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmcl.2008.03.024
		316	9611	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	9611	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	9611	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	9611	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	9611	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	9611	19	None	-6	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		164619973	195320	0	None	33	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862996	195320	0	None	33	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028571	195320	0	None	33	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	23	9	12	1.0	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		174174	7311	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		260	7311	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		320	7311	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		CHEMBL517712	7311	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		DB00572	7311	49	None	-7	14	Human	9.5	pKi	=	9.5	Binding	muscarinic acetylcholine receptor M1muscarinic acetylcholine receptor M1	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00108a030
		44311784	211258	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72408	211258	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		174174	7311	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		260	7311	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		320	7311	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		CHEMBL517712	7311	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		DB00572	7311	49	None	-1	14	Mouse	9.5	pKi	=	9.5	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		44311784	211258	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72408	211258	0	None	28	2	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	540	9	0	6	5.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		137630050	167819	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089543	167819	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4097258	167819	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4116470	167819	0	None	1	5	Human	9.5	pKi	=	9.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		164617401	195299	0	None	12	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		CHEMBL4852646	195299	0	None	12	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		CHEMBL5028427	195299	0	None	12	3	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	900	16	9	12	-0.2	CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1	10.1016/j.ejmech.2021.113159
		155543944	183113	0	None	8	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4567026	183113	0	None	8	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595467	183113	0	None	8	5	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	873	21	6	10	2.3	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44311717	211268	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72494	211268	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311717	211268	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72494	211268	0	None	102	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	580	8	0	6	5.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		155535606	178831	0	None	4	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	1077	20	5	12	6.0	CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.8b01967
		CHEMBL4471882	178831	0	None	4	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	1077	20	5	12	6.0	CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1	10.1021/acs.jmedchem.8b01967
		9953227	210976	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	407	6	0	3	6.9	C=C(c1ccc(Sc2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		CHEMBL70828	210976	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	407	6	0	3	6.9	C=C(c1ccc(Sc2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00437-6
		10628017	28488	0	None	1	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		CHEMBL131865	28488	0	None	1	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	650	26	3	7	7.0	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		44311718	211250	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72363	211250	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311760	211278	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72551	211278	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44292858	108124	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	397	7	1	4	3.5	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCCF)cc1	10.1021/jm00010a016
		CHEMBL296895	108124	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	397	7	1	4	3.5	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CCCF)cc1	10.1021/jm00010a016
		44311718	211250	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72363	211250	0	None	151	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	560	10	0	6	4.8	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311760	211278	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72551	211278	0	None	109	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	8	0	5	5.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		164623076	195346	0	None	17	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4872608	195346	0	None	17	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028732	195346	0	None	17	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		939077	201847	2	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		CHEMBL549577	201847	2	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		9809222	120870	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL332703	120870	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44378764	64020	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	559	6	0	5	5.5	Cc1cccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c1	10.1016/s0960-894x(02)00024-0
		CHEMBL165035	64020	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	559	6	0	5	5.5	Cc1cccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c1	10.1016/s0960-894x(02)00024-0
		10291977	79673	0	None	-5	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2ccsc2)c2ccsc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200401	79673	0	None	-5	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	359	3	1	5	3.2	CO[C@]1(C#CC(O)(c2ccsc2)c2ccsc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44344122	117194	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL324484	117194	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	7	1	8	4.6	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		15870384	66011	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	576	6	0	7	5.0	Cc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CC3)CC2)c1C	10.1016/s0960-894x(01)00100-7
		CHEMBL170298	66011	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	576	6	0	7	5.0	Cc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CC3)CC2)c1C	10.1016/s0960-894x(01)00100-7
		134272442	183267	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4457734	183267	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596671	183267	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	4	4.9	O=C(OC1C[N+]2(CCSc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		137630050	167819	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		44312024	211340	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72957	211340	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		137630050	167819	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		44312024	211340	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72957	211340	0	None	36	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	7	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		25897919	62426	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		657309	62426	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		CHEMBL1464005	62426	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		CHEMBL1621597	62426	14	None	-1	8	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		155554568	183388	0	None	5	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4548432	183388	0	None	5	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597724	183388	0	None	5	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	702	14	4	8	2.6	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.8b01967
		316	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		6604314	37752	3	None	-3	2	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	352	4	1	3	2.7	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm960374w
		CHEMBL1398637	37752	3	None	-3	2	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	352	4	1	3	2.7	C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2	10.1021/jm960374w
		11434515	7049	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		11519741	7049	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		4484	7049	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		7449	7049	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		CHEMBL1194325	7049	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		DB08897	7049	6	None	-6	5	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1016/j.bmc.2019.06.016
		316	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	9611	19	None	-6	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		11766733	162533	0	None	-2	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		CHEMBL1202003	162533	0	None	-2	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		CHEMBL405739	162533	0	None	-2	5	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1121	29	4	10	12.0	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		44344164	17757	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)cc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL117351	17757	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)cc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44311823	210983	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL70860	210983	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311823	210983	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL70860	210983	0	None	23	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	574	8	0	6	6.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		688520	42189	3	None	4	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		CHEMBL1437876	42189	3	None	4	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		CHEMBL3289390	42189	3	None	4	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		44311987	211381	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL73245	211381	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		59291402	119563	0	None	-8	3	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298588	119563	0	None	-8	3	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305766	119563	0	None	-8	3	Rat	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1ccsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		44311987	211381	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL73245	211381	0	None	162	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	532	8	0	6	4.1	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		16116083	19068	0	None	-1	5	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL1184884	19068	0	None	-1	5	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL375969	19068	0	None	-1	5	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		129486	106931	6	None	-5	2	Human	9.3	pKi	=	9.3	Binding	Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3	ChEMBL	349	4	0	3	4.0	CN1CC2CC(OC(=O)C(C)(c3ccccc3)c3ccccc3)CC1C2	10.1021/jm00108a030
		CHEMBL287868	106931	6	None	-5	2	Human	9.3	pKi	=	9.3	Binding	Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3	ChEMBL	349	4	0	3	4.0	CN1CC2CC(OC(=O)C(C)(c3ccccc3)c3ccccc3)CC1C2	10.1021/jm00108a030
		25897919	62426	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		657309	62426	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		CHEMBL1464005	62426	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		CHEMBL1621597	62426	14	None	-1	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm200884j
		367	10596	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		5487427	10596	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		8592	10596	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		CHEMBL1900528	10596	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		CHEMBL3305968	10596	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		CHEMBL4650755	10596	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		DB01409	10596	12	None	-2	8	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1016/j.bmc.2019.06.016
		155520948	183208	0	None	3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4450188	183208	0	None	3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596191	183208	0	None	3	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3ccc(F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		44379040	126890	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	1	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3N)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL351079	126890	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	1	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3N)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		302	9751	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		4630	9751	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL7634	9751	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		302	9751	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		4630	9751	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL7634	9751	25	None	-4	8	Rat	9.3	pKi	=	9.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		9851621	65953	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	6	0	7	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL170033	65953	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	6	0	7	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		44382606	127573	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2ncccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL355511	127573	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2ncccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		44232952	110160	0	None	-10	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084650	110160	0	None	-10	3	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	330	4	0	2	4.8	CN1[C@H]2CC[C@@H]1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		10009554	211490	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/acs.jmedchem.1c00790
		CHEMBL74141	211490	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/acs.jmedchem.1c00790
		10009554	211490	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/jm0255163
		CHEMBL74141	211490	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccc(F)c7ccccc67)CC5)CC4)OCCO3)cc2)cc1	10.1021/jm0255163
		44215377	18864	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(F)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL118391	18864	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(F)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		137630050	167819	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089543	167819	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4097258	167819	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		CHEMBL4116470	167819	0	None	1	5	Human	9.3	pKi	=	9.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.9b02172
		156015807	185078	0	None	3	5	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641726	185078	0	None	3	5	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650973	185078	0	None	3	5	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1185	25	3	12	9.5	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44344216	20002	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(N)ccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL119131	20002	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(N)ccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44344106	119849	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL331214	119849	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44343862	17283	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	604	7	0	7	5.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL116777	17283	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	604	7	0	7	5.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		10771937	28465	0	None	2	5	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		CHEMBL1202004	28465	0	None	2	5	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		CHEMBL131846	28465	0	None	2	5	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	871	27	4	8	9.4	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1021/jm981038d
		316	9611	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		317	9611	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		71183	9611	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL3140030	9611	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL376897	9611	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		DB00462	9611	19	None	-6	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		164616706	195294	0	None	6	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4850130	195294	0	None	6	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028391	195294	0	None	6	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	660	14	6	8	1.7	N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015042	185013	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
		CHEMBL4645845	185013	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650549	185013	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	571	12	3	7	3.7	NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.9b02172
		44311785	211516	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL74352	211516	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311785	211516	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL74352	211516	0	None	69	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	526	8	0	6	5.3	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44312451	111563	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL310912	111563	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(02)00023-9
		15407073	126738	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL349720	126738	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		44379055	127293	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	8	0	7	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1	10.1016/s0960-894x(02)00024-0
		CHEMBL354534	127293	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	605	8	0	7	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1	10.1016/s0960-894x(02)00024-0
		44312451	111563	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL310912	111563	0	None	10	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	442	6	0	5	4.5	COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		44312450	211615	0	None	13	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	446	5	0	4	5.2	CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL75448	211615	0	None	13	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	446	5	0	4	5.2	CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		154734599	9281	12	None	1	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
		327	9281	12	None	1	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
		4108	9281	12	None	1	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
		CHEMBL27673	9281	12	None	1	12	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]AF-DX384 from muscarinic M2 receptorDisplacement of [3H]AF-DX384 from muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/np50094a001
		CHEMBL5289667	201254	0	None	-1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	959	21	2	5	13.8	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		156015978	185102	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636899	185102	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651111	185102	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1968	45	8	21	14.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		25006208	119602	0	None	-5	3	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298763	119602	0	None	-5	3	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307197	119602	0	None	-5	3	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	5.0	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cc(Cl)cc(Cl)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		44431384	155639	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL394137	155639	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44344145	17788	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(F)ccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL117414	17788	0	None	-	1	Rat	9.2	pKi	=	9.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	623	7	1	8	4.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cc(F)ccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		56667296	183420	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4461243	183420	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597972	183420	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	472	9	1	4	4.5	O=C(OC1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		10470	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		1689	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		4057	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		CHEMBL524004	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		DB04843	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2014.04.029
		155512178	183268	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4436930	183268	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596672	183268	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	474	8	1	3	4.8	O=C(OC1C[N+]2(CCCc3cccc(F)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		174174	7311	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		260	7311	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		320	7311	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		CHEMBL517712	7311	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		DB00572	7311	49	None	-1	14	Mouse	9.2	pKi	=	9.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00095a008
		174174	7311	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		260	7311	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		320	7311	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		CHEMBL517712	7311	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		DB00572	7311	49	None	-4	14	Rat	9.2	pKi	=	9.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		10393100	63305	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	563	7	0	8	3.1	CCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL163714	63305	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	563	7	0	8	3.1	CCS(=O)(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		44267748	19707	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	516	7	0	5	5.7	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11892	19707	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	516	7	0	5	5.7	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		137628879	167751	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	167751	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	167751	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	167751	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		137628879	167751	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4068393	167751	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4079233	167751	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		CHEMBL4115977	167751	0	None	1	5	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	950	16	3	9	8.1	CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1	10.1021/acs.jmedchem.6b01892
		44324655	174918	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	7	0	8	4.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL433011	174918	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	572	7	0	8	4.5	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44343761	118069	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	638	7	0	7	5.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL326561	118069	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	638	7	0	7	5.7	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		134272452	183453	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4448944	183453	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4598232	183453	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(OC1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		316	9611	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	9611	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	9611	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	9611	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	9611	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	9611	19	None	-6	9	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		11223598	113302	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
		CHEMBL3084413	113302	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
		CHEMBL3140264	113302	0	None	-2	3	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assay	ChEMBL	330	3	0	2	5.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](C=C(c1cccs1)c1cccs1)C2	10.1021/jm900736e
		16125331	143740	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	7	1	1	4.8	C[N+]1(CCCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL374452	143740	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	7	1	1	4.8	C[N+]1(CCCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		122203596	162585	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		174174	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		260	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		320	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		CHEMBL517712	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		DB00572	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00059a009
		174174	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		260	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		320	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		CHEMBL517712	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		DB00572	7311	49	None	-4	14	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00114a005
		122203596	162585	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		16115945	19069	0	None	-9	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1184886	19069	0	None	-9	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL376057	19069	0	None	-9	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		303	9752	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		4629	9752	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		8595	9752	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL44674	9752	17	None	1	6	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		44344132	117137	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL324116	117137	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(N)c6)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		25897919	62426	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		657309	62426	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL1464005	62426	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL1621597	62426	14	None	-4	8	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		9946298	79602	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200171	79602	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		10291366	147477	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL381623	147477	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		25897919	62426	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
		657309	62426	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
		CHEMBL1464005	62426	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
		CHEMBL1621597	62426	14	None	-1	8	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysisDisplacement of [3H]-N-methyl Scopolamine Chloride from human M2 receptor membranes incubated for 2 hrs by scintillation counting analysis	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/acs.jmedchem.1c00204
		122203596	162585	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
		CHEMBL4059733	162585	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
		CHEMBL4066481	162585	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1016/j.ejmech.2021.113159
		156016041	185026	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4644612	185026	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650627	185026	0	None	1	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1238	28	4	13	9.9	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		10291366	147477	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL381623	147477	0	None	-4	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	1	3	3.0	CO[C@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		456615	109523	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL305026	109523	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		44378689	63299	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	611	7	0	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		CHEMBL163658	63299	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	611	7	0	8	4.2	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(S(=O)(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		44378958	16021	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL110744	16021	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	643	6	0	7	5.9	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccc(Cl)c(Cl)c3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		456615	109523	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL305026	109523	1	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44312083	211266	0	None	13	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	5	0	4	4.8	Cc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL72455	211266	0	None	13	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	5	0	4	4.8	Cc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		59291259	119250	1	None	-3	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.6	O=C(Nc1ncsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298591	119250	1	None	-3	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.6	O=C(Nc1ncsc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		174174	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		260	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		320	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		CHEMBL517712	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		DB00572	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		10919522	85693	0	None	-3	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	688	11	1	4	6.8	O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm010480k
		CHEMBL2112957	85693	0	None	-3	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	688	11	1	4	6.8	O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm010480k
		44325017	213636	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	622	8	0	8	5.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL90638	213636	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	622	8	0	8	5.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)SCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		59291413	119564	0	None	-4	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298589	119564	0	None	-4	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305767	119564	0	None	-4	3	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		44325047	214041	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	8	0	8	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL93017	214041	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	590	8	0	8	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		16115947	18621	0	None	-1	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1182214	18621	0	None	-1	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL222259	18621	0	None	-1	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		164620907	195327	0	None	47	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4865939	195327	0	None	47	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028619	195327	0	None	47	5	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		10474247	108181	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		CHEMBL297276	108181	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		44344078	117548	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	636	7	0	7	6.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)SCCS3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL326057	117548	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	636	7	0	7	6.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)SCCS3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9894173	21922	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		CHEMBL12098	21922	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		10163651	170012	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL418446	170012	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1016/j.bmcl.2004.01.033
		9894173	21922	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		CHEMBL12098	21922	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		9894173	21922	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm0255163
		CHEMBL12098	21922	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm0255163
		10163651	170012	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL418446	170012	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		9894173	21922	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm301774u
		CHEMBL12098	21922	4	None	69	5	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	565	6	1	5	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N	10.1021/jm301774u
		15407073	126738	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		CHEMBL349720	126738	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	575	6	0	7	4.6	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		44267782	105296	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL276239	105296	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267782	105296	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
		CHEMBL276239	105296	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
		20689406	118138	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	8	1	8	4.8	CNc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
		CHEMBL326990	118138	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	619	8	1	8	4.8	CNc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)OCCO3)CC2)CC1	10.1016/s0960-894x(02)00742-4
		174174	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		260	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		320	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		CHEMBL517712	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		DB00572	7311	49	None	-7	14	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmcl.2018.12.022
		134272503	183190	0	None	8	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		CHEMBL4545504	183190	0	None	8	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596068	183190	0	None	8	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	9	1	4	4.7	COc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		174174	7311	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	7311	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	7311	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	7311	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	7311	49	None	-7	14	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		10486393	148480	0	None	2	5	Rat	9.0	pKi	=	9.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL1202000	148480	0	None	2	5	Rat	9.0	pKi	=	9.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL385625	148480	0	None	2	5	Rat	9.0	pKi	=	9.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1124	29	4	13	10.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL5270870	200436	0	None	-6	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	507	12	2	4	6.8	NCCCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		164618698	195312	0	None	43	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862098	195312	0	None	43	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028512	195312	0	None	43	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	931	23	10	13	-0.5	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015645	185077	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4638411	185077	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650970	185077	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1158	27	3	11	10.6	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		11691950	19534	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
		CHEMBL1187853	19534	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
		CHEMBL524097	19534	0	None	-2	3	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells coexpressing Gqi5 by scintillation proximity assay	ChEMBL	428	8	1	2	5.4	OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2	10.1021/jm801601v
		16116085	18618	0	None	-9	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1182201	18618	0	None	-9	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL219786	18618	0	None	-9	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		44311786	109827	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL307234	109827	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311786	109827	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL307234	109827	0	None	60	2	Human	9.0	pKi	=	9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	498	6	0	6	4.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		463517	210481	1	None	436	2	Human	9.0	pKi	=	9	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	589	6	0	7	4.8	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL67563	210481	1	None	436	2	Human	9.0	pKi	=	9	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	589	6	0	7	4.8	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		10180872	109906	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL307810	109906	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44378951	64204	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	591	6	1	8	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3O)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL165434	64204	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	591	6	1	8	4.3	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)c3ccccc3O)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		44267696	17803	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ncccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11756	17803	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ncccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44343902	17908	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C(F)(F)F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL117817	17908	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C(F)(F)F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9938599	65487	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL168483	65487	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		174174	7311	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		260	7311	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		320	7311	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		CHEMBL517712	7311	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		DB00572	7311	49	None	-7	14	Human	9.0	pKi	=	9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00041a006
		10180872	109906	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL307810	109906	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	6	0	4	4.9	COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		155522355	183188	0	None	31	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4451030	183188	0	None	31	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4596065	183188	0	None	31	5	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		134272501	183360	0	None	-2	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4483083	183360	0	None	-2	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597500	183360	0	None	-2	2	Human	9.0	pKi	=	9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		44325052	213739	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	562	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL91232	213739	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	562	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		25897919	62426	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		657309	62426	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		CHEMBL1464005	62426	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		CHEMBL1621597	62426	14	None	-1	8	Human	9.0	pKi	=	9.0	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1021/jm900132z
		137630050	167819	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089543	167819	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4097258	167819	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		CHEMBL4116470	167819	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	1358	31	7	15	8.7	CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1	10.1021/acs.jmedchem.6b01892
		127044	85685	1	None	-3	3	Rat	9.0	pKi	=	9.0	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	427	5	1	4	2.9	O=C(OC1CN2CCC1CC2)C(O)(CC=CI)c1ccccc1	10.1021/jm00059a009
		CHEMBL2112942	85685	1	None	-3	3	Rat	9.0	pKi	=	9.0	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	427	5	1	4	2.9	O=C(OC1CN2CCC1CC2)C(O)(CC=CI)c1ccccc1	10.1021/jm00059a009
		16115797	144933	0	None	-3	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL376870	144933	0	None	-3	5	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		155522355	183188	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	183188	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	183188	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		155522355	183188	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	183188	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	183188	0	None	31	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		122203596	162585	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		10437400	201064	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	544	6	2	5	4.5	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5cccc6[nH]ccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL52852	201064	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	544	6	2	5	4.5	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5cccc6[nH]ccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		44344248	120869	0	None	-	1	Rat	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL332702	120869	0	None	-	1	Rat	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	639	7	1	8	5.0	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(Cl)c6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9872651	171893	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	6	0	8	4.8	O=C(Oc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL422740	171893	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	6	0	8	4.8	O=C(Oc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL5289601	201251	0	None	-1	5	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	973	22	2	5	14.1	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		145148382	183393	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		CHEMBL4590868	183393	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597793	183393	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1ccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)cc1	10.1016/j.bmc.2019.06.016
		316	9611	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		317	9611	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		71183	9611	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL3140030	9611	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL376897	9611	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		DB00462	9611	19	None	-6	9	Human	9.0	pKi	=	9.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		44311762	170251	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL420008	170251	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/s0960-894x(00)00457-1
		44311762	170251	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL420008	170251	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	440	6	1	5	4.0	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1	10.1016/j.bmcl.2007.01.058
		5284632	74176	13	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
		CHEMBL1888176	74176	13	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
		CHEMBL3084748	74176	13	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	392	4	1	3	3.8	O=C(O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1	10.1021/acs.jmedchem.9b02100
		316	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		317	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		71183	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL3140030	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		CHEMBL376897	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		DB00462	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.9b02172
		164620270	195321	0	None	50	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4869723	195321	0	None	50	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028587	195321	0	None	50	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44343901	117091	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	620	8	0	8	4.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6OC)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL323850	117091	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	620	8	0	8	4.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6OC)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		59291327	119594	0	None	-3	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL3298597	119594	0	None	-3	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL3307126	119594	0	None	-3	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	344	3	1	4	3.6	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1ccccc1)C2	10.1016/j.bmc.2014.04.031
		59291513	119595	0	None	-4	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL3298598	119595	0	None	-4	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
		CHEMBL3307127	119595	0	None	-4	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	378	3	1	4	4.3	C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ncsc1-c1cccc(Cl)c1)C2	10.1016/j.bmc.2014.04.031
		316	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		317	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		71183	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL3140030	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		CHEMBL376897	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		DB00462	9611	19	None	-6	9	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/acs.jmedchem.6b01892
		44325034	213618	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	634	8	0	9	4.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL90507	213618	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	634	8	0	9	4.1	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		25897919	62426	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
		657309	62426	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
		CHEMBL1464005	62426	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
		CHEMBL1621597	62426	14	None	-1	8	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	10.1016/j.bmcl.2008.03.024
		10275847	210778	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	452	6	0	5	5.2	COc1ccc(S(=O)(=O)c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL69595	210778	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	452	6	0	5	5.2	COc1ccc(S(=O)(=O)c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44378597	64190	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	555	8	0	7	4.5	CCCCC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL165337	64190	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	555	8	0	7	4.5	CCCCC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		44379052	127209	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	539	6	0	7	3.7	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)C3CC3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		CHEMBL353842	127209	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	539	6	0	7	3.7	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCN(C(=O)C3CC3)CC2)C[C@H]1C	10.1016/s0960-894x(02)00024-0
		10119364	50024	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL150624	50024	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		44406481	79650	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200319	79650	0	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		71462570	89341	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	518	5	2	5	5.6	CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O	10.1021/jm300682j
		CHEMBL2178569	89341	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	518	5	2	5	5.6	CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O	10.1021/jm300682j
		44337326	14740	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	600	7	0	5	6.4	COc1ccc(S(=O)(=O)c2ccc(CC3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)cc2)cc1	10.1021/jm0200815
		CHEMBL109051	14740	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	600	7	0	5	6.4	COc1ccc(S(=O)(=O)c2ccc(CC3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)cc2)cc1	10.1021/jm0200815
		174174	7311	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		260	7311	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		320	7311	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		CHEMBL517712	7311	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		DB00572	7311	49	None	-7	14	Human	8.9	pKi	=	8.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	nan
		156015153	185086	0	None	1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4641714	185086	0	None	1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651018	185086	0	None	1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1105	24	2	10	10.3	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		118719922	122553	0	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	565	14	0	7	6.1	CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354068	122553	0	None	-1	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	565	14	0	7	6.1	CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		44343900	17284	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL116781	17284	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	618	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6cccc(C)c6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		59291527	119240	1	None	-11	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1sccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298333	119240	1	None	-11	3	Rat	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1sccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL5281043	200878	0	None	-17	3	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	479	10	2	4	6.1	NCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		155530273	183130	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
		CHEMBL4463636	183130	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
		CHEMBL4595649	183130	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	8	1	3	5.0	Cc1cccc(CCC[N+]23CCC(CC2)C(OC(=O)C(O)(c2ccccc2)c2ccccc2)C3)c1	10.1016/j.bmc.2019.06.016
		156014880	185010	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4636351	185010	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650536	185010	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	1888	44	7	19	15.0	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		174174	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		260	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		320	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		CHEMBL517712	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		DB00572	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1016/j.bmc.2013.01.072
		44311716	171911	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL422770	171911	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311716	171911	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL422770	171911	0	None	22	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	594	9	0	6	5.2	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(S(=O)(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		174174	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		260	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		320	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		CHEMBL517712	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		DB00572	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation countingDisplacement of [3H]NMS from rat recombinant muscarinic M2 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1038/nchembio.2007.55
		16115943	18619	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1182205	18619	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL220393	18619	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	346	3	0	2	4.8	C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		155560140	183126	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4565234	183126	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595575	183126	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		174174	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		260	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		320	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		CHEMBL517712	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		DB00572	7311	49	None	-7	14	Human	8.8	pKi	=	8.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm010480k
		44343735	17862	1	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL117797	17862	1	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	605	7	1	8	4.3	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6N)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		44378807	64924	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	255	4	0	5	2.8	CCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
		CHEMBL167932	64924	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	255	4	0	5	2.8	CCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
		4134	79461	12	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL1996652	79461	12	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2106570	79461	12	None	1	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	342	8	1	3	3.0	CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		10269503	173859	0	None	-7	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL428962	173859	0	None	-7	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		14939896	88862	0	None	-1	3	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201996	88862	0	None	-1	3	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL216566	88862	0	None	-1	3	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		10096939	171599	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]ccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL421864	171599	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]ccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44295932	196124	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51256	196124	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		44344156	16901	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	624	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL115681	16901	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	624	7	0	7	5.4	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9807612	65846	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL169565	65846	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	8	0	8	3.3	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		44383342	66258	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	548	6	0	7	4.4	O=C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL171411	66258	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	548	6	0	7	4.4	O=C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		16065135	74700	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@H](Oc2ccccc2)C1	10.1021/jm200884j
		CHEMBL1910846	74700	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@H](Oc2ccccc2)C1	10.1021/jm200884j
		11693	8608	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		3494	8608	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		4302	8608	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		7459	8608	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		CHEMBL1201335	8608	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		DB00986	8608	16	None	-2	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		140844401	183466	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4539799	183466	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4598363	183466	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3ccc(Br)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		174174	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		260	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		320	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		CHEMBL517712	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		DB00572	7311	49	None	-4	14	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00127a020
		16125541	143985	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL374989	143985	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		155513986	183266	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4439675	183266	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596667	183266	0	None	11	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	19	10	8	1.4	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		101882890	122554	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	593	16	0	7	6.8	CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354069	122554	0	None	-1	5	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	593	16	0	7	6.8	CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		14939894	17068	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL116172	17068	0	None	1	4	Rat	8.8	pKi	=	8.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	742	28	3	8	8.0	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		302	9751	25	None	-3	8	Mouse	8.8	pKi	=	8.8	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		4630	9751	25	None	-3	8	Mouse	8.8	pKi	=	8.8	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		CHEMBL7634	9751	25	None	-3	8	Mouse	8.8	pKi	=	8.8	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		CHEMBL5284000	201018	0	None	-6	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	493	11	2	4	6.6	NCCCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		71128	103585	25	None	-3	8	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
		CHEMBL26505	103585	25	None	-3	8	Rat	8.8	pKi	=	8.8	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00127a020
		14210083	163491	1	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		CHEMBL4070155	163491	1	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		44378763	127281	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	613	6	0	5	6.2	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4cccc(C(F)(F)F)c4)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL354461	127281	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	613	6	0	5	6.2	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4cccc(C(F)(F)F)c4)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44344215	20053	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	668	7	0	7	5.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Br)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL119168	20053	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	668	7	0	7	5.5	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6Br)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		16721019	94761	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234258	94761	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		10061124	85681	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	259	4	0	5	2.3	CN1CCC=C(c2nsnc2SCCF)C1	10.1021/jm00001a002
		CHEMBL2112938	85681	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	259	4	0	5	2.3	CN1CCC=C(c2nsnc2SCCF)C1	10.1021/jm00001a002
		44324891	118341	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@@H](C)[C@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328093	118341	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	600	6	0	9	4.6	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)O[C@@H](C)[C@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		155559741	183066	0	None	5	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4562770	183066	0	None	5	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595125	183066	0	None	5	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		444015	20788	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL1197177	20788	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		44295617	196428	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51510	196428	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1c(N)cccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		44431389	152929	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL391977	152929	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		174174	7311	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		260	7311	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		320	7311	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		CHEMBL517712	7311	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		DB00572	7311	49	None	-7	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm100697g
		59291421	119554	0	None	-2	3	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298592	119554	0	None	-2	3	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305620	119554	0	None	-2	3	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1ncsc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		164609302	195242	0	None	20	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4846958	195242	0	None	20	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5027951	195242	0	None	20	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		14210083	163491	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4070155	163491	1	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
		324	8706	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
		6436265	8706	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
		CHEMBL277642	8706	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(01)00186-x
		324	8706	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		6436265	8706	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		CHEMBL277642	8706	15	None	-1	9	Human	8.0	pKi	=	8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		324	8706	15	None	-1	9	Rat	8.0	pKi	=	8	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
		6436265	8706	15	None	-1	9	Rat	8.0	pKi	=	8	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
		CHEMBL277642	8706	15	None	-1	9	Rat	8.0	pKi	=	8	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00566-8
		10104167	8840	2	None	13	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	8840	2	None	13	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	8840	2	None	13	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		44627746	20814	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197392	20814	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569760	20814	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		122203596	162585	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4059733	162585	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		CHEMBL4066481	162585	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	627	14	3	7	4.3	CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1	10.1021/acs.jmedchem.6b01892
		52941205	62043	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
		CHEMBL1256938	62043	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
		CHEMBL1618160	62043	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	554	27	4	6	7.9	COc1ccccc1NCCCCCCNCCCCCCCCNCCCCCCNc1ccccc1OC	10.1016/j.bmc.2007.09.003
		316	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		317	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		71183	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL3140030	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		CHEMBL376897	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		DB00462	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	10.1021/jm500790x
		156015246	185018	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4648144	185018	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650567	185018	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	406	6	2	4	3.8	NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		71452793	86430	0	None	1	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2115127	86430	0	None	1	4	Human	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		444015	20788	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL1197177	20788	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	304	4	1	3	2.1	C[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		118719921	122552	0	None	-2	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	537	12	0	7	5.3	CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354067	122552	0	None	-2	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	537	12	0	7	5.3	CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		455657	210784	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	624	6	1	8	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(N)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		CHEMBL69642	210784	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	624	6	1	8	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(N)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		455656	210789	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	604	6	1	8	4.5	Cc1cccc(N)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL69670	210789	1	None	-3	2	Human	7.0	pKi	=	7	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	604	6	1	8	4.5	Cc1cccc(N)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		24841480	190678	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL481153	190678	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		135398737	7745	93	None	-22	90	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		38	7745	93	None	-22	90	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		722	7745	93	None	-22	90	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		CHEMBL42	7745	93	None	-22	90	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		DB00363	7745	93	None	-22	90	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		135398745	9688	112	None	-38	65	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		47	9688	112	None	-38	65	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		CHEMBL715	9688	112	None	-38	65	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		DB00334	9688	112	None	-38	65	Human	7.0	pKi	=	7	Binding	Binding affinity to M2 receptor (unknown origin) by PDSP assayBinding affinity to M2 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		44406527	147427	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	CO[C@]1(C#CC(O)(c2cccnc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL381469	147427	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	CO[C@]1(C#CC(O)(c2cccnc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		2551	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		298	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		488	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		CHEMBL965	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		DB00411	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0301235
		46855274	120495	12	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	182	2	0	4	0.3	CN(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323285	120495	12	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	182	2	0	4	0.3	CN(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		155536739	178994	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	384	5	0	4	4.1	COc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
		CHEMBL4473985	178994	0	None	-2	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	384	5	0	4	4.1	COc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
		44385509	67837	11	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	270	4	0	3	1.6	CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O	10.1016/S0960-894X(97)00143-1
		CHEMBL176400	67837	11	None	-3	2	Rat	7.0	pKi	=	7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	270	4	0	3	1.6	CCN(CC)CC#CCN1C(=O)c2ccccc2C1=O	10.1016/S0960-894X(97)00143-1
		2551	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		298	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		488	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		CHEMBL965	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		DB00411	7581	23	None	-6	11	Human	7.0	pKi	=	7	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0606995
		16086067	88092	0	None	-63	5	Human	7.0	pKi	=	7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		CHEMBL215894	88092	0	None	-63	5	Human	7.0	pKi	=	7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		10248403	110197	0	None	-25	2	Rat	6.0	pKi	=	6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	367	6	0	4	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(OC)cc2)cc1	10.1021/jm00020a006
		CHEMBL3084867	110197	0	None	-25	2	Rat	6.0	pKi	=	6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	367	6	0	4	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(OC)cc2)cc1	10.1021/jm00020a006
		44309209	211102	0	None	-38	3	Human	6.0	pKi	=	6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	5	2	3	3.7	CC(C)(N)CC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL71483	211102	0	None	-38	3	Human	6.0	pKi	=	6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	5	2	3	3.7	CC(C)(N)CC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		301	9312	19	None	3	5	Human	6.0	pKi	=	6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		9571002	9312	19	None	3	5	Human	6.0	pKi	=	6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		CHEMBL151938	9312	19	None	3	5	Human	6.0	pKi	=	6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	154	2	0	3	0.9	CO/N=C/C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		118500	163778	63	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4073256	163778	63	None	-1	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	165	4	1	2	1.5	CNCCc1cccc(OC)c1	10.1021/acs.jmedchem.7b01113
		25147647	188918	0	None	2	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@H]21	10.1016/j.bmc.2008.06.025
		CHEMBL478226	188918	0	None	2	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@H]21	10.1016/j.bmc.2008.06.025
		11798126	48746	0	None	-288	3	Human	6.0	pKi	=	6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	2	4	4.1	COc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		CHEMBL149484	48746	0	None	-288	3	Human	6.0	pKi	=	6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	2	4	4.1	COc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		137630848	167895	0	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4061390	167895	0	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117131	167895	0	None	-1	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	213	3	0	3	1.5	C[N+]1(C)CCC(OCc2nccs2)C1	10.1021/acs.jmedchem.7b01113
		302	9751	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		4630	9751	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		CHEMBL7634	9751	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		302	9751	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		4630	9751	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		CHEMBL7634	9751	25	None	-34	8	Human	5.0	pKi	=	5	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		56593934	72469	0	None	-2630	8	Human	5.0	pKi	=	5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
		CHEMBL1834350	72469	0	None	-2630	8	Human	5.0	pKi	=	5	Binding	Inhibition of human muscarinic M2 receptorInhibition of human muscarinic M2 receptor	ChEMBL	383	3	2	4	1.7	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC2(C=N1)CCNCC2	10.1021/jm200466r
		73352414	99307	0	None	-1	5	Human	6.0	pKi	=	6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	257	3	1	1	3.3	C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1	10.1016/j.bmc.2013.07.045
		CHEMBL2432038	99307	0	None	-1	5	Human	6.0	pKi	=	6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	257	3	1	1	3.3	C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1	10.1016/j.bmc.2013.07.045
		16125648	91510	0	None	-44	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2cccnc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222874	91510	0	None	-44	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2cccnc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		15065550	211896	2	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	2	0	3	0.8	Cc1nccn1CC#CCN1CCCC1=O	10.1016/j.bmc.2007.12.036
		CHEMBL77793	211896	2	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	2	0	3	0.8	Cc1nccn1CC#CCN1CCCC1=O	10.1016/j.bmc.2007.12.036
		72064	85176	14	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	10.1016/j.bmc.2013.01.072
		CHEMBL2110892	85176	14	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	10.1016/j.bmc.2013.01.072
		11131099	127039	0	None	3	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		CHEMBL352404	127039	0	None	3	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		302	9751	25	None	-34	8	Human	6.0	pKi	=	6.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		4630	9751	25	None	-34	8	Human	6.0	pKi	=	6.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		CHEMBL7634	9751	25	None	-34	8	Human	6.0	pKi	=	6.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		44593619	194239	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493980	194239	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		73346334	99316	0	None	-1	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	4	1	1	3.0	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)cc1	10.1016/j.bmc.2013.07.045
		CHEMBL2432048	99316	0	None	-1	7	Human	6.0	pKi	=	6.0	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	4	1	1	3.0	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)cc1	10.1016/j.bmc.2013.07.045
		44295616	195572	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	549	6	1	3	6.8	O=C(Nc1ccccc1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL50584	195572	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	549	6	1	3	6.8	O=C(Nc1ccccc1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267766	168098	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		CHEMBL412421	168098	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		44267766	168098	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1021/jm0255163
		CHEMBL412421	168098	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	497	6	1	5	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)C(C)C)cc4)CC3)CC2)c1N	10.1021/jm0255163
		134688371	21201	10	None	-	1	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		13765	21201	10	None	-	1	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		CHEMBL1200623	21201	10	None	-	1	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	nan
		164621085	195328	0	None	16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4869980	195328	0	None	16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028630	195328	0	None	16	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	830	17	8	11	-0.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		639794	105545	1	None	1	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL278129	105545	1	None	1	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		3652	53018	70	None	-2	9	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
		CHEMBL1535	53018	70	None	-2	9	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	nan
		44400175	74543	0	None	-2	2	Rat	7.0	pKi	=	7.0	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	307	5	1	2	4.2	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		CHEMBL190815	74543	0	None	-2	2	Rat	7.0	pKi	=	7.0	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	307	5	1	2	4.2	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		44295878	198569	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	475	5	1	3	5.1	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51982	198569	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	475	5	1	3	5.1	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		71128	103585	25	None	-17	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL26505	103585	25	None	-17	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		16124706	144300	0	None	-61	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	4	5.1	Cc1cccc(CN2CCC(N3CC(c4cccs4)(c4cccs4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL375420	144300	0	None	-61	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	4	5.1	Cc1cccc(CN2CCC(N3CC(c4cccs4)(c4cccs4)NC3=O)CC2)c1	10.1021/jm061159a
		303	9752	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		4629	9752	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		8595	9752	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		CHEMBL44674	9752	17	None	-1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		10871551	127289	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	340	6	0	2	5.2	CCC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL354523	127289	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	340	6	0	2	5.2	CCC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		44593618	194238	0	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493979	194238	0	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		71718669	93733	0	None	-8	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323446	93733	0	None	-8	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		11012712	64603	2	None	1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
		CHEMBL167027	64603	2	None	1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	3	4.2	COc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
		167962	10841	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	10841	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	10841	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		9931930	115377	0	None	-537	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.8	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL320465	115377	0	None	-537	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.8	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		11079969	170636	0	None	-70	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	404	4	1	5	4.3	C=CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL420662	170636	0	None	-70	5	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	404	4	1	5	4.3	C=CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		44267713	22377	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	466	7	0	4	5.8	COc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12215	22377	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	466	7	0	4	5.8	COc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		16125400	91438	0	None	-35	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222449	91438	0	None	-35	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	494	6	1	2	4.5	C[N+]1(CC(=O)c2cccc(F)c2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		71456286	86373	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL2114430	86373	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		10380647	161213	1	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	309	2	0	2	4.8	c1ccc(CN2CCC3(CCc4ccccc4S3)CC2)cc1	10.1021/jm970740r
		CHEMBL39900	161213	1	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	309	2	0	2	4.8	c1ccc(CN2CCC3(CCc4ccccc4S3)CC2)cc1	10.1021/jm970740r
		15050949	210755	0	None	1	3	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	641	10	3	8	4.2	CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		CHEMBL69458	210755	0	None	1	3	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	641	10	3	8	4.2	CC(C)(C)OC(=O)NCCCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		11498	9793	41	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
		4995951	9793	41	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
		CHEMBL59898	9793	41	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1016/j.bmcl.2008.03.061
		15888011	211092	0	None	-11	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	302	3	2	3	2.0	NC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL71431	211092	0	None	-11	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	302	3	2	3	2.0	NC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		44267718	23785	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4nccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12542	23785	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4nccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL5285607	201083	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1052	21	1	13	10.0	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
		155521383	183205	0	None	8	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4450522	183205	0	None	8	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596184	183205	0	None	8	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	604	13	6	6	2.7	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		71741394	127613	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323287	127613	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558239	127613	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		10474247	108181	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		CHEMBL297276	108181	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		15678852	108994	0	None	1	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	492	12	2	6	4.0	NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL302923	108994	0	None	1	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	492	12	2	6	4.0	NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		3652	10869	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		57	10869	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		60809	10869	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		CHEMBL21536	10869	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		DB15357	10869	79	None	-18	18	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		2028	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		359	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		4634	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		CHEMBL1231	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		DB01062	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm2013216
		14964495	19385	1	None	4	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118700	19385	1	None	4	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		11526446	208583	0	None	-13	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccsc1	10.1021/jm050099q
		CHEMBL606904	208583	0	None	-13	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccsc1	10.1021/jm050099q
		16086064	86735	0	None	-213	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	10	2	5	5.6	O=C(NCC1CCN(C2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL212645	86735	0	None	-213	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	10	2	5	5.6	O=C(NCC1CCN(C2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		5747382	115980	3	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL321605	115980	3	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		44309208	172428	0	None	-77	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.1	O=C(N1CCCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL424416	172428	0	None	-77	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.1	O=C(N1CCCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		14964496	15736	0	None	1	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL109815	15736	0	None	1	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		10339062	43061	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	1	3.4	C[N+]12CCC(CC1)C(c1cc3ccccc3o1)C2	10.1021/jm00003a011
		CHEMBL144580	43061	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	1	3.4	C[N+]12CCC(CC1)C(c1cc3ccccc3o1)C2	10.1021/jm00003a011
		474188	38423	2	None	-28	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	1	6	4.5	Cc1nc(N)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL140490	38423	2	None	-28	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	1	6	4.5	Cc1nc(N)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10595006	18217	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL1180343	18217	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL123099	18217	0	None	-6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	365	7	0	4	4.0	CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		53414666	166080	8	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4099673	166080	8	None	1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	4	1	3	1.2	c1cncc(COCC2CCNC2)c1	10.1021/acs.jmedchem.7b01113
		574782	108928	2	None	-3	3	Rat	5.0	pKi	=	5.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	397	3	1	6	2.3	CSc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCN(C)CC1	10.1021/jm00111a032
		CHEMBL302557	108928	2	None	-3	3	Rat	5.0	pKi	=	5.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	397	3	1	6	2.3	CSc1ccc2c(c1)C(=O)Nc1cccnc1N2C(=O)CN1CCN(C)CC1	10.1021/jm00111a032
		2274	9947	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	9947	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	9947	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	9947	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	9947	58	None	-100	31	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		44379508	64938	0	None	-3	3	Human	7.0	pKi	=	7.0	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	664	9	1	4	6.6	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1cccc(I)c1	10.1016/S0960-894X(97)00109-1
		CHEMBL168145	64938	0	None	-3	3	Human	7.0	pKi	=	7.0	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	664	9	1	4	6.6	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1cccc(I)c1	10.1016/S0960-894X(97)00109-1
		11034265	127151	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	310	5	0	2	4.3	CC(C1=C(CCN(C)C)Cc2ccc(F)cc21)c1ccccn1	10.1021/jm020895l
		CHEMBL353290	127151	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	310	5	0	2	4.3	CC(C1=C(CCN(C)C)Cc2ccc(F)cc21)c1ccccn1	10.1021/jm020895l
		162353386	187759	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4758635	187759	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	C[C@H]1CCC[C@@H](C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		46227555	20903	1	None	5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL1198062	20903	1	None	5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL594376	20903	1	None	5	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		44443734	101014	0	None	-16	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL250031	101014	0	None	-16	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		36014865	189449	2	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
		CHEMBL4789054	189449	2	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	280	4	1	2	3.5	O=C(CCN1CCCc2ccccc21)Nc1ccccc1	10.1016/j.bmcl.2020.127632
		16125682	91064	0	None	-239	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	465	5	1	2	5.0	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		CHEMBL221401	91064	0	None	-239	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	465	5	1	2	5.0	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		44299635	107345	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL291562	107345	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		164623185	195349	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4864101	195349	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028743	195349	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	407	4	3	5	1.5	NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		137640511	163845	0	None	-44	8	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	286	4	0	2	3.1	CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4074104	163845	0	None	-44	8	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	286	4	0	2	3.1	CC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		16125593	91516	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	467	8	1	3	4.1	N#CC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222916	91516	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	467	8	1	3	4.1	N#CC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		3198	212292	76	None	-16	34	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	212292	76	None	-16	34	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	212292	76	None	-16	34	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		73345823	96590	0	None	-19	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	305	10	0	3	4.1	CC[C@H](C)C(C(=O)OCCCN(CC)CC)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377392	96590	0	None	-19	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	305	10	0	3	4.1	CC[C@H](C)C(C(=O)OCCCN(CC)CC)c1ccccc1	10.1016/j.bmc.2013.01.072
		11722587	19708	0	None	-5	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1189204	19708	0	None	-5	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL538266	19708	0	None	-5	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	304	7	1	4	3.0	CCN(CC)CCOC(=O)C1(c2ccc(N)cc2)CCCC1	10.1021/jm00114a005
		26987	7736	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		6063	7736	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		671	7736	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		CHEMBL1626	7736	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		DB00283	7736	33	None	-102	21	Human	6.9	pKi	=	6.9	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41586-020-2286-9
		71575447	92977	0	None	-19	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	363	5	0	4	3.5	CN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
		CHEMBL2312361	92977	0	None	-19	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	363	5	0	4	3.5	CN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
		44299599	174584	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL430587	174584	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		44313166	109878	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	415	7	0	5	4.0	O=C(OCOCCN1CCOCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		CHEMBL307628	109878	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	415	7	0	5	4.0	O=C(OCOCCN1CCOCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		2337	10030	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	10030	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	10030	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	10030	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	10030	77	None	-31	62	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		11061341	85694	0	None	-25	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	662	13	2	4	6.3	O=C(CCNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112958	85694	0	None	-25	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	662	13	2	4	6.3	O=C(CCNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		44295787	195865	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	481	6	1	3	5.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL50998	195865	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	481	6	1	3	5.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267759	18522	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	529	7	0	4	5.6	CN(C)C(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11816	18522	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	529	7	0	4	5.6	CN(C)C(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		10163651	170012	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL418446	170012	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		15870389	127572	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2cccnc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL355510	127572	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	599	6	0	8	4.9	O=C(c1cccc2cccnc12)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		277	8083	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	8083	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	8083	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	8083	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	8083	62	None	-12	50	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2286	9957	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	9957	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	9957	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	9957	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	9957	51	None	-3	30	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		2745	10633	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		5572	10633	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		66007	10633	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		7315	10633	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		CHEMBL1490	10633	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		DB00376	10633	42	None	-46	9	Human	7.9	pKi	=	7.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	nan
		44431388	94094	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL233202	94094	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44431380	94760	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234257	94760	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		16065136	74701	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@@H](Oc2ccccc2)C1	10.1021/jm200884j
		CHEMBL1910847	74701	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	442	9	1	3	5.2	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC[C@@H](Oc2ccccc2)C1	10.1021/jm200884j
		140844418	183189	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4576060	183189	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596067	183189	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.9	O=C(OC1C[N+]2(CCCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		140844397	183377	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4567385	183377	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597612	183377	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	486	10	1	4	4.7	O=C(OC1C[N+]2(CCCOCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		140844405	183421	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4474694	183421	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597973	183421	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	470	9	1	3	5.1	O=C(OC1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		10316726	18800	0	None	-35	5	Rat	7.9	pKi	=	7.9	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		CHEMBL1183364	18800	0	None	-35	5	Rat	7.9	pKi	=	7.9	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		CHEMBL292857	18800	0	None	-35	5	Rat	7.9	pKi	=	7.9	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		164614994	195281	0	None	23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4850553	195281	0	None	23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028287	195281	0	None	23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	930	23	9	12	0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		155528270	183170	0	None	7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4461081	183170	0	None	7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595943	183170	0	None	7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		44325080	118348	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	588	8	0	7	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328120	118348	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	588	8	0	7	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44392966	72873	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3C(CCC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL183903	72873	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3C(CCC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		11808040	175174	0	None	2	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL434684	175174	0	None	2	6	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	4	0	2	3.8	CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		75167447	185065	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4634230	185065	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650933	185065	0	None	-23	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		44233190	110179	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084679	110179	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	335	5	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		324	8706	15	None	-1	9	Rat	7.9	pKi	=	7.9	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
		6436265	8706	15	None	-1	9	Rat	7.9	pKi	=	7.9	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
		CHEMBL277642	8706	15	None	-1	9	Rat	7.9	pKi	=	7.9	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00695-9
		154417	100035	60	None	-18	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	100035	60	None	-18	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		10418181	16358	1	None	-5	4	Rat	7.9	pKi	=	7.9	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL112500	16358	1	None	-5	4	Rat	7.9	pKi	=	7.9	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201995	16358	1	None	-5	4	Rat	7.9	pKi	=	7.9	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	26	3	10	8.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		205895	18640	2	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		CHEMBL118240	18640	2	None	1	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		154059	10409	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		2457	10409	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		7483	10409	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		CHEMBL1734	10409	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		DB01591	10409	51	None	-3	8	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1021/jm050099q
		3652	10869	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		57	10869	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		60809	10869	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		CHEMBL21536	10869	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		DB15357	10869	79	None	-18	18	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm100697g
		155515662	176743	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	336	4	0	3	3.9	O=C(OCc1ccccc1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		CHEMBL4441786	176743	0	None	-1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	336	4	0	3	3.9	O=C(OCc1ccccc1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		2200	9905	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		328	9905	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		4848	9905	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		CHEMBL9967	9905	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		DB00670	9905	46	None	-31	13	Rat	6.9	pKi	=	6.9	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00127a020
		154059	10409	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		2457	10409	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		7483	10409	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		CHEMBL1734	10409	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		DB01591	10409	51	None	-12	8	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	10.1016/j.ejmech.2017.06.004
		44308910	210521	0	None	-39	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	324	3	2	3	1.7	O=C(N1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL67814	210521	0	None	-39	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	324	3	2	3	1.7	O=C(N1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		9794266	163930	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	205	2	0	2	2.1	COc1cccc2c1CC(N(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4075227	163930	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	205	2	0	2	2.1	COc1cccc2c1CC(N(C)C)CC2	10.1021/acs.jmedchem.7b01113
		44318817	175893	0	None	-7	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		CHEMBL440138	175893	0	None	-7	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		16086065	86572	0	None	-426	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	622	10	3	5	3.9	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		CHEMBL211976	86572	0	None	-426	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	622	10	3	5	3.9	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		3072501	114046	6	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL316973	114046	6	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		5747382	115980	3	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL321605	115980	3	None	-	1	Mouse	4.9	pKi	=	4.9	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	410	11	3	10	2.8	CN(C)Cc1ccc(CSCCNc2cc(NN)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		71716224	93731	0	None	-13	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323444	93731	0	None	-13	3	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		71451002	86485	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
		CHEMBL2115494	86485	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
		71451002	86485	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
		CHEMBL2115494	86485	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	185	1	2	4	-0.3	COC(=O)[C@H]1CC2NC1CC[C@@H]2O	10.1021/jm9705115
		657347	11848	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL105457	11848	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL387632	11848	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		72190449	99047	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426676	99047	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		657347	11848	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		CHEMBL105457	11848	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		CHEMBL387632	11848	2	None	-10	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.5	C[C@H]1OC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		44274302	83842	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL20732	83842	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		2166	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		305	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		5910	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		CHEMBL550	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		DB01085	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/j.bmc.2007.12.036
		44448419	19108	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185266	19108	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL403592	19108	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	580	16	2	2	7.0	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CCC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		44295713	196527	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	495	6	1	3	5.8	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)Nc4ccccc4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51588	196527	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	495	6	1	3	5.8	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)Nc4ccccc4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		71459604	90568	0	None	-2	14	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205811	90568	0	None	-2	14	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
		463319	126174	1	None	-102	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	579	5	0	5	6.5	Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL344607	126174	1	None	-102	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	579	5	0	5	6.5	Cc1nc(-c2ccccc2)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		1971	9641	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	9641	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	9641	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	9641	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	9641	38	None	-9	30	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		14967772	20185	7	None	-58	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1192807	20185	7	None	-58	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL544107	20185	7	None	-58	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	415	7	0	3	4.0	CCN(CC)CCOC(=O)C1(c2ccc(I)cc2)CCCC1	10.1021/jm00114a005
		688567	69808	4	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		CHEMBL1788199	69808	4	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		10251468	100844	0	None	-20	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.2	Cc1ccc(C(C)N2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
		CHEMBL249006	100844	0	None	-20	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.2	Cc1ccc(C(C)N2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
		2551	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		298	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		488	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		CHEMBL965	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		DB00411	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm0510878
		12963076	203404	4	None	-2951	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL564226	203404	4	None	-2951	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		109018479	188597	1	None	2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
		CHEMBL4778178	188597	1	None	2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	5	1	3	2.7	O=C(CCN1CCCc2ccccc21)NCc1ccco1	10.1016/j.bmcl.2020.127632
		2551	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		298	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		488	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		CHEMBL965	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		DB00411	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		2551	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		298	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		488	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		CHEMBL965	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		DB00411	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm800145d
		2551	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		298	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		488	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL965	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		DB00411	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2009.10.027
		2551	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		298	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		488	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		CHEMBL965	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		DB00411	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2014.06.020
		145961125	168325	0	None	-3	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4128667	168325	0	None	-3	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		71463063	90576	0	None	-2	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205825	90576	0	None	-2	8	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		44318928	212542	0	None	-28	2	Human	6.9	pKi	=	6.9	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
		CHEMBL82859	212542	0	None	-28	2	Human	6.9	pKi	=	6.9	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	400	6	0	3	5.0	COc1ccc(N(C(=O)c2ccccc2)C2CCN(Cc3ccccc3)CC2)cc1	10.1016/s0960-894x(02)00487-0
		250	10159	8	None	-35481	13	Human	5.9	pKi	=	5.9	Binding	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		5311416	10159	8	None	-35481	13	Human	5.9	pKi	=	5.9	Binding	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		CHEMBL69733	10159	8	None	-35481	13	Human	5.9	pKi	=	5.9	Binding	Compound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assayCompound was evaluated for binding affinity against Muscarinic M2 receptor using radioligand binding assay	ChEMBL	502	10	1	7	5.0	COc1cc(CCCN2CCC(CC2)CCC(=O)c2cc(Cl)c(c3c2OCCO3)N)ccc1OC	10.1016/0960-894X(95)00358-Z
		24865895	102780	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL259662	102780	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL390842	102780	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		44274469	87383	1	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21509	87383	1	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		44406321	79553	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	415	3	1	3	4.3	CO[C@]1(C#CC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL199981	79553	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	415	3	1	3	4.3	CO[C@]1(C#CC(O)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		6918276	22383	7	None	-131	8	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	22383	7	None	-131	8	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		60138186	127614	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	127614	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	127614	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	127614	0	None	23	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		44267712	168802	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	515	7	1	5	4.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(S(N)(=O)=O)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL415975	168802	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	515	7	1	5	4.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(S(N)(=O)=O)cc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		1548953	214458	27	None	-6	17	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	214458	27	None	-6	17	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		71452387	90578	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2012.08.046
		CHEMBL2205829	90578	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmcl.2012.08.046
		71452387	90578	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmc.2013.07.045
		CHEMBL2205829	90578	0	None	1	7	Human	5.9	pKi	=	5.9	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	309	2	1	4	1.7	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2	10.1016/j.bmc.2013.07.045
		11006792	85697	0	None	-5	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	648	12	2	4	5.9	O=C(CNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112961	85697	0	None	-5	5	Human	7.9	pKi	=	7.9	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	648	12	2	4	5.9	O=C(CNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		11501540	140381	0	None	-16	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
		CHEMBL371293	140381	0	None	-16	3	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
		44406598	79800	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200957	79800	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	3	1	3	2.8	COC1(C#CC(O)(c2ccccc2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44383238	127405	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	387	4	0	3	5.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC4CCCCC43)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL354636	127405	0	None	2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	387	4	0	3	5.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC4CCCCC43)[C@@H]12	10.1016/s0960-894x(99)00101-8
		59291452	119553	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298590	119553	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305615	119553	0	None	-3	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.1	O=C(Nc1ccsc1-c1ccccc1)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL5279174	200795	0	None	-16	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	474	9	1	3	6.7	C#CCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		155541812	179829	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	5	0	3	4.1	O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1	10.1016/j.bmcl.2018.12.022
		CHEMBL4519301	179829	0	None	-7	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	5	0	3	4.1	O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1	10.1016/j.bmcl.2018.12.022
		164623942	195358	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4873621	195358	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028796	195358	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	831	21	11	10	0.9	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		156020548	184957	0	None	-9	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4649224	184957	0	None	-9	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		10759971	72027	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL182761	72027	0	None	5	2	Human	7.9	pKi	=	7.9	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		44627748	20866	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL1197705	20866	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL583027	20866	0	None	-1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	332	4	0	1	5.4	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		15050960	109104	0	None	-4	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	548	15	1	6	5.4	CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL303622	109104	0	None	-4	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	548	15	1	6	5.4	CCN(CC)CCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		2381	7450	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		374	7450	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		7128	7450	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		CHEMBL1101	7450	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		DB00810	7450	48	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	10.1016/j.bmc.2013.01.072
		156021441	184933	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648939	184933	0	None	-2	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		44308912	109610	0	None	-61	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	2	3	2.1	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL305531	109610	0	None	-61	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	2	3	2.1	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)C1	10.1016/s0960-894x(03)00350-0
		155562285	182621	0	None	-16	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	6	0	4	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1	10.1016/j.bmcl.2018.12.022
		CHEMBL4585326	182621	0	None	-16	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	6	0	4	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1	10.1016/j.bmcl.2018.12.022
		44296044	201449	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	555	6	1	3	6.6	O=C(NC1CCCCC1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL53190	201449	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	555	6	1	3	6.6	O=C(NC1CCCCC1)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		14964499	176168	3	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL442206	176168	3	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		15196354	126048	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
		CHEMBL343697	126048	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
		2551	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		298	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		488	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		CHEMBL965	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		DB00411	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm020572p
		137630994	167919	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4103375	167919	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4117267	167919	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CC(C[N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		10421982	212820	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
		CHEMBL85190	212820	0	None	1	4	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
		16086061	86993	0	None	-1412	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	690	10	2	5	4.6	CCN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
		CHEMBL213709	86993	0	None	-1412	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	690	10	2	5	4.6	CCN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
		10597259	126035	0	None	-67	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](F)C2)CC1	10.1021/jm0003135
		CHEMBL343644	126035	0	None	-67	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](F)C2)CC1	10.1021/jm0003135
		14964499	176168	3	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL442206	176168	3	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		14964506	120093	1	None	-6	2	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL331556	120093	1	None	-6	2	Rat	4.9	pKi	=	4.9	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		137629935	167799	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	167799	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	167799	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		118710670	127611	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	127611	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	127611	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		2551	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		298	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		488	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		CHEMBL965	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		DB00411	7581	23	None	-6	11	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1016/j.bmc.2007.12.036
		164612852	195262	0	None	9	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4852544	195262	0	None	9	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028161	195262	0	None	9	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		164627387	195385	0	None	7	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4874785	195385	0	None	7	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028995	195385	0	None	7	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		162353369	187574	0	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
		CHEMBL4756442	187574	0	None	1	4	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC(O)CC1	10.1016/j.bmcl.2020.127632
		19021478	199476	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constantBinding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constant	ChEMBL	356	4	1	3	4.5	CNC(=O)Oc1cccc2c1CCC1C2CCN1CCC1CCCCC1	10.1016/j.ejmech.2022.114606
		CHEMBL5219452	199476	0	None	5	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constantBinding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constant	ChEMBL	356	4	1	3	4.5	CNC(=O)Oc1cccc2c1CCC1C2CCN1CCC1CCCCC1	10.1016/j.ejmech.2022.114606
		3497	7964	25	None	-47	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
		5311123	7964	25	None	-47	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
		CHEMBL1628706	7964	25	None	-47	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	482	11	4	6	2.5	O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C	10.1021/jm300682j
		457875	12001	1	None	-22	3	Human	5.9	pKi	=	5.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	482	4	0	2	6.0	Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Cc3ccc(Br)cc3)CC2)CC1	10.1021/jm0200815
		CHEMBL106247	12001	1	None	-22	3	Human	5.9	pKi	=	5.9	Binding	Inhibitory activity against Muscarinic acetylcholine receptor M2Inhibitory activity against Muscarinic acetylcholine receptor M2	ChEMBL	482	4	0	2	6.0	Cc1cccc(C)c1C(=O)N1CCC(C)(N2CCC(Cc3ccc(Br)cc3)CC2)CC1	10.1021/jm0200815
		44267754	22025	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.1	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12115	22025	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.1	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(Cl)cc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267714	104150	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	427	6	0	5	4.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccno4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL269645	104150	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	427	6	0	5	4.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccno4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		4601	213526	35	None	-2	17	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL1201023	213526	35	None	-2	17	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		CHEMBL900	213526	35	None	-2	17	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
		73350398	96573	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	363	8	0	4	5.0	CCN(CC)CCOC(=O)c1ccccc1Sc1ccc(Cl)cc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377262	96573	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	363	8	0	4	5.0	CCN(CC)CCOC(=O)c1ccccc1Sc1ccc(Cl)cc1	10.1016/j.bmc.2013.01.072
		15678859	109552	0	None	-1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	436	8	2	6	2.4	NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL305197	109552	0	None	-1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	436	8	2	6	2.4	NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		71463061	90570	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
		CHEMBL2205813	90570	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
		156015968	185024	0	None	-2	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648657	185024	0	None	-2	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650620	185024	0	None	-2	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		10874119	11679	0	None	-18	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	454	4	1	5	5.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OCc5ccccc5)c34)OC21	10.1021/jm011116o
		CHEMBL104574	11679	0	None	-18	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	454	4	1	5	5.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OCc5ccccc5)c34)OC21	10.1021/jm011116o
		10862395	11798	0	None	-338	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	4	1	5	4.4	CCOC(=O)c1c(CC)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL105148	11798	0	None	-338	5	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	4	1	5	4.4	CCOC(=O)c1c(CC)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		44312468	211366	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	402	5	0	5	3.4	CCOC(=O)N1CCN(C(C)c2ccc(S(=O)(=O)c3ccccc3)cc2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL73145	211366	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	402	5	0	5	3.4	CCOC(=O)N1CCN(C(C)c2ccc(S(=O)(=O)c3ccccc3)cc2)CC1	10.1016/s0960-894x(00)00438-8
		44443732	101013	0	None	-41	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL250030	101013	0	None	-41	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		15050940	109604	0	None	1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	375	3	1	5	1.6	C#CCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL305501	109604	0	None	1	2	Rat	5.9	pKi	=	5.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	375	3	1	5	1.6	C#CCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		13773338	86364	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2114395	86364	0	None	-	1	Rat	4.9	pKi	=	4.9	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		13773338	86364	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2114395	86364	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		44382125	127194	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	9	0	7	3.6	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL353689	127194	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	9	0	7	3.6	CCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		164617650	195300	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4860171	195300	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028445	195300	0	None	5	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	676	13	8	9	-0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		156014875	185020	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4640846	185020	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650577	185020	0	None	1	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		46227413	20912	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL1198087	20912	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL595265	20912	0	None	-1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@H]1C	10.1016/j.bmc.2009.10.027
		44267728	21519	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	4	7.3	CCOc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
		CHEMBL12064	21519	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	4	7.3	CCOc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
		2028	9753	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		359	9753	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		4634	9753	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		CHEMBL1231	9753	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		DB01062	9753	80	None	-5	11	Rat	7.9	pKi	=	7.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1021/jm050099q
		44382652	65800	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	7	0	8	3.3	CC(C)S(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL169313	65800	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	550	7	0	8	3.3	CC(C)S(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		90645361	119593	0	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298601	119593	0	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3307123	119593	0	None	-7	3	Rat	7.9	pKi	=	7.9	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	412	3	1	4	4.8	C[N+]12CCC(OC(=O)Nc3ncsc3-c3cccc(C(F)(F)F)c3)(CC1)CC2	10.1016/j.bmc.2014.04.031
		10373706	64183	0	None	-2	4	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	959	31	2	10	10.2	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
		CHEMBL165220	64183	0	None	-2	4	Rat	7.9	pKi	=	7.9	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	959	31	2	10	10.2	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
		154734599	9281	12	None	1	12	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
		327	9281	12	None	1	12	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
		4108	9281	12	None	1	12	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
		CHEMBL27673	9281	12	None	1	12	Human	7.8	pKi	=	7.8	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm0155594
		44324848	213559	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	7	0	8	5.9	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL90199	213559	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	7	0	8	5.9	CCOC(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc(OC)cc5)cc4)SCCCS3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		154734599	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
		327	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
		4108	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
		CHEMBL27673	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00075a032
		71741394	127613	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323287	127613	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558239	127613	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		154734599	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
		327	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
		4108	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
		CHEMBL27673	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/0960-894X(95)00113-8
		154734599	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
		327	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
		4108	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
		CHEMBL27673	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm00046a021
		164611187	195249	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4851265	195249	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028060	195249	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	732	17	8	9	1.3	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		6338102	107241	1	None	20	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL290723	107241	1	None	20	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL59587	107241	1	None	20	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		11552283	78465	0	None	-15	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	3	0	4	3.8	O=C(O[C@H]1CN2CCC1CC2)C1CCc2ccccc2N1c1ccccc1	10.1021/jm050099q
		CHEMBL196481	78465	0	None	-15	3	Rat	6.9	pKi	=	6.9	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	3	0	4	3.8	O=C(O[C@H]1CN2CCC1CC2)C1CCc2ccccc2N1c1ccccc1	10.1021/jm050099q
		137630667	167871	0	None	-6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4100938	167871	0	None	-6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116890	167871	0	None	-6	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	3	0	1	2.7	C[N+](C)(C)CCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		11796409	45165	0	None	-89	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
		CHEMBL146351	45165	0	None	-89	3	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
		155515982	176789	0	None	-56234	17	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4442460	176789	0	None	-56234	17	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		170332	167755	1	None	3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	167755	1	None	3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	167755	1	None	3	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		137629919	167788	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4095626	167788	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116258	167788	0	None	1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	234	3	0	1	2.5	COc1cccc2c1CCC(C[N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		10386	167947	16	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4092348	167947	16	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117554	167947	16	None	-1	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	180	3	1	1	1.6	C[N+](C)(C)CCc1cccc(O)c1	10.1021/acs.jmedchem.7b01113
		10810094	126338	0	None	-52	3	Human	4.9	pKi	=	4.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	6	2	3	3.8	O=C(NC1CCN(CC2CCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL345985	126338	0	None	-52	3	Human	4.9	pKi	=	4.9	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	6	2	3	3.8	O=C(NC1CCN(CC2CCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		9976808	110219	0	None	-11	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
		CHEMBL3084892	110219	0	None	-11	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
		156015895	185060	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4643290	185060	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650874	185060	0	None	1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	993	21	2	8	10.7	CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21	10.1021/acs.jmedchem.9b02172
		44627742	205156	0	None	-10	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	323	4	0	2	5.8	CN1CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL576707	205156	0	None	-10	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	323	4	0	2	5.8	CN1CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		44593623	194659	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496503	194659	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539373	194659	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		44450622	102608	0	None	4	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL258907	102608	0	None	4	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		167962	10841	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	10841	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	10841	4	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		44274432	86902	0	None	3	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21328	86902	0	None	3	5	Human	4.9	pKi	=	4.9	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		58438475	99048	0	None	-1548	2	Human	4.9	pKi	=	4.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426677	99048	0	None	-1548	2	Human	4.9	pKi	=	4.9	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		24894635	176586	0	None	1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
		CHEMBL443939	176586	0	None	1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
		CHEMBL527880	176586	0	None	1	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@@H]1c1ccco1	10.1021/jm800145d
		44443721	101037	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	390	6	2	3	3.3	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL250203	101037	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	390	6	2	3	3.3	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		11012653	127598	0	None	6	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	6	0	2	4.9	CC(C1=C(CCN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL355769	127598	0	None	6	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	6	0	2	4.9	CC(C1=C(CCN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		164617938	195305	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4854179	195305	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028470	195305	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		10969696	138883	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	334	5	0	3	3.9	CC(C1=C(CCN2CCOCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL369575	138883	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	334	5	0	3	3.9	CC(C1=C(CCN2CCOCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		44593621	200076	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524061	200076	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		10160219	11702	0	None	-1445	5	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	436	5	1	5	5.5	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		CHEMBL104693	11702	0	None	-1445	5	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	436	5	1	5	5.5	CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		72190451	99051	0	None	-524	2	Human	4.8	pKi	=	4.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426680	99051	0	None	-524	2	Human	4.8	pKi	=	4.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		24894632	196198	2	None	1	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc(C2CCCN2C)o1	10.1021/jm800145d
		CHEMBL513277	196198	2	None	1	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc(C2CCCN2C)o1	10.1021/jm800145d
		10020614	211546	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	347	10	0	4	3.8	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCCC1	10.1021/jm00041a006
		CHEMBL74736	211546	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	347	10	0	4	3.8	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCCC1	10.1021/jm00041a006
		13773342	86457	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2115341	86457	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		302	9751	25	None	-34	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		4630	9751	25	None	-34	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		CHEMBL7634	9751	25	None	-34	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.6b01892
		CHEMBL4520788	220754	10	None	-69	25	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a CHRM2Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a CHRM2	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		10870954	127088	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL352779	127088	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		44384327	66563	0	None	10	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	349	4	1	4	3.2	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(O)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL172646	66563	0	None	10	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	349	4	1	4	3.2	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(O)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		71457690	90573	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205817	90573	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1cccnc1	10.1016/j.bmcl.2012.08.046
		9976807	110212	1	None	-36	3	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL3084884	110212	1	None	-36	3	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		71455894	90577	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
		CHEMBL2205827	90577	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmcl.2012.08.046
		71455894	90577	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
		CHEMBL2205827	90577	0	None	-1	12	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	4	1	4	2.0	COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC	10.1016/j.bmc.2013.07.045
		10336462	110211	0	None	-13	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	325	4	0	2	4.6	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
		CHEMBL3084883	110211	0	None	-13	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	325	4	0	2	4.6	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
		44295789	196217	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	501	6	1	3	5.6	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC4CCCCC4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL51339	196217	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	501	6	1	3	5.6	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC4CCCCC4)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		14964496	15736	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL109815	15736	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		11561621	208582	0	None	-15	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccsc1	10.1021/jm050099q
		CHEMBL606903	208582	0	None	-15	3	Rat	7.8	pKi	=	7.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccsc1	10.1021/jm050099q
		9894922	127072	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	8	0	8	4.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)Cc4ccccc4)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
		CHEMBL352660	127072	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	598	8	0	8	4.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)Cc4ccccc4)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
		154734599	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
		327	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
		4108	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
		CHEMBL27673	9281	12	None	-1	12	Rat	7.8	pKi	=	7.8	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm970740r
		54757332	74699	0	None	-7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	414	9	1	3	4.4	NC(=O)C(CCCN1CC[C@H](Oc2ccccc2)C1)(c1ccccc1)c1ccccc1	10.1021/jm200884j
		CHEMBL1910845	74699	0	None	-7	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	414	9	1	3	4.4	NC(=O)C(CCCN1CC[C@H](Oc2ccccc2)C1)(c1ccccc1)c1ccccc1	10.1021/jm200884j
		410345	96578	4	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	333	8	1	4	3.4	CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1	10.1016/j.bmc.2013.01.072
		CHEMBL2377269	96578	4	None	-1	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	333	8	1	4	3.4	CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1	10.1016/j.bmc.2013.01.072
		11748799	172190	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.3	CN(C)CCC1=C(C(C)(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL423831	172190	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.3	CN(C)CCC1=C(C(C)(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		10226457	19747	0	None	-3	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL1189471	19747	0	None	-3	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL538793	19747	0	None	-3	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	423	15	0	7	5.1	CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		9909908	20291	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
		CHEMBL1193635	20291	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
		CHEMBL545077	20291	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	381	14	1	6	4.5	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1	10.1021/jm0301235
		11071537	33269	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	495	17	0	10	5.5	COc1nsnc1OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL136027	33269	0	None	1	5	Human	7.8	pKi	=	7.8	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	495	17	0	10	5.5	COc1nsnc1OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		174174	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		260	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		320	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		CHEMBL517712	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		DB00572	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		302	9751	25	None	-3	8	Mouse	5.8	pKi	=	5.8	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		4630	9751	25	None	-3	8	Mouse	5.8	pKi	=	5.8	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		CHEMBL7634	9751	25	None	-3	8	Mouse	5.8	pKi	=	5.8	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00095a008
		44267695	17496	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	502	7	1	4	5.6	O=C(O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11710	17496	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	502	7	1	4	5.6	O=C(O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		14964507	121132	1	None	-5	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL333107	121132	1	None	-5	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		303	9752	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		4629	9752	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		8595	9752	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL44674	9752	17	None	1	6	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		14685523	44528	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	177	1	0	2	2.1	c1coc(C2CN3CCC2CC3)c1	10.1021/jm00003a011
		CHEMBL14580	44528	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	177	1	0	2	2.1	c1coc(C2CN3CCC2CC3)c1	10.1021/jm00003a011
		15196236	125978	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
		CHEMBL343236	125978	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
		44415886	86610	0	None	-630	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	607	8	2	4	4.3	CC(C)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL212141	86610	0	None	-630	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	607	8	2	4	4.3	CC(C)NC(=O)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		44309108	109871	0	None	-52	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	372	4	3	3	3.6	O=C(Nc1ccc2c(c1)CNC2)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL307554	109871	0	None	-52	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	372	4	3	3	3.6	O=C(Nc1ccc2c(c1)CNC2)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		10830843	210742	0	None	-48	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	3	3	2.2	O=C(NC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL69383	210742	0	None	-48	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	4	3	3	2.2	O=C(NC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		44308799	210808	0	None	-19	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	1	3	3.5	CN(C)CCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL69765	210808	0	None	-19	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	1	3	3.5	CN(C)CCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44285557	106929	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	181	0	0	2	1.7	C[C@H]1CCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		CHEMBL287834	106929	0	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	181	0	0	2	1.7	C[C@H]1CCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		137636830	168003	0	None	-2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4061384	168003	0	None	-2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117956	168003	0	None	-2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	4	0	1	2.5	COc1cccc(C2CC2C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		73356869	99043	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426672	99043	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		118710660	127609	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	127609	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	127609	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		11740181	110202	0	None	-281	2	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(F)(F)F)cc1)C2	10.1021/jm00020a006
		CHEMBL3084873	110202	0	None	-281	2	Rat	5.8	pKi	=	5.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	375	4	0	2	5.4	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(F)(F)F)cc1)C2	10.1021/jm00020a006
		44274468	87381	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21508	87381	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	276	4	0	2	4.0	CN(C)CCC1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		13773336	86458	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2115342	86458	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		10025038	175606	0	None	-26	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.3	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL437781	175606	0	None	-26	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.3	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		164626977	195378	0	None	4	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4874412	195378	0	None	4	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028969	195378	0	None	4	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	532	8	2	6	2.9	NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		4189	213701	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	213701	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	213701	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		72190452	99053	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426682	99053	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		145961126	168332	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4128764	168332	0	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		11523051	103064	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2093084	103064	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL261194	103064	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		45266386	201695	0	None	1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		CHEMBL541424	201695	0	None	1	3	Human	4.8	pKi	=	4.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		23352279	214359	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	233	2	0	3	3.0	CC(=O)c1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
		CHEMBL94921	214359	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	233	2	0	3	3.0	CC(=O)c1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
		15105211	179655	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	11	0	3	3.8	CCN(CC)CCOCCN(C)CC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL451542	179655	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	11	0	3	3.8	CCN(CC)CCOCCN(C)CC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		16125398	91892	0	None	-20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL224783	91892	0	None	-20	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		9969695	167667	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	361	4	0	3	3.7	COC(C#C[C@@]1(OC)CN2CCC1CC2)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.024
		CHEMBL411514	167667	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	361	4	0	3	3.7	COC(C#C[C@@]1(OC)CN2CCC1CC2)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.024
		187	7043	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		294	7043	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		65	7043	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		8593	7043	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		CHEMBL667	7043	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		DB03128	7043	39	None	6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1016/j.bmcl.2007.11.073
		145961495	168225	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4127373	168225	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		11536903	9176	68	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		3262	9176	68	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		CHEMBL3770346	9176	68	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		16094810	144664	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsnc1OCCCOCCCOCCCOc1nsnc1-c1cccnc1	10.1021/jm0606995
		CHEMBL376295	144664	0	None	-1	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsnc1OCCCOCCCOCCCOc1nsnc1-c1cccnc1	10.1021/jm0606995
		71456285	86370	0	None	1	2	Rat	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@@H]1CCCCN1	10.1021/jm00087a008
		CHEMBL2114426	86370	0	None	1	2	Rat	4.8	pKi	=	4.8	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@@H]1CCCCN1	10.1021/jm00087a008
		24865895	102780	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL259662	102780	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL390842	102780	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		24865895	102780	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL259662	102780	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL390842	102780	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		44274433	106286	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL283320	106286	0	None	1	5	Human	4.8	pKi	=	4.8	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		24894516	179487	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@@H]2CCCN2C)o1	10.1021/jm800145d
		CHEMBL450463	179487	0	None	2	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@@H]2CCCN2C)o1	10.1021/jm800145d
		15196233	127893	0	None	-2	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	233	2	1	3	1.6	COc1ccccc1C1(O)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL357404	127893	0	None	-2	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	233	2	1	3	1.6	COc1ccccc1C1(O)CN2CCC1CC2	10.1021/jm00003a011
		44378753	127060	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		CHEMBL352607	127060	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	467	6	0	6	4.4	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)C[C@@H]3C)cc2)cc1	10.1016/s0960-894x(02)00023-9
		2028	9753	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		359	9753	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		4634	9753	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		CHEMBL1231	9753	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		DB01062	9753	80	None	-8	11	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.09.079
		3042	8196	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		355	8196	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		868	8196	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		CHEMBL1123	8196	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		DB00804	8196	35	None	-28	15	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
		44392933	173082	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	333	3	1	3	4.3	C[C@H]1CCC[C@H](CC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)N1	10.1016/j.bmcl.2004.05.047
		CHEMBL427145	173082	0	None	4	2	Human	7.8	pKi	=	7.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	333	3	1	3	4.3	C[C@H]1CCC[C@H](CC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)N1	10.1016/j.bmcl.2004.05.047
		118710660	127609	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	127609	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	127609	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		118710662	127608	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	127608	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	127608	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		56965018	83956	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042552	83956	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078967	83956	0	None	-7	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		164621443	195333	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4867483	195333	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028653	195333	0	None	5	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015141	185046	0	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4642045	185046	0	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650774	185046	0	None	-1	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	668	11	1	4	8.2	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.9b02172
		174174	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		260	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		320	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		CHEMBL517712	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		DB00572	7311	49	None	-7	14	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.6b01892
		302	9751	25	None	-4	8	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		4630	9751	25	None	-4	8	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL7634	9751	25	None	-4	8	Rat	6.8	pKi	=	6.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		15196236	125978	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
		CHEMBL343236	125978	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	229	1	0	2	2.3	c1ccc2c(c1)CC(C1CN3CCC1CC3)O2	10.1021/jm00003a011
		199230	169914	21	None	37	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		CHEMBL41779	169914	21	None	37	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		6098192	208580	14	None	-3	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL606901	208580	14	None	-3	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL306462	109742	0	None	-1	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	211	2	1	4	1.1	CCO/C(O)=C1\CN2CCCC(C2)C1=O	10.1021/jm020572p
		44318930	112949	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
		CHEMBL313738	112949	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
		53391301	99049	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426678	99049	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		462902	126631	1	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	460	4	0	6	3.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C#N)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL348667	126631	1	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	460	4	0	6	3.7	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C#N)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10660	21188	58	None	-4	12	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		CHEMBL1200406	21188	58	None	-4	12	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
		24894109	195807	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL509202	195807	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL551563	195807	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		162353376	187206	0	None	3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4752380	187206	0	None	3	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	3	1	3	1.4	O=C(CCN1CCCc2ccccc21)N1CCC(O)C1	10.1016/j.bmcl.2020.127632
		14925759	164817	6	None	-5754	13	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	349	5	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4085780	164817	6	None	-5754	13	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	349	5	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		46227415	20901	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL1198050	20901	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL593871	20901	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		16125683	91425	0	None	-36	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	431	5	1	2	5.5	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(C4CCCCC4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL222403	91425	0	None	-36	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	431	5	1	2	5.5	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(C4CCCCC4)NC3=O)CC2)c1	10.1021/jm061159a
		939078	69843	2	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		CHEMBL1788286	69843	2	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		2562	211378	56	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL1256696	211378	56	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL73234	211378	56	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		462573	36302	1	None	-316	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1cncc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL138502	36302	1	None	-316	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1cncc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		16125506	91554	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	5.1	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCCc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL223187	91554	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	5.1	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCCc2ccccc2)CC1	10.1021/jm061159a
		463210	171694	1	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	561	4	0	5	4.5	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(I)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL422326	171694	1	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	561	4	0	5	4.5	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(I)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		135398737	7745	93	None	-22	90	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	7745	93	None	-22	90	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	7745	93	None	-22	90	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	7745	93	None	-22	90	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	7745	93	None	-22	90	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		9968046	204942	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL57485	204942	0	None	3	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		44450637	161975	0	None	12	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL402473	161975	0	None	12	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
		162353379	187741	0	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4758449	187741	0	None	2	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	3	0	2	2.1	O=C(CCN1CCCc2ccccc21)N1CCC1	10.1016/j.bmcl.2020.127632
		44386115	138216	0	None	-8	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	650	16	3	4	6.2	O=C(CCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL369062	138216	0	None	-8	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	650	16	3	4	6.2	O=C(CCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		44295977	199510	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL52203	199510	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267762	22210	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	518	6	0	4	5.6	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12150	22210	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	518	6	0	4	5.6	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		9889312	85205	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	85205	0	None	2	5	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		44312066	171160	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	494	7	0	4	6.4	COc1ccc([S+]([O-])c2ccc(C(C3CCCCC3)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL421304	171160	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	494	7	0	4	6.4	COc1ccc([S+]([O-])c2ccc(C(C3CCCCC3)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		302	9751	25	None	-34	8	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		4630	9751	25	None	-34	8	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		CHEMBL7634	9751	25	None	-34	8	Human	7.8	pKi	=	7.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		71459971	86314	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2114066	86314	0	None	1	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44627852	20811	0	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197387	20811	0	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569712	20811	0	None	-2	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	338	4	0	1	5.9	C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		10314131	110201	0	None	-8	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	323	4	1	3	4.1	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(O)cc1)C2	10.1021/jm00020a006
		CHEMBL3084872	110201	0	None	-8	2	Rat	7.8	pKi	=	7.8	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	323	4	1	3	4.1	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(O)cc1)C2	10.1021/jm00020a006
		164627575	195387	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4873979	195387	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5029004	195387	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	859	21	8	11	1.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44593625	194909	0	None	-5	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL498358	194909	0	None	-5	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539120	194909	0	None	-5	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		44383415	127544	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	8	0	8	3.1	CCOCC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL355299	127544	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	8	0	8	3.1	CCOCC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		11819545	44179	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccoc2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL145488	44179	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccoc2)C2CCN1CC2	10.1021/jm00003a011
		11819883	127769	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2ccsc2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL356321	127769	2	None	-2	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2ccsc2)C2CCN1CC2	10.1021/jm00003a011
		46878242	208590	0	None	-154	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@H](O)c2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL606962	208590	0	None	-154	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@H](O)c2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		146025727	178464	0	None	-63	27	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	178464	0	None	-63	27	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		44328561	214146	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	243	3	0	3	2.5	COc1ccccc1C(=O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
		CHEMBL93709	214146	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	243	3	0	3	2.5	COc1ccccc1C(=O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
		10105296	212701	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
		CHEMBL84113	212701	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
		155552185	180840	0	None	-30902	16	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4544086	180840	0	None	-30902	16	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)Displacement of [3H] NMS from muscarinic M2 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		45786849	164584	34	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4083241	164584	34	None	-1	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	3	1	3	1.4	c1cncc(COC2CCCNC2)c1	10.1021/acs.jmedchem.7b01113
		10718110	46689	0	None	-1905	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	2	4	3.8	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
		CHEMBL147778	46689	0	None	-1905	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	2	4	3.8	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
		10671167	128277	0	None	-602	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	448	6	2	3	4.9	O=C(NC1CCN(CC2CCCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL358289	128277	0	None	-602	3	Human	4.8	pKi	=	4.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	448	6	2	3	4.9	O=C(NC1CCN(CC2CCCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		190868	19914	3	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
		CHEMBL1190617	19914	3	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
		CHEMBL541284	19914	3	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	422	7	0	5	4.8	O=C(OCCN1CCC(c2ccccc2)CC1)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00039a008
		2200	9905	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		328	9905	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		4848	9905	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		CHEMBL9967	9905	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		DB00670	9905	46	None	-35	13	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/j.bmc.2008.06.025
		73346332	99310	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	297	3	0	2	2.6	CN(Cc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432041	99310	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	297	3	0	2	2.6	CN(Cc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		44299616	202487	0	None	-1	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL55698	202487	0	None	-1	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		92218234	127605	1	None	12	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
		CHEMBL3309718	127605	1	None	12	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
		CHEMBL3558072	127605	1	None	12	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	160	2	0	2	0.1	C[N+](C)(C)C[C@@H]1COCCO1	10.1016/j.bmcl.2014.06.020
		46227411	20893	0	None	2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL1198027	20893	0	None	2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL593443	20893	0	None	2	3	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@H]1CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		15678857	210811	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	408	6	2	6	1.7	NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL69796	210811	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	408	6	2	6	1.7	NCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		156010212	185016	0	None	-4	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4634066	185016	0	None	-4	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650562	185016	0	None	-4	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		302	9751	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		4630	9751	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		CHEMBL7634	9751	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		137635734	162891	0	None	-61	8	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	377	7	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4063176	162891	0	None	-61	8	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	377	7	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		44296007	108741	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	529	5	1	3	6.1	CC(C)(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL301354	108741	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	529	5	1	3	6.1	CC(C)(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267703	21730	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	501	7	1	4	5.0	NC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12085	21730	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	501	7	1	4	5.0	NC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44344029	16892	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	632	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL115642	16892	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	632	7	0	7	5.8	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		15050957	210373	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	566	9	1	7	3.8	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL66914	210373	0	None	1	2	Rat	7.8	pKi	=	7.8	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	566	9	1	7	3.8	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		118710660	127609	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	127609	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	127609	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		174174	7311	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	7311	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	7311	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	7311	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	7311	49	None	-7	14	Human	7.7	pKi	=	7.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		118710660	127609	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	127609	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	127609	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		14939895	88894	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201997	88894	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL216629	88894	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	993	30	3	11	10.1	COc1ccccc1CNCCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		10404824	110208	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	337	5	0	3	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		CHEMBL3084880	110208	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	337	5	0	3	4.4	COc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		44392906	19032	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL1184677	19032	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL363895	19032	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	360	1	0	3	4.0	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3[C@@H]([C@@H]3CC4CCC(C)(C)[N+]4(C)O3)[C@@H]12	10.1016/j.bmcl.2004.05.047
		55005	111552	8	None	-1	3	Rat	6.8	pKi	=	6.8	Binding	Tested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heartTested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL310852	111552	8	None	-1	3	Rat	6.8	pKi	=	6.8	Binding	Tested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heartTested for binding affinity to [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		11610557	78806	0	None	-85	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL197588	78806	0	None	-85	3	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
		10619926	46576	0	None	-35	3	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	382	6	2	4	3.4	O=C(NC1CCN(Cc2ccoc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL147672	46576	0	None	-35	3	Human	5.8	pKi	=	5.8	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	382	6	2	4	3.4	O=C(NC1CCN(Cc2ccoc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		176	7186	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	7186	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	7186	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	7186	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	7186	66	None	-2	31	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		10033774	63320	0	None	-4	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	927	31	0	8	12.0	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
		CHEMBL163901	63320	0	None	-4	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	927	31	0	8	12.0	CN(CCCCCCCCN(C)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1)CCCCCCN1CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1	10.1016/0960-894X(95)00113-8
		16125257	151454	0	None	-7	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	350	3	1	1	3.2	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061160+
		CHEMBL390839	151454	0	None	-7	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	350	3	1	1	3.2	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061160+
		57326142	83955	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL2042401	83955	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL2078965	83955	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		46227457	20906	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL1198075	20906	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL594801	20906	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		16125621	91138	0	None	-22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	426	5	2	3	4.2	Nc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL221829	91138	0	None	-22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	426	5	2	3	4.2	Nc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		2200	9905	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		328	9905	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		4848	9905	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		CHEMBL9967	9905	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		DB00670	9905	46	None	-31	13	Rat	4.7	pKi	=	4.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		44383064	127085	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	381	4	0	3	4.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCc4ccccc4C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL352756	127085	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	381	4	0	3	4.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCc4ccccc4C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		10807270	107233	0	None	5	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	342	3	1	3	3.8	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCCC1	10.1021/jm970333f
		CHEMBL290675	107233	0	None	5	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	342	3	1	3	3.8	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCCC1	10.1021/jm970333f
		162667844	189312	0	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4787283	189312	0	None	-1	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	Cc1ccc2c(c1)CCCN2CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
		16124707	144924	0	None	-67	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	5	1	4	4.9	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		CHEMBL376781	144924	0	None	-67	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	5	1	4	4.9	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		44382841	66176	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	351	4	0	4	3.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCSCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL170977	66176	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	351	4	0	4	3.8	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCSCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		43815	193699	64	None	-15	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		CHEMBL1708	193699	64	None	-15	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		CHEMBL490	193699	64	None	-15	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	nan
		5648	85186	9	None	-2	5	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		CHEMBL2107687	85186	9	None	-2	5	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		CHEMBL2111176	85186	9	None	-2	5	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	nan
		16086063	87337	0	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	744	11	2	5	5.8	O=C(NCC1CCN(CC2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL214898	87337	0	None	-100	5	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	744	11	2	5	5.8	O=C(NCC1CCN(CC2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		71741394	127613	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323287	127613	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558239	127613	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		164613685	195268	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4861655	195268	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028207	195268	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		15157138	106401	0	None	-6	4	Human	7.7	pKi	=	7.7	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	345	9	0	3	4.8	CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL284137	106401	0	None	-6	4	Human	7.7	pKi	=	7.7	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	345	9	0	3	4.8	CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		155557119	183290	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4555411	183290	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4596899	183290	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		155557119	183290	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4555411	183290	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596899	183290	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	868	17	7	8	5.1	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		10155850	103517	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL264414	103517	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		44627860	20807	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197371	20807	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL568870	20807	0	None	-2	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		10789183	111144	0	None	-25	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL310132	111144	0	None	-25	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	438	5	0	2	6.3	O=C(c1ccccc1)N(c1ccc(Cl)c(Cl)c1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44319009	113713	0	None	-15	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL314831	113713	0	None	-15	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	426	5	0	2	5.2	O=C(C1CCC1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44318782	212912	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85996	212912	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	482	5	0	2	6.4	O=C(c1ccc(Cl)cc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		154734599	9281	12	None	-1	12	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
		327	9281	12	None	-1	12	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
		4108	9281	12	None	-1	12	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
		CHEMBL27673	9281	12	None	-1	12	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm981038d
		44318851	111503	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		CHEMBL310558	111503	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		164608958	195239	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4846447	195239	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5027936	195239	0	None	7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		14964511	18873	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1183954	18873	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL325473	18873	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		10465050	42961	2	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2ccccn2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL144493	42961	2	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2ccccn2)C2CCN1CC2	10.1021/jm00003a011
		162353393	186218	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
		CHEMBL4740422	186218	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	312	5	1	2	3.3	O=C(CCN1CCCc2ccccc21)NCc1cccc(F)c1	10.1016/j.bmcl.2020.127632
		137661377	165988	0	None	-363	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	314	6	0	2	3.9	CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4098720	165988	0	None	-363	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	314	6	0	2	3.9	CCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		24894630	195748	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL508347	195748	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL555475	195748	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc(C2CCC[N+]2(C)C)o1	10.1021/jm800145d
		156016047	185039	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4647816	185039	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650722	185039	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		44267758	19152	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	470	6	0	3	6.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11856	19152	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	470	6	0	3	6.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4Cl)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44400218	74403	0	None	-2	2	Rat	5.7	pKi	=	5.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	383	6	1	5	2.6	COc1ccc(C(O)(C(=O)OCC#CCN2CC3CC3C2)C2CCCC2)cc1	10.1016/j.bmcl.2005.02.036
		CHEMBL190459	74403	0	None	-2	2	Rat	5.7	pKi	=	5.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	383	6	1	5	2.6	COc1ccc(C(O)(C(=O)OCC#CCN2CC3CC3C2)C2CCCC2)cc1	10.1016/j.bmcl.2005.02.036
		73352415	99313	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	293	4	0	2	2.5	CN(CCc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432044	99313	0	None	1	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	293	4	0	2	2.5	CN(CCc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		44593622	194575	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL495888	194575	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL556390	194575	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		156015809	185097	0	None	5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4645019	185097	0	None	5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651096	185097	0	None	5	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		11833737	127117	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		CHEMBL352966	127117	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		73347725	99045	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426674	99045	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
		24894633	183679	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@H]2CCCN2C)o1	10.1021/jm800145d
		CHEMBL461709	183679	0	None	1	5	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	165	1	0	2	2.4	Cc1ccc([C@H]2CCCN2C)o1	10.1021/jm800145d
		73355415	99308	0	None	1	13	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
		CHEMBL2432039	99308	0	None	1	13	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	277	3	1	1	2.1	C1C2C3CC4C2C2C1C3[C@H](NCC13C5C6C7C5C1C7C63)C42	10.1016/j.bmc.2013.07.045
		10852782	175059	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	314	3	1	3	3.0	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCC1	10.1021/jm970333f
		CHEMBL43398	175059	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	314	3	1	3	3.0	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCC1	10.1021/jm970333f
		5281825	114325	11	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00566-8
		CHEMBL318849	114325	11	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00566-8
		44329347	214867	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C[C@@H]3CCCC[C@H]32)N1C	10.1016/s0960-894x(02)00566-8
		CHEMBL97765	214867	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@@H]3[C@@H](C)OC(=O)[C@@H]3C[C@@H]3CCCC[C@H]32)N1C	10.1016/s0960-894x(02)00566-8
		11504244	113296	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	113296	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	113296	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	113296	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		3652	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		156010398	185015	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4633895	185015	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650561	185015	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		156011112	185054	0	None	4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4633679	185054	0	None	4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650842	185054	0	None	4	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Sc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		145960427	168229	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4127428	168229	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@@]1(C(=O)O[C@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		42853214	213233	0	None	-7	2	Human	6.7	pKi	=	6.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	376	5	0	3	5.1	O=C(c1cccs1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL88078	213233	0	None	-7	2	Human	6.7	pKi	=	6.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	376	5	0	3	5.1	O=C(c1cccs1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		25025581	208775	0	None	-3	8	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
		CHEMBL608151	208775	0	None	-3	8	Human	6.7	pKi	=	6.7	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	285	4	1	2	3.1	CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1	10.1021/jm901818u
		10663237	154005	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	316	5	1	3	3.3	CCN(CC)CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm970333f
		CHEMBL39284	154005	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	316	5	1	3	3.3	CCN(CC)CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm970333f
		71459909	85390	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	444	5	0	3	6.4	O=C(c1cccs1)N(c1c(Cl)cccc1Cl)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL2112313	85390	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	444	5	0	3	6.4	O=C(c1cccs1)N(c1c(Cl)cccc1Cl)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		73350846	99041	0	None	1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426670	99041	0	None	1	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		46227455	20942	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL1198609	20942	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL608985	20942	0	None	4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1O[C@H](C[N+](C)(C)C)CO[C@@H]1C	10.1016/j.bmc.2009.10.027
		44406573	79749	0	None	-6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200693	79749	0	None	-6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#CC(O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406690	81768	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cncnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL203249	81768	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cncnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		9871871	127536	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	7	0	8	2.9	CCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL355169	127536	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	536	7	0	8	2.9	CCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		9843814	134027	0	None	25	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
		CHEMBL36583	134027	0	None	25	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	398	9	1	5	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)NC)cc1	10.1021/jm00127a020
		44431383	94797	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234439	94797	0	None	1	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		16125370	91421	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	5.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL222387	91421	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	5.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCCN(Cc2ccccc2)CC1	10.1021/jm061159a
		155522355	183188	0	None	31	5	Human	8.7	pKi	=	8.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4451030	183188	0	None	31	5	Human	8.7	pKi	=	8.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596065	183188	0	None	31	5	Human	8.7	pKi	=	8.7	Binding	Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting methodCompetitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scintillation counting method	ChEMBL	732	19	8	8	2.3	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		44295965	196359	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	515	6	1	3	5.7	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51459	196359	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	515	6	1	3	5.7	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		10470	9266	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		1689	9266	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		4057	9266	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		CHEMBL524004	9266	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		DB04843	9266	7	None	-4	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	10.1016/j.bmc.2019.06.016
		140844422	183220	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4452706	183220	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596309	183220	0	None	3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	490	8	1	3	5.4	O=C(OC1C[N+]2(CCCc3cccc(Cl)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		10104167	8840	2	None	13	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	8840	2	None	13	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	8840	2	None	13	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		44311704	210980	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL70848	210980	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44311704	210980	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL70848	210980	0	None	53	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	510	7	0	5	4.9	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)C(C)C)CC2)CC1	10.1016/s0960-894x(00)00457-1
		688566	202662	24	None	-1	3	Rat	8.7	pKi	=	8.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		CHEMBL558910	202662	24	None	-1	3	Rat	8.7	pKi	=	8.7	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	337	4	1	4	2.6	O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		10107360	85682	28	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	273	5	0	5	2.7	CN1CCC=C(c2nsnc2SCCCF)C1	10.1021/jm00001a002
		CHEMBL2112939	85682	28	None	-	1	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	273	5	0	5	2.7	CN1CCC=C(c2nsnc2SCCCF)C1	10.1021/jm00001a002
		164614388	195276	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4848683	195276	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028251	195276	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	23	12	11	0.1	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44343736	117363	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6c(Cl)cccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL325451	117363	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	658	7	0	7	6.1	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6c(Cl)cccc6Cl)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		134272561	183206	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4540604	183206	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4596189	183206	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	442	7	1	3	4.3	O=C(OC1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		44627858	20810	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197382	20810	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569307	20810	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		16125642	148788	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL387546	148788	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	442	7	1	2	4.3	C[N+]1(CCOc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		154734599	9281	12	None	1	12	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
		327	9281	12	None	1	12	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
		4108	9281	12	None	1	12	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
		CHEMBL27673	9281	12	None	1	12	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.bmc.2007.01.022
		14939891	176143	0	None	-3	4	Rat	8.6	pKi	=	8.6	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL442014	176143	0	None	-3	4	Rat	8.6	pKi	=	8.6	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		44296054	195935	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	573	6	1	5	5.3	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51096	195935	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	573	6	1	5	5.3	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccc(F)c6ccccc56)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		10119364	50024	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL150624	50024	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		44431381	155800	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL394254	155800	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		164616974	195297	0	None	9	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4857722	195297	0	None	9	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028407	195297	0	None	9	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	675	15	7	8	2.2	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44378765	63318	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	542	6	1	7	3.5	CCNC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		CHEMBL163887	63318	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	542	6	1	7	3.5	CCNC(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00023-9
		44344030	16925	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	588	7	0	6	5.4	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL115807	16925	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	588	7	0	6	5.4	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		174174	7311	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	7311	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	7311	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	7311	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	7311	49	None	-7	14	Human	8.6	pKi	=	8.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		10104167	8840	2	None	13	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	8840	2	None	13	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	8840	2	None	13	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		10109563	165319	0	None	-7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL409151	165319	0	None	-7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	367	3	1	3	4.0	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		16094788	148693	0	None	5	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL386983	148693	0	None	5	5	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	531	19	0	14	1.6	COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		10606253	164052	0	None	1	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		CHEMBL407678	164052	0	None	1	5	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1152	27	4	13	9.2	CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		13981865	119589	2	None	11	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		CHEMBL3289391	119589	2	None	11	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		CHEMBL3306998	119589	2	None	11	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	ChEMBL	340	4	1	3	2.7	C[N+]1(C)CCC[C@H](OC(=O)C(O)(c2ccccc2)c2ccccc2)C1	10.1016/j.bmc.2014.04.029
		1201549	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		333	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		7601	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		CHEMBL1201203	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		CHEMBL438151	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		DB00245	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1021/jm00020a006
		44378862	64893	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	7	0	6	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00024-0
		CHEMBL167629	64893	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	575	7	0	6	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)cc1	10.1016/s0960-894x(02)00024-0
		16065268	74703	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	456	9	1	3	5.6	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CCC(Oc2ccccc2)CC1	10.1021/jm200884j
		CHEMBL1910849	74703	0	None	-2	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayDisplacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assay	ChEMBL	456	9	1	3	5.6	CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CCC(Oc2ccccc2)CC1	10.1021/jm200884j
		155542840	183172	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4521993	183172	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4595947	183172	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	540	9	1	4	5.6	O=C(OC1C[N+]2(CCCc3ccc(OC(F)(F)F)cc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		9815331	209886	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		CHEMBL64000	209886	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		9815331	209886	1	None	1	8	Rat	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	209886	1	None	1	8	Rat	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		9815331	209886	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64000	209886	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9705115
		9815331	209886	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1016/j.bmc.2007.12.036
		CHEMBL64000	209886	1	None	-1	8	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1016/j.bmc.2007.12.036
		154417	100035	60	None	-10	9	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
		CHEMBL2449003	100035	60	None	-10	9	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1016/j.bmcl.2007.12.051
		155538050	179128	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	550	6	0	4	6.0	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4475862	179128	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assayDisplacement of [3H]-QNB from human muscarinic M2 receptor expressed in stable CHO-K1 cells incubated for 120 mins by radioligand competition binding assay	ChEMBL	550	6	0	4	6.0	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1	10.1021/acs.jmedchem.8b01967
		44295618	171906	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1cccc(C(=O)N2CCC(N3CCC(C4(c5ccc(C(=O)NC(C)C)cc5)OCCO4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		CHEMBL422763	171906	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	534	6	2	6	3.9	Cc1cccc(C(=O)N2CCC(N3CCC(C4(c5ccc(C(=O)NC(C)C)cc5)OCCO4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		44267706	170028	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	574	10	0	6	6.5	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(OCC)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL418530	170028	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	574	10	0	6	6.5	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(OCC)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		10119364	50024	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL150624	50024	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	532	5	0	3	6.7	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		9889312	85205	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	85205	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		2705	10614	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		360	10614	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		443879	10614	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		CHEMBL1382	10614	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		DB01036	10614	64	None	-1	10	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2007.11.022
		2705	10614	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		360	10614	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		443879	10614	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		CHEMBL1382	10614	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		DB01036	10614	64	None	-1	10	Rat	8.6	pKi	=	8.6	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1021/acs.jmedchem.8b00041
		16115796	143995	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL375073	143995	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		16115951	148421	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL385328	148421	0	None	-3	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		12872437	18830	0	None	-2	5	Rat	8.6	pKi	=	8.6	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
		CHEMBL1183585	18830	0	None	-2	5	Rat	8.6	pKi	=	8.6	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
		CHEMBL306182	18830	0	None	-2	5	Rat	8.6	pKi	=	8.6	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	338	2	0	3	3.1	C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00403-G
		9889312	85205	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2111540	85205	0	None	2	5	Human	8.6	pKi	=	8.6	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		154417	100035	60	None	-18	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	100035	60	None	-18	9	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		118710664	127610	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	127610	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	127610	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		118710664	127610	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	127610	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	127610	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		57326235	83960	0	None	-5	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042405	83960	0	None	-5	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079009	83960	0	None	-5	5	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		9871136	213894	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	514	7	0	7	4.0	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL92110	213894	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	514	7	0	7	4.0	CCOC(=O)N1CCC(N2CCC(C(=O)c3ccc(S(=O)(=O)c4ccc(OC)cc4)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		164621814	195335	0	None	22	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4867301	195335	0	None	22	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028667	195335	0	None	22	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44311835	211316	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL72787	211316	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/s0960-894x(00)00457-1
		44311835	211316	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL72787	211316	0	None	31	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	558	8	0	5	5.5	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)Cc3ccccc3)CC2)CC1	10.1016/j.bmcl.2007.01.058
		44267725	18096	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11794	18096	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267772	22566	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	465	6	1	4	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		CHEMBL12228	22566	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	465	6	1	4	5.6	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(SC(C)C)cc4)CC3)CC2)c1N	10.1016/s0960-894x(02)00096-3
		10269504	141151	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL371734	141151	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406268	147574	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL381878	147574	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44213237	108698	0	None	-16	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		CHEMBL300998	108698	0	None	-16	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	291	8	0	5	2.5	CCCCCCOc1nccnc1OC1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		9889312	85205	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	85205	0	None	2	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		2551	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		298	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		488	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		CHEMBL965	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		DB00411	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		15050956	109705	0	None	3	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	552	8	1	7	3.4	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL306201	109705	0	None	3	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	552	8	1	7	3.4	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		2551	7581	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	7581	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	7581	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	7581	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	7581	23	None	-3	11	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		2551	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		298	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		488	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		CHEMBL965	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		DB00411	7581	23	None	-6	11	Human	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9705115
		10557581	28546	0	None	-3	5	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL1202001	28546	0	None	-3	5	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL131913	28546	0	None	-3	5	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	873	27	4	10	8.1	CN(CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCNCC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		10398843	43181	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	227	1	0	2	3.2	c1ccc2oc(C3CN4CCC3CC4)cc2c1	10.1021/jm00003a011
		CHEMBL144693	43181	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	227	1	0	2	3.2	c1ccc2oc(C3CN4CCC3CC4)cc2c1	10.1021/jm00003a011
		137629935	167799	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	167799	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	167799	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		10622033	49556	0	None	-323	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
		CHEMBL150219	49556	0	None	-323	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	420	7	2	3	4.2	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1021/jm0003135
		208598	42702	5	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2ccccn2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL144247	42702	5	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2ccccn2)CN2CCC1CC2	10.1021/jm00003a011
		6075	156887	42	None	-7	16	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		CHEMBL395110	156887	42	None	-7	16	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
		16125529	143984	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL374987	143984	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		463892	38651	1	None	-18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	533	5	0	6	4.9	COc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
		CHEMBL140706	38651	1	None	-18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	533	5	0	6	4.9	COc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
		44392898	129866	0	None	7	2	Human	6.7	pKi	=	6.7	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	2	1	4	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C(O)=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL360988	129866	0	None	7	2	Human	6.7	pKi	=	6.7	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	2	1	4	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C(O)=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		71575027	92998	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	379	8	0	4	4.4	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		CHEMBL2312389	92998	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	379	8	0	4	4.4	CCN1CCC(c2ccccc2)=C(C(=O)OCCCc2ccc(OC)cc2)C1	10.1021/jm301774u
		463616	38824	1	None	-2884	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	542	4	0	4	6.2	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)cncc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
		CHEMBL140827	38824	1	None	-2884	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	542	4	0	4	6.2	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)cncc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
		2335	18620	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	18620	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	18620	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	18620	22	None	-2	12	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		306	10229	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		3536	10229	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		53930639	10229	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		9577995	10229	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		CHEMBL134641	10229	21	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	10.1016/j.bmc.2007.12.036
		11504244	113296	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	113296	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	113296	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	113296	0	None	199	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		10236758	122550	5	None	-208	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	328	7	0	2	4.3	CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/jm501173q
		CHEMBL3354065	122550	5	None	-208	13	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	328	7	0	2	4.3	CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/jm501173q
		137655636	165515	0	None	-95	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	376	7	0	2	4.7	O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4093527	165515	0	None	-95	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	376	7	0	2	4.7	O=C1CCc2ccccc2N1CCCN1CCC(CCc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		44437249	18644	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
		CHEMBL1182436	18644	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
		CHEMBL238825	18644	0	None	2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	235	3	0	3	1.6	Cc1cc(OCC#CC[N+]2(C)CCCC2)no1	10.1016/j.bmc.2007.09.003
		137629935	167799	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4060823	167799	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116342	167799	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	206	3	0	1	1.9	C[N+](C)(C)CCc1ccc2c(c1)OCC2	10.1021/acs.jmedchem.7b01113
		16125372	91429	0	None	-74	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	447	5	1	2	4.9	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL222424	91429	0	None	-74	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	447	5	1	2	4.9	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		118719927	122559	0	None	-2	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	386	11	1	3	4.4	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354074	122559	0	None	-2	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	386	11	1	3	4.4	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCO)CC1	10.1021/jm501173q
		6603753	115479	1	None	5	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	176	2	0	2	1.2	C[C@@H]1O[C@H](C[N+](C)(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL320820	115479	1	None	5	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	176	2	0	2	1.2	C[C@@H]1O[C@H](C[N+](C)(C)C)CS1	10.1016/j.bmc.2007.12.036
		44422692	18625	0	None	5	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1182296	18625	0	None	5	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL228144	18625	0	None	5	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		24865895	102780	0	None	1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		CHEMBL259662	102780	0	None	1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		CHEMBL390842	102780	0	None	1	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2014.06.020
		44383595	172894	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	5	0	3	5.0	CCC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
		CHEMBL426032	172894	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	5	0	3	5.0	CCC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
		10476118	130605	0	None	-4	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	400	4	0	3	3.2	CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc12	10.1016/S0960-894X(97)00143-1
		CHEMBL362438	130605	0	None	-4	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	400	4	0	3	3.2	CCN(CC)CC#CCN1C(=O)CC2(C1=O)c1ccccc1CCc1ccccc12	10.1016/S0960-894X(97)00143-1
		134271233	183318	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4591883	183318	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4597134	183318	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	428	6	1	3	4.3	O=C(OC1C[N+]2(Cc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		118710664	127610	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	127610	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	127610	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		164622170	195339	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4863723	195339	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028687	195339	0	None	7	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	846	20	9	12	-0.4	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44593626	194632	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496306	194632	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539121	194632	0	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		15050953	109116	0	None	1	4	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	536	9	2	7	4.0	CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL303684	109116	0	None	1	4	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	536	9	2	7	4.0	CC(C)(C)OC(=O)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		101676031	104103	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		16175987	104103	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201998	104103	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL269272	104103	0	None	-4	4	Rat	7.7	pKi	=	7.7	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		16664965	91677	0	None	-28	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL223668	91677	0	None	-28	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	462	6	1	1	4.7	C[N+]1(CCc2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		44308733	108967	0	None	-138	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	5	2	3	3.3	CC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL302809	108967	0	None	-138	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	5	2	3	3.3	CC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		611037	210473	1	None	-3	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	399	4	1	5	2.2	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCl)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL67532	210473	1	None	-3	4	Rat	6.7	pKi	=	6.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	399	4	1	5	2.2	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCl)CC2)c2ccccc21	10.1021/jm00111a032
		14956862	20507	0	None	-10	2	Rat	5.7	pKi	=	5.7	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
		CHEMBL1195116	20507	0	None	-10	2	Rat	5.7	pKi	=	5.7	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
		CHEMBL553865	20507	0	None	-10	2	Rat	5.7	pKi	=	5.7	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	256	0	0	4	1.4	CN1CCC2(CC1)OC(=S)N(C(C)(C)C)C2=O	10.1021/jm00068a005
		14964513	18191	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1180268	18191	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL119508	18191	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		14964497	21063	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119985	21063	0	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		10622718	45176	0	None	-1174	3	Human	4.7	pKi	=	4.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	3	4.5	O=C(NC1CCN(CC2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL146359	45176	0	None	-1174	3	Human	4.7	pKi	=	4.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	3	4.5	O=C(NC1CCN(CC2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		15086397	20492	0	None	-26	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1195036	20492	0	None	-26	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL553755	20492	0	None	-26	2	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	314	7	0	4	3.3	CCN(CC)CCOC(=O)C1(c2ccc(C#N)cc2)CCCC1	10.1021/jm00114a005
		3652	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	10869	79	None	-18	18	Human	6.7	pKi	=	6.7	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		118719928	122560	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	414	13	1	3	5.2	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354075	122560	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	414	13	1	3	5.2	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCO)CC1	10.1021/jm501173q
		156013536	185090	0	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4639297	185090	0	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651058	185090	0	None	-3	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		108993439	186639	1	None	3	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	CC1Cc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4745429	186639	1	None	3	4	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	CC1Cc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
		71452382	90569	0	None	-6	10	Human	6.7	pKi	=	6.7	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205812	90569	0	None	-6	10	Human	6.7	pKi	=	6.7	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1	10.1016/j.bmcl.2012.08.046
		44593617	194210	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493795	194210	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		11048067	12351	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.6	CCOC(=O)c1c(C)n(CC)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL107679	12351	0	None	-1	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.6	CCOC(=O)c1c(C)n(CC)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		135430667	11730	0	None	-35	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	402	2	1	6	4.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(-c5nc(C)no5)c34)OC21	10.1021/jm011116o
		CHEMBL104803	11730	0	None	-35	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	402	2	1	6	4.3	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(-c5nc(C)no5)c34)OC21	10.1021/jm011116o
		11143997	11794	0	None	-309	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	408	3	1	5	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		CHEMBL105122	11794	0	None	-309	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	408	3	1	5	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		10225881	114398	0	None	-724	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	6	1	5	5.9	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		CHEMBL318995	114398	0	None	-724	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	6	1	5	5.9	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3	10.1021/jm011116o
		58438451	99060	0	None	-2089	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426689	99060	0	None	-2089	2	Human	4.7	pKi	=	4.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		44437298	18659	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL1182460	18659	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL239436	18659	0	None	7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	237	2	0	3	1.4	C[N+]1(CC#CCOC2=NOCC2)CCCCC1	10.1016/j.bmc.2007.09.003
		9998202	75941	0	None	-2	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192485	75941	0	None	-2	2	Rat	7.7	pKi	=	7.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		44267749	19720	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(F)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11893	19720	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cc(F)ccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267693	175963	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL440601	175963	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		11595794	142479	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
		CHEMBL372983	142479	0	None	-3	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
		44313630	211598	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	401	9	0	4	5.1	CCN(CC)CCOCOC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		CHEMBL75217	211598	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	401	9	0	4	5.1	CCN(CC)CCOCOC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		10525412	48748	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cc1	10.1021/jm0003135
		CHEMBL149486	48748	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cc1	10.1021/jm0003135
		15050961	210601	0	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	612	16	2	7	5.8	COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL68446	210601	0	None	-6	2	Rat	7.7	pKi	=	7.7	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	612	16	2	7	5.8	COc1ccccc1CNCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		155525065	183333	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4456524	183333	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597243	183333	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	590	11	4	6	2.9	CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		1935	10506	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		2551	10506	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		6687	10506	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		CHEMBL95	10506	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		DB00382	10506	97	None	-6	6	Mouse	6.7	pKi	=	6.7	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	10.1021/jm00095a008
		44568347	198430	0	None	-10	15	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL519609	198430	0	None	-10	15	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assayAntagonist activity at muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		155518181	177040	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	404	4	0	3	5.2	O=C(OCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		CHEMBL4446039	177040	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	404	4	0	3	5.2	O=C(OCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		16085999	87067	0	None	-457	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	10	3	5	4.3	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL214029	87067	0	None	-457	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	10	3	5	4.3	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		10646906	126011	0	None	-63	3	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1	10.1021/jm0003135
		CHEMBL343449	126011	0	None	-63	3	Human	6.7	pKi	=	6.7	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1	10.1021/jm0003135
		44309089	109787	0	None	-128	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	5	3	3	2.4	O=C(NCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL306903	109787	0	None	-128	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	5	3	3	2.4	O=C(NCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		10061123	43664	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2csc3ccccc23)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL145081	43664	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2csc3ccccc23)CN2CCC1CC2	10.1021/jm00003a011
		44207909	23471	3	None	-8	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
		CHEMBL1242923	23471	3	None	-8	9	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	407	7	1	4	2.6	O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1	10.1021/jm100697g
		44328540	214561	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	245	3	1	3	2.3	COc1ccccc1C(O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
		CHEMBL96042	214561	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	245	3	1	3	2.3	COc1ccccc1C(O)C1=CN2CCC1CC2	10.1016/S0960-894X(01)80824-6
		14964499	176168	3	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL442206	176168	3	None	-	1	Rat	4.7	pKi	=	4.7	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		137630043	167816	0	None	-1	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4099667	167816	0	None	-1	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116455	167816	0	None	-1	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	1	2.4	COc1cccc(/C=C/C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		44400185	76101	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@@]3(C)C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		CHEMBL192885	76101	0	None	-1	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@@]3(C)C2)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		44295977	199510	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
		CHEMBL52203	199510	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	536	6	0	4	5.7	CC(C)S(=O)(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5ccccc45)CC3)CC2)cc1	10.1021/jm0255163
		1273944	209374	20	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
		CHEMBL612034	209374	20	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
		73352329	99040	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426669	99040	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		156015719	185037	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4646457	185037	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650699	185037	0	None	-4	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		156011605	185062	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4638067	185062	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650888	185062	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.4	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(Cc3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		10101246	16318	0	None	-81	2	Human	4.7	pKi	=	4.7	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL112297	16318	0	None	-81	2	Human	4.7	pKi	=	4.7	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		9998202	75941	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192485	75941	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		44382865	127059	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	4	0	3	4.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(C)(C)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL352596	127059	0	None	1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	361	4	0	3	4.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCC(C)(C)C3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		16125620	91422	0	None	-93	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	4.9	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL222388	91422	0	None	-93	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	1	2	4.9	Cc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		15105209	110396	1	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	318	11	1	3	3.4	CCN(CC)CCOCCNCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL308707	110396	1	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	318	11	1	3	3.4	CCN(CC)CCOCCNCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		16125371	91534	0	None	-28	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
		CHEMBL223017	91534	0	None	-28	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
		53324553	63629	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		CHEMBL1643900	63629	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
		53324553	63629	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		CHEMBL1643900	63629	0	None	-3	10	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
		11013666	66206	1	None	-5	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	354	6	0	2	5.2	CN(C)CCC1=C(C(c2ccccc2)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL171102	66206	1	None	-5	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	354	6	0	2	5.2	CN(C)CCC1=C(C(c2ccccc2)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		44593616	199993	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL523518	199993	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		162649767	186881	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4748337	186881	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	333	4	1	3	4.0	Cn1ccc2c(NC(=O)CCN3CCCc4ccccc43)cccc21	10.1016/j.bmcl.2020.127632
		44448500	19106	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185248	19106	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL402282	19106	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	549	12	2	3	6.2	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		145961152	168370	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4129382	168370	0	None	-1	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		162658112	187850	0	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
		CHEMBL4759774	187850	0	None	-1	4	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	393	2	0	5	4.0	CC(C)(C)OC(=O)N1CCN(CC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.bmcl.2020.127632
		73347827	99319	0	None	1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	311	4	0	2	2.6	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432052	99319	0	None	1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	311	4	0	2	2.6	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		14964494	18729	1	None	2	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118292	18729	1	None	2	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL5287315	201158	0	None	-12	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	460	8	1	3	6.5	C#CCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		1734	6904	10	None	-9	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		307	6904	10	None	-9	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		CHEMBL168067	6904	10	None	-9	13	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHOK1 cells after 2 hrs	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/j.bmcl.2013.01.025
		214124	176470	2	None	-5	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL443780	176470	2	None	-5	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		164619478	195318	0	None	15	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4872882	195318	0	None	15	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028552	195318	0	None	15	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	533	8	3	7	1.5	NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		14210083	163491	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		CHEMBL4070155	163491	1	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		137629887	167789	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4065555	167789	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116259	167789	0	None	-3	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	218	4	0	1	3.1	C[N+](C)(C)CCCc1ccc2ccoc2c1	10.1021/acs.jmedchem.7b01113
		14964507	121132	1	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL333107	121132	1	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		2551	7581	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		298	7581	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		488	7581	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL965	7581	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		DB00411	7581	23	None	-3	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		13326	7838	0	None	-2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis	ChEMBL	321	3	2	6	2.7	CC1=CC(=NC(NC2=C(C=CC=C2)C3=NN=NN3)=N1)C(F)(F)F	10.1021/acs.jmedchem.2c01997
		CHEMBL5279691	7838	0	None	-2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysisDisplacement of [3H]NMS from human M2 receptor stably expressed in HEK293T cells by Cheng-Prusoff equation analysis	ChEMBL	321	3	2	6	2.7	CC1=CC(=NC(NC2=C(C=CC=C2)C3=NN=NN3)=N1)C(F)(F)F	10.1021/acs.jmedchem.2c01997
		10716120	45057	0	None	-208	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@@H](F)C2)CC1	10.1021/jm0003135
		CHEMBL146249	45057	0	None	-208	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	402	7	2	3	3.9	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@@H](F)C2)CC1	10.1021/jm0003135
		44364174	128763	0	None	-128	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	400	7	3	4	3.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](O)C2)CC1	10.1021/jm0003135
		CHEMBL359220	128763	0	None	-128	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	400	7	3	4	3.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)[C@H]2CC[C@H](O)C2)CC1	10.1021/jm0003135
		2726	7706	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	7706	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	7706	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	7706	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	7706	68	None	-79	72	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		10880435	65833	0	None	6	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL169494	65833	0	None	6	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		11015312	12046	0	None	-34	5	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.9	CCCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL106505	12046	0	None	-34	5	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	5	1	5	4.9	CCCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		44448538	19191	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185855	19191	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL436850	19191	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	339	6	1	2	3.1	C[N+]1(C)CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		44267740	105098	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	500	7	0	4	6.4	COc1cccc(Cl)c1C(=O)N1CCC(N2CCC(Cc3ccc(SC(C)C)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
		CHEMBL274999	105098	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	500	7	0	4	6.4	COc1cccc(Cl)c1C(=O)N1CCC(N2CCC(Cc3ccc(SC(C)C)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
		1353	8692	93	None	-338	85	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		3559	8692	93	None	-338	85	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		86	8692	93	None	-338	85	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		CHEMBL54	8692	93	None	-338	85	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		DB00502	8692	93	None	-338	85	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm970333f
		155565286	183045	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4579642	183045	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595003	183045	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	760	18	6	8	2.7	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		156012936	185075	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4639004	185075	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650969	185075	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccccc2)[C@@H](c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		11092603	11633	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	524	7	0	7	5.8	C=CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL104332	11633	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	524	7	0	7	5.8	C=CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		73355325	99042	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426671	99042	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
		137642607	165297	0	None	-1230	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	348	5	0	2	4.2	O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4091231	165297	0	None	-1230	8	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	348	5	0	2	4.2	O=C1CCc2ccccc2N1CCCN1CCC(c2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		9817231	165015	22	None	-2	7	Human	4.6	pKi	=	4.6	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
		CHEMBL4088272	165015	22	None	-2	7	Human	4.6	pKi	=	4.6	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	282	4	0	3	4.1	CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1	10.1038/s41586-020-2286-9
		10693031	127765	0	None	-11	3	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	4	4.2	Cc1cc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cs1	10.1021/jm0003135
		CHEMBL356305	127765	0	None	-11	3	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	4	4.2	Cc1cc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cs1	10.1021/jm0003135
		15678851	109450	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	478	11	2	6	3.6	NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL304582	109450	0	None	1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	478	11	2	6	3.6	NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		15888010	210625	0	None	-79	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.3	NC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL68584	210625	0	None	-79	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	338	3	2	3	2.3	NC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		14964498	20659	0	None	6	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119615	20659	0	None	6	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		15050941	210446	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	427	4	1	5	3.1	O=C1Nc2cccnc2N(C(=O)CN2CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL67381	210446	0	None	-1	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	427	4	1	5	3.1	O=C1Nc2cccnc2N(C(=O)CN2CCN(Cc3ccccc3)CC2)c2ccccc21	10.1021/jm00111a032
		2230	7253	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
		296	7253	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
		CHEMBL7303	7253	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
		DB04365	7253	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm020572p
		137630995	167920	0	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4102555	167920	0	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117268	167920	0	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	4	0	2	1.6	COc1cccc(C(=O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		44328347	214330	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	317	1	1	2	3.6	OC1(C2=CN3CCC2CC3)c2ccccc2CCc2ccccc21	10.1016/S0960-894X(01)80824-6
		CHEMBL94772	214330	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	317	1	1	2	3.6	OC1(C2=CN3CCC2CC3)c2ccccc2CCc2ccccc21	10.1016/S0960-894X(01)80824-6
		44318817	175893	0	None	-7	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		CHEMBL440138	175893	0	None	-7	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	197	2	0	3	1.6	CCC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		10836338	46107	0	None	-186	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	429	6	2	4	3.5	O=C(NC1CCN(Cc2ccccn2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147105	46107	0	None	-186	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	429	6	2	4	3.5	O=C(NC1CCN(Cc2ccccn2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		10573458	126040	0	None	-218	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	407	6	2	4	3.5	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)n1	10.1021/jm0003135
		CHEMBL343659	126040	0	None	-218	3	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	407	6	2	4	3.5	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)n1	10.1021/jm0003135
		14537192	107000	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
		CHEMBL288482	107000	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	428	9	1	6	3.6	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
		44267796	104877	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc5ccccc5c4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL273439	104877	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	486	6	0	3	6.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccc5ccccc5c4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44326538	20038	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	9	0	3	4.3	CCN(CC)CCOC(=O)C(CC)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL1191560	20038	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	9	0	3	4.3	CCN(CC)CCOC(=O)C(CC)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		164622564	195340	0	None	25	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862221	195340	0	None	25	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028706	195340	0	None	25	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	902	21	9	12	0.2	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		2230	7253	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		296	7253	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		CHEMBL7303	7253	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		DB04365	7253	60	None	-75	10	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1016/j.bmc.2007.12.036
		164614732	195277	0	None	10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4860752	195277	0	None	10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028266	195277	0	None	10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	519	7	3	7	1.1	NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		162353371	188429	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4775999	188429	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	CC1CCc2ccccc2N1CC(=O)N1CCCC1	10.1016/j.bmcl.2020.127632
		10916286	11874	0	None	-1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cccc(Cl)c2C1O3	10.1021/jm011116o
		CHEMBL105593	11874	0	None	-1	4	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cccc(Cl)c2C1O3	10.1021/jm011116o
		15157141	99576	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	373	11	0	3	5.6	CCN(CC)CCCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL24369	99576	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	373	11	0	3	5.6	CCN(CC)CCCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		71449188	86460	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@H]1CCCN1	10.1021/jm00087a008
		CHEMBL2115359	86460	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@H]1CCCN1	10.1021/jm00087a008
		15157140	106650	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	359	10	0	3	5.2	CCN(CC)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL285898	106650	0	None	-2	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	359	10	0	3	5.2	CCN(CC)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		1210	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		1213	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		2725	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		33036	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		4411	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		616	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		6976	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		716121	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1201353	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL1554789	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		CHEMBL505	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB01114	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		DB13679	7705	51	None	-257	21	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	nan
		9880462	79679	0	None	-39	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	327	5	1	3	3.2	CCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
		CHEMBL200416	79679	0	None	-39	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	327	5	1	3	3.2	CCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
		9308	24526	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL1255785	24526	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL12587	24526	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL292911	24526	21	None	2	7	Human	7.6	pKi	=	7.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		10066369	127036	0	None	8	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL352375	127036	0	None	8	6	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		10269504	141151	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL371734	141151	0	None	-6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	353	3	1	3	3.6	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		44319342	212497	0	None	-31	2	Human	7.6	pKi	=	7.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL82512	212497	0	None	-31	2	Human	7.6	pKi	=	7.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	454	5	0	3	5.8	O=C(c1cccs1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		511332	116405	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
		CHEMBL322251	116405	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
		44267694	19499	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	512	7	0	3	7.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4-c4ccccc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11877	19499	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	512	7	0	3	7.4	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4-c4ccccc4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		511332	116405	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL322251	116405	5	None	-35	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1cc[n+]([O-])c(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		135409468	8816	69	None	-114	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
		333	8816	69	None	-114	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
		CHEMBL845	8816	69	None	-114	39	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1021/jm100697g
		464036	16518	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
		CHEMBL113436	16518	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1021/jm0155401
		14964506	120093	1	None	-6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL331556	120093	1	None	-6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		464036	16518	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL113436	16518	4	None	-1174	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	502	4	0	4	5.5	Cc1ccnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10012596	195793	2	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		CHEMBL50898	195793	2	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		1353	8692	93	None	-338	85	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		3559	8692	93	None	-338	85	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		86	8692	93	None	-338	85	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		CHEMBL54	8692	93	None	-338	85	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		DB00502	8692	93	None	-338	85	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by quinuclidinyl binding assay.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		15050947	109374	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	613	8	3	8	3.4	CC(C)(C)OC(=O)NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		CHEMBL304109	109374	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	613	8	3	8	3.4	CC(C)(C)OC(=O)NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		44406572	79617	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200208	79617	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	347	3	1	3	3.0	CO[C@@]1(C#CC(O)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406346	142928	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	361	4	1	3	3.2	COC1(C#CC(O)(Cc2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL373256	142928	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	361	4	1	3	3.2	COC1(C#CC(O)(Cc2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		2200	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		328	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		4848	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		CHEMBL9967	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		DB00670	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(96)00107-2
		164611279	195252	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4854472	195252	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028067	195252	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	832	19	12	11	-1.4	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44319010	212605	0	None	-15	2	Human	6.6	pKi	=	6.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	348	5	0	2	4.5	O=C(C1CCC1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL83363	212605	0	None	-15	2	Human	6.6	pKi	=	6.6	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	348	5	0	2	4.5	O=C(C1CCC1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		50898777	63214	0	None	-23442	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2Binding affinity to muscarinic acetylcholine receptor M2	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		CHEMBL1632158	63214	0	None	-23442	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2Binding affinity to muscarinic acetylcholine receptor M2	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
		15050950	210836	0	None	-3	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	5	2	6	1.1	CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL70003	210836	0	None	-3	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	5	2	6	1.1	CC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		44267715	21316	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	438	6	0	5	4.5	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnccn4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12029	21316	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	438	6	0	5	4.5	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnccn4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		462989	39878	1	None	-14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1c[n+]([O-])cc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL141699	39878	1	None	-14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	518	4	0	4	4.7	Cc1c[n+]([O-])cc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		44267750	22020	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	6	0	5	5.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12112	22020	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	6	0	5	5.7	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cnnc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44267697	23089	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cccnc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12268	23089	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	487	6	0	4	6.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5cccnc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		11011757	65997	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	291	5	0	1	4.8	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccc1	10.1021/jm020895l
		CHEMBL170221	65997	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	291	5	0	1	4.8	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccc1	10.1021/jm020895l
		10104167	8840	2	None	13	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	8840	2	None	13	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	8840	2	None	13	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		44448496	18684	0	None	-3	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182637	18684	0	None	-3	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL257547	18684	0	None	-3	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	401	7	1	2	4.7	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCN(c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		15157139	106587	0	None	-8	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CN(C)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL285440	106587	0	None	-8	4	Human	6.6	pKi	=	6.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	331	8	0	3	4.4	CN(C)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		44267751	105162	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	7	1	4	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Cc3ccc(SCCO)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
		CHEMBL275347	105162	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	488	7	1	4	5.5	O=C(c1cccc2ccccc12)N1CCC(N2CCC(Cc3ccc(SCCO)cc3)CC2)CC1	10.1016/s0960-894x(02)00096-3
		154734599	9281	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		327	9281	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		4108	9281	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		CHEMBL27673	9281	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Binding affinity to human muscarinic M2 receptor by radioligand displacement assayBinding affinity to human muscarinic M2 receptor by radioligand displacement assay	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1016/j.ejmech.2013.01.044
		44383065	127158	0	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	399	5	1	3	5.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCNC34CC5CC(CC(C5)C3)C4)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL353311	127158	0	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	399	5	1	3	5.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCNC34CC5CC(CC(C5)C3)C4)[C@@H]12	10.1016/s0960-894x(99)00101-8
		44312152	210925	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	374	6	1	5	2.2	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(CCO)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL70531	210925	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	374	6	1	5	2.2	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(CCO)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL5268503	200346	0	None	-10	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1038	20	1	13	9.7	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
		CHEMBL5283759	201007	0	None	-7	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1024	19	1	13	9.4	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
		15678850	109785	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	464	10	2	6	3.2	NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL306875	109785	0	None	-1	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	464	10	2	6	3.2	NCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		15157137	106671	0	None	-17	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	317	7	0	3	4.0	CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		CHEMBL286008	106671	0	None	-17	4	Human	7.6	pKi	=	7.6	Binding	Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	317	7	0	3	4.0	CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1	10.1021/jm00085a017
		71741394	127613	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323287	127613	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558239	127613	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	576	13	0	5	4.9	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		44267799	23122	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	454	6	0	3	5.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4F)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12291	23122	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	454	6	0	3	5.9	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4F)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		14964499	176168	3	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL442206	176168	3	None	-	1	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	CC1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		10421982	212820	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
		CHEMBL85190	212820	0	None	1	4	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	245	2	0	3	2.5	CN1C2CCCC1C(OC(=O)c1ccccc1)C2	10.1021/jm9904001
		10812455	46561	0	None	-109	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	428	6	2	3	4.1	O=C(NC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147653	46561	0	None	-109	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	428	6	2	3	4.1	O=C(NC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		15196354	126048	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
		CHEMBL343697	126048	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	0	1	2.5	C[N+]12CCC(CC1)C(C1Cc3ccccc3O1)C2	10.1021/jm00003a011
		23352285	103554	2	None	-2	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	219	2	0	3	2.6	O=Cc1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
		CHEMBL264747	103554	2	None	-2	3	Human	5.6	pKi	=	5.6	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	219	2	0	3	2.6	O=Cc1ccc(C2=CN3CCC2CC3)s1	10.1016/S0960-894X(01)80824-6
		137628850	167748	0	None	-1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4097248	167748	0	None	-1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4115965	167748	0	None	-1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1CC[N+](C)(C)C2	10.1021/acs.jmedchem.7b01113
		10957754	65818	0	None	2	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CC(C1=C(CCCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL169401	65818	0	None	2	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CC(C1=C(CCCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		46905988 91930079	17188	0	None	-3	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	8	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(CCCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL1162964	17188	0	None	-3	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	8	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(CCCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		15050946	109423	0	None	1	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	484	5	2	6	2.5	CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		CHEMBL304391	109423	0	None	1	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	484	5	2	6	2.5	CNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		1212	8443	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	8443	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	8443	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	8443	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	8443	50	None	-1380	65	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		2200	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		328	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		4848	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		CHEMBL9967	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		DB00670	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenateAbility to displace [3H](-)-quinuclidinyl benzilate(QNB) from M2 receptor in rat heart homogenate	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00059a009
		2200	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		328	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		4848	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		CHEMBL9967	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		DB00670	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00114a005
		2200	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		328	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		4848	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		CHEMBL9967	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		DB00670	9905	46	None	-31	13	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/S0960-894X(97)00143-1
		13773340	86365	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2114396	86365	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		16125698	91331	0	None	-102	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2ccccn2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222054	91331	0	None	-102	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	477	6	1	3	3.7	C[N+]1(CC(=O)c2ccccn2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		70682037	82656	20	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
		CHEMBL2048820	82656	20	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
		3652	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		57	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		60809	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		CHEMBL21536	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		DB15357	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		24894637	195498	0	None	2	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL504733	195498	0	None	2	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		CHEMBL553434	195498	0	None	2	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	180	1	0	1	2.5	Cc1ccc([C@H]2CCC[N+]2(C)C)o1	10.1021/jm800145d
		44296020	201614	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	487	6	2	4	4.3	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]cnc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL53965	201614	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	487	6	2	4	4.3	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5[nH]cnc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		154734599	9281	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
		327	9281	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
		4108	9281	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
		CHEMBL27673	9281	12	None	1	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cellsDisplacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm401895u
		156578	148267	5	None	81	2	Rat	7.6	pKi	=	7.6	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	192	2	0	2	0.3	O=C1CCCN1CC#CCN1CCC1	10.1021/jm00087a008
		CHEMBL38441	148267	5	None	81	2	Rat	7.6	pKi	=	7.6	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	192	2	0	2	0.3	O=C1CCCN1CC#CCN1CCC1	10.1021/jm00087a008
		16125335	144936	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	454	6	1	2	4.3	C[N+]1(C[C@H]2O[C@@H]2c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL376900	144936	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	454	6	1	2	4.3	C[N+]1(C[C@H]2O[C@@H]2c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		462772	109088	1	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	643	6	0	7	5.9	C[C@H]1CN(C2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		CHEMBL303503	109088	1	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	643	6	0	7	5.9	C[C@H]1CN(C2CCN(C(=O)c3c(Cl)cccc3Cl)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		44385809	68240	0	None	-81	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL177040	68240	0	None	-81	5	Human	6.6	pKi	=	6.6	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		2200	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		328	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		4848	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		CHEMBL9967	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		DB00670	9905	46	None	-35	13	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00003a011
		9991939	126130	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2cc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL344327	126130	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2cc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
		11796509	47471	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	422	7	2	4	3.9	COc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
		CHEMBL148450	47471	0	None	-45	3	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	422	7	2	4	3.9	COc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
		10354430	43945	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	243	1	1	3	2.3	OC1(c2cc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL145301	43945	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	243	1	1	3	2.3	OC1(c2cc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
		9839491	169988	0	None	1	3	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
		CHEMBL41830	169988	0	None	1	3	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
		CHEMBL554874	169988	0	None	1	3	Rat	5.6	pKi	=	5.6	Binding	Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartCompound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart	ChEMBL	305	2	0	2	4.1	O=C1c2ccccc2CCC12CCN(Cc1ccccc1)CC2	10.1021/jm970740r
		10035281	107759	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		CHEMBL294273	107759	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		10035281	107759	0	None	-1	8	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
		CHEMBL294273	107759	0	None	-1	8	Rat	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
		10035281	107759	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
		CHEMBL294273	107759	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9705115
		14964506	120093	1	None	-6	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL331556	120093	1	None	-6	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		15196232	172150	3	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2cccnc2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL423746	172150	3	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	204	1	1	3	1.0	OC1(c2cccnc2)CN2CCC1CC2	10.1021/jm00003a011
		137628858	167750	0	None	1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4074319	167750	0	None	1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115967	167750	0	None	1	3	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	CCOc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		3055	8215	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		313	8215	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		7163	8215	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		CHEMBL936	8215	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		DB01231	8215	44	None	-2	9	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	nan
		44384258	135452	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.6	CC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
		CHEMBL366819	135452	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.6	CC1CCCCN1CCC[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@@H](C)[C@@H]21	10.1016/s0960-894x(99)00101-8
		3652	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	10869	79	None	-18	18	Human	6.6	pKi	=	6.6	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60138186	127614	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	127614	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	127614	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	127614	0	None	23	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		11504244	113296	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	113296	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	113296	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	113296	0	None	199	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		44448646	18680	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182612	18680	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
		CHEMBL254586	18680	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	1	4.3	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCCCC1	10.1016/j.bmcl.2008.03.061
		10035281	107759	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1016/j.bmc.2007.12.036
		CHEMBL294273	107759	0	None	-1	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1016/j.bmc.2007.12.036
		46227483	20897	0	None	-1	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198039	20897	0	None	-1	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL593685	20897	0	None	-1	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		9868297	100889	0	None	-13	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249205	100889	0	None	-13	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		1016	10519	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	10519	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	10519	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	10519	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	10519	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	10519	78	None	-23	35	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		73347826	99317	0	None	-2	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	266	4	1	2	2.4	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)nc1	10.1016/j.bmc.2013.07.045
		CHEMBL2432049	99317	0	None	-2	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	266	4	1	2	2.4	c1ccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)nc1	10.1016/j.bmc.2013.07.045
		3191	109635	97	None	-8	25	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	109635	97	None	-8	25	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		44308861	210307	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	316	4	2	3	2.3	NCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL66400	210307	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	316	4	2	3	2.3	NCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		44404147	175869	12	None	-19	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL439867	175869	12	None	-19	3	Rat	7.6	pKi	=	7.6	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL5282659	200946	0	None	-14	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	465	9	2	4	5.8	NCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		11968014	19530	5	None	-4	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	19530	5	None	-4	9	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		24936155	101397	0	None	-46	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	508	4	2	3	5.1	CC(=O)N1C2C=C(CN3C4CCC3CC(NC(=O)Nc3cc(F)cc(C(F)(F)F)c3)C4)CC1CCC2	10.1016/j.bmcl.2007.10.109
		CHEMBL252258	101397	0	None	-46	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	508	4	2	3	5.1	CC(=O)N1C2C=C(CN3C4CCC3CC(NC(=O)Nc3cc(F)cc(C(F)(F)F)c3)C4)CC1CCC2	10.1016/j.bmcl.2007.10.109
		44309151	210362	0	None	-60	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.3	NCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL66820	210362	0	None	-60	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.3	NCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		10103909	210083	3	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2cccnc2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL64779	210083	3	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	186	1	0	2	2.1	C1=C(c2cccnc2)C2CCN1CC2	10.1021/jm00003a011
		275176	96588	1	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.4	CCN(CC)CCOC(=O)C(O)(c1ccccc1)c1c(C)cccc1C	10.1016/j.bmc.2013.01.072
		CHEMBL2377388	96588	1	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.4	CCN(CC)CCOC(=O)C(O)(c1ccccc1)c1c(C)cccc1C	10.1016/j.bmc.2013.01.072
		3055	8215	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		313	8215	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		7163	8215	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		CHEMBL936	8215	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		DB01231	8215	44	None	-2	9	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1016/j.bmcl.2008.03.061
		67407161	99059	0	None	-1819	2	Human	4.6	pKi	=	4.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426688	99059	0	None	-1819	2	Human	4.6	pKi	=	4.6	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		57326237	83958	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042407	83958	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078985	83958	0	None	-7	5	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		44384326	66650	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC1	10.1016/s0960-894x(99)00101-8
		CHEMBL172969	66650	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC1	10.1016/s0960-894x(99)00101-8
		109013312	186913	1	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4748774	186913	1	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	3	0	2	2.5	O=C(CCN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		11530307	85117	0	None	1	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2093082	85117	0	None	1	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2109993	85117	0	None	1	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		7141654	182568	8	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@@H]2CCCN2)o1	10.1021/jm800145d
		CHEMBL458416	182568	8	None	-	1	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@@H]2CCCN2)o1	10.1021/jm800145d
		180	7189	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	7189	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	7189	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	7189	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	7189	56	None	-27	40	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		44627739	205151	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	333	4	1	3	4.3	CN1CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL576663	205151	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	333	4	1	3	4.3	CN1CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		44308818	108858	0	None	-30	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1cccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)c1	10.1016/s0960-894x(03)00350-0
		CHEMBL302145	108858	0	None	-30	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1cccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)c1	10.1016/s0960-894x(03)00350-0
		14964495	19385	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118700	19385	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		199230	169914	21	None	37	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		CHEMBL41779	169914	21	None	37	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		137630127	167828	0	None	-2	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4084607	167828	0	None	-2	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116537	167828	0	None	-2	3	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	210	4	1	2	1.4	COc1cccc(C(O)C[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		16125443	91424	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	335	3	1	2	3.1	CN1CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061159a
		CHEMBL222402	91424	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	335	3	1	2	3.1	CN1CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)CC1	10.1021/jm061159a
		44274400	105714	0	None	-1	5	Human	4.5	pKi	=	4.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL279520	105714	0	None	-1	5	Human	4.5	pKi	=	4.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		3675988	183614	66	None	-2	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc(C2CCCN2)c1	10.1021/jm800145d
		CHEMBL461087	183614	66	None	-2	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc(C2CCCN2)c1	10.1021/jm800145d
		16125437	91123	0	None	-19	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	4.9	O=C1NC(Cc2ccccc2)(Cc2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL221713	91123	0	None	-19	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	439	7	1	2	4.9	O=C1NC(Cc2ccccc2)(Cc2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		16125568	104105	0	None	-17	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccc(Cl)cc2)CC1	10.1021/jm061159a
		CHEMBL269280	104105	0	None	-17	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccc(Cl)cc2)CC1	10.1021/jm061159a
		7333	106133	79	None	-3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	239	2	3	1	3.8	Cc1ccccc1NC(=N)Nc1ccccc1C	10.1021/jm00039a008
		CHEMBL282433	106133	79	None	-3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	239	2	3	1	3.8	Cc1ccccc1NC(=N)Nc1ccccc1C	10.1021/jm00039a008
		1530	8963	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	8963	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	8963	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	8963	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	8963	50	None	-43	21	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		10410916	100845	0	None	-9	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	438	7	2	3	4.0	O=C(N[C@H]1[C@@H]2CN(CCc3ccc(Cl)cc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249007	100845	0	None	-9	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	438	7	2	3	4.0	O=C(N[C@H]1[C@@H]2CN(CCc3ccc(Cl)cc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		44378598	64911	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1c(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)ccc2c1OCO2	10.1016/s0960-894x(02)00024-0
		CHEMBL167838	64911	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1c(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)ccc2c1OCO2	10.1016/s0960-894x(02)00024-0
		156014820	185084	0	None	3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4646116	185084	0	None	3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4650998	185084	0	None	3	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	780	14	1	6	7.8	Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1021/acs.jmedchem.9b02172
		11968014	19530	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	19530	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		10225340	211113	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	441	6	0	5	4.8	COc1ccc(S(=O)(=O)c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL71531	211113	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	441	6	0	5	4.8	COc1ccc(S(=O)(=O)c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		174174	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		25034182	179363	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
		CHEMBL448870	179363	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
		CHEMBL540359	179363	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assayDisplacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 by scintillation proximity assay	ChEMBL	589	10	5	6	4.3	CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1	10.1021/jm800634k
		25010559	103544	0	None	-10	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL264676	103544	0	None	-10	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		9936450	41929	0	None	-4	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	518	14	0	10	5.0	CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm501173q
		CHEMBL143469	41929	0	None	-4	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	518	14	0	10	5.0	CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1	10.1021/jm501173q
		44406597	79684	0	None	-12	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	339	3	1	3	3.2	COC1(C#CC(O)(c2ccccc2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200432	79684	0	None	-12	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	339	3	1	3	3.2	COC1(C#CC(O)(c2ccccc2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406686	147689	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL382213	147689	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2cccnc2F)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44382699	65914	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	6	0	8	4.1	CC(C)OC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL169876	65914	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	530	6	0	8	4.1	CC(C)OC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		129989	7239	51	None	1	9	Rat	8.5	pKi	=	8.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
		8584	7239	51	None	1	9	Rat	8.5	pKi	=	8.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
		CHEMBL43383	7239	51	None	1	9	Rat	8.5	pKi	=	8.5	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00046a021
		44292486	188290	0	None	-	1	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		CHEMBL47650	188290	0	None	-	1	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	369	5	1	4	3.0	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(CF)cc1	10.1021/jm00010a016
		11968014	19530	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	19530	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		11968014	19530	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	19530	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		118710670	127611	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	127611	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	127611	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		16115801	19067	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL1184882	19067	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL375851	19067	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	340	3	0	2	4.3	C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		9883040	107313	0	None	-8	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		CHEMBL291339	107313	0	None	-8	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		CHEMBL542622	107313	0	None	-8	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	307	8	0	5	3.2	CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2	10.1016/s0960-894x(99)00313-3
		156011965	184071	0	None	-51	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	380	4	2	3	4.8	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OCC1CCNCC1	10.1021/acs.jmedchem.2c01376
		CHEMBL4636528	184071	0	None	-51	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	380	4	2	3	4.8	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OCC1CCNCC1	10.1021/acs.jmedchem.2c01376
		70685504	81229	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
		CHEMBL2021478	81229	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
		CHEMBL2027846	81229	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(CC(=O)N1c2ccccc2NC(=O)c2ccccc21)[C@H]1CCCC[C@H]1N(C)C	10.1016/j.bmc.2008.06.025
		11968014	19530	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		CHEMBL1187846	19530	5	None	-4	9	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm500790x
		164625419	195369	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4862087	195369	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028881	195369	0	None	5	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	504	8	2	6	3.0	NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		71461681	86315	0	None	5	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2114067	86315	0	None	5	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	425	6	0	4	5.1	COc1ccc([S@@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		59291461	119552	0	None	-17	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298334	119552	0	None	-17	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305613	119552	0	None	-17	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	328	3	1	4	4.2	O=C(Nc1cscc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		23983764	17105	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	3	0	5	1.3	Cc1nccn1CC#CCOc1ccon1	10.1016/j.bmc.2007.12.036
		CHEMBL1162116	17105	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	217	3	0	5	1.3	Cc1nccn1CC#CCOc1ccon1	10.1016/j.bmc.2007.12.036
		154417	100035	60	None	-18	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	100035	60	None	-18	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		1201549	7384	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		333	7384	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		7601	7384	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL1201203	7384	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		CHEMBL438151	7384	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		DB00245	7384	24	None	-5	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
		9892600	65270	0	None	-1	2	Rat	8.4	pKi	=	8.4	Binding	Inhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heartInhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	511	12	2	6	5.0	Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCN)CC1)c1ccccc1NC2=O	10.1016/S0960-894X(00)80542-9
		CHEMBL168329	65270	0	None	-1	2	Rat	8.4	pKi	=	8.4	Binding	Inhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heartInhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	511	12	2	6	5.0	Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCN)CC1)c1ccccc1NC2=O	10.1016/S0960-894X(00)80542-9
		14939897	103324	0	None	-2	4	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL1201994	103324	0	None	-2	4	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL262913	103324	0	None	-2	4	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	1113	33	2	12	12.0	COc1ccccc1CN(CCCCCCN(C)CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)Cc1ccccc1OC)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		44311761	109627	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		CHEMBL305607	109627	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/s0960-894x(00)00457-1
		9889312	85205	0	None	2	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	85205	0	None	2	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		9798900	69910	1	None	-26	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL1779047	69910	1	None	-26	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		CHEMBL1789446	69910	1	None	-26	3	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	322	3	1	3	4.1	O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2	10.1016/j.bmc.2014.04.031
		44311761	109627	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		CHEMBL305607	109627	0	None	15	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	496	7	0	5	4.7	C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)CC)CC2)CC1	10.1016/j.bmcl.2007.01.058
		1734	6904	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
		307	6904	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
		CHEMBL168067	6904	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00403-G
		69058946	113252	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084658	113252	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3140110	113252	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	336	4	1	1	4.3	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		44233192	113259	0	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084643	113259	0	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3140141	113259	0	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	350	5	1	1	4.4	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](CC(CO)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		70687661	81228	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2021476	81228	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2027845	81228	0	None	3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		1734	6904	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
		307	6904	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
		CHEMBL168067	6904	10	None	-12	13	Rat	8.4	pKi	=	8.4	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	10.1016/0960-894X(95)00113-8
		11039424	85691	1	None	-97	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	622	14	3	4	5.4	O=C(CCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112955	85691	1	None	-97	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	622	14	3	4	5.4	O=C(CCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		155529196	178189	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	4	0	3	4.4	Cc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
		CHEMBL4462631	178189	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	368	4	0	3	4.4	Cc1ccc(COC(=O)N(c2ccccc2)C2CN3CCC2CC3)cc1F	10.1016/j.bmcl.2018.12.022
		155554149	182226	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	4	0	5	3.7	O=C(OCc1ccc2c(c1)OCO2)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		CHEMBL4576768	182226	0	None	-1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	380	4	0	5	3.7	O=C(OCc1ccc2c(c1)OCO2)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		10500741	45320	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	392	6	2	3	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL146464	45320	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	392	6	2	3	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		10104	10339	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
		6604866	10339	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
		CHEMBL1493369	10339	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	10.1021/jm020895l
		132712	178577	19	None	5	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting method	ChEMBL	567	10	1	5	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccc(Cl)cc3C(=O)Nc3cccnc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4468100	178577	19	None	5	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K1 cells by scintillation counting method	ChEMBL	567	10	1	5	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccc(Cl)cc3C(=O)Nc3cccnc32)CC1	10.1021/acs.jmedchem.8b01967
		73353378	96577	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	331	4	1	4	2.4	CN1CCC(OC(=O)C(CO)c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2013.01.072
		CHEMBL2377268	96577	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	331	4	1	4	2.4	CN1CCC(OC(=O)C(CO)c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmc.2013.01.072
		44309231	176277	0	None	-301	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	2	3	3.7	CCC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL443267	176277	0	None	-301	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	6	2	3	3.7	CCC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44308913	210746	0	None	-19	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	381	4	2	4	0.9	NCC(=O)N1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL69402	210746	0	None	-19	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	381	4	2	4	0.9	NCC(=O)N1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		155511167	176337	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	432	6	0	3	5.7	O=C(OCCCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		CHEMBL4435641	176337	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	432	6	0	3	5.7	O=C(OCCCc1ccc(Cl)c(Cl)c1)N(c1ccccc1)C1CN2CCC1CC2	10.1016/j.bmcl.2018.12.022
		10105296	212701	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
		CHEMBL84113	212701	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	231	2	1	3	2.1	O=C(OC1CC2CCCC1N2)c1ccccc1	10.1021/jm9904001
		10244370	128303	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	260	1	1	4	2.2	OC1(c2nc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL358505	128303	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	260	1	1	4	2.2	OC1(c2nc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
		16086003	87206	0	None	-724	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		CHEMBL214642	87206	0	None	-724	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		14964497	21063	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119985	21063	0	None	-	1	Rat	4.5	pKi	=	4.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		15749863	161390	5	None	-3	2	Human	4.5	pKi	=	4.5	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	197	0	0	3	1.2	CC1(C)OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		CHEMBL39922	161390	5	None	-3	2	Human	4.5	pKi	=	4.5	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	197	0	0	3	1.2	CC1(C)OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		156009611	185036	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4634605	185036	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650698	185036	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		156015730	185095	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4644389	185095	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651081	185095	0	None	2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		16125508	91107	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	1	3	4.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccnc2)CC1	10.1021/jm061159a
		CHEMBL221660	91107	0	None	3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	1	3	4.0	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccnc2)CC1	10.1021/jm061159a
		16125680	143415	0	None	-70	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	429	5	1	2	4.8	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		CHEMBL373994	143415	0	None	-70	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	429	5	1	2	4.8	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(F)c2)CC1	10.1021/jm061159a
		44593621	200076	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524061	200076	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		611101	210658	3	None	-2	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	380	4	2	6	0.9	NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL68771	210658	3	None	-2	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	380	4	2	6	0.9	NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		10315426	107825	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL294663	107825	0	None	2	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	343	0	0	3	3.9	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](C#C[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		118710666	127607	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323282	127607	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558210	127607	0	None	-4	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		155559291	183438	0	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4563530	183438	0	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4598099	183438	0	None	3	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	689	16	5	7	3.2	CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		24894514	179513	3	None	1	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@H]1c1ccco1	10.1021/jm800145d
		CHEMBL450729	179513	3	None	1	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@H]1c1ccco1	10.1021/jm800145d
		463493	210415	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	575	6	0	7	4.3	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL67172	210415	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	575	6	0	7	4.3	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		44400323	75444	0	None	-2	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	361	5	1	4	2.4	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
		CHEMBL192065	75444	0	None	-2	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	361	5	1	4	2.4	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
		9859365	15269	2	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2cc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL109405	15269	2	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2cc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
		16125589	91474	0	None	-16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	6	1	2	4.1	C[N+]1(CC(=O)c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222636	91474	0	None	-16	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	440	6	1	2	4.1	C[N+]1(CC(=O)c2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		167962	10841	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	10841	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	10841	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]Dimethyl-W84 from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		44449463	102880	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL260228	102880	0	None	-12	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	381	3	1	3	4.3	CO[C@]1(C#C[C@@](O)(c2ccccc2)C2CCCCCCC2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		44627744	20812	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL1197389	20812	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL569729	20812	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	348	4	1	2	4.5	C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		167962	10841	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	10841	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	10841	4	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		6472	209526	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00114a005
		CHEMBL61946	209526	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00114a005
		44318736	113798	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
		CHEMBL315428	113798	0	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
		16086066	146013	0	None	-794	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		CHEMBL378872	146013	0	None	-794	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	710	9	3	5	5.4	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		10503358	45460	0	None	-354	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	442	6	2	3	4.4	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		CHEMBL146567	45460	0	None	-354	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	442	6	2	3	4.4	Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		10647703	127746	0	None	-123	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	461	6	3	4	3.8	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1F	10.1021/jm0003135
		CHEMBL356181	127746	0	None	-123	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	461	6	3	4	3.8	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1F	10.1021/jm0003135
		44318851	111503	0	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		CHEMBL310558	111503	0	None	-3	4	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	183	2	1	3	1.2	CCC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		10984804	105252	0	None	-30	2	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	592	9	2	4	4.5	O=C(NC[C@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		CHEMBL275914	105252	0	None	-30	2	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	592	9	2	4	4.5	O=C(NC[C@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		10835518	47101	0	None	-257	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	3	4.6	O=C(NC1CCN(CC2CCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL148129	47101	0	None	-257	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	412	6	2	3	4.6	O=C(NC1CCN(CC2CCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		44383554	127568	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C1	10.1016/s0960-894x(99)00101-8
		CHEMBL355475	127568	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	4	0	3	4.5	CC1CCCN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C1	10.1016/s0960-894x(99)00101-8
		44406476	147302	0	None	-15	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	326	3	1	4	2.2	COC1(C#CC(O)(c2ccccn2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL381020	147302	0	None	-15	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	326	3	1	4	2.2	COC1(C#CC(O)(c2ccccn2)C2CCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		9913892	212616	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL83459	212616	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	499	6	0	5	5.7	O=C(c1ccc([N+](=O)[O-])s1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44319006	212951	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	4.9	O=C(Cc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL86309	212951	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	4.9	O=C(Cc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		10044685	213112	6	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	370	5	0	2	5.0	O=C(c1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL87302	213112	6	None	-12	2	Human	6.5	pKi	=	6.5	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	370	5	0	2	5.0	O=C(c1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		10109893	88940	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
		CHEMBL216983	88940	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
		CHEMBL544840	88940	0	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	373	13	1	9	0.7	CN1CCC=C(c2nsnc2OCCOCCOCCOCCO)C1	10.1021/jm0606995
		44406342	78945	0	None	-5	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	5	1	3	3.3	COC1(C#CC(O)(Cc2ccccc2)Cc2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL197973	78945	0	None	-5	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	5	1	3	3.3	COC1(C#CC(O)(Cc2ccccc2)Cc2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		11536903	9176	68	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		3262	9176	68	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		CHEMBL3770346	9176	68	None	-6	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysisDisplacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins by scintillation counting analysis	ChEMBL	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1016/j.bmcl.2017.03.084
		10164480	50119	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	509	5	1	5	4.9	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
		CHEMBL150707	50119	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	509	5	1	5	4.9	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
		6472	209526	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligand	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		CHEMBL61946	209526	35	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor in rat using [3H]QN as radioligand	ChEMBL	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		9985181	127136	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	556	9	1	4	6.1	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
		CHEMBL353140	127136	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	556	9	1	4	6.1	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
		44383653	127629	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL355854	127629	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(99)00101-8
		10969390	66451	0	None	-4	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL172233	66451	0	None	-4	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	324	7	0	2	4.5	CC(C1=C(CCN(C)CCF)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		9843967	162237	1	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound to m2 muscarinic receptorBinding affinity of compound to m2 muscarinic receptor	ChEMBL	400	7	1	5	3.4	Nc1cccc(-c2ccc(CCN3CCN(CC(=O)c4ccccc4)CC3)cc2)n1	10.1016/s0960-894x(99)00432-1
		CHEMBL40391	162237	1	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity of compound to m2 muscarinic receptorBinding affinity of compound to m2 muscarinic receptor	ChEMBL	400	7	1	5	3.4	Nc1cccc(-c2ccc(CCN3CCN(CC(=O)c4ccccc4)CC3)cc2)n1	10.1016/s0960-894x(99)00432-1
		10092649	199852	56	None	-28	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1021/jm100697g
		CHEMBL522460	199852	56	None	-28	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	404	4	1	4	3.9	Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1	10.1021/jm100697g
		11794901	126361	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccccn2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL346194	126361	0	None	-22	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccccn2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		611066	164288	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	381	4	2	6	0.9	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCO)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL407975	164288	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	381	4	2	6	0.9	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCO)CC2)c2ccccc21	10.1021/jm00111a032
		10043954	89053	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21716	89053	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		302	9751	25	None	-34	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
		4630	9751	25	None	-34	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
		CHEMBL7634	9751	25	None	-34	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1016/j.bmc.2007.12.036
		3652	10869	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	10869	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	10869	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	10869	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	10869	79	None	-18	18	Human	6.5	pKi	=	6.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		164624458	195362	0	None	11	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4863121	195362	0	None	11	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028823	195362	0	None	11	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	873	19	9	12	-0.6	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164625211	195367	0	None	15	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4869865	195367	0	None	15	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028864	195367	0	None	15	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		171578	19076	5	None	-1	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
		CHEMBL1184962	19076	5	None	-1	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
		CHEMBL380759	19076	5	None	-1	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	281	3	1	2	2.6	C[N+](C)(C)CC#CCOC(=O)Nc1ccc(Cl)cc1	10.1021/jm0510878
		162353374	186822	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4747590	186822	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.2	CC1CCCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		118719925	122557	0	None	-43	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	330	7	1	3	2.8	O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1	10.1021/jm501173q
		CHEMBL3354072	122557	0	None	-43	8	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	330	7	1	3	2.8	O=C1CCc2ccccc2N1CCCN1CCC(CCCO)CC1	10.1021/jm501173q
		44627856	204268	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569953	204268	0	None	-2	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		290	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		4022	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		5926	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		CHEMBL40554	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		CHEMBL74300	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1021/jm800145d
		7141656	183616	7	None	3	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@H]2CCCN2)o1	10.1021/jm800145d
		CHEMBL461089	183616	7	None	3	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc([C@H]2CCCN2)o1	10.1021/jm800145d
		290	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		4022	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		5926	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		CHEMBL40554	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		CHEMBL74300	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmc.2009.10.027
		290	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		4022	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		5926	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		CHEMBL40554	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		CHEMBL74300	9251	6	None	-6	7	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	10.1016/j.bmcl.2014.06.020
		156015484	185070	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4645254	185070	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650952	185070	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc(-c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		11101362	11897	0	None	-8	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Cl)ccc2C1O3	10.1021/jm011116o
		CHEMBL105674	11897	0	None	-8	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	396	2	1	4	4.8	CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(Cl)ccc2C1O3	10.1021/jm011116o
		16125567	91533	0	None	-104	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		CHEMBL223016	91533	0	None	-104	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	445	5	1	2	5.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		16125507	172958	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	7	1	3	4.5	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCOc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL426393	172958	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	7	1	3	4.5	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCOc2ccccc2)CC1	10.1021/jm061159a
		44312464	211435	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	468	5	0	4	5.8	CC(c1ccc(S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL73661	211435	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	468	5	0	4	5.8	CC(c1ccc(S(=O)(=O)c2ccc(C(C)(C)C)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		11759212	64666	0	None	-40	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL167223	64666	0	None	-40	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2cc(Cl)ccc21)c1ccccn1	10.1021/jm020895l
		10316726	18800	0	None	-35	5	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		CHEMBL1183364	18800	0	None	-35	5	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		CHEMBL292857	18800	0	None	-35	5	Rat	7.5	pKi	=	7.5	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	364	2	0	3	3.6	C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1	10.1016/0960-894X(95)00403-G
		155554262	183334	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4582069	183334	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597244	183334	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	797	15	6	7	5.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		57326233	83961	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042406	83961	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079010	83961	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		145960466	168302	0	None	-7	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		CHEMBL4128341	168302	0	None	-7	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		10058649	42899	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	201	1	1	2	2.5	Oc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL144434	42899	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	201	1	1	2	2.5	Oc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
		10670917	171843	0	None	-102	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		CHEMBL422665	171843	0	None	-102	3	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	443	6	3	4	3.7	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		14964495	19385	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118700	19385	1	None	4	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		10739662	49050	0	None	-194	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	3	4.2	O=C(NC1CCN(CC2CCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL149769	49050	0	None	-194	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	3	4.2	O=C(NC1CCN(CC2CCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		10066972	105530	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL278074	105530	0	None	3	5	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2ccncc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		109035013	187254	1	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
		CHEMBL4752973	187254	1	None	1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	1	2	4.1	O=C(CCN1CCCc2ccccc21)Nc1ccc(Cl)cc1	10.1016/j.bmcl.2020.127632
		162353383	189356	0	None	2	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
		CHEMBL4787944	189356	0	None	2	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	284	4	1	4	2.2	Cn1ccc(NC(=O)CCN2CCCc3ccccc32)n1	10.1016/j.bmcl.2020.127632
		71449073	85357	0	None	-8	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	338	2	2	6	0.6	O=C1Nc2cccnc2N(C(=O)CN2CCNCC2)c2ncccc21	10.1021/jm00111a032
		CHEMBL2112217	85357	0	None	-8	4	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	338	2	2	6	0.6	O=C1Nc2cccnc2N(C(=O)CN2CCNCC2)c2ncccc21	10.1021/jm00111a032
		631645	171655	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	565	9	3	8	2.4	CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL422053	171655	1	None	1	3	Rat	5.5	pKi	=	5.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	565	9	3	8	2.4	CC(C)(C)OC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		44443731	100987	0	None	-36	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	7	2	3	3.4	O=C(N[C@H]1[C@@H]2CN(CCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249830	100987	0	None	-36	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	7	2	3	3.4	O=C(N[C@H]1[C@@H]2CN(CCc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		24882532	101892	0	None	-26	5	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
		CHEMBL255523	101892	0	None	-26	5	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from rat muscarinic M2 receptor expressed in CHO cells	ChEMBL	363	6	1	3	4.4	CCN1CCN(c2ccc(NC(=O)CCC3CCCC3)cc2Cl)CC1	10.1016/j.bmcl.2007.12.051
		10160073	117966	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL326450	117966	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		156015465	185103	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4640926	185103	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651115	185103	0	None	-1	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	344	5	0	3	4.0	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(Sc3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		46227485	20895	0	None	-3	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198034	20895	0	None	-3	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL593620	20895	0	None	-3	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		10160073	117966	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm301774u
		CHEMBL326450	117966	0	None	-338	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	434	6	1	5	5.1	CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm301774u
		10381417	75443	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		CHEMBL192061	75443	0	None	1	2	Rat	7.5	pKi	=	7.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		44312460	211400	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	344	4	0	4	2.8	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL73410	211400	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	344	4	0	4	2.8	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C)CC1	10.1016/s0960-894x(00)00438-8
		44382247	37274	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	634	7	0	8	5.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)c4cccc5ccccc45)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
		CHEMBL139311	37274	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	634	7	0	8	5.1	O=S(=O)(c1ccc(OC2CCN(C3CCN(S(=O)(=O)c4cccc5ccccc45)CC3)CC2)cc1)c1ccc2c(c1)OCO2	10.1016/s0960-894x(01)00100-7
		44325051	118474	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	546	8	0	7	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc([S+]([O-])c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328659	118474	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	546	8	0	7	3.7	CCCS(=O)(=O)N1CCC(N2CCC(C(=O)c3ccc([S+]([O-])c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		10623721	45125	0	None	-162	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	457	7	3	4	3.5	NCc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		CHEMBL146307	45125	0	None	-162	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	457	7	3	4	3.5	NCc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1	10.1021/jm0003135
		237	211644	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL546257	211644	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL554190	211644	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		CHEMBL7568	211644	48	None	-1	13	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	nan
		15050951	171704	0	None	1	2	Rat	4.5	pKi	=	4.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	493	8	3	7	0.6	CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL422407	171704	0	None	1	2	Rat	4.5	pKi	=	4.5	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	493	8	3	7	0.6	CC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		162353381	186808	0	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
		CHEMBL4747438	186808	0	None	-3	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	287	4	1	4	2.9	O=C(CCN1CCCc2ccccc21)Nc1nccs1	10.1016/j.bmcl.2020.127632
		462395	121980	1	None	-128	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	558	4	0	4	5.4	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)c[n+]([O-])cc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
		CHEMBL334470	121980	1	None	-128	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	558	4	0	4	5.4	C[C@H]1CN(C2(C)CCN(C(=O)c3c(Cl)c[n+]([O-])cc3Cl)CC2)CCN1[C@@H](C)c1ccc(C(F)(F)F)cc1	10.1016/s0960-894x(02)00918-6
		422063	202856	2	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377384	202856	2	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL560649	202856	2	None	-2	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	298	6	0	2	3.1	C[N+](C)(C)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		44443724	100764	0	None	-51	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.1	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL248614	100764	0	None	-51	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	418	6	2	3	4.1	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCCC1	10.1016/j.bmcl.2007.06.081
		456319	210855	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	539	6	0	5	5.7	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL70124	210855	1	None	-	1	Human	7.5	pKi	=	7.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	539	6	0	5	5.7	Cc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		44296053	196435	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	539	6	1	5	4.7	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccccc5Cl)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51515	196435	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	539	6	1	5	4.7	CC(C)NC(=O)c1ccc(C2(C3CCN(C4CCN(C(=O)c5ccccc5Cl)CC4)CC3)OCCO2)cc1	10.1016/j.bmcl.2004.01.033
		205895	18640	2	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		CHEMBL118240	18640	2	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		155565770	182403	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	410	7	0	5	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC	10.1016/j.bmcl.2018.12.022
		CHEMBL4580590	182403	0	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry methodDisplacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method	ChEMBL	410	7	0	5	4.0	COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC	10.1016/j.bmcl.2018.12.022
		11567493	208581	13	None	-15	3	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL606902	208581	13	None	-15	3	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
		461838	210427	1	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	611	6	0	7	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(F)cccc3F)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		CHEMBL67281	210427	1	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	611	6	0	7	4.9	C[C@H]1CN(C2CCN(C(=O)c3c(F)cccc3F)CC2)CCN1[C@@H](C)c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1	10.1016/s0960-894x(01)00381-x
		44382858	65990	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	333	4	0	3	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL170205	65990	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	333	4	0	3	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCCCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		145963288	168394	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		CHEMBL4129723	168394	0	None	-2	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		56672197	73336	0	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
		CHEMBL1824785	73336	0	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
		CHEMBL1852489	73336	0	None	-2	3	Human	5.5	pKi	=	5.5	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	245	2	0	1	3.6	Fc1cccc(CN2C3CC4CC(C3)CC2C4)c1	10.1016/j.bmcl.2011.07.028
		44450621	102607	0	None	3	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL258906	102607	0	None	3	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		57664406	9177	50	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		6938	9177	50	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089376	9177	50	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		162353375	186674	0	None	4	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4745885	186674	0	None	4	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	4	0	3	1.7	COC1CN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
		44448575	18689	0	None	-4	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182650	18689	0	None	-4	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL258161	18689	0	None	-4	5	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	324	6	1	3	3.0	CN1CCN(CCCC(O)(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2008.03.061
		73355419	99324	0	None	-3	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	4	0	2	2.7	CN(CCc1ccccn1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		CHEMBL2432059	99324	0	None	-3	5	Human	5.5	pKi	=	5.5	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	4	0	2	2.7	CN(CCc1ccccn1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
		44400800	172589	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	366	5	2	3	2.5	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL424832	172589	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	366	5	2	3	2.5	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
		44312455	211339	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	490	6	0	6	3.9	CC(c1ccc(S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL72956	211339	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	490	6	0	6	3.9	CC(c1ccc(S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cc1)N1CCN(C2CCCCC2)CC1	10.1016/s0960-894x(00)00438-8
		154734599	9281	12	None	1	12	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		327	9281	12	None	1	12	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		4108	9281	12	None	1	12	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		CHEMBL27673	9281	12	None	1	12	Human	7.4	pKi	=	7.4	Binding	Displacement of radiolabeled methoctramine from human muscarinic M2 receptorDisplacement of radiolabeled methoctramine from human muscarinic M2 receptor	ChEMBL	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	10.1021/jm8007618
		1687	111186	20	None	-15	5	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL310310	111186	20	None	-15	5	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL540034	111186	20	None	-15	5	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		44318736	113798	0	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
		CHEMBL315428	113798	0	None	-2	4	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	276	3	1	5	2.0	O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1	10.1021/jm9904001
		44318766	212530	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
		CHEMBL82754	212530	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
		44308798	210826	0	None	-19	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	434	6	1	3	4.4	O=C(N1CCC(CCN2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL69904	210826	0	None	-19	3	Human	4.4	pKi	=	4.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	434	6	1	3	4.4	O=C(N1CCC(CCN2CCCCC2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		10925451	65546	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2ccc(Cl)cc21)c1ccccn1	10.1021/jm020895l
		CHEMBL168707	65546	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	326	5	0	2	4.8	CC(C1=C(CCN(C)C)Cc2ccc(Cl)cc21)c1ccccn1	10.1021/jm020895l
		25067048	19105	0	None	-28	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185245	19105	0	None	-28	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL402207	19105	0	None	-28	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	646	13	2	2	8.1	C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		44627855	204150	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569212	204150	0	None	-1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		162353377	187944	0	None	2	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4760904	187944	0	None	2	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	2	0	2	2.8	CC1CCc2ccccc2N1CC(=O)N1CCCCC1	10.1016/j.bmcl.2020.127632
		162353372	188166	0	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
		CHEMBL4763422	188166	0	None	1	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.2	O=C(CCN1CCCc2ccccc21)N1CCCCC1CO	10.1016/j.bmcl.2020.127632
		71450996	86462	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL2115361	86462	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		10408304	110221	0	None	-11	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	393	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
		CHEMBL3084896	110221	0	None	-11	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	393	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1)C2	10.1021/jm00020a006
		13773342	86457	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2115341	86457	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		44312081	211026	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	330	4	1	4	2.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCNCC1	10.1016/s0960-894x(00)00438-8
		CHEMBL71088	211026	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	330	4	1	4	2.5	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCNCC1	10.1016/s0960-894x(00)00438-8
		2774	10640	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		5593	10640	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		7319	10640	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		CHEMBL1200604	10640	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		DB00809	10640	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		DB01199	10640	95	None	-1	10	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	nan
		10646948	44656	0	None	-30	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	4	3.8	O=C(NC1CCN(Cc2cccc(O)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL145913	44656	0	None	-30	3	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	4	3.8	O=C(NC1CCN(Cc2cccc(O)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		44379281	64320	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	506	9	1	5	5.3	CCOC(=O)N(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
		CHEMBL166385	64320	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	506	9	1	5	5.3	CCOC(=O)N(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
		10041771	110209	0	None	-13	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	321	4	0	2	4.7	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		CHEMBL3084881	110209	0	None	-13	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	321	4	0	2	4.7	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		16086004	146015	0	None	-1000	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		CHEMBL378885	146015	0	None	-1000	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	608	9	3	5	3.5	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1	10.1021/jm051205r
		25070031	72159	18	None	-1862	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	313	6	1	4	2.7	C[C@@H]1CCCN1CCCOc1ccc(-c2ccc(=O)[nH]n2)cc1	10.1021/jm200401v
		CHEMBL1829335	72159	18	None	-1862	4	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptorInhibition of muscarinic M2 receptor	ChEMBL	313	6	1	4	2.7	C[C@@H]1CCCN1CCCOc1ccc(-c2ccc(=O)[nH]n2)cc1	10.1021/jm200401v
		10397468	195743	2	None	-1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		CHEMBL50831	195743	2	None	-1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	C[C@H]1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		10501523	47295	0	None	-169	3	Human	4.4	pKi	=	4.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccccc1CN1CCC(NC(=O)C(O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
		CHEMBL148310	47295	0	None	-169	3	Human	4.4	pKi	=	4.4	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1ccccc1CN1CCC(NC(=O)C(O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
		10951142	11994	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	496	6	0	6	5.9	CCOC(=O)c1c(CC)n(Cc2ccccc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL106219	11994	0	None	-7	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	496	6	0	6	5.9	CCOC(=O)c1c(CC)n(Cc2ccccc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		24894628	185902	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
		CHEMBL471942	185902	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
		CHEMBL554532	185902	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCCC1c1ccco1	10.1021/jm800145d
		1273	8535	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		3450	8535	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		356	8535	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		6172	8535	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		67425	8535	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		CHEMBL360055	8535	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		DB00483	8535	16	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		24865895	102780	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL259662	102780	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL390842	102780	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2007.12.036
		1224	8214	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		3100	8214	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		8980	8214	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		916	8214	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		CHEMBL657	8214	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		DB01075	8214	83	None	-6	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
		44382840	127516	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	363	4	0	4	3.9	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC(C)O1	10.1016/s0960-894x(99)00101-8
		CHEMBL354934	127516	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	363	4	0	4	3.9	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)CC(C)O1	10.1016/s0960-894x(99)00101-8
		2200	9905	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		328	9905	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		4848	9905	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		CHEMBL9967	9905	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		DB00670	9905	46	None	-31	13	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00402a035
		44437227	18650	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
		CHEMBL1182447	18650	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
		CHEMBL239017	18650	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	194	3	0	4	0.9	Cc1cc(OCC#CCN(C)C)no1	10.1016/j.bmc.2007.09.003
		124087	8171	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		7157	8171	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		814	8171	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		CHEMBL1172	8171	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		DB00967	8171	114	None	-6	15	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
		100	10577	58	None	-19	54	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	10577	58	None	-19	54	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	10577	58	None	-19	54	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	10577	58	None	-19	54	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	10577	58	None	-19	54	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2733638	18686	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		6508731	18686	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		8030329	18686	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		CHEMBL1182640	18686	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		CHEMBL257643	18686	2	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	395	12	0	1	5.3	CCN(CC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		2551	7581	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		298	7581	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		488	7581	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		CHEMBL965	7581	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		DB00411	7581	23	None	-6	11	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm9904001
		44593620	194715	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496915	194715	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		187	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		10248845	129549	0	None	-3	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	374	6	0	3	3.1	CCN(CC)CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
		CHEMBL360491	129549	0	None	-3	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	374	6	0	3	3.1	CCN(CC)CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
		3652	10869	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	10869	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	10869	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	10869	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	10869	79	None	-18	18	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		187	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		14964507	121132	1	None	-5	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL333107	121132	1	None	-5	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		10443767	20654	1	None	-3	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
		CHEMBL1196108	20654	1	None	-3	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
		CHEMBL555955	20654	1	None	-3	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	228	1	0	4	1.4	CN1CCN(c2nncc3ccccc23)CC1	10.1021/jm9705418
		9911615	105807	0	None	-1905	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	5	0	6	5.5	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(SC)cc2CCN1C3	10.1021/jm011116o
		CHEMBL280220	105807	0	None	-1905	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	450	5	0	6	5.5	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(SC)cc2CCN1C3	10.1021/jm011116o
		44286172	151251	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	166	2	1	2	-0.2	CNCC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL39067	151251	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	166	2	1	2	-0.2	CNCC#CCN1CCCC1=O	10.1021/jm00087a008
		135	9310	43	None	-25	56	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	9310	43	None	-25	56	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	9310	43	None	-25	56	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	9310	43	None	-25	56	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	9310	43	None	-25	56	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		2284	9956	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	9956	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	9956	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	9956	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	9956	33	None	-21	29	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		108993425	188537	1	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4777543	188537	1	None	3	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	244	2	0	2	2.1	O=C(CN1CCCc2ccccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		44274477	172347	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	331	2	0	3	2.8	CN1CCN(C(=O)C2=C/C(=C\c3ccncc3)c3ccccc32)CC1	10.1016/s0960-894x(01)00186-x
		CHEMBL424214	172347	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	331	2	0	3	2.8	CN1CCN(C(=O)C2=C/C(=C\c3ccncc3)c3ccccc32)CC1	10.1016/s0960-894x(01)00186-x
		11595794	142479	0	None	-3	3	Rat	7.4	pKi	=	7.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
		CHEMBL372983	142479	0	None	-3	3	Rat	7.4	pKi	=	7.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	3	4.4	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1C1CCCCC1	10.1021/jm050099q
		59291324	119555	0	None	-4	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298593	119555	0	None	-4	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305622	119555	0	None	-4	3	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	329	3	1	5	3.5	O=C(Nc1scnc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		44443730	100808	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	6	2	3	4.7	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL248811	100808	0	None	-21	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	6	2	3	4.7	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		10340096	110210	0	None	-10	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	385	4	0	2	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
		CHEMBL3084882	110210	0	None	-10	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	385	4	0	2	5.2	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
		10269809	166160	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	345	3	0	2	4.1	COC1(C#CC(C)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL410061	166160	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	345	3	0	2	4.1	COC1(C#CC(C)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		44593616	199993	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL523518	199993	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		167962	10841	4	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		362	10841	4	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		CHEMBL31599	10841	4	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.6b01892
		44418764	88934	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
		CHEMBL216928	88934	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.8	COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1	10.1021/jm0606995
		16094791	90032	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL218755	90032	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	443	13	0	12	1.6	COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		16094783	143345	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL373888	143345	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	399	10	0	11	1.6	COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		15196234	125283	3	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccco2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL341476	125283	3	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	175	1	0	2	2.3	C1=C(c2ccco2)C2CCN1CC2	10.1021/jm00003a011
		3941250	20109	19	None	-70	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1192187	20109	19	None	-70	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
		CHEMBL543382	20109	19	None	-70	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	334	8	0	5	3.3	CCN(CC)CCOC(=O)C1(c2ccc([N+](=O)[O-])cc2)CCCC1	10.1021/jm00114a005
		187	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		294	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		65	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		8593	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL667	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB03128	7043	39	None	6	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		44309090	210528	0	None	-43	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	6	3	3	2.8	O=C(NCCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		CHEMBL67873	210528	0	None	-43	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	6	3	3	2.8	O=C(NCCC1CCNCC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1016/s0960-894x(03)00350-0
		137644950	165271	0	None	-1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	3	1.6	CN1CCC(COCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091032	165271	0	None	-1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	4	0	3	1.6	CN1CCC(COCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
		11099206	127565	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	318	5	0	2	4.7	CC(C1=C(CCN2CCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL355455	127565	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	318	5	0	2	4.7	CC(C1=C(CCN2CCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		44319008	212541	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	4	0	2	4.5	CC(=O)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL82850	212541	0	None	-2	2	Human	6.4	pKi	=	6.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	4	0	2	4.5	CC(=O)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44339685	117241	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		CHEMBL324725	117241	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		9978073	100843	0	None	-7	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	396	6	2	4	3.4	O=C(N[C@H]1[C@@H]2CN(Cc3cccs3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249005	100843	0	None	-7	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	396	6	2	4	3.4	O=C(N[C@H]1[C@@H]2CN(Cc3cccs3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		44448385	18682	0	None	-3	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182633	18682	0	None	-3	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL257174	18682	0	None	-3	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	406	7	1	3	4.8	CN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		44318781	113755	0	None	-5	2	Human	5.4	pKi	=	5.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	415	6	0	4	4.9	O=C(c1ccc([N+](=O)[O-])cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL315127	113755	0	None	-5	2	Human	5.4	pKi	=	5.4	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	415	6	0	4	4.9	O=C(c1ccc([N+](=O)[O-])cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		11759058	127627	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL355851	127627	0	None	1	5	Human	4.4	pKi	=	4.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		57326146	83962	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042403	83962	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079020	83962	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccccc2)O1	10.1021/jm2013216
		2551	7581	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		298	7581	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		488	7581	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL965	7581	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		DB00411	7581	23	None	-3	11	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		55005	111552	8	None	-1	3	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL310852	111552	8	None	-1	3	Rat	8.4	pKi	=	8.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		2705	10614	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		360	10614	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		443879	10614	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		CHEMBL1382	10614	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		DB01036	10614	64	None	-1	10	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.09.079
		44406662	173062	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2ccc(F)nc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL427013	173062	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	366	3	1	4	2.6	COC1(C#CC(O)(c2ccccc2)c2ccc(F)nc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44378914	126808	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
		CHEMBL350332	126808	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCN(C)CC1	10.1021/jm00001a002
		155560013	183079	0	None	6	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4564922	183079	0	None	6	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595198	183079	0	None	6	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	789	21	9	9	1.4	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		44593618	194238	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493979	194238	0	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		10073079	108297	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
		CHEMBL298085	108297	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
		16115798	144656	0	None	-3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL376255	144656	0	None	-3	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		155516383	183452	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4443219	183452	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4598230	183452	0	None	5	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		129989	7239	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		8584	7239	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		CHEMBL43383	7239	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		14939893	16306	0	None	-1	5	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		CHEMBL112244	16306	0	None	-1	5	Rat	8.4	pKi	=	8.4	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm00046a021
		44267730	23259	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	534	7	0	5	5.8	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12354	23259	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	534	7	0	5	5.8	COC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44383653	127629	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL355854	127629	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	347	3	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		44378982	64354	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	632	7	1	8	4.6	CC(=O)Nc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL166685	64354	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	632	7	1	8	4.6	CC(=O)Nc1ccccc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		16115799	90217	0	None	-4	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL219825	90217	0	None	-4	5	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	331	3	0	3	4.6	CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		156015254	185066	0	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4649420	185066	0	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4650938	185066	0	None	3	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	984	19	2	7	10.6	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		70681307	81231	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2021479	81231	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2027890	81231	0	None	2	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		10365639	127637	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	434	8	2	4	4.4	CCNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
		CHEMBL355874	127637	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	434	8	2	4	4.4	CCNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/S0960-894X(97)00109-1
		324	8706	15	None	-1	9	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
		6436265	8706	15	None	-1	9	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
		CHEMBL277642	8706	15	None	-1	9	Human	8.4	pKi	=	8.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/j.bmcl.2004.05.047
		11968014	19530	5	None	-3	9	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
		CHEMBL1187846	19530	5	None	-3	9	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedBinding affinity towards rat Muscarinic acetylcholine receptor M2 was determined	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm960374w
		154417	100035	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	100035	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		44627853	204460	0	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL571121	204460	0	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		324	8706	15	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		6436265	8706	15	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		CHEMBL277642	8706	15	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(02)00315-3
		44378599	64912	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c2c1OCO2	10.1016/s0960-894x(02)00024-0
		CHEMBL167839	64912	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c2c1OCO2	10.1016/s0960-894x(02)00024-0
		44344075	117266	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	608	7	0	7	4.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL324832	117266	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	608	7	0	7	4.9	COc1ccc(S(=O)(=O)c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6F)CC5)CC4)OCCO3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		16115950	143160	0	None	-1	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		CHEMBL373515	143160	0	None	-1	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	325	3	0	3	4.1	CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1	10.1021/jm061374r
		14210083	163491	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4070155	163491	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.9b02172
		174174	7311	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	7311	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	7311	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	7311	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	7311	49	None	-7	14	Human	8.3	pKi	=	8.3	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		10104167	8840	2	None	13	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
		6937	8840	2	None	13	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL3121473	8840	2	None	13	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/acs.jmedchem.7b01113
		44400180	75783	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	397	5	1	4	2.7	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
		CHEMBL192337	75783	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	397	5	1	4	2.7	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
		44296022	201703	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	498	6	1	4	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL54155	201703	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	498	6	1	4	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccnc5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44267734	17302	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	5	6.1	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11690	17302	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	530	8	0	5	6.1	CCOC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44406316	79497	0	None	-15	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	341	6	1	3	3.6	CCCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
		CHEMBL199821	79497	0	None	-15	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	341	6	1	3	3.6	CCCCCC(O)(C#CC1(OC)CN2CCC1CC2)c1ccccc1	10.1016/j.bmcl.2005.09.079
		44406689	148063	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cccnn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL383248	148063	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	349	3	1	5	1.8	COC1(C#CC(O)(c2ccccc2)c2cccnn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44299477	107493	0	None	95	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	191	2	0	4	0.6	c1cnc(O[C@@H]2CN3CCC2C3)cn1	10.1016/s0960-894x(99)00313-3
		CHEMBL292574	107493	0	None	95	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	191	2	0	4	0.6	c1cnc(O[C@@H]2CN3CCC2C3)cn1	10.1016/s0960-894x(99)00313-3
		18342968	174748	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	455	7	1	5	3.3	COc1ccc([S+]([O-])c2ccc(C(C(N)=O)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL431787	174748	0	None	6	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	455	7	1	5	3.3	COc1ccc([S+]([O-])c2ccc(C(C(N)=O)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		44437270	19100	0	None	13	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL1185211	19100	0	None	13	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL398043	19100	0	None	13	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	3	0.6	O=C1CCON1CC#CCN1CCCCC1	10.1016/j.bmc.2007.09.003
		2230	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		296	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		CHEMBL7303	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		DB04365	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		2230	7253	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		296	7253	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		CHEMBL7303	7253	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		DB04365	7253	60	None	-107	10	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		2230	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		296	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		CHEMBL7303	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		DB04365	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9705115
		2230	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		296	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		CHEMBL7303	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		DB04365	7253	60	None	-75	10	Human	7.4	pKi	=	7.4	Binding	The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cellsThe binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells	ChEMBL	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	10.1021/jm9904001
		118710666	127607	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323282	127607	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558210	127607	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		164627658	195388	0	None	20	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4875268	195388	0	None	20	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5029013	195388	0	None	20	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		10242813	43251	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	226	1	0	3	2.9	C1=C(c2nc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL144751	43251	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	226	1	0	3	2.9	C1=C(c2nc3ccccc3o2)C2CCN1CC2	10.1021/jm00003a011
		15169865	18035	0	None	5	3	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL1179079	18035	0	None	5	3	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL59085	18035	0	None	5	3	Rat	5.4	pKi	=	5.4	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		68764898	7459	2	None	-11	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
		9430	7459	2	None	-11	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
		CHEMBL3577945	7459	2	None	-11	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	491	7	1	5	5.3	CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@@H](C1=O)Nc1ncnc2c1cc(cc2)C(F)(F)F)N(C(C)C)C	10.1021/ml500505q
		167962	10841	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	10841	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	10841	4	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		72190450	99050	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426679	99050	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		109032820	189654	1	None	1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4791819	189654	1	None	1	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCCN(C(=O)CCN2CCCc3ccccc32)C1	10.1016/j.bmcl.2020.127632
		156015045	185044	0	None	17	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648218	185044	0	None	17	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650765	185044	0	None	17	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		11729182	12003	0	None	2	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	405	3	1	4	4.0	CCN(C)C(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL106259	12003	0	None	2	5	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	405	3	1	4	4.0	CCN(C)C(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		162353387	188010	0	None	2	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4761549	188010	0	None	2	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	274	2	1	3	2.2	O=C(CN1CCCc2ccc(O)cc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		162353380	189273	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	259	2	0	3	1.8	O=C(CN1CCCc2cnccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4786868	189273	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	259	2	0	3	1.8	O=C(CN1CCCc2cnccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		44437303	19098	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
		CHEMBL1185162	19098	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
		CHEMBL394329	19098	1	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	271	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc21	10.1016/j.bmc.2007.09.003
		44308899	210785	0	None	-37	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	330	5	2	3	2.7	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL69648	210785	0	None	-37	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	330	5	2	3	2.7	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1016/s0960-894x(03)00350-0
		2683	109665	25	None	-5	16	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	109665	25	None	-5	16	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	109665	25	None	-5	16	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		44431376	94092	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL233200	94092	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44593623	194659	0	None	-3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496503	194659	0	None	-3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539373	194659	0	None	-3	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		10428089	110224	0	None	-5	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	352	5	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc([N+](=O)[O-])cc1)C2	10.1021/jm00020a006
		CHEMBL3084899	110224	0	None	-5	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	352	5	0	4	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc([N+](=O)[O-])cc1)C2	10.1021/jm00020a006
		10330893	127899	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	215	2	0	2	2.8	COc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL357444	127899	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	215	2	0	2	2.8	COc1ccccc1C1=CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL69452	210753	0	None	2	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	331	6	1	5	2.7	CCO/C(O)=C1\CN2CC(CCC2COCc2ccccc2)C1=O	10.1021/jm020572p
		2551	7581	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		298	7581	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		488	7581	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL965	7581	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		DB00411	7581	23	None	-6	11	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		16125505	91553	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	1	2	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL223186	91553	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	1	2	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(CCc2ccccc2)CC1	10.1021/jm061159a
		6726	8063	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		7151	8063	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		749	8063	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		CHEMBL648	8063	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		DB01176	8063	51	None	-9	13	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
		9998508	86885	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21321	86885	0	None	2	5	Human	6.4	pKi	=	6.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	358	3	0	4	3.7	O=C(OC1CN2CCC1CC2)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		54816802	188051	2	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4762056	188051	2	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	258	2	0	2	2.5	O=C(CN1CCCc2ccccc21)N1CCCCC1	10.1016/j.bmcl.2020.127632
		118719929	122561	0	None	-3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	442	15	1	3	6.0	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354076	122561	0	None	-3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	442	15	1	3	6.0	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCO)CC1	10.1021/jm501173q
		156015051	185107	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4643329	185107	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651139	185107	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		156009660	185108	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4634475	185108	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651150	185108	0	None	3	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	360	5	0	3	3.0	C[N+](C)(C)C[C@@H]1CO[C@@H](c2ccc([S+]([O-])c3ccccc3)cc2)CO1	10.1021/acs.jmedchem.9b02100
		10982070	11938	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	2	0	6	3.7	COC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL105945	11938	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	2	0	6	3.7	COC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		137636308	162981	0	None	-13	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	329	7	0	3	2.8	CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4064222	162981	0	None	-13	8	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	329	7	0	3	2.8	CCCCN1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		44274317	90147	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL21937	90147	0	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	319	5	1	3	2.7	CN(C)CCNC(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		24894631	183543	3	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCCC1c1ccco1	10.1021/jm800145d
		CHEMBL460470	183543	3	None	-1	5	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCCC1c1ccco1	10.1021/jm800145d
		10404406	106977	0	None	19	2	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	330	3	1	4	2.2	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCOCC1	10.1021/jm970333f
		CHEMBL288285	106977	0	None	19	2	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	330	3	1	4	2.2	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCOCC1	10.1021/jm970333f
		10381417	75443	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		CHEMBL192061	75443	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	321	5	1	2	4.6	Cc1ccc(O)c(C(CCN2C[C@H]3C[C@H]3C2C)c2ccccc2)c1	10.1016/j.bmcl.2005.02.036
		14537189	169422	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
		CHEMBL416974	169422	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.	ChEMBL	412	9	0	5	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(OC(=O)N(C)C)cc1	10.1021/jm00127a020
		10066369	127036	0	None	8	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL352375	127036	0	None	8	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		44309135	103343	0	None	-54	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	7	2	3	3.7	NCCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL263040	103343	0	None	-54	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	394	7	2	3	3.7	NCCCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		10467755	127878	2	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2cc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL357200	127878	2	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	259	1	1	3	2.8	OC1(c2cc3ccccc3s2)CN2CCC1CC2	10.1021/jm00003a011
		137628855	167749	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4103087	167749	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115966	167749	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	1	1	1	2.0	C[N+](C)(C)C1CCc2cccc(O)c2C1	10.1021/acs.jmedchem.7b01113
		9998202	75941	0	None	-2	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192485	75941	0	None	-2	2	Rat	6.4	pKi	=	6.4	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		145961981	168310	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4128497	168310	0	None	-2	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	407	4	0	5	3.4	C[C@]1(C(=O)O[C@@H]2CN3CCC2CC3)COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		4715419	195520	34	None	4	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc(C2CCCN2)o1	10.1021/jm800145d
		CHEMBL505086	195520	34	None	4	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	1	2	2.0	Cc1ccc(C2CCCN2)o1	10.1021/jm800145d
		44392960	73075	0	None	9	2	Human	7.4	pKi	=	7.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL184843	73075	0	None	9	2	Human	7.4	pKi	=	7.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	345	2	0	3	4.6	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		15050959	210861	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	534	13	2	6	4.2	CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL70154	210861	0	None	1	2	Rat	7.4	pKi	=	7.4	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	534	13	2	6	4.2	CC(=O)NCCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		164627253	195382	0	None	28	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4876651	195382	0	None	28	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028989	195382	0	None	28	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		156015390	185021	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648229	185021	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650585	185021	0	None	-4	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		14964494	18729	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118292	18729	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		14964494	18729	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118292	18729	1	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		14956867	211607	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	228	1	0	4	0.6	CCN1C(=O)C2(CCN(C)CC2)OC1=S	10.1021/jm00068a005
		CHEMBL75380	211607	0	None	-4	2	Rat	5.4	pKi	=	5.4	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	228	1	0	4	0.6	CCN1C(=O)C2(CCN(C)CC2)OC1=S	10.1021/jm00068a005
		12739458	73325	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
		CHEMBL1824784	73325	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
		CHEMBL1852447	73325	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Inhibition of M2 muscarinic receptor by NIMH PDSPInhibition of M2 muscarinic receptor by NIMH PDSP	ChEMBL	227	2	0	1	3.5	c1ccc(CN2C3CC4CC(C3)CC2C4)cc1	10.1016/j.bmcl.2011.07.028
		15086396	20064	0	None	-29	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1191773	20064	0	None	-29	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL542915	20064	0	None	-29	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	357	8	0	7	2.4	CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1	10.1021/jm00114a005
		49783209	24381	0	None	-758	26	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	24381	0	None	-758	26	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		164614364	195274	0	None	2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4847458	195274	0	None	2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028248	195274	0	None	2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	733	15	9	10	-1.0	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCC(=O)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44448380	18687	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182644	18687	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		CHEMBL257804	18687	0	None	-1	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	436	7	1	1	5.0	C[N+]1(C)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1	10.1016/j.bmcl.2008.03.061
		156011518	185117	0	None	-6	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4637731	185117	0	None	-6	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651208	185117	0	None	-6	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	388	5	0	2	4.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)C(c2ccccc2)(c2ccccc2)O1	10.1021/acs.jmedchem.9b02100
		162353394	187549	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	245	2	0	3	1.5	O=C(CN1CCCc2cnccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4756237	187549	0	None	1	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	245	2	0	3	1.5	O=C(CN1CCCc2cnccc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		11828362	85695	0	None	-57	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112959	85695	0	None	-57	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	636	15	3	4	5.8	O=C(CCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		44431372	94090	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
		CHEMBL233198	94090	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
		21855	91021	42	None	-7	6	Human	7.4	pKi	=	7.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1016/s0960-894x(01)00186-x
		CHEMBL22108	91021	42	None	-7	6	Human	7.4	pKi	=	7.4	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1016/s0960-894x(01)00186-x
		11834199	65545	0	None	10	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCN(CC)CCC1=C(C(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL168704	65545	0	None	10	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCN(CC)CCC1=C(C(C)c2ccccn2)c2ccccc2C1	10.1021/jm020895l
		10651844	122267	0	None	-4	5	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
		CHEMBL335115	122267	0	None	-4	5	Rat	7.4	pKi	=	7.4	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	649	22	3	7	5.2	CN(CCCCCCCCN(C)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
		11695960	79170	0	None	-52	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	348	2	0	3	3.8	O=C(O[C@H]1CN2CCC1CC2)N1Cc2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL198669	79170	0	None	-52	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	348	2	0	3	3.8	O=C(O[C@H]1CN2CCC1CC2)N1Cc2ccccc2C1c1ccccc1	10.1021/jm050099q
		10024068	138128	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	402	6	0	3	3.9	CC(C)N(CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O)C(C)C	10.1016/S0960-894X(97)00143-1
		CHEMBL368792	138128	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	402	6	0	3	3.9	CC(C)N(CC#CCN1C(=O)CC(c2ccccc2)(c2ccccc2)C1=O)C(C)C	10.1016/S0960-894X(97)00143-1
		137630891	167908	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4085451	167908	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		CHEMBL4117201	167908	0	None	-1	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CCC([N+](C)(C)C)C2	10.1021/acs.jmedchem.7b01113
		10035281	107759	0	None	-1	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		CHEMBL294273	107759	0	None	-1	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	183	1	0	3	1.2	CC(=O)OC1CC2CCCC1N2C	10.1021/jm9904001
		574989	210849	2	None	-	1	Rat	5.4	pKi	=	5.4	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranesThe compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes	ChEMBL	495	5	1	6	4.1	CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL70082	210849	2	None	-	1	Rat	5.4	pKi	=	5.4	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranesThe compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes	ChEMBL	495	5	1	6	4.1	CN1CCN(CC(=O)N2c3cc(CO[Si](C)(C)C(C)(C)C)ccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		73353884	99097	0	None	-3	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
		CHEMBL2429890	99097	0	None	-3	8	Human	5.4	pKi	=	5.4	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	295	3	1	3	2.7	c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2	10.1016/j.bmc.2013.07.045
		44378600	63301	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	635	9	0	8	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1OC	10.1016/s0960-894x(02)00024-0
		CHEMBL163686	63301	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	635	9	0	8	5.2	COc1ccc(S(=O)(=O)c2ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc2)c(OC)c1OC	10.1016/s0960-894x(02)00024-0
		15730	77893	80	None	-2	10	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	77893	80	None	-2	10	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		164616776	195295	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL4852133	195295	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL5028394	195295	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	371	13	7	6	-1.5	CCCN[C@@H](CCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		3652	10869	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		57	10869	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		60809	10869	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		CHEMBL21536	10869	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		DB15357	10869	79	None	-18	18	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UR-AP060 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cell homogenate after 3 hrs by liquid scintillation counting assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.6b01892
		44392967	72381	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	4	0	3	5.0	CCN1C(CCC2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@H]23)CCC1(C)C	10.1016/j.bmcl.2004.05.047
		CHEMBL183331	72381	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	361	4	0	3	5.0	CCN1C(CCC2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@H]23)CCC1(C)C	10.1016/j.bmcl.2004.05.047
		164620290	195322	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4870729	195322	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028589	195322	0	None	5	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	916	22	9	12	0.6	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(C(=O)CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		164621861	195336	0	None	16	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4868124	195336	0	None	16	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028673	195336	0	None	16	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	704	17	8	9	1.5	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		14964511	18873	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1183954	18873	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL325473	18873	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		16086060	175722	0	None	-1148	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL438822	175722	0	None	-1148	5	Human	6.4	pKi	=	6.4	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		70693619	79918	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Negative allosteric modulation at M2 receptor by AS-MS analysisNegative allosteric modulation at M2 receptor by AS-MS analysis	ChEMBL	388	10	2	3	4.7	CC[C@@H](NCc1cccc(C(=O)NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmc.2011.11.071
		CHEMBL2011502	79918	0	None	-	1	Human	4.4	pKi	=	4.4	Binding	Negative allosteric modulation at M2 receptor by AS-MS analysisNegative allosteric modulation at M2 receptor by AS-MS analysis	ChEMBL	388	10	2	3	4.7	CC[C@@H](NCc1cccc(C(=O)NCCOc2ccccc2)c1)c1ccccc1	10.1016/j.bmc.2011.11.071
		483747	112186	3	None	-177	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding affinity to muscarinic receptor M2Inhibition of binding affinity to muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL311795	112186	3	None	-177	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding affinity to muscarinic receptor M2Inhibition of binding affinity to muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10139614	11803	0	None	-323	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	462	8	1	5	5.9	CCCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL105160	11803	0	None	-323	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	462	8	1	5	5.9	CCCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		441383	27105	57	None	-7	17	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	27105	57	None	-7	17	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		135398737	7745	93	None	-6	90	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		38	7745	93	None	-6	90	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		722	7745	93	None	-6	90	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		CHEMBL42	7745	93	None	-6	90	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		DB00363	7745	93	None	-6	90	Rat	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		155552923	183086	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4544820	183086	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4595245	183086	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	739	17	6	8	4.0	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		44379080	64939	0	None	1	3	Human	7.3	pKi	=	7.3	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	678	10	0	5	7.5	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)N(C(=O)c3ccc(F)cc3)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
		CHEMBL168149	64939	0	None	1	3	Human	7.3	pKi	=	7.3	Binding	Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)Tested in vitro for the binding affinity against muscarinic receptor subtype 2 (M2)	ChEMBL	678	10	0	5	7.5	CCN(CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)N(C(=O)c3ccc(F)cc3)c3ccccc32)CC1)C(=O)c1ccc(F)cc1	10.1016/S0960-894X(97)00109-1
		3072504	12584	7	None	-	1	Mouse	6.3	pKi	=	6.3	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107892	12584	7	None	-	1	Mouse	6.3	pKi	=	6.3	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		10429011	42902	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	240	1	0	1	3.6	C[N+]12C=C(c3cc4ccccc4o3)C(CC1)CC2	10.1021/jm00003a011
		CHEMBL144435	42902	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	240	1	0	1	3.6	C[N+]12C=C(c3cc4ccccc4o3)C(CC1)CC2	10.1021/jm00003a011
		9910802	127788	0	None	-141	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	4	4.2	O=C(NC1CCN(Cc2ccsc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL356505	127788	0	None	-141	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	434	6	2	4	4.2	O=C(NC1CCN(Cc2ccsc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		44312132	109079	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	406	5	0	4	4.4	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00438-8
		CHEMBL303443	109079	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	406	5	0	4	4.4	CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(c2ccccc2)CC1	10.1016/s0960-894x(00)00438-8
		10572657	47313	0	None	-45	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2cccnc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL148328	47313	0	None	-45	3	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2cccnc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		137639541	163482	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4070061	163482	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	206	3	0	3	1.7	CN1CCCC(OCc2cccnc2)C1	10.1021/acs.jmedchem.7b01113
		9906447	202356	2	None	-645	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL2031738	202356	2	None	-645	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		CHEMBL555146	202356	2	None	-645	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
		1273	8535	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		3450	8535	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		356	8535	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		6172	8535	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		67425	8535	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		CHEMBL360055	8535	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		DB00483	8535	16	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	10.1021/acs.jmedchem.6b01892
		2719	7704	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		5535	7704	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		607	7704	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		CHEMBL76	7704	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		DB00608	7704	74	None	-4	11	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	10.1038/s41586-020-2286-9
		46227487	20899	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198047	20899	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL593861	20899	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	216	2	0	2	1.7	CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C	10.1016/j.bmc.2009.10.027
		319	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		321	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		444031	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		784	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		CHEMBL1346	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		DB00496	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1021/jm010480k
		3042	8196	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		355	8196	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		868	8196	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		CHEMBL1123	8196	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		DB00804	8196	35	None	-12	15	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1021/jm00114a005
		16125585	91527	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.4	C[N+]1(CCOCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222976	91527	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.4	C[N+]1(CCOCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		73352330	98960	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2424680	98960	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		118710666	127607	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323282	127607	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558210	127607	0	None	-4	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	446	11	1	4	2.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		16125619	91498	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	427	5	2	3	4.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(O)c2)CC1	10.1021/jm061159a
		CHEMBL222804	91498	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	427	5	2	3	4.3	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccc(O)c2)CC1	10.1021/jm061159a
		14964506	120093	1	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL331556	120093	1	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		66561966	81478	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	193	2	0	1	3.2	C1CCC(CN2C3CCC2CC3)CC1	10.1016/j.bmcl.2012.04.077
		CHEMBL2030625	81478	0	None	-1	4	Human	5.3	pKi	=	5.3	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	193	2	0	1	3.2	C1CCC(CN2C3CCC2CC3)CC1	10.1016/j.bmcl.2012.04.077
		44437308	19099	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
		CHEMBL1185188	19099	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
		CHEMBL396845	19099	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	285	2	0	3	1.9	C[N+]1(CC#CCOC2=NOCC2)CCc2ccccc2C1	10.1016/j.bmc.2007.09.003
		73350931	99309	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	279	3	0	2	2.4	CN(Cc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432040	99309	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	279	3	0	2	2.4	CN(Cc1ccccc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		118719930	122562	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	470	17	1	3	6.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354077	122562	0	None	-5	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	470	17	1	3	6.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCCCO)CC1	10.1021/jm501173q
		10474335	201471	23	None	-165	10	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
		CHEMBL53325	201471	23	None	-165	10	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	370	6	0	3	4.8	COc1cccc2c1CCCC2CCCN1CCN(C2CCCCC2)CC1	10.1038/s41586-020-2286-9
		162658421	187880	0	None	3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4760150	187880	0	None	3	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	3	0	2	3.6	CC1CCCC(C)N1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		137644962	165272	0	None	-239	8	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	363	6	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4091058	165272	0	None	-239	8	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	363	6	0	3	3.2	O=C1CCc2ccccc2N1CCCN1CCN(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		44448457	18685	0	None	-4	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182638	18685	0	None	-4	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL257586	18685	0	None	-4	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	566	15	2	2	6.6	C[N+](C)(CCCC(O)(c1ccccc1)c1ccccc1)CC[N+](C)(C)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		24894515	183649	4	None	1	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@@H]1c1ccco1	10.1021/jm800145d
		CHEMBL461502	183649	4	None	1	5	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	151	1	0	2	2.0	CN1CCC[C@@H]1c1ccco1	10.1021/jm800145d
		44267709	23414	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	5	6.4	CC(C)OC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12419	23414	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	5	6.4	CC(C)OC(=O)CSc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccccc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		44431369	94758	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
		CHEMBL234253	94758	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	10.1016/j.bmcl.2006.11.058
		324	8706	15	None	-1	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
		6436265	8706	15	None	-1	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
		CHEMBL277642	8706	15	None	-1	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	10.1016/s0960-894x(99)00101-8
		3929516	114147	4	None	-5	4	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
		CHEMBL317757	114147	4	None	-5	4	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	343	4	0	2	4.7	CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2	10.1021/jm00020a006
		11610557	78806	0	None	-85	3	Rat	6.3	pKi	=	6.3	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
		CHEMBL197588	78806	0	None	-85	3	Rat	6.3	pKi	=	6.3	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1CC(O)c2ccccc2C1c1ccccc1	10.1021/jm050099q
		10551354	46531	0	None	-190	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	446	6	2	3	4.2	O=C(NC1CCN(Cc2cccc(F)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147611	46531	0	None	-190	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	446	6	2	3	4.2	O=C(NC1CCN(Cc2cccc(F)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		44304818	210085	0	None	-1	7	Rat	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64788	210085	0	None	-1	7	Rat	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
		44304818	210085	0	None	-1	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
		CHEMBL64788	210085	0	None	-1	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	169	1	1	3	0.7	COC(=O)C1CC2CCCC1N2	10.1021/jm9705115
		137629673	167938	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4094819	167938	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117396	167938	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	198	3	0	0	2.6	C[N+](C)(C)CCc1cccc(Cl)c1	10.1021/acs.jmedchem.7b01113
		456293	210837	1	None	-17	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL70010	210837	1	None	-17	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	603	6	0	7	5.2	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		44383489	135251	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	434	4	0	5	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C(=O)OC(C)(C)C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL366640	135251	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	434	4	0	5	4.3	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C(=O)OC(C)(C)C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		73346336	99320	0	None	1	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	5	0	2	3.0	CN(CCCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432054	99320	0	None	1	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	325	5	0	2	3.0	CN(CCCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		9308	24526	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
		CHEMBL1255785	24526	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
		CHEMBL12587	24526	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
		CHEMBL292911	24526	21	None	2	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1016/j.bmc.2007.12.036
		11809446	66453	0	None	1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL172234	66453	0	None	1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2ccccn2)c2ccccc2C1	10.1021/jm020895l
		44422692	18625	0	None	5	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1182296	18625	0	None	5	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL228144	18625	0	None	5	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	CC1COCC(C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		44446841	19110	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL1185281	19110	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		CHEMBL404557	19110	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmc.2009.10.027
		162657652	187764	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
		CHEMBL4758742	187764	0	None	-1	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	335	4	1	3	4.2	CCn1c2ccccc2c2ccc(NCC(=O)N3CCCCC3)cc21	10.1016/j.bmcl.2020.127632
		44431375	94091	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL233199	94091	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44431370	94759	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234254	94759	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		9308	24526	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
		CHEMBL1255785	24526	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
		CHEMBL12587	24526	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
		CHEMBL292911	24526	21	None	-2	7	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glandsBinding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm00088a029
		16086059	87550	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm301774u
		CHEMBL215180	87550	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm301774u
		16125618	175456	0	None	-19	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1ccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)cc1	10.1021/jm061159a
		CHEMBL436492	175456	0	None	-19	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1ccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)cc1	10.1021/jm061159a
		16086059	87550	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL215180	87550	0	None	-2187	7	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	662	9	3	5	3.9	O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		9821459	207222	11	None	-117	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	7	2	3	4.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
		CHEMBL59836	207222	11	None	-117	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	384	7	2	3	4.0	CC(C)=CCCN1CCC(NC(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1	10.1021/jm0003135
		15105207	175974	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	10	1	3	3.0	CCN(CC)CCOCCNC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL440686	175974	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	332	10	1	3	3.0	CCN(CC)CCOCCNC(=O)C1(c2ccccc2)CCCC1	10.1021/jm00041a006
		14537191	154767	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
		CHEMBL39342	154767	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	357	8	2	5	3.3	CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1	10.1021/jm00127a020
		474465	209850	2	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	525	6	0	5	5.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(Cc4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL63757	209850	2	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	525	6	0	5	5.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN(Cc3ccc(Cc4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00381-x
		44420791	91479	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	376	3	1	1	3.7	C[N+]1(C)C2CCC1CC(N1CC(c3ccccc3)(c3ccccc3)NC1=O)C2	10.1021/jm061160+
		CHEMBL222689	91479	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	376	3	1	1	3.7	C[N+]1(C)C2CCC1CC(N1CC(c3ccccc3)(c3ccccc3)NC1=O)C2	10.1021/jm061160+
		44325013	213973	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
		CHEMBL92569	213973	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantAntagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constant	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1021/acs.jmedchem.1c00790
		44295954	169674	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc5[nH]ccc5c4)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL417369	169674	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc5[nH]ccc5c4)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44295712	196288	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5c(F)cc(F)cc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51400	196288	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4cccc5c(F)cc(F)cc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44406521	80681	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL201933	80681	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccncc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		10199963	148093	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2cccc(F)c2)c2cccc(F)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL383389	148093	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	383	3	1	3	3.3	CO[C@]1(C#CC(O)(c2cccc(F)c2)c2cccc(F)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		10299489	210920	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	480	6	0	4	5.4	COc1ccc([S+]([O-])c2ccc(C(N3CCN(C4CCCCC4)CC3)C(F)(F)F)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL70464	210920	0	None	4	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	480	6	0	4	5.4	COc1ccc([S+]([O-])c2ccc(C(N3CCN(C4CCCCC4)CC3)C(F)(F)F)cc2)cc1	10.1016/s0960-894x(00)00438-8
		129989	7239	51	None	1	9	Rat	8.3	pKi	=	8.3	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
		8584	7239	51	None	1	9	Rat	8.3	pKi	=	8.3	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
		CHEMBL43383	7239	51	None	1	9	Rat	8.3	pKi	=	8.3	Binding	Affinity constant measured against M2 muscarinic receptor in rat heartAffinity constant measured against M2 muscarinic receptor in rat heart	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm00075a032
		129989	7239	51	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		8584	7239	51	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		CHEMBL43383	7239	51	None	-1	9	Human	8.3	pKi	=	8.3	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/acs.jmedchem.8b01967
		154417	100035	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL2449003	100035	60	None	-18	9	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	289	4	1	4	1.9	CN1[C@H]2CC[C@@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2	10.1021/jm500790x
		10049361	212900	0	None	-10	2	Human	8.3	pKi	=	8.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85892	212900	0	None	-10	2	Human	8.3	pKi	=	8.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccccc1)N(c1ccc(Br)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44325013	213973	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL92569	213973	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	604	8	0	8	4.2	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc(S(=O)(=O)c5ccc6c(c5)OCO6)cc4)CCCO3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		44431391	153199	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL392186	153199	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	10.1016/j.bmcl.2006.11.058
		118710662	127608	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	127608	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	127608	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		119357	7092	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
		3264	7092	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
		368	7092	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
		CHEMBL279453	7092	49	None	1	6	Human	8.3	pKi	=	8.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/0960-894X(96)00107-2
		118710662	127608	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	127608	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	127608	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		155548586	183376	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4537517	183376	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597611	183376	0	None	10	5	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	562	12	6	6	2.5	N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		70683405	81250	0	None	3	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2021477	81250	0	None	3	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		CHEMBL2027984	81250	0	None	3	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	406	4	1	4	3.7	CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21	10.1016/j.bmc.2008.06.025
		315401	96587	4	None	-4	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	343	8	1	4	3.5	CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377387	96587	4	None	-4	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	343	8	1	4	3.5	CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		44420795	18622	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL1182222	18622	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL223055	18622	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	426	6	1	1	4.4	C[N+]1(CCc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		14537188	143324	0	None	-1	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
		CHEMBL37372	143324	0	None	-1	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes	ChEMBL	341	8	1	4	3.6	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1	10.1021/jm00127a020
		10770914	31833	0	None	-19	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
		CHEMBL134692	31833	0	None	-19	5	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	691	25	3	7	6.4	CN(CCCCCCCCN(C)C(=O)CCCCCNCCCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN	10.1021/jm981038d
		42596929	83963	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042404	83963	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079021	83963	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	312	4	0	2	3.1	C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		688567	69808	4	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		CHEMBL1788199	69808	4	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	337	4	1	4	2.6	O=C(O[C@@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1021/jm00402a035
		425249	96572	8	None	10	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.6	CC(C)N(CCOC(=O)C(O)(c1ccccc1)c1ccccc1)C(C)C	10.1016/j.bmc.2013.01.072
		CHEMBL2377261	96572	8	None	10	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	355	8	1	4	3.6	CC(C)N(CCOC(=O)C(O)(c1ccccc1)c1ccccc1)C(C)C	10.1016/j.bmc.2013.01.072
		CHEMBL5277670	200722	0	None	-2	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	930	19	2	5	13.0	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		319	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		321	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		444031	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		784	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		CHEMBL1346	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		DB00496	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2005.09.079
		44406406	140315	0	None	-12	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	340	3	1	4	2.6	COC1(C#CC(O)(c2ccccn2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL370862	140315	0	None	-12	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	340	3	1	4	2.6	COC1(C#CC(O)(c2ccccn2)C2CCCC2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406520	142036	0	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL372566	142036	0	None	-3	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	CO[C@]1(C#C[C@](O)(c2ccccc2)c2cccnc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		44406395	147058	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2cccc(C)c2)c2cccc(C)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL380583	147058	0	None	-6	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2cccc(C)c2)c2cccc(C)c2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		24809738	18661	0	None	13	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
		CHEMBL1182466	18661	0	None	13	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
		CHEMBL239655	18661	0	None	13	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	209	3	0	3	1.1	Cc1cc(OCC#CC[N+](C)(C)C)no1	10.1016/j.bmc.2007.09.003
		15050958	210575	0	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	520	12	2	6	3.8	CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL68292	210575	0	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	520	12	2	6	3.8	CC(=O)NCCCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		3652	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		57	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		60809	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		CHEMBL21536	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		DB15357	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0301235
		118710668	127612	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	127612	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	127612	0	None	1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		44319043	212838	0	None	-17	2	Human	7.3	pKi	=	7.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85391	212838	0	None	-17	2	Human	7.3	pKi	=	7.3	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	410	5	0	3	5.7	O=C(c1cccs1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		3652	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		57	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		60809	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		CHEMBL21536	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		DB15357	10869	79	None	-18	18	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm0606995
		5387	101654	31	None	-19	6	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	10.1021/jm00111a032
		CHEMBL253978	101654	31	None	-19	6	Rat	7.3	pKi	=	7.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	10.1021/jm00111a032
		44313489	211409	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	400	9	1	3	4.6	CCN(CC)CCOCNC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		CHEMBL73501	211409	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	400	9	1	3	4.6	CCN(CC)CCOCNC(=O)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		2551	7581	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		298	7581	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		488	7581	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL965	7581	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		DB00411	7581	23	None	-3	11	Rat	5.3	pKi	=	5.3	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00075a007
		15196235	125971	2	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	181	1	0	2	1.5	C1COC(C2CN3CCC2CC3)C1	10.1021/jm00003a011
		CHEMBL343182	125971	2	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	181	1	0	2	1.5	C1COC(C2CN3CCC2CC3)C1	10.1021/jm00003a011
		15749864	107239	3	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	169	0	0	3	0.5	C1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		CHEMBL290715	107239	3	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	169	0	0	3	0.5	C1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		137629259	167783	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4092769	167783	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116203	167783	0	None	-2	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	204	2	0	1	1.8	COc1cccc(C#CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		44406387	79618	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2ccc(C)cc2)c2ccc(C)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200209	79618	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	375	3	1	3	3.7	CO[C@]1(C#CC(O)(c2ccc(C)cc2)c2ccc(C)cc2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		2247	7293	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	7293	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	7293	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	7293	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	7293	81	None	-32	42	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		71455896	90580	0	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	266	2	1	3	1.3	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccn1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205832	90580	0	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	266	2	1	3	1.3	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccn1	10.1016/j.bmcl.2012.08.046
		11819782	102661	0	None	10	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
		CHEMBL259131	102661	0	None	10	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	186	1	0	2	1.0	C[C@H]1OC[C@@H]([C@H]2CCC[N+]2(C)C)O1	10.1016/j.bmc.2007.12.036
		6604789	107824	5	None	-199	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		CHEMBL294649	107824	5	None	-199	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		10337773	108362	0	None	-125	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		CHEMBL298612	108362	0	None	-125	10	Human	4.3	pKi	=	4.3	Binding	Binding affinity against Muscarinic M2 receptorBinding affinity against Muscarinic M2 receptor	ChEMBL	311	3	1	4	1.6	Cn1cc(C(=O)C(=O)N[C@@H]2CN3CCC2CC3)c2ccccc21	10.1016/0960-894X(95)00308-G
		162670602	189716	0	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4792675	189716	0	None	1	2	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	248	2	0	2	1.8	O=C(CN1CCc2ccc(F)cc21)N1CCCC1	10.1016/j.bmcl.2020.127632
		4735	201894	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL361506	201894	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		CHEMBL55	201894	96	None	-9	10	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	nan
		11057	182928	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	182928	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	182928	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	182928	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		44344077	17222	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	616	7	0	6	6.2	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		CHEMBL116404	17222	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2Binding affinity towards Muscarinic acetylcholine receptor M2	ChEMBL	616	7	0	6	6.2	COc1ccc([S+]([O-])c2ccc(C3(C4CCN(C5CCN(C(=O)c6ccccc6C)CC5)CC4)O[C@H](C)[C@@H](C)O3)cc2)cc1	10.1016/s0960-894x(02)00742-4
		9974229	127064	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	335	4	0	4	3.1	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCOCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL352618	127064	0	None	4	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	335	4	0	4	3.1	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCOCC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		11808947	66227	0	None	4	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	CC(C1=C(CN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL171216	66227	0	None	4	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	CC(C1=C(CN(C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		10203251	11996	0	None	-257	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	5	0	6	4.8	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(OC)cc2CCN1C3	10.1021/jm011116o
		CHEMBL106224	11996	0	None	-257	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	434	5	0	6	4.8	CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(OC)cc2CCN1C3	10.1021/jm011116o
		11004046	12226	0	None	-33	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	3	0	6	4.1	CCOC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL107444	12226	0	None	-33	5	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	406	3	0	6	4.1	CCOC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		15678856	110558	0	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	394	5	2	6	1.3	NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL308893	110558	0	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	394	5	2	6	1.3	NCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		3652	53018	70	None	-2	9	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
		CHEMBL1535	53018	70	None	-2	9	Human	5.3	pKi	=	5.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	ChEMBL	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	10.1038/s41586-020-2286-9
		162353388	187758	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
		CHEMBL4758633	187758	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCC[C@H]1CO	10.1016/j.bmcl.2020.127632
		162353384	187869	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
		CHEMBL4760037	187869	0	None	2	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	4	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC1CO	10.1016/j.bmcl.2020.127632
		11515739	85107	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL2092736	85107	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL2109804	85107	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		16124705	91404	0	None	-77	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	451	5	1	2	5.8	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		CHEMBL222207	91404	0	None	-77	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	451	5	1	2	5.8	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		2812	11551	101	None	-33	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	11551	101	None	-33	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		107867	9748	55	None	2	11	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
		309	9748	55	None	2	11	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
		CHEMBL17045	9748	55	None	2	11	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1016/0960-894X(96)00107-2
		137645406	164681	0	None	-6	13	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
		CHEMBL4084262	164681	0	None	-6	13	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
		164628906	195395	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4877107	195395	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5029079	195395	0	None	10	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	888	20	9	12	-0.2	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(C(=O)CCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		44382974	66287	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL171520	66287	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		16124708	144114	0	None	-28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	0	2	5.0	CN1C(=O)N(C2CCN(Cc3ccccc3)CC2)CC1(c1ccccc1)c1ccccc1	10.1021/jm061159a
		CHEMBL375277	144114	0	None	-28	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	5	0	2	5.0	CN1C(=O)N(C2CCN(Cc3ccccc3)CC2)CC1(c1ccccc1)c1ccccc1	10.1021/jm061159a
		14964513	18191	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1180268	18191	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL119508	18191	0	None	-	1	Rat	4.3	pKi	=	4.3	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		2200	9905	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		328	9905	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		4848	9905	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		CHEMBL9967	9905	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		DB00670	9905	46	None	-35	13	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm301774u
		44450620	102606	0	None	3	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL258905	102606	0	None	3	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		44422697	18624	0	None	4	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1182277	18624	0	None	4	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL227429	18624	0	None	4	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		12259685	208327	11	None	-6	4	Rat	6.3	pKi	=	6.3	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	285	2	1	2	3.9	CC(C)=CCN1CC[C@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm00039a008
		CHEMBL60542	208327	11	None	-6	4	Rat	6.3	pKi	=	6.3	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	285	2	1	2	3.9	CC(C)=CCN1CC[C@]2(C)c3cc(O)ccc3C[C@H]1[C@H]2C	10.1021/jm00039a008
		44378769	126820	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1cc2c(cc1S(=O)(=O)c1ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc1)OCO2	10.1016/s0960-894x(02)00024-0
		CHEMBL350404	126820	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	619	7	0	8	4.9	COc1cc2c(cc1S(=O)(=O)c1ccc([C@H](C)N3CCN(C4CCN(C(=O)c5ccccc5C)CC4)C[C@H]3C)cc1)OCO2	10.1016/s0960-894x(02)00024-0
		156009698	185115	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4634575	185115	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		CHEMBL4651200	185115	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assay	ChEMBL	872	16	2	5	11.0	C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.9b02172
		9846311	210790	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1016/s0960-894x(03)00350-0
		CHEMBL69678	210790	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1016/s0960-894x(03)00350-0
		9846311	210790	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
		CHEMBL69678	210790	12	None	-346	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1	10.1021/jm0003135
		44309107	108952	0	None	-8	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1ccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)cc1	10.1016/s0960-894x(03)00350-0
		CHEMBL302720	108952	0	None	-8	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	360	5	3	3	3.4	NCc1ccc(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)cc1	10.1016/s0960-894x(03)00350-0
		10176401	161747	19	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	CC1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		CHEMBL40121	161747	19	None	-1	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	183	0	0	3	0.8	CC1OC2(CCN(C)CC2)CC1=O	10.1016/0960-894X(95)00301-9
		10344314	100888	0	None	-12	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	462	8	2	5	3.1	COC(=O)c1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
		CHEMBL249204	100888	0	None	-12	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	462	8	2	5	3.1	COC(=O)c1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1	10.1016/j.bmcl.2007.06.081
		11498	9793	41	None	-67	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
		4995951	9793	41	None	-67	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
		CHEMBL59898	9793	41	None	-67	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	392	3	1	5	4.1	CCOC(=O)c1c(C)[nH]c2c1c1CN3CCc4c(C3Oc1cc2)ccc(c4)OC	10.1021/jm011116o
		11011332	127580	1	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL355560	127580	1	None	-1	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		156010362	185111	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4633296	185111	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651171	185111	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		11112362	11731	0	None	-4	5	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	410	3	1	3	5.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(Cc5ccccc5)c34)OC21	10.1021/jm011116o
		CHEMBL104804	11731	0	None	-4	5	Human	5.3	pKi	=	5.3	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	410	3	1	3	5.5	COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(Cc5ccccc5)c34)OC21	10.1021/jm011116o
		9998829	110196	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	363	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(C)(C)C)cc1)C2	10.1021/jm00020a006
		CHEMBL3084866	110196	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	363	4	0	2	5.7	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C(C)(C)C)cc1)C2	10.1021/jm00020a006
		118710660	127609	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323279	127609	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558230	127609	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	432	11	1	3	3.7	C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		46682613	187935	1	None	2	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4760823	187935	1	None	2	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	4	1	2	3.3	O=C(CCN1CCCc2ccccc21)NC1CCCCC1	10.1016/j.bmcl.2020.127632
		156014205	185071	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4635385	185071	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650957	185071	0	None	-5	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		71575652	92973	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	381	5	0	4	3.6	CN1CCC(c2ccccc2F)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
		CHEMBL2312352	92973	0	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	381	5	0	4	3.6	CN1CCC(c2ccccc2F)=C(C(=O)OCCc2ccc3c(c2)CCO3)C1	10.1021/jm301774u
		44308831	211174	0	None	-44	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.2	CNCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL71933	211174	0	None	-44	3	Human	5.3	pKi	=	5.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	380	6	2	3	3.2	CNCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44593627	200078	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524071	200078	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL541671	200078	0	None	-3	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		44448417	18681	0	None	-8	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182629	18681	0	None	-8	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL256923	18681	0	None	-8	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	550	16	2	4	6.7	CN(CCCN(C)CCCC(O)(c1ccccc1)c1ccccc1)CCCC(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		57664406	9177	50	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		6938	9177	50	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		CHEMBL4089376	9177	50	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assayDisplacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.6b01892
		44308832	210592	0	None	-45	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	364	4	2	3	2.8	NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL68384	210592	0	None	-45	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	364	4	2	3	2.8	NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		14964495	19385	1	None	4	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118700	19385	1	None	4	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	C[C@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		2733619	18683	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		6508725	18683	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		CHEMBL1182634	18683	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		CHEMBL257431	18683	8	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	451	16	0	1	6.8	CCCCN(CCCC)c1ccc(/C=C/c2cc[n+](CCC[N+](CC)(CC)CC)cc2)cc1	10.1016/j.bmcl.2007.11.022
		10475156	128301	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	258	1	1	2	2.5	C[N+]12CCC(CC1)C(O)(c1cc3ccccc3o1)C2	10.1021/jm00003a011
		CHEMBL358493	128301	0	None	-1	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	258	1	1	2	2.5	C[N+]12CCC(CC1)C(O)(c1cc3ccccc3o1)C2	10.1021/jm00003a011
		15086393	20063	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL1191772	20063	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
		CHEMBL542914	20063	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	ChEMBL	358	8	0	4	4.0	CCN(CC)CCOC(=O)C1(c2ccc(N3CCCC3)cc2)CCCC1	10.1021/jm00114a005
		71457691	90574	0	None	-1	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccccc1CN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205823	90574	0	None	-1	10	Human	6.3	pKi	=	6.3	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	295	3	1	3	2.0	COc1ccccc1CN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		16125640	91517	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	486	10	1	3	4.3	COCC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222917	91517	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	486	10	1	3	4.3	COCC[N+]1(CCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		205895	18640	2	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		CHEMBL118240	18640	2	None	1	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		10457079	16802	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL115078	16802	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		137645938	164362	0	None	-407	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	342	8	0	2	4.6	CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4080675	164362	0	None	-407	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	342	8	0	2	4.6	CCCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1	10.1021/acs.jmedchem.8b00265
		44593617	194210	0	None	-2	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493795	194210	0	None	-2	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	341	3	0	3	3.1	CN1CCC[C@H]1[C@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		44443733	161563	0	None	-45	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL400167	161563	0	None	-45	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	382	7	2	3	3.5	CC(C)=CCCN1C[C@H]2[C@H](NC(=O)[C@](O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		202119	18807	3	None	1	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL1183388	18807	3	None	1	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL294470	18807	3	None	1	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.	ChEMBL	172	2	0	2	0.4	C[C@H]1O[C@@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		71461700	86369	0	None	7	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@@H]1CCCN1	10.1021/jm00087a008
		CHEMBL2114425	86369	0	None	7	2	Rat	5.3	pKi	=	5.3	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	206	2	1	2	0.8	O=C1CCCN1CC#CC[C@@H]1CCCN1	10.1021/jm00087a008
		15678860	109160	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	450	9	2	6	2.8	NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL303876	109160	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	450	9	2	6	2.8	NCCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		44593627	200078	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524071	200078	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL541671	200078	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		145961161	168385	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		CHEMBL4129580	168385	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		44382880	127538	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	362	4	1	4	3.5	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C(C)CN1	10.1016/s0960-894x(99)00101-8
		CHEMBL355193	127538	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	362	4	1	4	3.5	CC1CN(CCC[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)O[C@@H](C)[C@@H]32)C(C)CN1	10.1016/s0960-894x(99)00101-8
		137629744	167954	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL4071109	167954	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		CHEMBL4117602	167954	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1ccccc1CC[N+](C)(C)C	10.1021/acs.jmedchem.7b01113
		44392984	19029	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL1184654	19029	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL362864	19029	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	358	2	0	2	4.6	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)[N+]3(C)C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		483747	112186	3	None	-177	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL311795	112186	3	None	-177	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	503	4	0	5	4.9	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		10066369	127036	0	None	8	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL352375	127036	0	None	8	6	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	348	7	0	2	5.7	CC(C1=C(CCN(C(C)C)C(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		133640439	188152	1	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4763304	188152	1	None	1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	1.9	O=C(O)C1CCCN1C(=O)CCN1CCCc2ccccc21	10.1016/j.bmcl.2020.127632
		611107	210723	1	None	-1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	451	7	3	7	0.4	NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL69287	210723	1	None	-1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	451	7	3	7	0.4	NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		71458134	86463	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL2115362	86463	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	0	2	1.1	CN1CCC[C@@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		11120347	127507	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
		CHEMBL354841	127507	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	5	0	2	4.5	Cc1ccc2c(c1)CC(CCN(C)C)=C2C(C)c1ccccn1	10.1021/jm020895l
		15678858	108926	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	7	2	6	2.1	NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL302544	108926	0	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	422	7	2	6	2.1	NCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		59291578	119562	0	None	-6	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3298594	119562	0	None	-6	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		CHEMBL3305763	119562	0	None	-6	3	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	ChEMBL	313	3	1	5	3.0	O=C(Nc1ncoc1-c1ccccc1)O[C@H]1CN2CCC1CC2	10.1016/j.bmc.2014.04.031
		1726	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1726	9275	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		1993	9275	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		7438	9275	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		CHEMBL978	9275	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		DB06709	9275	13	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	10.1021/jm9705115
		44383305	66127	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	578	8	0	8	4.2	O=C(COc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL170739	66127	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	578	8	0	8	4.2	O=C(COc1ccccc1)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		4098	39279	30	None	-15	11	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1255739	39279	30	None	-15	11	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		CHEMBL1411979	39279	30	None	-15	11	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
		44383373	66164	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	348	4	0	4	3.0	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL170922	66164	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	348	4	0	4	3.0	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCN(C)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		44295953	195815	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4c[nH]c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL50927	195815	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	486	6	2	3	4.9	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4c[nH]c5ccccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		44382739	127174	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	516	6	0	8	3.7	CCOC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL353465	127174	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	516	6	0	8	3.7	CCOC(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		9905731	175287	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL435353	175287	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		119357	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
		3264	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
		368	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
		CHEMBL279453	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1016/s0960-894x(01)00186-x
		44428745	98952	0	None	3	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	635	23	2	6	7.9	COc1ccccc1CNCCCCCCN1CCC(CCC2CCN(CCCCCCNCc3ccccc3OC)CC2)CC1	10.1016/j.bmc.2007.01.022
		CHEMBL242345	98952	0	None	3	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cellsDisplacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells	ChEMBL	635	23	2	6	7.9	COc1ccccc1CNCCCCCCN1CCC(CCC2CCN(CCCCCCNCc3ccccc3OC)CC2)CC1	10.1016/j.bmc.2007.01.022
		119357	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
		3264	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
		368	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
		CHEMBL279453	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assayDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in stable CHO-K1 cells by radioligand binding assay	ChEMBL	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	10.1021/acs.jmedchem.8b01967
		46188794	185098	0	None	-19	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4645580	185098	0	None	-19	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4651099	185098	0	None	-19	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		44267747	16833	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	4	7.7	CC(C)Oc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
		CHEMBL11527	16833	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	544	8	0	4	7.7	CC(C)Oc1ccc2c(C(=O)N3CCC(N4CCC(Cc5ccc(SC(C)C)cc5)CC4)CC3)cccc2c1	10.1016/s0960-894x(02)00096-3
		118710670	127611	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	127611	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	127611	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		11531644	183192	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
		CHEMBL4560341	183192	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
		CHEMBL4596085	183192	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of M2 receptor (unknown origin)Inhibition of M2 receptor (unknown origin)	ChEMBL	330	5	1	2	3.3	C[N+]12CCC(CC1)C(OCC(O)(c1ccccc1)C1CCCC1)C2	10.1021/acs.jmedchem.8b01520
		44431382	94796	0	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234438	94796	0	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		199230	169914	21	None	37	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		CHEMBL41779	169914	21	None	37	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		10086238	85683	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	301	7	0	5	3.5	CN1CCC=C(c2nsnc2SCCCCCF)C1	10.1021/jm00001a002
		CHEMBL2112940	85683	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranesIn vitro binding affinity towards Muscarinic acetylcholine receptor M2 was determined by measuring its ability to displace [3H]-AF-DX 384 from rat heart membranes	ChEMBL	301	7	0	5	3.5	CN1CCC=C(c2nsnc2SCCCCCF)C1	10.1021/jm00001a002
		66875589	110167	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		CHEMBL3084662	110167	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membraneDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cell membrane	ChEMBL	321	4	1	2	4.2	CN1[C@H]2CC[C@@H]1C[C@H](CC(O)(c1ccccc1)c1ccccc1)C2	10.1016/j.bmcl.2009.07.006
		10155225	102615	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	3	3.6	COC1(C#CC(C#N)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		CHEMBL258959	102615	0	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methylscopolamine from human recombinant muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	3	3.6	COC1(C#CC(C#N)(c2ccccc2)c2ccccc2)CN2CCC1CC2	10.1016/j.bmcl.2008.03.024
		14210083	163491	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		CHEMBL4070155	163491	1	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cellsDisplacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells	ChEMBL	478	9	2	5	4.5	CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/acs.jmedchem.6b01892
		118710670	127611	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	127611	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	127611	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		10163651	170012	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL418446	170012	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	493	5	1	4	5.3	CC(=C1CCN(C2CCN(C(=O)c3cccc(C)c3N)CC2)CC1)c1ccc([S+]([O-])C(C)C)cc1	10.1021/jm0255163
		CHEMBL5273907	200564	0	None	-7	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	945	20	2	5	13.3	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		44627740	205537	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL583051	205537	0	None	-5	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		10497101	77244	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	336	4	1	3	3.6	O=C(NC(c1ccccc1)c1ccccc1)OC1CN2CCC1CC2	10.1021/jm050099q
		CHEMBL194628	77244	0	None	-4	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	336	4	1	3	3.6	O=C(NC(c1ccccc1)c1ccccc1)OC1CN2CCC1CC2	10.1021/jm050099q
		13773336	86458	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2115342	86458	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		9894136	173015	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	9	0	8	3.7	CCCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		CHEMBL426761	173015	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligandBinding affinity towards Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand	ChEMBL	564	9	0	8	3.7	CCCCS(=O)(=O)N1CCC(N2CCC(Oc3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)CC2)CC1	10.1016/s0960-894x(01)00100-7
		939077	201847	2	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		CHEMBL549577	201847	2	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	335	2	0	4	3.6	O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		2705	10614	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		360	10614	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		443879	10614	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		CHEMBL1382	10614	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		DB01036	10614	64	None	-1	10	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1016/j.bmcl.2005.02.036
		118710668	127612	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	127612	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	127612	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		2028	9753	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		359	9753	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		4634	9753	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		CHEMBL1231	9753	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		DB01062	9753	80	None	-5	11	Rat	8.2	pKi	=	8.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2005.02.036
		302	9751	25	None	-4	8	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		4630	9751	25	None	-4	8	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL7634	9751	25	None	-4	8	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00075a007
		303	9752	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		4629	9752	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		8595	9752	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL44674	9752	17	None	1	6	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		44627854	204488	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL571341	204488	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	339	4	1	3	4.9	CN1CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		156015971	185061	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4648444	185061	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650880	185061	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	318	4	0	2	3.6	C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1	10.1021/acs.jmedchem.9b02100
		9991979	125936	1	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	3	3.4	C1=C(c2nc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL342958	125936	1	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	242	1	0	3	3.4	C1=C(c2nc3ccccc3s2)C2CCN1CC2	10.1021/jm00003a011
		14964507	121132	1	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		CHEMBL333107	121132	1	None	-5	2	Rat	5.2	pKi	=	5.2	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@H]1CC(=O)N(CC#CCN2CCCC2)C1	10.1021/jm00075a007
		75356563	163736	23	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
		CHEMBL4072787	163736	23	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	184	3	1	4	1.0	c1csc(COC2CCNC2)n1	10.1021/acs.jmedchem.7b01113
		118719926	122558	0	None	-138	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	358	9	1	3	3.6	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1	10.1021/jm501173q
		CHEMBL3354073	122558	0	None	-138	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	358	9	1	3	3.6	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCO)CC1	10.1021/jm501173q
		11001809	65855	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL169594	65855	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	322	6	0	4	2.7	CN(C)CCOC(=O)C1=C(Cc2cccnc2)c2ccccc2C1	10.1021/jm020895l
		46227461	20908	0	None	-1	5	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198077	20908	0	None	-1	5	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL594803	20908	0	None	-1	5	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		631644	210856	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	551	8	3	8	2.0	CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL70133	210856	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	551	8	3	8	2.0	CC(C)(C)OC(=O)NCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		118710664	127610	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	127610	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	127610	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		60138186	127614	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	127614	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	127614	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	127614	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		145960827	168159	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		CHEMBL4126290	168159	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	379	5	0	4	3.5	c1ccc(C2(c3ccccc3)COC[C@@H](CO[C@@H]3CN4CCC3CC4)O2)cc1	10.1016/j.ejmech.2017.06.004
		2200	9905	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		328	9905	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		4848	9905	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		CHEMBL9967	9905	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		DB00670	9905	46	None	-31	13	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00111a032
		1353	8692	93	None	-338	85	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		3559	8692	93	None	-338	85	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		86	8692	93	None	-338	85	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		CHEMBL54	8692	93	None	-338	85	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		DB00502	8692	93	None	-338	85	Rat	5.2	pKi	=	5.2	Binding	Binding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured against muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		502259	123576	1	None	-61	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	571	4	0	5	5.9	Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL337820	123576	1	None	-61	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	571	4	0	5	5.9	Cc1nc(C(F)(F)F)nc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(C(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		909982	208873	10	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
		CHEMBL608828	208873	10	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	169	1	0	3	0.6	CC(=O)O[C@@H]1CN2CCC1CC2	10.1016/j.bmc.2007.12.036
		162353390	187728	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4758316	187728	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	302	4	1	3	2.1	O=C(CCN1CCCc2ccccc21)N1CCCC(CO)C1	10.1016/j.bmcl.2020.127632
		109035056	188102	1	None	7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
		CHEMBL4762755	188102	1	None	7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	331	4	1	3	4.0	O=C(CCN1CCCc2ccccc21)Nc1cccc2cccnc12	10.1016/j.bmcl.2020.127632
		164609373	195243	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL4846035	195243	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL5027958	195243	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	456	16	8	7	-1.6	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		162353378	189690	0	None	3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
		CHEMBL4792360	189690	0	None	3	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	288	3	1	3	1.8	O=C(CCN1CCCc2ccccc21)N1CCCC(O)C1	10.1016/j.bmcl.2020.127632
		44446841	19110	0	None	2	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1185281	19110	0	None	2	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL404557	19110	0	None	2	4	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		11819882	24215	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2cccs2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL125764	24215	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	191	1	0	2	2.8	C1=C(c2cccs2)C2CCN1CC2	10.1021/jm00003a011
		16124769	91555	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	0	2	5.3	O=C1N(C2CCN(Cc3ccccc3)CC2)CC(c2ccccc2)N1Cc1ccccc1	10.1021/jm061159a
		CHEMBL223188	91555	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	425	6	0	2	5.3	O=C1N(C2CCN(Cc3ccccc3)CC2)CC(c2ccccc2)N1Cc1ccccc1	10.1021/jm061159a
		319	8106	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		321	8106	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		444031	8106	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		784	8106	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		CHEMBL1346	8106	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		DB00496	8106	44	None	-18	9	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1016/j.bmcl.2007.06.081
		10125445	82803	0	None	-25	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
		CHEMBL205654	82803	0	None	-25	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	ChEMBL	286	4	1	4	3.6	Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1	10.1016/j.bmcl.2006.01.006
		164615651	195290	0	None	41	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4852079	195290	0	None	41	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028329	195290	0	None	41	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		16094793	90097	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsc(OCCCOCCCOCCCOc2nsnc2-c2cccnc2)n1	10.1021/jm0606995
		CHEMBL219118	90097	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	467	16	0	12	3.1	COc1nsc(OCCCOCCCOCCCOc2nsnc2-c2cccnc2)n1	10.1021/jm0606995
		9799291	166899	0	None	-169	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	2	3	2.9	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL410890	166899	0	None	-169	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	2	3	2.9	NCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		14964497	21063	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119985	21063	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		3013846	195018	2	None	-4	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
		CHEMBL499519	195018	2	None	-4	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsBinding affinity to human muscarinic M2 receptor expressed in insect Sf9 cells	ChEMBL	757	23	5	11	5.9	CCCCCCCCCCCC(OC(=O)C(CCCCN(O)C(C)=O)NC(=O)c1coc(-c2ccccc2O)n1)C(C)C(=O)NC1CCCCN(O)C1=O	10.1021/np050091j
		137631178	167983	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4081662	167983	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117768	167983	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	208	5	0	1	2.3	COc1cccc(CCC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		44443728	100807	0	None	-25	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.9	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		CHEMBL248809	100807	0	None	-25	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.9	CC(c1ccccc1)N1C[C@H]2[C@H](NC(=O)C(O)(c3ccccc3)C3CCCC3)[C@H]2C1	10.1016/j.bmcl.2007.06.081
		44318969	212859	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	5.0	O=C(c1ccccc1)N(Cc1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85568	212859	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	384	6	0	2	5.0	O=C(c1ccccc1)N(Cc1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44319016	212916	0	None	-25	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccc(Cl)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL86012	212916	0	None	-25	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccc(Cl)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		44319017	213088	0	None	-19	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccc(Br)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL87132	213088	0	None	-19	2	Human	6.2	pKi	=	6.2	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	448	5	0	2	5.8	O=C(c1ccc(Br)cc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		10418420	77048	0	None	-47	4	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	955	27	0	10	10.9	CN(CCCCCCCCN(C)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00113-8
		CHEMBL194216	77048	0	None	-47	4	Rat	6.2	pKi	=	6.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	955	27	0	10	10.9	CN(CCCCCCCCN(C)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2)CCCCCCN1CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2	10.1016/0960-894X(95)00113-8
		11169365	119289	0	None	-99	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
		CHEMBL3298986	119289	0	None	-99	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)	ChEMBL	502	11	6	7	4.0	CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1	10.1016/j.bmcl.2014.04.095
		137630084	167824	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4070055	167824	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116507	167824	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	192	1	0	1	1.8	COc1cccc2c1C[N+](C)(C)CC2	10.1021/acs.jmedchem.7b01113
		57326140	83954	0	None	2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL2042400	83954	0	None	2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		CHEMBL2078962	83954	0	None	2	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	188	3	0	2	0.9	CC[C@H]1COC[C@@H](C[N+](C)(C)C)O1	10.1021/jm2013216
		44406451	79717	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	385	2	1	3	3.8	CO[C@]1(C#CC(O)C2c3ccccc3C=Cc3ccccc32)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200566	79717	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	385	2	1	3	3.8	CO[C@]1(C#CC(O)C2c3ccccc3C=Cc3ccccc32)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		542182	108938	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	465	8	3	7	0.8	NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL302604	108938	1	None	1	3	Rat	5.2	pKi	=	5.2	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	465	8	3	7	0.8	NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		71460014	86461	0	None	4	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@H]1CCCCN1	10.1021/jm00087a008
		CHEMBL2115360	86461	0	None	4	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	220	2	1	2	1.1	O=C1CCCN1CC#CC[C@H]1CCCCN1	10.1021/jm00087a008
		44400887	77773	0	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	360	5	2	3	2.0	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
		CHEMBL195169	77773	0	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	360	5	2	3	2.0	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2005.02.036
		60138186	127614	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	127614	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	127614	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	127614	0	None	23	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		44627741	204461	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	317	4	0	2	5.2	CN1CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		CHEMBL571123	204461	0	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	317	4	0	2	5.2	CN1CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1	10.1021/jm901048j
		44593619	194239	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL493980	194239	0	None	-6	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		44308746	210630	0	None	-138	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	3	2	3	2.6	CC1(N)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL68609	210630	0	None	-138	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	3	2	3	2.6	CC1(N)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		10572658	128758	0	None	-33	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccncc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL359197	128758	0	None	-33	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	393	6	2	4	3.2	O=C(NC1CCN(Cc2ccncc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		167962	10841	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	10841	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	10841	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		162675053	190037	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
		CHEMBL4796491	190037	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	300	5	1	3	3.2	O=C(CCN1CCCc2ccccc21)NCc1cccs1	10.1016/j.bmcl.2020.127632
		44578707	188920	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@@H]21	10.1016/j.bmc.2008.06.025
		CHEMBL478227	188920	0	None	2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	405	2	1	5	2.9	CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)[C@@H]2CCCC[C@@H]21	10.1016/j.bmc.2008.06.025
		57664406	9177	50	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		6938	9177	50	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089376	9177	50	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometryDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells by FACSCalibur flow cytometry	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		164618644	195310	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL4872142	195310	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		CHEMBL5028508	195310	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	385	14	7	6	-1.1	CCCN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(C)=O	10.1016/j.ejmech.2021.113159
		57326144	83966	0	None	1	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042402	83966	0	None	1	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2079061	83966	0	None	1	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccccc2)O1	10.1021/jm2013216
		10457079	16802	0	None	-4	2	Human	4.2	pKi	=	4.2	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL115078	16802	0	None	-4	2	Human	4.2	pKi	=	4.2	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	462	19	3	5	4.0	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		162353389	188303	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	2	3	3.3	O=C(CCN1CCCc2ccccc21)Nc1ccc(O)cc1F	10.1016/j.bmcl.2020.127632
		CHEMBL4765133	188303	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	314	4	2	3	3.3	O=C(CCN1CCCc2ccccc21)Nc1ccc(O)cc1F	10.1016/j.bmcl.2020.127632
		44443735	101158	0	None	-52	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)[C@](O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL250834	101158	0	None	-52	2	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	448	7	2	5	3.1	O=C(N[C@H]1[C@@H]2CN(CCc3ccc4c(c3)OCO4)C[C@@H]21)[C@](O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		9998202	75941	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192485	75941	0	None	-2	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	353	5	1	4	2.6	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2005.02.036
		44420821	91063	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	2	5.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CC2CCC(C1)N2Cc1ccccc1	10.1021/jm061159a
		CHEMBL221400	91063	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	437	5	1	2	5.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CC2CCC(C1)N2Cc1ccccc1	10.1021/jm061159a
		44383352	66466	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCC(N4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		CHEMBL172272	66466	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligandBinding affinity towards human muscarinic M2 receptor in CHO-KI cells using [3H]- QNB as radioligand	ChEMBL	416	5	0	4	4.7	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CCCN3CCC(N4CCCCC4)CC3)[C@@H]12	10.1016/s0960-894x(99)00101-8
		10096017	110222	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	463	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Br)cc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
		CHEMBL3084897	110222	0	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	463	4	0	2	5.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccc(Br)cc1)c1ccc(Br)cc1)C2	10.1021/jm00020a006
		118719920	122551	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	509	10	0	7	4.5	CN1CCC=C(c2nsnc2OCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354066	122551	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	509	10	0	7	4.5	CN1CCC=C(c2nsnc2OCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		44593620	194715	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496915	194715	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	347	3	0	3	3.7	CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		302	9751	25	None	-34	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		4630	9751	25	None	-34	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		CHEMBL7634	9751	25	None	-34	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm9904001
		2551	7581	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		298	7581	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		488	7581	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		CHEMBL965	7581	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		DB00411	7581	23	None	-8	11	Mouse	4.2	pKi	=	4.2	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		71450550	90582	0	None	-1	16	Human	6.2	pKi	=	6.2	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205836	90582	0	None	-1	16	Human	6.2	pKi	=	6.2	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		156017826	184637	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4644285	184637	0	None	-3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		10408160	19822	0	None	-3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		CHEMBL1190020	19822	0	None	-3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		CHEMBL540013	19822	0	None	-3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligandBinding affinity was measured as selectivity for sigma 1 site over muscarinic (M2) receptor at 10 uM in rat using [3H]QN as radioligand	ChEMBL	391	7	0	3	5.3	O=C(OCCCN1CCC(c2ccccc2)CC1)C1(c2ccccc2)CCCC1	10.1021/jm00039a008
		44299589	203176	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL56275	203176	0	None	1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		44450624	102711	0	None	12	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		CHEMBL259344	102711	0	None	12	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	202	1	0	2	1.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)CS1	10.1016/j.bmc.2007.12.036
		11045444	65963	0	None	-2	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL170088	65963	0	None	-2	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	320	7	0	2	4.9	CCCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		11000399	65869	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL169680	65869	0	None	-1	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	278	5	0	2	3.6	CN(C)CCC1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
		463209	127910	1	None	-6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	519	5	0	6	4.8	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(OC(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		CHEMBL357557	127910	1	None	-6	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	519	5	0	6	4.8	Cc1ncnc(C)c1C(=O)N1CCC(C)(N2CCN([C@@H](C)c3ccc(OC(F)(F)F)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(02)00918-6
		134272502	183087	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4514058	183087	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4595246	183087	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	456	8	1	3	4.7	O=C(O[C@@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		44392974	71314	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	343	2	0	3	4.5	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		CHEMBL181447	71314	0	None	2	2	Human	7.2	pKi	=	7.2	Binding	In vitro inhibitory activity against cloned human M2 muscarinic receptorIn vitro inhibitory activity against cloned human M2 muscarinic receptor	ChEMBL	343	2	0	3	4.5	C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12	10.1016/j.bmcl.2004.05.047
		16086062	87566	0	None	-128	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	11	2	5	5.4	O=C(NCC1CCN(CC2CCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL215189	87566	0	None	-128	5	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	730	11	2	5	5.4	O=C(NCC1CCN(CC2CCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		44308809	211160	0	None	-123	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	3	3	2.9	NCC1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL71799	211160	0	None	-123	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	366	5	3	3	2.9	NCC1CCC(NC(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		56963799	81670	0	None	-1698	10	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
		CHEMBL2031737	81670	0	None	-1698	10	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human recombinant M2 receptorBinding affinity to human recombinant M2 receptor	ChEMBL	378	6	0	5	4.6	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc([N+](=O)[O-])cc3)ccc2o1	10.1021/jm201690h
		132060812	168815	0	None	-1778	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		CHEMBL4160064	168815	0	None	-1778	10	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
		4011	89183	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	89183	49	None	-35	24	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		44593622	194575	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL495888	194575	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL556390	194575	0	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	356	3	0	2	3.3	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])C(c2ccccc2)(c2ccccc2)O1	10.1016/j.bmc.2008.04.013
		10647553	46492	0	None	-407	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	3	4	3.6	O=C(NC1CCN(Cc2cccc(CO)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147554	46492	0	None	-407	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	458	7	3	4	3.6	O=C(NC1CCN(Cc2cccc(CO)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		44422699	18623	0	None	5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL1182272	18623	0	None	5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		CHEMBL227378	18623	0	None	5	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	174	2	0	2	0.5	C[C@@H]1COC[C@H](C[N+](C)(C)C)O1	10.1016/j.bmcl.2007.11.073
		10473919	211510	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	363	11	0	5	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccc(OC)cc2)CCCC1	10.1021/jm00041a006
		CHEMBL74305	211510	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	363	11	0	5	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccc(OC)cc2)CCCC1	10.1021/jm00041a006
		16125571	91925	0	None	-79	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		CHEMBL225074	91925	0	None	-79	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	441	6	1	3	4.6	COc1cccc(CN2CCC(N3CC(c4ccccc4)(c4ccccc4)NC3=O)CC2)c1	10.1021/jm061159a
		66561967	81479	0	None	-1	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	213	2	0	1	2.0	C1CC2CCC1N2CC12C3C4C5C3C1C5C42	10.1016/j.bmcl.2012.04.077
		CHEMBL2030626	81479	0	None	-1	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of M2 muscarinic receptorInhibition of M2 muscarinic receptor	ChEMBL	213	2	0	1	2.0	C1CC2CCC1N2CC12C3C4C5C3C1C5C42	10.1016/j.bmcl.2012.04.077
		44295888	195036	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	461	6	1	3	4.7	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL49975	195036	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	461	6	1	3	4.7	Cc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(C(=O)NC(C)C)cc3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		9815331	209886	1	None	-1	8	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		CHEMBL64000	209886	1	None	-1	8	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	169	1	1	3	0.8	CC(=O)OC1CC2CCCC1N2	10.1021/jm9904001
		174174	7311	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		260	7311	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		320	7311	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		CHEMBL517712	7311	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		DB00572	7311	49	None	-7	14	Human	8.2	pKi	=	8.2	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/acs.jmedchem.9b02172
		118710668	127612	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	127612	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	127612	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		118710668	127612	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	127612	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	127612	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		140844410	183171	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4436947	183171	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4595946	183171	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	484	10	1	3	5.5	O=C(OC1C[N+]2(CCCCCc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		71454562	86429	0	None	6	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2115126	86429	0	None	6	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		44431387	94093	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL233201	94093	0	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		164609510	195244	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4846562	195244	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5027965	195244	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	817	21	11	10	0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		10204457	211182	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	453	6	0	6	4.0	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL71971	211182	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	453	6	0	6	4.0	COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		174174	7311	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		260	7311	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		320	7311	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		CHEMBL517712	7311	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		DB00572	7311	49	None	-4	14	Rat	8.1	pKi	=	8.1	Binding	Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heartEvaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart	ChEMBL	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	10.1021/jm00402a035
		13567081	18006	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL1178839	18006	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		CHEMBL45454	18006	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human cloned muscarinic receptor M2 expressed in CHO cellsBinding affinity to human cloned muscarinic receptor M2 expressed in CHO cells	ChEMBL	320	4	0	2	4.3	C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/jm061374r
		44292563	194559	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
		CHEMBL49576	194559	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	383	6	1	4	3.1	O=C(OC1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1ccc(CCF)cc1	10.1021/jm00010a016
		71449148	86313	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		CHEMBL2114064	86313	0	None	1	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2Binding affinity against Muscarinic acetylcholine receptor M2	ChEMBL	436	6	0	4	5.5	COc1ccc([S@@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00437-6
		155523889	183303	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4454134	183303	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4597014	183303	0	None	11	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	803	21	9	9	1.8	CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		14939893	16306	0	None	-1	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		CHEMBL112244	16306	0	None	-1	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	621	24	3	7	6.2	CN(CCCCCCN)CCCCCCCCN(C)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21	10.1021/jm981038d
		CHEMBL5270925	200439	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	474	9	1	3	6.9	C#CCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		24846938	96576	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	8	1	5	3.4	CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1	10.1016/j.bmc.2013.01.072
		CHEMBL2377267	96576	0	None	-6	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	339	8	1	5	3.4	CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1	10.1016/j.bmc.2013.01.072
		10030021	176658	12	None	6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	532	10	1	4	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4440484	176658	12	None	6	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cellsBinding affinity to muscarinic M2 receptor (unknown origin) expressed in CHO cells	ChEMBL	532	10	1	4	6.1	CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		9913341	88933	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL216927	88933	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		CHEMBL553058	88933	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Compound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cellsCompound was tested for binding inhibition of [3H](R)-QNB to Muscarinic acetylcholine receptor M2 expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0301235
		156014269	183995	0	None	-10	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4635500	183995	0	None	-10	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	303	4	0	3	3.4	CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1	10.1021/acs.jmedchem.9b02100
		44319071	212798	0	None	-7	2	Human	8.1	pKi	=	8.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL84993	212798	0	None	-7	2	Human	8.1	pKi	=	8.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	404	5	0	2	5.7	O=C(c1ccccc1)N(c1ccc(Cl)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		9913341	88933	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL216927	88933	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		CHEMBL553058	88933	4	None	-3	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cellsInhibition of [3H](R)-QNB binding to human M2 receptor expressed in A9 L cells	ChEMBL	487	16	0	13	1.6	COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1	10.1021/jm0606995
		9818955	16115	1	None	2	2	Rat	8.1	pKi	=	8.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		CHEMBL111224	16115	1	None	2	2	Rat	8.1	pKi	=	8.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		205895	18640	2	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		CHEMBL118240	18640	2	None	1	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.1	O=C1CCCN1CC#CCN1CCCCC1	10.1021/jm00075a007
		55005	111552	8	None	-1	3	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL310852	111552	8	None	-1	3	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		199230	169914	21	None	37	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		CHEMBL41779	169914	21	None	37	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00075a007
		10262466	105120	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/j.bmc.2007.09.003
		CHEMBL275104	105120	0	None	3	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	208	2	0	3	0.3	O=C1CCON1CC#CCN1CCCC1	10.1016/j.bmc.2007.09.003
		10621363	128468	0	None	-48	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
		CHEMBL358726	128468	0	None	-48	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	406	6	2	3	4.2	Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1	10.1021/jm0003135
		44593625	194909	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL498358	194909	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539120	194909	0	None	-5	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		10449632	110223	0	None	-56	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	5	0	2	5.0	CCc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		CHEMBL3084898	110223	0	None	-56	2	Rat	6.2	pKi	=	6.2	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	5	0	2	5.0	CCc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccccc2)cc1	10.1021/jm00020a006
		71458105	86371	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL2114427	86371	0	None	-1	2	Rat	5.2	pKi	=	5.2	Binding	Compound was evaluated for its binding affinity towards M2 receptor in rat brainstemCompound was evaluated for its binding affinity towards M2 receptor in rat brainstem	ChEMBL	234	2	0	2	1.5	CN1CCCC[C@H]1CC#CCN1CCCC1=O	10.1021/jm00087a008
		145962050	168411	0	None	-3	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4130037	168411	0	None	-3	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		10949838	11993	0	None	-234	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.4	CCOC(=O)c1c(CC)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL106218	11993	0	None	-234	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	420	4	0	6	4.4	CCOC(=O)c1c(CC)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		73346226	99039	0	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426668	99039	0	None	-1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
		164621361	195332	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4865137	195332	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028648	195332	0	None	-2	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	775	17	11	10	-0.5	CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		14964498	20659	0	None	6	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119615	20659	0	None	6	2	Rat	7.2	pKi	=	7.2	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		10405613	209297	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	350	2	1	4	3.0	CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1016/0960-894X(96)00107-2
		CHEMBL611476	209297	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.Compound was evaluated for displacement of [3H]-QNB from human Muscarinic m2 receptor in CHO cells.	ChEMBL	350	2	1	4	3.0	CC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1016/0960-894X(96)00107-2
		14964496	15736	0	None	1	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL109815	15736	0	None	1	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		10354969	20344	15	None	-4	2	Rat	4.2	pKi	=	4.2	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
		CHEMBL1194009	20344	15	None	-4	2	Rat	4.2	pKi	=	4.2	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
		CHEMBL545506	20344	15	None	-4	2	Rat	4.2	pKi	=	4.2	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2ccc(-c3ccccc3)nn2)CC1	10.1021/jm9705418
		1273	8535	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		3450	8535	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		356	8535	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		6172	8535	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		67425	8535	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		CHEMBL360055	8535	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		DB00483	8535	16	None	-1	3	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	nan
		10088338	110215	0	None	-15	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	4	0	2	5.0	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(C)cc2)cc1	10.1021/jm00020a006
		CHEMBL3084888	110215	0	None	-15	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	335	4	0	2	5.0	Cc1ccc(C(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)c2ccc(C)cc2)cc1	10.1021/jm00020a006
		44400375	75949	0	None	-2	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	367	5	1	4	3.0	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
		CHEMBL192537	75949	0	None	-2	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	367	5	1	4	3.0	O=C(OCC#CCN1CC2CC2C1)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2005.02.036
		11767229	85692	0	None	-72	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	607	15	2	3	7.5	O=C(CCCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		CHEMBL2112956	85692	0	None	-72	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2Binding affinity (Ki) against binding of [3H]NMS to membranes from CHO cells expressing cloned human Muscarinic acetylcholine receptor M2	ChEMBL	607	15	2	3	7.5	O=C(CCCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1	10.1021/jm010480k
		9308	24526	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL1255785	24526	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL12587	24526	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		CHEMBL292911	24526	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9904001
		57339144	99013	78	None	1	6	Human	7.1	pKi	=	7.1	Binding	Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2	ChEMBL	529	6	1	5	4.8	O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1	10.6019/CHEMBL5212743
		CHEMBL2426364	99013	78	None	1	6	Human	7.1	pKi	=	7.1	Binding	Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b CHRM2	ChEMBL	529	6	1	5	4.8	O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1	10.6019/CHEMBL5212743
		3652	10869	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		57	10869	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		60809	10869	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		CHEMBL21536	10869	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		DB15357	10869	79	None	-18	18	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)indolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/acs.jmedchem.9b02172
		162353391	187600	0	None	1	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
		CHEMBL4756873	187600	0	None	1	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	282	4	1	4	2.3	O=C(CCN1CCCc2ccccc21)Nc1cccnn1	10.1016/j.bmcl.2020.127632
		44448606	18690	0	None	-12	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1182652	18690	0	None	-12	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL258385	18690	0	None	-12	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	310	6	2	3	2.6	OC(CCCN1CCNCC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		10114698	11605	0	None	-660	5	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	448	7	1	5	5.5	CCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		CHEMBL104210	11605	0	None	-660	5	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.	ChEMBL	448	7	1	5	5.5	CCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3	10.1021/jm011116o
		46227481	20911	0	None	-1	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL1198081	20911	0	None	-1	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		CHEMBL595022	20911	0	None	-1	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	202	2	0	2	1.3	C[C@H]1O[C@H](C[N+](C)(C)C)COC1(C)C	10.1016/j.bmc.2009.10.027
		16086001	145992	0	None	-426	5	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	716	11	2	5	5.0	O=C(NCC1CCN(CC2CC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		CHEMBL378772	145992	0	None	-426	5	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	716	11	2	5	5.0	O=C(NCC1CCN(CC2CC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm051205r
		16125373	91565	0	None	-28	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	2	5.2	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL223267	91565	0	None	-28	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	2	5.2	O=C1NC(c2ccccc2)(C2CCCCC2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		44318930	112949	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
		CHEMBL313738	112949	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	251	2	0	3	2.7	CN1C2CCCC1C(OC(=O)C1CCCCC1)C2	10.1021/jm9904001
		16086000	87131	0	None	-1412	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	9	2	5	4.2	CN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
		CHEMBL214342	87131	0	None	-1412	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	676	9	2	5	4.2	CN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm051205r
		9802631	118774	1	None	-3467	4	Rat	5.1	pKi	=	5.1	Binding	Compound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assayCompound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay	ChEMBL	427	7	2	4	3.7	COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm9601720
		CHEMBL328866	118774	1	None	-3467	4	Rat	5.1	pKi	=	5.1	Binding	Compound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assayCompound was tested for the Binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay	ChEMBL	427	7	2	4	3.7	COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C1	10.1021/jm9601720
		130442480	182049	0	None	-89	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	182049	0	None	-89	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		44400762	77343	0	None	-2	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	396	5	2	3	2.3	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
		CHEMBL194870	77343	0	None	-2	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	ChEMBL	396	5	2	3	2.3	O=C(NCC#CCN1CC2CC2C1)C(O)(c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2005.02.036
		3028236	109376	1	None	-1380	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL2377383	109376	1	None	-1380	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		CHEMBL3041159	109376	1	None	-1380	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	ChEMBL	340	9	0	2	4.2	CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1	10.1016/j.bmc.2013.01.072
		10336882	110225	0	None	-10	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	332	4	0	3	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C#N)cc1)C2	10.1021/jm00020a006
		CHEMBL3084900	110225	0	None	-10	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	332	4	0	3	4.3	CN1[C@H]2CC[C@@H]1C[C@H](OC(c1ccccc1)c1ccc(C#N)cc1)C2	10.1021/jm00020a006
		939078	69843	2	None	-12	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		CHEMBL1788286	69843	2	None	-12	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	335	2	0	4	3.6	O=C(O[C@@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21	10.1021/jm00402a035
		44313626	211347	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	399	7	0	4	4.8	O=C(OCOCCN1CCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		CHEMBL73017	211347	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	399	7	0	4	4.8	O=C(OCOCCN1CCCC1)C1(c2ccc(Cl)c(Cl)c2)CCCCC1	10.1021/jm00041a006
		164611347	195253	0	None	14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4856090	195253	0	None	14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028070	195253	0	None	14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		44576913	200093	0	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL524186	200093	0	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL557808	200093	0	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	336	4	0	2	3.3	C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		44274441	105869	0	None	1	5	Human	5.1	pKi	=	5.1	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL280684	105869	0	None	1	5	Human	5.1	pKi	=	5.1	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	320	5	0	4	3.1	CN(C)CCOC(=O)C1=C/C(=C\c2cccnc2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		24894625	16550	0	None	2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
		CHEMBL113580	16550	0	None	2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
		CHEMBL553155	16550	0	None	2	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	166	1	0	1	2.2	C[N+]1(C)CCC[C@H]1c1ccco1	10.1021/jm800145d
		156014813	185063	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4649668	185063	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650897	185063	0	None	-1	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	376	5	0	4	2.7	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(S(=O)(=O)c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		5282593	62032	26	None	-5	5	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		CHEMBL1319362	62032	26	None	-5	5	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		CHEMBL1618018	62032	26	None	-5	5	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	275	3	1	4	1.9	CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(O)c1ccccc1)C2	nan
		9308	24526	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	24526	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	24526	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	24526	21	None	-2	7	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		9308	24526	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL1255785	24526	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL12587	24526	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		CHEMBL292911	24526	21	None	2	7	Human	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	ChEMBL	174	2	1	2	0.2	C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O	10.1021/jm9705115
		11504244	113296	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	113296	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	113296	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	113296	0	None	199	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		164623530	195352	0	None	61	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4872632	195352	0	None	61	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028763	195352	0	None	61	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	903	21	10	13	-1.3	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		2750	210840	76	None	-4	12	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	210840	76	None	-4	12	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		44627958	20808	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197374	20808	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL569089	20808	0	None	-2	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		11718570	78977	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	376	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1Cc1ccccc1	10.1021/jm050099q
		CHEMBL198065	78977	0	None	-9	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	376	3	0	3	4.1	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1Cc1ccccc1	10.1021/jm050099q
		456292	103524	1	None	-42	2	Human	6.1	pKi	=	6.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	553	6	0	5	6.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		CHEMBL264442	103524	1	None	-42	2	Human	6.1	pKi	=	6.1	Binding	Affinity for Muscarinic acetylcholine receptor M2Affinity for Muscarinic acetylcholine receptor M2	ChEMBL	553	6	0	5	6.0	Cc1cccc(C)c1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(Cc4ccc5c(c4)OCO5)cc3)[C@@H](C)C2)CC1	10.1016/s0960-894x(01)00381-x
		44309153	210293	0	None	-69	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	4	2	3	2.5	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL66322	210293	0	None	-69	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	352	4	2	3	2.5	NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44378888	63619	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	0	8	4.3	Cc1cccnc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		CHEMBL164385	63619	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligandBinding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand	ChEMBL	590	6	0	8	4.3	Cc1cccnc1C(=O)N1CCC(N2CCN([C@@H](C)c3ccc(S(=O)(=O)c4ccc5c(c4)OCO5)cc3)[C@H](C)C2)CC1	10.1016/s0960-894x(02)00024-0
		44593626	194632	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL496306	194632	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL539121	194632	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		4212	205458	82	None	1	4	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		CHEMBL1417019	205458	82	None	1	4	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		CHEMBL58	205458	82	None	1	4	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	nan
		75201901	173204	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	173204	19	None	-575	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		71720489	93734	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323447	93734	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	303	3	0	5	2.0	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		11588241	162518	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL2092735	162518	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL405612	162518	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@+]1[O-]	10.1021/jm0510878
		45266385	202271	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		CHEMBL553241	202271	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		7047822	183615	15	None	-3	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc([C@H]2CCCN2)c1	10.1021/jm800145d
		CHEMBL461088	183615	15	None	-3	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	137	1	1	2	1.7	c1coc([C@H]2CCCN2)c1	10.1021/jm800145d
		10026270	100890	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	440	6	2	3	4.5	O=C(N[C@H]1[C@@H]2CN(Cc3ccc4ccccc4c3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL249206	100890	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	440	6	2	3	4.5	O=C(N[C@H]1[C@@H]2CN(Cc3ccc4ccccc4c3)C[C@@H]21)C(O)(c1ccccc1)C1CCCC1	10.1016/j.bmcl.2007.06.081
		44295668	195734	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	462	6	2	4	4.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4N)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL50822	195734	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	462	6	2	4	4.0	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccccc4N)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		10336644	168452	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	328	3	1	3	3.4	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1	10.1021/jm970333f
		CHEMBL41313	168452	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	ChEMBL	328	3	1	3	3.4	C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1	10.1021/jm970333f
		14956860	20474	1	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		CHEMBL1194903	20474	1	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		CHEMBL553520	20474	1	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Tested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membraneTested against muscarinic M2 receptor by displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane	ChEMBL	212	1	0	4	0.5	CCN1C(=O)OC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		44406480	79619	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		CHEMBL200210	79619	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human muscarinic M2 receptorBinding affinity to human muscarinic M2 receptor	ChEMBL	348	3	1	4	2.4	COC1(C#CC(O)(c2ccccc2)c2ccccn2)CN2CCC1CC2	10.1016/j.bmcl.2005.09.079
		10834711	128188	0	None	-21	3	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	4	3.9	O=C(NC1CCN(Cc2ccsc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL358193	128188	0	None	-21	3	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	398	6	2	4	3.9	O=C(NC1CCN(Cc2ccsc2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		155551903	183236	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4569929	183236	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4596435	183236	0	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	462	8	2	4	4.3	CCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		118719931	122563	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	669	18	0	4	8.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)CC1	10.1021/jm501173q
		CHEMBL3354078	122563	0	None	-2	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	669	18	0	4	8.7	O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)CC1	10.1021/jm501173q
		44319339	212686	0	None	-44	2	Human	7.1	pKi	=	7.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL83982	212686	0	None	-44	2	Human	7.1	pKi	=	7.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	386	5	1	3	4.7	O=C(c1ccccc1)N(c1ccc(O)cc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		137631026	167929	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4093215	167929	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
		CHEMBL4117321	167929	0	None	-2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	230	1	0	1	3.0	C[N+](C)(C)C1CCc2ccc3ccoc3c2C1	10.1021/acs.jmedchem.7b01113
		2200	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		328	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		4848	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		CHEMBL9967	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		DB00670	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Affinity constant measured against M2 muscarinic receptor in rat heart rAffinity constant measured against M2 muscarinic receptor in rat heart r	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00075a032
		12310489	215173	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00566-8
		CHEMBL99618	215173	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilateBinding affinity against the muscarinic M2 (brainstem) subtype was evaluated using [3H]quinuclidinyl benzilate	ChEMBL	345	2	0	3	4.4	C[C@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@H]3[C@H](/C=C/[C@@H]3CCC[C@@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00566-8
		2200	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		328	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		4848	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		CHEMBL9967	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		DB00670	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat HeartCompound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00403-G
		137640201	163740	2	None	-630	13	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	362	6	0	2	4.3	O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		CHEMBL4072818	163740	2	None	-630	13	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method	ChEMBL	362	6	0	2	4.3	O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.8b00265
		42853213	111121	7	None	-7	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	360	5	0	3	4.6	O=C(c1ccco1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL310016	111121	7	None	-7	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	360	5	0	3	4.6	O=C(c1ccco1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		2396803	212905	3	None	-10	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	398	7	0	2	5.3	O=C(CCc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		CHEMBL85950	212905	3	None	-10	2	Human	6.1	pKi	=	6.1	Binding	In vitro affinity for muscarinic M2 receptor.In vitro affinity for muscarinic M2 receptor.	ChEMBL	398	7	0	2	5.3	O=C(CCc1ccccc1)N(c1ccccc1)C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(02)00487-0
		2200	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		328	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		4848	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		CHEMBL9967	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		DB00670	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenatesInhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1016/0960-894X(95)00113-8
		2200	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		328	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		4848	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		CHEMBL9967	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		DB00670	9905	46	None	-31	13	Rat	6.1	pKi	=	6.1	Binding	Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMSTested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS	ChEMBL	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	10.1021/jm00046a021
		9818955	16115	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		CHEMBL111224	16115	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	The compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligandThe compound was tested in vitro for binding activity against M2 muscarinic receptor in homogenates of the brainstem of rat using [3H]quinuclidinyl benzilate (QNB) as radioligand	ChEMBL	331	2	0	3	4.0	C[C@H]1CCC[C@H](/C=C/[C@@H]2[C@H]3CCCC[C@@H]3C[C@@H]3C(=O)OC[C@@H]32)N1C	10.1016/s0960-894x(02)00695-9
		2736067	94305	73	None	-93	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysis	ChEMBL	230	1	1	2	2.4	Clc1cc(Cl)cc(N2CCNCC2)c1	10.1021/jm400140q
		CHEMBL2335158	94305	73	None	-93	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysisDisplacement of [3H]-NMS from recombinant muscarinic M2 receptor (unknown origin) expressed in CHOK1 cells after 60 mins by liquid scintillation counting analysis	ChEMBL	230	1	1	2	2.4	Clc1cc(Cl)cc(N2CCNCC2)c1	10.1021/jm400140q
		57326239	83957	0	None	-5	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042551	83957	0	None	-5	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078974	83957	0	None	-5	5	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1COC[C@@H](C(c2ccccc2)c2ccccc2)O1	10.1021/jm2013216
		2551	7581	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		298	7581	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		488	7581	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		CHEMBL965	7581	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		DB00411	7581	23	None	-8	11	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	ChEMBL	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	10.1021/jm00095a008
		350	10329	7	None	26	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
		9867750	10329	7	None	26	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
		CHEMBL73341	10329	7	None	26	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10.1016/s0960-894x(00)00438-8
		2028	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		359	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		4634	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		CHEMBL1231	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		DB01062	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1016/j.bmcl.2006.11.058
		164619081	195316	0	None	4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4872720	195316	0	None	4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028531	195316	0	None	4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	718	18	8	9	1.9	CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1016/j.ejmech.2021.113159
		118710668	127612	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3323283	127612	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3558234	127612	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	619	15	1	6	3.8	C[N+](C)(CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		3652	10869	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		57	10869	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		60809	10869	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		CHEMBL21536	10869	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		DB15357	10869	79	None	-18	18	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1021/jm501173q
		118710664	127610	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323281	127610	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558231	127610	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	683	15	1	5	6.6	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		10963509	25268	1	None	1	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	687	17	0	6	8.6	COc1ccccc1CN1CCC(C2CCN(CCCCCCCCN3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
		CHEMBL127273	25268	1	None	1	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2Binding affinity against muscarinic acetylcholine receptor M2	ChEMBL	687	17	0	6	8.6	COc1ccccc1CN1CCC(C2CCN(CCCCCCCCN3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
		44267744	22220	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL12153	22220	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	504	6	0	3	7.0	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4cccc5ccc(F)cc45)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		11155732	17319	17	None	-26	3	Rat	8.1	pKi	=	8.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL1169543	17319	17	None	-26	3	Rat	8.1	pKi	=	8.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	362	2	0	3	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@H]1c1ccccc1	10.1021/jm050099q
		10104167	8840	2	None	13	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		6937	8840	2	None	13	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		CHEMBL3121473	8840	2	None	13	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	197	2	0	3	0.4	C[N+](CC#CCOC1=NOCC1)(C)C	10.1021/jm500790x
		44431386	155804	0	None	1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL394255	155804	0	None	1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		16125587	91538	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.6	C[N+]1(CCCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL223028	91538	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	456	8	1	2	4.6	C[N+]1(CCCOc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		118710670	127611	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3323284	127611	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		CHEMBL3558233	127611	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	697	15	1	6	5.5	CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21	10.1021/jm500790x
		55005	111552	8	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		CHEMBL310852	111552	8	None	-1	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	208	2	0	2	1.0	CC(=O)N(C)C(C)C#CCN1CCCC1	10.1021/jm00075a007
		14964496	15736	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL109815	15736	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	CC1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL69452	210753	0	None	2	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	331	6	1	5	2.7	CCO/C(O)=C1\CN2CC(CCC2COCc2ccccc2)C1=O	10.1021/jm020572p
		11718536	144623	0	None	-41	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	411	5	1	2	4.6	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL376000	144623	0	None	-41	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	411	5	1	2	4.6	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		574784	110372	2	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	379	3	0	5	2.0	CCN1C(=O)c2ccccc2N(C(=O)CN2CCN(C)CC2)c2ncccc21	10.1021/jm00111a032
		CHEMBL308650	110372	2	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membranes.	ChEMBL	379	3	0	5	2.0	CCN1C(=O)c2ccccc2N(C(=O)CN2CCN(C)CC2)c2ncccc21	10.1021/jm00111a032
		10354968	19847	1	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
		CHEMBL1190173	19847	1	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
		CHEMBL540310	19847	1	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.Compound was evaluated for its binding affinity for Muscarinic acetylcholine receptor M2 by measuring displacement of [3H]- NMS ligand from rat cardiac cells.	ChEMBL	254	2	0	4	1.9	CN1CCN(c2cc(-c3ccccc3)cnn2)CC1	10.1021/jm9705418
		107867	9748	55	None	2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
		309	9748	55	None	2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
		CHEMBL17045	9748	55	None	2	11	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human M2 muscarinic receptorBinding affinity to human M2 muscarinic receptor	ChEMBL	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	10.1021/jm301774u
		164614830	195279	0	None	46	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4858774	195279	0	None	46	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028275	195279	0	None	46	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	889	20	10	13	-1.7	CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		130442572	178687	0	None	-173	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	178687	0	None	-173	24	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-QNB/[3H]-NMS from human muscarinic M2 receptor expressed in stable CHO cells after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		10365534	161739	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	7	2	3	4.0	Cc1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1C	10.1016/j.bmcl.2007.06.081
		CHEMBL401154	161739	0	None	-18	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	432	7	2	3	4.0	Cc1ccc(CCN2C[C@H]3[C@H](NC(=O)C(O)(c4ccccc4)C4CCCC4)[C@H]3C2)cc1C	10.1016/j.bmcl.2007.06.081
		11530307	85117	0	None	1	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2093082	85117	0	None	1	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2109993	85117	0	None	1	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@H]1O[C@@H]([C@@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		45266386	201695	0	None	1	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		CHEMBL541424	201695	0	None	1	3	Human	4.1	pKi	=	4.1	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		44286173	151265	0	None	3	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	194	3	0	2	0.6	CCN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL39068	151265	0	None	3	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	194	3	0	2	0.6	CCN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
		16125223	175678	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
		CHEMBL438427	175678	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	397	5	1	2	4.2	O=C1NC(c2ccccc2)(c2ccccc2)CN1[C@@H]1CCN(Cc2ccccc2)C1	10.1021/jm061159a
		44308900	210775	0	None	-85	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	367	5	2	4	1.4	NCCN1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		CHEMBL69582	210775	0	None	-85	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cellsBinding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells	ChEMBL	367	5	2	4	1.4	NCCN1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1	10.1016/s0960-894x(03)00350-0
		44318929	113639	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
		CHEMBL314493	113639	0	None	-2	4	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneInhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
		CHEMBL5092328	222138	5	None	-6	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-AF-DX 384 from human recombinant muscarinic 2 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-AF-DX 384 from human recombinant muscarinic 2 receptor after 60 mins by scintillation counting analysis	ChEMBL		None	None	None		CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N	10.1021/acs.jmedchem.1c00935
		3236	74383	43	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
		CHEMBL1902981	74383	43	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	nan
		36381	19714	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmcl.2012.08.046
		CHEMBL1189234	19714	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmcl.2012.08.046
		36381	19714	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmc.2013.07.045
		CHEMBL1189234	19714	5	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	265	2	1	2	1.9	OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccccc1	10.1016/j.bmc.2013.07.045
		302	9751	25	None	-4	8	Rat	7.1	pKi	=	7.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
		4630	9751	25	None	-4	8	Rat	7.1	pKi	=	7.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
		CHEMBL7634	9751	25	None	-4	8	Rat	7.1	pKi	=	7.1	Binding	Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/jm00087a008
		15050954	210782	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	524	6	1	7	2.6	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL69620	210782	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	524	6	1	7	2.6	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		71718048	93730	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323443	93730	0	None	-1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		9948957	211271	1	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	319	11	0	3	3.9	CCN(CC)CCOCCOCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		CHEMBL72506	211271	1	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	319	11	0	3	3.9	CCN(CC)CCOCCOCC1(c2ccccc2)CCCC1	10.1021/jm00041a006
		118719924	122556	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	649	20	0	7	8.4	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354071	122556	0	None	-5	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	649	20	0	7	8.4	CN1CCC=C(c2nsnc2OCCCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		44593624	194908	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL498357	194908	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL554916	194908	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		9842753	208591	0	None	-24	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@@H](O)c2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
		CHEMBL606963	208591	0	None	-24	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	378	2	1	4	3.4	O=C(O[C@H]1CN2CCC1CC2)N1C[C@@H](O)c2ccccc2[C@@H]1c1ccccc1	10.1021/jm050099q
		10101246	16318	0	None	-81	2	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		CHEMBL112297	16318	0	None	-81	2	Human	6.1	pKi	=	6.1	Binding	Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayAbility to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay	ChEMBL	701	34	2	6	10.1	CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1	10.1016/s0960-894x(99)00604-6
		44299564	205866	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL58824	205866	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@H]3[C@H](/C=C\[C@H]3CCC[C@H](C)N3C)[C@@H]12	10.1016/s0960-894x(02)00315-3
		11759379	127555	0	None	2	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	332	5	0	2	5.1	CC(C1=C(CCN2CCCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL355392	127555	0	None	2	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	332	5	0	2	5.1	CC(C1=C(CCN2CCCCC2)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		167962	10841	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		362	10841	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		CHEMBL31599	10841	4	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	10.1021/acs.jmedchem.9b02172
		302	9751	25	None	-34	8	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		4630	9751	25	None	-34	8	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		CHEMBL7634	9751	25	None	-34	8	Human	6.1	pKi	=	6.1	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)piperazin-1-yl)ethyl)amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Bis(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	10.1021/acs.jmedchem.9b02172
		123603	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		2684	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		584	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		9658	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		CHEMBL168815	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysisDisplacement of [3H]NMS from human muscarinic M2 receptor transfected in CHO cells after 120 mins by scintillation counting analysis	ChEMBL	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	10.1016/j.bmcl.2014.06.020
		2398	7741	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	7741	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	7741	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	7741	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	7741	62	None	-3	29	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		10574041	46596	0	None	-281	3	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	418	6	2	4	3.7	O=C(NC1CCN(Cc2ccoc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL147695	46596	0	None	-281	3	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	418	6	2	4	3.7	O=C(NC1CCN(Cc2ccoc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1	10.1021/jm0003135
		CHEMBL308924	110564	0	None	-2	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandBinding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand	ChEMBL	268	4	1	5	1.0	CCO/C(O)=C1\CN2CC(CCC2CN(C)C)C1=O	10.1021/jm020572p
		71716225	93732	0	None	1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323445	93732	0	None	1	2	Rat	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	317	4	0	5	1.9	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)Cc3ccccc3)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		16125325	91348	0	None	-2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	336	3	1	1	2.8	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222090	91348	0	None	-2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	336	3	1	1	2.8	C[N+]1(C)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		2229	7252	22	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
		295	7252	22	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
		CHEMBL128365	7252	22	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	10.1021/jm0510878
		44627956	20806	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL1197362	20806	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		CHEMBL568775	20806	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells by scintillation counting	ChEMBL	354	4	1	2	5.0	C[N+]1(C)CCC[C@@H]1c1ccc([C@@](O)(c2ccccc2)C2CCCCC2)o1	10.1021/jm901048j
		1687	111186	20	None	-15	5	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL310310	111186	20	None	-15	5	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		CHEMBL540034	111186	20	None	-15	5	Rat	7.1	pKi	=	7.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	ChEMBL	341	4	0	2	5.1	CN1C2CCC1CC(OC(c1ccccc1)c1ccc(Cl)cc1)C2	10.1021/jm00020a006
		3072501	114046	6	None	-	1	Mouse	6.1	pKi	=	6.1	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL316973	114046	6	None	-	1	Mouse	6.1	pKi	=	6.1	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	ChEMBL	380	10	1	8	3.5	CN(C)Cc1ccc(CSCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		53390181	99046	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426675	99046	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
		53390538	99052	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426681	99052	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
		44448421	19109	0	None	-11	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL1185269	19109	0	None	-11	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		CHEMBL403773	19109	0	None	-11	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	616	13	2	4	7.8	OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2008.03.061
		156013387	185040	0	None	-1	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4638935	185040	0	None	-1	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650725	185040	0	None	-1	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	326	5	0	2	3.3	C[N+](C)(C)C[C@@H]1CO[C@@H](C(c2ccccc2)c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		156012563	185027	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4637485	185027	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650635	185027	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	236	3	0	2	1.8	C[N+](C)(C)C[C@@H]1CO[C@H](c2ccccc2)CO1	10.1021/acs.jmedchem.9b02100
		156013998	185048	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4635148	185048	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		CHEMBL4650787	185048	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting methodDisplacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes incubated for 2 hrs by scintillation counting method	ChEMBL	312	4	0	2	3.5	C[N+](C)(C)C[C@@H]1COC[C@H](c2ccc(-c3ccccc3)cc2)O1	10.1021/acs.jmedchem.9b02100
		11672895	84580	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@H]1O[C@@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL2092737	84580	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@H]1O[C@@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
		71452384	90572	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmcl.2012.08.046
		CHEMBL2205816	90572	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to M2 muscarinic receptorBinding affinity to M2 muscarinic receptor	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmcl.2012.08.046
		71452384	90572	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmc.2013.07.045
		CHEMBL2205816	90572	0	None	-4	5	Human	6.1	pKi	=	6.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	1	3	1.4	OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1	10.1016/j.bmc.2013.07.045
		44437295	18665	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
		CHEMBL1182472	18665	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
		CHEMBL239866	18665	0	None	4	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]QNB from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	222	2	0	4	1.2	C(#CCN1CCCCC1)COC1=NOCC1	10.1016/j.bmc.2007.09.003
		16125704	91439	0	None	-54	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222450	91439	0	None	-54	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	482	6	1	3	4.4	C[N+]1(CC(=O)c2ccsc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		71720488	93728	0	None	-13	3	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323441	93728	0	None	-13	3	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		15050952	210275	0	None	1	3	Rat	5.1	pKi	=	5.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	507	9	3	7	1.0	CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		CHEMBL66177	210275	0	None	1	3	Rat	5.1	pKi	=	5.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	507	9	3	7	1.0	CC(=O)NCCCC(=O)NCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1	10.1021/jm00111a032
		16125531	91131	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL221775	91131	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	412	5	1	1	4.4	C[N+]1(Cc2ccccc2)CC[C@@H](N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		73355416	99312	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	0	3	1.8	CN(Cc1cccnc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		CHEMBL2432043	99312	0	None	-1	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of muscarinic M2 receptor (unknown origin) by PDSP assayInhibition of muscarinic M2 receptor (unknown origin) by PDSP assay	ChEMBL	280	3	0	3	1.8	CN(Cc1cccnc1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21	10.1016/j.bmc.2013.07.045
		15050955	109375	0	None	1	4	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	538	7	1	7	3.0	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		CHEMBL304112	109375	0	None	1	4	Rat	7.1	pKi	=	7.1	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	538	7	1	7	3.0	O=C1Nc2cccnc2N(C(=O)CN2CCN(CCCCN3C(=O)c4ccccc4C3=O)CC2)c2ccccc21	10.1021/jm00111a032
		164622017	195337	0	None	47	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL4871563	195337	0	None	47	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		CHEMBL5028681	195337	0	None	47	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	917	22	10	13	-0.9	CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1	10.1016/j.ejmech.2021.113159
		109014373	186581	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
		CHEMBL4744856	186581	1	None	3	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	286	3	0	2	3.1	CC1CCN(C(=O)CCN2CCCc3ccccc32)CC1	10.1016/j.bmcl.2020.127632
		118719923	122555	0	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	621	18	0	7	7.6	CN1CCC=C(c2nsnc2OCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		CHEMBL3354070	122555	0	None	-13	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assayDisplacement of [3H]NMS from human M2 receptor expressed in CHO cells by microplate scintillation counting based radioligand binding assay	ChEMBL	621	18	0	7	7.6	CN1CCC=C(c2nsnc2OCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1	10.1021/jm501173q
		14964498	20659	0	None	6	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119615	20659	0	None	6	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		11694119	122265	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@@H]1O[C@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
		CHEMBL3351105	122265	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	203	1	0	3	0.6	C[C@@H]1O[C@H]([C@@H]2CCCN2C)C[S@+]1[O-]	10.1021/jm0510878
		46227417	20900	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL1198048	20900	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		CHEMBL593864	20900	0	None	-	1	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	C[C@@H]1OC[C@@H](C[N+](C)(C)C)O[C@@H]1C	10.1016/j.bmc.2009.10.027
		44296096	108674	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	519	6	1	5	4.4	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		CHEMBL300845	108674	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	519	6	1	5	4.4	Cc1ccccc1C(=O)N1CCC(N2CCC(C3(c4ccc(C(=O)NC(C)C)cc4)OCCO3)CC2)CC1	10.1016/j.bmcl.2004.01.033
		44295763	195594	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		CHEMBL50618	195594	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	476	6	2	4	4.3	Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(C(=O)NC(C)C)cc4)CC3)CC2)c1N	10.1016/j.bmcl.2004.01.033
		44296006	196510	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5c(F)cccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		CHEMBL51574	196510	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against cloned human muscarinic acetylcholine receptor M2.Binding affinity against cloned human muscarinic acetylcholine receptor M2.	ChEMBL	533	6	1	3	5.8	CC(C)NC(=O)c1ccc(CC2CCN(C3CCN(C(=O)c4ccc(F)c5c(F)cccc45)CC3)CC2)cc1	10.1016/j.bmcl.2004.01.033
		15407072	63640	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	471	5	1	7	3.1	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCNCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		CHEMBL164397	63640	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human cloned Muscarinic acetylcholine receptor M2.Binding affinity against human cloned Muscarinic acetylcholine receptor M2.	ChEMBL	471	5	1	7	3.1	C[C@@H](c1ccc(S(=O)(=O)c2ccc3c(c2)OCO3)cc1)N1CCN(C2CCNCC2)C[C@H]1C	10.1016/s0960-894x(02)00023-9
		9889312	85205	0	None	2	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		CHEMBL2111540	85205	0	None	2	5	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2	ChEMBL	437	6	0	5	4.4	COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1	10.1016/s0960-894x(00)00438-8
		44455198	104433	0	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1016/j.bmcl.2007.11.022
		CHEMBL271108	104433	0	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1016/j.bmcl.2007.11.022
		44455198	104433	0	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1021/acs.jmedchem.8b00041
		CHEMBL271108	104433	0	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodDisplacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting method	ChEMBL	899	22	3	7	10.3	CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C	10.1021/acs.jmedchem.8b00041
		44292834	108233	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
		CHEMBL297683	108233	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384	ChEMBL	463	4	1	4	3.2	O=C(OC1CN2CCC1CC2)[C@](O)(c1ccccc1)c1ccc(I)cc1	10.1021/jm00010a016
		44325003	118419	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	618	8	0	8	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		CHEMBL328550	118419	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.	ChEMBL	618	8	0	8	4.5	CCCS(=O)(=O)N1CCC(N2CCC(C3(c4ccc([S+]([O-])c5ccc6c(c5)OCO6)cc4)O[C@H](C)[C@@H](C)O3)CC2)CC1	10.1016/s0960-894x(00)00553-9
		10865439	27397	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	715	15	0	6	7.6	COc1ccccc1CN1CCC(C2CCN(C(=O)CCCCCCC(=O)N3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
		CHEMBL130835	27397	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cellsAffinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells	ChEMBL	715	15	0	6	7.6	COc1ccccc1CN1CCC(C2CCN(C(=O)CCCCCCC(=O)N3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1	10.1021/jm0155594
		140844398	183140	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4470924	183140	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		CHEMBL4595692	183140	0	None	2	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting methodDisplacement of [3H]NMS from human M2R expressed in CHOK1 cell membranes incubated for 2 hrs by microbeta scintillation counting method	ChEMBL	534	8	1	3	5.5	O=C(OC1C[N+]2(CCCc3cccc(Br)c3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1	10.1016/j.bmc.2019.06.016
		71128	103585	25	None	-17	8	Human	8.0	pKi	=	8.0	Binding	Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00085a017
		CHEMBL26505	103585	25	None	-17	8	Human	8.0	pKi	=	8.0	Binding	Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeAntimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtype	ChEMBL	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	10.1021/jm00085a017
		CHEMBL5265833	200236	0	None	-28	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	488	10	1	3	7.1	C#CCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1	10.1021/acs.jmedchem.2c01376
		155543345	183465	0	None	6	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4543584	183465	0	None	6	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		CHEMBL4598362	183465	0	None	6	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodDisplacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting method	ChEMBL	810	19	7	9	3.5	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1	10.1021/acs.jmedchem.8b01967
		101720828	103895	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		16147087	103895	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL1202002	103895	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		CHEMBL267643	103895	0	None	1	5	Rat	8.0	pKi	=	8.0	Binding	Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2	ChEMBL	1375	31	4	16	12.2	CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CCCCCCN(CC(=O)N1c2ccccc2NC(=O)c2cccnc21)CC(=O)N1c2ccccc2NC(=O)c2cccnc21	10.1021/jm981038d
		4841	74201	5	None	-1	5	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		CHEMBL1889399	74201	5	None	-1	5	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		CHEMBL1909073	74201	5	None	-1	5	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	368	7	1	3	3.5	CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1	nan
		11968014	19530	5	None	-4	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
		CHEMBL1187846	19530	5	None	-4	9	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cellsDisplacement of [3H]NMS from human M2 muscarinic receptor expressed in CHO-K1 cells	ChEMBL	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	10.1021/jm301774u
		10302719	50282	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	548	5	0	4	6.3	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
		CHEMBL150845	50282	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Muscarinic acetylcholine receptor M2Binding affinity for human Muscarinic acetylcholine receptor M2	ChEMBL	548	5	0	4	6.3	CC(=C1CCN(C2CCN(C(=O)c3ccc(F)c4ccccc34)CC2)CC1)c1ccc(S(=O)(=O)C(C)C)cc1	10.1021/jm0255163
		CHEMBL5271406	200460	0	None	-10	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1159	27	3	10	12.8	CC1(C)C(/C=C/C=C/C=C2/N(CCCCS(=O)(=O)O)c3ccccc3C2(C)C)=[N+](CCCCCC(=O)NCCCCCCCCN2CCC(OC(=O)Nc3ccc(F)cc3-c3ccc(F)c(Cl)c3)CC2)c2ccc(S(=O)(=O)[O-])cc21	10.1021/acs.jmedchem.2c01376
		2028	9753	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		359	9753	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		4634	9753	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		CHEMBL1231	9753	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		DB01062	9753	80	None	-8	11	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
		118710662	127608	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	127608	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	127608	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		118710662	127608	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3323280	127608	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		CHEMBL3558229	127608	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	633	15	1	5	5.4	CC(C)(CN1C(=O)c2ccccc2C1=O)C[N+](C)(C)CCCCCC[N+]1(C)[C@@H]2CC[C@@H]1CC(OC(=O)C(CO)c1ccccc1)C2	10.1021/jm500790x
		57326326	83953	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042553	83953	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078942	83953	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		57326326	83953	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL2042553	83953	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL2078942	83953	0	None	-7	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL5267836	200317	0	None	-4	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1038	20	1	13	9.8	CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1	10.1021/acs.jmedchem.2c01376
		CHEMBL5289083	201237	0	None	-5	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	1002	24	3	6	13.3	CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCNCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21	10.1021/acs.jmedchem.2c01376
		16125591	91473	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	455	6	2	2	3.8	C[N+]1(CC(=O)Nc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL222634	91473	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	455	6	2	2	3.8	C[N+]1(CC(=O)Nc2ccccc2)CCC(N2CC(c3ccccc3)(c3ccccc3)NC2=O)C1	10.1021/jm061160+
		14964494	18729	1	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		CHEMBL118292	18729	1	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	220	2	0	2	1.0	C[C@@H]1CCN(CC#CCN2CCCC2)C1=O	10.1021/jm00075a007
		155672	11809	3	None	7	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL105198	11809	3	None	7	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		CHEMBL56734	11809	3	None	7	3	Rat	7.1	pKi	=	7.1	Binding	Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heartBinding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart	ChEMBL	172	2	0	2	0.4	C[C@@H]1O[C@H](C[N+](C)(C)C)CC1=O	10.1021/jm00088a029
		44431367	94757	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		CHEMBL234252	94757	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	ChEMBL	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	10.1016/j.bmcl.2006.11.058
		44318766	212530	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
		CHEMBL82754	212530	0	None	-4	4	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	237	2	1	3	2.4	O=C(OC1CC2CCCC1N2)C1CCCCC1	10.1021/jm9904001
		16124710	91960	0	None	-54	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	0	3	5.0	O=C1OC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL225387	91960	0	None	-54	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	412	5	0	3	5.0	O=C1OC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		60138186	127614	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		60138193	127614	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3323288	127614	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		CHEMBL3558240	127614	0	None	23	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	325	9	0	3	2.1	C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCOC1=NOCC1	10.1021/jm500790x
		11504244	113296	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		60138185	113296	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3121474	113296	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		CHEMBL3140249	113296	0	None	199	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingDisplacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation counting	ChEMBL	498	13	0	5	3.1	C[N+](C)(CC#CCOC1=NOCC1)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O	10.1021/jm500790x
		303	9752	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		4629	9752	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		8595	9752	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		CHEMBL44674	9752	17	None	1	6	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]QNB radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	10.1021/jm00075a007
		170332	167755	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	167755	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	167755	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		11024241	127079	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	338	6	0	3	4.9	CSc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		CHEMBL352723	127079	0	None	-1	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	338	6	0	3	4.9	CSc1ccc2c(c1)C(C(C)c1ccccn1)=C(CCN(C)C)C2	10.1021/jm020895l
		73346227	99044	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		CHEMBL2426673	99044	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation countingDisplacement of N-methyl [3H]-scopolamine from recombinant human muscarinic acetylcholine receptor M2 expressed in CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	485	7	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](c2ccc(-c4ncccn4)cc2)C(C)C)C3)nc1	10.1016/j.bmcl.2013.07.044
		162353382	188513	0	None	4	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
		CHEMBL4777127	188513	0	None	4	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	330	4	1	2	4.6	O=C(CCN1CCCc2ccccc21)Nc1cccc2ccccc12	10.1016/j.bmcl.2020.127632
		44274417	105670	0	None	2	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		CHEMBL279225	105670	0	None	2	5	Human	5.0	pKi	=	5.0	Binding	Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.	ChEMBL	333	5	0	3	3.0	CN(C)CCN(C)C(=O)C1=C/C(=C\c2ccccn2)c2ccccc21	10.1016/s0960-894x(01)00186-x
		57664406	9177	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		6938	9177	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089376	9177	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)-amino)hexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonateHydrotrifluoroacetate fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		170332	167755	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4091934	167755	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4115997	167755	1	None	3	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillation counting method	ChEMBL	194	4	0	1	1.9	COc1cccc(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		3158	63041	27	None	-630	20	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	63041	27	None	-630	20	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL5274390	200592	0	None	-32	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysisDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in human HEK293T cell membranes by radioligand competition binding based analysis	ChEMBL	366	3	2	3	4.6	O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OC1CCNCC1	10.1021/acs.jmedchem.2c01376
		44318929	113639	0	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
		CHEMBL314493	113639	0	None	-2	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesInhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranes	ChEMBL	315	2	0	4	3.1	CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2	10.1021/jm9904001
		10105880	44225	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	1	4	1.7	OC1(c2nc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
		CHEMBL145533	44225	0	None	-5	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	244	1	1	4	1.7	OC1(c2nc3ccccc3o2)CN2CCC1CC2	10.1021/jm00003a011
		137628800	167773	0	None	-1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4089027	167773	0	None	-1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116151	167773	0	None	-1	3	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	248	4	0	1	2.8	C[N+](C)(C)CCc1cccc(OC(F)(F)F)c1	10.1021/acs.jmedchem.7b01113
		44267699	20447	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	426	6	0	4	5.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccco4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		CHEMBL11947	20447	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.Binding affinity against muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-QNB as radioligand.	ChEMBL	426	6	0	4	5.3	CC(C)Sc1ccc(CC2CCN(C3CCN(C(=O)c4ccco4)CC3)CC2)cc1	10.1016/s0960-894x(02)00096-3
		199230	169914	21	None	37	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
		CHEMBL41779	169914	21	None	37	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstemCompound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem	ChEMBL	180	2	0	2	0.2	CN(C)CC#CCN1CCCC1=O	10.1021/jm00087a008
		16125509	176121	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	3	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccs2)CC1	10.1021/jm061159a
		CHEMBL441873	176121	0	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	417	5	1	3	4.7	O=C1NC(c2ccccc2)(c2ccccc2)CN1C1CCN(Cc2cccs2)CC1	10.1021/jm061159a
		11501540	140381	0	None	-16	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
		CHEMBL371293	140381	0	None	-16	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	ChEMBL	368	2	0	4	3.9	O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2C1c1cccs1	10.1021/jm050099q
		137628788	167771	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4085150	167771	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		CHEMBL4116149	167771	0	None	1	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	220	2	0	1	2.3	COc1cccc2c1CC([N+](C)(C)C)CC2	10.1021/acs.jmedchem.7b01113
		10670961	47406	0	None	-66	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)nc1	10.1021/jm0003135
		CHEMBL148404	47406	0	None	-66	3	Human	6.0	pKi	=	6.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	444	6	3	5	3.1	Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)nc1	10.1021/jm0003135
		14964498	20659	0	None	6	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		CHEMBL119615	20659	0	None	6	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.Binding affinity at [3H]QNB and GppNHp radiolabeled muscarinic M2 receptor in rat heart.	ChEMBL	194	2	0	2	0.4	C[C@@H]1CCN(CC#CCN(C)C)C1=O	10.1021/jm00075a007
		191	7191	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	7191	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	7191	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	7191	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	7191	98	None	-56	29	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		44275807	105746	0	None	-851	10	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		CHEMBL27979	105746	0	None	-851	10	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards human muscarinic M2 receptorBinding affinity towards human muscarinic M2 receptor	ChEMBL	422	7	0	4	4.5	C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1	10.1016/s0960-894x(03)00118-5
		11653112	85108	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2092820	85108	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		CHEMBL2109828	85108	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cellsBinding affinity to cloned human muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@H]2CCC[N+]2(C)C)C[S@@+]1[O-]	10.1021/jm0510878
		45266386	201695	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		CHEMBL541424	201695	0	None	1	3	Human	5.0	pKi	=	5.0	Binding	Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsBinding affinity to human cloned muscarinic M2 receptor expressed in CHO cells	ChEMBL	218	1	0	2	0.7	C[C@@H]1O[C@H]([C@@H]2CCC[N+]2(C)C)C[S+]1[O-]	10.1016/j.bmc.2007.12.036
		57664406	9177	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		6938	9177	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		CHEMBL4089376	9177	50	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assayDisplacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4-yl)butyl)-1H-imidazol-4-yl)propanamido)ethyl)carbamoyl)benzyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-3,3-dimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate Tris(hydrotrifluoroacetate) fluorescent tracer from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plate reader assay	ChEMBL	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	10.1021/acs.jmedchem.9b02172
		11110049	65014	0	None	-2	4	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
		CHEMBL168223	65014	0	None	-2	4	Human	4.0	pKi	=	4.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	321	6	1	3	2.3	CN(C)CCNC(=O)C1=C(Cc2ccncc2)c2ccccc2C1	10.1021/jm020895l
		13773340	86365	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		CHEMBL2114396	86365	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	ChEMBL	275	3	1	4	1.5	C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1	10.1021/jm00402a035
		3823	56995	42	None	-44	11	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	56995	42	None	-44	11	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	56995	42	None	-44	11	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		16086005	146009	0	None	-77	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	724	10	3	5	5.8	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		CHEMBL378859	146009	0	None	-77	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cellsInhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells	ChEMBL	724	10	3	5	5.8	O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1	10.1021/jm051205r
		16125646	143749	0	None	-50	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	476	6	1	2	4.3	C[N+]1(CC(=O)c2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		CHEMBL374513	143749	0	None	-50	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHOK1 cells	ChEMBL	476	6	1	2	4.3	C[N+]1(CC(=O)c2ccccc2)CC[C@@H](N2CC(c3ccc(F)cc3)(c3ccc(F)cc3)NC2=O)C1	10.1021/jm061160+
		10598540	45103	0	None	-134	3	Human	5.0	pKi	=	5.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	426	6	2	3	5.0	O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		CHEMBL146291	45103	0	None	-134	3	Human	5.0	pKi	=	5.0	Binding	Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cellsInhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells	ChEMBL	426	6	2	3	5.0	O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)C1CCCC1	10.1021/jm0003135
		44443722	161699	0	None	-29	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.06.081
		CHEMBL400953	161699	0	None	-29	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	ChEMBL	404	6	2	3	3.7	O=C(N[C@H]1[C@@H]2CN(Cc3ccccc3)C[C@@H]21)C(O)(c1ccccc1)C1CCCCC1	10.1016/j.bmcl.2007.06.081
		10360219	108787	0	None	1	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		CHEMBL301670	108787	0	None	1	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against human muscarine receptor (hM2) cloned in CHO cellsBinding affinity against human muscarine receptor (hM2) cloned in CHO cells	ChEMBL	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2C[C@@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@H]12	10.1016/s0960-894x(02)00315-3
		57326325	83959	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2042554	83959	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		CHEMBL2078987	83959	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]N-methylscopolamine from human muscarinic M2 receptor expressed in CHO cells after 120 mins by scintillation counting	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1021/jm2013216
		44593624	194908	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL498357	194908	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		CHEMBL554916	194908	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells	ChEMBL	362	3	0	2	3.8	C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1	10.1016/j.bmc.2008.04.013
		57326325	83959	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL2042554	83959	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL2078987	83959	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	297	4	0	3	2.9	CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		145960592	168140	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		CHEMBL4126071	168140	0	None	-2	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting methodDisplacement of [3H]NMS from recombinant human muscarinic M2 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method	ChEMBL	393	4	0	5	3.0	O=C(O[C@H]1CN2CCC1CC2)[C@H]1COCC(c2ccccc2)(c2ccccc2)O1	10.1016/j.ejmech.2017.06.004
		17621	67371	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	375	6	1	3	2.8	CCN(CC)CC#CCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
		CHEMBL176012	67371	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.Displacement of [3H]QNB (quinuclidinyl benzylate) from muscarinic M2 receptor of rat heart homogenates.	ChEMBL	375	6	1	3	2.8	CCN(CC)CC#CCN1C(=O)NC(c2ccccc2)(c2ccccc2)C1=O	10.1016/S0960-894X(97)00143-1
		3072504	12584	7	None	-	1	Mouse	5.0	pKi	=	5.0	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		CHEMBL107892	12584	7	None	-	1	Mouse	5.0	pKi	=	5.0	Binding	Ability to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortexAbility to displace [3H]methylscopolamine ([3H]NMS) from mouse cerebral cortex	ChEMBL	395	10	2	9	3.1	CN(C)Cc1ccc(CSCCNc2cc(N)c([N+](=O)[O-])cc2[N+](=O)[O-])o1	10.1021/jm00095a008
		71718668	93574	0	None	-1	2	Rat	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2321893	93574	0	None	-1	2	Rat	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	337	3	0	5	2.7	CC(=O)O[C@@H]1C[C@@H]2C[C@H](OC(=O)c3ccccc3Cl)C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		300	9288	15	None	1	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
		4141	9288	15	None	1	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
		CHEMBL92387	9288	15	None	1	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counterDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by liquid scintillation counter	ChEMBL	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	10.1021/jm800145d
		2904292	190359	13	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
		CHEMBL4800495	190359	13	None	-	1	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	306	2	0	3	4.3	CC1CCCCN1CC(=O)n1c2ccccc2c2ccccc21	10.1016/j.bmcl.2020.127632
		46227459	20907	0	None	-1	2	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL1198076	20907	0	None	-1	2	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		CHEMBL594802	20907	0	None	-1	2	Human	4.0	pKi	=	4.0	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cells by microplate scintillation counting	ChEMBL	188	2	0	2	0.9	CC1(C)CO[C@H](C[N+](C)(C)C)CO1	10.1016/j.bmc.2009.10.027
		16125681	91543	0	None	-141	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	481	5	1	2	5.6	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		CHEMBL223079	91543	0	None	-141	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	481	5	1	2	5.6	O=C1NC(c2ccc(F)cc2)(c2ccc(F)cc2)CN1C1CCN(Cc2cccc(Cl)c2)CC1	10.1021/jm061159a
		10243426	128694	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2csc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL359027	128694	0	None	-2	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	241	1	0	2	4.0	C1=C(c2csc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
		16125374	91507	0	None	-36	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	423	5	1	4	4.7	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		CHEMBL222860	91507	0	None	-36	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cellsDisplacement of [3H]N-methyl-scopolamine from human muscarinic M2 receptor expressed in CHO K1 cells	ChEMBL	423	5	1	4	4.7	O=C1NC(c2cccs2)(c2cccs2)CN1C1CCN(Cc2ccccc2)CC1	10.1021/jm061159a
		15050948	109594	0	None	1	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	513	7	3	7	1.8	NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		CHEMBL305403	109594	0	None	1	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M2 of rat heart tissue membrane.	ChEMBL	513	7	3	7	1.8	NCCNC(=O)c1ccc(CN2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1	10.1021/jm00111a032
		10451634	211229	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	367	10	0	4	4.1	CCN(CC)CCOCCOC(=O)C1(c2ccc(Cl)cc2)CCCC1	10.1021/jm00041a006
		CHEMBL72219	211229	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	ChEMBL	367	10	0	4	4.1	CCN(CC)CCOCCOC(=O)C1(c2ccc(Cl)cc2)CCCC1	10.1021/jm00041a006
		11808946	127414	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		CHEMBL354678	127414	0	None	2	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamineBinding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]N-methylscopolamine	ChEMBL	306	6	0	2	4.5	CCC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1021/jm020895l
		47358375	187541	1	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
		CHEMBL4756164	187541	1	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysisDisplacement of [3H]-NMS from muscarinic M2 receptor (unknown origin) expressed in CHO-K1 cell membranes assessed as inhibition constant by radioligand competition analysis	ChEMBL	272	4	1	2	2.9	O=C(CCN1CCCc2ccccc21)NC1CCCC1	10.1016/j.bmcl.2020.127632
		87934	104857	24	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		CHEMBL273308	104857	24	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		CHEMBL542883	104857	24	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Compound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptorCompound tested in vitro for displacement of [3H]quinuclidinyl benzilate from rat cerebellum membrane expressing muscarinic M2 receptor	ChEMBL	210	1	0	3	0.5	CCN1C(=O)CC2(CCN(C)CC2)C1=O	10.1021/jm00068a005
		21862266	148791	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	183	0	0	3	0.8	C[C@H]1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		CHEMBL38756	148791	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligandCompound was evaluated for its binding affinity against muscarinic acetylcholine receptor M2 in guinea pig heart using (-)-[3H]-QNB as radioligand	ChEMBL	183	0	0	3	0.8	C[C@H]1OCC2(CN3CCC2CC3)O1	10.1021/jm00087a007
		10468535	104905	1	None	-1	3	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	273	0	0	1	4.2	c1ccc2c(c1)C(=C1CN3CCC1CC3)c1ccccc1-2	10.1016/S0960-894X(01)80824-6
		CHEMBL273586	104905	1	None	-1	3	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards muscarinic receptor in heart (M2) was determinedIn vitro binding affinity towards muscarinic receptor in heart (M2) was determined	ChEMBL	273	0	0	1	4.2	c1ccc2c(c1)C(=C1CN3CCC1CC3)c1ccccc1-2	10.1016/S0960-894X(01)80824-6
		14964513	18191	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL1180268	18191	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		CHEMBL119508	18191	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	ChEMBL	209	2	0	1	0.6	C[C@@H]1CC(=O)N(CC#CC[N+](C)(C)C)C1	10.1021/jm00075a007
		289	7030	12	None	-89	14	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		9948320	7030	12	None	-89	14	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		CHEMBL1242950	7030	12	None	-89	14	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	ChEMBL	301	8	0	2	4.9	CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C	10.1021/jm100697g
		137628799	167772	0	None	7	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4064668	167772	0	None	7	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		CHEMBL4116150	167772	0	None	7	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting methodDisplacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liquid scintillation counting method	ChEMBL	212	4	0	1	2.1	COc1ccc(F)c(CC[N+](C)(C)C)c1	10.1021/acs.jmedchem.7b01113
		2166	9897	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		305	9897	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		5910	9897	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		CHEMBL550	9897	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		DB01085	9897	49	None	-4	8	Rat	5.0	pKi	=	5.0	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	ChEMBL	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	10.1016/0960-894X(95)00301-9
		71716836	93729	0	None	-11	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		CHEMBL2323442	93729	0	None	-11	3	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 minsDisplacement of [3H]NMS from muscarinic M2 receptor in Sprague-Dawley rat left atria after 60 mins	ChEMBL	348	4	0	7	1.9	CC(=O)O[C@H]1C[C@@H]2C[C@@H](OC(=O)c3ccccc3[N+](=O)[O-])C[C@@H]1N2C	10.1016/j.bmc.2012.12.052
		68617	212306	62	None	-32	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL1709	212306	62	None	-32	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		CHEMBL809	212306	62	None	-32	26	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
		462571	125573	1	None	-97	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	517	4	0	5	5.2	Cc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
		CHEMBL342137	125573	1	None	-97	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity towards muscarinic receptor M2Binding affinity towards muscarinic receptor M2	ChEMBL	517	4	0	5	5.2	Cc1nc(C)c(C(=O)N2CCC(C)(N3CCN([C@@H](C)c4ccc(C(F)(F)F)cc4)[C@@H](C)C3)CC2)c(C)n1	10.1016/s0960-894x(02)00918-6
		10466231	42849	0	None	-2	2	Human	7.0	pKi	=	7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2coc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL144385	42849	0	None	-2	2	Human	7.0	pKi	=	7	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	225	1	0	2	3.5	C1=C(c2coc3ccccc23)C2CCN1CC2	10.1021/jm00003a011
		10421689	42565	0	None	-2	2	Human	6.0	pKi	=	6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	239	1	0	1	1.8	C1=C(c2ccc[se]2)C2CCN1CC2	10.1021/jm00003a011
		CHEMBL144123	42565	0	None	-2	2	Human	6.0	pKi	=	6	Binding	Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heartBinding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]QNB from guinea pig heart	ChEMBL	239	1	0	1	1.8	C1=C(c2ccc[se]2)C2CCN1CC2	10.1021/jm00003a011
		1935	10506	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		2551	10506	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		6687	10506	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		CHEMBL95	10506	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		DB00382	10506	97	None	-	6	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamineBinding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		154059	10409	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		2457	10409	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		7483	10409	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		CHEMBL1734	10409	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		DB01591	10409	51	None	-12	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation countingDisplacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cells after 1 hr by scintillation counting	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		306	10229	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		3536	10229	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		53930639	10229	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		9577995	10229	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		CHEMBL134641	10229	21	None	-8	5	Human	8.2	pIC50	=	8.2	Binding	In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2	Drug Central	193	2	0	4	0.9	CO/N=C(/[C@H]1CN2CCC1CC2)\C#N	None
		2745	10633	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	10633	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	10633	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	10633	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	10633	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	10633	42	None	-46	9	Human	8.1	pIC50	=	8.1	Binding	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cellEvaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS binding using membranes from transfected chinese hamster ovarian cell	Drug Central	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		3652	10869	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	10869	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	10869	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	10869	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	10869	79	None	-	18	Rat	8.1	pIC50	=	8.1	Binding	In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MIn vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-M	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		2824	10765	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		345	10765	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		71203	10765	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		CHEMBL1892145	10765	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		DB13793	10765	0	None	-2	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	None
		92112	28477	18	None	1	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@@]12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)[C@H]32	None
		CHEMBL1318553	28477	18	None	1	4	Human	8.4	pKd	=	8.4	Binding	NoneNone	Drug Central	294	1	0	3	3.8	CC[C@@]12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)[C@H]32	None
		2360	10465	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		2484	10465	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		347	10465	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		441071	10465	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		CHEMBL227934	10465	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		DB15954	10465	43	None	1	5	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	None
		15376	10766	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		349	10766	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		3643	10766	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		CHEMBL1165342	10766	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		DB13374	10766	0	None	-1	4	Human	8.3	pKd	=	8.3	Binding	NoneNone	Drug Central	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	None
		21158560	119570	7	None	-1	4	Human	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
		CHEMBL3305985	119570	7	None	-1	4	Human	8.2	pKd	=	8.2	Binding	NoneNone	Drug Central	666	6	2	4	5.5	C=CC[N@@+]12CC[C@@]34c5ccccc5N5/C=C6/[C@H]7C[C@H]8[C@@]9(CC[N@@+]8(CC=C)C/C7=C/CO)c7ccccc7N(/C=C(/[C@@H](C[C@@H]31)/C(=C\CO)C2)[C@H]54)[C@@H]69	None
		2381	7450	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		374	7450	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		7128	7450	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		CHEMBL1101	7450	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		DB00810	7450	48	None	-15	9	Human	8.1	pKd	=	8.1	Binding	NoneNone	Drug Central	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		11968014	19530	5	None	-3	9	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
		CHEMBL1187846	19530	5	None	-3	9	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
		656598	19504	6	None	-2	4	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1187724	19504	6	None	-2	4	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL516476	19504	6	None	-2	4	Rat	8.1	pKd	=	8.1	Binding	In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineIn vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine	Drug Central	304	4	1	3	2.1	C[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		367	10596	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		5487427	10596	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		8592	10596	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		CHEMBL1900528	10596	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		CHEMBL3305968	10596	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		CHEMBL4650755	10596	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		DB01409	10596	12	None	-2	8	Human	10.3	pKd	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	23435542
		23056	6900	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
		23056	6900	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
		318	6900	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
		318	6900	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
		3260	6900	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
		3260	6900	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
		CHEMBL12980	6900	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	3443095
		CHEMBL12980	6900	29	None	-1	8	Human	10.4	pKd	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	7562472
		11536903	9176	68	None	-6	2	Human	4.4	pKd	=	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
		3262	9176	68	None	-6	2	Human	4.4	pKd	=	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
		CHEMBL3770346	9176	68	None	-6	2	Human	4.4	pKd	=	4.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	3	2	5	2.7	COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	21989256
		57664406	9177	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
		57664406	9177	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
		6938	9177	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
		6938	9177	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
		CHEMBL4089376	9177	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24256733
		CHEMBL4089376	9177	50	None	-1	2	Human	5.6	pKd	=	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	5	2	7	1.9	CN1CCN(CC1)C(=O)COc1nc2sc(c(c2c(c1Cl)C)N)C(=O)NC1CC1	24807965
		1273	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		1273	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		3450	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		3450	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		356	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		356	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		6172	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		6172	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		67425	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		67425	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		CHEMBL360055	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		CHEMBL360055	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		DB00483	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	7651370
		DB00483	8535	16	None	-1	3	Human	6.1	pKd	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	990587
		341	7128	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	12815174
		341	7128	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	17591774
		341	7128	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	9224827
		5311001	7128	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	12815174
		5311001	7128	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	17591774
		5311001	7128	0	None	5	4	Human	6.5	pKd	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	666	6	2	4	5.5	C=CC[N+]12CC[C@@]34[C@@H]2C[C@@H](C(=CCO)C1)C1=CN2c5ccccc5[C@]56[C@@H]2C(=CN([C@H]31)c1c4cccc1)[C@H]1C[C@@H]6[N+](CC1=CCO)(CC5)CC=C	9224827
		167962	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		167962	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
		362	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		362	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
		CHEMBL31599	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		CHEMBL31599	10841	4	None	-	1	Human	6.8	pKd	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	15163212
		168057	7995	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
		168057	7995	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
		7634	7995	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
		7634	7995	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
		CHEMBL28407	7995	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	17591774
		CHEMBL28407	7995	11	None	-	1	Human	7.1	pKd	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	562	16	0	4	4.5	O=C1N(CCC[N+](CCCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	9890565
		2381	7450	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		374	7450	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		7128	7450	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		CHEMBL1101	7450	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		DB00810	7450	48	None	-15	9	Human	8.2	pKd	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	1346637
		10350027	8210	0	None	-	1	Human	8.5	pKd	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		364	8210	0	None	-	1	Human	8.5	pKd	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		365	8210	0	None	-	1	Human	8.5	pKd	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		303	9752	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
		4629	9752	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
		8595	9752	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
		CHEMBL44674	9752	17	None	-1	6	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	6478115
		187	7043	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		294	7043	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		65	7043	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		8593	7043	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		CHEMBL667	7043	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		DB03128	7043	39	None	6	9	Human	8.8	pKd	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	14722259
		119357	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
		119357	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
		119357	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
		3264	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
		3264	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
		3264	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
		368	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
		368	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
		368	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
		CHEMBL279453	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1941609
		CHEMBL279453	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	29515448
		CHEMBL279453	7092	49	None	1	6	Human	9.0	pKd	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	32079174
		316	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		316	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		316	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		316	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		316	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		316	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		316	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		317	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		317	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		317	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		317	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		317	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		317	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		317	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		71183	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		71183	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		71183	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		71183	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		71183	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		71183	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		71183	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		CHEMBL3140030	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		CHEMBL3140030	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		CHEMBL3140030	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		CHEMBL3140030	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		CHEMBL3140030	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		CHEMBL3140030	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		CHEMBL3140030	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		CHEMBL376897	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		CHEMBL376897	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		CHEMBL376897	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		CHEMBL376897	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		CHEMBL376897	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		CHEMBL376897	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		CHEMBL376897	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		DB00462	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	11303071
		DB00462	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16369696
		DB00462	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	16675658
		DB00462	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7562472
		DB00462	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7651370
		DB00462	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	7687290
		DB00462	9611	19	None	-6	9	Human	9.6	pKd	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	9846649
		21123938	7520	0	None	-1	5	Human	3.5	pKd	None	3.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-]	9495826
		343	7520	0	None	-1	5	Human	3.5	pKd	None	3.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-]	9495826
		348	10575	0	None	-3	4	Human	3.9	pKd	None	3.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	2	1	6	1.9	OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C	14722259
		66706	10575	0	None	-3	4	Human	3.9	pKd	None	3.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	2	1	6	1.9	OCCc1sc2=Nc3c(Cn2c1C)cnc(n3)C	14722259
		2824	10765	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		345	10765	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		71203	10765	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		CHEMBL1892145	10765	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		DB13793	10765	0	None	-2	4	Human	4.2	pKd	None	4.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	294	1	0	3	3.8	CC[C@]12CCCN3[C@@H]2c2n(C(=O)C1)c1c(c2CC3)cccc1	9224827
		342	7519	55	None	-9	5	Human	4.3	pKd	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		442021	7519	55	None	-9	5	Human	4.3	pKd	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		CHEMBL501756	7519	55	None	-9	5	Human	4.3	pKd	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		342	7519	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
		342	7519	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		442021	7519	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
		442021	7519	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		CHEMBL501756	7519	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9224827
		CHEMBL501756	7519	55	None	-9	5	Human	4.5	pKd	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	2	0	5	2.1	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2	9495826
		344	9525	0	None	1	5	Human	4.6	pKd	None	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
		44358908	9525	0	None	1	5	Human	4.6	pKd	None	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
		CHEMBL139677	9525	0	None	1	5	Human	4.6	pKd	None	4.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	443	3	0	4	2.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl	9495826
		332	8815	0	None	1	5	Human	4.8	pKd	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
		44358893	8815	0	None	1	5	Human	4.8	pKd	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
		CHEMBL343796	8815	0	None	1	5	Human	4.8	pKd	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	485	4	0	4	3.8	COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1	9495826
		2360	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		2360	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		2360	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		2484	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		2484	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		2484	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		347	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		347	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		347	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		441071	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		441071	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		441071	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		CHEMBL227934	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		CHEMBL227934	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		CHEMBL227934	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		DB15954	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	12815174
		DB15954	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	7651370
		DB15954	10465	43	None	1	5	Human	5.0	pKd	None	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	0	0	3	2.1	O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3	9224827
		335	8617	0	None	-6	4	Human	5.0	pKd	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
		3500	8617	0	None	-6	4	Human	5.0	pKd	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
		CHEMBL157822	8617	0	None	-6	4	Human	5.0	pKd	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	5	2	7	3.3	COc1ccc2c(c1)c1c3c(=O)[nH]c(=O)c3c3c(c1n2CC(CN(C)C)O)n(C)c1c3cccc1	10860942
		346	10461	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
		44259	10461	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
		CHEMBL388978	10461	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
		DB02010	10461	0	None	-6	3	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	2	2	6	4.4	CN[C@@H]1C[C@H]2O[C@]([C@@H]1OC)(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O	10860942
		15376	10766	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		349	10766	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		3643	10766	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		CHEMBL1165342	10766	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		DB13374	10766	0	None	-1	4	Human	5.1	pKd	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	2	1	5	3.0	COC(=O)[C@@]1(O)C[C@]2(CC)CCCN3[C@@H]2c2n1c1ccccc1c2CC3	9224827
		15118529	10855	0	None	-3	4	Human	5.3	pKd	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
		340	10855	0	None	-3	4	Human	5.3	pKd	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
		CHEMBL1256845	10855	0	None	-3	4	Human	5.3	pKd	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	0	1	4	5.4	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=Cc3c(C[C@]12C)cn1c(n3)nc2c1cccc2	12435818
		108152	8982	0	None	-1	2	Human	5.7	pKd	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	495	2	0	7	4.7	COC(=O)[C@@]1(OC)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN(C1=O)C	10860942
		338	8982	0	None	-1	2	Human	5.7	pKd	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	495	2	0	7	4.7	COC(=O)[C@@]1(OC)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN(C1=O)C	10860942
		339	10853	0	None	-1	4	Human	5.9	pKd	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
		9803245	10853	0	None	-1	4	Human	5.9	pKd	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
		CHEMBL2206331	10853	0	None	-1	4	Human	5.9	pKd	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	0	1	4	5.2	C#C[C@]1(O)CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)Cc1cn3c(nc1C2)nc1c3cccc1	12435818
		2784	7739	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		351	7739	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		366	7739	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		676	7739	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		CHEMBL620	7739	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		DB00771	7739	13	None	-1	3	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		316	9611	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		317	9611	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		71183	9611	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		CHEMBL3140030	9611	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		CHEMBL376897	9611	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		DB00462	9611	19	None	-3	9	Rat	9.5	pKd	None	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	2846274
		2784	7739	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		351	7739	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		366	7739	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		676	7739	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		CHEMBL620	7739	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		DB00771	7739	13	None	1	3	Human	9.6	pKd	None	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1C[N+]2(C)CCC1CC2	9454790
		23056	6900	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		318	6900	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		3260	6900	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		CHEMBL12980	6900	29	3H-QNB	-1	8	Human	10.5	pKi	=	10.5	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		23056	6900	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		318	6900	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		3260	6900	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		CHEMBL12980	6900	29	3H-QNB	-1	8	Human	10.6	pKi	=	10.6	Binding	NoneNone	PDSP KiDatabase	337	4	1	4	2.6	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2	None
		44431393	94799	0	UNDEFINED	1	3	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	None
		CHEMBL234440	94799	0	UNDEFINED	1	3	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	402	6	1	5	3.5	CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1	None
		1427	8794	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	8794	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	8794	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	8794	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	8794	54	3H-MQNB(-)	1	27	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		132947	10636	9	3H-NMS	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
		361	10636	9	3H-NMS	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
		CHEMBL265256	10636	9	3H-NMS	1	9	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	None
		325	8843	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		3746	8843	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		657308	8843	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		CHEMBL1615433	8843	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		DB00332	8843	0	3H-NMS	-1	9	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		187	7043	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	7043	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	7043	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	7043	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	7043	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	7043	39	3H-NMS	6	9	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		131632304	222816	0	3H-QNB	-6	13	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
		12057539	214820	42	3H-MQNB(-)	-2	21	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-MQNB(-)	-2	21	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-MQNB(-)	-2	21	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		44431384	155639	0	UNDEFINED	2	3	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	None
		CHEMBL394137	155639	0	UNDEFINED	2	3	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	384	6	1	4	4.0	CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1	None
		12057539	214820	42	3H-PIRENZEPINE	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-PIRENZEPINE	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-PIRENZEPINE	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-MQNB(-)	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-MQNB(-)	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-MQNB(-)	-2	21	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-NMS	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-NMSP	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-QNB	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-NMS	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-NMSP	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-QNB	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-NMS	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-NMSP	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-QNB	-2	21	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-NMS	-2	21	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-NMS	-2	21	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-NMS	-2	21	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-MQNB(-)	-2	21	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-MQNB(-)	-2	21	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-MQNB(-)	-2	21	Rat	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-Arachidonic Acid	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-NMS	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-Arachidonic Acid	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-NMS	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-Arachidonic Acid	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-NMS	-2	21	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		24835791	222883	0	3H-MQNB(-)	1	2	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		5831	222742	0	3H-QNB	-29	12	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		42470	222962	0	3H-NMS	-3	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	345	10	0	3	4.9	CCN(CCCC(=O)C1CCCCC1)C(C)CC2=CC=C(C=C2)OC	None
		3246155	222741	0	3H-QNB	-6	17	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		131632304	222816	0	3H-NMS	-10	13	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
		325	8843	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		3746	8843	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		657308	8843	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		CHEMBL1615433	8843	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		DB00332	8843	0	3H-NMS	-3	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	None
		12057539	214820	42	3H-NMS	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-QNB	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	3H-MQNB(-)	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-NMS	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-QNB	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-MQNB(-)	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-NMS	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-QNB	-2	21	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-MQNB(-)	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		24835791	222883	0	3H-MQNB(-)	-1	2	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		12057539	214820	42	3H-QNB	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-QNB	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-QNB	-2	21	Rat	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		16721019	94761	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	None
		CHEMBL234258	94761	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	7	2	5	2.5	CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1	None
		44431389	152929	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	None
		CHEMBL391977	152929	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	348	6	2	5	2.3	CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1	None
		1734	6904	10	3H-PIRENZEPINE	-12	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	6904	10	3H-PIRENZEPINE	-12	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	6904	10	3H-PIRENZEPINE	-12	13	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		135398737	7745	93	3H-NMS	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	7745	93	3H-QNB	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-NMS	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-QNB	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-NMS	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-QNB	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-NMS	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-QNB	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-NMS	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-QNB	-6	90	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		154825138	222817	0	3H-4-DAMP	-1	12	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154825138	222817	0	3H-NMS	-1	12	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		11434515	7049	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		11519741	7049	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		4484	7049	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		7449	7049	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		CHEMBL1194325	7049	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		DB08897	7049	6	None	-6	5	Human	8.0	pKi	=	8	Binding	Binding affinity to muscarinic M2 receptorBinding affinity to muscarinic M2 receptor	Drug Central	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	None
		154825138	222817	0	3H-MQNB(-)	-1	12	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		2381	7450	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		374	7450	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		7128	7450	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		CHEMBL1101	7450	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		DB00810	7450	48	3H-NMS	-19	9	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		71202	223151	0	3H-NMS	-3	5	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	340	3	0	3	4.9	CC1(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)SCCN(C)C)C	None
		202	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	8290	77	UNDEFINED	-9	33	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		5656	209845	87	UNDEFINED	-25	43	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	209845	87	UNDEFINED	-25	43	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		54841	209906	52	UNDEFINED	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	209906	52	UNDEFINED	-1	30	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		11957621	222818	0	3H-NMS	-12	10	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	203	3	2	3	1.3	COC1=C(C=CC(=C1)CCN)O.Cl	None
		11957621	222818	0	3H-NMS	-12	10	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	203	3	2	3	1.3	COC1=C(C=CC(=C1)CCN)O.Cl	None
		3075702	224111	0	3H-AF-DX384	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
		145	6928	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		1832	6928	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		CHEMBL7257	6928	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		DB14010	6928	49	3H-QNB	-1949	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
		179	7188	115	3H-QNB	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	7188	115	3H-QNB	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	7188	115	3H-QNB	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	7188	115	3H-QNB	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	7188	115	3H-QNB	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		141	8209	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		6089	8209	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		CHEMBL12420	8209	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		DB01488	8209	35	3H-QNB	-114	22	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
		119376	8622	48	3H-NMS	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		247	8622	48	3H-NMS	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		CHEMBL33884	8622	48	3H-NMS	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		1353	8692	93	3H-QNB	-5011	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-QNB	-5011	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-QNB	-5011	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-QNB	-5011	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-QNB	-5011	85	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1588	9105	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	3H-QNB	-28840	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		290	9251	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		4022	9251	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		5926	9251	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		CHEMBL40554	9251	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		CHEMBL74300	9251	6	3H-MQNB(-)	-12	7	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	None
		15897	9637	0	3H-QNB	-204	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-QNB	-204	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-QNB	-204	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		2166	9897	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		305	9897	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		5910	9897	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		CHEMBL550	9897	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		DB01085	9897	49	3H-MQNB(-)	-4	8	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		2200	9905	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-NMS	-35	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		119570	9933	96	3H-QNB	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	3H-QNB	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	3H-QNB	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	3H-QNB	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	3H-QNB	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2389	10104	118	3H-QNB	-2818	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-QNB	-2818	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-QNB	-2818	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-QNB	-2818	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-QNB	-2818	66	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		128563	10237	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		1666	10237	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		CHEMBL445332	10237	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		DB12327	10237	33	3H-QNB	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		6917970	10463	61	3H-QNB	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	10463	61	3H-QNB	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	10463	61	3H-QNB	-2290	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		1267	10576	49	3H-NMS	-4168	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-NMS	-4168	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-NMS	-4168	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		213	10625	55	3H-QNB	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	10625	55	3H-QNB	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	10625	55	3H-QNB	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	10625	55	3H-QNB	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	10625	55	3H-QNB	-912	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		185	10778	60	3H-QNB	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	10778	60	3H-QNB	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	10778	60	3H-QNB	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	10778	60	3H-QNB	-30902	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		2865	10915	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-QNB	-1659	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		103	10925	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-QNB	-177	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2662	18156	131	3H-QNB	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	18156	131	3H-QNB	-41	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		5090	22333	106	3H-QNB	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	22333	106	3H-QNB	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		10297	33885	30	3H-QNB	-38	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	33885	30	3H-QNB	-38	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		156391	53574	99	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	53574	99	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	53574	99	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		115237	62359	119	3H-QNB	-42657	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-QNB	-42657	54	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		10624	77075	19	3H-QNB	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	77075	19	3H-QNB	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	77075	19	3H-QNB	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		1979	84101	70	3H-cAMP	-14	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		CHEMBL20835	84101	70	3H-cAMP	-14	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		2244	101008	100	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	101008	100	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		3025067	106158	64	3H-NMS	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		65853	106158	64	3H-NMS	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		CHEMBL282614	106158	64	3H-NMS	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		3663	106743	83	3H-QNB	-288	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		CHEMBL286494	106743	83	3H-QNB	-288	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		37632	118369	28	3H-QNB	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
		CHEMBL328250	118369	28	3H-QNB	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	0	5	3.3	CN(C)Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	None
		3452843	126303	15	3H-NMS	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		CHEMBL345686	126303	15	3H-NMS	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		446220	140299	14	3H-QNB	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	140299	14	3H-QNB	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		44208932	147485	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		CHEMBL381689	147485	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		1615	174570	24	3H-QNB	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	174570	24	3H-QNB	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		5280343	195054	124	3H-QNB	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL1520590	195054	124	3H-QNB	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL50	195054	124	3H-QNB	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		3672	199312	136	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	199312	136	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		54676228	200394	112	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		CHEMBL527	200394	112	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		4495	203314	92	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	203314	92	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		54677470	207330	115	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	207330	115	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	207330	115	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		162265	209053	22	3H-QNB	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	209053	22	3H-QNB	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	209053	22	3H-QNB	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		5281600	209804	92	3H-QNB	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	209804	92	3H-QNB	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	209845	87	3H-QNB	-25	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	209845	87	3H-QNB	-25	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		1973	210262	15	3H-AF-DX384	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL1394464	210262	15	3H-AF-DX384	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL66089	210262	15	3H-AF-DX384	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		202478	211466	20	3H-QNB	-52	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
		CHEMBL7393	211466	20	3H-QNB	-52	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
		5311189	211620	11	3H-QNB	-112	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
		CHEMBL7549	211620	11	3H-QNB	-112	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
		4158	212120	21	3H-QNB	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	212120	21	3H-QNB	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	212120	21	3H-QNB	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		4054	212280	72	3H-QNB	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	212280	72	3H-QNB	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	212280	72	3H-QNB	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		119607	212982	113	3H-QNB	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	212982	113	3H-QNB	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		3337	213146	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-QNB	-120	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		444	213445	53	3H-QNB	-2089	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		CHEMBL894	213445	53	3H-QNB	-2089	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		16231	214288	57	3H-NMS	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		CHEMBL945	214288	57	3H-NMS	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		5831	222742	0	3H-NMS	-29	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		11954259	222758	0	3H-QNB	-15135	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		104911	222798	0	3H-QNB	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		None	222806	0	3H-NMS	-6309	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	453	9	2	6	2.6	COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl	None
		24835791	222883	0	3H-MQNB(-)	-1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		None	222914	0	3H-QNB	-10471	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		40589	222923	0	3H-QNB	-407	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	377	7	0	6	2.5	CCC1=NN(C(=O)N1CC)CCCN2CCN(CC2)C3=CC(=CC=C3)Cl	None
		25137849	222958	0	3H-QNB	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	222958	0	3H-QNB	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		None	223018	0	3H-QNB	-95499	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		None	223090	0	3H-QNB	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	223091	0	3H-QNB	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	223092	0	3H-QNB	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	223093	0	3H-QNB	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	223094	0	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	223095	0	3H-QNB	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	223096	0	3H-QNB	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	223097	0	3H-QNB	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
		None	223104	0	3H-QNB	-13	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		1576	223105	0	3H-QNB	-16	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		None	223106	0	3H-QNB	-16	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
		4978	223107	0	3H-QNB	-7	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
		None	223108	0	3H-QNB	-3	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		None	223109	0	3H-QNB	-281	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		None	223110	0	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
		135269	223168	0	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	223169	0	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		5018304	223170	0	3H-QNB	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	223171	0	3H-QNB	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		119828	223173	0	3H-QNB	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	223174	0	3H-QNB	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	223268	0	3H-QNB	-4570	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		None	223272	0	3H-NMS	-10471285	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	372	2	1	3	4.4	CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl	None
		None	223273	0	3H-NMS	-1	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	399	7	4	5	1.8	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O	None
		20980871	223209	0	3H-QNB	-27	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	295	3	0	2	4.7	CN(C)CCC=C1C2=CC=CC=C2CSC3=CC=CC=C31	None
		367	10596	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		5487427	10596	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		8592	10596	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL1900528	10596	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL3305968	10596	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL4650755	10596	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		DB01409	10596	12	None	-2	8	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		9399	222885	0	3H-MQNB(-)	-	1	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	493	3	2	4	-1.1	C[N+]1(CCOC(C1)(C2=CC=C(C=C2)C3=CC=C(C=C3)C4(C[N+](CCO4)(C)C)O)O)C.[Br-]	None
		180	7189	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	7189	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	7189	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	7189	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	7189	56	3H-QNB	-27	40	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1971	9641	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	9641	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	9641	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	9641	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	9641	38	3H-QNB	-9	30	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		44431388	94094	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	None
		CHEMBL233202	94094	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	348	6	1	5	2.8	CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1	None
		44431380	94760	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	None
		CHEMBL234257	94760	0	UNDEFINED	-2	3	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	318	5	1	4	2.9	CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1	None
		154825138	222817	0	3H-MQNB(-)	-1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154825138	222817	0	3H-NMS	-1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154825138	222817	0	3H-NMS	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154734599	9281	12	3H-4-DAMP	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		154734599	9281	12	3H-PIRENZEPINE	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-4-DAMP	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-PIRENZEPINE	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-4-DAMP	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-PIRENZEPINE	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-4-DAMP	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-PIRENZEPINE	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		1224	8214	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	8214	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	8214	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	8214	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	8214	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	8214	83	3H-QNB	-6	13	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		310	8703	0	3H-NMS	-25	11	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		3602	8703	0	3H-NMS	-25	11	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		CHEMBL3545990	8703	0	3H-NMS	-25	11	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		1353	8692	93	3H-NMS	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	3H-QNB	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-NMS	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-QNB	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-NMS	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-QNB	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-NMS	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-QNB	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-NMS	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-QNB	-338	85	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3652	10869	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	10869	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	10869	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	10869	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	10869	79	3H-QNB	-18	18	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		None	223036	0	3H-4-DAMP	-8	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	851	24	12	12	-2.6	CCC(C)C(C(=O)NC(CC(=O)O)C(=O)O)NC(=O)C(CO)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4	None
		1734	6904	10	3H-NMS	-12	13	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	6904	10	3H-NMS	-12	13	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	6904	10	3H-NMS	-12	13	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		154734599	9281	12	3H-NMS	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-NMS	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-NMS	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-NMS	1	12	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		2745	10633	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	10633	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	10633	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	10633	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	10633	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	10633	42	3H-NMS	-18	9	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		None	223036	0	3H-NMS	-8	5	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	851	24	12	12	-2.6	CCC(C)C(C(=O)NC(CC(=O)O)C(=O)O)NC(=O)C(CO)NC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C4CCCN4	None
		2337	10030	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-QNB	-31	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135398737	7745	93	3H-QNB	-22	90	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-QNB	-22	90	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-QNB	-22	90	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-QNB	-22	90	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-QNB	-22	90	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	10577	58	3H-QNB	-19	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-QNB	-19	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-QNB	-19	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-QNB	-19	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-QNB	-19	54	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		4066	211405	78	3H-QNB	-1	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		CHEMBL73451	211405	78	3H-QNB	-1	7	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		154825138	222817	0	3H-MQNB(-)	-1	12	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		154734599	9281	12	3H-NMS	1	12	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-NMS	1	12	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-NMS	1	12	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-NMS	1	12	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		103	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		103	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-QNB	-177	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		4601	213526	35	3H-NMS	-6	17	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	213526	35	3H-NMS	-6	17	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	213526	35	3H-NMS	-6	17	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		4839	223154	0	3H-NMS	-3	5	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	323	5	0	3	3.8	CCN1CCCC(C1)OC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	None
		2274	9947	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	9947	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	9947	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	9947	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	9947	58	3H-QNB	-100	31	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		1712	9270	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	9270	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	9270	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	9270	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	9270	43	3H-QNB	-5	22	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		154825138	222817	0	3H-NMS	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		2270	9945	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		4811	9945	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		4913	9945	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		CHEMBL640	9945	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		DB01035	9945	69	3H-MQNB(-)	-	1	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		2726	7706	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-QNB	-79	72	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		3012003	222924	0	3H-QNB	-1	12	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
		308	8841	23	3H-MQNB(-)	-11	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		3603	8841	23	3H-MQNB(-)	-11	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		CHEMBL1256682	8841	23	3H-MQNB(-)	-11	9	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		154734599	9281	12	3H-QNB	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-QNB	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-QNB	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-QNB	-1	12	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		5387	101654	31	3H-NMS	-19	6	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	None
		CHEMBL253978	101654	31	3H-NMS	-19	6	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	2	1	5	2.5	Cc1scc2c1N(C(=O)CN1CCN(C)CC1)c1ccccc1NC2=O	None
		1225	8253	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	8253	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	8253	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	8253	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	8253	26	3H-QNB	-117	22	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		73707487	223153	0	3H-NMS	-23	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	355	3	1	4	2.5	CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br	None
		1273	8535	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		3450	8535	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		356	8535	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		6172	8535	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		67425	8535	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		CHEMBL360055	8535	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		DB00483	8535	16	3H-MQNB(-)	-1	3	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		308	8841	23	3H-MQNB(-)	-10	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		3603	8841	23	3H-MQNB(-)	-10	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		CHEMBL1256682	8841	23	3H-MQNB(-)	-10	9	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		277	8083	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-QNB	-12	50	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		135398745	9688	112	3H-NMS	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	9688	112	3H-QNB	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-NMS	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-QNB	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-NMS	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-QNB	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-NMS	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-QNB	-9	65	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		101	10594	24	3H-QNB	-741	14	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
		55752	10594	24	3H-QNB	-741	14	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL35057	10594	24	3H-QNB	-741	14	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	6	0	6	3.9	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1nsc2c1cccc2	None
		2448	106099	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	106099	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		2448	106099	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	106099	70	3H-QNB	-72	18	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		5831	222742	0	3H-MQNB(-)	-29	12	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		3337	213146	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-QNB	-120	40	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		154734599	9281	12	3H-NMS	-1	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-NMS	-1	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-NMS	-1	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-NMS	-1	12	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		None	223033	0	3H-NMS	-1659	20	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		2200	9905	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-4-DAMP	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		44431383	94797	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	None
		CHEMBL234439	94797	0	UNDEFINED	1	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	346	6	1	4	3.7	CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1	None
		131632304	222816	0	3H-QNB	-6	13	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
		2230	7253	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		296	7253	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		CHEMBL7303	7253	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		DB04365	7253	60	3H-QNB	-75	10	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		44431381	155800	0	UNDEFINED	1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	None
		CHEMBL394254	155800	0	UNDEFINED	1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	318	6	1	4	2.9	CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1	None
		None	223035	0	3H-NMS	-5	5	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	311	3	1	2	3.9	C1CCC(CC1)C(C#CCN2CCCCC2)(C3=CC=CC=C3)O	None
		124226	8702	0	3H-NMS	-19	5	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		322	8702	0	3H-NMS	-19	5	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		5831	222742	0	3H-MQNB(-)	-190	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		135398737	7745	93	3H-NMS	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	7745	93	3H-NMSP	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-NMS	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-NMSP	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-NMS	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-NMSP	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-NMS	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-NMSP	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-NMS	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-NMSP	-22	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		5831	222742	0	3H-MQNB(-)	-190	12	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		68617	212306	62	3H-QNB	-32	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	212306	62	3H-QNB	-32	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	212306	62	3H-QNB	-32	26	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		11954259	222758	0	3H-QNB	-15135	43	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		4601	213526	35	3H-QNB	-2	17	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	213526	35	3H-QNB	-2	17	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	213526	35	3H-QNB	-2	17	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		2726	7706	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-MQNB(-)	-79	72	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1212	8443	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-QNB	-1380	65	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		214	10632	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	10632	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	10632	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	10632	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	10632	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	10632	58	3H-QNB	-2630	30	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2200	9905	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-QNB	-31	13	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		2200	9905	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-NMS	-35	13	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1979	84101	70	3H-cAMP	-2	4	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		CHEMBL20835	84101	70	3H-cAMP	-2	4	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		302	9751	25	3H-MQNB(-)	-34	8	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		4630	9751	25	3H-MQNB(-)	-34	8	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		CHEMBL7634	9751	25	3H-MQNB(-)	-34	8	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		15387	52596	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	52596	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		15387	52596	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	52596	55	3H-QNB	-16	24	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		3042	8196	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		355	8196	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		868	8196	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		CHEMBL1123	8196	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		DB00804	8196	35	3H-NMS	-28	15	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		5831	222742	0	3H-cAMP	-190	12	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		310	8703	0	3H-NMS	-56	11	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		3602	8703	0	3H-NMS	-56	11	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		CHEMBL3545990	8703	0	3H-NMS	-56	11	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		10921	19817	23	3H-MQNB(-)	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		2968	19817	23	3H-MQNB(-)	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		CHEMBL1190	19817	23	3H-MQNB(-)	-	1	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		4919	213013	23	3H-QNB	-3	9	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		CHEMBL86715	213013	23	3H-QNB	-3	9	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		2865	10915	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-QNB	-1659	53	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		100	10577	58	3H-QNB	-19	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-QNB	-19	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-QNB	-19	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-QNB	-19	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-QNB	-19	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1273	8535	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		3450	8535	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		356	8535	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		6172	8535	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		67425	8535	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		CHEMBL360055	8535	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		DB00483	8535	16	3H-MQNB(-)	-1	3	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		2905	21270	50	3H-NMS	-16	5	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	None
		CHEMBL1201338	21270	50	3H-NMS	-16	5	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	291	6	1	4	2.2	CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1	None
		2200	9905	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-QNB	-35	13	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1209	8439	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	8439	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	8439	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	8439	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	8439	75	3H-QNB	-22	32	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		2726	7706	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-QNB	-79	72	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		11976	7707	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	7707	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	7707	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	7707	59	3H-QNB	-23	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		209	9831	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	9831	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	9831	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	9831	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	9831	97	3H-QNB	-4073	23	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		302	9751	25	3H-MQNB(-)	-4	8	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		4630	9751	25	3H-MQNB(-)	-4	8	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		CHEMBL7634	9751	25	3H-MQNB(-)	-4	8	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		1192	6935	47	3H-NMS	-46	17	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		1794	6935	47	3H-NMS	-46	17	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		CHEMBL501701	6935	47	3H-NMS	-46	17	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		2028	9753	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		359	9753	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		4634	9753	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		CHEMBL1231	9753	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		DB01062	9753	80	3H-NMS	-5	11	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		154734599	9281	12	3H-NMS	1	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-NMS	1	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-NMS	1	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-NMS	1	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		1734	6904	10	3H-QNB	-12	13	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	6904	10	3H-QNB	-12	13	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	6904	10	3H-QNB	-12	13	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		1734	6904	10	3H-NMS	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	6904	10	3H-NMS	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	6904	10	3H-NMS	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		3246155	222741	0	3H-NMS	-16	17	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		1734	6904	10	3H-4-DAMP	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	6904	10	3H-4-DAMP	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	6904	10	3H-4-DAMP	-9	13	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		308	8841	23	3H-NMS	-10	9	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		3603	8841	23	3H-NMS	-10	9	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		CHEMBL1256682	8841	23	3H-NMS	-10	9	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	None
		1613	9127	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	3H-QNB	-42	44	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		2865	10915	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-QNB	-1659	53	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		3042	8196	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		355	8196	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		868	8196	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		CHEMBL1123	8196	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		DB00804	8196	35	3H-NMS	-12	15	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		7534	223152	0	3H-NMS	-3	5	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	291	3	1	4	2.5	CC1CC(CC(N1C)(C)C)OC(=O)C(C2=CC=CC=C2)O	None
		3947	213174	53	3H-QNB	-6	16	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		CHEMBL87708	213174	53	3H-QNB	-6	16	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		114743	222880	0	3H-QNB	-1	8	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	291	1	1	1	4.9	C1CC(C2=CC=CC=C2C1C3=CC(=C(C=C3)Cl)Cl)N	None
		2200	9905	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-NMS	-31	13	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		5831	222742	0	3H-cAMP	-29	12	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		3294	8787	111	3H-NMS	-194	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	3H-NMS	-194	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	3H-NMS	-194	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	3H-NMS	-194	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	3H-NMS	-194	44	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		15897	9637	0	3H-QNB	-204	36	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-QNB	-204	36	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-QNB	-204	36	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		187	7043	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	7043	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	7043	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	7043	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	7043	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	7043	39	3H-NMS	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		43815	193699	64	3H-QNB	-15	25	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	193699	64	3H-QNB	-15	25	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	193699	64	3H-QNB	-15	25	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		187	7043	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	7043	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	7043	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	7043	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	7043	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	7043	39	3H-MQNB(-)	6	9	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		130169	10377	0	3H-NMS	-26	5	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	None
		331	10377	0	3H-NMS	-26	5	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	None
		242	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-QNB	-295	51	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2389	10104	118	3H-QNB	-2818	66	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-QNB	-2818	66	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-QNB	-2818	66	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-QNB	-2818	66	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-QNB	-2818	66	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2200	9905	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-MQNB(-)	-35	13	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		3337	213146	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-QNB	-120	40	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		442108	91411	6	3H-QNB	-3	12	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		CHEMBL222287	91411	6	3H-QNB	-3	12	Human	4.4	pKi	=	4.4	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		2370	7410	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		297	7410	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		358	7410	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		CHEMBL1482	7410	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		DB01019	7410	31	None	-1	5	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	None
		5831	222742	0	3H-NMS	-29	12	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		129989	7239	51	3H-NMS	-1	9	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
		8584	7239	51	3H-NMS	-1	9	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
		CHEMBL43383	7239	51	3H-NMS	-1	9	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	None
		10938	8483	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
		299	8483	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
		3256	8483	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
		CHEMBL2110739	8483	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	None
		154734599	9281	12	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		154825138	222817	0	3H-NMS	-1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		1734	6904	10	3H-MQNB(-)	-9	13	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	6904	10	3H-MQNB(-)	-9	13	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	6904	10	3H-MQNB(-)	-9	13	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		71128	103585	25	3H-NMS	-3	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	None
		CHEMBL26505	103585	25	3H-NMS	-3	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	325	8	0	3	3.9	CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1	None
		44431376	94092	0	UNDEFINED	-2	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	None
		CHEMBL233200	94092	0	UNDEFINED	-2	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	344	6	1	4	2.7	CN(C)C1(CNCCc2ccccc2F)COc2ccccc2OC1	None
		135409468	8816	69	3H-QNB	-114	39	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	8816	69	3H-QNB	-114	39	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	8816	69	3H-QNB	-114	39	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		2200	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		62865	8057	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	8057	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	8057	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	8057	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	8057	0	3H-Methoctramine	-6	15	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		154734599	9281	12	3H-MQNB(-)	1	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-MQNB(-)	1	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-MQNB(-)	1	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-MQNB(-)	1	12	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4919	213013	23	3H-NMS	-9	9	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		CHEMBL86715	213013	23	3H-NMS	-9	9	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		187	7043	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	7043	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	7043	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	7043	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	7043	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	7043	39	3H-MQNB(-)	-6	9	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		2726	7706	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-QNB	-79	72	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1979	84101	70	3H-cAMP	-14	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		CHEMBL20835	84101	70	3H-cAMP	-14	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		154734599	9281	12	3H-MQNB(-)	-1	12	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-MQNB(-)	-1	12	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-MQNB(-)	-1	12	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-MQNB(-)	-1	12	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		44431372	94090	0	UNDEFINED	1	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
		CHEMBL233198	94090	0	UNDEFINED	1	3	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	368	7	1	4	3.7	CC(C)c1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
		2200	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-MQNB(-)	-31	13	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1830	9368	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	9368	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	9368	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	9368	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	9368	44	3H-QNB	-79432	28	Human	3.4	pKi	=	3.4	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		5831	222742	0	3H-MQNB(-)	-190	12	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		208	9638	0	3H-QNB	-50	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		4541	9638	0	3H-QNB	-50	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL1494	9638	0	3H-QNB	-50	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		2200	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		None	223007	0	3H-NMS	-56	6	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	426	7	1	3	4.0	C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5	None
		135398745	9688	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2200	9905	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-NMS	-35	13	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		10090005	222765	0	3H-QNB	-588	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	361	1	0	3	4.4	CN1CCN(CC1)C2=CC3=C(C=CC(=C3)Cl)C(=CC#N)C4=CC=CC=C42	None
		135398737	7745	93	3H-QNB	-22	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-QNB	-22	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-QNB	-22	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-QNB	-22	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-QNB	-22	90	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398745	9688	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-QNB	-38	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		44431369	94758	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
		CHEMBL234253	94758	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	340	6	1	4	2.9	Cc1ccc(CCNCC2(N(C)C)COc3ccccc3OC2)cc1	None
		302	9751	25	3H-MQNB(-)	-4	8	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		4630	9751	25	3H-MQNB(-)	-4	8	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		CHEMBL7634	9751	25	3H-MQNB(-)	-4	8	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	None
		2745	10633	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	10633	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	10633	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	10633	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	10633	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	10633	42	3H-NMS	-46	9	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		154734599	9281	12	3H-MQNB(-)	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-MQNB(-)	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-MQNB(-)	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-MQNB(-)	-1	12	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		44431375	94091	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	None
		CHEMBL233199	94091	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	394	6	1	4	3.9	CN(C)C1(CNCCc2c(Cl)cccc2Cl)COc2ccccc2OC1	None
		44431370	94759	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	None
		CHEMBL234254	94759	0	UNDEFINED	-2	3	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	360	6	1	4	3.2	CN(C)C1(CNCCc2ccc(Cl)cc2)COc2ccccc2OC1	None
		2166	9897	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		305	9897	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		5910	9897	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		CHEMBL550	9897	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		DB01085	9897	49	None	-4	8	Rat	8.3	pKi	=	8.3	Binding	Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranesCompound was evaluated for its affinity towards Muscarinic acetylcholine receptor M2, using [3H]- N-methyl-scopolamine, a radioligand displacement assay in rat heart membranes	Drug Central	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	None
		3823	56995	42	None	-44	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		76973198	56995	42	None	-44	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL157101	56995	42	None	-44	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		44431391	153199	0	UNDEFINED	-1	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	None
		CHEMBL392186	153199	0	UNDEFINED	-1	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	352	6	1	5	2.3	CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1	None
		3389	224490	0	None	1	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
		2812	11551	101	None	-33	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		CHEMBL104	11551	101	None	-33	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		2719	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		5535	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		607	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		CHEMBL76	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		DB00608	7704	74	None	-4	11	Human	8.3	pKi	=	8.3	Binding	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNBActivity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	Drug Central	319	8	1	3	4.8	CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC	None
		441383	27105	57	None	-7	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL1306	27105	57	None	-7	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		2389	10104	118	None	-2818	66	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	None	-2818	66	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	None	-2818	66	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	None	-2818	66	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	None	-2818	66	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		242	7258	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	None	-295	51	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		3294	8787	111	None	-194	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	None	-194	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	None	-194	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	None	-194	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	None	-194	44	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		1016	10519	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2561	10519	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2733526	10519	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5384	10519	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		CHEMBL83	10519	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		DB00675	10519	78	None	-23	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		1209	8439	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	8439	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	8439	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	8439	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	8439	75	None	-22	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		1212	8443	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	None	-1380	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66265	100788	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL248702	100788	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
		1210	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1213	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		2725	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		33036	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		4411	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		616	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		6976	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		716121	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1201353	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL1554789	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		CHEMBL505	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB01114	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		DB13679	7705	51	None	-257	21	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	274	5	0	2	3.8	CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C	None
		1273	8535	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		3450	8535	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		356	8535	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		6172	8535	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		67425	8535	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		CHEMBL360055	8535	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		DB00483	8535	16	None	-1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		15387	52596	55	None	-16	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1531134	52596	55	None	-16	24	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		212	10578	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		2639	10578	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		941651	10578	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		CHEMBL1201	10578	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		DB01623	10578	47	None	-5	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		68617	212306	62	None	-32	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	212306	62	None	-32	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	212306	62	None	-32	26	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		176	7186	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2157	7186	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2566	7186	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		CHEMBL633	7186	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		DB01118	7186	66	None	-2	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2448	106099	70	None	-72	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	106099	70	None	-72	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		4189	213701	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1559	213701	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL91	213701	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		1548955	95356	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		2800	95356	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		CHEMBL2355051	95356	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		3198	212292	76	None	-16	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1201049	212292	76	None	-16	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL808	212292	76	None	-16	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		2274	9947	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	9947	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	9947	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	9947	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	9947	58	None	-100	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		3652	53018	70	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
		CHEMBL1535	53018	70	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	335	9	2	4	3.8	CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12	None
		72064	85176	14	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	Drug Central	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	None
		CHEMBL2110892	85176	14	None	-2	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisDisplacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis	Drug Central	318	8	0	4	3.1	CCN(CC)CCOC(=O)C(c1ccccc1)N1CCCCC1	None
		2774	10640	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		5593	10640	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		7319	10640	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		CHEMBL1200604	10640	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		DB00809	10640	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		DB01199	10640	95	3H-NMS	-3	10	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		310	8703	0	3H-QNB	-25	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		3602	8703	0	3H-QNB	-25	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		CHEMBL3545990	8703	0	3H-QNB	-25	11	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	None
		2200	9905	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-PIRENZEPINE	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		183782	10171	20	3H-NMS	-1202	14	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		237	10171	20	3H-NMS	-1202	14	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL85251	10171	20	3H-NMS	-1202	14	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		2200	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-NMS	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1613	9127	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	3H-QNB	-42	44	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		1353	8692	93	3H-QNB	-5011	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-QNB	-5011	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-QNB	-5011	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-QNB	-5011	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-QNB	-5011	85	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2230	7253	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		296	7253	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		CHEMBL7303	7253	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		DB04365	7253	60	3H-MQNB(-)	-107	10	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	None
		2200	9905	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-MQNB(-)	-31	13	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		2995	211184	53	3H-QNB	-8	23	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	211184	53	3H-QNB	-8	23	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	211184	53	3H-QNB	-8	23	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		15897	9637	0	3H-QNB	-204	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-QNB	-204	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-QNB	-204	36	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		108107	86719	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		156592250	86719	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL1256878	86719	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL212579	86719	38	3H-NMS	-8	16	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		1613	9127	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	3H-QNB	-42	44	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		9905731	175287	0	UNDEFINED	1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	None
		CHEMBL435353	175287	0	UNDEFINED	1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	334	6	1	5	2.2	CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1	None
		191	7191	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	7191	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	7191	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	7191	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	7191	98	None	-56	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		None	223037	0	3H-NMS	1	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	574	9	3	7	4.0	CCCN(CCC)CC1CCCCN1CCNC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4.CS(=O)(=O)O	None
		2337	10030	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	None	-31	62	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		3236	74383	43	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	None
		CHEMBL1902981	74383	43	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	None
		1273	8535	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		3450	8535	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		356	8535	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		6172	8535	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		67425	8535	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		CHEMBL360055	8535	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		DB00483	8535	16	None	-1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	None
		4011	89183	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	89183	49	None	-35	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		44431382	94796	0	UNDEFINED	-2	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	None
		CHEMBL234438	94796	0	UNDEFINED	-2	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	332	6	1	4	3.3	CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1	None
		4098	39279	30	None	-15	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1255739	39279	30	None	-15	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		CHEMBL1411979	39279	30	None	-15	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
		2995	211184	53	None	-8	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	211184	53	None	-8	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	211184	53	None	-8	23	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		11057	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		3468	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL459265	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL64894	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		4735	201894	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		CHEMBL361506	201894	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		CHEMBL55	201894	96	None	-9	10	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	None
		2247	7293	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	7293	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	7293	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	7293	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	7293	81	None	-32	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2381	7450	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		374	7450	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		7128	7450	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		CHEMBL1101	7450	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		DB00810	7450	48	3H-QNB	-15	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	311	5	1	2	4.0	OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1	None
		1530	8963	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	8963	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	8963	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	8963	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	8963	50	None	-43	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		6726	8063	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		7151	8063	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		749	8063	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		CHEMBL648	8063	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		DB01176	8063	51	None	-9	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
		1613	9127	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	None	-42	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		6918558	21286	41	None	-1	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	None
		CHEMBL1201764	21286	41	None	-1	5	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	411	10	1	4	5.4	CC(C)C(=O)Oc1ccc(CO)cc1[C@H](CCN(C(C)C)C(C)C)c1ccccc1	None
		2284	9956	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	9956	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	9956	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	9956	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	9956	33	None	-21	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		135	9310	43	None	-25	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	None	-25	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	None	-25	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	None	-25	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	None	-25	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		237	211644	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL546257	211644	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL554190	211644	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		CHEMBL7568	211644	48	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	None
		3947	213174	53	None	-6	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		CHEMBL87708	213174	53	None	-6	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		187	7043	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	7043	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	7043	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	7043	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	7043	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	7043	39	None	6	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		3191	109635	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	109635	97	None	-8	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		3055	8215	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		313	8215	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		7163	8215	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		CHEMBL936	8215	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		DB01231	8215	44	None	-2	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	None
		3042	8196	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		355	8196	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		868	8196	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		CHEMBL1123	8196	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		DB00804	8196	35	None	-28	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		1353	8692	93	None	-338	85	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	None	-338	85	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	None	-338	85	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	None	-338	85	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	None	-338	85	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranesInhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1935	10506	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		2551	10506	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		6687	10506	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		CHEMBL95	10506	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		DB00382	10506	97	None	-6	6	Mouse	8.2	pKi	=	8.2	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	198	0	1	2	2.7	Nc1c2CCCCc2nc2c1cccc2	None
		2335	18620	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		8478	18620	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL1182210	18620	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL221753	18620	22	None	-2	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		6075	156887	42	None	-7	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		CHEMBL395110	156887	42	None	-7	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
		26987	7736	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		6063	7736	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		671	7736	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		CHEMBL1626	7736	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		DB00283	7736	33	None	-102	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		1734	6904	10	3H-MQNB(-)	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	6904	10	3H-MQNB(-)	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	6904	10	3H-MQNB(-)	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		43815	193699	64	None	-15	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	193699	64	None	-15	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	193699	64	None	-15	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		2726	7706	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	None	-79	72	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2200	9905	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	None	-35	13	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cellsDisplacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		2562	211378	56	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
		CHEMBL1256696	211378	56	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
		CHEMBL73234	211378	56	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards muscarinic m2 receptorBinding affinity towards muscarinic m2 receptor	Drug Central	333	10	0	4	3.4	CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1	None
		1225	8253	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		3958	8253	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		667477	8253	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		CHEMBL860	8253	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		DB01142	8253	26	None	-117	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
		103	10925	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	None	-177	53	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		4601	213526	35	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL1201023	213526	35	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		CHEMBL900	213526	35	None	-2	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
		4976	210358	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		CHEMBL668	210358	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
		154059	10409	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		2457	10409	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		7483	10409	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		CHEMBL1734	10409	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		DB01591	10409	51	None	-3	8	Rat	8.2	pKi	=	8.2	Binding	Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilateBinding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate	Drug Central	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	None
		3652	10869	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		57	10869	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		60809	10869	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		CHEMBL21536	10869	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		DB15357	10869	79	None	-18	18	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cellsDisplacement of [3H]-AFDX-384 from human muscarinic M2 receptor expressed in CHO-K1 cells	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
		2200	9905	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	None	-31	13	Rat	8.2	pKi	=	8.2	Binding	Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypesInhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the muscarinic acetylcholine receptor M2 subtypes	Drug Central	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		1224	8214	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		3100	8214	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		8980	8214	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		916	8214	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		CHEMBL657	8214	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		DB01075	8214	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
		1971	9641	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	9641	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	9641	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	9641	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	9641	38	None	-9	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		5284550	48495	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
		CHEMBL1492500	48495	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	None
		134688371	21201	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
		13765	21201	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
		CHEMBL1200623	21201	10	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	288	1	1	1	5.1	CC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3CC[C@@]21C	None
		134	9292	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-QNB	-154	67	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1979	84101	70	3H-cAMP	-2	4	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		CHEMBL20835	84101	70	3H-cAMP	-2	4	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	169	1	0	3	0.6	CC(=O)OC1CN2CCC1CC2	None
		2389	10104	118	3H-QNB	-2818	66	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-QNB	-2818	66	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-QNB	-2818	66	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-QNB	-2818	66	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-QNB	-2818	66	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		6450478	222791	0	3H-QNB	-1	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	340	0	0	6	3.4	CN1CCN(CC1)C2=NC3=CSC=C3C(=CC#N)C4=CSC=C42	None
		135398745	9688	112	35S-GTPGammaS	-38	65	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	35S-GTPGammaS	-38	65	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	35S-GTPGammaS	-38	65	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	35S-GTPGammaS	-38	65	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2337	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	10030	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-NMS	-70	62	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2337	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-QNB	-31	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		1712	9270	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	9270	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	9270	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	9270	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	9270	43	3H-QNB	-5	22	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		277	8083	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-QNB	-12	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2745	10633	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	10633	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	10633	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	10633	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	10633	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	10633	42	3H-QNB	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		129894468	222884	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	609	2	2	7	6.7	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC	None
		2398	7741	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	7741	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	7741	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	7741	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	7741	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		1734	6904	10	3H-NMS	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		307	6904	10	3H-NMS	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		CHEMBL168067	6904	10	3H-NMS	-12	13	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	None
		2745	10633	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		5572	10633	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		66007	10633	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		7315	10633	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		CHEMBL1490	10633	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		DB00376	10633	42	3H-NMS	-46	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	301	5	1	2	4.3	OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1	None
		135398745	9688	112	None	-38	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	None	-38	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	None	-38	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	None	-38	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		4212	205458	82	None	1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
		CHEMBL1417019	205458	82	None	1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
		CHEMBL58	205458	82	None	1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	None
		73707487	223153	0	None	1	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	355	3	1	4	2.5	CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br	None
		319	8106	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		321	8106	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		444031	8106	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		784	8106	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		CHEMBL1346	8106	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		DB00496	8106	44	None	-18	9	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heartDisplacement of [3H]N-methylscopolamine from muscarinic M2 receptor in rat heart	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		44431387	94093	0	UNDEFINED	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	None
		CHEMBL233201	94093	0	UNDEFINED	-1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	350	6	1	5	2.9	CN(C)C1(CNCCC2CCSCC2)COc2ccccc2OC1	None
		1726	9275	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		1993	9275	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		7438	9275	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		CHEMBL978	9275	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		DB06709	9275	13	None	-3	5	Rat	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesInhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		1726	9275	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		1993	9275	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		7438	9275	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		CHEMBL978	9275	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		DB06709	9275	13	None	-2	5	Human	8.1	pKi	=	8.1	Binding	Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2	Drug Central	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	None
		135398737	7745	93	None	-22	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-22	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-22	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-22	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-22	90	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		3042	8196	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		355	8196	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		868	8196	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		CHEMBL1123	8196	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		DB00804	8196	35	None	-12	15	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
		135398737	7745	93	None	-6	90	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-6	90	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-6	90	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-6	90	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-6	90	Rat	8.1	pKi	=	8.1	Binding	Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.Compound was tested for the binding affinity against rat heart Muscarinic acetylcholine receptor M2 by Radio ligand [3H]quinuclidinyl binding assay.	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		21855	91021	42	None	-7	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
		CHEMBL22108	91021	42	None	-7	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	None
		62865	8057	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	8057	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	8057	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	8057	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	8057	0	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		2774	10640	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		5593	10640	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		7319	10640	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		CHEMBL1200604	10640	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		DB00809	10640	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		DB01199	10640	95	None	-1	10	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	None
		6472	209526	35	None	-4	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	None
		CHEMBL61946	209526	35	None	-4	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesDisplacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates	Drug Central	289	7	0	3	3.4	CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1	None
		24096961	222886	0	3H-MQNB(-)	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	422	4	3	6	2.5	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.OS(=O)(=O)O	None
		319	8106	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		321	8106	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		444031	8106	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		784	8106	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		CHEMBL1346	8106	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		DB00496	8106	44	None	-20	9	Human	8.1	pKi	=	8.1	Binding	GRAC: human M2 antagonistGRAC: human M2 antagonist	Drug Central	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	None
		124087	8171	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		7157	8171	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		814	8171	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		CHEMBL1172	8171	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		DB00967	8171	114	None	-6	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
		1371	8704	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		24199	8704	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		323	8704	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		CHEMBL1201325	8704	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		DB06787	8704	11	None	-4	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	None
		10921	19817	23	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		2968	19817	23	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		CHEMBL1190	19817	23	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	258	11	0	0	3.5	C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C	None
		4919	213013	23	None	-3	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		CHEMBL86715	213013	23	None	-3	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	5	1	2	3.9	OC(CCN1CCCC1)(c1ccccc1)C1CCCCC1	None
		5648	85186	9	None	-2	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
		CHEMBL2107687	85186	9	None	-2	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
		CHEMBL2111176	85186	9	None	-2	5	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	306	9	0	2	3.8	CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1	None
		2270	9945	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		4811	9945	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		4913	9945	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		CHEMBL640	9945	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		DB01035	9945	69	None	-	1	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	235	6	2	3	1.3	CCN(CCNC(=O)c1ccc(cc1)N)CC	None
		1712	9270	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	9270	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	9270	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	9270	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	9270	43	None	-5	22	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		100	10577	58	None	-19	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	None	-19	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	None	-19	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	None	-19	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	None	-19	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2286	9957	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	9957	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	9957	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	9957	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	9957	51	None	-3	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		154825138	222817	0	3H-PIRENZEPINE	-1	12	Rat	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	345	2	0	3	4.4	CC1CCCC(N1C)C=CC2C3CCCCC3CC4C2C(OC4=O)C	None
		187	7043	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		294	7043	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		65	7043	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		8593	7043	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		CHEMBL667	7043	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		DB03128	7043	39	3H-MQNB(-)	-6	9	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	None
		279	8442	26	3H-QNB	-14	17	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		49381	8442	26	3H-QNB	-14	17	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		CHEMBL63756	8442	26	3H-QNB	-14	17	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		1212	8443	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-QNB	-1380	65	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		None	223035	0	3H-NMS	-5	5	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	311	3	1	2	3.9	C1CCC(CC1)C(C#CCN2CCCCC2)(C3=CC=CC=C3)O	None
		154734599	9281	12	3H-QNB	1	12	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		327	9281	12	3H-QNB	1	12	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		4108	9281	12	3H-QNB	1	12	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		CHEMBL27673	9281	12	3H-QNB	1	12	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	None
		135398745	9688	112	3H-QNB	-38	65	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-QNB	-38	65	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-QNB	-38	65	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-QNB	-38	65	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		11976	7707	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	7707	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	7707	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	7707	59	3H-QNB	-23	24	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		2200	9905	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-NMS	-31	13	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		277	8083	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	None	-12	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1427	8794	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	8794	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	8794	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	8794	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	8794	54	None	1	27	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		2028	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		359	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		4634	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		CHEMBL1231	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		DB01062	9753	80	None	-8	11	Human	8.1	pKi	=	8.1	Binding	Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cellsDisplacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		5831	222742	0	None	-1	12	Mouse	8.1	pKi	=	8.1	Binding	Ability to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]OXO-M) from mouse cerebral cortex	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		180	7189	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	7189	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	7189	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	7189	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	7189	56	None	-27	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2028	9753	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		359	9753	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		4634	9753	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		CHEMBL1231	9753	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		DB01062	9753	80	UNDEFINED	-8	11	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		1086	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		3290	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		7181	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		CHEMBL1206	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		DB00392	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Drug Central	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	None
		4904	162300	48	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	None
		CHEMBL404215	162300	48	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	295	5	1	2	3.8	OC(CCN1CCCCC1)(c1ccccc1)c1ccccc1	None
		2028	9753	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		359	9753	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		4634	9753	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		CHEMBL1231	9753	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		DB01062	9753	80	None	-5	11	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
		2705	10614	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		360	10614	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		443879	10614	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		CHEMBL1382	10614	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		DB01036	10614	64	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat Muscarinic acetylcholine receptor M2Affinity for rat Muscarinic acetylcholine receptor M2	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		5831	222742	0	None	-190	12	Rat	8.1	pKi	=	8.1	Binding	Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.	Drug Central	182	3	1	2	-3.2	C[N+](C)(C)CCOC(=O)N.[Cl-]	None
		2705	10614	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		360	10614	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		443879	10614	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		CHEMBL1382	10614	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		DB01036	10614	64	None	-1	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cellsDisplacement of [3H]N-methyl Scopolamine from human cloned muscarinic M2 receptor expressed in CHO cells	Drug Central	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	None
		1201549	7384	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		333	7384	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		7601	7384	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL1201203	7384	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL438151	7384	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		DB00245	7384	24	None	-3	20	Rat	8.1	pKi	=	8.1	Binding	Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		24835791	222883	0	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		44431386	155804	0	UNDEFINED	1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	None
		CHEMBL394255	155804	0	UNDEFINED	1	3	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	332	5	1	5	2.1	CN(C)C1(CNCC=C2CCOCC2)COc2ccccc2OC1	None
		25897919	62426	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		657309	62426	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1464005	62426	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1621597	62426	14	None	-1	8	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		1201549	7384	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		333	7384	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		7601	7384	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL1201203	7384	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		CHEMBL438151	7384	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		DB00245	7384	24	None	-5	20	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
		11968014	19530	5	None	-4	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
		CHEMBL1187846	19530	5	None	-4	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	303	4	1	5	0.9	CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@@H]1O[C@H]12	None
		24835791	222883	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		123134663	224507	0	None	-1	3	Dog	8.1	pKi	=	8.1	Binding	radioligand ([3H]QNB) displacement assayradioligand ([3H]QNB) displacement assay	Drug Central	330	2	0	2	5.4	C[N@+]12CCCC[C@@H]1CCC(C2)=C(C1=CC=CS1)C1=CC=CS1	None
		12057539	214820	42	None	-2	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	None	-2	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	None	-2	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		135398737	7745	93	3H-QNB	-22	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-QNB	-22	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-QNB	-22	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-QNB	-22	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-QNB	-22	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	10577	58	3H-QNB	-19	54	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-QNB	-19	54	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-QNB	-19	54	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-QNB	-19	54	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-QNB	-19	54	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1427	8794	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	8794	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	8794	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	8794	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	8794	54	3H-QNB	1	27	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		25897919	62426	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		657309	62426	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1464005	62426	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL1621597	62426	14	None	-4	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	332	5	1	3	2.9	CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2	None
		12057539	214820	42	None	-2	21	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	None	-2	21	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	None	-2	21	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardiumBinding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		10470	9266	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		1689	9266	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		4057	9266	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		CHEMBL524004	9266	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		DB04843	9266	7	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis	Drug Central	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	None
		11693	8608	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		3494	8608	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		4302	8608	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		7459	8608	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		CHEMBL1201335	8608	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		DB00986	8608	16	None	-2	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	None
		154417	29953	60	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	None
		CHEMBL1331216	29953	60	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	None
		12057539	214820	42	None	-17	21	Mouse	8.0	pKi	=	8.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	None	-17	21	Mouse	8.0	pKi	=	8.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	None	-17	21	Mouse	8.0	pKi	=	8.0	Binding	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortexAbility to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	Drug Central	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		2293	9960	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		329	9960	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		4934	9960	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		CHEMBL1180725	9960	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		DB00782	9960	27	None	-2	4	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	None
		10129	10095	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		11753673	10095	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		5303	10095	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		CHEMBL3833319	10095	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		DB11855	10095	0	None	-1	5	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	None
		316	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		317	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		71183	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL3140030	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL376897	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		DB00462	9611	19	None	-6	9	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	Drug Central	318	4	1	4	1.1	OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		367	10596	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		5487427	10596	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		8592	10596	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL1900528	10596	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL3305968	10596	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		CHEMBL4650755	10596	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		DB01409	10596	12	None	-19	8	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heartDisplacement of [3H]-NMS from Sprague-Dawley rat muscarinic M2 receptor in heart	Drug Central	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	None
		11519069	10711	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		11519070	10711	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		4816	10711	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		7354	10711	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		CHEMBL1187833	10711	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		DB09076	10711	3	None	-1	5	Human	8.0	pKi	=	8.0	Binding	radioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligandradioligand binding assays in CHO cells expressing human M1, M2, or M3 receptors in a scintillation proximity assay with 0.5 nM [3H]-N-methyl scopolamine as the ligand	Drug Central	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	None
		44431367	94757	0	UNDEFINED	-4	3	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	None
		CHEMBL234252	94757	0	UNDEFINED	-4	3	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	6	1	4	2.6	CN(C)C1(CNCCc2ccccc2)COc2ccccc2OC1	None
		2200	9905	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		328	9905	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		4848	9905	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		CHEMBL9967	9905	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		DB00670	9905	46	3H-NMS	-35	13	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	None
		24835791	222883	0	3H-MQNB(-)	1	2	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	362	4	1	3	3.3	C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4	None
		11954224	222732	0	3H-QNB	-1047	59	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		46780481	114308	20	3H-NMS	-436	53	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-NMS	-436	53	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-NMS	-436	53	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-NMS	-436	53	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		135398745	9688	112	3H-NMS	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	9688	112	3H-NMSP	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-NMS	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-NMSP	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-NMS	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-NMSP	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-NMS	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-NMSP	-38	65	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		129894468	222884	0	3H-MQNB(-)	-	1	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	609	2	2	7	6.7	CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC	None
		10104	10339	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
		6604866	10339	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
		CHEMBL1493369	10339	12	None	2	6	Human	7.5	pKi	=	7.5	Binding	Binding to hM2 receptors expressed in CHO cells.Binding to hM2 receptors expressed in CHO cells.	Guide to Pharmacology	292	5	0	2	4.1	CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C	12593665
		10129	10095	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		11753673	10095	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		5303	10095	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		CHEMBL3833319	10095	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		DB11855	10095	0	None	-1	5	Human	9.5	pKi	=	9.5	Binding	Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM<sub>2</sub> receptor, and displacement of [<sup>3</sup>H]NMS tracer.	Guide to Pharmacology	597	10	2	6	4.8	O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C	29736245
		1201549	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		333	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		7601	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		CHEMBL1201203	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		CHEMBL438151	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		DB00245	7384	24	None	-3	20	Rat	8.6	pKi	=	8.6	Binding	Displacement binding assay using homogenised rat caudate putamen.Displacement binding assay using homogenised rat caudate putamen.	Guide to Pharmacology	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	7562926
		1086	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		3290	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		7181	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		CHEMBL1206	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		DB00392	8371	27	None	-1	2	Rat	8.1	pKi	=	8.1	Binding	Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.Displacement of [<sup<3</sup>H]QNB binding in rat hindbrain brain homogenate.	Guide to Pharmacology	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	2904117
		123603	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		2684	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		584	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		9658	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		CHEMBL168815	7670	29	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [<sup>3</sup>H]QNB from cloned receptor.Displacement of [<sup>3</sup>H]QNB from cloned receptor.	Guide to Pharmacology	199	0	0	3	1.6	CC1SCC2(O1)CN1CCC2CC1	9399977
		367	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		367	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		367	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		367	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		5487427	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		5487427	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		5487427	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		5487427	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		8592	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		8592	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		8592	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		8592	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		CHEMBL1900528	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		CHEMBL1900528	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		CHEMBL1900528	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		CHEMBL1900528	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		CHEMBL3305968	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		CHEMBL3305968	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		CHEMBL3305968	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		CHEMBL3305968	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		CHEMBL4650755	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		CHEMBL4650755	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		CHEMBL4650755	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		CHEMBL4650755	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		DB01409	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	19653626
		DB01409	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	21036042
		DB01409	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	22854200
		DB01409	10596	12	None	-2	8	Human	10.3	pKi	=	10.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	392	4	1	6	2.3	O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3	8441333
		8598	8055	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1053	16	2	11	9.9	O=C(Cc1ccc2c(c1)C(C)(C)C1=C3C=C4C(OC3CCN21)CC[N+]1=C4C(C)(C)c2c1ccc(c2)S([O-])([O-])[O-])NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
		91827377	8055	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1053	16	2	11	9.9	O=C(Cc1ccc2c(c1)C(C)(C)C1=C3C=C4C(OC3CCN21)CC[N+]1=C4C(C)(C)c2c1ccc(c2)S([O-])([O-])[O-])NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
		2370	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		2370	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		297	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		297	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		358	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		358	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		CHEMBL1482	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		CHEMBL1482	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		DB01019	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	7620715
		DB01019	7410	31	None	-1	5	Human	4.0	pKi	=	4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	161	3	1	2	0.2	CC(C[N+](C)(C)C)OC(=O)N	9224827
		2166	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		2166	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		305	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		305	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		5910	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		5910	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		CHEMBL550	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		CHEMBL550	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		DB01085	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	7620715
		DB01085	9897	49	None	-34	8	Human	4.9	pKi	=	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	208	3	0	4	1.2	CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C	9224827
		2551	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		2551	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		298	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		298	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		488	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		488	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		CHEMBL965	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		CHEMBL965	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		DB00411	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	12235229
		DB00411	7581	23	None	-6	11	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9224827
		2230	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
		2230	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
		2230	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
		296	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
		296	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
		296	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
		CHEMBL7303	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
		CHEMBL7303	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
		CHEMBL7303	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
		DB04365	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	32717485
		DB04365	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	7620715
		DB04365	7253	60	None	-75	10	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	155	1	0	3	0.4	COC(=O)C1=CCCN(C1)C	9224827
		129786	8672	0	None	-141	4	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	2	3	5	0.8	NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	8813552
		3276	8672	0	None	-141	4	Rat	5.3	pKi	=	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	2	3	5	0.8	NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	8813552
		187	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		187	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		187	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		294	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		294	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		294	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		65	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		65	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		65	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		8593	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		8593	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		8593	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		CHEMBL667	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		CHEMBL667	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		CHEMBL667	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		DB03128	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	12235229
		DB03128	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	23798605
		DB03128	7043	39	None	6	9	Human	5.4	pKi	=	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9224827
		302	9751	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
		302	9751	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
		4630	9751	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
		4630	9751	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
		CHEMBL7634	9751	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	7620715
		CHEMBL7634	9751	25	None	-34	8	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9224827
		24768606	10802	58	None	-39	5	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
		3274	10802	58	None	-39	5	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
		CHEMBL1628667	10802	58	None	-39	5	Human	6.2	pKi	=	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	432	6	1	8	1.1	O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2	19407080
		2200	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		2200	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		2200	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		2200	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		2200	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		2200	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		2200	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		2200	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		328	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		328	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		328	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		328	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		328	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		328	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		328	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		328	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		4848	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		4848	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		4848	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		4848	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		4848	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		4848	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		4848	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		4848	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		CHEMBL9967	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		CHEMBL9967	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		CHEMBL9967	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		CHEMBL9967	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		CHEMBL9967	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		CHEMBL9967	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		CHEMBL9967	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		CHEMBL9967	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		DB00670	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	12049493
		DB00670	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	16188951
		DB00670	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1994002
		DB00670	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2043926
		DB00670	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2704370
		DB00670	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	7925952
		DB00670	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9113359
		DB00670	9905	46	None	-35	13	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		1273	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		1273	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		1273	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		3450	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		3450	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		3450	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		356	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		356	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		356	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		6172	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		6172	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		6172	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		67425	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		67425	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		67425	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		CHEMBL360055	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		CHEMBL360055	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		CHEMBL360055	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		DB00483	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	12815174
		DB00483	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	30213802
		DB00483	8535	16	None	-1	3	Human	6.7	pKi	=	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		107867	9748	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
		107867	9748	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		309	9748	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
		309	9748	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		CHEMBL17045	9748	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2704370
		CHEMBL17045	9748	55	None	2	11	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		5282426	8248	0	None	-27	6	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
		7549	8248	0	None	-27	6	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
		CHEMBL108947	8248	0	None	-27	6	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	0	2	4.7	CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C	8100134
		154059	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		154059	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		2457	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		2457	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		7483	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		7483	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		CHEMBL1734	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		CHEMBL1734	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		DB01591	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	12122494
		DB01591	10409	51	None	-12	8	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	2	0	3	3.9	O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2	20590605
		3652	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		3652	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		3652	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		57	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		57	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		57	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		60809	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		60809	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		60809	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		CHEMBL21536	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		CHEMBL21536	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		CHEMBL21536	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		DB15357	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10323594
		DB15357	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	36782010
		DB15357	10869	79	None	-18	18	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
		2774	10640	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		5593	10640	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		7319	10640	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		CHEMBL1200604	10640	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		DB00809	10640	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		DB01199	10640	95	None	-1	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	284	6	1	3	2.2	CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1	27085897
		1726	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		1726	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		1993	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		1993	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		7438	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		7438	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		CHEMBL978	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		CHEMBL978	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		DB06709	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	7620715
		DB06709	9275	13	None	-3	5	Rat	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	3	0	2	0.6	CC(C[N+](C)(C)C)OC(=O)C	9622546
		319	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		319	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		319	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		321	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		321	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		321	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		444031	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		444031	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		444031	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		784	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		784	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		784	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		CHEMBL1346	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		CHEMBL1346	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		CHEMBL1346	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		DB00496	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	11303071
		DB00496	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	20590605
		DB00496	8106	44	None	-20	9	Human	7.3	pKi	=	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	9671109
		129140	10706	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	2043926
		129140	10706	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	9671109
		8583	10706	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	2043926
		8583	10706	0	None	-10	4	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	2	1	3	4.3	CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2	9671109
		154734599	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
		154734599	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
		154734599	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
		154734599	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
		154734599	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
		154734599	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		327	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
		327	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
		327	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
		327	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
		327	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
		327	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		4108	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
		4108	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
		4108	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
		4108	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
		4108	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
		4108	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		CHEMBL27673	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	16188951
		CHEMBL27673	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	1994002
		CHEMBL27673	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	2704370
		CHEMBL27673	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	8759038
		CHEMBL27673	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9113359
		CHEMBL27673	9281	12	None	1	12	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		180	7189	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		200	7189	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		2160	7189	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		CHEMBL629	7189	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		DB00321	7189	56	None	-27	40	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	8100134
		2028	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		359	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		4634	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		CHEMBL1231	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		DB01062	9753	80	None	-8	11	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		2028	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		2028	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		359	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		359	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		4634	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		4634	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		CHEMBL1231	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		CHEMBL1231	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		DB01062	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	20590605
		DB01062	9753	80	None	-8	11	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	22243489
		324	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
		324	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
		324	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
		324	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		6436265	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
		6436265	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
		6436265	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
		6436265	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		CHEMBL277642	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1331410
		CHEMBL277642	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	1994002
		CHEMBL277642	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	7925952
		CHEMBL277642	8706	15	None	-1	9	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		119357	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
		119357	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
		3264	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
		3264	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
		368	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
		368	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
		CHEMBL279453	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	1994002
		CHEMBL279453	7092	49	None	1	6	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	9	2	5	4.5	CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC	27085897
		1734	6904	10	None	-9	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
		307	6904	10	None	-9	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
		CHEMBL168067	6904	10	None	-9	13	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1994002
		129989	7239	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
		129989	7239	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
		8584	7239	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
		8584	7239	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
		CHEMBL43383	7239	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1994002
		CHEMBL43383	7239	51	None	-1	9	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	463	9	1	5	4.5	CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9671109
		2705	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		2705	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		360	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		360	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		443879	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		443879	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		CHEMBL1382	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		CHEMBL1382	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		DB01036	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	20590605
		DB01036	10614	64	None	-1	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	9671109
		174174	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		174174	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		174174	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		174174	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		260	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		260	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		260	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		260	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		320	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		320	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		320	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		320	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		CHEMBL517712	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		CHEMBL517712	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		CHEMBL517712	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		CHEMBL517712	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		DB00572	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	11303071
		DB00572	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	12049493
		DB00572	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	27085897
		DB00572	7311	49	None	-7	14	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	3443095
		8586	7089	0	None	-19	4	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	5	2	3	1.8	CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2	20590605
		9862598	7089	0	None	-19	4	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	5	2	3	1.8	CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2	20590605
		3000322	10335	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
		3000322	10335	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
		330	10335	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
		330	10335	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
		CHEMBL569713	10335	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
		CHEMBL569713	10335	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
		DB00747	10335	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	12049493
		DB00747	10335	38	None	-5	6	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	303	4	1	5	0.9	OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C	1346637
		8600	7130	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1025	18	4	16	4.7	O=C(c1ccc(c(c1)C(=O)[O-])c1c2ccc(c(c2oc2c1ccc(=[NH2+])c2S([O-])([O-])[O-])S([O-])([O-])[O-])N)NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
		91827379	7130	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1025	18	4	16	4.7	O=C(c1ccc(c(c1)C(=O)[O-])c1c2ccc(c(c2oc2c1ccc(=[NH2+])c2S([O-])([O-])[O-])S([O-])([O-])[O-])N)NCCCCCCCCCCN1CCN(CC1)CC(=O)n1c2ccccc2[nH]c(=O)c2c1c(C)sc2	23357106
		30843	8184	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		354	8184	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		831	8184	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		CHEMBL1908364	8184	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		DB08997	8184	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		10470	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		1689	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		4057	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		CHEMBL524004	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		DB04843	9266	7	None	-4	3	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	4	1	3	2.7	O=C(C(c1ccccc1)(c1ccccc1)O)OC1CCC[N+](C1)(C)C	24844758
		2293	9960	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		329	9960	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		4934	9960	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		CHEMBL1180725	9960	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		DB00782	9960	27	None	-2	4	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	6	0	3	4.7	O=C(C1c2ccccc2Oc2c1cccc2)OCC[N+](C(C)C)(C(C)C)C	12049493
		11354367	10588	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	668	19	1	6	7.1	CCCN(C1CCN(CC1)Cc1c(OC)cccc1OC)CCCCCCCN1CC[C@H](C1)C(c1ccccc1)(c1ccccc1)C(=O)N	17478612
		3255	10588	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	668	19	1	6	7.1	CCCN(C1CCN(CC1)Cc1c(OC)cccc1OC)CCCCCCCN1CC[C@H](C1)C(c1ccccc1)(c1ccccc1)C(=O)N	17478612
		325	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		325	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		3746	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		3746	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		657308	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		657308	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		CHEMBL1615433	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		CHEMBL1615433	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		DB00332	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	11303071
		DB00332	8843	0	None	-3	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	332	5	1	3	2.9	OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C	19653626
		132947	10636	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
		361	10636	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
		CHEMBL265256	10636	9	None	1	9	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1124	29	4	13	10.2	CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C	7805774
		11519069	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		11519069	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		11519070	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		11519070	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		4816	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		4816	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		7354	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		7354	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		CHEMBL1187833	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		CHEMBL1187833	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		DB09076	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	19317446
		DB09076	10711	3	None	-1	5	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	8	1	2	5.1	OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1	23435542
		42519285	9355	15	None	-60	5	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
		8591	9355	15	None	-60	5	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
		CHEMBL3185781	9355	15	None	-60	5	Human	4.5	pKi	>	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	7	0	6	3.7	CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C	24692176
		314	9469	0	None	-1122018	5	Human	5.0	pKi	>	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10799315
		313	9468	0	None	-407	6	Human	6.0	pKi	>	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7925952
		134	9292	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	None	-154	67	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		2865	10915	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	None	-1659	53	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		3337	213146	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	None	-120	40	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		46780481	114308	20	None	-436	53	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	None	-436	53	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	None	-436	53	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	None	-436	53	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		11954224	222732	0	None	-1047	59	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		3012003	222924	0	None	-1	12	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	311	5	0	3	3.8	CN1CCC(C(C1)COC2=CC=C(C=C2)OC)C3=CC=CC=C3	None
		2895	210371	41	None	-1	8	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		CHEMBL669	210371	41	None	-1	8	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
		11976	7707	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	7707	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	7707	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	7707	59	None	-23	24	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		4066	211405	78	None	-1	7	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		CHEMBL73451	211405	78	None	-1	7	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	None
		24096961	222886	0	None	-	1	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	422	4	3	6	2.5	COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.OS(=O)(=O)O	None
		11757797	9617	0	None	1	5	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
		292	9617	0	None	1	5	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
		10938	8483	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
		299	8483	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
		3256	8483	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
		CHEMBL2110739	8483	0	None	1	4	Human	4.5	pKi	None	4.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	140	2	0	1	1.5	C[N+](Cc1ccco1)(C)C	9224827
		30844	9090	0	None	-1	2	Rat	4.8	pKi	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		358	9090	0	None	-1	2	Rat	4.8	pKi	None	4.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		300	9288	15	None	1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
		4141	9288	15	None	1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
		CHEMBL92387	9288	15	None	1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	154	2	0	1	1.8	Cc1ccc(o1)C[N+](C)(C)C	9224827
		303	9752	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
		4629	9752	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
		8595	9752	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
		CHEMBL44674	9752	17	None	-1	6	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	2	0	1	0.3	O=C1CCCN1CC#CC[N+](C)(C)C	9224827
		30844	9090	0	None	1	2	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		358	9090	0	None	1	2	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		290	9251	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		4022	9251	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		5926	9251	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		CHEMBL40554	9251	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		CHEMBL74300	9251	6	None	-12	7	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	316	3	1	2	-0.4	O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]	7680092
		22991950	9108	0	None	-3	6	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	448	7	2	2	5.9	OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C	12235229
		326	9108	0	None	-3	6	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	448	7	2	2	5.9	OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C	12235229
		1273	8535	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		3450	8535	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		356	8535	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		6172	8535	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		67425	8535	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		CHEMBL360055	8535	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		DB00483	8535	16	None	-1	3	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	510	21	0	3	5.5	CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC	9454790
		2229	7252	22	None	1	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
		295	7252	22	None	1	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
		CHEMBL128365	7252	22	None	1	6	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	2	0	3	0.4	CN1CC(=CCC1)C(=O)OCC#C	9224827
		2551	7581	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		298	7581	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		488	7581	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		CHEMBL965	7581	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		DB00411	7581	23	None	-3	11	Rat	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	147	3	1	2	-0.2	NC(=O)OCC[N+](C)(C)C	9454790
		107867	9748	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
		107867	9748	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
		107867	9748	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		309	9748	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
		309	9748	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
		309	9748	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		CHEMBL17045	9748	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	1325587
		CHEMBL17045	9748	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	2846274
		CHEMBL17045	9748	55	None	-14	11	Rat	6.0	pKi	None	6.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	421	6	1	5	3.5	CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC	9454790
		2200	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		2200	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		2200	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		328	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		328	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		328	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		4848	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		4848	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		4848	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		CHEMBL9967	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		CHEMBL9967	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		CHEMBL9967	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		DB00670	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	1325587
		DB00670	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	2846274
		DB00670	9905	46	None	-31	13	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	2	1	5	1.6	CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2	9454790
		308	8841	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
		308	8841	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
		3603	8841	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
		3603	8841	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
		CHEMBL1256682	8841	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	12049493
		CHEMBL1256682	8841	23	None	-11	9	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	349	6	1	2	4.2	Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O	8759038
		187	7043	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		294	7043	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		65	7043	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		8593	7043	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		CHEMBL667	7043	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		DB03128	7043	39	None	-6	9	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	146	3	0	2	0.3	CC(=O)OCC[N+](C)(C)C	9454790
		302	9751	25	None	-4	8	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
		4630	9751	25	None	-4	8	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
		CHEMBL7634	9751	25	None	-4	8	Rat	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	206	2	0	2	0.7	O=C1CCCN1CC#CCN1CCCC1	9454790
		3042	8196	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		355	8196	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		868	8196	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		CHEMBL1123	8196	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		DB00804	8196	35	None	-28	15	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	2704370
		310	8703	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		310	8703	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
		310	8703	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		3602	8703	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		3602	8703	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
		3602	8703	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		CHEMBL3545990	8703	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		CHEMBL3545990	8703	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	8759038
		CHEMBL3545990	8703	0	None	-56	11	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		124226	8702	0	None	-19	5	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		322	8702	0	None	-19	5	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	2	4.7	OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	2704370
		310	8703	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
		310	8703	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		3602	8703	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
		3602	8703	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		CHEMBL3545990	8703	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	1325587
		CHEMBL3545990	8703	0	None	-25	11	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	6	1	2	4.0	O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1	9454790
		1427	8794	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		357	8794	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		3696	8794	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		CHEMBL11	8794	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		DB00458	8794	54	None	1	27	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	9454790
		10259588	10851	0	None	-	1	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	604	12	0	8	2.6	O=C1N(CO/N=C\c2cc[n+](cc2)CCC[n+]2ccc(cc2)/C=N\OCN2C(=O)c3c(C2=O)cccc3)C(=O)c2c1cccc2	12815174
		363	10851	0	None	-	1	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	604	12	0	8	2.6	O=C1N(CO/N=C\c2cc[n+](cc2)CCC[n+]2ccc(cc2)/C=N\OCN2C(=O)c3c(C2=O)cccc3)C(=O)c2c1cccc2	12815174
		10426487	9616	7	None	-3	5	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
		291	9616	7	None	-3	5	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
		CHEMBL99521	9616	7	None	-3	5	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	325	3	0	5	2.8	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1	11504829
		154734599	9281	12	None	-1	12	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		327	9281	12	None	-1	12	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		4108	9281	12	None	-1	12	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		CHEMBL27673	9281	12	None	-1	12	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	582	29	4	6	7.2	COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC	9454790
		130169	10377	0	None	-26	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	2704370
		331	10377	0	None	-26	5	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	2	2.1	C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O	2704370
		1371	8704	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		24199	8704	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		323	8704	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		CHEMBL1201325	8704	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		DB06787	8704	11	None	-4	5	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	317	4	1	2	2.8	C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O	2704370
		167962	10841	4	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		362	10841	4	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		CHEMBL31599	10841	4	None	-	1	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	548	15	0	4	4.1	O=C1N(CCC[N+](CCCCCC[N+](CCCN2C(=O)c3c(C2=O)cccc3)(C)C)(C)C)C(=O)c2c1cccc2	12815174
		324	8706	15	None	-1	9	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		6436265	8706	15	None	-1	9	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		CHEMBL277642	8706	15	None	-1	9	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	345	2	0	3	4.4	C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2	9454790
		10062394	9821	1	None	-6	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
		304	9821	1	None	-6	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
		CHEMBL130715	9821	1	None	-6	4	Human	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	283	6	0	5	3.5	CCCCCSc1nsnc1C1=CCCN(C1)C	9224827
		1734	6904	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
		1734	6904	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
		307	6904	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
		307	6904	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
		CHEMBL168067	6904	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	1325587
		CHEMBL168067	6904	10	None	-12	13	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	324	4	0	2	3.6	O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C	9454790
		293	9618	0	None	-2	5	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
		9985526	9618	0	None	-2	5	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	572	6	0	10	3.9	C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2	11504829
		10350027	8210	0	None	-	1	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		364	8210	0	None	-	1	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		365	8210	0	None	-	1	Human	8.5	pKi	None	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	576	15	0	4	4.7	Cc1cccc2c1C(=O)N(C2=O)CCC[N+](CCCCCC[N+](CCCN1C(=O)c2c(C1=O)c(C)ccc2)(C)C)(C)C	12815174
		350	10329	7	None	26	2	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
		9867750	10329	7	None	26	2	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
		CHEMBL73341	10329	7	None	26	2	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	0	5	4.4	COc1ccc(cc1)S(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCCC1)C#N	10069520
		30843	8184	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		354	8184	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		831	8184	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		CHEMBL1908364	8184	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		DB08997	8184	0	None	-1	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	4	1	3	3.3	O=C1CC[C@](C(=O)N1)(C1CCN(CC1)Cc1ccccc1)c1ccccc1	9454790
		174174	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		174174	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
		260	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		260	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
		320	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		320	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
		CHEMBL517712	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		CHEMBL517712	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790
		DB00572	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	1325587
		DB00572	7311	49	None	-4	14	Rat	9.1	pKi	None	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	4	1	4	1.9	OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C	9454790

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Ligand source activities (1 row/activity)