Ligand source activities (1 row/activity)





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44271661 168575 0 None -1 3 Human 9.3 pEC50 = 9.3 Functional
Effective concentration showing agonistic activity towards Human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells was determinedEffective concentration showing agonistic activity towards Human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells was determined
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL414185 168575 0 None -1 3 Human 9.3 pEC50 = 9.3 Functional
Effective concentration showing agonistic activity towards Human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells was determinedEffective concentration showing agonistic activity towards Human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells was determined
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
44271661 168575 0 None -1 3 Human 9.3 pEC50 = 9.3 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL414185 168575 0 None -1 3 Human 9.3 pEC50 = 9.3 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
44271661 168575 0 None -1 3 Human 9.3 pEC50 = 9.3 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL414185 168575 0 None -1 3 Human 9.3 pEC50 = 9.3 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 233 4 2 5 0.9 COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
10934575 211265 0 None -8 5 Human 9.0 pEC50 = 9.0 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72441 211265 0 None -8 5 Human 9.0 pEC50 = 9.0 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1 10.1021/jm000542r
10198532 214475 0 None -1 3 Human 8.0 pEC50 = 8 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 232 4 3 4 0.5 CNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL95523 214475 0 None -1 3 Human 8.0 pEC50 = 8 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 232 4 3 4 0.5 CNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
44343236 118141 0 None -15 3 Human 7.0 pEC50 = 7 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 243 4 1 5 1.7 c1ccc(-c2ccno2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
CHEMBL327005 118141 0 None -15 3 Human 7.0 pEC50 = 7 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 243 4 1 5 1.7 c1ccc(-c2ccno2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(02)00753-9
11506641 74160 3 None - 1 Rat 6.0 pEC50 = 6 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 197 5 1 4 1.5 O=[N+]([O-])OCCCc1ccc(O)cc1 10.1021/jm0510530
CHEMBL188760 74160 3 None - 1 Rat 6.0 pEC50 = 6 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 197 5 1 4 1.5 O=[N+]([O-])OCCCc1ccc(O)cc1 10.1021/jm0510530
11645786 74061 0 None - 1 Rat 5.0 pEC50 = 5 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 339 7 1 6 3.0 Cc1c(C)c2c(c(C)c1O)CCC(C)(COCCCO[N+](=O)[O-])O2 10.1021/jm0510530
CHEMBL188200 74061 0 None - 1 Rat 5.0 pEC50 = 5 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 339 7 1 6 3.0 Cc1c(C)c2c(c(C)c1O)CCC(C)(COCCCO[N+](=O)[O-])O2 10.1021/jm0510530
44411389 83932 0 None - 1 Rat 5.0 pEC50 = 5 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 352 4 0 5 3.8 COc1ccc(Cc2nn(C(C)(C)C)c(=O)c3ccccc23)cc1OC 10.1016/j.bmcl.2006.02.003
CHEMBL207846 83932 0 None - 1 Rat 5.0 pEC50 = 5 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 352 4 0 5 3.8 COc1ccc(Cc2nn(C(C)(C)C)c(=O)c3ccccc23)cc1OC 10.1016/j.bmcl.2006.02.003
6604803 123296 2 None -194 4 Rat 6.0 pEC50 = 6.0 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1 10.1021/jm960354u
CHEMBL336161 123296 2 None -194 4 Rat 6.0 pEC50 = 6.0 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1 10.1021/jm960354u
11684556 73979 0 None - 1 Rat 7.0 pEC50 = 7.0 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 488 7 1 7 4.5 CC(C)(C)c1cc(CCCOc2no[n+]([O-])c2S(=O)(=O)c2ccccc2)cc(C(C)(C)C)c1O 10.1021/jm0510530
CHEMBL187824 73979 0 None - 1 Rat 7.0 pEC50 = 7.0 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 488 7 1 7 4.5 CC(C)(C)c1cc(CCCOc2no[n+]([O-])c2S(=O)(=O)c2ccccc2)cc(C(C)(C)C)c1O 10.1021/jm0510530
44574078 185540 0 None -120 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 0 3 3.3 c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL468711 185540 0 None -120 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 0 3 3.3 c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
11372301 74330 0 None - 1 Rat 7.9 pEC50 = 7.9 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 376 7 1 7 1.9 O=S(=O)(c1ccccc1)c1c(OCCCc2ccc(O)cc2)no[n+]1[O-] 10.1021/jm0510530
CHEMBL189804 74330 0 None - 1 Rat 7.9 pEC50 = 7.9 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 376 7 1 7 1.9 O=S(=O)(c1ccccc1)c1c(OCCCc2ccc(O)cc2)no[n+]1[O-] 10.1021/jm0510530
10221081 130878 1 None 10 3 Rat 7.9 pEC50 = 7.9 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 270 4 0 6 0.5 CCOc1no[n+]([O-])c1S(=O)(=O)c1ccccc1 10.1021/jm0510530
CHEMBL363325 130878 1 None 10 3 Rat 7.9 pEC50 = 7.9 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 270 4 0 6 0.5 CCOc1no[n+]([O-])c1S(=O)(=O)c1ccccc1 10.1021/jm0510530
1960 9632 67 None 1 19 Rat 7.9 pEC50 = 7.9 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
439260 9632 67 None 1 19 Rat 7.9 pEC50 = 7.9 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
505 9632 67 None 1 19 Rat 7.9 pEC50 = 7.9 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
CHEMBL1437 9632 67 None 1 19 Rat 7.9 pEC50 = 7.9 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
DB00368 9632 67 None 1 19 Rat 7.9 pEC50 = 7.9 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
44362146 171713 1 None -50 3 Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 258 4 1 4 2.8 c1ccc(-c2ccsc2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL422477 171713 1 None -50 3 Human 7.9 pEC50 = 7.9 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 258 4 1 4 2.8 c1ccc(-c2ccsc2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
11645786 74061 0 None - 1 Rat 5.9 pEC50 = 5.9 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 339 7 1 6 3.0 Cc1c(C)c2c(c(C)c1O)CCC(C)(COCCCO[N+](=O)[O-])O2 10.1021/jm0510530
CHEMBL188200 74061 0 None - 1 Rat 5.9 pEC50 = 5.9 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 339 7 1 6 3.0 Cc1c(C)c2c(c(C)c1O)CCC(C)(COCCCO[N+](=O)[O-])O2 10.1021/jm0510530
44411100 83920 0 None - 1 Rat 5.9 pEC50 = 5.9 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 318 2 0 3 3.8 Cn1nc(Cc2ccc(Cl)cc2Cl)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL207779 83920 0 None - 1 Rat 5.9 pEC50 = 5.9 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 318 2 0 3 3.8 Cn1nc(Cc2ccc(Cl)cc2Cl)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
2765 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(02)00753-9
515 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(02)00753-9
CHEMBL13852 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(02)00753-9
DB09202 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(02)00753-9
2765 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00764-8
515 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00764-8
CHEMBL13852 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00764-8
DB09202 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00764-8
22493263 104860 0 None -100 3 Human 6.9 pEC50 = 6.9 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 270 5 2 6 1.4 CCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL273316 104860 0 None -100 3 Human 6.9 pEC50 = 6.9 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 270 5 2 6 1.4 CCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
2765 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00822-8
515 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00822-8
CHEMBL13852 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00822-8
DB09202 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00822-8
2765 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00569-8
515 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00569-8
CHEMBL13852 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00569-8
DB09202 7730 19 None -28 7 Human 6.9 pEC50 = 6.9 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 10.1016/s0960-894x(01)00569-8
44410832 84033 0 None - 1 Rat 6.9 pEC50 = 6.9 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 242 6 1 6 0.8 O=[N+]([O-])OCC(Cc1ccc(O)cc1)[N+](=O)[O-] 10.1021/jm0510530
CHEMBL207967 84033 0 None - 1 Rat 6.9 pEC50 = 6.9 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 242 6 1 6 0.8 O=[N+]([O-])OCC(Cc1ccc(O)cc1)[N+](=O)[O-] 10.1021/jm0510530
44411312 84526 0 None - 1 Rat 5.9 pEC50 = 5.9 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 298 3 0 3 3.7 CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL209043 84526 0 None - 1 Rat 5.9 pEC50 = 5.9 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 298 3 0 3 3.7 CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
44449692 163764 0 None -8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 251 2 1 3 3.1 c1cc(-c2ncco2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
CHEMBL407308 163764 0 None -8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 251 2 1 3 3.1 c1cc(-c2ncco2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
15959083 83781 0 None - 1 Rat 5.9 pEC50 = 5.9 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 284 2 0 3 3.2 Cn1nc(Cc2ccccc2Cl)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL207120 83781 0 None - 1 Rat 5.9 pEC50 = 5.9 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 284 2 0 3 3.2 Cn1nc(Cc2ccccc2Cl)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
15959085 145058 1 None - 1 Rat 4.9 pEC50 = 4.9 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 300 2 0 3 3.7 Cn1nc(Cc2cccc3ccccc23)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL377068 145058 1 None - 1 Rat 4.9 pEC50 = 4.9 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 300 2 0 3 3.7 Cn1nc(Cc2cccc3ccccc23)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
44574075 179355 0 None -72 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 251 2 0 4 2.9 c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL448802 179355 0 None -72 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 251 2 0 4 2.9 c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1 10.1016/j.bmcl.2009.03.166
44362208 42207 1 None -15 3 Human 7.8 pEC50 = 7.8 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 258 4 1 4 2.8 c1csc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL143801 42207 1 None -15 3 Human 7.8 pEC50 = 7.8 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 258 4 1 4 2.8 c1csc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
9816515 69752 0 None -5 3 Human 7.8 pEC50 = 7.8 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1ccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(03)00050-7
CHEMBL17856 69752 0 None -5 3 Human 7.8 pEC50 = 7.8 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1ccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(03)00050-7
44329133 214480 0 None -1 3 Human 7.8 pEC50 = 7.8 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 274 6 3 4 1.5 CC(C)CNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL95565 214480 0 None -1 3 Human 7.8 pEC50 = 7.8 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 274 6 3 4 1.5 CC(C)CNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
44329796 215158 0 None -1 3 Human 7.8 pEC50 = 7.8 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 7 2 5 2.1 CCCCOC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL99559 215158 0 None -1 3 Human 7.8 pEC50 = 7.8 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 7 2 5 2.1 CCCCOC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
11502000 146968 0 None - 1 Rat 5.8 pEC50 = 5.8 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 390 5 2 7 1.3 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN(C)Cc1no[n+]([O-])c1C(N)=O)O2 10.1021/jm0510530
CHEMBL380475 146968 0 None - 1 Rat 5.8 pEC50 = 5.8 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 390 5 2 7 1.3 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN(C)Cc1no[n+]([O-])c1C(N)=O)O2 10.1021/jm0510530
2146 9874 67 None -17 15 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
485 9874 67 None -17 15 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
6041 9874 67 None -17 15 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
CHEMBL1215 9874 67 None -17 15 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
DB00388 9874 67 None -17 15 Rat 6.8 pEC50 = 6.8 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
9795167 114271 0 None -6 3 Human 6.8 pEC50 = 6.8 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 260 6 3 4 1.2 CCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL318544 114271 0 None -6 3 Human 6.8 pEC50 = 6.8 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 260 6 3 4 1.2 CCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
44362185 127807 0 None -19 3 Human 6.8 pEC50 = 6.8 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 253 4 1 4 2.1 c1cncc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL356605 127807 0 None -19 3 Human 6.8 pEC50 = 6.8 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 253 4 1 4 2.1 c1cncc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
9795167 114271 0 None -6 3 Human 6.8 pEC50 = 6.8 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 6 3 4 1.2 CCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL318544 114271 0 None -6 3 Human 6.8 pEC50 = 6.8 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 6 3 4 1.2 CCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
22493318 51531 0 None -34 3 Human 7.8 pEC50 = 7.8 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 241 4 2 4 2.4 c1coc(-c2ccccc2NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL152155 51531 0 None -34 3 Human 7.8 pEC50 = 7.8 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 241 4 2 4 2.4 c1coc(-c2ccccc2NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
44369351 126380 0 None -8 3 Human 7.7 pEC50 = 7.7 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 257 4 2 4 2.8 c1csc(-c2ccccc2NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL346380 126380 0 None -8 3 Human 7.7 pEC50 = 7.7 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 257 4 2 4 2.8 c1csc(-c2ccccc2NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
9816460 126671 0 None -39 3 Human 6.7 pEC50 = 6.7 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 253 4 2 5 1.6 c1ccc(-c2cnccn2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL349082 126671 0 None -39 3 Human 6.7 pEC50 = 6.7 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 253 4 2 5 1.6 c1ccc(-c2cnccn2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
44343410 18327 2 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 219 4 2 3 2.7 CSc1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
CHEMBL118055 18327 2 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 219 4 2 3 2.7 CSc1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
22493365 105240 0 None -15 3 Human 7.7 pEC50 = 7.7 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cn[nH]c2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
CHEMBL275844 105240 0 None -15 3 Human 7.7 pEC50 = 7.7 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cn[nH]c2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
22493258 105440 0 None -5 3 Human 7.7 pEC50 = 7.7 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
CHEMBL277375 105440 0 None -5 3 Human 7.7 pEC50 = 7.7 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
15959081 145675 6 None - 1 Rat 5.7 pEC50 = 5.7 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 270 2 1 3 3.6 Oc1nnc(Cc2ccccc2Cl)c2ccccc12 10.1016/j.bmcl.2006.02.003
CHEMBL378274 145675 6 None - 1 Rat 5.7 pEC50 = 5.7 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 270 2 1 3 3.6 Oc1nnc(Cc2ccccc2Cl)c2ccccc12 10.1016/j.bmcl.2006.02.003
11502000 146968 0 None - 1 Rat 4.7 pEC50 = 4.7 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 390 5 2 7 1.3 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN(C)Cc1no[n+]([O-])c1C(N)=O)O2 10.1021/jm0510530
CHEMBL380475 146968 0 None - 1 Rat 4.7 pEC50 = 4.7 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 390 5 2 7 1.3 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN(C)Cc1no[n+]([O-])c1C(N)=O)O2 10.1021/jm0510530
44271932 71985 0 None -31 3 Human 6.7 pEC50 = 6.7 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1ccnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL18256 71985 0 None -31 3 Human 6.7 pEC50 = 6.7 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1ccnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
22493320 10976 0 None -10 3 Human 6.7 pEC50 = 6.7 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 246 4 2 4 0.8 CN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL100198 10976 0 None -10 3 Human 6.7 pEC50 = 6.7 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 246 4 2 4 0.8 CN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
11109088 210959 0 None -6 5 Human 8.6 pEC50 = 8.6 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70751 210959 0 None -6 5 Human 8.6 pEC50 = 8.6 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
22493280 55049 0 None -1 3 Human 8.5 pEC50 = 8.5 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ccno2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL155327 55049 0 None -1 3 Human 8.5 pEC50 = 8.5 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ccno2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
11140347 211312 1 None -11 5 Human 7.7 pEC50 = 7.7 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72768 211312 1 None -11 5 Human 7.7 pEC50 = 7.7 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
11669259 84113 0 None - 1 Rat 7.7 pEC50 = 7.7 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 436 9 1 9 1.9 COc1cc(CCCOc2no[n+]([O-])c2S(=O)(=O)c2ccccc2)cc(OC)c1O 10.1021/jm0510530
CHEMBL208390 84113 0 None - 1 Rat 7.7 pEC50 = 7.7 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 436 9 1 9 1.9 COc1cc(CCCOc2no[n+]([O-])c2S(=O)(=O)c2ccccc2)cc(OC)c1O 10.1021/jm0510530
15959115 210404 0 None - 1 Rat 5.7 pEC50 = 5.7 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 310 4 0 5 2.5 COc1ccc(Cc2nn(C)c(=O)c3ccccc23)cc1OC 10.1016/j.bmcl.2006.02.003
CHEMBL67126 210404 0 None - 1 Rat 5.7 pEC50 = 5.7 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 310 4 0 5 2.5 COc1ccc(Cc2nn(C)c(=O)c3ccccc23)cc1OC 10.1016/j.bmcl.2006.02.003
22933 83488 17 None - 1 Rat 6.6 pEC50 = 6.6 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 166 5 0 6 -0.2 CC(CO[N+](=O)[O-])O[N+](=O)[O-] 10.1021/jm0510530
CHEMBL206527 83488 17 None - 1 Rat 6.6 pEC50 = 6.6 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 166 5 0 6 -0.2 CC(CO[N+](=O)[O-])O[N+](=O)[O-] 10.1021/jm0510530
44362149 40706 0 None -5 3 Human 7.6 pEC50 = 7.6 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 259 4 1 5 2.2 c1ccc(-c2ccns2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL142387 40706 0 None -5 3 Human 7.6 pEC50 = 7.6 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 259 4 1 5 2.2 c1ccc(-c2ccns2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
9859855 67171 0 None -12 2 Human 6.6 pEC50 = 6.6 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 254 4 2 4 2.1 Cn1cccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL17492 67171 0 None -12 2 Human 6.6 pEC50 = 6.6 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 254 4 2 4 2.1 Cn1cccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
22493265 68908 0 None -19 3 Human 6.6 pEC50 = 6.6 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 284 6 2 6 1.8 CCCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL17776 68908 0 None -19 3 Human 6.6 pEC50 = 6.6 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 284 6 2 6 1.8 CCCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
44329701 214457 0 None -3 3 Human 6.6 pEC50 = 6.6 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 6 2 5 1.9 CC(C)COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL95398 214457 0 None -3 3 Human 6.6 pEC50 = 6.6 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 275 6 2 5 1.9 CC(C)COC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
4038180 6992 14 None -457 6 Rat 5.6 pEC50 = 5.6 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
480 6992 14 None -457 6 Rat 5.6 pEC50 = 5.6 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
CHEMBL109783 6992 14 None -457 6 Rat 5.6 pEC50 = 5.6 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
15959119 83831 0 None 1 2 Rat 5.6 pEC50 = 5.6 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 310 4 0 3 3.8 C=CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL207277 83831 0 None 1 2 Rat 5.6 pEC50 = 5.6 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 310 4 0 3 3.8 C=CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
44574134 185283 0 None -91 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 269 2 0 4 3.0 Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL466634 185283 0 None -91 3 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 269 2 0 4 3.0 Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1 10.1016/j.bmcl.2009.03.166
44574135 195957 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 1 3 2.8 Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL511211 195957 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 268 2 1 3 2.8 Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1 10.1016/j.bmcl.2009.03.166
22493415 56747 0 None 1 2 Human 7.5 pEC50 = 7.5 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 268 4 3 6 1.1 Nc1nccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(01)00822-8
CHEMBL156893 56747 0 None 1 2 Human 7.5 pEC50 = 7.5 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 268 4 3 6 1.1 Nc1nccc(-c2ccccc2NCC2=NCCN2)n1 10.1016/s0960-894x(01)00822-8
15959112 210311 0 None 1 2 Rat 5.5 pEC50 = 5.5 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 280 2 1 5 2.7 Oc1nnc(Cc2ccc3c(c2)OCO3)c2ccccc12 10.1016/j.bmcl.2006.02.003
CHEMBL66433 210311 0 None 1 2 Rat 5.5 pEC50 = 5.5 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 280 2 1 5 2.7 Oc1nnc(Cc2ccc3c(c2)OCO3)c2ccccc12 10.1016/j.bmcl.2006.02.003
15959093 84103 1 None - 1 Rat 4.5 pEC50 = 4.5 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 391 4 0 5 4.5 O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1-c1ccc([N+](=O)[O-])cc1 10.1016/j.bmcl.2006.02.003
CHEMBL208355 84103 1 None - 1 Rat 4.5 pEC50 = 4.5 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 391 4 0 5 4.5 O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1-c1ccc([N+](=O)[O-])cc1 10.1016/j.bmcl.2006.02.003
22493236 67170 0 None -5 3 Human 8.4 pEC50 = 8.4 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 242 4 3 5 0.9 c1ccc(-c2nc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
CHEMBL17491 67170 0 None -5 3 Human 8.4 pEC50 = 8.4 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 242 4 3 5 0.9 c1ccc(-c2nc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
44574986 195989 0 None -7 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 202 1 0 2 2.4 Fc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
CHEMBL511411 195989 0 None -7 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 202 1 0 2 2.4 Fc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
44343244 16724 0 None -5 2 Human 7.5 pEC50 = 7.5 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 241 3 3 4 2.0 Oc1ccc2cccc(NCC3=NCCN3)c2c1 10.1016/s0960-894x(02)00753-9
CHEMBL114669 16724 0 None -5 2 Human 7.5 pEC50 = 7.5 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 241 3 3 4 2.0 Oc1ccc2cccc(NCC3=NCCN3)c2c1 10.1016/s0960-894x(02)00753-9
44362196 41262 1 None -12 3 Human 7.5 pEC50 = 7.5 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 259 4 1 5 2.2 c1ccc(-c2nccs2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL142871 41262 1 None -12 3 Human 7.5 pEC50 = 7.5 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 259 4 1 5 2.2 c1ccc(-c2nccs2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
44410820 83857 0 None - 1 Rat 5.5 pEC50 = 5.5 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 186 3 1 5 -1.5 CN(C)Cc1no[n+]([O-])c1C(N)=O 10.1021/jm0510530
CHEMBL207437 83857 0 None - 1 Rat 5.5 pEC50 = 5.5 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 186 3 1 5 -1.5 CN(C)Cc1no[n+]([O-])c1C(N)=O 10.1021/jm0510530
22493379 214905 0 None -6 3 Human 6.5 pEC50 = 6.5 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 5 3 4 1.2 CC(C)NC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL98016 214905 0 None -6 3 Human 6.5 pEC50 = 6.5 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 5 3 4 1.2 CC(C)NC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
9903932 66284 0 None -501 2 Human 5.5 pEC50 = 5.5 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 284 5 2 6 1.9 CC(C)n1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL17151 66284 0 None -501 2 Human 5.5 pEC50 = 5.5 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 284 5 2 6 1.9 CC(C)n1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
44449730 162887 0 None -22 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 2 2 2.9 c1cc(-c2cn[nH]c2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
CHEMBL406316 162887 0 None -22 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 2 2 2.9 c1cc(-c2cn[nH]c2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
44449686 102859 0 None -7 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 267 2 1 3 3.6 c1cc(-c2nccs2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
CHEMBL260116 102859 0 None -7 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 267 2 1 3 3.6 c1cc(-c2nccs2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
11140345 210950 0 None -4 5 Human 7.5 pEC50 = 7.5 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 239 4 2 4 2.0 CSc1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70692 210950 0 None -4 5 Human 7.5 pEC50 = 7.5 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 239 4 2 4 2.0 CSc1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
44410938 147461 0 None - 1 Rat 5.5 pEC50 = 5.5 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 354 6 1 6 3.4 CC(C)(C)c1cc(CC(CO[N+](=O)[O-])[N+](=O)[O-])cc(C(C)(C)C)c1O 10.1021/jm0510530
CHEMBL381519 147461 0 None - 1 Rat 5.5 pEC50 = 5.5 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 354 6 1 6 3.4 CC(C)(C)c1cc(CC(CO[N+](=O)[O-])[N+](=O)[O-])cc(C(C)(C)C)c1O 10.1021/jm0510530
44449245 102188 0 None -6 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 2 2 2.9 c1cc(-c2ccn[nH]2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
CHEMBL256983 102188 0 None -6 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 250 2 2 2 2.9 c1cc(-c2ccn[nH]2)c2c(c1)C(c1ncc[nH]1)CC2 10.1016/j.bmcl.2008.03.070
44574877 185320 0 None -23 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 228 2 1 2 2.7 COc1ccccc1C1CCc2nc[nH]c2C1 10.1016/j.bmcl.2009.03.162
CHEMBL466869 185320 0 None -23 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 228 2 1 2 2.7 COc1ccccc1C1CCc2nc[nH]c2C1 10.1016/j.bmcl.2009.03.162
11372301 74330 0 None - 1 Rat 6.4 pEC50 = 6.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 376 7 1 7 1.9 O=S(=O)(c1ccccc1)c1c(OCCCc2ccc(O)cc2)no[n+]1[O-] 10.1021/jm0510530
CHEMBL189804 74330 0 None - 1 Rat 6.4 pEC50 = 6.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 376 7 1 7 1.9 O=S(=O)(c1ccccc1)c1c(OCCCc2ccc(O)cc2)no[n+]1[O-] 10.1021/jm0510530
17804479 102435 19 None 1 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.9 c1ccc2c(c1)CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL258007 102435 19 None 1 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 198 1 1 1 2.9 c1ccc2c(c1)CCCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44574935 179401 0 None -19 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 218 1 0 2 2.9 Clc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
CHEMBL449284 179401 0 None -19 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 218 1 0 2 2.9 Clc1ccccc1C1Cc2nccn2C1 10.1016/j.bmcl.2009.03.162
749966 210565 21 None 2 2 Rat 5.4 pEC50 = 5.4 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 296 4 1 5 2.9 COc1ccc(Cc2nnc(O)c3ccccc23)cc1OC 10.1016/j.bmcl.2006.02.003
CHEMBL68230 210565 21 None 2 2 Rat 5.4 pEC50 = 5.4 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 296 4 1 5 2.9 COc1ccc(Cc2nnc(O)c3ccccc23)cc1OC 10.1016/j.bmcl.2006.02.003
44574074 196248 0 None -977 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 262 2 0 4 2.7 c1ccc([C@@H]2Cc3nccn3C2)c(-c2cncnc2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL513691 196248 0 None -977 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 262 2 0 4 2.7 c1ccc([C@@H]2Cc3nccn3C2)c(-c2cncnc2)c1 10.1016/j.bmcl.2009.03.166
22493367 72959 0 None -1 3 Human 6.4 pEC50 = 6.4 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 298 7 2 6 2.2 CCCCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL18436 72959 0 None -1 3 Human 6.4 pEC50 = 6.4 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 298 7 2 6 2.2 CCCCn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
22493231 214444 0 None -5 3 Human 6.4 pEC50 = 6.4 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 286 4 2 4 1.7 O=C(c1ccccc1NCC1=NCCN1)N1CCCCC1 10.1016/s0960-894x(01)00569-8
CHEMBL95333 214444 0 None -5 3 Human 6.4 pEC50 = 6.4 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 286 4 2 4 1.7 O=C(c1ccccc1NCC1=NCCN1)N1CCCCC1 10.1016/s0960-894x(01)00569-8
11507836 74003 0 None - 1 Rat 4.4 pEC50 = 4.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 309 5 1 4 4.1 CC(C)(C)c1cc(CCCO[N+](=O)[O-])cc(C(C)(C)C)c1O 10.1021/jm0510530
CHEMBL187933 74003 0 None - 1 Rat 4.4 pEC50 = 4.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 309 5 1 4 4.1 CC(C)(C)c1cc(CCCO[N+](=O)[O-])cc(C(C)(C)C)c1O 10.1021/jm0510530
22493392 53929 0 None -3 3 Human 7.4 pEC50 = 7.4 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 252 4 2 4 2.2 c1ccc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
CHEMBL154298 53929 0 None -3 3 Human 7.4 pEC50 = 7.4 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 252 4 2 4 2.2 c1ccc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
11604114 83860 0 None - 1 Rat 6.4 pEC50 = 6.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 418 7 2 6 2.8 CN(CCCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Cc1no[n+]([O-])c1C(N)=O 10.1021/jm0510530
CHEMBL207448 83860 0 None - 1 Rat 6.4 pEC50 = 6.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 418 7 2 6 2.8 CN(CCCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Cc1no[n+]([O-])c1C(N)=O 10.1021/jm0510530
12307 74121 37 None - 1 Rat 4.4 pEC50 = 4.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 105 3 0 3 0.6 CCCO[N+](=O)[O-] 10.1021/jm0510530
CHEMBL188554 74121 37 None - 1 Rat 4.4 pEC50 = 4.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 105 3 0 3 0.6 CCCO[N+](=O)[O-] 10.1021/jm0510530
11034737 211307 0 None -7 4 Human 7.4 pEC50 = 7.4 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 289 4 2 4 2.8 CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72724 211307 0 None -7 4 Human 7.4 pEC50 = 7.4 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 289 4 2 4 2.8 CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
11522042 210458 1 None 1 2 Rat 6.4 pEC50 = 6.4 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 284 2 0 3 3.2 Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL67457 210458 1 None 1 2 Rat 6.4 pEC50 = 6.4 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 284 2 0 3 3.2 Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
11615834 83814 0 None - 1 Rat 5.4 pEC50 = 5.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 257 7 1 6 1.6 COc1cc(CCCO[N+](=O)[O-])cc(OC)c1O 10.1021/jm0510530
CHEMBL207183 83814 0 None - 1 Rat 5.4 pEC50 = 5.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 257 7 1 6 1.6 COc1cc(CCCO[N+](=O)[O-])cc(OC)c1O 10.1021/jm0510530
11397014 129680 0 None - 1 Rat 7.4 pEC50 = 7.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 460 5 1 8 2.9 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1no[n+]([O-])c1S(=O)(=O)c1ccccc1)O2 10.1021/jm0510530
CHEMBL360593 129680 0 None - 1 Rat 7.4 pEC50 = 7.4 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 460 5 1 8 2.9 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1no[n+]([O-])c1S(=O)(=O)c1ccccc1)O2 10.1021/jm0510530
13190952 83815 5 None - 1 Rat 5.4 pEC50 = 5.4 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 286 2 1 3 4.1 Oc1nnc(Cc2cccc3ccccc23)c2ccccc12 10.1016/j.bmcl.2006.02.003
CHEMBL207189 83815 5 None - 1 Rat 5.4 pEC50 = 5.4 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 286 2 1 3 4.1 Oc1nnc(Cc2cccc3ccccc23)c2ccccc12 10.1016/j.bmcl.2006.02.003
44369431 52129 0 None -57 3 Human 7.3 pEC50 = 7.3 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 271 4 2 4 3.1 Cc1ccsc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL152693 52129 0 None -57 3 Human 7.3 pEC50 = 7.3 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 271 4 2 4 3.1 Cc1ccsc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
11684556 73979 0 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 488 7 1 7 4.5 CC(C)(C)c1cc(CCCOc2no[n+]([O-])c2S(=O)(=O)c2ccccc2)cc(C(C)(C)C)c1O 10.1021/jm0510530
CHEMBL187824 73979 0 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 488 7 1 7 4.5 CC(C)(C)c1cc(CCCOc2no[n+]([O-])c2S(=O)(=O)c2ccccc2)cc(C(C)(C)C)c1O 10.1021/jm0510530
15959114 82349 0 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 318 2 0 3 3.8 Cn1nc(Cc2ccc(Cl)c(Cl)c2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL204632 82349 0 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 318 2 0 3 3.8 Cn1nc(Cc2ccc(Cl)c(Cl)c2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
44410833 147319 0 None - 1 Rat 4.3 pEC50 = 4.3 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 302 8 1 8 0.8 COc1cc(CC(CO[N+](=O)[O-])[N+](=O)[O-])cc(OC)c1O 10.1021/jm0510530
CHEMBL381054 147319 0 None - 1 Rat 4.3 pEC50 = 4.3 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 302 8 1 8 0.8 COc1cc(CC(CO[N+](=O)[O-])[N+](=O)[O-])cc(OC)c1O 10.1021/jm0510530
44362194 41156 1 None -10 3 Human 8.3 pEC50 = 8.3 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 1 4 2.3 c1ccc(-c2ccoc2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL142784 41156 1 None -10 3 Human 8.3 pEC50 = 8.3 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 242 4 1 4 2.3 c1ccc(-c2ccoc2)c(OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
11098175 210949 0 None -3 4 Human 8.3 pEC50 = 8.3 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 251 5 2 5 1.8 COc1ccc(SC)c(NCC2=NCCN2)c1 10.1021/jm000542r
CHEMBL70691 210949 0 None -3 4 Human 8.3 pEC50 = 8.3 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 251 5 2 5 1.8 COc1ccc(SC)c(NCC2=NCCN2)c1 10.1021/jm000542r
22493352 55048 0 None -2 3 Human 8.3 pEC50 = 8.3 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ncco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL155326 55048 0 None -2 3 Human 8.3 pEC50 = 8.3 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ncco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
11669259 84113 0 None - 1 Rat 6.3 pEC50 = 6.3 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 436 9 1 9 1.9 COc1cc(CCCOc2no[n+]([O-])c2S(=O)(=O)c2ccccc2)cc(OC)c1O 10.1021/jm0510530
CHEMBL208390 84113 0 None - 1 Rat 6.3 pEC50 = 6.3 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 436 9 1 9 1.9 COc1cc(CCCOc2no[n+]([O-])c2S(=O)(=O)c2ccccc2)cc(OC)c1O 10.1021/jm0510530
11000184 19824 0 None -15 5 Human 7.3 pEC50 = 7.3 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1190038 19824 0 None -15 5 Human 7.3 pEC50 = 7.3 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL540035 19824 0 None -15 5 Human 7.3 pEC50 = 7.3 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
15959118 83844 0 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 324 5 0 5 3.0 CCn1nc(Cc2ccc(OC)c(OC)c2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL207325 83844 0 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 324 5 0 5 3.0 CCn1nc(Cc2ccc(OC)c(OC)c2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
15959089 146104 1 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 352 7 0 5 3.8 CCCCn1nc(Cc2ccc(OC)c(OC)c2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL379270 146104 1 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 352 7 0 5 3.8 CCCCn1nc(Cc2ccc(OC)c(OC)c2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
15959111 144940 2 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 282 3 1 4 3.6 CSc1ccc(Cc2nnc(O)c3ccccc23)cc1 10.1016/j.bmcl.2006.02.003
CHEMBL376932 144940 2 None - 1 Rat 5.3 pEC50 = 5.3 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 282 3 1 4 3.6 CSc1ccc(Cc2nnc(O)c3ccccc23)cc1 10.1016/j.bmcl.2006.02.003
44362195 127867 0 None -2 3 Human 8.2 pEC50 = 8.2 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 241 4 2 3 2.1 c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL357129 127867 0 None -2 3 Human 8.2 pEC50 = 8.2 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 241 4 2 3 2.1 c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
22493343 70745 0 None -31 3 Human 7.2 pEC50 = 7.2 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 256 4 2 6 0.9 Cn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL18069 70745 0 None -31 3 Human 7.2 pEC50 = 7.2 Functional
Agonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsAgonism of recombinant human alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 256 4 2 6 0.9 Cn1ncnc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
44329790 119323 0 None -5 3 Human 7.2 pEC50 = 7.2 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 247 5 2 5 1.3 CCOC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL329928 119323 0 None -5 3 Human 7.2 pEC50 = 7.2 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 247 5 2 5 1.3 CCOC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
9903313 179457 0 None -6 3 Human 6.2 pEC50 = 6.2 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 5 2 4 1.2 CCN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL450018 179457 0 None -6 3 Human 6.2 pEC50 = 6.2 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 260 5 2 4 1.2 CCN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
10103414 83312 15 None 1 3 Rat 5.2 pEC50 = 5.2 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 159 2 2 5 -2.1 NC(=O)c1c(CO)no[n+]1[O-] 10.1021/jm0510530
CHEMBL206100 83312 15 None 1 3 Rat 5.2 pEC50 = 5.2 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 159 2 2 5 -2.1 NC(=O)c1c(CO)no[n+]1[O-] 10.1021/jm0510530
44449725 102965 0 None -208 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 264 2 2 2 3.2 Cc1n[nH]cc1-c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
CHEMBL260720 102965 0 None -208 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 264 2 2 2 3.2 Cc1n[nH]cc1-c1cccc2c1CCC2c1ncc[nH]1 10.1016/j.bmcl.2008.03.070
44410833 147319 0 None - 1 Rat 6.2 pEC50 = 6.2 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 302 8 1 8 0.8 COc1cc(CC(CO[N+](=O)[O-])[N+](=O)[O-])cc(OC)c1O 10.1021/jm0510530
CHEMBL381054 147319 0 None - 1 Rat 6.2 pEC50 = 6.2 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips
ChEMBL 302 8 1 8 0.8 COc1cc(CC(CO[N+](=O)[O-])[N+](=O)[O-])cc(OC)c1O 10.1021/jm0510530
44410832 84033 0 None - 1 Rat 4.2 pEC50 = 4.2 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 242 6 1 6 0.8 O=[N+]([O-])OCC(Cc1ccc(O)cc1)[N+](=O)[O-] 10.1021/jm0510530
CHEMBL207967 84033 0 None - 1 Rat 4.2 pEC50 = 4.2 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 242 6 1 6 0.8 O=[N+]([O-])OCC(Cc1ccc(O)cc1)[N+](=O)[O-] 10.1021/jm0510530
44574079 196088 0 None -8 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 0 3 3.3 c1ccc([C@@H]2Cc3nccn3C2)c(-c2ccncc2)c1 10.1016/j.bmcl.2009.03.166
CHEMBL512289 196088 0 None -8 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 261 2 0 3 3.3 c1ccc([C@@H]2Cc3nccn3C2)c(-c2ccncc2)c1 10.1016/j.bmcl.2009.03.166
11397014 129680 0 None - 1 Rat 6.2 pEC50 = 6.2 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 460 5 1 8 2.9 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1no[n+]([O-])c1S(=O)(=O)c1ccccc1)O2 10.1021/jm0510530
CHEMBL360593 129680 0 None - 1 Rat 6.2 pEC50 = 6.2 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 460 5 1 8 2.9 Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1no[n+]([O-])c1S(=O)(=O)c1ccccc1)O2 10.1021/jm0510530
11108001 17644 2 None -1 5 Human 8.1 pEC50 = 8.1 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL117248 17644 2 None -1 5 Human 8.1 pEC50 = 8.1 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL540542 17644 2 None -1 5 Human 8.1 pEC50 = 8.1 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
44574045 196065 0 None -60 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 260 2 0 2 3.9 c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1 10.1016/j.bmcl.2009.03.166
CHEMBL512062 196065 0 None -60 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 260 2 0 2 3.9 c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1 10.1016/j.bmcl.2009.03.166
12764879 185202 0 None -100 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 184 1 0 2 2.2 c1ccc(C2Cc3nccn3C2)cc1 10.1016/j.bmcl.2009.03.162
CHEMBL465963 185202 0 None -100 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
ChEMBL 184 1 0 2 2.2 c1ccc(C2Cc3nccn3C2)cc1 10.1016/j.bmcl.2009.03.162
11604114 83860 0 None - 1 Rat 5.1 pEC50 = 5.1 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 418 7 2 6 2.8 CN(CCCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Cc1no[n+]([O-])c1C(N)=O 10.1021/jm0510530
CHEMBL207448 83860 0 None - 1 Rat 5.1 pEC50 = 5.1 Functional
Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQVasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQ
ChEMBL 418 7 2 6 2.8 CN(CCCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Cc1no[n+]([O-])c1C(N)=O 10.1021/jm0510530
44343247 117412 0 None -15 3 Human 7.1 pEC50 = 7.1 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 258 6 3 3 2.2 CCCNC(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
CHEMBL325745 117412 0 None -15 3 Human 7.1 pEC50 = 7.1 Functional
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblastsActivation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
ChEMBL 258 6 3 3 2.2 CCCNC(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
22493224 215124 4 None -6 3 Human 7.1 pEC50 = 7.1 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 246 5 3 4 0.9 CCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL99362 215124 4 None -6 3 Human 7.1 pEC50 = 7.1 Functional
Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.Potency against cloned human alpha 1D-adrenoceptor expressed in rat-1 fibroblasts.
ChEMBL 246 5 3 4 0.9 CCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
104452 209880 73 None 4 2 Rat 6.1 pEC50 = 6.1 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 270 2 1 3 3.6 Oc1nnc(Cc2ccc(Cl)cc2)c2ccccc12 10.1016/j.bmcl.2006.02.003
CHEMBL63976 209880 73 None 4 2 Rat 6.1 pEC50 = 6.1 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 270 2 1 3 3.6 Oc1nnc(Cc2ccc(Cl)cc2)c2ccccc12 10.1016/j.bmcl.2006.02.003
44352155 123586 0 None -100 5 Human 6.1 pEC50 = 6.1 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 251 4 2 3 2.8 c1ccc(-c2ccccc2NCC2=NCCN2)cc1 10.1016/s0960-894x(01)00764-8
CHEMBL337862 123586 0 None -100 5 Human 6.1 pEC50 = 6.1 Functional
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC pathway
ChEMBL 251 4 2 3 2.8 c1ccc(-c2ccccc2NCC2=NCCN2)cc1 10.1016/s0960-894x(01)00764-8
11108001 17644 2 None -1 5 Human 8.1 pEC50 = 8.1 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblastsAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL117248 17644 2 None -1 5 Human 8.1 pEC50 = 8.1 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblastsAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL540542 17644 2 None -1 5 Human 8.1 pEC50 = 8.1 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblastsAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
22493289 56462 0 None -4 3 Human 7.1 pEC50 = 7.1 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 253 4 2 5 1.6 c1cnc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
CHEMBL156661 56462 0 None -4 3 Human 7.1 pEC50 = 7.1 Functional
In vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1D receptor expressed in rat-1 fibroblasts via calcium using mobilization through the Gq coupled PLC pathway as functional assay
ChEMBL 253 4 2 5 1.6 c1cnc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
124 9755 47 None -4168 25 Rat 5.1 pEC50 = 5.1 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
2032 9755 47 None -4168 25 Rat 5.1 pEC50 = 5.1 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
4636 9755 47 None -4168 25 Rat 5.1 pEC50 = 5.1 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
CHEMBL762 9755 47 None -4168 25 Rat 5.1 pEC50 = 5.1 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
DB00935 9755 47 None -4168 25 Rat 5.1 pEC50 = 5.1 Functional
In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaIn vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
11097789 109775 1 None -1 5 Human 8.0 pEC50 = 8.0 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 239 4 2 4 2.0 CSc1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL306792 109775 1 None -1 5 Human 8.0 pEC50 = 8.0 Functional
Agonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptorAgonist potency at Alpha-1D adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1D adrenergic receptor
ChEMBL 239 4 2 4 2.0 CSc1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
44411120 83313 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 296 3 0 4 3.2 CSc1ccc(Cc2nn(C)c(=O)c3ccccc23)cc1 10.1016/j.bmcl.2006.02.003
CHEMBL206101 83313 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 296 3 0 4 3.2 CSc1ccc(Cc2nn(C)c(=O)c3ccccc23)cc1 10.1016/j.bmcl.2006.02.003
15959084 210587 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 294 2 0 5 2.3 Cn1nc(Cc2ccc3c(c2)OCO3)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL68362 210587 0 None - 1 Rat 6.0 pEC50 = 6.0 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 294 2 0 5 2.3 Cn1nc(Cc2ccc3c(c2)OCO3)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
15959121 83807 0 None - 1 Rat 5.0 pEC50 = 5.0 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 336 6 0 5 3.2 C=CCn1nc(Cc2ccc(OC)c(OC)c2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
CHEMBL207170 83807 0 None - 1 Rat 5.0 pEC50 = 5.0 Functional
Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionVasorelaxation of phenylephrine-stimulated Wistar rat aorta contraction
ChEMBL 336 6 0 5 3.2 C=CCn1nc(Cc2ccc(OC)c(OC)c2)c2ccccc2c1=O 10.1016/j.bmcl.2006.02.003
127044912 147206 0 None 26 3 Human 10.0 pIC50 = 10 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 501 14 3 6 4.3 CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCc1ccccc1 10.1021/acs.jmedchem.5b02023
CHEMBL3809093 147206 0 None 26 3 Human 10.0 pIC50 = 10 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 501 14 3 6 4.3 CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCc1ccccc1 10.1021/acs.jmedchem.5b02023
129211 10521 78 None 1 14 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2020.112616
2562 10521 78 None 1 14 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2020.112616
488 10521 78 None 1 14 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2020.112616
CHEMBL836 10521 78 None 1 14 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2020.112616
DB00706 10521 78 None 1 14 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2020.112616
123667086 147177 0 None 8 3 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 573 13 3 6 3.8 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Br)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
CHEMBL3808726 147177 0 None 8 3 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 573 13 3 6 3.8 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Br)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
124018870 147189 0 None 7 3 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 445 12 3 6 2.3 COc1ccc(F)cc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
CHEMBL3808896 147189 0 None 7 3 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 445 12 3 6 2.3 COc1ccc(F)cc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
123387804 147199 0 None 52 3 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 423 12 3 5 3.3 CCc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3808999 147199 0 None 52 3 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 423 12 3 5 3.3 CCc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
127044911 147226 0 None 10 3 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 425 12 3 6 2.7 COc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3809319 147226 0 None 10 3 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 425 12 3 6 2.7 COc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
123562321 147289 0 None -1 3 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 443 12 3 6 2.9 COc1ccc(F)cc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3810110 147289 0 None -1 3 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 443 12 3 6 2.9 COc1ccc(F)cc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
129211 10521 78 None 1 14 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.6b01217
2562 10521 78 None 1 14 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.6b01217
488 10521 78 None 1 14 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.6b01217
CHEMBL836 10521 78 None 1 14 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.6b01217
DB00706 10521 78 None 1 14 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.6b01217
127045050 147171 0 None 5 3 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 503 14 3 6 3.7 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCc1ccccc1 10.1021/acs.jmedchem.5b02023
CHEMBL3808632 147171 0 None 5 3 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 503 14 3 6 3.7 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCc1ccccc1 10.1021/acs.jmedchem.5b02023
127044916 147260 0 None -1 3 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 443 12 3 6 2.9 COc1cc(F)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3809676 147260 0 None -1 3 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 443 12 3 6 2.9 COc1cc(F)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
145946682 174353 0 None 10 3 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 444 7 0 3 5.6 Fc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1 10.1016/j.bmcl.2018.03.070
CHEMBL4225239 174353 0 None 10 3 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 444 7 0 3 5.6 Fc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1 10.1016/j.bmcl.2018.03.070
CHEMBL4300633 174353 0 None 10 3 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 444 7 0 3 5.6 Fc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1 10.1016/j.bmcl.2018.03.070
11536337 79386 1 None - 1 Rat 5.0 pIC50 = 5.0 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 270 1 3 5 2.6 O=c1oc2ccc(O)cc2cc1-c1cc(O)cc(O)c1 10.1016/j.bmcl.2005.10.013
CHEMBL199397 79386 1 None - 1 Rat 5.0 pIC50 = 5.0 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 270 1 3 5 2.6 O=c1oc2ccc(O)cc2cc1-c1cc(O)cc(O)c1 10.1016/j.bmcl.2005.10.013
117839022 147309 0 None -407 3 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 529 13 3 6 3.7 C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
CHEMBL3810346 147309 0 None -407 3 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 529 13 3 6 3.7 C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
9891967 114302 34 None -4 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 495 13 3 6 3.1 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
CHEMBL3187195 114302 34 None -4 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 495 13 3 6 3.1 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
123472560 147272 0 None -616 3 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 507 13 3 6 4.0 Cc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3809840 147272 0 None -616 3 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 507 13 3 6 4.0 Cc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1 10.1021/acs.jmedchem.5b02023
123688273 147259 0 None -36 3 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 513 13 3 6 3.2 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc(F)cc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
CHEMBL3809630 147259 0 None -36 3 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 513 13 3 6 3.2 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc(F)cc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
134147190 156577 0 None -3 3 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 334 0 2 4 3.3 Oc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4 10.1021/acs.jmedchem.6b01217
CHEMBL3948551 156577 0 None -3 3 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 334 0 2 4 3.3 Oc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4 10.1021/acs.jmedchem.6b01217
127044894 147145 0 None -3 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 427 12 3 6 2.1 COc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
CHEMBL3808408 147145 0 None -3 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 427 12 3 6 2.1 COc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
9913616 147161 6 None -8 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 493 13 3 6 3.7 CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
CHEMBL3808572 147161 6 None -8 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 493 13 3 6 3.7 CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
123752717 147248 0 None -26 3 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 439 11 3 5 3.1 Cc1cc(C)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c(C)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3809500 147248 0 None -26 3 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 439 11 3 5 3.1 Cc1cc(C)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c(C)c1 10.1021/acs.jmedchem.5b02023
123475619 147269 0 None -43 3 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 503 12 3 6 3.5 COc1cc(Br)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3809794 147269 0 None -43 3 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 503 12 3 6 3.5 COc1cc(Br)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
123204312 147250 0 None -74 3 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 425 11 3 5 2.7 Cc1cccc(C)c1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
CHEMBL3809532 147250 0 None -74 3 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 425 11 3 5 2.7 Cc1cccc(C)c1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
156767238 190116 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 435 10 1 5 4.3 COc1ccccc1N1CCN(CCCn2cc(CCCC(=O)O)c3ccccc32)CC1 10.1016/j.ejmech.2020.112616
CHEMBL4797460 190116 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 435 10 1 5 4.3 COc1ccccc1N1CCN(CCCn2cc(CCCC(=O)O)c3ccccc32)CC1 10.1016/j.ejmech.2020.112616
156767231 190081 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 453 10 1 4 5.3 O=C(O)CCCc1cn(CCCCN2CCN(c3ccccc3Cl)CC2)c2ccccc12 10.1016/j.ejmech.2020.112616
CHEMBL4797051 190081 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 453 10 1 4 5.3 O=C(O)CCCc1cn(CCCCN2CCN(c3ccccc3Cl)CC2)c2ccccc12 10.1016/j.ejmech.2020.112616
156767236 189736 0 None -9 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 449 11 1 5 4.7 COc1ccccc1N1CCN(CCCCn2cc(CCCC(=O)O)c3ccccc32)CC1 10.1016/j.ejmech.2020.112616
CHEMBL4792905 189736 0 None -9 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 449 11 1 5 4.7 COc1ccccc1N1CCN(CCCCn2cc(CCCC(=O)O)c3ccccc32)CC1 10.1016/j.ejmech.2020.112616
123437117 147147 0 None -23 3 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 461 12 3 6 2.8 COc1cc(Cl)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
CHEMBL3808417 147147 0 None -23 3 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 461 12 3 6 2.8 COc1cc(Cl)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
445154 10093 127 None 1 2 Rat 4.7 pIC50 = 4.7 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 228 2 3 3 3.0 Oc1ccc(cc1)/C=C/c1cc(O)cc(c1)O 10.1016/j.bmcl.2005.10.013
8741 10093 127 None 1 2 Rat 4.7 pIC50 = 4.7 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 228 2 3 3 3.0 Oc1ccc(cc1)/C=C/c1cc(O)cc(c1)O 10.1016/j.bmcl.2005.10.013
CHEMBL165 10093 127 None 1 2 Rat 4.7 pIC50 = 4.7 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 228 2 3 3 3.0 Oc1ccc(cc1)/C=C/c1cc(O)cc(c1)O 10.1016/j.bmcl.2005.10.013
DB02709 10093 127 None 1 2 Rat 4.7 pIC50 = 4.7 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 228 2 3 3 3.0 Oc1ccc(cc1)/C=C/c1cc(O)cc(c1)O 10.1016/j.bmcl.2005.10.013
10160408 147218 0 None -1 3 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 439 13 3 6 3.1 CCOc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3809248 147218 0 None -1 3 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 439 13 3 6 3.1 CCOc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
123415538 147155 0 None -8 3 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 491 11 3 5 3.6 CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccc(F)cc1Br 10.1021/acs.jmedchem.5b02023
CHEMBL3808511 147155 0 None -8 3 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 491 11 3 5 3.6 CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccc(F)cc1Br 10.1021/acs.jmedchem.5b02023
10606263 148329 0 None 81 3 Rat 7.6 pIC50 = 7.6 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1161 33 6 20 7.3 COc1cc2nc(N3CCN(C(=O)c4ccc(CNCCCCCCNCCSSCCNCCCCCCNCc5ccc(C(=O)N6CCN(c7nc(N)c8cc(OC)c(OC)cc8n7)CC6)cc5)cc4)CC3)nc(N)c2cc1OC 10.1021/jm000995w
CHEMBL384790 148329 0 None 81 3 Rat 7.6 pIC50 = 7.6 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1161 33 6 20 7.3 COc1cc2nc(N3CCN(C(=O)c4ccc(CNCCCCCCNCCSSCCNCCCCCCNCc5ccc(C(=O)N6CCN(c7nc(N)c8cc(OC)c(OC)cc8n7)CC6)cc5)cc4)CC3)nc(N)c2cc1OC 10.1021/jm000995w
76071739 149575 0 None -501 3 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 348 1 1 4 3.6 COc1ccc2[nH]c3c(c2c1)C[C@H]1c2cc4c(cc2CCN1C3)OCO4 10.1021/acs.jmedchem.6b01217
CHEMBL3892879 149575 0 None -501 3 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 348 1 1 4 3.6 COc1ccc2[nH]c3c(c2c1)C[C@H]1c2cc4c(cc2CCN1C3)OCO4 10.1021/acs.jmedchem.6b01217
10630100 103376 0 None 186 3 Rat 7.6 pIC50 = 7.6 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1161 33 6 20 7.3 COc1cc2nc(N3CCN(C(=O)c4ccccc4CNCCCCCCNCCSSCCNCCCCCCNCc4ccccc4C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)CC3)nc(N)c2cc1OC 10.1021/jm000995w
CHEMBL263289 103376 0 None 186 3 Rat 7.6 pIC50 = 7.6 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1161 33 6 20 7.3 COc1cc2nc(N3CCN(C(=O)c4ccccc4CNCCCCCCNCCSSCCNCCCCCCNCc4ccccc4C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)CC3)nc(N)c2cc1OC 10.1021/jm000995w
4151 10379 89 None -5 10 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.5b02023
493 10379 89 None -5 10 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.5b02023
5312125 10379 89 None -5 10 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.5b02023
CHEMBL24778 10379 89 None -5 10 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.5b02023
DB06207 10379 89 None -5 10 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.5b02023
123368349 147211 0 None -95 3 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 505 12 3 6 2.9 COc1cc(Br)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
CHEMBL3809175 147211 0 None -95 3 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 505 12 3 6 2.9 COc1cc(Br)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
145946986 174384 0 None 3 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 460 7 0 3 6.2 Clc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1 10.1016/j.bmcl.2018.03.070
CHEMBL4227241 174384 0 None 3 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 460 7 0 3 6.2 Clc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1 10.1016/j.bmcl.2018.03.070
CHEMBL4300995 174384 0 None 3 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 460 7 0 3 6.2 Clc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1 10.1016/j.bmcl.2018.03.070
10034371 172759 0 None 676 3 Rat 8.5 pIC50 = 8.5 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1277 47 6 20 10.9 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CNCCCCCCNCCSSCCNCCCCCCNCc4ccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)cc4)cc3)nc(N)c2cc1OC 10.1021/jm000995w
CHEMBL1203235 172759 0 None 676 3 Rat 8.5 pIC50 = 8.5 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1277 47 6 20 10.9 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CNCCCCCCNCCSSCCNCCCCCCNCc4ccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)cc4)cc3)nc(N)c2cc1OC 10.1021/jm000995w
CHEMBL425267 172759 0 None 676 3 Rat 8.5 pIC50 = 8.5 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1277 47 6 20 10.9 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CNCCCCCCNCCSSCCNCCCCCCNCc4ccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)cc4)cc3)nc(N)c2cc1OC 10.1021/jm000995w
123141715 147313 0 None -2 3 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 459 12 3 6 3.4 COc1cc(Cl)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3810401 147313 0 None -2 3 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 459 12 3 6 3.4 COc1cc(Cl)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 10.1021/acs.jmedchem.5b02023
156767234 189375 0 None -10 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 467 11 1 4 5.7 O=C(O)CCCc1cn(CCCCCN2CCN(c3ccccc3Cl)CC2)c2ccccc12 10.1016/j.ejmech.2020.112616
CHEMBL4788144 189375 0 None -10 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 467 11 1 4 5.7 O=C(O)CCCc1cn(CCCCCN2CCN(c3ccccc3Cl)CC2)c2ccccc12 10.1016/j.ejmech.2020.112616
123311113 147299 0 None -91 3 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 523 14 3 6 3.6 CCc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3810187 147299 0 None -91 3 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 523 14 3 6 3.6 CCc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c1 10.1021/acs.jmedchem.5b02023
127044893 147186 0 None -2 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 411 11 3 5 2.4 Cc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
CHEMBL3808878 147186 0 None -2 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 411 11 3 5 2.4 Cc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
127043026 147225 0 None -8 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 507 13 3 6 4.0 Cc1ccc(OCC(F)(F)F)c(OCCN[C@@H](C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3809314 147225 0 None -8 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 507 13 3 6 4.0 Cc1ccc(OCC(F)(F)F)c(OCCN[C@@H](C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1 10.1021/acs.jmedchem.5b02023
156767239 189179 0 None -38 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 463 12 1 5 5.1 COc1ccccc1N1CCN(CCCCCn2cc(CCCC(=O)O)c3ccccc32)CC1 10.1016/j.ejmech.2020.112616
CHEMBL4785526 189179 0 None -38 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
ChEMBL 463 12 1 5 5.1 COc1ccccc1N1CCN(CCCCCn2cc(CCCC(=O)O)c3ccccc32)CC1 10.1016/j.ejmech.2020.112616
123986550 147176 0 None -223 3 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 521 14 3 6 4.2 CCc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3808717 147176 0 None -223 3 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 521 14 3 6 4.2 CCc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1 10.1021/acs.jmedchem.5b02023
44406314 79613 0 None - 1 Rat 4.4 pIC50 = 4.4 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 270 1 3 5 2.6 O=c1oc2cc(O)ccc2cc1-c1cc(O)cc(O)c1 10.1016/j.bmcl.2005.10.013
CHEMBL200198 79613 0 None - 1 Rat 4.4 pIC50 = 4.4 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 270 1 3 5 2.6 O=c1oc2cc(O)ccc2cc1-c1cc(O)cc(O)c1 10.1016/j.bmcl.2005.10.013
44406313 79489 3 None - 1 Rat 4.4 pIC50 = 4.4 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 298 3 1 5 3.2 COc1cc(OC)cc(-c2cc3ccc(O)cc3oc2=O)c1 10.1016/j.bmcl.2005.10.013
CHEMBL199788 79489 3 None - 1 Rat 4.4 pIC50 = 4.4 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 298 3 1 5 3.2 COc1cc(OC)cc(-c2cc3ccc(O)cc3oc2=O)c1 10.1016/j.bmcl.2005.10.013
10034370 163771 0 None 10 3 Rat 8.3 pIC50 = 8.3 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1277 47 6 20 10.9 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CNCCCCCCNCCSSCCNCCCCCCNCc4cccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)c4)c3)nc(N)c2cc1OC 10.1021/jm000995w
CHEMBL1203232 163771 0 None 10 3 Rat 8.3 pIC50 = 8.3 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1277 47 6 20 10.9 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CNCCCCCCNCCSSCCNCCCCCCNCc4cccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)c4)c3)nc(N)c2cc1OC 10.1021/jm000995w
CHEMBL407315 163771 0 None 10 3 Rat 8.3 pIC50 = 8.3 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1277 47 6 20 10.9 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CNCCCCCCNCCSSCCNCCCCCCNCc4cccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)c4)c3)nc(N)c2cc1OC 10.1021/jm000995w
134142282 152468 0 None -229 3 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 348 1 1 4 3.6 COc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4 10.1021/acs.jmedchem.6b01217
CHEMBL3916182 152468 0 None -229 3 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 348 1 1 4 3.6 COc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4 10.1021/acs.jmedchem.6b01217
123644751 147281 0 None -125 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 529 13 3 6 3.7 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
CHEMBL3810005 147281 0 None -125 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 529 13 3 6 3.7 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
44406275 79530 0 None - 1 Rat 4.4 pIC50 = 4.4 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 312 4 0 5 3.5 COc1cc(OC)cc(-c2cc3cc(OC)ccc3oc2=O)c1 10.1016/j.bmcl.2005.10.013
CHEMBL199904 79530 0 None - 1 Rat 4.4 pIC50 = 4.4 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 312 4 0 5 3.5 COc1cc(OC)cc(-c2cc3cc(OC)ccc3oc2=O)c1 10.1016/j.bmcl.2005.10.013
123378354 147165 0 None -6 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 493 11 3 5 3.0 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc(F)cc1Br 10.1021/acs.jmedchem.5b02023
CHEMBL3808595 147165 0 None -6 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 493 11 3 5 3.0 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc(F)cc1Br 10.1021/acs.jmedchem.5b02023
145947047 174414 0 None 1 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 425 7 0 2 6.6 c1ccc(C2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1 10.1016/j.bmcl.2018.03.070
CHEMBL4227513 174414 0 None 1 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 425 7 0 2 6.6 c1ccc(C2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1 10.1016/j.bmcl.2018.03.070
CHEMBL4301557 174414 0 None 1 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 425 7 0 2 6.6 c1ccc(C2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1 10.1016/j.bmcl.2018.03.070
127044906 147196 0 None -7 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 529 13 3 6 3.7 C[C@@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
CHEMBL3808981 147196 0 None -7 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 529 13 3 6 3.7 C[C@@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
123322716 147301 0 None -17 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 425 12 3 5 2.7 CCc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
CHEMBL3810198 147301 0 None -17 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 425 12 3 5 2.7 CCc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
86344174 147246 0 None -251 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 507 13 3 6 4.0 Cc1ccc(OCC(F)(F)F)c(OCCN[C@H](C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3809490 147246 0 None -251 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 507 13 3 6 4.0 Cc1ccc(OCC(F)(F)F)c(OCCN[C@H](C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1 10.1021/acs.jmedchem.5b02023
123183757 147255 0 None -10 3 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 445 12 3 6 2.3 COc1cc(F)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
CHEMBL3809600 147255 0 None -10 3 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 445 12 3 6 2.3 COc1cc(F)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
44347716 23080 0 None 3 3 Rat 5.3 pIC50 = 5.3 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 590 27 4 8 6.3 COc1cccc(CNCCCCCCNCCSSCCNCCCCCCNCc2ccccc2OC)c1 10.1021/jm000995w
CHEMBL122621 23080 0 None 3 3 Rat 5.3 pIC50 = 5.3 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 590 27 4 8 6.3 COc1cccc(CNCCCCCCNCCSSCCNCCCCCCNCc2ccccc2OC)c1 10.1021/jm000995w
123801568 147267 0 None -190 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 441 11 3 7 1.9 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc2c(c1)OCO2 10.1021/acs.jmedchem.5b02023
CHEMBL3809781 147267 0 None -190 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 441 11 3 7 1.9 CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc2c(c1)OCO2 10.1021/acs.jmedchem.5b02023
44406315 79425 0 None - 1 Rat 4.3 pIC50 = 4.3 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 312 4 0 5 3.5 COc1cc(OC)cc(-c2cc3ccc(OC)cc3oc2=O)c1 10.1016/j.bmcl.2005.10.013
CHEMBL199527 79425 0 None - 1 Rat 4.3 pIC50 = 4.3 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 312 4 0 5 3.5 COc1cc(OC)cc(-c2cc3ccc(OC)cc3oc2=O)c1 10.1016/j.bmcl.2005.10.013
4418 40996 85 None 1 18 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmcl.2018.03.070
CHEMBL142635 40996 85 None 1 18 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmcl.2018.03.070
4151 10379 89 None -5 10 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.6b01217
493 10379 89 None -5 10 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.6b01217
5312125 10379 89 None -5 10 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.6b01217
CHEMBL24778 10379 89 None -5 10 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.6b01217
DB06207 10379 89 None -5 10 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/acs.jmedchem.6b01217
123183788 147304 0 None -7 3 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 441 12 3 6 2.4 COc1cc(C)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
CHEMBL3810220 147304 0 None -7 3 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 441 12 3 6 2.4 COc1cc(C)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 10.1021/acs.jmedchem.5b02023
131978695 157640 0 None -5 3 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 440 5 1 4 5.4 COc1ccc2[nH]c3c(c2c1)CC1c2cc(OCc4ccccc4)c(OC)cc2CCN1C3 10.1021/acs.jmedchem.6b01217
CHEMBL3957222 157640 0 None -5 3 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 440 5 1 4 5.4 COc1ccc2[nH]c3c(c2c1)CC1c2cc(OCc4ccccc4)c(OC)cc2CCN1C3 10.1021/acs.jmedchem.6b01217
145946630 174352 0 None -12 3 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 456 8 0 4 5.5 COc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1 10.1016/j.bmcl.2018.03.070
CHEMBL4224794 174352 0 None -12 3 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 456 8 0 4 5.5 COc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1 10.1016/j.bmcl.2018.03.070
CHEMBL4300618 174352 0 None -12 3 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 456 8 0 4 5.5 COc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1 10.1016/j.bmcl.2018.03.070
10820251 103397 0 None 208 3 Rat 8.1 pIC50 = 8.1 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1277 47 6 20 10.9 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCNCCSSCCNCCCCCCNCc3ccccc3C(=O)N(C)CCCCCCN(C)c3nc(N)c4cc(OC)c(OC)cc4n3)nc(N)c2cc1OC 10.1021/jm000995w
CHEMBL1203233 103397 0 None 208 3 Rat 8.1 pIC50 = 8.1 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1277 47 6 20 10.9 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCNCCSSCCNCCCCCCNCc3ccccc3C(=O)N(C)CCCCCCN(C)c3nc(N)c4cc(OC)c(OC)cc4n3)nc(N)c2cc1OC 10.1021/jm000995w
CHEMBL263434 103397 0 None 208 3 Rat 8.1 pIC50 = 8.1 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1277 47 6 20 10.9 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCNCCSSCCNCCCCCCNCc3ccccc3C(=O)N(C)CCCCCCN(C)c3nc(N)c4cc(OC)c(OC)cc4n3)nc(N)c2cc1OC 10.1021/jm000995w
10582125 88609 0 None 47 3 Rat 7.1 pIC50 = 7.1 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1161 33 6 20 7.3 COc1cc2nc(N3CCN(C(=O)c4cccc(CNCCCCCCNCCSSCCNCCCCCCNCc5cccc(C(=O)N6CCN(c7nc(N)c8cc(OC)c(OC)cc8n7)CC6)c5)c4)CC3)nc(N)c2cc1OC 10.1021/jm000995w
CHEMBL216443 88609 0 None 47 3 Rat 7.1 pIC50 = 7.1 Functional
Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from ratAntagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoceptors on isolated thoracic aorta from rat
ChEMBL 1161 33 6 20 7.3 COc1cc2nc(N3CCN(C(=O)c4cccc(CNCCCCCCNCCSSCCNCCCCCCNCc5cccc(C(=O)N6CCN(c7nc(N)c8cc(OC)c(OC)cc8n7)CC6)c5)c4)CC3)nc(N)c2cc1OC 10.1021/jm000995w
145947950 174512 0 None -1 3 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 440 7 0 3 5.8 Cc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1 10.1016/j.bmcl.2018.03.070
CHEMBL4224703 174512 0 None -1 3 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 440 7 0 3 5.8 Cc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1 10.1016/j.bmcl.2018.03.070
CHEMBL4302771 174512 0 None -1 3 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
ChEMBL 440 7 0 3 5.8 Cc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1 10.1016/j.bmcl.2018.03.070
134149598 155256 0 None -33 2 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 336 0 1 3 3.7 Fc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4 10.1021/acs.jmedchem.6b01217
CHEMBL3938121 155256 0 None -33 2 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1D adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
ChEMBL 336 0 1 3 3.7 Fc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4 10.1021/acs.jmedchem.6b01217
123576734 147202 0 None -15 3 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 455 13 3 6 2.7 CCc1ccc(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c(OC)c1 10.1021/acs.jmedchem.5b02023
CHEMBL3809032 147202 0 None -15 3 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 455 13 3 6 2.7 CCc1ccc(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c(OC)c1 10.1021/acs.jmedchem.5b02023
123854385 147294 0 None -72 3 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 527 13 3 6 4.3 CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1cc(Cl)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
CHEMBL3810145 147294 0 None -72 3 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 527 13 3 6 4.3 CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1cc(Cl)ccc1OCC(F)(F)F 10.1021/acs.jmedchem.5b02023
44406281 79480 3 None - 1 Rat 4.0 pIC50 = 4.0 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 286 1 4 6 2.3 O=c1oc2c(O)cc(O)cc2cc1-c1cc(O)cc(O)c1 10.1016/j.bmcl.2005.10.013
CHEMBL199739 79480 3 None - 1 Rat 4.0 pIC50 = 4.0 Functional
Noradrenaline induced vasorelaxant activity in intact rat aortic ringsNoradrenaline induced vasorelaxant activity in intact rat aortic rings
ChEMBL 286 1 4 6 2.3 O=c1oc2c(O)cc(O)cc2cc1-c1cc(O)cc(O)c1 10.1016/j.bmcl.2005.10.013
123393714 147252 0 None -3 3 Human 6.0 pIC50 = 6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 439 11 3 5 3.1 Cc1ccc(C)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c1C 10.1021/acs.jmedchem.5b02023
CHEMBL3809543 147252 0 None -3 3 Human 6.0 pIC50 = 6 Functional
Antagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at alpha-1D adrenergic receptor (unknown origin) transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
ChEMBL 439 11 3 5 3.1 Cc1ccc(C)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c1C 10.1021/acs.jmedchem.5b02023
16121006 18613 0 None - 0 Rat 10.7 pKd = 10.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182182 18613 0 None - 0 Rat 10.7 pKd = 10.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL217469 18613 0 None - 0 Rat 10.7 pKd = 10.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
11638677 91364 0 None - 2 Rat 10.6 pKd = 10.6 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 340 5 0 5 2.8 COc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2011.04.032
CHEMBL2153423 91364 0 None - 2 Rat 10.6 pKd = 10.6 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 340 5 0 5 2.8 COc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2011.04.032
CHEMBL2220978 91364 0 None - 2 Rat 10.6 pKd = 10.6 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 340 5 0 5 2.8 COc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2011.04.032
129211 10521 78 None - 14 Rat 10.6 pKd = 10.6 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
2562 10521 78 None - 14 Rat 10.6 pKd = 10.6 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
488 10521 78 None - 14 Rat 10.6 pKd = 10.6 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
CHEMBL836 10521 78 None - 14 Rat 10.6 pKd = 10.6 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
DB00706 10521 78 None - 14 Rat 10.6 pKd = 10.6 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
9824384 125565 1 None - 0 Rat 10.1 pKd = 10.1 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL342062 125565 1 None - 0 Rat 10.1 pKd = 10.1 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
4209 9937 75 None - 17 Rat 9.8 pKd = 9.8 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2011.04.032
4893 9937 75 None - 17 Rat 9.8 pKd = 9.8 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2011.04.032
503 9937 75 None - 17 Rat 9.8 pKd = 9.8 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2011.04.032
5385 9937 75 None - 17 Rat 9.8 pKd = 9.8 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2011.04.032
CHEMBL2 9937 75 None - 17 Rat 9.8 pKd = 9.8 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2011.04.032
DB00457 9937 75 None - 17 Rat 9.8 pKd = 9.8 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2011.04.032
11742834 172549 0 None - 0 Rat 9.6 pKd = 9.6 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 419 9 1 5 4.7 COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1 10.1021/jm011066n
CHEMBL42472 172549 0 None - 0 Rat 9.6 pKd = 9.6 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 419 9 1 5 4.7 COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1 10.1021/jm011066n
10814913 42692 0 None - 0 Rat 9.4 pKd = 9.4 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 489 12 1 8 4.3 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CCl)o3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL144238 42692 0 None - 0 Rat 9.4 pKd = 9.4 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 489 12 1 8 4.3 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CCl)o3)nc(N)c2cc1OC 10.1021/jm9810654
50905381 63124 0 None - 0 Rat 9.3 pKd = 9.3 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
ChEMBL 422 11 2 6 2.7 COc1ccc(C[C@@H](C)NCCOc2ccccc2OC(C)C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
CHEMBL1630938 63124 0 None - 0 Rat 9.3 pKd = 9.3 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
ChEMBL 422 11 2 6 2.7 COc1ccc(C[C@@H](C)NCCOc2ccccc2OC(C)C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
9891213 168281 0 None - 0 Rat 9.3 pKd = 9.3 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 477 5 1 8 4.0 COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4128084 168281 0 None - 0 Rat 9.3 pKd = 9.3 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 477 5 1 8 4.0 COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
132266 8061 12 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm8016046
486 8061 12 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm8016046
CHEMBL423294 8061 12 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm8016046
13305910 18608 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182155 18608 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL215421 18608 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL3741808 18608 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
13305910 18608 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL1182155 18608 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL215421 18608 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL3741808 18608 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
14423371 104230 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 441 11 1 8 3.6 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL27013 104230 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 441 11 1 8 3.6 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1021/jm9810654
14423371 104230 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 441 11 1 8 3.6 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1016/s0960-894x(98)00217-0
CHEMBL27013 104230 1 None - 0 Rat 9.2 pKd = 9.2 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 441 11 1 8 3.6 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1016/s0960-894x(98)00217-0
10527469 163044 3 None - 0 Rat 9.1 pKd = 9.1 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm970364a
CHEMBL40650 163044 3 None - 0 Rat 9.1 pKd = 9.1 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm970364a
11430126 67337 0 None - 0 Rat 9.1 pKd = 9.1 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 421 4 1 9 2.0 COc1cc2nc(N3CCN(C(=O)C4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
CHEMBL175934 67337 0 None - 0 Rat 9.1 pKd = 9.1 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 421 4 1 9 2.0 COc1cc2nc(N3CCN(C(=O)C4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
11751173 70200 0 None - 0 Rat 9.1 pKd = 9.1 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 445 4 1 9 2.3 COc1cc2nc(N3CCN(C4=CC(=O)c5ccccc5C4=O)CC3)nc(N)c2cc1OC 10.1021/jm049153d
CHEMBL179743 70200 0 None - 0 Rat 9.1 pKd = 9.1 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 445 4 1 9 2.3 COc1cc2nc(N3CCN(C4=CC(=O)c5ccccc5C4=O)CC3)nc(N)c2cc1OC 10.1021/jm049153d
11430491 69775 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 435 5 1 9 2.4 COc1cc2nc(N3CCN(C(=O)CC4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
CHEMBL178673 69775 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 435 5 1 9 2.4 COc1cc2nc(N3CCN(C(=O)CC4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
24897950 63126 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
ChEMBL 462 11 2 6 2.9 COc1ccc(C[C@@H](C)NCCOc2ccccc2OCC(F)(F)F)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
CHEMBL1630940 63126 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
ChEMBL 462 11 2 6 2.9 COc1ccc(C[C@@H](C)NCCOc2ccccc2OCC(F)(F)F)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
4209 9937 75 None - 17 Rat 9.0 pKd = 9.0 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
4893 9937 75 None - 17 Rat 9.0 pKd = 9.0 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
503 9937 75 None - 17 Rat 9.0 pKd = 9.0 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
5385 9937 75 None - 17 Rat 9.0 pKd = 9.0 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
CHEMBL2 9937 75 None - 17 Rat 9.0 pKd = 9.0 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
DB00457 9937 75 None - 17 Rat 9.0 pKd = 9.0 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
11994665 18606 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 391 8 1 5 4.2 COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182151 18606 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 391 8 1 5 4.2 COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL215151 18606 0 None - 0 Rat 9.0 pKd = 9.0 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 391 8 1 5 4.2 COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
3157 8252 71 None - 22 Rat 9.0 pKd = 9.0 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
7170 8252 71 None - 22 Rat 9.0 pKd = 9.0 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
954 8252 71 None - 22 Rat 9.0 pKd = 9.0 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
CHEMBL707 8252 71 None - 22 Rat 9.0 pKd = 9.0 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
DB00590 8252 71 None - 22 Rat 9.0 pKd = 9.0 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
4209 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
4893 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
503 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
5385 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
CHEMBL2 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
DB00457 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
4209 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(98)00217-0
4893 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(98)00217-0
503 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(98)00217-0
5385 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(98)00217-0
CHEMBL2 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(98)00217-0
DB00457 9937 75 None - 17 Rat 8.9 pKd = 8.9 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(98)00217-0
3584 10549 64 None - 11 Rat 8.8 pKd = 8.8 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
5401 10549 64 None - 11 Rat 8.8 pKd = 8.8 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
7302 10549 64 None - 11 Rat 8.8 pKd = 8.8 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
CHEMBL611 10549 64 None - 11 Rat 8.8 pKd = 8.8 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
DB01162 10549 64 None - 11 Rat 8.8 pKd = 8.8 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
499 10849 18 None - 1 Rat 8.8 pKd = 8.8 Functional
Antagonistic activity at ADRA1D in rat thoracic aortaAntagonistic activity at ADRA1D in rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1016/j.bmcl.2005.09.027
5685 10849 18 None - 1 Rat 8.8 pKd = 8.8 Functional
Antagonistic activity at ADRA1D in rat thoracic aortaAntagonistic activity at ADRA1D in rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1016/j.bmcl.2005.09.027
CHEMBL25554 10849 18 None - 1 Rat 8.8 pKd = 8.8 Functional
Antagonistic activity at ADRA1D in rat thoracic aortaAntagonistic activity at ADRA1D in rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1016/j.bmcl.2005.09.027
499 10849 18 None - 1 Rat 8.8 pKd = 8.8 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm011066n
5685 10849 18 None - 1 Rat 8.8 pKd = 8.8 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm011066n
CHEMBL25554 10849 18 None - 1 Rat 8.8 pKd = 8.8 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm011066n
10763212 174975 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 394 9 1 6 3.3 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)C2CC2)CC1 10.1021/jm970166j
CHEMBL433348 174975 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 394 9 1 6 3.3 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)C2CC2)CC1 10.1021/jm970166j
44289437 176642 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 431 9 1 5 4.7 COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O 10.1021/jm011066n
CHEMBL44403 176642 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 431 9 1 5 4.7 COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O 10.1021/jm011066n
4209 9937 75 None - 17 Rat 8.7 pKd = 8.7 Functional
In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00370a011
4893 9937 75 None - 17 Rat 8.7 pKd = 8.7 Functional
In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00370a011
503 9937 75 None - 17 Rat 8.7 pKd = 8.7 Functional
In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00370a011
5385 9937 75 None - 17 Rat 8.7 pKd = 8.7 Functional
In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00370a011
CHEMBL2 9937 75 None - 17 Rat 8.7 pKd = 8.7 Functional
In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00370a011
DB00457 9937 75 None - 17 Rat 8.7 pKd = 8.7 Functional
In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.In vitro antagonist activity against (-)-phenylephrine or (-)-norepinephrine-induced alpha1-adrenoceptor-mediated vasoconstriction of rabbit isolated pulmonary artery.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00370a011
44417713 19194 0 None - 0 Rat 8.0 pKd = 8 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1185884 19194 0 None - 0 Rat 8.0 pKd = 8 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL439346 19194 0 None - 0 Rat 8.0 pKd = 8 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
10501886 118178 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 413 8 2 7 2.1 COc1ccccc1N1CCN(CCCNc2ncc(O)cc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL327232 118178 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 413 8 2 7 2.1 COc1ccccc1N1CCN(CCCNc2ncc(O)cc2C(=O)N(C)C)CC1 10.1021/jm970166j
10833725 213290 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 381 7 1 5 2.7 Cc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL88435 213290 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 381 7 1 5 2.7 Cc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10499343 213304 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 369 8 2 6 1.8 COc1ccccc1N1CCN(CCCNc2ncccc2C(N)=O)CC1 10.1021/jm970166j
CHEMBL88512 213304 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 369 8 2 6 1.8 COc1ccccc1N1CCN(CCCNc2ncccc2C(N)=O)CC1 10.1021/jm970166j
10500734 213358 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 392 7 1 6 2.3 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C#N)CC1 10.1021/jm970166j
CHEMBL88856 213358 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 392 7 1 6 2.3 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C#N)CC1 10.1021/jm970166j
10646065 213681 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 425 8 2 6 3.2 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)NC(C)(C)C)CC1 10.1021/jm970166j
CHEMBL90874 213681 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 425 8 2 6 3.2 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)NC(C)(C)C)CC1 10.1021/jm970166j
10526964 213744 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 437 10 1 6 3.2 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC2CC2)CC1 10.1021/jm970166j
CHEMBL91278 213744 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 437 10 1 6 3.2 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC2CC2)CC1 10.1021/jm970166j
10598692 213923 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 429 9 1 5 4.6 COc1ccccc1N1CCN(CCCNc2ccccc2C(=O)c2ccccc2)CC1 10.1021/jm970166j
CHEMBL92259 213923 0 None - 0 Rat 8.0 pKd = 8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 429 9 1 5 4.6 COc1ccccc1N1CCN(CCCNc2ccccc2C(=O)c2ccccc2)CC1 10.1021/jm970166j
10671310 213704 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 451 8 1 6 3.3 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OC(F)(F)F)CC1 10.1021/jm970166j
CHEMBL91036 213704 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 451 8 1 6 3.3 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OC(F)(F)F)CC1 10.1021/jm970166j
10647512 213804 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 456 8 2 6 1.6 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)c[nH]c3ccn[n+]2-3)CC1 10.1021/jm970166j
CHEMBL91547 213804 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 456 8 2 6 1.6 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)c[nH]c3ccn[n+]2-3)CC1 10.1021/jm970166j
10815708 213877 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 515 9 1 6 4.5 CN(C)C(=O)c1cnc2ccccc2c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
CHEMBL91989 213877 0 None - 0 Rat 7.0 pKd = 7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 515 9 1 6 4.5 CN(C)C(=O)c1cnc2ccccc2c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
10788615 213795 0 None - 0 Rat 6.0 pKd = 6 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 427 9 1 7 2.4 COc1ccc(N2CCN(CCCNc3ncccc3C(=O)N(C)C)CC2)c(OC)c1 10.1021/jm970166j
CHEMBL91480 213795 0 None - 0 Rat 6.0 pKd = 6 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 427 9 1 7 2.4 COc1ccc(N2CCN(CCCNc3ncccc3C(=O)N(C)C)CC2)c(OC)c1 10.1021/jm970166j
11994915 18604 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 391 8 1 5 4.2 COc1cc(-c2ccccc2)ccc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182145 18604 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 391 8 1 5 4.2 COc1cc(-c2ccccc2)ccc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL214762 18604 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 391 8 1 5 4.2 COc1cc(-c2ccccc2)ccc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
10549596 91380 1 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153553 91380 1 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2221147 91380 1 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1 10.1016/j.ejmech.2012.09.049
4418 40996 85 None - 18 Rat 7.9 pKd = 7.9 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmcl.2018.01.068
CHEMBL142635 40996 85 None - 18 Rat 7.9 pKd = 7.9 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmcl.2018.01.068
52942664 24416 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 500 8 2 6 2.7 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
CHEMBL1258345 24416 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 500 8 2 6 2.7 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
11135150 14375 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 435 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm021078o
CHEMBL1087942 14375 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 435 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm021078o
CHEMBL287686 14375 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 435 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm021078o
11454386 69881 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 477 8 1 9 3.6 COc1cc2nc(N3CCN(C(=O)CCCCC4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
CHEMBL178923 69881 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat thoracic aorta (Alpha-1D adrenoceptor)
ChEMBL 477 8 1 9 3.6 COc1cc2nc(N3CCN(C(=O)CCCCC4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
10813278 113717 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 446 8 1 6 3.5 Cc1ccc(N2CCN(CCCNc3ncccc3C(=O)N(C)C)CC2)c(-n2cccc2)c1 10.1021/jm970166j
CHEMBL314880 113717 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 446 8 1 6 3.5 Cc1ccc(N2CCN(CCCNc3ncccc3C(=O)N(C)C)CC2)c(-n2cccc2)c1 10.1021/jm970166j
10693071 213253 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 413 8 0 5 3.7 COc1ccccc1N1CCN(CCCSc2ccccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL88181 213253 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 413 8 0 5 3.7 COc1ccccc1N1CCN(CCCSc2ccccc2C(=O)N(C)C)CC1 10.1021/jm970166j
9893282 213248 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 533 9 1 8 3.5 Cc1nn(C)c2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccccc4OCC(F)(F)F)CC3)c12 10.1021/jm970166j
CHEMBL88160 213248 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 533 9 1 8 3.5 Cc1nn(C)c2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccccc4OCC(F)(F)F)CC3)c12 10.1021/jm970166j
10530686 213682 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 549 9 1 6 5.2 CN(C)C(=O)c1cnc2c(Cl)cccc2c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
CHEMBL90878 213682 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 549 9 1 6 5.2 CN(C)C(=O)c1cnc2c(Cl)cccc2c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
44284394 17961 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 373 9 1 6 3.0 COc1cccc(OC)c1OCCNCC1CO[C@](C)(c2ccccc2)O1 10.1021/jm021078o
CHEMBL1178677 17961 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 373 9 1 6 3.0 COc1cccc(OC)c1OCCNCC1CO[C@](C)(c2ccccc2)O1 10.1021/jm021078o
CHEMBL36978 17961 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 373 9 1 6 3.0 COc1cccc(OC)c1OCCNCC1CO[C@](C)(c2ccccc2)O1 10.1021/jm021078o
10767948 42723 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 508 13 1 8 4.1 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CN(C)C)cc3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL144263 42723 0 None - 0 Rat 7.9 pKd = 7.9 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 508 13 1 8 4.1 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CN(C)C)cc3)nc(N)c2cc1OC 10.1021/jm9810654
145962945 168122 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 511 5 1 7 4.6 COc1cc2nc(N3CCN(C(=O)Cc4ccc5ccccc5c4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4125846 168122 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 511 5 1 7 4.6 COc1cc2nc(N3CCN(C(=O)Cc4ccc5ccccc5c4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
11273296 177075 0 None - 0 Rat 5.9 pKd = 5.9 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 586 11 1 8 2.9 CCOC(=O)CN1C(=O)N(CC(O)CN2CCN(c3ccccc3OC)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
CHEMBL444648 177075 0 None - 0 Rat 5.9 pKd = 5.9 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 586 11 1 8 2.9 CCOC(=O)CN1C(=O)N(CC(O)CN2CCN(c3ccccc3OC)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
49800167 24453 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 514 9 2 6 3.1 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
CHEMBL1258457 24453 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 514 9 2 6 3.1 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
10531768 42426 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 607 20 2 9 5.2 CNCCCCCCN(C)Cc1cccc(C(=O)N(C)CCCCCCN(C)c2nc(N)c3cc(OC)c(OC)cc3n2)c1 10.1021/jm9810654
CHEMBL144000 42426 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 607 20 2 9 5.2 CNCCCCCCN(C)Cc1cccc(C(=O)N(C)CCCCCCN(C)c2nc(N)c3cc(OC)c(OC)cc3n2)c1 10.1021/jm9810654
44586429 191076 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 514 8 1 6 3.0 COc1ccccc1N1CCN(CC(O)CN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
CHEMBL484102 191076 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 514 8 1 6 3.0 COc1ccccc1N1CCN(CC(O)CN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
145960918 168307 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 427 3 1 7 3.2 COc1cc2nc(N3CCN(C(=O)C(C)(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4128460 168307 0 None - 0 Rat 6.9 pKd = 6.9 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 427 3 1 7 3.2 COc1cc2nc(N3CCN(C(=O)C(C)(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
52945071 24415 0 None - 0 Rat 5.8 pKd = 5.8 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 470 7 2 5 2.7 O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1CC(O)CN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
CHEMBL1258344 24415 0 None - 0 Rat 5.8 pKd = 5.8 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 470 7 2 5 2.7 O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1CC(O)CN1CCN(c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
145971816 171311 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 412 8 1 6 2.6 COC(=O)Cc1ccc(OC[C@@H](O)CN2CCN(c3cc(C)ccc3C)CC2)cc1 10.1016/j.bmcl.2018.01.068
CHEMBL4214992 171311 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 412 8 1 6 2.6 COC(=O)Cc1ccc(OC[C@@H](O)CN2CCN(c3cc(C)ccc3C)CC2)cc1 10.1016/j.bmcl.2018.01.068
10693026 112730 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 412 9 1 6 2.8 CCOc1ccccc1OCCNC1CCN(c2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL312935 112730 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 412 9 1 6 2.8 CCOc1ccccc1OCCNC1CCN(c2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10572854 119343 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 396 8 1 5 3.0 COc1ccccc1N1CCN(CCCNc2ccccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL330060 119343 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 396 8 1 5 3.0 COc1ccccc1N1CCN(CCCNc2ccccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10552132 119565 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 465 9 1 6 3.3 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
CHEMBL330579 119565 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 465 9 1 6 3.3 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
10642742 213574 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 367 7 1 5 2.4 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2)CC1 10.1021/jm970166j
CHEMBL90287 213574 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 367 7 1 5 2.4 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2)CC1 10.1021/jm970166j
145953314 168208 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 441 7 1 7 3.8 CCCCCC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)cc3n2)[C@@H]2CCCC[C@@H]21 10.1016/j.bmc.2018.05.023
CHEMBL4127078 168208 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 441 7 1 7 3.8 CCCCCC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)cc3n2)[C@@H]2CCCC[C@@H]21 10.1016/j.bmc.2018.05.023
10744240 113811 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 508 9 2 7 2.8 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C(N)=O)cccc23)CC1 10.1021/jm970166j
CHEMBL315496 113811 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 508 9 2 7 2.8 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C(N)=O)cccc23)CC1 10.1021/jm970166j
10577066 119189 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 490 8 2 6 2.3 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)c[nH]c3c(Cl)cn[n+]2-3)CC1 10.1021/jm970166j
CHEMBL329773 119189 0 None - 0 Rat 6.8 pKd = 6.8 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 490 8 2 6 2.3 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)c[nH]c3c(Cl)cn[n+]2-3)CC1 10.1021/jm970166j
11133288 172812 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 407 12 1 5 4.3 COc1cccc(OC)c1OCCNCCOc1ccccc1Cc1ccccc1 10.1021/jm011066n
CHEMBL42558 172812 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 407 12 1 5 4.3 COc1cccc(OC)c1OCCNCCOc1ccccc1Cc1ccccc1 10.1021/jm011066n
145962817 168298 0 None - 0 Rat 5.8 pKd = 5.8 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 385 3 1 7 2.2 COc1cc2nc(N3CCN(C(C)=O)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4128311 168298 0 None - 0 Rat 5.8 pKd = 5.8 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 385 3 1 7 2.2 COc1cc2nc(N3CCN(C(C)=O)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
44289248 175755 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 435 9 1 5 5.4 COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2S1 10.1021/jm011066n
CHEMBL43905 175755 0 None - 0 Rat 7.8 pKd = 7.8 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 435 9 1 5 5.4 COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2S1 10.1021/jm011066n
44417706 18607 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 395 8 1 6 3.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1 10.1021/jm060358r
CHEMBL1182152 18607 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 395 8 1 6 3.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1 10.1021/jm060358r
CHEMBL215188 18607 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 395 8 1 6 3.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1 10.1021/jm060358r
10743978 128081 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 499 12 1 7 4.7 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CCl)cc3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL358060 128081 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 499 12 1 7 4.7 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CCl)cc3)nc(N)c2cc1OC 10.1021/jm9810654
145978803 170617 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 398 8 1 6 2.3 COC(=O)Cc1ccc(OCC(O)CN2CCN(c3ccccc3C)CC2)cc1 10.1016/j.bmcl.2018.01.068
CHEMBL4206435 170617 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 398 8 1 6 2.3 COC(=O)Cc1ccc(OCC(O)CN2CCN(c3ccccc3C)CC2)cc1 10.1016/j.bmcl.2018.01.068
10574245 118299 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 422 8 1 7 2.3 COc1ccccc1N1CCN(CCCNc2ncc(C#N)cc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL327872 118299 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 422 8 1 7 2.3 COc1ccccc1N1CCN(CCCNc2ncc(C#N)cc2C(=O)N(C)C)CC1 10.1021/jm970166j
9865577 119086 2 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 1 6 2.4 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL329160 119086 2 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 1 6 2.4 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
44323795 213387 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 410 8 1 5 3.3 COc1ccccc1N1CCN(CCCNc2cc(C)ccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL89030 213387 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 410 8 1 5 3.3 COc1ccccc1N1CCN(CCCNc2cc(C)ccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10550225 213861 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 423 8 1 6 3.0 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N2CCCC2)CC1 10.1021/jm970166j
CHEMBL91876 213861 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 423 8 1 6 3.0 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N2CCCC2)CC1 10.1021/jm970166j
44586430 193809 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 528 9 1 6 3.4 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
CHEMBL490865 193809 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 528 9 1 6 3.4 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)N(C)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
10506159 118177 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 520 8 1 9 3.4 Cc1nn(C)c2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccc(F)cc4-c4ncco4)CC3)c12 10.1021/jm970166j
CHEMBL327231 118177 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 520 8 1 9 3.4 Cc1nn(C)c2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccc(F)cc4-c4ncco4)CC3)c12 10.1021/jm970166j
10719536 127921 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 480 12 2 8 3.5 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN)c3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL357669 127921 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 480 12 2 8 3.5 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN)c3)nc(N)c2cc1OC 10.1021/jm9810654
10430193 168377 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 385 3 1 7 2.2 COc1cc2nc(N3CCN(C(C)=O)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4129461 168377 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 385 3 1 7 2.2 COc1cc2nc(N3CCN(C(C)=O)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
3584 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
5401 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
7302 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
CHEMBL611 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
DB01162 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced contractile response
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.bmcl.2018.01.068
10363912 13310 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm021078o
CHEMBL1082862 13310 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm021078o
CHEMBL286003 13310 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm021078o
3584 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
5401 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
7302 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
CHEMBL611 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
DB01162 10549 64 None - 11 Rat 8.7 pKd = 8.7 Functional
In vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aortaIn vitro antagonism against Alpha-1D adrenergic receptor using phenylephrine (PE) challenge in rat aorta
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
499 10849 18 None - 1 Rat 8.6 pKd = 8.6 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm060358r
5685 10849 18 None - 1 Rat 8.6 pKd = 8.6 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm060358r
CHEMBL25554 10849 18 None - 1 Rat 8.6 pKd = 8.6 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm060358r
499 10849 18 None - 1 Rat 8.6 pKd = 8.6 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm021078o
5685 10849 18 None - 1 Rat 8.6 pKd = 8.6 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm021078o
CHEMBL25554 10849 18 None - 1 Rat 8.6 pKd = 8.6 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm021078o
10767688 43159 0 None - 0 Rat 8.6 pKd = 8.6 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 499 12 1 7 4.7 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CCl)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL144677 43159 0 None - 0 Rat 8.6 pKd = 8.6 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 499 12 1 7 4.7 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CCl)nc(N)c2cc1OC 10.1021/jm9810654
10344976 107992 2 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 477 11 1 10 3.4 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL29591 107992 2 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 477 11 1 10 3.4 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1021/jm9810654
10344976 107992 2 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 477 11 1 10 3.4 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1016/s0960-894x(98)00217-0
CHEMBL29591 107992 2 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 477 11 1 10 3.4 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1016/s0960-894x(98)00217-0
50905589 63128 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
ChEMBL 406 7 2 6 2.1 COc1ccc(C[C@@H](C)NC[C@@H]2Oc3ccccc3O[C@@H]2C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
CHEMBL1630942 63128 0 None - 0 Rat 7.7 pKd = 7.7 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
ChEMBL 406 7 2 6 2.1 COc1ccc(C[C@@H](C)NC[C@@H]2Oc3ccccc3O[C@@H]2C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
44428847 99068 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL242723 99068 0 None - 0 Rat 6.7 pKd = 6.7 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
6603808 134300 3 None - 2 Rat 7.7 pKd = 7.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL214986 134300 3 None - 2 Rat 7.7 pKd = 7.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL36622 134300 3 None - 2 Rat 7.7 pKd = 7.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL3740374 134300 3 None - 2 Rat 7.7 pKd = 7.7 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
69781970 168130 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 477 5 1 8 4.0 COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4125981 168130 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 477 5 1 8 4.0 COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
52941981 24288 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 502 7 1 5 3.1 CN1C(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
CHEMBL1257883 24288 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 502 7 1 5 3.1 CN1C(=O)N(CC(O)CN2CCN(c3ccccc3F)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
10526831 118166 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 434 8 1 7 3.1 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ncco2)CC1 10.1021/jm970166j
CHEMBL327168 118166 0 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 434 8 1 7 3.1 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ncco2)CC1 10.1021/jm970166j
10789868 213509 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 453 10 1 6 4.0 COc1ccccc1N1CCN(CCCNc2ccncc2C(=O)N(C(C)C)C(C)C)CC1 10.1021/jm970166j
CHEMBL89916 213509 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 453 10 1 6 4.0 COc1ccccc1N1CCN(CCCNc2ccncc2C(=O)N(C(C)C)C(C)C)CC1 10.1021/jm970166j
44323554 213238 0 None - 0 Rat 5.6 pKd = 5.6 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 446 8 1 7 2.9 CN(C)C(=O)c1cccnc1N1CCC(NCCOc2ccccc2-c2cncnc2)CC1 10.1021/jm970166j
CHEMBL88109 213238 0 None - 0 Rat 5.6 pKd = 5.6 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 446 8 1 7 2.9 CN(C)C(=O)c1cccnc1N1CCC(NCCOc2ccccc2-c2cncnc2)CC1 10.1021/jm970166j
11994673 19088 0 None - 0 Rat 5.6 pKd = 5.6 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 419 7 1 5 4.5 COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL1185036 19088 0 None - 0 Rat 5.6 pKd = 5.6 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 419 7 1 5 4.5 COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL385371 19088 0 None - 0 Rat 5.6 pKd = 5.6 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 419 7 1 5 4.5 COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
132266 8061 12 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/s0960-894x(98)00217-0
486 8061 12 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/s0960-894x(98)00217-0
CHEMBL423294 8061 12 None - 0 Rat 7.6 pKd = 7.6 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/s0960-894x(98)00217-0
44586483 179246 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 600 11 1 8 3.3 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)N(C(C)C(=O)OC)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
CHEMBL448198 179246 0 None - 0 Rat 6.6 pKd = 6.6 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 600 11 1 8 3.3 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)N(C(C)C(=O)OC)C(=O)C2(c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2010.07.101
44586479 195406 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 572 10 1 8 2.6 COC(=O)CN1C(=O)N(CC(O)CN2CCN(c3ccccc3OC)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
CHEMBL503007 195406 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 572 10 1 8 2.6 COC(=O)CN1C(=O)N(CC(O)CN2CCN(c3ccccc3OC)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
2419 7482 28 None - 3 Rat 8.5 pKd = 8.5 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2011.04.032
9 7482 28 None - 3 Rat 8.5 pKd = 8.5 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2011.04.032
CHEMBL13647 7482 28 None - 3 Rat 8.5 pKd = 8.5 Functional
Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrAntagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2011.04.032
71462043 91343 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 379 8 1 6 3.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153555 91343 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 379 8 1 6 3.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2220895 91343 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 379 8 1 6 3.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1 10.1016/j.ejmech.2012.09.049
10506915 47013 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 552 13 1 9 4.5 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN4CCSC4)c3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL148061 47013 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 552 13 1 9 4.5 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN4CCSC4)c3)nc(N)c2cc1OC 10.1021/jm9810654
10745791 43283 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 579 19 3 9 4.6 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCN)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL144776 43283 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 579 19 3 9 4.6 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCN)nc(N)c2cc1OC 10.1021/jm9810654
10786203 214048 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 383 8 2 6 2.1 CNC(=O)c1cccnc1NCCCN1CCN(c2ccccc2OC)CC1 10.1021/jm970166j
CHEMBL93054 214048 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 383 8 2 6 2.1 CNC(=O)c1cccnc1NCCCN1CCN(c2ccccc2OC)CC1 10.1021/jm970166j
10651334 36524 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 607 20 2 9 5.2 CNCCCCCCN(C)Cc1ccc(C(=O)N(C)CCCCCCN(C)c2nc(N)c3cc(OC)c(OC)cc3n2)cc1 10.1021/jm9810654
CHEMBL138681 36524 0 None - 0 Rat 8.5 pKd = 8.5 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 607 20 2 9 5.2 CNCCCCCCN(C)Cc1ccc(C(=O)N(C)CCCCCCN(C)c2nc(N)c3cc(OC)c(OC)cc3n2)cc1 10.1021/jm9810654
10697270 112955 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 519 9 2 8 3.2 CNC(=O)c1cnc2c(c(C)nn2C)c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
CHEMBL313775 112955 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 519 9 2 8 3.2 CNC(=O)c1cnc2c(c(C)nn2C)c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
2419 7482 28 None - 3 Rat 8.4 pKd = 8.4 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm011066n
9 7482 28 None - 3 Rat 8.4 pKd = 8.4 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm011066n
CHEMBL13647 7482 28 None - 3 Rat 8.4 pKd = 8.4 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm011066n
10549680 119161 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 413 8 1 6 3.1 CSc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL329601 119161 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 413 8 1 6 3.1 CSc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10620831 213666 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 1 6 2.4 COc1ccccc1N1CCN(CCCNc2ccc(C(=O)N(C)C)cn2)CC1 10.1021/jm970166j
CHEMBL90778 213666 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 1 6 2.4 COc1ccccc1N1CCN(CCCNc2ccc(C(=O)N(C)C)cn2)CC1 10.1021/jm970166j
10596968 213757 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 0 5 3.0 COc1ccccc1N1CCN(CCCOc2ccccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL91338 213757 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 0 5 3.0 COc1ccccc1N1CCN(CCCOc2ccccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10764021 213770 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 409 9 1 5 3.4 CCCc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL91400 213770 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 409 9 1 5 3.4 CCCc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10574889 113323 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 435 7 1 5 3.4 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C(F)(F)F)CC1 10.1021/jm970166j
CHEMBL314114 113323 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 435 7 1 5 3.4 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C(F)(F)F)CC1 10.1021/jm970166j
10552704 170228 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 479 8 1 6 4.0 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C)cccc23)CC1 10.1021/jm970166j
CHEMBL419867 170228 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 479 8 1 6 4.0 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C)cccc23)CC1 10.1021/jm970166j
10624682 213817 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 483 8 1 8 2.8 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c2c(C)nn3C)CC1 10.1021/jm970166j
CHEMBL91605 213817 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 483 8 1 8 2.8 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c2c(C)nn3C)CC1 10.1021/jm970166j
44289262 108151 2 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 421 9 1 6 4.3 COc1cccc(OC)c1OCCNC[C@@H]1Oc2ccccc2O[C@H]1c1ccccc1 10.1021/jm011066n
CHEMBL297106 108151 2 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 421 9 1 6 4.3 COc1cccc(OC)c1OCCNC[C@@H]1Oc2ccccc2O[C@H]1c1ccccc1 10.1021/jm011066n
25022505 195070 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 586 10 1 8 2.9 COC(=O)C(C)N1C(=O)N(CC(O)CN2CCN(c3ccccc3OC)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
CHEMBL500266 195070 0 None - 0 Rat 6.5 pKd = 6.5 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 586 10 1 8 2.9 COC(=O)C(C)N1C(=O)N(CC(O)CN2CCN(c3ccccc3OC)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
44428848 99069 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 453 4 1 8 3.6 COc1cc2nc(N3CCN(C(=O)c4cccs4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL242724 99069 0 None - 0 Rat 7.5 pKd = 7.5 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 453 4 1 8 3.6 COc1cc2nc(N3CCN(C(=O)c4cccs4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
10447834 8714 4 None - 3 Rat 5.5 pKd = 5.5 Functional
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
ChEMBL 305 7 2 2 3.7 NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
4026 8714 4 None - 3 Rat 5.5 pKd = 5.5 Functional
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
ChEMBL 305 7 2 2 3.7 NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
CHEMBL275507 8714 4 None - 3 Rat 5.5 pKd = 5.5 Functional
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
ChEMBL 305 7 2 2 3.7 NCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
145975903 170600 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 412 8 1 6 2.6 COC(=O)Cc1ccc(OC[C@H](O)CN2CCN(c3cc(C)ccc3C)CC2)cc1 10.1016/j.bmcl.2018.01.068
CHEMBL4206260 170600 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 412 8 1 6 2.6 COC(=O)Cc1ccc(OC[C@H](O)CN2CCN(c3cc(C)ccc3C)CC2)cc1 10.1016/j.bmcl.2018.01.068
11795906 213845 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 411 8 1 6 2.7 COc1cc(C)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL91785 213845 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 411 8 1 6 2.7 COc1cc(C)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
44324012 214028 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 2 6 2.4 COc1ccccc1N1CCN(CCCNc2nc(C)cc(C)c2C(N)=O)CC1 10.1021/jm970166j
CHEMBL92901 214028 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 2 6 2.4 COc1ccccc1N1CCN(CCCNc2nc(C)cc(C)c2C(N)=O)CC1 10.1021/jm970166j
10505222 213444 0 None - 0 Rat 6.4 pKd = 6.4 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 490 8 1 7 3.6 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C#N)cccc23)CC1 10.1021/jm970166j
CHEMBL89397 213444 0 None - 0 Rat 6.4 pKd = 6.4 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 490 8 1 7 3.6 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C#N)cccc23)CC1 10.1021/jm970166j
11994797 19086 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 369 7 1 5 3.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)CCCC2 10.1021/jm060358r
CHEMBL1185017 19086 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 369 7 1 5 3.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)CCCC2 10.1021/jm060358r
CHEMBL383938 19086 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 369 7 1 5 3.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)CCCC2 10.1021/jm060358r
9976756 13379 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm021078o
CHEMBL1083181 13379 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm021078o
CHEMBL37883 13379 0 None - 0 Rat 8.4 pKd = 8.4 Functional
Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm021078o
2419 7482 28 None - 3 Rat 8.3 pKd = 8.3 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm9810654
9 7482 28 None - 3 Rat 8.3 pKd = 8.3 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm9810654
CHEMBL13647 7482 28 None - 3 Rat 8.3 pKd = 8.3 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm9810654
2419 7482 28 None - 3 Rat 8.3 pKd = 8.3 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(98)00217-0
9 7482 28 None - 3 Rat 8.3 pKd = 8.3 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(98)00217-0
CHEMBL13647 7482 28 None - 3 Rat 8.3 pKd = 8.3 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(98)00217-0
45268939 203439 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1021/jm8016046
CHEMBL564481 203439 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aortaAntagonist activity at rat Alpha-1D adrenoceptor assessed as inhibition if norepenephrine-induced contraction of thoracic aorta
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1021/jm8016046
11281005 18615 0 None - 0 Rat 5.4 pKd = 5.4 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 399 8 1 6 3.4 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL1182191 18615 0 None - 0 Rat 5.4 pKd = 5.4 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 399 8 1 6 3.4 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL218079 18615 0 None - 0 Rat 5.4 pKd = 5.4 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 399 8 1 6 3.4 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
52942591 24384 0 None - 0 Rat 5.4 pKd = 5.4 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 542 9 1 7 2.6 COC(=O)CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
CHEMBL1258228 24384 0 None - 0 Rat 5.4 pKd = 5.4 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 542 9 1 7 2.6 COC(=O)CN1C(=O)N(CC(O)CN2CCN(c3ccccc3)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
145964162 171115 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 412 8 1 6 2.6 COC(=O)Cc1ccc(OCC(O)CN2CCN(c3cc(C)ccc3C)CC2)cc1 10.1016/j.bmcl.2018.01.068
CHEMBL4212528 171115 0 None - 0 Rat 7.4 pKd = 7.4 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 412 8 1 6 2.6 COC(=O)Cc1ccc(OCC(O)CN2CCN(c3cc(C)ccc3C)CC2)cc1 10.1016/j.bmcl.2018.01.068
44277158 108422 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 449 11 3 10 3.0 COc1cc2nc(NCCSSCCNC(=O)c3ccco3)nc(N)c2cc1OC 10.1016/s0960-894x(98)00217-0
CHEMBL29907 108422 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from ratAntagonistic affinity against Alpha-1D adrenergic receptor was determined in isolated thoracic aorta from rat
ChEMBL 449 11 3 10 3.0 COc1cc2nc(NCCSSCCNC(=O)c3ccco3)nc(N)c2cc1OC 10.1016/s0960-894x(98)00217-0
10553687 45655 0 None - 0 Rat 8.3 pKd = 8.3 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 508 13 1 8 4.1 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CN(C)C)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL146724 45655 0 None - 0 Rat 8.3 pKd = 8.3 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 508 13 1 8 4.1 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CN(C)C)nc(N)c2cc1OC 10.1021/jm9810654
10097792 125367 0 None - 0 Rat 8.3 pKd = 8.3 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 508 13 1 8 4.1 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN(C)C)c3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL341665 125367 0 None - 0 Rat 8.3 pKd = 8.3 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 508 13 1 8 4.1 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN(C)C)c3)nc(N)c2cc1OC 10.1021/jm9810654
10621592 91346 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2c(OC)cccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153559 91346 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2c(OC)cccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2220898 91346 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2c(OC)cccc2O1 10.1016/j.ejmech.2012.09.049
10553385 125943 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 498 13 1 9 3.7 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CN(C)C)o3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL342997 125943 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 498 13 1 9 3.7 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CN(C)C)o3)nc(N)c2cc1OC 10.1021/jm9810654
44323803 213326 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 398 8 1 7 1.8 COc1ccccc1N1CCN(CCCNc2cncnc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL88633 213326 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 398 8 1 7 1.8 COc1ccccc1N1CCN(CCCNc2cncnc2C(=O)N(C)C)CC1 10.1021/jm970166j
10647341 213713 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 453 9 1 6 3.8 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC(C)(C)C)CC1 10.1021/jm970166j
CHEMBL91093 213713 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 453 9 1 6 3.8 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC(C)(C)C)CC1 10.1021/jm970166j
10524875 214151 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 1 6 2.4 COc1ccccc1N1CCN(CCCNc2ccncc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL93736 214151 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 397 8 1 6 2.4 COc1ccccc1N1CCN(CCCNc2ccncc2C(=O)N(C)C)CC1 10.1021/jm970166j
10815228 44042 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 499 12 1 7 4.7 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CCl)c3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL145384 44042 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 499 12 1 7 4.7 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CCl)c3)nc(N)c2cc1OC 10.1021/jm9810654
71454865 91378 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 361 8 2 7 2.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(O)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153551 91378 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 361 8 2 7 2.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(O)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2221145 91378 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 361 8 2 7 2.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(O)c2O1 10.1016/j.ejmech.2012.09.049
132266 8061 12 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2007.01.028
486 8061 12 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2007.01.028
CHEMBL423294 8061 12 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2007.01.028
132266 8061 12 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2018.05.023
486 8061 12 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2018.05.023
CHEMBL423294 8061 12 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2018.05.023
44244567 20809 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
ChEMBL 499 9 1 5 3.8 CCOc1ccccc1N1CCN(CC(O)CN2CCC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2009.04.028
CHEMBL1197380 20809 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
ChEMBL 499 9 1 5 3.8 CCOc1ccccc1N1CCN(CC(O)CN2CCC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2009.04.028
CHEMBL3216680 20809 0 None - 0 Rat 7.3 pKd = 7.3 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
ChEMBL 499 9 1 5 3.8 CCOc1ccccc1N1CCN(CC(O)CN2CCC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1016/j.ejmech.2009.04.028
10403687 9289 3 None - 2 Rat 5.2 pKd = 5.2 Functional
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
ChEMBL 319 8 2 2 3.9 CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
1205 9289 3 None - 2 Rat 5.2 pKd = 5.2 Functional
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
ChEMBL 319 8 2 2 3.9 CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
CHEMBL275035 9289 3 None - 2 Rat 5.2 pKd = 5.2 Functional
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
ChEMBL 319 8 2 2 3.9 CNCCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1 10.1021/jm991056a
44428845 149140 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL388884 149140 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
145962342 168202 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 521 9 0 8 5.1 CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@@H]3CCCC[C@@H]32)nc2cc(OC)c(OC)cc12 10.1016/j.bmc.2018.05.023
CHEMBL4126860 168202 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 521 9 0 8 5.1 CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@@H]3CCCC[C@@H]32)nc2cc(OC)c(OC)cc12 10.1016/j.bmc.2018.05.023
69782867 168362 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 549 8 1 9 4.4 COc1cc2nc(N3CCN(C(=O)COc4c(OC)cccc4C(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4129291 168362 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochlorideAntagonist activity at alpha1D adrenergic receptor in Wistar rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction measured after 30 mins in presence of cocaine hydrochloride and beta-adrenoceptor blocker propranolol hydrochloride
ChEMBL 549 8 1 9 4.4 COc1cc2nc(N3CCN(C(=O)COc4c(OC)cccc4C(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
10673882 45499 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 534 13 1 11 3.5 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccc(CN(C)C)o3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL146601 45499 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 534 13 1 11 3.5 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccc(CN(C)C)o3)nc(N)c2cc1OC 10.1021/jm9810654
10525639 213924 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 410 8 1 6 3.9 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)C(C)(C)C)CC1 10.1021/jm970166j
CHEMBL92261 213924 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 410 8 1 6 3.9 COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)C(C)(C)C)CC1 10.1021/jm970166j
10602797 43274 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 552 13 1 9 4.5 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CN4CCSC4)cc3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL144768 43274 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 552 13 1 9 4.5 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CN4CCSC4)cc3)nc(N)c2cc1OC 10.1021/jm9810654
10072518 42679 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 451 11 1 7 4.0 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL144224 42679 0 None - 0 Rat 8.2 pKd = 8.2 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 451 11 1 7 4.0 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3)nc(N)c2cc1OC 10.1021/jm9810654
50905588 63127 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
ChEMBL 406 7 2 6 2.1 COc1ccc(C[C@@H](C)NC[C@H]2Oc3ccccc3O[C@H]2C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
CHEMBL1630941 63127 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsAntagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 mins
ChEMBL 406 7 2 6 2.1 COc1ccc(C[C@@H](C)NC[C@H]2Oc3ccccc3O[C@H]2C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
11994667 18603 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 391 8 1 5 4.2 COc1ccc(-c2ccccc2)cc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182143 18603 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 391 8 1 5 4.2 COc1ccc(-c2ccccc2)cc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL214694 18603 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aortaActivity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta
ChEMBL 391 8 1 5 4.2 COc1ccc(-c2ccccc2)cc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
11133868 162121 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 435 9 1 5 5.4 COc1cccc(OC)c1OCCNC[C@H]1C[C@H](c2ccccc2)c2ccccc2S1 10.1021/jm011066n
CHEMBL40325 162121 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 435 9 1 5 5.4 COc1cccc(OC)c1OCCNC[C@H]1C[C@H](c2ccccc2)c2ccccc2S1 10.1021/jm011066n
10621790 170595 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 415 8 1 6 2.6 COc1cc(F)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL420620 170595 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 415 8 1 6 2.6 COc1cc(F)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10645210 213258 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 409 8 1 5 3.5 CC(C)c1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL88211 213258 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 409 8 1 5 3.5 CC(C)c1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10643699 213330 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 383 7 2 6 2.1 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2O)CC1 10.1021/jm970166j
CHEMBL88664 213330 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 383 7 2 6 2.1 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2O)CC1 10.1021/jm970166j
10716502 213354 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 410 7 1 5 2.5 COc1ccccc1N1CCN(CCC(=O)Nc2ccccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL88820 213354 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 410 7 1 5 2.5 COc1ccccc1N1CCN(CCC(=O)Nc2ccccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10555166 213497 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 575 9 1 8 4.5 CN(C)C(=O)c1cnc2c(c(C(C)(C)C)nn2C)c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
CHEMBL89822 213497 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 575 9 1 8 4.5 CN(C)C(=O)c1cnc2c(c(C(C)(C)C)nn2C)c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
10575254 213662 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 443 8 1 5 4.1 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1021/jm970166j
CHEMBL90746 213662 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 443 8 1 5 4.1 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ccccc2)CC1 10.1021/jm970166j
10552164 213679 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 466 9 1 6 3.4 CN(C)C(=O)c1cccnc1N1CCC(NCCOc2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
CHEMBL90869 213679 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 466 9 1 6 3.4 CN(C)C(=O)c1cccnc1N1CCC(NCCOc2ccccc2OCC(F)(F)F)CC1 10.1021/jm970166j
21473427 213756 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 410 8 1 5 3.3 COc1ccccc1N1CCN(CCCNc2c(C)cccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL91326 213756 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 410 8 1 5 3.3 COc1ccccc1N1CCN(CCCNc2c(C)cccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10621397 213871 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 407 8 1 5 3.3 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C2CC2)CC1 10.1021/jm970166j
CHEMBL91951 213871 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 407 8 1 5 3.3 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C2CC2)CC1 10.1021/jm970166j
9838192 118089 18 None - 3 Rat 6.2 pKd = 6.2 Functional
Antagonistic activity against Alpha-1D adrenergic receptor determined using phenylephrine challenge in rat aorta isolated tissues.Antagonistic activity against Alpha-1D adrenergic receptor determined using phenylephrine challenge in rat aorta isolated tissues.
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm025550h
CHEMBL326702 118089 18 None - 3 Rat 6.2 pKd = 6.2 Functional
Antagonistic activity against Alpha-1D adrenergic receptor determined using phenylephrine challenge in rat aorta isolated tissues.Antagonistic activity against Alpha-1D adrenergic receptor determined using phenylephrine challenge in rat aorta isolated tissues.
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm025550h
10814587 213671 0 None - 0 Rat 6.2 pKd = 6.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 480 8 1 7 3.4 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3nc(C)ccc23)CC1 10.1021/jm970166j
CHEMBL90810 213671 0 None - 0 Rat 6.2 pKd = 6.2 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 480 8 1 7 3.4 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3nc(C)ccc23)CC1 10.1021/jm970166j
9838192 118089 18 None - 3 Rat 6.2 pKd = 6.2 Functional
Antagonist activity at rat aorta adrenergic Alpha-1D receptorAntagonist activity at rat aorta adrenergic Alpha-1D receptor
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1016/j.bmc.2008.02.091
CHEMBL326702 118089 18 None - 3 Rat 6.2 pKd = 6.2 Functional
Antagonist activity at rat aorta adrenergic Alpha-1D receptorAntagonist activity at rat aorta adrenergic Alpha-1D receptor
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1016/j.bmc.2008.02.091
10787790 112767 0 None - 0 Rat 8.1 pKd = 8.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 411 9 1 6 2.8 CCOc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL313157 112767 0 None - 0 Rat 8.1 pKd = 8.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 411 9 1 6 2.8 CCOc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
11169638 23966 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 600 11 1 8 3.3 CCOC(=O)C(C)N1C(=O)N(CC(O)CN2CCN(c3ccccc3OC)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
CHEMBL1256344 23966 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Antagonist activity at adrenergic Alpha-1D receptor in rat aortaAntagonist activity at adrenergic Alpha-1D receptor in rat aorta
ChEMBL 600 11 1 8 3.3 CCOC(=O)C(C)N1C(=O)N(CC(O)CN2CCN(c3ccccc3OC)CC2)C(c2ccccc2)(c2ccccc2)C1=O 10.1016/j.bmcl.2010.07.101
145971621 171384 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 414 9 1 7 2.0 COC(=O)Cc1ccc(OCC(O)CN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmcl.2018.01.068
CHEMBL4215889 171384 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile responseAntagonist activity at alpha1D-adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as relaxation of (-)-noradrenaline-induced contractile response
ChEMBL 414 9 1 7 2.0 COC(=O)Cc1ccc(OCC(O)CN2CCN(c3ccccc3OC)CC2)cc1 10.1016/j.bmcl.2018.01.068
10042467 8208 1 None - 2 Rat 5.1 pKd = 5.1 Functional
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
ChEMBL 333 8 1 2 4.3 CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C 10.1021/jm991056a
1203 8208 1 None - 2 Rat 5.1 pKd = 5.1 Functional
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
ChEMBL 333 8 1 2 4.3 CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C 10.1021/jm991056a
CHEMBL11553 8208 1 None - 2 Rat 5.1 pKd = 5.1 Functional
Compound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of ratCompound was evaluated for its antagonist affinity towards Alpha-1D adrenergic receptor of rat
ChEMBL 333 8 1 2 4.3 CN(CCc1cnc([nH]1)CCC(c1ccccc1)c1ccccc1)C 10.1021/jm991056a
10743446 113848 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 483 8 1 8 2.8 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c2nc(C)n3C)CC1 10.1021/jm970166j
CHEMBL315785 113848 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 483 8 1 8 2.8 COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c2nc(C)n3C)CC1 10.1021/jm970166j
10787895 118197 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 413 8 2 7 2.1 COc1cc(O)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
CHEMBL327351 118197 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 413 8 2 7 2.1 COc1cc(O)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1 10.1021/jm970166j
10766280 118416 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 457 9 1 5 4.0 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2Cc2ccccc2)CC1 10.1021/jm970166j
CHEMBL328545 118416 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 457 9 1 5 4.0 CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2Cc2ccccc2)CC1 10.1021/jm970166j
10839699 213530 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 520 9 1 8 3.8 Cc1noc2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccccc4OCC(F)(F)F)CC3)c12 10.1021/jm970166j
CHEMBL90022 213530 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptorAntagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor
ChEMBL 520 9 1 8 3.8 Cc1noc2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccccc4OCC(F)(F)F)CC3)c12 10.1021/jm970166j
44428846 98964 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@@H]3CCCC[C@@H]32)o1 10.1016/j.bmc.2007.01.028
CHEMBL242508 98964 0 None - 0 Rat 7.1 pKd = 7.1 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@@H]3CCCC[C@@H]32)o1 10.1016/j.bmc.2007.01.028
10530133 43790 1 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 525 12 1 10 4.2 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccc(CCl)o3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL145181 43790 1 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.
ChEMBL 525 12 1 10 4.2 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccc(CCl)o3)nc(N)c2cc1OC 10.1021/jm9810654
10834793 91354 0 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 363 8 1 6 2.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153557 91354 0 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 363 8 1 6 2.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2220925 91354 0 None - 0 Rat 8.0 pKd = 8.0 Functional
Antagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 30 mins
ChEMBL 363 8 1 6 2.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1 10.1016/j.ejmech.2012.09.049
16721032 98963 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL242507 98963 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseAntagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
44289261 171691 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 417 9 1 4 5.1 COc1cccc(OC)c1OCCNCC1Cc2ccccc2C(c2ccccc2)C1 10.1021/jm011066n
CHEMBL42231 171691 0 None - 0 Rat 7.0 pKd = 7.0 Functional
Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorAntagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor
ChEMBL 417 9 1 4 5.1 COc1cccc(OC)c1OCCNCC1Cc2ccccc2C(c2ccccc2)C1 10.1021/jm011066n
53327991 70175 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation countingAntagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation counting
ChEMBL 449 8 0 5 3.7 COc1ccccc1N1CCN(CCCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796046 70175 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation countingAntagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation counting
ChEMBL 449 8 0 5 3.7 COc1ccccc1N1CCN(CCCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
53327748 70162 0 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation countingAntagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation counting
ChEMBL 435 8 0 5 3.5 COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796033 70162 0 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation countingAntagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation counting
ChEMBL 435 8 0 5 3.5 COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
44288917 107031 0 None - 0 Human 6.0 pKi = 6.0 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 510 7 2 4 4.0 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
CHEMBL288768 107031 0 None - 0 Human 6.0 pKi = 6.0 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 510 7 2 4 4.0 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
44288769 107925 0 None - 0 Human 5.9 pKi = 5.9 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 542 7 1 4 4.5 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
CHEMBL295395 107925 0 None - 0 Human 5.9 pKi = 5.9 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 542 7 1 4 4.5 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
9827677 175201 0 None - 0 Human 6.8 pKi = 6.8 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 510 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
CHEMBL43491 175201 0 None - 0 Human 6.8 pKi = 6.8 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 510 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
44288945 175694 0 None - 0 Human 6.7 pKi = 6.7 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 485 7 2 3 4.4 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
CHEMBL43860 175694 0 None - 0 Human 6.7 pKi = 6.7 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 485 7 2 3 4.4 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
44289100 106925 0 None - 0 Human 6.6 pKi = 6.6 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 499 7 1 3 4.7 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
CHEMBL287791 106925 0 None - 0 Human 6.6 pKi = 6.6 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 499 7 1 3 4.7 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
44289107 172959 0 None - 0 Human 6.5 pKi = 6.5 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 492 7 2 4 4.1 CC1=C(C(=O)NCCCN2CCC(c3ccccc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
CHEMBL42640 172959 0 None - 0 Human 6.5 pKi = 6.5 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 492 7 2 4 4.1 CC1=C(C(=O)NCCCN2CCC(c3ccccc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
53327992 70179 0 None - 0 Human 8.3 pKi = 8.3 Functional
Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation countingAntagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation counting
ChEMBL 461 7 0 5 3.6 COc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796050 70179 0 None - 0 Human 8.3 pKi = 8.3 Functional
Antagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation countingAntagonist activity against human cloned adrenergic Alpha-1D receptor expressed in HEK293 cells assessed as inhibition of norepinephrine-induced [3H]inositol phosphate hydrolysis by scintillation counting
ChEMBL 461 7 0 5 3.6 COc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
44288874 107872 0 None - 0 Human 6.2 pKi = 6.2 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 528 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
CHEMBL295001 107872 0 None - 0 Human 6.2 pKi = 6.2 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 528 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 10.1016/s0960-894x(99)00696-4
10436842 107032 0 None - 0 Human 6.2 pKi = 6.2 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 524 7 1 4 4.6 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
CHEMBL288772 107032 0 None - 0 Human 6.2 pKi = 6.2 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 524 7 1 4 4.6 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
44289103 162403 0 None - 0 Human 6.2 pKi = 6.2 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 506 7 1 4 4.4 CC1=C(C(=O)NCCCN2CCC(c3ccccc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
CHEMBL40464 162403 0 None - 0 Human 6.2 pKi = 6.2 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 506 7 1 4 4.4 CC1=C(C(=O)NCCCN2CCC(c3ccccc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
44289035 107290 0 None - 0 Human 6.1 pKi = 6.1 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 524 7 1 4 4.4 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
CHEMBL291166 107290 0 None - 0 Human 6.1 pKi = 6.1 Functional
In vitro antagonism at Alpha-1D adrenergic receptorIn vitro antagonism at Alpha-1D adrenergic receptor
ChEMBL 524 7 1 4 4.4 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C 10.1016/s0960-894x(99)00696-4
135398745 9688 112 None -38 33 Rat 6.4 pA2 = 6.4 Functional
Measured as antagonism of phenylephrine-induced contraction of endothelium-denuded rat aorta.Measured as antagonism of phenylephrine-induced contraction of endothelium-denuded rat aorta.
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 18542932
47 9688 112 None -38 33 Rat 6.4 pA2 = 6.4 Functional
Measured as antagonism of phenylephrine-induced contraction of endothelium-denuded rat aorta.Measured as antagonism of phenylephrine-induced contraction of endothelium-denuded rat aorta.
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 18542932
CHEMBL715 9688 112 None -38 33 Rat 6.4 pA2 = 6.4 Functional
Measured as antagonism of phenylephrine-induced contraction of endothelium-denuded rat aorta.Measured as antagonism of phenylephrine-induced contraction of endothelium-denuded rat aorta.
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 18542932
DB00334 9688 112 None -38 33 Rat 6.4 pA2 = 6.4 Functional
Measured as antagonism of phenylephrine-induced contraction of endothelium-denuded rat aorta.Measured as antagonism of phenylephrine-induced contraction of endothelium-denuded rat aorta.
Guide to Pharmacology 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C 18542932
1753 9282 28 None -2 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
483 9282 28 None -2 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
6082 9282 28 None -2 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
CHEMBL524 9282 28 None -2 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
DB00723 9282 28 None -2 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
13155 10195 0 None - 1 Rat 9.2 pEC50 = 9.2 Functional
Antagonist potency determined in isolated rat thoracic aortaAntagonist potency determined in isolated rat thoracic aorta
Guide to Pharmacology 668 12 2 9 4.5 CN(C(CCCC(=O)NC=1C=CC2=C(C1)C=3NC(N(C(C3S2)=O)CCN4CCN(CC4)C5=C(C=CC=C5)OC)=O)=O)CC6=CC=CC=C6 24992070
90645598 10195 0 None - 1 Rat 9.2 pEC50 = 9.2 Functional
Antagonist potency determined in isolated rat thoracic aortaAntagonist potency determined in isolated rat thoracic aorta
Guide to Pharmacology 668 12 2 9 4.5 CN(C(CCCC(=O)NC=1C=CC2=C(C1)C=3NC(N(C(C3S2)=O)CCN4CCN(CC4)C5=C(C=CC=C5)OC)=O)=O)CC6=CC=CC=C6 24992070
CHEMBL3297829 10195 0 None - 1 Rat 9.2 pEC50 = 9.2 Functional
Antagonist potency determined in isolated rat thoracic aortaAntagonist potency determined in isolated rat thoracic aorta
Guide to Pharmacology 668 12 2 9 4.5 CN(C(CCCC(=O)NC=1C=CC2=C(C1)C=3NC(N(C(C3S2)=O)CCN4CCN(CC4)C5=C(C=CC=C5)OC)=O)=O)CC6=CC=CC=C6 24992070
1753 9282 28 None -2 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
483 9282 28 None -2 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
6082 9282 28 None -2 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
CHEMBL524 9282 28 None -2 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
DB00723 9282 28 None -2 4 Human 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
2765 7730 19 None -28 7 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 34355529
515 7730 19 None -28 7 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 34355529
CHEMBL13852 7730 19 None -28 7 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 34355529
DB09202 7730 19 None -28 7 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 34355529
124 9755 47 None -501 25 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
2032 9755 47 None -501 25 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
4636 9755 47 None -501 25 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
CHEMBL762 9755 47 None -501 25 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
DB00935 9755 47 None -501 25 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
2146 9874 67 None -3 15 Human 6.7 pEC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
485 9874 67 None -3 15 Human 6.7 pEC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
6041 9874 67 None -3 15 Human 6.7 pEC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
CHEMBL1215 9874 67 None -3 15 Human 6.7 pEC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
DB00388 9874 67 None -3 15 Human 6.7 pEC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
1960 9632 67 None -5 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
439260 9632 67 None -5 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
505 9632 67 None -5 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
CHEMBL1437 9632 67 None -5 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
DB00368 9632 67 None -5 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
1028 7079 71 None -9 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
139148732 7079 71 None -9 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
479 7079 71 None -9 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
5816 7079 71 None -9 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
CHEMBL679 7079 71 None -9 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
DB00668 7079 71 None -9 19 Human 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
2146 9874 67 None -3 15 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O None
485 9874 67 None -3 15 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O None
6041 9874 67 None -3 15 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O None
CHEMBL1215 9874 67 None -3 15 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O None
DB00388 9874 67 None -3 15 Human 8.2 pIC50 = 8.2 Functional
NoneNone
Drug Central 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O None




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DOI

24900689 77138 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Binding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assayBinding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assay
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
CHEMBL1945039 77138 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Binding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assayBinding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assay
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
43260 12254 65 None -1 5 Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1007/s00044-004-0020-z
CHEMBL1076 12254 65 None -1 5 Rat 5.7 pEC50 = 5.7 Binding
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1007/s00044-004-0020-z
43260 12254 65 None -1 5 Rat 5.7 pEC50 = 5.7 Binding
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1021/jm025550h
CHEMBL1076 12254 65 None -1 5 Rat 5.7 pEC50 = 5.7 Binding
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1021/jm025550h
4038180 6992 14 None -141 8 Rat 5.6 pEC50 = 5.6 Binding
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
480 6992 14 None -141 8 Rat 5.6 pEC50 = 5.6 Binding
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
CHEMBL109783 6992 14 None -141 8 Rat 5.6 pEC50 = 5.6 Binding
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
4038180 6992 14 None -141 8 Rat 5.6 pEC50 = 5.6 Binding
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm025550h
480 6992 14 None -141 8 Rat 5.6 pEC50 = 5.6 Binding
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm025550h
CHEMBL109783 6992 14 None -141 8 Rat 5.6 pEC50 = 5.6 Binding
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm025550h
10297 33885 30 None -31 43 Rat 4.2 pEC50 = 4.2 Binding
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
ChEMBL 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 10.1021/jm025550h
CHEMBL136560 33885 30 None -31 43 Rat 4.2 pEC50 = 4.2 Binding
Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMEffective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM
ChEMBL 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 10.1021/jm025550h
162265 209053 22 None -5 44 Rat 4.1 pEC50 = 4.1 Binding
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1007/s00044-004-0020-z
4786 209053 22 None -5 44 Rat 4.1 pEC50 = 4.1 Binding
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1007/s00044-004-0020-z
CHEMBL61006 209053 22 None -5 44 Rat 4.1 pEC50 = 4.1 Binding
Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaAgonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1007/s00044-004-0020-z
4209 9937 75 None 1 33 Human 9.2 pIC50 = 9.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
4893 9937 75 None 1 33 Human 9.2 pIC50 = 9.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
503 9937 75 None 1 33 Human 9.2 pIC50 = 9.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
5385 9937 75 None 1 33 Human 9.2 pIC50 = 9.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
CHEMBL2 9937 75 None 1 33 Human 9.2 pIC50 = 9.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
DB00457 9937 75 None 1 33 Human 9.2 pIC50 = 9.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
4209 9937 75 None 1 33 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
4893 9937 75 None 1 33 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
503 9937 75 None 1 33 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
5385 9937 75 None 1 33 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
CHEMBL2 9937 75 None 1 33 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
DB00457 9937 75 None 1 33 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
2585 7590 103 None -4 22 Human 8.8 pIC50 = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
522 7590 103 None -4 22 Human 8.8 pIC50 = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
551 7590 103 None -4 22 Human 8.8 pIC50 = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
CHEMBL723 7590 103 None -4 22 Human 8.8 pIC50 = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
DB01136 7590 103 None -4 22 Human 8.8 pIC50 = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
6761 74574 19 None -1 18 Human 8.7 pIC50 = 8.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 nan
CHEMBL1909072 74574 19 None -1 18 Human 8.7 pIC50 = 8.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 nan
85469754 143673 0 None - 0 Human 8.0 pIC50 = 8 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 503 7 0 6 3.3 CS(=O)(=O)c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
CHEMBL3742276 143673 0 None - 0 Human 8.0 pIC50 = 8 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 503 7 0 6 3.3 CS(=O)(=O)c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
24901413 77131 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 516 11 6 6 4.3 Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12 10.1016/j.bmcl.2011.10.049
CHEMBL1945032 77131 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 516 11 6 6 4.3 Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12 10.1016/j.bmcl.2011.10.049
24900811 77139 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 10.1016/j.bmcl.2011.10.049
CHEMBL1945040 77139 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 10.1016/j.bmcl.2011.10.049
57391554 77143 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1cccc(CNCc2cccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)sc34)c2)c1 10.1016/j.bmcl.2011.10.049
CHEMBL1945044 77143 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1cccc(CNCc2cccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)sc34)c2)c1 10.1016/j.bmcl.2011.10.049
24900937 77159 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 413 8 4 6 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CN4CCCC4)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945294 77159 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 413 8 4 6 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CN4CCCC4)c3)c2s1 10.1016/j.bmcl.2011.10.049
102 10899 48 None -363 49 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
3659 10899 48 None -363 49 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
8969 10899 48 None -363 49 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
CHEMBL15245 10899 48 None -363 49 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
DB01392 10899 48 None -363 49 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
180 7189 56 None -23 40 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
200 7189 56 None -23 40 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
2160 7189 56 None -23 40 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
CHEMBL629 7189 56 None -23 40 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
DB00321 7189 56 None -23 40 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
85469871 143362 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 443 6 0 4 4.0 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3F)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3739505 143362 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 443 6 0 4 4.0 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3F)CC2)cc1 10.1016/j.bmc.2015.11.020
3151 8244 97 None -77 26 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
945 8244 97 None -77 26 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
965 8244 97 None -77 26 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
CHEMBL219916 8244 97 None -77 26 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
DB01184 8244 97 None -77 26 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
277 8083 62 None -42 50 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
2913 8083 62 None -42 50 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
765 8083 62 None -42 50 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
CHEMBL516 8083 62 None -42 50 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
DB00434 8083 62 None -42 50 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
2477 7532 59 None -8 29 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
36 7532 59 None -8 29 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
437 7532 59 None -8 29 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
CHEMBL49 7532 59 None -8 29 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
DB00490 7532 59 None -8 29 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
448537 167029 89 None -33 25 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 167029 89 None -33 25 Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
12488 8438 56 None -10 23 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
941361 8438 56 None -10 23 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
CHEMBL30008 8438 56 None -10 23 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
DB04841 8438 56 None -10 23 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
85469869 143369 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 426 6 0 5 3.2 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3739533 143369 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 426 6 0 5 3.2 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccn3)CC2)cc1 10.1016/j.bmc.2015.11.020
10015132 170648 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 253 4 1 4 2.1 c1ccc(-c2ccccc2OCC2=NCCN2)nc1 10.1016/s0960-894x(01)00764-8
CHEMBL420683 170648 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 253 4 1 4 2.1 c1ccc(-c2ccccc2OCC2=NCCN2)nc1 10.1016/s0960-894x(01)00764-8
196129 74573 17 None -691 15 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC nan
CHEMBL1909065 74573 17 None -691 15 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC nan
36811 8236 37 None 1 7 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
535 8236 37 None 1 7 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
937 8236 37 None 1 7 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
CHEMBL926 8236 37 None 1 7 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
DB00841 8236 37 None 1 7 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
85469808 143408 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 439 7 0 4 3.8 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(Cc3ccccc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3739900 143408 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 439 7 0 4 3.8 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(Cc3ccccc3)CC2)cc1 10.1016/j.bmc.2015.11.020
1547484 7727 74 None -9 20 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
654 7727 74 None -9 20 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
9072 7727 74 None -9 20 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL43064 7727 74 None -9 20 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
DB00568 7727 74 None -9 20 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
22493392 53929 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 252 4 2 4 2.2 c1ccc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
CHEMBL154298 53929 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 252 4 2 4 2.2 c1ccc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
3158 63041 27 None -398 20 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 nan
CHEMBL1628227 63041 27 None -398 20 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 nan
2142 9870 58 None -5 37 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
4920903 9870 58 None -5 37 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
502 9870 58 None -5 37 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
5775 9870 58 None -5 37 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
CHEMBL597 9870 58 None -5 37 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
DB00692 9870 58 None -5 37 Human 7.9 pIC50 = 7.9 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
24901347 77108 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 463 11 5 6 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4)cc3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1944695 77108 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 463 11 5 6 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4)cc3)c2s1 10.1016/j.bmcl.2011.10.049
85469931 143670 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 493 6 0 4 4.9 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3742253 143670 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 493 6 0 4 4.9 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
2803 7742 58 None -12 19 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
516 7742 58 None -12 19 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
704 7742 58 None -12 19 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
CHEMBL134 7742 58 None -12 19 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
DB00575 7742 58 None -12 19 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
6726 8063 51 None -11 13 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
7151 8063 51 None -11 13 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
749 8063 51 None -11 13 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL648 8063 51 None -11 13 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
DB01176 8063 51 None -11 13 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
85469934 143513 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 443 6 0 4 4.0 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3740847 143513 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 443 6 0 4 4.0 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(F)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
85469932 143564 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 455 7 0 5 3.9 COc1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
CHEMBL3741318 143564 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 455 7 0 5 3.9 COc1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
24901144 77104 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1944691 77104 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
2284 9956 33 None -3 29 Human 7.9 pIC50 = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
4926 9956 33 None -3 29 Human 7.9 pIC50 = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
7281 9956 33 None -3 29 Human 7.9 pIC50 = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
CHEMBL564 9956 33 None -3 29 Human 7.9 pIC50 = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
DB00420 9956 33 None -3 29 Human 7.9 pIC50 = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
174174 7311 49 None -2041 14 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
260 7311 49 None -2041 14 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
320 7311 49 None -2041 14 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
CHEMBL517712 7311 49 None -2041 14 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
DB00572 7311 49 None -2041 14 Human 5.9 pIC50 = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
133 9274 52 None -41 43 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 9274 52 None -41 43 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 9274 52 None -41 43 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 9274 52 None -41 43 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 9274 52 None -41 43 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
6075 156887 42 None -4 16 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 nan
CHEMBL395110 156887 42 None -4 16 Human 6.9 pIC50 = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 nan
16220269 196439 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of adrenergic Alpha-1D receptorInhibition of adrenergic Alpha-1D receptor
ChEMBL 361 3 1 2 4.4 CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O 10.1073/pnas.0605125104
CHEMBL515170 196439 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of adrenergic Alpha-1D receptorInhibition of adrenergic Alpha-1D receptor
ChEMBL 361 3 1 2 4.4 CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O 10.1073/pnas.0605125104
44362511 126126 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 267 4 1 4 2.4 Cc1ccnc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL344294 126126 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 267 4 1 4 2.4 Cc1ccnc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
441383 27105 57 None -9 17 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL1306 27105 57 None -9 17 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
10378649 115370 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 274 7 3 4 1.6 CCCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL320419 115370 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 274 7 3 4 1.6 CCCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
2812 11551 101 None -40 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -40 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
2105 9828 37 None -72 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
47811 9828 37 None -72 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
48 9828 37 None -72 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
CHEMBL531 9828 37 None -72 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
DB01186 9828 37 None -72 32 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
19063108 100259 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
ChEMBL 546 9 1 10 4.6 COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2c2nc(N)c3cc(OC)c(OC)cc3n2)cc1OC 10.1021/jm960697s
CHEMBL24619 100259 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
ChEMBL 546 9 1 10 4.6 COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2c2nc(N)c3cc(OC)c(OC)cc3n2)cc1OC 10.1021/jm960697s
24900426 77136 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 477 12 5 6 3.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCCc4ccccc4)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945037 77136 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 477 12 5 6 3.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCCc4ccccc4)c3)c2s1 10.1016/j.bmcl.2011.10.049
24901143 77140 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 483 10 5 6 4.1 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCc4ccccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945041 77140 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 483 10 5 6 4.1 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCc4ccccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
24900750 77154 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1ccc(CNCc2cccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)sc34)c2)cc1 10.1016/j.bmcl.2011.10.049
CHEMBL1945289 77154 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1ccc(CNCc2cccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)sc34)c2)cc1 10.1016/j.bmcl.2011.10.049
127041710 143394 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 450 6 0 4 4.4 [C-]#[N+]c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
CHEMBL3739762 143394 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 450 6 0 4 4.4 [C-]#[N+]c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
85469873 143370 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 493 6 0 4 4.9 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3C(F)(F)F)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3739542 143370 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 493 6 0 4 4.9 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3C(F)(F)F)CC2)cc1 10.1016/j.bmc.2015.11.020
10199052 214733 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 258 5 3 4 1.0 O=C(NC1CC1)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL97044 214733 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 258 5 3 4 1.0 O=C(NC1CC1)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
3584 10549 64 None -1 14 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
5401 10549 64 None -1 14 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
7302 10549 64 None -1 14 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
CHEMBL611 10549 64 None -1 14 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
DB01162 10549 64 None -1 14 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
2435 7509 100 None -28 12 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
395 7509 100 None -28 12 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
520 7509 100 None -28 12 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
5386 7509 100 None -28 12 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
CHEMBL844 7509 100 None -28 12 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
DB00484 7509 100 None -28 12 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
85469698 143604 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 425 6 0 4 3.8 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3741658 143604 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 425 6 0 4 3.8 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3)CC2)cc1 10.1016/j.bmc.2015.11.020
3191 109635 97 None -14 25 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL305660 109635 97 None -14 25 Human 5.8 pIC50 = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
73453 36389 24 None -12 17 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 36389 24 None -12 17 Human 7.8 pIC50 = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
2398 7741 62 None -1 29 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
2801 7741 62 None -1 29 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
701 7741 62 None -1 29 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
CHEMBL415 7741 62 None -1 29 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
DB01242 7741 62 None -1 29 Human 6.8 pIC50 = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
2286 9957 51 None -8 30 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
4927 9957 51 None -8 30 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
7282 9957 51 None -8 30 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
CHEMBL643 9957 51 None -8 30 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
DB01069 9957 51 None -8 30 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
85469756 143365 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 455 7 0 5 3.9 COc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3739513 143365 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 455 7 0 5 3.9 COc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
240 7731 43 None -5 25 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
2769 7731 43 None -5 25 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
44279790 7731 43 None -5 25 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
660 7731 43 None -5 25 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
CHEMBL1729 7731 43 None -5 25 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
CHEMBL560739 7731 43 None -5 25 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
DB00604 7731 43 None -5 25 Human 6.7 pIC50 = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
11108001 17644 2 None 3 6 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL117248 17644 2 None 3 6 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL540542 17644 2 None 3 6 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
11057 182928 23 None -2 20 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 182928 23 None -2 20 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 182928 23 None -2 20 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 182928 23 None -2 20 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
24900685 77132 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 464 11 5 7 2.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccn4)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945033 77132 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 464 11 5 7 2.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccn4)c3)c2s1 10.1016/j.bmcl.2011.10.049
24901416 77134 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccccc3CNCCc3ccccc3F)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945035 77134 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccccc3CNCCc3ccccc3F)c2s1 10.1016/j.bmcl.2011.10.049
24900689 77138 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
CHEMBL1945039 77138 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
44329797 114883 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 261 5 2 5 1.7 CC(C)OC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL319553 114883 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 261 5 2 5 1.7 CC(C)OC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
122179430 128219 0 None -3 3 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 599 8 1 13 2.7 CCN(CC)c1ccc2cc(-n3cc(C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 10.1021/ml5004298
CHEMBL3582270 128219 0 None -3 3 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 599 8 1 13 2.7 CCN(CC)c1ccc2cc(-n3cc(C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 10.1021/ml5004298
42636941 185728 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]prazosin form human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]prazosin form human recombinant Alpha-1D adrenergic receptor
ChEMBL 343 5 0 5 4.4 CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 10.1016/j.bmc.2008.11.045
CHEMBL470432 185728 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]prazosin form human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]prazosin form human recombinant Alpha-1D adrenergic receptor
ChEMBL 343 5 0 5 4.4 CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1 10.1016/j.bmc.2008.11.045
237 211644 48 None -1 13 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL546257 211644 48 None -1 13 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL554190 211644 48 None -1 13 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL7568 211644 48 None -1 13 Human 5.7 pIC50 = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
2142 9870 58 None -5 37 Human 7.7 pIC50 = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
4920903 9870 58 None -5 37 Human 7.7 pIC50 = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
502 9870 58 None -5 37 Human 7.7 pIC50 = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
5775 9870 58 None -5 37 Human 7.7 pIC50 = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
CHEMBL597 9870 58 None -5 37 Human 7.7 pIC50 = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
DB00692 9870 58 None -5 37 Human 7.7 pIC50 = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
8459 10071 4 None - 3 Rat 7.6 pIC50 = 7.6 Binding
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
ChEMBL 495 8 1 9 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C 10.1021/jm960697s
9891980 10071 4 None - 3 Rat 7.6 pIC50 = 7.6 Binding
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
ChEMBL 495 8 1 9 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C 10.1021/jm960697s
CHEMBL430717 10071 4 None - 3 Rat 7.6 pIC50 = 7.6 Binding
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
ChEMBL 495 8 1 9 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C 10.1021/jm960697s
25014630 90314 1 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of alpha1D adrenergic receptorInhibition of alpha1D adrenergic receptor
ChEMBL 326 3 3 4 3.3 N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1 10.1016/j.ejmech.2012.07.006
CHEMBL2203713 90314 1 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of alpha1D adrenergic receptorInhibition of alpha1D adrenergic receptor
ChEMBL 326 3 3 4 3.3 N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1 10.1016/j.ejmech.2012.07.006
85469812 143464 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 469 8 0 5 4.2 CCOc1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
CHEMBL3740351 143464 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 469 8 0 5 4.2 CCOc1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
16738927 77133 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 464 11 5 7 2.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccn4)cc3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945034 77133 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 464 11 5 7 2.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccn4)cc3)c2s1 10.1016/j.bmcl.2011.10.049
57400229 77163 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 497 12 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCOc3cccc(CNCCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945298 77163 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 497 12 5 7 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCOc3cccc(CNCCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
24900942 77164 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 12 5 7 3.5 COc1ccccc1CNCCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
CHEMBL1945299 77164 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 12 5 7 3.5 COc1ccccc1CNCCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
24900872 77137 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 478 12 5 7 3.3 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCCc4ccccn4)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945038 77137 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 478 12 5 7 3.3 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCCc4ccccn4)c3)c2s1 10.1016/j.bmcl.2011.10.049
24900749 77156 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 11 4 7 3.8 COc1ccccc1CN(C)Cc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
CHEMBL1945291 77156 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 11 4 7 3.8 COc1ccccc1CN(C)Cc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
44362185 127807 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 253 4 1 4 2.1 c1cncc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL356605 127807 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 253 4 1 4 2.1 c1cncc(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
57469 25638 125 None 1 3 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 240 2 1 4 2.8 CC(C)Cn1cnc2c(N)nc3ccccc3c21 nan
CHEMBL1282 25638 125 None 1 3 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 240 2 1 4 2.8 CC(C)Cn1cnc2c(N)nc3ccccc3c21 nan
213 10625 55 None -4 43 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
2717 10625 55 None -4 43 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
5533 10625 55 None -4 43 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
CHEMBL621 10625 55 None -4 43 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
DB00656 10625 55 None -4 43 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
5624 39467 14 None -39 10 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 520 5 1 8 4.2 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 nan
CHEMBL1203324 39467 14 None -39 10 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 520 5 1 8 4.2 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 nan
CHEMBL141343 39467 14 None -39 10 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 520 5 1 8 4.2 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 nan
1971 9641 38 None -6 30 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
2404 9641 38 None -6 30 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
4543 9641 38 None -6 30 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
CHEMBL445 9641 38 None -6 30 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
DB00540 9641 38 None -6 30 Human 6.6 pIC50 = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
124 9755 47 None -524 32 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
2032 9755 47 None -524 32 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
4636 9755 47 None -524 32 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
CHEMBL762 9755 47 None -524 32 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
DB00935 9755 47 None -524 32 Human 5.6 pIC50 = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
10660 21188 58 None -38 12 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 469 6 1 7 3.0 CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O nan
CHEMBL1200406 21188 58 None -38 12 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 469 6 1 7 3.0 CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O nan
10531 8202 21 None -28 24 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
121 8202 21 None -28 24 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
888 8202 21 None -28 24 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
CHEMBL1732 8202 21 None -28 24 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
DB00320 8202 21 None -28 24 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
9794803 17778 2 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 242 4 2 5 1.8 c1ccc(-c2cnco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL117381 17778 2 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 242 4 2 5 1.8 c1ccc(-c2cnco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
3157 8252 71 None -1 12 Human 8.5 pIC50 = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
7170 8252 71 None -1 12 Human 8.5 pIC50 = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
954 8252 71 None -1 12 Human 8.5 pIC50 = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
CHEMBL707 8252 71 None -1 12 Human 8.5 pIC50 = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
DB00590 8252 71 None -1 12 Human 8.5 pIC50 = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
2726 7706 68 None 1 72 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
621 7706 68 None 1 72 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
83 7706 68 None 1 72 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
CHEMBL71 7706 68 None 1 72 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
DB00477 7706 68 None 1 72 Human 8.4 pIC50 = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
31101 7516 40 None -7 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
35 7516 40 None -7 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
403 7516 40 None -7 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
CHEMBL493 7516 40 None -7 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
DB01200 7516 40 None -7 35 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
4189 213701 96 None -18 34 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -18 34 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -18 34 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
191 7191 98 None -23 29 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
201 7191 98 None -23 29 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
2170 7191 98 None -23 29 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
CHEMBL1113 7191 98 None -23 29 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
DB00543 7191 98 None -23 29 Human 6.5 pIC50 = 6.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
85469930 143652 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 473 6 0 4 4.8 Cc1ccc(Cl)cc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
CHEMBL3742103 143652 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 473 6 0 4 4.8 Cc1ccc(Cl)cc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
57398562 77135 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 477 11 5 6 4.1 CC(CNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1 10.1016/j.bmcl.2011.10.049
CHEMBL1945036 77135 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 477 11 5 6 4.1 CC(CNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1 10.1016/j.bmcl.2011.10.049
24900751 77155 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 12 5 7 3.8 CCOc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
CHEMBL1945290 77155 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 12 5 7 3.8 CCOc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
24900812 77142 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 450 10 5 7 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCc4ccccn4)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945043 77142 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 450 10 5 7 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCc4ccccn4)c3)c2s1 10.1016/j.bmcl.2011.10.049
26987 7736 33 None -39 21 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
6063 7736 33 None -39 21 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
671 7736 33 None -39 21 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
CHEMBL1626 7736 33 None -39 21 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
DB00283 7736 33 None -39 21 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
44269124 35591 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 252 4 1 3 2.7 c1ccc(-c2ccccc2OCC2=NCCN2)cc1 10.1016/s0960-894x(01)00764-8
CHEMBL13789 35591 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 252 4 1 3 2.7 c1ccc(-c2ccccc2OCC2=NCCN2)cc1 10.1016/s0960-894x(01)00764-8
2771 201796 74 None -9 27 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 nan
CHEMBL1200781 201796 74 None -9 27 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 nan
CHEMBL549 201796 74 None -9 27 Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 nan
1212 8443 50 None -18 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 8443 50 None -18 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 8443 50 None -18 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 8443 50 None -18 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 8443 50 None -18 65 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
1210 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
1213 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
2725 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
33036 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
4411 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
616 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
6976 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
716121 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL1201353 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL1554789 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL505 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
DB01114 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
DB13679 7705 51 None -602 21 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
2274 9947 58 None -5 31 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
4917 9947 58 None -5 31 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
7279 9947 58 None -5 31 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
CHEMBL728 9947 58 None -5 31 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
DB00433 9947 58 None -5 31 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
56961507 128220 0 None -4 3 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 678 6 4 11 5.0 COc1cc2nc(N3CCN(C(=S)Nc4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)CC3)nc(N)c2cc1OC 10.1021/ml5004298
CHEMBL3582271 128220 0 None -4 3 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 678 6 4 11 5.0 COc1cc2nc(N3CCN(C(=S)Nc4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)CC3)nc(N)c2cc1OC 10.1021/ml5004298
85469933 143426 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 439 6 0 4 4.2 Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3740019 143426 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 439 6 0 4 4.2 Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
22493269 53600 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 256 4 2 5 2.1 Cc1ncoc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL154023 53600 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 256 4 2 5 2.1 Cc1ncoc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
135398737 7745 93 None -2 90 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
38 7745 93 None -2 90 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
722 7745 93 None -2 90 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
CHEMBL42 7745 93 None -2 90 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
DB00363 7745 93 None -2 90 Human 7.5 pIC50 = 7.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
85469872 143583 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 459 6 0 4 4.5 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3741483 143583 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 459 6 0 4 4.5 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
85469811 143662 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 459 6 0 4 4.5 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3Cl)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3742198 143662 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 459 6 0 4 4.5 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3Cl)CC2)cc1 10.1016/j.bmc.2015.11.020
1530 8963 50 None -104 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
3827 8963 50 None -104 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
7206 8963 50 None -104 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
CHEMBL534 8963 50 None -104 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
DB00920 8963 50 None -104 21 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
22493280 55049 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ccno2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL155327 55049 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ccno2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
24901284 77161 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 545 12 5 6 5.2 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCc3cccc(CNCCc4c(Cl)cccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945296 77161 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 545 12 5 6 5.2 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCc3cccc(CNCCc4c(Cl)cccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
24901285 77162 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 545 11 5 6 5.2 CC(Cc1cccc(CNCCc2c(Cl)cccc2Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12 10.1016/j.bmcl.2011.10.049
CHEMBL1945297 77162 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 545 11 5 6 5.2 CC(Cc1cccc(CNCCc2c(Cl)cccc2Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12 10.1016/j.bmcl.2011.10.049
22493258 105440 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against radioligand binding to human aAlpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human aAlpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
CHEMBL277375 105440 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against radioligand binding to human aAlpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human aAlpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 241 4 3 4 1.5 c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(03)00050-7
4011 89183 49 None -19 24 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 nan
CHEMBL21731 89183 49 None -19 24 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 nan
24901209 77130 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 516 11 6 6 4.3 Cc1cccc2c(CCNCc3cccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)c3)c[nH]c12 10.1016/j.bmcl.2011.10.049
CHEMBL1945031 77130 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 516 11 6 6 4.3 Cc1cccc2c(CCNCc3cccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)c3)c[nH]c12 10.1016/j.bmcl.2011.10.049
57401435 77175 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 458 11 5 6 2.8 O=c1ccc2c([C@@H](O)CNCCc3cccc(CNCCc4ccccn4)c3)ccc(O)c2[nH]1 10.1016/j.bmcl.2011.10.049
CHEMBL1945503 77175 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 458 11 5 6 2.8 O=c1ccc2c([C@@H](O)CNCCc3cccc(CNCCc4ccccn4)c3)ccc(O)c2[nH]1 10.1016/j.bmcl.2011.10.049
22493352 55048 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ncco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
CHEMBL155326 55048 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 242 4 2 5 1.8 c1ccc(-c2ncco2)c(NCC2=NCCN2)c1 10.1016/s0960-894x(01)00822-8
1588 9105 27 None -20 44 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
28864 9105 27 None -20 44 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
43 9105 27 None -20 44 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
CHEMBL157138 9105 27 None -20 44 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
DB00589 9105 27 None -20 44 Human 7.4 pIC50 = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
10060965 42008 1 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 256 4 1 4 2.6 Cc1ccoc1-c1ccccc1OCC1=NCCN1 10.1016/s0960-894x(01)00764-8
CHEMBL143562 42008 1 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 256 4 1 4 2.6 Cc1ccoc1-c1ccccc1OCC1=NCCN1 10.1016/s0960-894x(01)00764-8
22493289 56462 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 253 4 2 5 1.6 c1cnc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
CHEMBL156661 56462 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 253 4 2 5 1.6 c1cnc(-c2ccccc2NCC2=NCCN2)nc1 10.1016/s0960-894x(01)00822-8
10399043 126940 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 232 5 2 5 1.1 CO/N=C/c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
CHEMBL351542 126940 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblastsIn vitro binding affinity against human Alpha-1D adrenergic receptor expressed in rat-1 fibroblasts
ChEMBL 232 5 2 5 1.1 CO/N=C/c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00822-8
1028 7079 71 None -17 30 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
139148732 7079 71 None -17 30 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
479 7079 71 None -17 30 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
5816 7079 71 None -17 30 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
CHEMBL679 7079 71 None -17 30 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
DB00668 7079 71 None -17 30 Human 6.4 pIC50 = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
122179431 128221 0 None 1 3 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 585 9 1 13 3.1 CCN(CC)c1ccc2cc(-n3cc(CN4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 10.1021/ml5004298
CHEMBL3582272 128221 0 None 1 3 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 585 9 1 13 3.1 CCN(CC)c1ccc2cc(-n3cc(CN4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 10.1021/ml5004298
3952 8669 38 None -6 12 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5353646 8669 38 None -6 12 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5443 8669 38 None -6 12 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5702063 8669 38 None -6 12 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
CHEMBL1331786 8669 38 None -6 12 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
CHEMBL420 8669 38 None -6 12 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
3652 53018 70 None 1 9 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 nan
CHEMBL1535 53018 70 None 1 9 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 nan
134551 7146 27 None -10 21 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
271 7146 27 None -10 21 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
885 7146 27 None -10 21 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
CHEMBL1403281 7146 27 None -10 21 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
1043 8363 14 None -263 29 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
149 8363 14 None -263 29 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
8223 8363 14 None -263 29 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
CHEMBL442 8363 14 None -263 29 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
DB00696 8363 14 None -263 29 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
85469755 143547 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 461 6 0 4 4.1 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(F)cc3F)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3741161 143547 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 461 6 0 4 4.1 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(F)cc3F)CC2)cc1 10.1016/j.bmc.2015.11.020
1016 10519 78 None -22 35 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 10519 78 None -22 35 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 10519 78 None -22 35 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 10519 78 None -22 35 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 10519 78 None -22 35 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 10519 78 None -22 35 Human 5.3 pIC50 = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
100 10577 58 None -1 54 Human 8.2 pIC50 = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
2637 10577 58 None -1 54 Human 8.2 pIC50 = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
5452 10577 58 None -1 54 Human 8.2 pIC50 = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
CHEMBL479 10577 58 None -1 54 Human 8.2 pIC50 = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
DB00679 10577 58 None -1 54 Human 8.2 pIC50 = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
24901210 77103 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 497 11 5 6 4.1 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1944690 77103 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 497 11 5 6 4.1 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
24901349 77105 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4F)cc3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1944692 77105 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4F)cc3)c2s1 10.1016/j.bmcl.2011.10.049
24901283 77157 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 417 11 5 7 1.9 COCCNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
CHEMBL1945292 77157 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 417 11 5 7 1.9 COCCNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
57395043 77166 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 420 12 5 5 3.1 OCc1cc([C@@H](O)CNCCc2ccc(CNCCc3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.10.049
CHEMBL1945300 77166 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 420 12 5 5 3.1 OCc1cc([C@@H](O)CNCCc2ccc(CNCCc3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.10.049
9837963 69745 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory concentration against radioligand binding to human Alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human Alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
CHEMBL17851 69745 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory concentration against radioligand binding to human Alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human Alpha-1D adrenergic receptor, expressed in rat 1 fibroblast cells
ChEMBL 255 4 2 5 1.5 Cn1nccc1-c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(03)00050-7
9795167 114271 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 260 6 3 4 1.2 CCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
CHEMBL318544 114271 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 260 6 3 4 1.2 CCCNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(02)00753-9
1201549 7384 24 None -12 20 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
333 7384 24 None -12 20 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
7601 7384 24 None -12 20 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
CHEMBL1201203 7384 24 None -12 20 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
CHEMBL438151 7384 24 None -12 20 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
DB00245 7384 24 None -12 20 Human 7.3 pIC50 = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
1531 9046 69 None -14 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
3869 9046 69 None -14 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
7207 9046 69 None -14 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
CHEMBL429 9046 69 None -14 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
DB00598 9046 69 None -14 16 Human 6.3 pIC50 = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
44362195 127867 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 241 4 2 3 2.1 c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
CHEMBL357129 127867 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranesBinding affinity of compound towards human Alpha-1D adrenergic receptor expressed in rat-1 fibroblast membranes
ChEMBL 241 4 2 3 2.1 c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1 10.1016/s0960-894x(01)00764-8
44269124 35591 1 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 252 4 1 3 2.7 c1ccc(-c2ccccc2OCC2=NCCN2)cc1 10.1016/s0960-894x(02)00753-9
CHEMBL13789 35591 1 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 252 4 1 3 2.7 c1ccc(-c2ccccc2OCC2=NCCN2)cc1 10.1016/s0960-894x(02)00753-9
4418 40996 85 None 1 7 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmc.2015.11.020
CHEMBL142635 40996 85 None 1 7 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmc.2015.11.020
16215415 194111 1 None -3 5 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned adrenergic Alpha-1D receptorInhibition of cloned adrenergic Alpha-1D receptor
ChEMBL 471 9 2 3 3.8 CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br 10.1021/np800339e
CHEMBL493091 194111 1 None -3 5 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned adrenergic Alpha-1D receptorInhibition of cloned adrenergic Alpha-1D receptor
ChEMBL 471 9 2 3 3.8 CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br 10.1021/np800339e
44343410 18327 2 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 219 4 2 3 2.7 CSc1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
CHEMBL118055 18327 2 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 219 4 2 3 2.7 CSc1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
24901141 77314 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 531 11 5 6 4.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4c(Cl)cccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1947157 77314 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 531 11 5 6 4.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4c(Cl)cccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
85469868 143558 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 450 6 0 5 3.7 N#Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3741260 143558 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 450 6 0 5 3.7 N#Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
24900874 77158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 417 11 5 7 1.9 COCCNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 10.1016/j.bmcl.2011.10.049
CHEMBL1945293 77158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 417 11 5 7 1.9 COCCNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 10.1016/j.bmcl.2011.10.049
9816986 170918 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 274 6 2 4 1.6 CCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL421011 170918 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 274 6 2 4 1.6 CCN(CC)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
9903313 179457 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 260 5 2 4 1.2 CCN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL450018 179457 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 260 5 2 4 1.2 CCN(C)C(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
107715 207724 22 None -13 20 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL1255837 207724 22 None -13 20 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL601773 207724 22 None -13 20 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
24901351 77107 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 12 5 7 3.5 COc1ccccc1CCNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 10.1016/j.bmcl.2011.10.049
CHEMBL1944694 77107 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 12 5 7 3.5 COc1ccccc1CCNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 10.1016/j.bmcl.2011.10.049
85469753 143539 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 503 6 0 4 4.6 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(Br)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3741079 143539 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 503 6 0 4 4.6 O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(Br)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
2247 7293 81 None -31 42 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 7293 81 None -31 42 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 7293 81 None -31 42 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 7293 81 None -31 42 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 7293 81 None -31 42 Human 6.1 pIC50 = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
24901348 77102 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 531 11 5 6 4.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4c(Cl)cccc4Cl)cc3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1944689 77102 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 531 11 5 6 4.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4c(Cl)cccc4Cl)cc3)c2s1 10.1016/j.bmcl.2011.10.049
24901211 77106 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 12 5 7 3.5 COc1ccccc1CCNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
CHEMBL1944693 77106 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 493 12 5 7 3.5 COc1ccccc1CCNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 10.1016/j.bmcl.2011.10.049
24900813 77141 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 467 10 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945042 77141 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 467 10 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
57401436 77176 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1ccc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 10.1016/j.bmcl.2011.10.049
CHEMBL1945504 77176 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptorDisplacement of radiolabeled Prazosin from alpha1D adrenoceptor
ChEMBL 479 11 5 7 3.5 COc1ccccc1CNCc1ccc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 10.1016/j.bmcl.2011.10.049
3033538 8101 39 None 1 9 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
7155 8101 39 None 1 9 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
781 8101 39 None 1 9 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
CHEMBL1201216 8101 39 None 1 9 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
DB00298 8101 39 None 1 9 Human 8.1 pIC50 = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
118112300 162773 18 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at alpha1D-adrenergic receptor (unknown origin)Antagonist activity at alpha1D-adrenergic receptor (unknown origin)
ChEMBL 430 6 2 6 3.8 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F 10.1016/j.bmcl.2017.03.085
CHEMBL4061793 162773 18 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at alpha1D-adrenergic receptor (unknown origin)Antagonist activity at alpha1D-adrenergic receptor (unknown origin)
ChEMBL 430 6 2 6 3.8 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F 10.1016/j.bmcl.2017.03.085
85469870 143428 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 439 6 0 4 4.2 Cc1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
CHEMBL3740042 143428 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 439 6 0 4 4.2 Cc1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 10.1016/j.bmc.2015.11.020
135 9310 43 None -10 56 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
1796 9310 43 None -10 56 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
4184 9310 43 None -10 56 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
CHEMBL6437 9310 43 None -10 56 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
DB06148 9310 43 None -10 56 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
3168 16034 92 None -29 22 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 nan
CHEMBL1108 16034 92 None -29 22 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 nan
1353 8692 93 None -10 85 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
3559 8692 93 None -10 85 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
86 8692 93 None -10 85 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
CHEMBL54 8692 93 None -10 85 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
DB00502 8692 93 None -10 85 Human 7.1 pIC50 = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
85469809 143479 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 467 7 0 5 4.1 CC(=O)c1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
CHEMBL3740558 143479 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 467 7 0 5 4.1 CC(=O)c1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 10.1016/j.bmc.2015.11.020
44343247 117412 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 258 6 3 3 2.2 CCCNC(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
CHEMBL325745 117412 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 258 6 3 3 2.2 CCCNC(=O)c1ccccc1NCc1c[nH]cn1 10.1016/s0960-894x(02)00753-9
3198 212292 76 None -30 34 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 212292 76 None -30 34 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 212292 76 None -30 34 Human 5.1 pIC50 = 5.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
10198532 214475 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 232 4 3 4 0.5 CNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
CHEMBL95523 214475 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptorConcentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
ChEMBL 232 4 3 4 0.5 CNC(=O)c1ccccc1NCC1=NCCN1 10.1016/s0960-894x(01)00569-8
2389 10104 118 None -24 66 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
5073 10104 118 None -24 66 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
96 10104 118 None -24 66 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
CHEMBL85 10104 118 None -24 66 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
DB00734 10104 118 None -24 66 Human 8.0 pIC50 = 8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
135398745 9688 112 None -24 65 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
47 9688 112 None -24 65 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
CHEMBL715 9688 112 None -24 65 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
DB00334 9688 112 None -24 65 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
44343257 17272 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 250 4 1 2 3.7 c1ccc(-c2ccccc2OCc2c[nH]cn2)cc1 10.1016/s0960-894x(02)00753-9
CHEMBL116700 17272 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1D-adrenoceptor receptors expressed in rat-1 fibroblasts
ChEMBL 250 4 1 2 3.7 c1ccc(-c2ccccc2OCc2c[nH]cn2)cc1 10.1016/s0960-894x(02)00753-9
85469757 143517 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 468 6 0 5 3.9 N#Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)c(F)c1 10.1016/j.bmc.2015.11.020
CHEMBL3740874 143517 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
ChEMBL 468 6 0 5 3.9 N#Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)c(F)c1 10.1016/j.bmc.2015.11.020
2337 10030 77 None -2 62 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
50 10030 77 None -2 62 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
5002 10030 77 None -2 62 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
CHEMBL716 10030 77 None -2 62 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
DB01224 10030 77 None -2 62 Human 7.0 pIC50 = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
2351 10059 64 None -8 21 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 10059 64 None -8 21 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 10059 64 None -8 21 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 10059 64 None -8 21 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 10059 64 None -8 21 Human 6.0 pIC50 = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
491 6980 9 None 3 12 Rat 10.7 pKd = 10.7 Binding
In vitro functional activity at Alpha-1D receptor in rat aortaIn vitro functional activity at Alpha-1D receptor in rat aorta
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
9891167 6980 9 None 3 12 Rat 10.7 pKd = 10.7 Binding
In vitro functional activity at Alpha-1D receptor in rat aortaIn vitro functional activity at Alpha-1D receptor in rat aorta
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
CHEMBL13856 6980 9 None 3 12 Rat 10.7 pKd = 10.7 Binding
In vitro functional activity at Alpha-1D receptor in rat aortaIn vitro functional activity at Alpha-1D receptor in rat aorta
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
490 6979 8 None 2 12 Rat 10.6 pKd = 10.6 Binding
In vitro functional activity at Alpha-1D adrenergic receptor in rat aortaIn vitro functional activity at Alpha-1D adrenergic receptor in rat aorta
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
9890547 6979 8 None 2 12 Rat 10.6 pKd = 10.6 Binding
In vitro functional activity at Alpha-1D adrenergic receptor in rat aortaIn vitro functional activity at Alpha-1D adrenergic receptor in rat aorta
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
CHEMBL268758 6979 8 None 2 12 Rat 10.6 pKd = 10.6 Binding
In vitro functional activity at Alpha-1D adrenergic receptor in rat aortaIn vitro functional activity at Alpha-1D adrenergic receptor in rat aorta
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
71817547 109355 0 None 7 7 Rat 9.6 pKd = 9.6 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 357 7 1 6 2.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)OCC2 10.1021/jm400867d
CHEMBL2419771 109355 0 None 7 7 Rat 9.6 pKd = 9.6 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 357 7 1 6 2.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)OCC2 10.1021/jm400867d
CHEMBL3040800 109355 0 None 7 7 Rat 9.6 pKd = 9.6 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 357 7 1 6 2.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)OCC2 10.1021/jm400867d
71817386 109363 0 None -1 7 Rat 9.0 pKd = 9.0 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 355 7 1 6 3.3 COc1ccc2ccoc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL2419769 109363 0 None -1 7 Rat 9.0 pKd = 9.0 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 355 7 1 6 3.3 COc1ccc2ccoc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL3040851 109363 0 None -1 7 Rat 9.0 pKd = 9.0 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 355 7 1 6 3.3 COc1ccc2ccoc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
3584 10549 64 None -1 14 Rat 8.8 pKd = 8.8 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.ejmech.2015.04.005
5401 10549 64 None -1 14 Rat 8.8 pKd = 8.8 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.ejmech.2015.04.005
7302 10549 64 None -1 14 Rat 8.8 pKd = 8.8 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.ejmech.2015.04.005
CHEMBL611 10549 64 None -1 14 Rat 8.8 pKd = 8.8 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.ejmech.2015.04.005
DB01162 10549 64 None -1 14 Rat 8.8 pKd = 8.8 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/j.ejmech.2015.04.005
4418 40996 85 None -12 7 Rat 7.9 pKd = 7.9 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL142635 40996 85 None -12 7 Rat 7.9 pKd = 7.9 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
73438500 125306 0 None 2 3 Rat 7.9 pKd = 7.9 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 392 7 2 4 3.1 COc1ccccc1N1CCN(CCCNC(=O)c2ccc3[nH]ccc3c2)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415011 125306 0 None 2 3 Rat 7.9 pKd = 7.9 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 392 7 2 4 3.1 COc1ccccc1N1CCN(CCCNC(=O)c2ccc3[nH]ccc3c2)CC1 10.1016/j.ejmech.2015.04.005
10252540 92132 1 None -416 6 Rat 6.9 pKd = 6.9 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) spleenAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) spleen
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL2261604 92132 1 None -416 6 Rat 6.9 pKd = 6.9 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) spleenAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) spleen
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
155534921 178766 0 None -1 3 Rat 6.9 pKd = 6.9 Binding
Antagonistic activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 0.5 hrs in presence of alpha2/beta adrenoceptor blocker yohimbine, propranolol by Schild plot analysisAntagonistic activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 0.5 hrs in presence of alpha2/beta adrenoceptor blocker yohimbine, propranolol by Schild plot analysis
ChEMBL 461 8 2 6 3.9 COc1ccc(OC)c(N2CCN(CC(O)COc3cccc4[nH]c5ccccc5c34)CC2)c1 10.1016/j.bmc.2016.09.010
CHEMBL4471070 178766 0 None -1 3 Rat 6.9 pKd = 6.9 Binding
Antagonistic activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 0.5 hrs in presence of alpha2/beta adrenoceptor blocker yohimbine, propranolol by Schild plot analysisAntagonistic activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 0.5 hrs in presence of alpha2/beta adrenoceptor blocker yohimbine, propranolol by Schild plot analysis
ChEMBL 461 8 2 6 3.9 COc1ccc(OC)c(N2CCN(CC(O)COc3cccc4[nH]c5ccccc5c34)CC2)c1 10.1016/j.bmc.2016.09.010
4418 40996 85 None -12 7 Rat 6.8 pKd = 6.8 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmc.2019.05.004
CHEMBL142635 40996 85 None -12 7 Rat 6.8 pKd = 6.8 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmc.2019.05.004
73437678 125312 0 None 4 3 Rat 7.8 pKd = 7.8 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 470 7 2 4 3.9 COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccc(Br)cc3[nH]2)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415017 125312 0 None 4 3 Rat 7.8 pKd = 7.8 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 470 7 2 4 3.9 COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccc(Br)cc3[nH]2)CC1 10.1016/j.ejmech.2015.04.005
148102091 180712 0 None - 1 Rat 5.8 pKd = 5.8 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 444 7 1 8 1.6 COc1cc2c(cc1OCC(O)CN1CCN(C(=O)c3ccco3)CC1)C(=O)C(C)OC2 10.1016/j.bmc.2019.05.004
CHEMBL4540946 180712 0 None - 1 Rat 5.8 pKd = 5.8 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 444 7 1 8 1.6 COc1cc2c(cc1OCC(O)CN1CCN(C(=O)c3ccco3)CC1)C(=O)C(C)OC2 10.1016/j.bmc.2019.05.004
73437729 125313 0 None 2 3 Rat 7.7 pKd = 7.7 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 426 7 2 4 3.8 COc1ccccc1N1CCN(CCCNC(=O)c2cc3cc(Cl)ccc3[nH]2)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415018 125313 0 None 2 3 Rat 7.7 pKd = 7.7 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 426 7 2 4 3.8 COc1ccccc1N1CCN(CCCNC(=O)c2cc3cc(Cl)ccc3[nH]2)CC1 10.1016/j.ejmech.2015.04.005
155567902 182773 0 None -5 3 Rat 6.7 pKd = 6.7 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 448 7 1 8 0.9 COc1cc2c(cc1OCC(O)CN1CCN(C(=O)C3CCCO3)CC1)C(=O)C(C)OC2 10.1016/j.bmc.2019.05.004
CHEMBL4589115 182773 0 None -5 3 Rat 6.7 pKd = 6.7 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 448 7 1 8 0.9 COc1cc2c(cc1OCC(O)CN1CCN(C(=O)C3CCCO3)CC1)C(=O)C(C)OC2 10.1016/j.bmc.2019.05.004
71817549 109357 0 None -2 7 Rat 8.6 pKd = 8.6 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 356 7 2 6 2.5 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)NCC2 10.1021/jm400867d
CHEMBL3040803 109357 0 None -2 7 Rat 8.6 pKd = 8.6 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 356 7 2 6 2.5 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)NCC2 10.1021/jm400867d
CHEMBL3216590 109357 0 None -2 7 Rat 8.6 pKd = 8.6 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 356 7 2 6 2.5 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)NCC2 10.1021/jm400867d
118733023 125315 0 None 2 3 Rat 8.6 pKd = 8.6 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 482 9 1 5 4.6 COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccc3n2Cc2ccccc2)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415020 125315 0 None 2 3 Rat 8.6 pKd = 8.6 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 482 9 1 5 4.6 COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccc3n2Cc2ccccc2)CC1 10.1016/j.ejmech.2015.04.005
76326562 112983 0 None -154 4 Rat 6.7 pKd = 6.7 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL2261608 112983 0 None -154 4 Rat 6.7 pKd = 6.7 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL3138761 112983 0 None -154 4 Rat 6.7 pKd = 6.7 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
148774769 180666 0 None - 1 Rat 5.7 pKd = 5.7 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 456 8 1 8 2.4 COc1cc2c(cc1OCC(O)CN1CCN(c3ccccc3OC)CC1)COC(C)C2=O 10.1016/j.bmc.2019.05.004
CHEMBL4539815 180666 0 None - 1 Rat 5.7 pKd = 5.7 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 456 8 1 8 2.4 COc1cc2c(cc1OCC(O)CN1CCN(c3ccccc3OC)CC1)COC(C)C2=O 10.1016/j.bmc.2019.05.004
127040061 143704 0 None -6 5 Rat 7.6 pKd = 7.6 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 mins
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL3739932 143704 0 None -6 5 Rat 7.6 pKd = 7.6 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 mins
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL3742489 143704 0 None -6 5 Rat 7.6 pKd = 7.6 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 mins
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
73437675 125310 0 None 2 3 Rat 7.6 pKd = 7.6 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 408 7 3 5 2.8 COc1ccccc1N1CCN(CCCNC(=O)c2cc3cc(O)ccc3[nH]2)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415015 125310 0 None 2 3 Rat 7.6 pKd = 7.6 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 408 7 3 5 2.8 COc1ccccc1N1CCN(CCCNC(=O)c2cc3cc(O)ccc3[nH]2)CC1 10.1016/j.ejmech.2015.04.005
9950711 115983 0 None -154 4 Rat 4.6 pKd = 4.6 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
ChEMBL 359 4 2 3 3.2 O=S(=O)(CC(F)(F)F)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL321644 115983 0 None -154 4 Rat 4.6 pKd = 4.6 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
ChEMBL 359 4 2 3 3.2 O=S(=O)(CC(F)(F)F)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
73437730 125311 0 None 2 3 Rat 7.6 pKd = 7.6 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 437 8 2 6 3.0 COc1ccccc1N1CCN(CCCNC(=O)c2cc3cccc([N+](=O)[O-])c3[nH]2)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415016 125311 0 None 2 3 Rat 7.6 pKd = 7.6 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 437 8 2 6 3.0 COc1ccccc1N1CCN(CCCNC(=O)c2cc3cccc([N+](=O)[O-])c3[nH]2)CC1 10.1016/j.ejmech.2015.04.005
155563192 182101 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 426 7 1 7 2.4 COc1ccc2c(c1OCC(O)CN1CCN(c3ccccc3)CC1)COC(C)C2=O 10.1016/j.bmc.2019.05.004
CHEMBL4573703 182101 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 426 7 1 7 2.4 COc1ccc2c(c1OCC(O)CN1CCN(c3ccccc3)CC1)COC(C)C2=O 10.1016/j.bmc.2019.05.004
86288950 119420 0 None 2 6 Rat 8.5 pKd = 8.5 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
ChEMBL 452 8 0 4 3.9 CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
CHEMBL3233666 119420 0 None 2 6 Rat 8.5 pKd = 8.5 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
ChEMBL 452 8 0 4 3.9 CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
CHEMBL3302931 119420 0 None 2 6 Rat 8.5 pKd = 8.5 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
ChEMBL 452 8 0 4 3.9 CN1C(=O)N(CCCCCN2CCN(c3ccccc3F)CC2)C(C)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
71817545 98899 0 None 2 7 Rat 8.5 pKd = 8.5 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 354 7 2 5 3.0 COc1ccc2cc[nH]c2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL2419765 98899 0 None 2 7 Rat 8.5 pKd = 8.5 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 354 7 2 5 3.0 COc1ccc2cc[nH]c2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
155546966 180409 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 448 7 1 8 0.9 COc1ccc2c(c1OCC(O)CN1CCN(C(=O)C3CCCO3)CC1)COC(C)C2=O 10.1016/j.bmc.2019.05.004
CHEMBL4533900 180409 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 448 7 1 8 0.9 COc1ccc2c(c1OCC(O)CN1CCN(C(=O)C3CCCO3)CC1)COC(C)C2=O 10.1016/j.bmc.2019.05.004
73437673 125308 0 None 5 3 Rat 7.5 pKd = 7.5 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 420 9 2 4 3.4 COc1ccccc1N1CCN(CCCNC(=O)CCc2c[nH]c3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415013 125308 0 None 5 3 Rat 7.5 pKd = 7.5 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 420 9 2 4 3.4 COc1ccccc1N1CCN(CCCNC(=O)CCc2c[nH]c3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
2419 7482 28 None -3 11 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm400867d
9 7482 28 None -3 11 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm400867d
CHEMBL13647 7482 28 None -3 11 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysisAntagonist activity at alpha-1D adrenoreceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced tissue contraction after 30 mins by Schild plot analysis
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm400867d
155569671 182974 0 None - 1 Rat 6.3 pKd = 6.3 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 470 9 1 8 2.8 CCOc1ccccc1N1CCN(CC(O)COc2cc3c(cc2OC)COC(C)C3=O)CC1 10.1016/j.bmc.2019.05.004
CHEMBL4593702 182974 0 None - 1 Rat 6.3 pKd = 6.3 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 470 9 1 8 2.8 CCOc1ccccc1N1CCN(CC(O)COc2cc3c(cc2OC)COC(C)C3=O)CC1 10.1016/j.bmc.2019.05.004
73437674 125309 0 None 2 3 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 434 10 2 4 3.8 COc1ccccc1N1CCN(CCCNC(=O)CCCc2c[nH]c3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415014 125309 0 None 2 3 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 434 10 2 4 3.8 COc1ccccc1N1CCN(CCCNC(=O)CCCc2c[nH]c3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
127040157 143705 0 None -1 5 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 mins
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL3739897 143705 0 None -1 5 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 mins
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL3742490 143705 0 None -1 5 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 mins
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
73438501 125307 0 None 1 3 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 406 8 2 4 3.0 COc1ccccc1N1CCN(CCCNC(=O)Cc2c[nH]c3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415012 125307 0 None 1 3 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 406 8 2 4 3.0 COc1ccccc1N1CCN(CCCNC(=O)Cc2c[nH]c3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
73437677 125314 0 None 9 3 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 406 7 1 5 3.1 COc1ccccc1N1CCN(CCCNC(=O)c2cn(C)c3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
CHEMBL3415019 125314 0 None 9 3 Rat 8.3 pKd = 8.3 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 406 7 1 5 3.1 COc1ccccc1N1CCN(CCCNC(=O)c2cn(C)c3ccccc23)CC1 10.1016/j.ejmech.2015.04.005
10252540 92132 1 None -416 6 Rat 7.3 pKd = 7.3 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL2261604 92132 1 None -416 6 Rat 7.3 pKd = 7.3 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
73437676 125274 0 None 1 3 Rat 7.2 pKd = 7.2 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 422 8 2 5 3.1 COc1ccc2[nH]c(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)cc2c1 10.1016/j.ejmech.2015.04.005
CHEMBL3414578 125274 0 None 1 3 Rat 7.2 pKd = 7.2 Binding
Antagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 minsAntagonist activity at Sprague-Dawley rat thoracic aorta adrenergic alpha-1D receptor after 20 mins
ChEMBL 422 8 2 5 3.1 COc1ccc2[nH]c(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)cc2c1 10.1016/j.ejmech.2015.04.005
76330229 113012 0 None -190 4 Rat 7.2 pKd = 7.2 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL2261605 113012 0 None -190 4 Rat 7.2 pKd = 7.2 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL3138857 113012 0 None -190 4 Rat 7.2 pKd = 7.2 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
9903797 16211 5 None -18 4 Rat 5.2 pKd = 5.2 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
ChEMBL 279 5 2 3 2.1 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1C 10.1007/s00044-004-0020-z
CHEMBL111734 16211 5 None -18 4 Rat 5.2 pKd = 5.2 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
ChEMBL 279 5 2 3 2.1 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1C 10.1007/s00044-004-0020-z
2419 7482 28 None -3 11 Rat 8.2 pKd = 8.2 Binding
In vitro functional activity at Alpha-1D adrenergic receptor in rat aortaIn vitro functional activity at Alpha-1D adrenergic receptor in rat aorta
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(01)00159-7
9 7482 28 None -3 11 Rat 8.2 pKd = 8.2 Binding
In vitro functional activity at Alpha-1D adrenergic receptor in rat aortaIn vitro functional activity at Alpha-1D adrenergic receptor in rat aorta
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(01)00159-7
CHEMBL13647 7482 28 None -3 11 Rat 8.2 pKd = 8.2 Binding
In vitro functional activity at Alpha-1D adrenergic receptor in rat aortaIn vitro functional activity at Alpha-1D adrenergic receptor in rat aorta
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(01)00159-7
9976756 13379 0 None -1 5 Rat 8.2 pKd = 8.2 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 mins
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL1083181 13379 0 None -1 5 Rat 8.2 pKd = 8.2 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 mins
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL37883 13379 0 None -1 5 Rat 8.2 pKd = 8.2 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline-induced contractions after 30 mins
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
147858071 177718 0 None - 1 Rat 6.2 pKd = 6.2 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 426 7 1 7 2.4 COc1cc2c(cc1OCC(O)CN1CCN(c3ccccc3)CC1)COC(C)C2=O 10.1016/j.bmc.2019.05.004
CHEMBL4455376 177718 0 None - 1 Rat 6.2 pKd = 6.2 Binding
Antagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractionsAntagonist activity at alpha-1D adrenergic receptor in SPF rat vas thoracic aorta assessed as inhibition of noradrenaline-induced contractions
ChEMBL 426 7 1 7 2.4 COc1cc2c(cc1OCC(O)CN1CCN(c3ccccc3)CC1)COC(C)C2=O 10.1016/j.bmc.2019.05.004
9838192 118089 18 None -2 6 Rat 6.2 pKd = 6.2 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1007/s00044-004-0020-z
CHEMBL326702 118089 18 None -2 6 Rat 6.2 pKd = 6.2 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1007/s00044-004-0020-z
86288949 119402 0 None 5 5 Rat 8.1 pKd = 8.1 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
ChEMBL 434 8 0 4 3.8 CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(C)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
CHEMBL3233665 119402 0 None 5 5 Rat 8.1 pKd = 8.1 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
ChEMBL 434 8 0 4 3.8 CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(C)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
CHEMBL3302599 119402 0 None 5 5 Rat 8.1 pKd = 8.1 Binding
Antagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 minsAntagonist activity at alpha1D adrenoceptor in Wistar (Krf:(WI) WU) rat endothelium-denuded thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 30 mins
ChEMBL 434 8 0 4 3.8 CN1C(=O)N(CCCCCN2CCN(c3ccccc3)CC2)C(C)(c2ccccc2)C1=O 10.1016/j.ejmech.2014.01.065
76326541 92116 0 None -60 4 Rat 5.1 pKd = 5.1 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCC[C@H]2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL2261355 92116 0 None -60 4 Rat 5.1 pKd = 5.1 Binding
Antagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contractionAntagonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aorta assessed as inhibition of phenylephrine-indued contraction
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCC[C@H]2c1c[nH]cn1 10.1007/s00044-004-0020-z
155559152 181559 0 None 21 3 Rat 7.1 pKd = 7.1 Binding
Antagonistic activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 0.5 hrs in presence of alpha2/beta adrenoceptor blocker yohimbine, propranolol by Schild plot analysisAntagonistic activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 0.5 hrs in presence of alpha2/beta adrenoceptor blocker yohimbine, propranolol by Schild plot analysis
ChEMBL 431 7 2 5 3.9 COc1ccc(N2CCN(CC(O)COc3cccc4[nH]c5ccccc5c34)CC2)cc1 10.1016/j.bmc.2016.09.010
CHEMBL4561614 181559 0 None 21 3 Rat 7.1 pKd = 7.1 Binding
Antagonistic activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 0.5 hrs in presence of alpha2/beta adrenoceptor blocker yohimbine, propranolol by Schild plot analysisAntagonistic activity at alpha1D adrenoceptor in Sprague-Dawley rat thoracic aorta assessed as inhibition of noradrenaline-induced contractions after 0.5 hrs in presence of alpha2/beta adrenoceptor blocker yohimbine, propranolol by Schild plot analysis
ChEMBL 431 7 2 5 3.9 COc1ccc(N2CCN(CC(O)COc3cccc4[nH]c5ccccc5c34)CC2)cc1 10.1016/j.bmc.2016.09.010
76308474 113011 0 None -102 5 Rat 7.1 pKd = 7.1 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@H]3CCCC[C@@H]32)o1 10.1007/s00044-004-0024-8
CHEMBL2261607 113011 0 None -102 5 Rat 7.1 pKd = 7.1 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@H]3CCCC[C@@H]32)o1 10.1007/s00044-004-0024-8
CHEMBL3138856 113011 0 None -102 5 Rat 7.1 pKd = 7.1 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@H]3CCCC[C@@H]32)o1 10.1007/s00044-004-0024-8
76323010 113025 0 None -104 4 Rat 7.0 pKd = 7.0 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL2261606 113025 0 None -104 4 Rat 7.0 pKd = 7.0 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL3138929 113025 0 None -104 4 Rat 7.0 pKd = 7.0 Binding
Competitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contractionCompetitive antagonist activity at alpha1D adrenergic receptor in Rattus norvegicus (rat) aorta assessed as inhibition of (-)-noradrenaline-induced contraction
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
521 8186 69 None 2 7 Human 10.8 pKi = 10.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 10.1021/jm0003891
5311068 8186 69 None 2 7 Human 10.8 pKi = 10.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 10.1021/jm0003891
835 8186 69 None 2 7 Human 10.8 pKi = 10.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 10.1021/jm0003891
CHEMBL778 8186 69 None 2 7 Human 10.8 pKi = 10.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 10.1021/jm0003891
DB00633 8186 69 None 2 7 Human 10.8 pKi = 10.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C 10.1021/jm0003891
164089 117130 24 None 1 5 Rat 10.5 pKi = 10.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 395 5 1 7 3.4 COc1cc2c(cc1OC)CN(c1cc(N)c3cc(OC)c(OC)cc3n1)CC2 10.1021/jm00018a001
CHEMBL324090 117130 24 None 1 5 Rat 10.5 pKi = 10.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 395 5 1 7 3.4 COc1cc2c(cc1OC)CN(c1cc(N)c3cc(OC)c(OC)cc3n1)CC2 10.1021/jm00018a001
11583392 79689 1 None 7 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 457 13 1 6 5.0 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc(Cl)cc1 10.1021/jm0580398
CHEMBL200446 79689 1 None 7 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 457 13 1 6 5.0 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc(Cl)cc1 10.1021/jm0580398
9891213 168281 0 None 4 6 Human 10.4 pKi = 10.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 477 5 1 8 4.0 COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4128084 168281 0 None 4 6 Human 10.4 pKi = 10.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 477 5 1 8 4.0 COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
164089 117130 24 None -1 5 Human 10.4 pKi = 10.4 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 395 5 1 7 3.4 COc1cc2c(cc1OC)CN(c1cc(N)c3cc(OC)c(OC)cc3n1)CC2 10.1021/jm00018a001
CHEMBL324090 117130 24 None -1 5 Human 10.4 pKi = 10.4 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 395 5 1 7 3.4 COc1cc2c(cc1OC)CN(c1cc(N)c3cc(OC)c(OC)cc3n1)CC2 10.1021/jm00018a001
11554541 78583 0 None 7 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 468 14 1 8 4.2 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc([N+](=O)[O-])cc1 10.1021/jm0580398
CHEMBL196817 78583 0 None 7 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 468 14 1 8 4.2 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc([N+](=O)[O-])cc1 10.1021/jm0580398
11626704 79229 0 None 3 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 457 13 1 6 5.0 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc(Cl)c1 10.1021/jm0580398
CHEMBL198860 79229 0 None 3 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 457 13 1 6 5.0 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc(Cl)c1 10.1021/jm0580398
13155 10195 0 None 16 3 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 668 12 2 9 4.5 CN(C(CCCC(=O)NC=1C=CC2=C(C1)C=3NC(N(C(C3S2)=O)CCN4CCN(CC4)C5=C(C=CC=C5)OC)=O)=O)CC6=CC=CC=C6 10.1016/j.ejmech.2014.06.057
90645598 10195 0 None 16 3 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 668 12 2 9 4.5 CN(C(CCCC(=O)NC=1C=CC2=C(C1)C=3NC(N(C(C3S2)=O)CCN4CCN(CC4)C5=C(C=CC=C5)OC)=O)=O)CC6=CC=CC=C6 10.1016/j.ejmech.2014.06.057
CHEMBL3297829 10195 0 None 16 3 Human 10.3 pKi = 10.3 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 668 12 2 9 4.5 CN(C(CCCC(=O)NC=1C=CC2=C(C1)C=3NC(N(C(C3S2)=O)CCN4CCN(CC4)C5=C(C=CC=C5)OC)=O)=O)CC6=CC=CC=C6 10.1016/j.ejmech.2014.06.057
129211 10521 78 None -1 16 Human 10.2 pKi = 10.2 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
2562 10521 78 None -1 16 Human 10.2 pKi = 10.2 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
488 10521 78 None -1 16 Human 10.2 pKi = 10.2 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
CHEMBL836 10521 78 None -1 16 Human 10.2 pKi = 10.2 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
DB00706 10521 78 None -1 16 Human 10.2 pKi = 10.2 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm970364a
9824384 125565 1 None -2 8 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL342062 125565 1 None -2 8 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
11712470 78780 0 None 5 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 468 14 1 8 4.2 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc([N+](=O)[O-])c1 10.1021/jm0580398
CHEMBL197442 78780 0 None 5 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 468 14 1 8 4.2 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc([N+](=O)[O-])c1 10.1021/jm0580398
11604548 79663 0 None 3 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 437 13 1 6 4.6 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc(C)cc1 10.1021/jm0580398
CHEMBL200366 79663 0 None 3 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 437 13 1 6 4.6 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc(C)cc1 10.1021/jm0580398
145962342 168202 0 None 2 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 521 9 0 8 5.1 CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@@H]3CCCC[C@@H]32)nc2cc(OC)c(OC)cc12 10.1016/j.bmc.2018.05.023
CHEMBL4126860 168202 0 None 2 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 521 9 0 8 5.1 CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@@H]3CCCC[C@@H]32)nc2cc(OC)c(OC)cc12 10.1016/j.bmc.2018.05.023
10364994 174664 0 None 6 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 423 13 1 6 4.3 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1021/jm0580398
CHEMBL43116 174664 0 None 6 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 423 13 1 6 4.3 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1021/jm0580398
10364994 174664 0 None 6 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 423 13 1 6 4.3 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL43116 174664 0 None 6 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 423 13 1 6 4.3 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
9883062 66116 0 None - 1 Human 10.2 pKi = 10.2 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 3 1 2 2.6 CCc1sccc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL170694 66116 0 None - 1 Human 10.2 pKi = 10.2 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 3 1 2 2.6 CCc1sccc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL1744288 66116 0 None - 1 Human 10.2 pKi = 10.2 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 3 1 2 2.6 CCc1sccc1Cc1c[nH]cn1 10.1021/jm0003891
10782052 127527 1 None - 1 Human 10.2 pKi = 10.2 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 320 2 1 2 3.6 Brc1csc(Cc2c[nH]cn2)c1Br 10.1021/jm0003891
CHEMBL1203855 127527 1 None - 1 Human 10.2 pKi = 10.2 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 320 2 1 2 3.6 Brc1csc(Cc2c[nH]cn2)c1Br 10.1021/jm0003891
CHEMBL355045 127527 1 None - 1 Human 10.2 pKi = 10.2 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 320 2 1 2 3.6 Brc1csc(Cc2c[nH]cn2)c1Br 10.1021/jm0003891
129211 10521 78 None -1 16 Rat 10.2 pKi = 10.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm990567u
2562 10521 78 None -1 16 Rat 10.2 pKi = 10.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm990567u
488 10521 78 None -1 16 Rat 10.2 pKi = 10.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm990567u
CHEMBL836 10521 78 None -1 16 Rat 10.2 pKi = 10.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm990567u
DB00706 10521 78 None -1 16 Rat 10.2 pKi = 10.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm990567u
12765746 109057 4 None 2 9 Rat 10.1 pKi = 10.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 344 1 0 3 4.3 CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm100652h
CHEMBL303313 109057 4 None 2 9 Rat 10.1 pKi = 10.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 344 1 0 3 4.3 CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm100652h
9992606 172490 0 None - 1 Human 10.1 pKi = 10.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 256 2 1 2 3.4 CC(c1c[nH]cn1)c1cscc1Br 10.1021/jm0003891
CHEMBL1788145 172490 0 None - 1 Human 10.1 pKi = 10.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 256 2 1 2 3.4 CC(c1c[nH]cn1)c1cscc1Br 10.1021/jm0003891
CHEMBL424573 172490 0 None - 1 Human 10.1 pKi = 10.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 256 2 1 2 3.4 CC(c1c[nH]cn1)c1cscc1Br 10.1021/jm0003891
34580 24663 2 None 1 4 Rat 10.1 pKi = 10.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 335 1 0 4 3.6 CN1CCN(C2Cc3ccccc3Sc3ccc(C#N)cc32)CC1 10.1021/jm100652h
CHEMBL1259112 24663 2 None 1 4 Rat 10.1 pKi = 10.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 335 1 0 4 3.6 CN1CCN(C2Cc3ccccc3Sc3ccc(C#N)cc32)CC1 10.1021/jm100652h
10775970 127221 0 None - 1 Human 10.1 pKi = 10.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 232 2 1 2 3.4 Clc1cc(Cc2c[nH]cn2)c(Cl)s1 10.1021/jm0003891
CHEMBL1744273 127221 0 None - 1 Human 10.1 pKi = 10.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 232 2 1 2 3.4 Clc1cc(Cc2c[nH]cn2)c(Cl)s1 10.1021/jm0003891
CHEMBL353904 127221 0 None - 1 Human 10.1 pKi = 10.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 232 2 1 2 3.4 Clc1cc(Cc2c[nH]cn2)c(Cl)s1 10.1021/jm0003891
11742834 172549 0 None -2 7 Human 10.1 pKi = 10.1 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 419 9 1 5 4.7 COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1 10.1021/jm011066n
CHEMBL42472 172549 0 None -2 7 Human 10.1 pKi = 10.1 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 419 9 1 5 4.7 COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1 10.1021/jm011066n
11984570 99579 0 None -2 3 Human 10.1 pKi = 10.1 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 465 5 0 5 4.3 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccc(F)c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
CHEMBL243694 99579 0 None -2 3 Human 10.1 pKi = 10.1 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 465 5 0 5 4.3 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccc(F)c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
9813184 127548 0 None - 1 Human 10.1 pKi = 10.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 214 2 1 2 3.2 c1ccc2c(Cc3c[nH]cn3)csc2c1 10.1021/jm0003891
CHEMBL1744270 127548 0 None - 1 Human 10.1 pKi = 10.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 214 2 1 2 3.2 c1ccc2c(Cc3c[nH]cn3)csc2c1 10.1021/jm0003891
CHEMBL355340 127548 0 None - 1 Human 10.1 pKi = 10.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 214 2 1 2 3.2 c1ccc2c(Cc3c[nH]cn3)csc2c1 10.1021/jm0003891
11669646 79723 0 None 3 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 453 14 1 7 4.3 COc1ccc(COc2ccccc2OCCNCCOc2c(OC)cccc2OC)cc1 10.1021/jm0580398
CHEMBL200580 79723 0 None 3 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 453 14 1 7 4.3 COc1ccc(COc2ccccc2OCCNCCOc2c(OC)cccc2OC)cc1 10.1021/jm0580398
129211 10521 78 None -1 16 Human 10.0 pKi = 10 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2010.09.042
2562 10521 78 None -1 16 Human 10.0 pKi = 10 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2010.09.042
488 10521 78 None -1 16 Human 10.0 pKi = 10 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2010.09.042
CHEMBL836 10521 78 None -1 16 Human 10.0 pKi = 10 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2010.09.042
DB00706 10521 78 None -1 16 Human 10.0 pKi = 10 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.ejmech.2010.09.042
10845433 66143 1 None - 1 Human 10.0 pKi = 10 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.7 Cc1csc(C)c1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL170806 66143 1 None - 1 Human 10.0 pKi = 10 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.7 Cc1csc(C)c1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL1744272 66143 1 None - 1 Human 10.0 pKi = 10 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.7 Cc1csc(C)c1Cc1c[nH]cn1 10.1021/jm0003891
9822814 108726 0 None 72 5 Rat 10.0 pKi = 10.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 409 4 0 3 4.3 O=C1CC2(CCCC2)CCN1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL301224 108726 0 None 72 5 Rat 10.0 pKi = 10.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 409 4 0 3 4.3 O=C1CC2(CCCC2)CCN1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
11539392 148020 0 None 6 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 437 13 1 6 4.6 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1C 10.1021/jm0580398
CHEMBL382972 148020 0 None 6 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 437 13 1 6 4.6 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1C 10.1021/jm0580398
9954092 203425 0 None 1 6 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL56438 203425 0 None 1 6 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
9954092 203425 0 None -1 6 Rat 9.9 pKi = 9.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL56438 203425 0 None -1 6 Rat 9.9 pKi = 9.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
10434440 212273 0 None 4 4 Human 9.9 pKi = 9.9 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 461 8 1 8 2.9 COc1ccccc1N1CCN(CCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL80641 212273 0 None 4 4 Human 9.9 pKi = 9.9 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 461 8 1 8 2.9 COc1ccccc1N1CCN(CCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
44431620 93842 0 None 102 4 Human 9.9 pKi = 9.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 570 7 1 6 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cnc(Cl)c(Br)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL232609 93842 0 None 102 4 Human 9.9 pKi = 9.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 570 7 1 6 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cnc(Cl)c(Br)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
9908478 202415 1 None 6 7 Rat 9.9 pKi = 9.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 391 4 0 4 2.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)ccc2F)CC1 10.1021/jm030944+
CHEMBL556313 202415 1 None 6 7 Rat 9.9 pKi = 9.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 391 4 0 4 2.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)ccc2F)CC1 10.1021/jm030944+
49781892 24673 0 None -1 4 Rat 9.9 pKi = 9.9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 381 3 1 4 3.3 CC(=O)NCc1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
CHEMBL1259144 24673 0 None -1 4 Rat 9.9 pKi = 9.9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 381 3 1 4 3.3 CC(=O)NCc1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
90645597 119266 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 654 12 3 9 4.2 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)NCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298750 119266 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 654 12 3 9 4.2 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)NCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
12765746 109057 4 None 2 9 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 344 1 0 3 4.3 CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm020938y
CHEMBL303313 109057 4 None 2 9 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 344 1 0 3 4.3 CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm020938y
52942381 24664 0 None -3 4 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 339 2 1 4 3.1 CN1CCN(C2Cc3ccccc3Sc3ccc(CN)cc32)CC1 10.1021/jm100652h
CHEMBL1259113 24664 0 None -3 4 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 339 2 1 4 3.1 CN1CCN(C2Cc3ccccc3Sc3ccc(CN)cc32)CC1 10.1021/jm100652h
10430193 168377 0 None 4 6 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 385 3 1 7 2.2 COc1cc2nc(N3CCN(C(C)=O)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4129461 168377 0 None 4 6 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 385 3 1 7 2.2 COc1cc2nc(N3CCN(C(C)=O)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
129211 10521 78 None -1 16 Human 9.8 pKi = 9.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
2562 10521 78 None -1 16 Human 9.8 pKi = 9.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
488 10521 78 None -1 16 Human 9.8 pKi = 9.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
CHEMBL836 10521 78 None -1 16 Human 9.8 pKi = 9.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
DB00706 10521 78 None -1 16 Human 9.8 pKi = 9.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
16721110 90464 0 None 7 3 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 451 5 1 6 3.7 COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL220515 90464 0 None 7 3 Human 9.8 pKi = 9.8 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 451 5 1 6 3.7 COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
132266 8061 12 None -5 9 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm8016046
486 8061 12 None -5 9 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm8016046
CHEMBL423294 8061 12 None -5 9 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm8016046
45268939 203439 0 None -1 5 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1021/jm8016046
CHEMBL564481 203439 0 None -1 5 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1021/jm8016046
491 6980 9 None 3 12 Rat 9.8 pKi = 9.8 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
9891167 6980 9 None 3 12 Rat 9.8 pKi = 9.8 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
CHEMBL13856 6980 9 None 3 12 Rat 9.8 pKi = 9.8 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
4209 9937 75 None 1 33 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/acs.jmedchem.9b01465
4893 9937 75 None 1 33 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/acs.jmedchem.9b01465
503 9937 75 None 1 33 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/acs.jmedchem.9b01465
5385 9937 75 None 1 33 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/acs.jmedchem.9b01465
CHEMBL2 9937 75 None 1 33 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/acs.jmedchem.9b01465
DB00457 9937 75 None 1 33 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/acs.jmedchem.9b01465
49781893 24674 0 None -1 4 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 409 4 1 4 4.0 CC(C)C(=O)NCc1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
CHEMBL1259145 24674 0 None -1 4 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 409 4 1 4 4.0 CC(C)C(=O)NCc1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
10655390 127216 1 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.7 Cc1csc(Cc2c[nH]cn2)c1C 10.1021/jm0003891
CHEMBL1203846 127216 1 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.7 Cc1csc(Cc2c[nH]cn2)c1C 10.1021/jm0003891
CHEMBL353870 127216 1 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.7 Cc1csc(Cc2c[nH]cn2)c1C 10.1021/jm0003891
52947579 23822 0 None 2 4 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 439 13 1 6 5.0 COc1cccc(OC)c1SCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1254582 23822 0 None 2 4 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 439 13 1 6 5.0 COc1cccc(OC)c1SCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
9844321 107638 0 None 54 5 Rat 9.7 pKi = 9.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 407 4 0 4 3.3 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL293539 107638 0 None 54 5 Rat 9.7 pKi = 9.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 407 4 0 4 3.3 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)ccc2Cl)CC1 10.1021/jm030944+
129211 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
2562 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
488 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
CHEMBL836 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
DB00706 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm9905918
129211 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.5b01528
2562 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.5b01528
488 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.5b01528
CHEMBL836 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.5b01528
DB00706 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of [125I] HEAT from human alpha1D adrenergic receptor expressed in Chlorocebus aethiops COS1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/acs.jmedchem.5b01528
10706270 127600 1 None - 1 Human 9.7 pKi = 9.7 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 256 2 1 2 3.4 CC(c1c[nH]cn1)c1sccc1Br 10.1021/jm0003891
CHEMBL1237159 127600 1 None - 1 Human 9.7 pKi = 9.7 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 256 2 1 2 3.4 CC(c1c[nH]cn1)c1sccc1Br 10.1021/jm0003891
CHEMBL355784 127600 1 None - 1 Human 9.7 pKi = 9.7 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 256 2 1 2 3.4 CC(c1c[nH]cn1)c1sccc1Br 10.1021/jm0003891
44289437 176642 0 None 1 7 Human 9.7 pKi = 9.7 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 431 9 1 5 4.7 COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O 10.1021/jm011066n
CHEMBL44403 176642 0 None 1 7 Human 9.7 pKi = 9.7 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 431 9 1 5 4.7 COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O 10.1021/jm011066n
14423371 104230 1 None -1 7 Human 9.7 pKi = 9.7 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 441 11 1 8 3.6 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL27013 104230 1 None -1 7 Human 9.7 pKi = 9.7 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 441 11 1 8 3.6 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1021/jm9810654
11633517 79300 0 None 1 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 437 13 1 6 4.6 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc(C)c1 10.1021/jm0580398
CHEMBL199080 79300 0 None 1 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 437 13 1 6 4.6 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc(C)c1 10.1021/jm0580398
129211 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.008
2562 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.008
488 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.008
CHEMBL836 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.008
DB00706 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.008
129211 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.098
2562 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.098
488 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.098
CHEMBL836 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.098
DB00706 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.04.098
9823115 205382 0 None 85 5 Rat 9.7 pKi = 9.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 414 4 0 5 3.0 N#Cc1ccc(Cl)cc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL57868 205382 0 None 85 5 Rat 9.7 pKi = 9.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 414 4 0 5 3.0 N#Cc1ccc(Cl)cc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
4209 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
4893 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
503 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
5385 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
CHEMBL2 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
DB00457 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
129211 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.11.068
2562 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.11.068
488 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.11.068
CHEMBL836 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.11.068
DB00706 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1016/j.bmcl.2007.11.068
44431180 99624 0 None 9 3 Human 9.7 pKi = 9.7 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 497 5 0 5 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccccc5c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
CHEMBL243864 99624 0 None 9 3 Human 9.7 pKi = 9.7 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 497 5 0 5 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccccc5c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
4209 9937 75 None -2 33 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm020938y
4893 9937 75 None -2 33 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm020938y
503 9937 75 None -2 33 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm020938y
5385 9937 75 None -2 33 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm020938y
CHEMBL2 9937 75 None -2 33 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm020938y
DB00457 9937 75 None -2 33 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm020938y
10812130 205960 0 None -2 3 Rat 9.7 pKi = 9.7 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 421 5 1 6 2.4 COc1ccc2c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)[nH]c2c1 10.1021/jm000541z
CHEMBL58956 205960 0 None -2 3 Rat 9.7 pKi = 9.7 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 421 5 1 6 2.4 COc1ccc2c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)[nH]c2c1 10.1021/jm000541z
49782998 24689 0 None -1 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 409 4 1 4 4.0 CC(C)C(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
CHEMBL1259190 24689 0 None -1 6 Rat 9.7 pKi = 9.7 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 409 4 1 4 4.0 CC(C)C(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
490 6979 8 None 2 12 Rat 9.7 pKi = 9.7 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
9890547 6979 8 None 2 12 Rat 9.7 pKi = 9.7 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
CHEMBL268758 6979 8 None 2 12 Rat 9.7 pKi = 9.7 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
4209 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
4893 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
503 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
5385 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
CHEMBL2 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
DB00457 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm9810654
4209 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm030952q
4893 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm030952q
503 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm030952q
5385 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm030952q
CHEMBL2 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm030952q
DB00457 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm030952q
4209 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2017.05.003
4893 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2017.05.003
503 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2017.05.003
5385 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2017.05.003
CHEMBL2 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2017.05.003
DB00457 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.ejmech.2017.05.003
4209 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
4893 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
503 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
5385 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
CHEMBL2 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
DB00457 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm049153d
13911290 34944 0 None -1 6 Rat 9.6 pKi = 9.6 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 386 5 1 7 1.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sccc3c2=O)CC1 10.1016/s0960-894x(01)00159-7
CHEMBL13735 34944 0 None -1 6 Rat 9.6 pKi = 9.6 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 386 5 1 7 1.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sccc3c2=O)CC1 10.1016/s0960-894x(01)00159-7
4209 9937 75 None 1 33 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm0009336
4893 9937 75 None 1 33 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm0009336
503 9937 75 None 1 33 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm0009336
5385 9937 75 None 1 33 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm0009336
CHEMBL2 9937 75 None 1 33 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm0009336
DB00457 9937 75 None 1 33 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm0009336
6603950 210103 9 None 1 8 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 344 1 0 3 4.3 CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm100652h
CHEMBL64875 210103 9 None 1 8 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 344 1 0 3 4.3 CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm100652h
11776530 127599 0 None - 1 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 242 2 1 2 2.8 Brc1cscc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL1744289 127599 0 None - 1 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 242 2 1 2 2.8 Brc1cscc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL355783 127599 0 None - 1 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 242 2 1 2 2.8 Brc1cscc1Cc1c[nH]cn1 10.1021/jm0003891
10622402 209539 0 None -6 3 Rat 9.6 pKi = 9.6 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 427 5 1 7 2.4 COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2s1 10.1021/jm000541z
CHEMBL62028 209539 0 None -6 3 Rat 9.6 pKi = 9.6 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 427 5 1 7 2.4 COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2s1 10.1021/jm000541z
49781452 24638 0 None -1 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 388 2 0 5 4.1 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4cncnc4)cc32)CC1 10.1021/jm100652h
CHEMBL1259042 24638 0 None -1 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 388 2 0 5 4.1 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4cncnc4)cc32)CC1 10.1021/jm100652h
10097792 125367 0 None -1 8 Human 9.6 pKi = 9.6 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 508 13 1 8 4.1 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN(C)C)c3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL341665 125367 0 None -1 8 Human 9.6 pKi = 9.6 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 508 13 1 8 4.1 COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN(C)C)c3)nc(N)c2cc1OC 10.1021/jm9810654
50905381 63124 0 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 422 11 2 6 2.7 COc1ccc(C[C@@H](C)NCCOc2ccccc2OC(C)C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
CHEMBL1630938 63124 0 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 422 11 2 6 2.7 COc1ccc(C[C@@H](C)NCCOc2ccccc2OC(C)C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
11134424 111508 0 None 1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 465 7 1 7 3.5 CC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2Cl)CC1 10.1021/jm0009336
CHEMBL310599 111508 0 None 1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 465 7 1 7 3.5 CC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2Cl)CC1 10.1021/jm0009336
10005161 212028 0 None -1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 475 9 1 8 3.3 CCC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2OC)CC1 10.1021/jm0009336
CHEMBL78874 212028 0 None -1 4 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 475 9 1 8 3.3 CCC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2OC)CC1 10.1021/jm0009336
9847845 35226 0 None 1 6 Rat 9.6 pKi = 9.6 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sc(C)c(-c4ccccc4)c3c2=O)CC1 10.1016/s0960-894x(01)00159-7
CHEMBL13754 35226 0 None 1 6 Rat 9.6 pKi = 9.6 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sc(C)c(-c4ccccc4)c3c2=O)CC1 10.1016/s0960-894x(01)00159-7
499 10849 18 None -1 14 Human 9.6 pKi = 9.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm960697s
5685 10849 18 None -1 14 Human 9.6 pKi = 9.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm960697s
CHEMBL25554 10849 18 None -1 14 Human 9.6 pKi = 9.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm960697s
11712250 79775 0 None 2 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 457 13 1 6 5.0 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1Cl 10.1021/jm0580398
CHEMBL200839 79775 0 None 2 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 457 13 1 6 5.0 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1Cl 10.1021/jm0580398
490 6979 8 None -2 12 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
9890547 6979 8 None -2 12 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
CHEMBL268758 6979 8 None -2 12 Human 9.6 pKi = 9.6 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 10.1016/s0960-894x(01)00159-7
10673690 107278 0 None 1 3 Rat 9.6 pKi = 9.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 490 5 2 7 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cc(C(N)=O)ccc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL291073 107278 0 None 1 3 Rat 9.6 pKi = 9.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 490 5 2 7 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cc(C(N)=O)ccc54)c3=O)C[C@@H]21 10.1021/jm990567u
10536288 127031 2 None - 1 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 3 1 2 3.2 CCc1cscc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL1744263 127031 2 None - 1 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 3 1 2 3.2 CCc1cscc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL352348 127031 2 None - 1 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 3 1 2 3.2 CCc1cscc1C(C)c1c[nH]cn1 10.1021/jm0003891
9955302 106943 0 None 1 3 Rat 9.6 pKi = 9.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccncc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL287965 106943 0 None 1 3 Rat 9.6 pKi = 9.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccncc54)c3=O)C[C@@H]21 10.1021/jm990567u
10511960 127540 1 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 3 1 2 2.6 CCc1cscc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL1744278 127540 1 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 3 1 2 2.6 CCc1cscc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL355231 127540 1 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 3 1 2 2.6 CCc1cscc1Cc1c[nH]cn1 10.1021/jm0003891
4209 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm981006q
4893 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm981006q
503 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm981006q
5385 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm981006q
CHEMBL2 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm981006q
DB00457 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm981006q
4209 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
4893 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
503 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
5385 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
CHEMBL2 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
DB00457 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00010a001
4209 9937 75 None -2 33 Rat 9.5 pKi = 9.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
4893 9937 75 None -2 33 Rat 9.5 pKi = 9.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
503 9937 75 None -2 33 Rat 9.5 pKi = 9.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
5385 9937 75 None -2 33 Rat 9.5 pKi = 9.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
CHEMBL2 9937 75 None -2 33 Rat 9.5 pKi = 9.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
DB00457 9937 75 None -2 33 Rat 9.5 pKi = 9.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm980053f
13156 10220 0 None 416 3 Human 9.5 pKi = 9.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 382 6 2 5 2.9 FC1=C(OCCN[C@H]2CCS(C3=CC=C(C=C23)NC)(=O)=O)C=C(C=C1)F 10.1016/j.ejmech.2017.07.071
145946376 10220 0 None 416 3 Human 9.5 pKi = 9.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 382 6 2 5 2.9 FC1=C(OCCN[C@H]2CCS(C3=CC=C(C=C23)NC)(=O)=O)C=C(C=C1)F 10.1016/j.ejmech.2017.07.071
CHEMBL4299993 10220 0 None 416 3 Human 9.5 pKi = 9.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 382 6 2 5 2.9 FC1=C(OCCN[C@H]2CCS(C3=CC=C(C=C23)NC)(=O)=O)C=C(C=C1)F 10.1016/j.ejmech.2017.07.071
4431 9506 25 None -1 12 Human 9.5 pKi = 9.5 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.bmcl.2006.12.111
73 9506 25 None -1 12 Human 9.5 pKi = 9.5 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.bmcl.2006.12.111
CHEMBL8618 9506 25 None -1 12 Human 9.5 pKi = 9.5 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 10.1016/j.bmcl.2006.12.111
44431174 99578 0 None 8 3 Human 9.5 pKi = 9.5 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 515 5 0 5 5.5 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cc(Cl)c(Cl)cc4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
CHEMBL243692 99578 0 None 8 3 Human 9.5 pKi = 9.5 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 515 5 0 5 5.5 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cc(Cl)c(Cl)cc4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
4209 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm990201h
4893 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm990201h
503 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm990201h
5385 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm990201h
CHEMBL2 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm990201h
DB00457 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm990201h
13911290 34944 0 None -1 6 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 386 5 1 7 1.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sccc3c2=O)CC1 10.1016/s0960-894x(01)00159-7
CHEMBL13735 34944 0 None -1 6 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 386 5 1 7 1.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sccc3c2=O)CC1 10.1016/s0960-894x(01)00159-7
10553935 168599 0 None 1 3 Rat 9.5 pKi = 9.5 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 481 4 1 6 4.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(Cl)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL41444 168599 0 None 1 3 Rat 9.5 pKi = 9.5 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 481 4 1 6 4.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(Cl)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
491 6980 9 None -3 12 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
9891167 6980 9 None -3 12 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
CHEMBL13856 6980 9 None -3 12 Human 9.5 pKi = 9.5 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 10.1016/s0960-894x(01)00159-7
4209 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960697s
4893 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960697s
503 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960697s
5385 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960697s
CHEMBL2 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960697s
DB00457 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960697s
11532563 173158 0 None 6 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 453 14 1 7 4.3 COc1cccc(COc2ccccc2OCCNCCOc2c(OC)cccc2OC)c1 10.1021/jm0580398
CHEMBL427552 173158 0 None 6 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 453 14 1 7 4.3 COc1cccc(COc2ccccc2OCCNCCOc2c(OC)cccc2OC)c1 10.1021/jm0580398
4209 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
4893 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
503 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
5385 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
CHEMBL2 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
DB00457 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
49781447 24616 0 None -3 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 391 2 0 6 3.5 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ncn(C)n4)cc32)CC1 10.1021/jm100652h
CHEMBL1258988 24616 0 None -3 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 391 2 0 6 3.5 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ncn(C)n4)cc32)CC1 10.1021/jm100652h
4209 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
4893 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
503 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
5385 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
CHEMBL2 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
DB00457 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 nan
50905585 63125 0 None 1 3 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 470 12 2 6 3.5 COc1ccc(C[C@@H](C)NCCOc2ccccc2OCc2ccccc2)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
CHEMBL1630939 63125 0 None 1 3 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 470 12 2 6 3.5 COc1ccc(C[C@@H](C)NCCOc2ccccc2OCc2ccccc2)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
3157 8252 71 None -1 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1016/j.ejmech.2017.05.003
7170 8252 71 None -1 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1016/j.ejmech.2017.05.003
954 8252 71 None -1 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1016/j.ejmech.2017.05.003
CHEMBL707 8252 71 None -1 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1016/j.ejmech.2017.05.003
DB00590 8252 71 None -1 12 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1016/j.ejmech.2017.05.003
4209 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(99)00484-9
4893 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(99)00484-9
503 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(99)00484-9
5385 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(99)00484-9
CHEMBL2 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(99)00484-9
DB00457 9937 75 None 1 33 Human 9.5 pKi = 9.5 Binding
Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/s0960-894x(99)00484-9
145956955 168880 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 397 5 2 8 2.2 COc1cc2nc(N3CCC[C@H](NC(=O)c4ccco4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
CHEMBL4161165 168880 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 397 5 2 8 2.2 COc1cc2nc(N3CCC[C@H](NC(=O)c4ccco4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
11505007 175702 0 None 3 4 Human 9.5 pKi = 9.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 557 9 1 7 4.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL438673 175702 0 None 3 4 Human 9.5 pKi = 9.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 557 9 1 7 4.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
10657835 127192 1 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 242 2 1 2 2.8 Brc1ccsc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL1203850 127192 1 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 242 2 1 2 2.8 Brc1ccsc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL353666 127192 1 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 242 2 1 2 2.8 Brc1ccsc1Cc1c[nH]cn1 10.1021/jm0003891
9847196 36954 0 None -1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sc(-c4ccccc4)cc3c2=O)CC1 10.1016/s0960-894x(01)00159-7
CHEMBL13903 36954 0 None -1 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 462 6 1 7 3.2 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sc(-c4ccccc4)cc3c2=O)CC1 10.1016/s0960-894x(01)00159-7
4013695 108792 20 None -1 5 Human 9.4 pKi = 9.4 Binding
Binding affinity to adrenergic Alpha-1D receptorBinding affinity to adrenergic Alpha-1D receptor
ChEMBL 419 5 2 6 2.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL301707 108792 20 None -1 5 Human 9.4 pKi = 9.4 Binding
Binding affinity to adrenergic Alpha-1D receptorBinding affinity to adrenergic Alpha-1D receptor
ChEMBL 419 5 2 6 2.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.03.054
4013695 108792 20 None -1 5 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 419 5 2 6 2.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL301707 108792 20 None -1 5 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 419 5 2 6 2.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.ejmech.2011.03.054
4013695 108792 20 None -1 5 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 419 5 2 6 2.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL301707 108792 20 None -1 5 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 419 5 2 6 2.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
9887458 202452 0 None 70 4 Rat 9.4 pKi = 9.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 403 4 0 4 3.5 Cc1ccc(Cl)cc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL55654 202452 0 None 70 4 Rat 9.4 pKi = 9.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 403 4 0 4 3.5 Cc1ccc(Cl)cc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
11303253 205376 0 None 6 4 Rat 9.4 pKi = 9.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 371 5 0 4 3.0 COc1ccccc1N1CCN(CCN2CCC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL57859 205376 0 None 6 4 Rat 9.4 pKi = 9.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 371 5 0 4 3.0 COc1ccccc1N1CCN(CCN2CCC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
49781894 24678 0 None 1 4 Rat 9.4 pKi = 9.4 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 423 3 1 4 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(CNC(=O)C(C)(C)C)cc32)CC1 10.1021/jm100652h
CHEMBL1259158 24678 0 None 1 4 Rat 9.4 pKi = 9.4 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 423 3 1 4 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(CNC(=O)C(C)(C)C)cc32)CC1 10.1021/jm100652h
10742076 107094 0 None 1 3 Rat 9.4 pKi = 9.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
CHEMBL289361 107094 0 None 1 3 Rat 9.4 pKi = 9.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
10411384 163943 0 None 1 3 Rat 9.4 pKi = 9.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cnccc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL40754 163943 0 None 1 3 Rat 9.4 pKi = 9.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cnccc54)c3=O)C[C@@H]21 10.1021/jm990567u
90645596 119265 0 None 2 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 640 11 3 9 3.8 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCC(=O)NCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298749 119265 0 None 2 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 640 11 3 9 3.8 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCC(=O)NCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
10549596 91380 1 None -1 7 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153553 91380 1 None -1 7 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2221147 91380 1 None -1 7 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1 10.1016/j.ejmech.2012.09.049
52945803 23838 0 None 2 4 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 451 15 1 6 5.1 CCOc1cccc(OCC)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1254742 23838 0 None 2 4 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 451 15 1 6 5.1 CCOc1cccc(OCC)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
69782867 168362 0 None -2 6 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 549 8 1 9 4.4 COc1cc2nc(N3CCN(C(=O)COc4c(OC)cccc4C(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4129291 168362 0 None -2 6 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 549 8 1 9 4.4 COc1cc2nc(N3CCN(C(=O)COc4c(OC)cccc4C(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
11430491 69775 0 None -1 6 Human 9.4 pKi = 9.4 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 435 5 1 9 2.4 COc1cc2nc(N3CCN(C(=O)CC4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
CHEMBL178673 69775 0 None -1 6 Human 9.4 pKi = 9.4 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 435 5 1 9 2.4 COc1cc2nc(N3CCN(C(=O)CC4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
10583912 127592 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1cscc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL1744271 127592 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1cscc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL355699 127592 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1cscc1C(C)c1c[nH]cn1 10.1021/jm0003891
44420428 90269 0 None 3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 434 5 0 7 3.8 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL220221 90269 0 None 3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 434 5 0 7 3.8 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
44420428 90269 0 None 3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 434 5 0 7 3.8 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL220221 90269 0 None 3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 434 5 0 7 3.8 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
122179430 128219 0 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 599 8 1 13 2.7 CCN(CC)c1ccc2cc(-n3cc(C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 10.1021/ml5004298
CHEMBL3582270 128219 0 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 599 8 1 13 2.7 CCN(CC)c1ccc2cc(-n3cc(C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 10.1021/ml5004298
10822829 172344 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 220 4 1 2 3.2 CCc1cc(Cc2c[nH]cn2)c(CC)s1 10.1021/jm0003891
CHEMBL1744276 172344 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 220 4 1 2 3.2 CCc1cc(Cc2c[nH]cn2)c(CC)s1 10.1021/jm0003891
CHEMBL424210 172344 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 220 4 1 2 3.2 CCc1cc(Cc2c[nH]cn2)c(CC)s1 10.1021/jm0003891
10971791 215097 0 None 7 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 417 5 1 7 3.4 COc1ccccc1N1CCN(CCn2c(C)nc3c4ccccc4nc-3c2O)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL99142 215097 0 None 7 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 417 5 1 7 3.4 COc1ccccc1N1CCN(CCn2c(C)nc3c4ccccc4nc-3c2O)CC1 10.1016/j.bmcl.2006.09.034
10527466 209466 0 None 1 3 Rat 9.4 pKi = 9.4 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 448 5 2 6 2.3 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(NC(C)=O)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL61598 209466 0 None 1 3 Rat 9.4 pKi = 9.4 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 448 5 2 6 2.3 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(NC(C)=O)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
11464777 108582 0 None 32 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 437 4 0 4 4.2 CC(CN1CCN(c2cc(Cl)ccc2Cl)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
CHEMBL300152 108582 0 None 32 5 Rat 9.4 pKi = 9.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 437 4 0 4 4.2 CC(CN1CCN(c2cc(Cl)ccc2Cl)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
11092254 212245 0 None -1 4 Human 9.4 pKi = 9.4 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 495 8 1 8 3.5 COc1ccc(Cl)cc1N1CCN(CCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL80458 212245 0 None -1 4 Human 9.4 pKi = 9.4 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 495 8 1 8 3.5 COc1ccc(Cl)cc1N1CCN(CCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
4209 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
4893 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
503 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
5385 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
CHEMBL2 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
DB00457 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
10074286 212283 0 None -2 4 Human 9.4 pKi = 9.4 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 489 9 1 8 3.5 COc1ccccc1N1CCN(CCNc2c(C(=O)C(C)C)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL80730 212283 0 None -2 4 Human 9.4 pKi = 9.4 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 489 9 1 8 3.5 COc1ccccc1N1CCN(CCNc2c(C(=O)C(C)C)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
4209 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
4893 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
503 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
5385 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
CHEMBL2 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
DB00457 9937 75 None 1 33 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]Prazosin from human recombinant alpha1D adrenergic receptor expressed in HEK293 cells after 60 mins
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.01.025
10783054 127493 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 334 2 1 2 4.1 CC(c1c[nH]cn1)c1scc(Br)c1Br 10.1021/jm0003891
CHEMBL1744280 127493 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 334 2 1 2 4.1 CC(c1c[nH]cn1)c1scc(Br)c1Br 10.1021/jm0003891
CHEMBL354729 127493 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 334 2 1 2 4.1 CC(c1c[nH]cn1)c1scc(Br)c1Br 10.1021/jm0003891
44289248 175755 0 None -4 7 Human 9.4 pKi = 9.4 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 435 9 1 5 5.4 COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2S1 10.1021/jm011066n
CHEMBL43905 175755 0 None -4 7 Human 9.4 pKi = 9.4 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 435 9 1 5 5.4 COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2S1 10.1021/jm011066n
10726009 65972 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1sccc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL170134 65972 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1sccc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL1744294 65972 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1sccc1Cc1c[nH]cn1 10.1021/jm0003891
9837285 65805 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1ccsc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL1203848 65805 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1ccsc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL169339 65805 1 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1ccsc1Cc1c[nH]cn1 10.1021/jm0003891
4209 9937 75 None 1 33 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
4893 9937 75 None 1 33 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
503 9937 75 None 1 33 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
5385 9937 75 None 1 33 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
CHEMBL2 9937 75 None 1 33 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
DB00457 9937 75 None 1 33 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1016/j.bmcl.2013.12.024
9847845 35226 0 None -1 6 Human 9.3 pKi = 9.3 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sc(C)c(-c4ccccc4)c3c2=O)CC1 10.1016/s0960-894x(01)00159-7
CHEMBL13754 35226 0 None -1 6 Human 9.3 pKi = 9.3 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 476 6 1 7 3.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sc(C)c(-c4ccccc4)c3c2=O)CC1 10.1016/s0960-894x(01)00159-7
6603950 210103 9 None 1 8 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 344 1 0 3 4.3 CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm020938y
CHEMBL64875 210103 9 None 1 8 Rat 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 344 1 0 3 4.3 CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm020938y
10631172 66341 2 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1cscc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL171772 66341 2 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1cscc1Cc1c[nH]cn1 10.1021/jm0003891
CHEMBL1744291 66341 2 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1cscc1Cc1c[nH]cn1 10.1021/jm0003891
24894147 202660 0 None 2 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1021/jm8016046
CHEMBL558890 202660 0 None 2 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1021/jm8016046
10834793 91354 0 None 1 7 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 363 8 1 6 2.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153557 91354 0 None 1 7 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 363 8 1 6 2.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2220925 91354 0 None 1 7 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 363 8 1 6 2.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1 10.1016/j.ejmech.2012.09.049
11430126 67337 0 None 1 6 Human 9.3 pKi = 9.3 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 421 4 1 9 2.0 COc1cc2nc(N3CCN(C(=O)C4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
CHEMBL175934 67337 0 None 1 6 Human 9.3 pKi = 9.3 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 421 4 1 9 2.0 COc1cc2nc(N3CCN(C(=O)C4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
10961351 170280 0 None -1 4 Human 9.3 pKi = 9.3 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 449 7 1 7 3.0 CC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2F)CC1 10.1021/jm0009336
CHEMBL420205 170280 0 None -1 4 Human 9.3 pKi = 9.3 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 449 7 1 7 3.0 CC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2F)CC1 10.1021/jm0009336
44431184 99625 0 None 2 3 Human 9.3 pKi = 9.3 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 515 5 0 5 5.5 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccc(F)cc5c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
CHEMBL243866 99625 0 None 2 3 Human 9.3 pKi = 9.3 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 515 5 0 5 5.5 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccc(F)cc5c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
10744687 107202 0 None 1 3 Rat 9.3 pKi = 9.3 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 490 5 2 7 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(C(N)=O)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL290388 107202 0 None 1 3 Rat 9.3 pKi = 9.3 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 490 5 2 7 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(C(N)=O)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
10527469 163044 3 None -1 16 Rat 9.3 pKi = 9.3 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL40650 163044 3 None -1 16 Rat 9.3 pKi = 9.3 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm990567u
499 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm011066n
5685 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm011066n
CHEMBL25554 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm011066n
499 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm021078o
5685 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm021078o
CHEMBL25554 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm021078o
13305910 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Antagonist activity at human alpha D1 adrenoreceptor expressed in CHO cellsAntagonist activity at human alpha D1 adrenoreceptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2020.112419
CHEMBL1182155 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Antagonist activity at human alpha D1 adrenoreceptor expressed in CHO cellsAntagonist activity at human alpha D1 adrenoreceptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2020.112419
CHEMBL215421 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Antagonist activity at human alpha D1 adrenoreceptor expressed in CHO cellsAntagonist activity at human alpha D1 adrenoreceptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2020.112419
CHEMBL3741808 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Antagonist activity at human alpha D1 adrenoreceptor expressed in CHO cellsAntagonist activity at human alpha D1 adrenoreceptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2020.112419
499 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm030952q
5685 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm030952q
CHEMBL25554 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm030952q
13305910 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182155 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL215421 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL3741808 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
499 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1016/j.bmc.2010.08.002
5685 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1016/j.bmc.2010.08.002
CHEMBL25554 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1016/j.bmc.2010.08.002
52942152 23839 0 None 2 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 438 13 1 7 4.2 COc1cccc([N+](=O)[O-])c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1254743 23839 0 None 2 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 438 13 1 7 4.2 COc1cccc([N+](=O)[O-])c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
13305910 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL1182155 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL215421 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL3741808 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
499 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm991065j
5685 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm991065j
CHEMBL25554 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm991065j
13305910 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL1182155 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL215421 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL3741808 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
499 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm800461k
5685 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm800461k
CHEMBL25554 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm800461k
499 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm301525w
5685 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm301525w
CHEMBL25554 10849 18 None -1 14 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm301525w
13305910 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm301525w
CHEMBL1182155 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm301525w
CHEMBL215421 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm301525w
CHEMBL3741808 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm301525w
13305910 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1039/C4MD00484A
CHEMBL1182155 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1039/C4MD00484A
CHEMBL215421 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1039/C4MD00484A
CHEMBL3741808 18608 1 None -2 9 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 10.1039/C4MD00484A
10678154 177380 0 None -1 3 Rat 9.3 pKi = 9.3 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 397 4 1 6 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cscc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL445071 177380 0 None -1 3 Rat 9.3 pKi = 9.3 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 397 4 1 6 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cscc4c3=O)C[C@@H]21 10.1021/jm000541z
2894 214850 6 None -1 6 Rat 9.3 pKi = 9.3 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)C4CCCCC43)nc(N)c2cc1OC 10.1021/jm960510x
CHEMBL97698 214850 6 None -1 6 Rat 9.3 pKi = 9.3 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)C4CCCCC43)nc(N)c2cc1OC 10.1021/jm960510x
11234230 108478 0 None 1 5 Rat 9.3 pKi = 9.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 375 4 0 3 3.6 O=C1CC2(CCCC2)CCN1CCN1CCN(c2ccccc2Cl)CC1 10.1021/jm030944+
CHEMBL299454 108478 0 None 1 5 Rat 9.3 pKi = 9.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 375 4 0 3 3.6 O=C1CC2(CCCC2)CCN1CCN1CCN(c2ccccc2Cl)CC1 10.1021/jm030944+
132266 8061 12 None -20 9 Rat 9.2 pKi = 9.2 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm960510x
486 8061 12 None -20 9 Rat 9.2 pKi = 9.2 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm960510x
CHEMBL423294 8061 12 None -20 9 Rat 9.2 pKi = 9.2 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm960510x
90645592 119261 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 555 7 2 8 4.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)c5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298745 119261 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 555 7 2 8 4.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)c5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
10844296 208194 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 425 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(Cl)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL60471 208194 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 425 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(Cl)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
10767959 167725 0 None 2 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 472 4 1 7 3.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(C#N)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL41155 167725 0 None 2 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 472 4 1 7 3.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(C#N)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
121102 150744 2 None 3 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 370 8 0 5 3.5 CCOc1ccccc1N1CCN(CCc2ccc(OC)c(OC)c2)CC1 10.1016/j.ejmech.2016.06.052
CHEMBL3902626 150744 2 None 3 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 370 8 0 5 3.5 CCOc1ccccc1N1CCN(CCc2ccc(OC)c(OC)c2)CC1 10.1016/j.ejmech.2016.06.052
49781449 24623 0 None -2 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 387 2 0 4 4.7 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccccn4)cc32)CC1 10.1021/jm100652h
CHEMBL1259006 24623 0 None -2 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 387 2 0 4 4.7 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccccn4)cc32)CC1 10.1021/jm100652h
10838523 107977 0 None -1 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 482 4 1 7 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(Cl)nc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL295741 107977 0 None -1 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 482 4 1 7 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(Cl)nc54)c3=O)C[C@@H]21 10.1021/jm990567u
10763038 209454 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 391 4 1 5 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ccccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL61491 209454 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 391 4 1 5 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ccccc4c3=O)C[C@@H]21 10.1021/jm000541z
10742076 107094 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
CHEMBL289361 107094 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
10698013 107216 0 None -2 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 518 5 1 7 3.3 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(C(=O)N(C)C)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL290519 107216 0 None -2 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 518 5 1 7 3.3 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(C(=O)N(C)C)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
44431602 151719 0 None 6 4 Human 9.2 pKi = 9.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 525 7 1 5 5.2 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL391035 151719 0 None 6 4 Human 9.2 pKi = 9.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 525 7 1 5 5.2 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2007.04.008
49782794 24688 0 None -2 6 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 409 4 1 4 4.0 CC(C)C(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
CHEMBL1259189 24688 0 None -2 6 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 409 4 1 4 4.0 CC(C)C(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
10504673 209452 0 None -1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 473 5 1 6 4.1 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(-c5ccccc5)csc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL61483 209452 0 None -1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 473 5 1 6 4.1 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(-c5ccccc5)csc4c3=O)C[C@@H]21 10.1021/jm000541z
44469973 146480 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 309 3 2 3 3.0 CC(c1cccc(Cl)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
CHEMBL3798124 146480 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 309 3 2 3 3.0 CC(c1cccc(Cl)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
2435 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm020938y
60149 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm020938y
98 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm020938y
CHEMBL12713 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm020938y
DB06144 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm020938y
2435 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1016/j.bmc.2012.10.049
60149 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1016/j.bmc.2012.10.049
98 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1016/j.bmc.2012.10.049
CHEMBL12713 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1016/j.bmc.2012.10.049
DB06144 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1016/j.bmc.2012.10.049
2435 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm100652h
60149 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm100652h
98 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm100652h
CHEMBL12713 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm100652h
DB06144 10362 83 None -4 48 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O 10.1021/jm100652h
49781451 24630 0 None 1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 387 2 0 4 4.7 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccncc4)cc32)CC1 10.1021/jm100652h
CHEMBL1259024 24630 0 None 1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 387 2 0 4 4.7 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccncc4)cc32)CC1 10.1021/jm100652h
11270912 206371 0 None 2 5 Rat 9.2 pKi = 9.2 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 451 6 0 4 4.6 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL59262 206371 0 None 2 5 Rat 9.2 pKi = 9.2 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 451 6 0 4 4.6 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
44431560 152356 0 None 2 4 Human 9.2 pKi = 9.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL391530 152356 0 None 2 4 Human 9.2 pKi = 9.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
10789770 107662 0 None -3 5 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 451 6 1 7 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)c(OC)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL293695 107662 0 None -3 5 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 451 6 1 7 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)c(OC)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
10502807 169924 0 None 3 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 431 4 1 6 3.1 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4c(oc5ccccc54)c3=O)CC21 10.1021/jm990567u
CHEMBL417890 169924 0 None 3 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 431 4 1 6 3.1 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4c(oc5ccccc54)c3=O)CC21 10.1021/jm990567u
10741071 175996 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 425 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cccc(Cl)c4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL440865 175996 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 425 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cccc(Cl)c4c3=O)C[C@@H]21 10.1021/jm000541z
9932698 24681 0 None -3 6 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 435 6 2 4 3.4 NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 10.1021/jm100652h
CHEMBL1259172 24681 0 None -3 6 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 435 6 2 4 3.4 NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 10.1021/jm100652h
10797836 127176 2 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.7 Cc1cc(Cc2c[nH]cn2)c(C)s1 10.1021/jm0003891
CHEMBL1744277 127176 2 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.7 Cc1cc(Cc2c[nH]cn2)c(C)s1 10.1021/jm0003891
CHEMBL353505 127176 2 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.7 Cc1cc(Cc2c[nH]cn2)c(C)s1 10.1021/jm0003891
10718317 107302 0 None -1 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncccc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL291262 107302 0 None -1 3 Rat 9.2 pKi = 9.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncccc54)c3=O)C[C@@H]21 10.1021/jm990567u
71462043 91343 0 None -1 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 379 8 1 6 3.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153555 91343 0 None -1 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 379 8 1 6 3.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2220895 91343 0 None -1 7 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 379 8 1 6 3.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1 10.1016/j.ejmech.2012.09.049
10740369 208642 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 411 4 1 6 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)csc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL60721 208642 0 None 1 3 Rat 9.2 pKi = 9.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 411 4 1 6 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)csc4c3=O)C[C@@H]21 10.1021/jm000541z
9891166 40386 0 None -1 5 Rat 9.2 pKi = 9.2 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 476 6 0 8 3.3 COc1ccccc1N1CCN(CCn2c(=O)c3c(-c4ccccc4)csc3n(C)c2=O)CC1 10.1016/s0960-894x(01)00159-7
CHEMBL14213 40386 0 None -1 5 Rat 9.2 pKi = 9.2 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 476 6 0 8 3.3 COc1ccccc1N1CCN(CCn2c(=O)c3c(-c4ccccc4)csc3n(C)c2=O)CC1 10.1016/s0960-894x(01)00159-7
10344976 107992 2 None -1 6 Human 9.1 pKi = 9.1 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 477 11 1 10 3.4 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1021/jm9810654
CHEMBL29591 107992 2 None -1 6 Human 9.1 pKi = 9.1 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 477 11 1 10 3.4 COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC 10.1021/jm9810654
10606657 208267 0 None 1 3 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 419 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C)c(C)cc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL60510 208267 0 None 1 3 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 419 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C)c(C)cc4c3=O)C[C@@H]21 10.1021/jm000541z
10765077 107038 0 None 1 3 Rat 9.1 pKi = 9.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 430 4 2 5 2.8 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC21 10.1021/jm990567u
CHEMBL288809 107038 0 None 1 3 Rat 9.1 pKi = 9.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 430 4 2 5 2.8 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC21 10.1021/jm990567u
10839391 164149 0 None -1 3 Rat 9.1 pKi = 9.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 472 4 1 7 3.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cc(C#N)ccc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL40780 164149 0 None -1 3 Rat 9.1 pKi = 9.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 472 4 1 7 3.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cc(C#N)ccc54)c3=O)C[C@@H]21 10.1021/jm990567u
52940951 23851 0 None 3 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 427 12 1 5 5.0 COc1cccc(Cl)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1254828 23851 0 None 3 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 427 12 1 5 5.0 COc1cccc(Cl)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
17753379 94578 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 521 8 1 6 4.5 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233816 94578 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 521 8 1 6 4.5 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
10655911 127083 1 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 2 1 2 3.2 Cc1csc(C(C)c2c[nH]cn2)c1C 10.1021/jm0003891
CHEMBL1744281 127083 1 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 2 1 2 3.2 Cc1csc(C(C)c2c[nH]cn2)c1C 10.1021/jm0003891
CHEMBL352752 127083 1 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 2 1 2 3.2 Cc1csc(C(C)c2c[nH]cn2)c1C 10.1021/jm0003891
90645605 119215 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 666 13 2 9 5.2 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCC(=O)NCCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298023 119215 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 666 13 2 9 5.2 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCC(=O)NCCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
11857638 150588 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 516 9 1 6 5.0 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL390129 150588 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 516 9 1 6 5.0 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
10647175 138233 0 None -2 3 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 449 5 1 7 2.1 COC(=O)c1ccc2c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)[nH]c2c1 10.1021/jm000541z
CHEMBL369154 138233 0 None -2 3 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 449 5 1 7 2.1 COC(=O)c1ccc2c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)[nH]c2c1 10.1021/jm000541z
10693231 209541 0 None -5 5 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 416 4 1 6 2.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C#N)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL62033 209541 0 None -5 5 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 416 4 1 6 2.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C#N)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
9913988 24687 0 None -1 4 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 502 7 1 7 3.1 Cn1nnc(Cc2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm100652h
CHEMBL1259188 24687 0 None -1 4 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 502 7 1 7 3.1 Cn1nnc(Cc2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm100652h
1238 209953 24 None -3 16 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm100652h
CHEMBL64249 209953 24 None -3 16 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 10.1021/jm100652h
2419 7482 28 None -1 11 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(01)00159-7
9 7482 28 None -1 11 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(01)00159-7
CHEMBL13647 7482 28 None -1 11 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(01)00159-7
10487999 66172 5 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1ccsc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL1237160 66172 5 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1ccsc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL170960 66172 5 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1ccsc1C(C)c1c[nH]cn1 10.1021/jm0003891
4209 9937 75 None -2 33 Rat 9.1 pKi = 9.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
4893 9937 75 None -2 33 Rat 9.1 pKi = 9.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
503 9937 75 None -2 33 Rat 9.1 pKi = 9.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
5385 9937 75 None -2 33 Rat 9.1 pKi = 9.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
CHEMBL2 9937 75 None -2 33 Rat 9.1 pKi = 9.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
DB00457 9937 75 None -2 33 Rat 9.1 pKi = 9.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm00018a001
499 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm00018a001
5685 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm00018a001
CHEMBL25554 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm00018a001
44431587 94609 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 565 8 1 6 4.7 COc1ccc(Br)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233849 94609 0 None 1 4 Human 9.1 pKi = 9.1 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 565 8 1 6 4.7 COc1ccc(Br)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
44431194 99335 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 448 5 0 6 3.6 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccncc4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
CHEMBL243229 99335 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 448 5 0 6 3.6 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccncc4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
52949448 23433 0 None -3 4 Human 9.1 pKi = 9.1 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 430 6 0 5 4.1 COc1ccccc1N1CCN(CC2OCC(c3ccccc3)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242352 23433 0 None -3 4 Human 9.1 pKi = 9.1 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 430 6 0 5 4.1 COc1ccccc1N1CCN(CC2OCC(c3ccccc3)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
3157 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm0580398
7170 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm0580398
954 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm0580398
CHEMBL707 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm0580398
DB00590 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm0580398
3157 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
7170 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
954 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
CHEMBL707 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
DB00590 8252 71 None -1 12 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm8016046
57393527 78333 0 None -3 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 430 6 0 5 4.1 COc1ccccc1N1CCN(CC2COC(c3ccccc3)(c3ccccc3)O2)CC1 10.1021/jm200421e
CHEMBL1946777 78333 0 None -3 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 430 6 0 5 4.1 COc1ccccc1N1CCN(CC2COC(c3ccccc3)(c3ccccc3)O2)CC1 10.1021/jm200421e
CHEMBL1963046 78333 0 None -3 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 430 6 0 5 4.1 COc1ccccc1N1CCN(CC2COC(c3ccccc3)(c3ccccc3)O2)CC1 10.1021/jm200421e
57393527 78333 0 None -3 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 430 6 0 5 4.1 COc1ccccc1N1CCN(CC2COC(c3ccccc3)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2016.09.050
CHEMBL1946777 78333 0 None -3 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 430 6 0 5 4.1 COc1ccccc1N1CCN(CC2COC(c3ccccc3)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2016.09.050
CHEMBL1963046 78333 0 None -3 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 430 6 0 5 4.1 COc1ccccc1N1CCN(CC2COC(c3ccccc3)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2016.09.050
9864325 108515 1 None 1 6 Human 9.1 pKi = 9.1 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 373 4 0 4 2.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2F)CC1 10.1021/jm0491391
CHEMBL299691 108515 1 None 1 6 Human 9.1 pKi = 9.1 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 373 4 0 4 2.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2F)CC1 10.1021/jm0491391
44300018 205072 0 None 5 4 Rat 9.1 pKi = 9.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 389 4 0 4 3.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 10.1021/jm030944+
CHEMBL57593 205072 0 None 5 4 Rat 9.1 pKi = 9.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 389 4 0 4 3.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 10.1021/jm030944+
44420431 91512 0 None 4 3 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 468 5 0 7 4.4 COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL222896 91512 0 None 4 3 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 468 5 0 7 4.4 COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
11372228 108444 0 None 11 5 Rat 9.1 pKi = 9.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 373 4 0 3 3.8 O=C1CC2(C=CN1CCN1CCN(c3ccccc3Cl)CC1)CCCC2 10.1021/jm030944+
CHEMBL299253 108444 0 None 11 5 Rat 9.1 pKi = 9.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 373 4 0 3 3.8 O=C1CC2(C=CN1CCN1CCN(c3ccccc3Cl)CC1)CCCC2 10.1021/jm030944+
3584 10549 64 None -1 14 Human 9.1 pKi = 9.1 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
5401 10549 64 None -1 14 Human 9.1 pKi = 9.1 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
7302 10549 64 None -1 14 Human 9.1 pKi = 9.1 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
CHEMBL611 10549 64 None -1 14 Human 9.1 pKi = 9.1 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
DB01162 10549 64 None -1 14 Human 9.1 pKi = 9.1 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm970364a
49832191 174318 0 None 407 3 Human 9.1 pKi = 9.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 382 6 2 5 2.9 CNc1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4218307 174318 0 None 407 3 Human 9.1 pKi = 9.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 382 6 2 5 2.9 CNc1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4300210 174318 0 None 407 3 Human 9.1 pKi = 9.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 382 6 2 5 2.9 CNc1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
25025244 146874 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 320 3 2 4 2.3 N#Cc1cc(Cl)cc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3800606 146874 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 320 3 2 4 2.3 N#Cc1cc(Cl)cc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
2894 214850 6 None -1 6 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)C4CCCCC43)nc(N)c2cc1OC 10.1021/jm020938y
CHEMBL97698 214850 6 None -1 6 Rat 9.1 pKi = 9.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)C4CCCCC43)nc(N)c2cc1OC 10.1021/jm020938y
10696645 150900 0 None 1 3 Rat 9.1 pKi = 9.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 461 4 1 6 3.9 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccc(C)c54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL39037 150900 0 None 1 3 Rat 9.1 pKi = 9.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 461 4 1 6 3.9 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccc(C)c54)c3=O)C[C@@H]21 10.1021/jm990567u
2585 7590 103 None -4 22 Human 9.1 pKi = 9.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
522 7590 103 None -4 22 Human 9.1 pKi = 9.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
551 7590 103 None -4 22 Human 9.1 pKi = 9.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
CHEMBL723 7590 103 None -4 22 Human 9.1 pKi = 9.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
DB01136 7590 103 None -4 22 Human 9.1 pKi = 9.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O nan
10716965 174739 0 None -10 3 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 419 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)c(C)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL431720 174739 0 None -10 3 Rat 9.1 pKi = 9.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 419 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)c(C)ccc4c3=O)C[C@@H]21 10.1021/jm000541z
11454386 69881 0 None 1 6 Human 9.1 pKi = 9.1 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 477 8 1 9 3.6 COc1cc2nc(N3CCN(C(=O)CCCCC4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
CHEMBL178923 69881 0 None 1 6 Human 9.1 pKi = 9.1 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 477 8 1 9 3.6 COc1cc2nc(N3CCN(C(=O)CCCCC4CCSS4)CC3)nc(N)c2cc1OC 10.1021/jm049153d
9864325 108515 1 None -1 6 Rat 9.0 pKi = 9.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 373 4 0 4 2.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2F)CC1 10.1021/jm030944+
CHEMBL299691 108515 1 None -1 6 Rat 9.0 pKi = 9.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 373 4 0 4 2.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2F)CC1 10.1021/jm030944+
90645593 119262 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 569 8 2 8 3.9 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)Cc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298746 119262 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 569 8 2 8 3.9 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)Cc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
11619713 79592 0 None 2 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 468 14 1 8 4.2 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1[N+](=O)[O-] 10.1021/jm0580398
CHEMBL200136 79592 0 None 2 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 468 14 1 8 4.2 COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1[N+](=O)[O-] 10.1021/jm0580398
52943356 23852 0 None 2 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 407 12 1 5 4.6 COc1cccc(C)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1254829 23852 0 None 2 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 407 12 1 5 4.6 COc1cccc(C)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
118716718 121790 0 None 3 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 532 7 0 9 2.3 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4cccc([N+](=O)[O-])c4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342871 121790 0 None 3 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 532 7 0 9 2.3 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4cccc([N+](=O)[O-])c4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
71454559 86419 0 None 1 3 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 397 4 1 6 2.4 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4ccsc4c3=O)CC21 10.1021/jm000541z
CHEMBL2115086 86419 0 None 1 3 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 397 4 1 6 2.4 COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4ccsc4c3=O)CC21 10.1021/jm000541z
10692195 107382 0 None 1 3 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 397 4 1 6 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ccsc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL291839 107382 0 None 1 3 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 397 4 1 6 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ccsc4c3=O)C[C@@H]21 10.1021/jm000541z
11176459 108414 0 None 5 5 Rat 9.0 pKi = 9.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 380 4 0 5 2.4 N#Cc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL299022 108414 0 None 5 5 Rat 9.0 pKi = 9.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 380 4 0 5 2.4 N#Cc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
44294569 108796 0 None 5 4 Human 9.0 pKi = 9.0 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 447 7 1 8 2.5 COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c(C(C)=O)c(N)c2=O)CC1 10.1021/jm981006q
CHEMBL301726 108796 0 None 5 4 Human 9.0 pKi = 9.0 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 447 7 1 8 2.5 COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c(C(C)=O)c(N)c2=O)CC1 10.1021/jm981006q
11751173 70200 0 None -1 6 Human 9.0 pKi = 9.0 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 445 4 1 9 2.3 COc1cc2nc(N3CCN(C4=CC(=O)c5ccccc5C4=O)CC3)nc(N)c2cc1OC 10.1021/jm049153d
CHEMBL179743 70200 0 None -1 6 Human 9.0 pKi = 9.0 Binding
Equilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cellsEquilibrium dissociation constant was evaluated by radio-receptor binding assays using [3H]prazosin to label cloned human alpha 1d expressed in CHO cells
ChEMBL 445 4 1 9 2.3 COc1cc2nc(N3CCN(C4=CC(=O)c5ccccc5C4=O)CC3)nc(N)c2cc1OC 10.1021/jm049153d
10095156 85318 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL2112073 85318 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)C[C@@H]21 10.1021/jm990567u
9908478 202415 1 None -6 7 Human 9.0 pKi = 9.0 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 391 4 0 4 2.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)ccc2F)CC1 10.1021/jm0491391
CHEMBL556313 202415 1 None -6 7 Human 9.0 pKi = 9.0 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 391 4 0 4 2.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)ccc2F)CC1 10.1021/jm0491391
6761 74574 19 None -1 18 Human 9.0 pKi = 9.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 nan
CHEMBL1909072 74574 19 None -1 18 Human 9.0 pKi = 9.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 nan
24897950 63126 0 None -3 6 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 462 11 2 6 2.9 COc1ccc(C[C@@H](C)NCCOc2ccccc2OCC(F)(F)F)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
CHEMBL1630940 63126 0 None -3 6 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 462 11 2 6 2.9 COc1ccc(C[C@@H](C)NCCOc2ccccc2OCC(F)(F)F)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
2419 7482 28 None -3 11 Rat 9.0 pKi = 9.0 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(01)00159-7
9 7482 28 None -3 11 Rat 9.0 pKi = 9.0 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(01)00159-7
CHEMBL13647 7482 28 None -3 11 Rat 9.0 pKi = 9.0 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/s0960-894x(01)00159-7
10706270 127600 1 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 256 2 1 2 3.4 CC(c1c[nH]cn1)c1sccc1Br 10.1021/jm0003891
CHEMBL1237159 127600 1 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 256 2 1 2 3.4 CC(c1c[nH]cn1)c1sccc1Br 10.1021/jm0003891
CHEMBL355784 127600 1 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 256 2 1 2 3.4 CC(c1c[nH]cn1)c1sccc1Br 10.1021/jm0003891
10527469 163044 3 None -2 16 Human 9.0 pKi = 9.0 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm970364a
CHEMBL40650 163044 3 None -2 16 Human 9.0 pKi = 9.0 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
ChEMBL 448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 10.1021/jm970364a
49781234 24701 0 None -3 4 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 390 2 0 5 4.1 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccnn4C)cc32)CC1 10.1021/jm100652h
CHEMBL1259231 24701 0 None -3 4 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 390 2 0 5 4.1 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccnn4C)cc32)CC1 10.1021/jm100652h
10632119 65891 2 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 3 1 2 3.3 CCC(c1c[nH]cn1)c1cscc1C 10.1021/jm0003891
CHEMBL169804 65891 2 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 3 1 2 3.3 CCC(c1c[nH]cn1)c1cscc1C 10.1021/jm0003891
CHEMBL1744287 65891 2 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 3 1 2 3.3 CCC(c1c[nH]cn1)c1cscc1C 10.1021/jm0003891
11857793 92425 0 None 6 4 Human 9.0 pKi = 9.0 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 548 7 1 4 5.9 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.098
CHEMBL228445 92425 0 None 6 4 Human 9.0 pKi = 9.0 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 548 7 1 4 5.9 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.098
49782792 24683 0 None -2 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 381 3 1 4 3.3 CC(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
CHEMBL1259174 24683 0 None -2 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 381 3 1 4 3.3 CC(=O)NCc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
44431560 152356 0 None 2 4 Human 9.0 pKi = 9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.008
CHEMBL391530 152356 0 None 2 4 Human 9.0 pKi = 9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.008
90645599 119209 0 None 1 3 Human 9.0 pKi = 9 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 668 13 3 9 4.2 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)NCCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298017 119209 0 None 1 3 Human 9.0 pKi = 9 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 668 13 3 9 4.2 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)NCCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
49781450 24629 0 None -5 4 Rat 9.0 pKi = 9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 387 2 0 4 4.7 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4cccnc4)cc32)CC1 10.1021/jm100652h
CHEMBL1259023 24629 0 None -5 4 Rat 9.0 pKi = 9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 387 2 0 4 4.7 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4cccnc4)cc32)CC1 10.1021/jm100652h
49781232 24696 0 None -6 5 Rat 9.0 pKi = 9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 392 2 0 7 2.9 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4nnn(C)n4)cc32)CC1 10.1021/jm100652h
CHEMBL1259216 24696 0 None -6 5 Rat 9.0 pKi = 9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 392 2 0 7 2.9 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4nnn(C)n4)cc32)CC1 10.1021/jm100652h
10644505 107541 0 None 1 3 Rat 9.0 pKi = 9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 397 4 1 6 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4sccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL292881 107541 0 None 1 3 Rat 9.0 pKi = 9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 397 4 1 6 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4sccc4c3=O)C[C@@H]21 10.1021/jm000541z
3584 10549 64 None -1 14 Rat 9.0 pKi = 9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990567u
5401 10549 64 None -1 14 Rat 9.0 pKi = 9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990567u
7302 10549 64 None -1 14 Rat 9.0 pKi = 9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990567u
CHEMBL611 10549 64 None -1 14 Rat 9.0 pKi = 9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990567u
DB01162 10549 64 None -1 14 Rat 9.0 pKi = 9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990567u
155532835 183233 0 None -1 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 9 1 5 4.4 COc1ccccc1OCCNCC1CCOC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4467585 183233 0 None -1 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 9 1 5 4.4 COc1ccccc1OCCNCC1CCOC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4596417 183233 0 None -1 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 9 1 5 4.4 COc1ccccc1OCCNCC1CCOC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
10767626 162102 0 None 2 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 461 4 1 6 3.9 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(C)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL40310 162102 0 None 2 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 461 4 1 6 3.9 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc(C)cc54)c3=O)C[C@@H]21 10.1021/jm990567u
2419 7482 28 None -1 11 Human 9.0 pKi = 9.0 Binding
Binding affinity to adrenergic Alpha-1D receptorBinding affinity to adrenergic Alpha-1D receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2011.03.054
9 7482 28 None -1 11 Human 9.0 pKi = 9.0 Binding
Binding affinity to adrenergic Alpha-1D receptorBinding affinity to adrenergic Alpha-1D receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2011.03.054
CHEMBL13647 7482 28 None -1 11 Human 9.0 pKi = 9.0 Binding
Binding affinity to adrenergic Alpha-1D receptorBinding affinity to adrenergic Alpha-1D receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2011.03.054
10928520 212373 0 None -1 4 Human 9.0 pKi = 9.0 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 453 7 1 7 3.3 COc1ccc(Cl)cc1N1CCN(CCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL81486 212373 0 None -1 4 Human 9.0 pKi = 9.0 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 453 7 1 7 3.3 COc1ccc(Cl)cc1N1CCN(CCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
10625617 168475 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 477 5 1 7 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccc(OC)c54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL41344 168475 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 477 5 1 7 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccc(OC)c54)c3=O)C[C@@H]21 10.1021/jm990567u
44247584 146699 9 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 373 4 2 5 1.8 CS(=O)(=O)c1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
CHEMBL3799553 146699 9 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 373 4 2 5 1.8 CS(=O)(=O)c1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
145947545 174473 0 None 199 3 Human 9.0 pKi = 9.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 341 4 2 4 3.1 CSc1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N 10.1016/j.ejmech.2017.07.071
CHEMBL4208816 174473 0 None 199 3 Human 9.0 pKi = 9.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 341 4 2 4 3.1 CSc1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N 10.1016/j.ejmech.2017.07.071
CHEMBL4302269 174473 0 None 199 3 Human 9.0 pKi = 9.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 341 4 2 4 3.1 CSc1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N 10.1016/j.ejmech.2017.07.071
9920786 66205 2 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 214 2 1 2 3.2 c1ccc2sc(Cc3c[nH]cn3)cc2c1 10.1021/jm0003891
CHEMBL1203851 66205 2 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 214 2 1 2 3.2 c1ccc2sc(Cc3c[nH]cn3)cc2c1 10.1021/jm0003891
CHEMBL171100 66205 2 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 214 2 1 2 3.2 c1ccc2sc(Cc3c[nH]cn3)cc2c1 10.1021/jm0003891
10552656 168091 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 478 5 1 8 3.0 COc1ccc2sc3c(=O)n(CCN4C[C@@H]5CCc6c(OC)cccc6[C@@H]5C4)c(=O)[nH]c3c2n1 10.1021/jm990567u
CHEMBL41234 168091 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 478 5 1 8 3.0 COc1ccc2sc3c(=O)n(CCN4C[C@@H]5CCc6c(OC)cccc6[C@@H]5C4)c(=O)[nH]c3c2n1 10.1021/jm990567u
10743310 176011 0 None -3 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 479 5 1 9 2.4 COc1cnc2sc3c(=O)n(CCN4C[C@@H]5CCc6c(OC)cccc6[C@@H]5C4)c(=O)[nH]c3c2n1 10.1021/jm990567u
CHEMBL441032 176011 0 None -3 3 Rat 9.0 pKi = 9.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 479 5 1 9 2.4 COc1cnc2sc3c(=O)n(CCN4C[C@@H]5CCc6c(OC)cccc6[C@@H]5C4)c(=O)[nH]c3c2n1 10.1021/jm990567u
11200086 203203 0 None 1 4 Rat 9.0 pKi = 9.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 388 4 0 3 4.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCC(c2ccccc2Cl)CC1 10.1021/jm030944+
CHEMBL56292 203203 0 None 1 4 Rat 9.0 pKi = 9.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 388 4 0 3 4.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCC(c2ccccc2Cl)CC1 10.1021/jm030944+
10717073 209404 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 421 5 1 6 2.4 COc1ccc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2c1 10.1021/jm000541z
CHEMBL61225 209404 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 421 5 1 6 2.4 COc1ccc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2c1 10.1021/jm000541z
10621309 209554 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 405 4 1 5 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cccc(C)c4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL62110 209554 0 None -1 3 Rat 9.0 pKi = 9.0 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 405 4 1 5 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cccc(C)c4c3=O)C[C@@H]21 10.1021/jm000541z
25131876 92967 0 None -1 7 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.02.056
CHEMBL2312227 92967 0 None -1 7 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.02.056
25181488 194161 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm800461k
CHEMBL493486 194161 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm800461k
25131876 92967 0 None -1 7 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
CHEMBL2312227 92967 0 None -1 7 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
10740866 108872 0 None -1 3 Rat 8.9 pKi = 8.9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 421 5 1 6 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)cccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL302203 108872 0 None -1 3 Rat 8.9 pKi = 8.9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 421 5 1 6 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)cccc4c3=O)C[C@@H]21 10.1021/jm000541z
90645595 119264 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 611 11 2 8 5.1 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298748 119264 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 611 11 2 8 5.1 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
3157 8252 71 None -1 12 Human 8.9 pKi = 8.9 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm00018a001
7170 8252 71 None -1 12 Human 8.9 pKi = 8.9 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm00018a001
954 8252 71 None -1 12 Human 8.9 pKi = 8.9 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm00018a001
CHEMBL707 8252 71 None -1 12 Human 8.9 pKi = 8.9 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm00018a001
DB00590 8252 71 None -1 12 Human 8.9 pKi = 8.9 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm00018a001
499 10849 18 None -7 14 Rat 8.9 pKi = 8.9 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm00018a001
5685 10849 18 None -7 14 Rat 8.9 pKi = 8.9 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm00018a001
CHEMBL25554 10849 18 None -7 14 Rat 8.9 pKi = 8.9 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm00018a001
10503057 109398 0 None -1 3 Rat 8.9 pKi = 8.9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 436 5 1 7 2.3 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc([N+](=O)[O-])ccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL304215 109398 0 None -1 3 Rat 8.9 pKi = 8.9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 436 5 1 7 2.3 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc([N+](=O)[O-])ccc4c3=O)C[C@@H]21 10.1021/jm000541z
16041629 102221 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL257097 102221 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
10946567 23241 0 None 12 6 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 265 1 0 2 4.1 CCc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm00019a001
CHEMBL123448 23241 0 None 12 6 Human 8.9 pKi = 8.9 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 265 1 0 2 4.1 CCc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm00019a001
4418 40996 85 None 1 7 Human 8.9 pKi = 8.9 Binding
Displacement of [125I-HEAT from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 minsDisplacement of [125I-HEAT from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 mins
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmcl.2018.01.068
CHEMBL142635 40996 85 None 1 7 Human 8.9 pKi = 8.9 Binding
Displacement of [125I-HEAT from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 minsDisplacement of [125I-HEAT from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 mins
ChEMBL 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 10.1016/j.bmcl.2018.01.068
14468881 183062 0 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 347 10 1 3 4.5 c1ccc(OCCNCCOC(c2ccccc2)c2ccccc2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4462600 183062 0 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 347 10 1 3 4.5 c1ccc(OCCNCCOC(c2ccccc2)c2ccccc2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4595111 183062 0 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 347 10 1 3 4.5 c1ccc(OCCNCCOC(c2ccccc2)c2ccccc2)cc1 10.1016/j.ejmech.2019.05.024
52948823 23829 0 None 2 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 421 13 1 5 4.9 COc1cccc(OC)c1CCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1254659 23829 0 None 2 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 421 13 1 5 4.9 COc1cccc(OC)c1CCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
9822942 204716 0 None 35 4 Rat 8.9 pKi = 8.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 411 5 0 4 3.7 CCC1(C)CC(=O)N(CCN2CCN(c3cc(Cl)ccc3Cl)CC2)C(=O)C1 10.1021/jm030944+
CHEMBL57317 204716 0 None 35 4 Rat 8.9 pKi = 8.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 411 5 0 4 3.7 CCC1(C)CC(=O)N(CCN2CCN(c3cc(Cl)ccc3Cl)CC2)C(=O)C1 10.1021/jm030944+
9865801 101499 10 None -3 3 Human 8.9 pKi = 8.9 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 401 8 2 5 5.0 COc1c(C)c(C)c(O)c(C)c1CN(C)CCOc1cc(C)c(O)cc1C(C)C 10.1021/jm960697s
CHEMBL25300 101499 10 None -3 3 Human 8.9 pKi = 8.9 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 401 8 2 5 5.0 COc1c(C)c(C)c(O)c(C)c1CN(C)CCOc1cc(C)c(O)cc1C(C)C 10.1021/jm960697s
10071710 90907 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 436 5 1 7 2.7 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL220781 90907 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 436 5 1 7 2.7 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
10071710 90907 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 436 5 1 7 2.7 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL220781 90907 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 436 5 1 7 2.7 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
11638677 91364 0 None -50 6 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 340 5 0 5 2.8 COc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2016.06.052
CHEMBL2153423 91364 0 None -50 6 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 340 5 0 5 2.8 COc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2016.06.052
CHEMBL2220978 91364 0 None -50 6 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 340 5 0 5 2.8 COc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2016.06.052
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm011066n
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm011066n
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm011066n
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm021078o
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm021078o
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm021078o
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm9810654
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm9810654
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm9810654
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2010.05.023
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2010.05.023
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2010.05.023
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2019.02.056
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2019.02.056
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2019.02.056
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.bmcl.2010.01.030
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.bmcl.2010.01.030
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.bmcl.2010.01.030
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm800461k
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm800461k
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm800461k
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm200421e
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm200421e
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm200421e
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm301525w
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm301525w
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm301525w
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2016.09.050
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2016.09.050
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1016/j.ejmech.2016.09.050
9845181 214940 3 None 1 13 Human 8.9 pKi = 8.9 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 423 4 0 4 3.3 C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1021/jm0491391
CHEMBL98241 214940 3 None 1 13 Human 8.9 pKi = 8.9 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 423 4 0 4 3.3 C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1021/jm0491391
9845181 214940 3 None 1 13 Human 8.9 pKi = 8.9 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 423 4 0 4 3.3 C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1016/s0960-894x(01)00159-7
CHEMBL98241 214940 3 None 1 13 Human 8.9 pKi = 8.9 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 423 4 0 4 3.3 C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1016/s0960-894x(01)00159-7
10506361 164484 0 None -1 3 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 492 5 1 8 3.5 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc([N+](=O)[O-])cc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL40819 164484 0 None -1 3 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 492 5 1 8 3.5 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccc([N+](=O)[O-])cc54)c3=O)C[C@@H]21 10.1021/jm990567u
134147055 156353 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 354 7 0 4 3.8 COc1cccc(CCN2CCN(c3ccccc3OC(C)C)CC2)c1 10.1016/j.ejmech.2016.06.052
CHEMBL3946843 156353 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 354 7 0 4 3.8 COc1cccc(CCN2CCN(c3ccccc3OC(C)C)CC2)c1 10.1016/j.ejmech.2016.06.052
11800077 107288 0 None -2 3 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 481 4 1 6 4.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccc(Cl)c54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL291154 107288 0 None -2 3 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 481 4 1 6 4.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccc(Cl)c54)c3=O)C[C@@H]21 10.1021/jm990567u
11474937 203953 0 None -1 4 Rat 8.9 pKi = 8.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 395 5 0 4 3.4 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2C2CC2)CC1 10.1021/jm030944+
CHEMBL56804 203953 0 None -1 4 Rat 8.9 pKi = 8.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 395 5 0 4 3.4 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2C2CC2)CC1 10.1021/jm030944+
134139869 152978 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 384 8 0 5 3.9 COc1ccc(CCN2CCN(c3ccccc3OC(C)C)CC2)cc1OC 10.1016/j.ejmech.2016.06.052
CHEMBL3920110 152978 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 384 8 0 5 3.9 COc1ccc(CCN2CCN(c3ccccc3OC(C)C)CC2)cc1OC 10.1016/j.ejmech.2016.06.052
78815633 154294 2 None -1 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 340 7 0 4 3.5 CCOc1ccccc1N1CCN(CCc2ccc(OC)cc2)CC1 10.1016/j.ejmech.2016.06.052
CHEMBL3930616 154294 2 None -1 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 340 7 0 4 3.5 CCOc1ccccc1N1CCN(CCc2ccc(OC)cc2)CC1 10.1016/j.ejmech.2016.06.052
10678161 107592 0 None 1 3 Rat 8.9 pKi = 8.9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 455 5 1 8 2.2 COC(=O)c1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2s1 10.1021/jm000541z
CHEMBL293236 107592 0 None 1 3 Rat 8.9 pKi = 8.9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 455 5 1 8 2.2 COC(=O)c1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2s1 10.1021/jm000541z
11486511 108361 0 None -4 5 Rat 8.9 pKi = 8.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 403 4 0 4 3.6 O=C1CC2(CCCC2)CC(=O)N1CCN1CCCN(c2ccccc2Cl)CC1 10.1021/jm030944+
CHEMBL298595 108361 0 None -4 5 Rat 8.9 pKi = 8.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 403 4 0 4 3.6 O=C1CC2(CCCC2)CC(=O)N1CCN1CCCN(c2ccccc2Cl)CC1 10.1021/jm030944+
4209 9937 75 None -2 33 Rat 8.9 pKi = 8.9 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960510x
4893 9937 75 None -2 33 Rat 8.9 pKi = 8.9 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960510x
503 9937 75 None -2 33 Rat 8.9 pKi = 8.9 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960510x
5385 9937 75 None -2 33 Rat 8.9 pKi = 8.9 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960510x
CHEMBL2 9937 75 None -2 33 Rat 8.9 pKi = 8.9 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960510x
DB00457 9937 75 None -2 33 Rat 8.9 pKi = 8.9 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10.1021/jm960510x
46934793 23401 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 533 7 0 7 3.8 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CC4(CCCC4)CC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1241557 23401 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 533 7 0 7 3.8 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CC4(CCCC4)CC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
25181488 194161 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
CHEMBL493486 194161 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
44431553 94359 0 None 10 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 525 7 1 5 4.9 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233592 94359 0 None 10 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 525 7 1 5 4.9 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
10456471 107309 0 None -1 5 Rat 8.9 pKi = 8.9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 451 6 1 7 2.4 COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC 10.1021/jm000541z
CHEMBL291303 107309 0 None -1 5 Rat 8.9 pKi = 8.9 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 451 6 1 7 2.4 COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC 10.1021/jm000541z
9845181 214940 3 None -1 13 Rat 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 423 4 0 4 3.3 C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1021/jm020938y
CHEMBL98241 214940 3 None -1 13 Rat 8.9 pKi = 8.9 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 423 4 0 4 3.3 C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1021/jm020938y
49781236 24615 0 None -7 4 Rat 8.9 pKi = 8.9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 390 2 0 5 4.1 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4cnn(C)c4)cc32)CC1 10.1021/jm100652h
CHEMBL1258987 24615 0 None -7 4 Rat 8.9 pKi = 8.9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 390 2 0 5 4.1 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4cnn(C)c4)cc32)CC1 10.1021/jm100652h
10648335 106938 0 None -1 3 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 478 5 1 8 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5c(OC)ccnc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL287928 106938 0 None -1 3 Rat 8.9 pKi = 8.9 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 478 5 1 8 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5c(OC)ccnc54)c3=O)C[C@@H]21 10.1021/jm990567u
9822705 107464 0 None 11 4 Rat 8.9 pKi = 8.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 407 4 0 3 4.4 O=C1CC2(C=CN1CCN1CCN(c3cc(Cl)ccc3Cl)CC1)CCCC2 10.1021/jm030944+
CHEMBL292366 107464 0 None 11 4 Rat 8.9 pKi = 8.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 407 4 0 3 4.4 O=C1CC2(C=CN1CCN1CCN(c3cc(Cl)ccc3Cl)CC1)CCCC2 10.1021/jm030944+
2419 7482 28 None -1 11 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm991065j
9 7482 28 None -1 11 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm991065j
CHEMBL13647 7482 28 None -1 11 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm991065j
10606661 107716 0 None -1 3 Rat 8.8 pKi = 8.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 441 5 1 7 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)c(OC)sc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL294027 107716 0 None -1 3 Rat 8.8 pKi = 8.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 441 5 1 7 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)c(OC)sc4c3=O)C[C@@H]21 10.1021/jm000541z
46934637 23443 0 None 3 4 Human 8.8 pKi = 8.8 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 465 7 0 6 3.1 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3CCCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242542 23443 0 None 3 4 Human 8.8 pKi = 8.8 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 465 7 0 6 3.1 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3CCCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
44431611 94260 0 None 7 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Cl)cc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233410 94260 0 None 7 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Cl)cc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
10624165 107338 0 None -3 3 Rat 8.8 pKi = 8.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 469 6 1 7 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C(C)C)c(OC)sc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL291528 107338 0 None -3 3 Rat 8.8 pKi = 8.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 469 6 1 7 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C(C)C)c(OC)sc4c3=O)C[C@@H]21 10.1021/jm000541z
9845172 175888 0 None 25 4 Rat 8.8 pKi = 8.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 422 4 0 3 4.9 O=C1CC2(CCCC2)CC(=O)N1CCN1CCC(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL440118 175888 0 None 25 4 Rat 8.8 pKi = 8.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 422 4 0 3 4.9 O=C1CC2(CCCC2)CC(=O)N1CCN1CCC(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
145946536 174363 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4213029 174363 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4300721 174363 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
16041264 102218 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL257077 102218 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
44431192 99334 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 448 5 0 6 3.6 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccnc4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
CHEMBL243228 99334 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 448 5 0 6 3.6 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccnc4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
49782791 24682 0 None -3 6 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 381 3 1 4 3.3 CC(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
CHEMBL1259173 24682 0 None -3 6 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 381 3 1 4 3.3 CC(=O)NCc1ccc2c(c1)[C@H](N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
10095044 109081 0 None -1 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 445 6 0 8 3.2 COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c3c(C)onc3c2=O)CC1 10.1021/jm0307741
CHEMBL303464 109081 0 None -1 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 445 6 0 8 3.2 COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c3c(C)onc3c2=O)CC1 10.1021/jm0307741
148842 10718 27 None -8 5 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 511 8 1 6 4.7 COc1ccccc1N1CCN(CC1)CCCNC(=O)c1cccc2c1oc(c1ccccc1)c(c2=O)C 10.1021/jm030825u
496 10718 27 None -8 5 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 511 8 1 6 4.7 COc1ccccc1N1CCN(CC1)CCCNC(=O)c1cccc2c1oc(c1ccccc1)c(c2=O)C 10.1021/jm030825u
CHEMBL278865 10718 27 None -8 5 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 511 8 1 6 4.7 COc1ccccc1N1CCN(CC1)CCCNC(=O)c1cccc2c1oc(c1ccccc1)c(c2=O)C 10.1021/jm030825u
44428849 150407 0 None 2 3 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 436 4 2 7 2.8 COc1cc2nc(N3CCN(C(=O)c4ccc[nH]4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL389978 150407 0 None 2 3 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 436 4 2 7 2.8 COc1cc2nc(N3CCN(C(=O)c4ccc[nH]4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
71659980 152671 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 354 6 0 5 3.2 CCOc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2016.06.052
CHEMBL3917716 152671 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 354 6 0 5 3.2 CCOc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2016.06.052
44420408 148536 0 None 5 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 453 5 2 6 2.7 COc1ccc(Cl)cc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL386005 148536 0 None 5 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 453 5 2 6 2.7 COc1ccc(Cl)cc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
76330229 113012 0 None -5 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL2261605 113012 0 None -5 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL3138857 113012 0 None -5 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
44428845 149140 0 None -5 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL388884 149140 0 None -5 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 515 4 1 8 3.9 COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
10767981 203041 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 509 11 1 9 3.5 COc1cc2nc(N(C)CCCCCCN(C)C(=O)C3COc4ccccc4O3)nc(N)c2cc1OC 10.1021/jm8016046
CHEMBL561851 203041 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 509 11 1 9 3.5 COc1cc2nc(N(C)CCCCCCN(C)C(=O)C3COc4ccccc4O3)nc(N)c2cc1OC 10.1021/jm8016046
CHEMBL4753450 220845 0 None - 1 Human 8.8 pKi = 8.8 Binding
Affinity Biochemical interaction (Binding assay) EUB0000300bCl ADRA1DAffinity Biochemical interaction (Binding assay) EUB0000300bCl ADRA1D
ChEMBL None None None C[C@@H](c1cccc(CN)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.6019/CHEMBL5210307
CHEMBL4802854 220845 0 None - 1 Human 8.8 pKi = 8.8 Binding
Affinity Biochemical interaction (Binding assay) EUB0000300bCl ADRA1DAffinity Biochemical interaction (Binding assay) EUB0000300bCl ADRA1D
ChEMBL None None None C[C@@H](c1cccc(CN)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.6019/CHEMBL5210307
102 10899 48 None -363 49 Human 8.8 pKi = 8.8 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
3659 10899 48 None -363 49 Human 8.8 pKi = 8.8 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
8969 10899 48 None -363 49 Human 8.8 pKi = 8.8 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
CHEMBL15245 10899 48 None -363 49 Human 8.8 pKi = 8.8 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
DB01392 10899 48 None -363 49 Human 8.8 pKi = 8.8 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
2419 7482 28 None -1 11 Human 8.8 pKi = 8.8 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm0491391
9 7482 28 None -1 11 Human 8.8 pKi = 8.8 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm0491391
CHEMBL13647 7482 28 None -1 11 Human 8.8 pKi = 8.8 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm0491391
11857864 92459 0 None 2 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 534 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4cc(F)ccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL228659 92459 0 None 2 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 534 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4cc(F)ccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
11857792 176148 0 None 3 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 560 8 1 5 5.8 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1 10.1016/j.bmcl.2007.04.098
CHEMBL442059 176148 0 None 3 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 560 8 1 5 5.8 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1 10.1016/j.bmcl.2007.04.098
11384983 204081 0 None -1 4 Rat 8.8 pKi = 8.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 433 4 0 4 3.3 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2Br)CC1 10.1021/jm030944+
CHEMBL56869 204081 0 None -1 4 Rat 8.8 pKi = 8.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 433 4 0 4 3.3 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2Br)CC1 10.1021/jm030944+
2419 7482 28 None -1 11 Human 8.8 pKi = 8.8 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor (n >= 2)Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor (n >= 2)
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm980053f
9 7482 28 None -1 11 Human 8.8 pKi = 8.8 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor (n >= 2)Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor (n >= 2)
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm980053f
CHEMBL13647 7482 28 None -1 11 Human 8.8 pKi = 8.8 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor (n >= 2)Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor (n >= 2)
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm980053f
44470113 146656 5 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 300 3 2 4 2.2 C[C@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
CHEMBL3799292 146656 5 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 300 3 2 4 2.2 C[C@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
16041092 102155 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL256804 102155 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
126225 101751 5 None 1 7 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 263 1 0 2 4.2 C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm0307741
CHEMBL25467 101751 5 None 1 7 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 263 1 0 2 4.2 C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm0307741
9845181 214940 3 None 1 13 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 423 4 0 4 3.3 C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1021/jm0307741
CHEMBL98241 214940 3 None 1 13 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 423 4 0 4 3.3 C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O 10.1021/jm0307741
126225 101751 5 None 1 7 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 263 1 0 2 4.2 C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm00019a001
CHEMBL25467 101751 5 None 1 7 Human 8.8 pKi = 8.8 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 263 1 0 2 4.2 C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm00019a001
90645601 119211 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 564 10 2 9 3.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCN(C)C)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298019 119211 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 564 10 2 9 3.0 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCN(C)C)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
3157 8252 71 None -1 12 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
7170 8252 71 None -1 12 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
954 8252 71 None -1 12 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
CHEMBL707 8252 71 None -1 12 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
DB00590 8252 71 None -1 12 Human 8.8 pKi = 8.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 nan
10643502 107726 0 None -1 3 Rat 8.8 pKi = 8.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 380 4 2 5 1.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4[nH]ccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL294098 107726 0 None -1 3 Rat 8.8 pKi = 8.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 380 4 2 5 1.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4[nH]ccc4c3=O)C[C@@H]21 10.1021/jm000541z
11857638 150588 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 516 9 1 6 5.0 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL390129 150588 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 516 9 1 6 5.0 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
11487449 202268 0 None 1 4 Rat 8.8 pKi = 8.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 437 5 0 4 4.2 O=C1CC2(CCCC2)CC(=O)N1CCCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL55319 202268 0 None 1 4 Rat 8.8 pKi = 8.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 437 5 0 4 4.2 O=C1CC2(CCCC2)CC(=O)N1CCCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
155532148 178480 0 None 1 7 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 444 6 0 5 4.2 COc1ccccc1N1CCN(CC2COCC(c3ccccc3)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2019.02.056
CHEMBL4466677 178480 0 None 1 7 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 444 6 0 5 4.2 COc1ccccc1N1CCN(CC2COCC(c3ccccc3)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2019.02.056
134149596 155244 0 None -4 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 368 6 0 5 3.6 CC(C)Oc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2016.06.052
CHEMBL3938038 155244 0 None -4 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 368 6 0 5 3.6 CC(C)Oc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 10.1016/j.ejmech.2016.06.052
10691912 174799 0 None -1 3 Rat 8.8 pKi = 8.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 392 4 1 6 1.8 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cnccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL432147 174799 0 None -1 3 Rat 8.8 pKi = 8.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 392 4 1 6 1.8 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cnccc4c3=O)C[C@@H]21 10.1021/jm000541z
9931327 76585 1 None 190 5 Human 8.7 pKi = 8.7 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 409 4 0 4 2.9 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)c(F)cc2F)CC1 10.1021/jm0491391
CHEMBL193620 76585 1 None 190 5 Human 8.7 pKi = 8.7 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 409 4 0 4 2.9 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)c(F)cc2F)CC1 10.1021/jm0491391
49781235 24702 0 None -7 4 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 390 2 0 5 4.1 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccn(C)n4)cc32)CC1 10.1021/jm100652h
CHEMBL1259232 24702 0 None -7 4 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 390 2 0 5 4.1 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccn(C)n4)cc32)CC1 10.1021/jm100652h
71817386 109363 0 None -3 7 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 355 7 1 6 3.3 COc1ccc2ccoc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL2419769 109363 0 None -3 7 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 355 7 1 6 3.3 COc1ccc2ccoc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL3040851 109363 0 None -3 7 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 355 7 1 6 3.3 COc1ccc2ccoc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
2726 7706 68 None 1 72 Human 8.7 pKi = 8.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
621 7706 68 None 1 72 Human 8.7 pKi = 8.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
83 7706 68 None 1 72 Human 8.7 pKi = 8.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
CHEMBL71 7706 68 None 1 72 Human 8.7 pKi = 8.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
DB00477 7706 68 None 1 72 Human 8.7 pKi = 8.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
10620533 208643 0 None -1 3 Rat 8.7 pKi = 8.7 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 392 4 1 6 1.8 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ncccc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL60722 208643 0 None -1 3 Rat 8.7 pKi = 8.7 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 392 4 1 6 1.8 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ncccc4c3=O)C[C@@H]21 10.1021/jm000541z
4151 10379 89 None -33 3 Human 8.7 pKi = 8.7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/jm960697s
493 10379 89 None -33 3 Human 8.7 pKi = 8.7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/jm960697s
5312125 10379 89 None -33 3 Human 8.7 pKi = 8.7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/jm960697s
CHEMBL24778 10379 89 None -33 3 Human 8.7 pKi = 8.7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/jm960697s
DB06207 10379 89 None -33 3 Human 8.7 pKi = 8.7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 10.1021/jm960697s
11705133 79105 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 453 14 1 7 4.3 COc1ccccc1COc1ccccc1OCCNCCOc1c(OC)cccc1OC 10.1021/jm0580398
CHEMBL198431 79105 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cellsDisplacement of [3H]prazosin from cloned human ADRA1D expressed in CHO cells
ChEMBL 453 14 1 7 4.3 COc1ccccc1COc1ccccc1OCCNCCOc1c(OC)cccc1OC 10.1021/jm0580398
44298664 204065 0 None -31 3 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 462 7 1 6 2.8 O=c1[nH]c2ccccc2c(=O)n1CCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
CHEMBL56863 204065 0 None -31 3 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 462 7 1 6 2.8 O=c1[nH]c2ccccc2c(=O)n1CCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
10674055 210995 0 None -50 3 Human 8.0 pKi = 8 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 542 9 2 7 3.9 CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(O)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL70892 210995 0 None -50 3 Human 8.0 pKi = 8 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 542 9 2 7 3.9 CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(O)cc2)C3=O)CC1 10.1021/jm9905918
489 6933 28 None -34 12 Human 8.0 pKi = 8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm960697s
5640 6933 28 None -34 12 Human 8.0 pKi = 8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm960697s
CHEMBL420060 6933 28 None -34 12 Human 8.0 pKi = 8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm960697s
25025052 146559 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 286 3 2 4 1.6 N#Cc1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3798655 146559 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 286 3 2 4 1.6 N#Cc1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
155533100 183123 0 None -1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 377 11 1 4 4.5 COc1ccccc1OCCNCCOC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.05.024
CHEMBL4468507 183123 0 None -1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 377 11 1 4 4.5 COc1ccccc1OCCNCCOC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.05.024
CHEMBL4595564 183123 0 None -1 4 Human 8.0 pKi = 8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 377 11 1 4 4.5 COc1ccccc1OCCNCCOC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.05.024
44298770 108388 0 None -10 3 Human 8.0 pKi = 8 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 464 7 1 6 2.5 O=c1[nH]cc(Cl)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
CHEMBL298838 108388 0 None -10 3 Human 8.0 pKi = 8 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 464 7 1 6 2.5 O=c1[nH]cc(Cl)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
9929936 174691 0 None 9 5 Rat 8.0 pKi = 8.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 383 4 0 4 3.1 Cc1ccc(C)c(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c1 10.1021/jm030944+
CHEMBL431354 174691 0 None 9 5 Rat 8.0 pKi = 8.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 383 4 0 4 3.1 Cc1ccc(C)c(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c1 10.1021/jm030944+
6603808 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL214986 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL36622 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL3740374 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
6603808 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL214986 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL36622 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL3740374 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1016/j.ejmech.2012.09.049
6603808 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm301525w
CHEMBL214986 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm301525w
CHEMBL36622 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm301525w
CHEMBL3740374 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm301525w
6603808 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1039/C4MD00484A
CHEMBL214986 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1039/C4MD00484A
CHEMBL36622 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1039/C4MD00484A
CHEMBL3740374 134300 3 None 1 9 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 345 8 1 6 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 10.1039/C4MD00484A
118716714 121786 0 None -2 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 501 6 0 7 2.7 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(C)cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342867 121786 0 None -2 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 501 6 0 7 2.7 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(C)cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
118716707 121779 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 519 5 0 6 3.9 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccc(C(F)(F)F)cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342860 121779 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 519 5 0 6 3.9 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccc(C(F)(F)F)cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
487 10406 21 None -426 12 Human 7.0 pKi = 7 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
60602 10406 21 None -426 12 Human 7.0 pKi = 7 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
CHEMBL405355 10406 21 None -426 12 Human 7.0 pKi = 7 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
DB09239 10406 21 None -426 12 Human 7.0 pKi = 7 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
463 8187 22 None -50 13 Human 7.0 pKi = 7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
6918097 8187 22 None -50 13 Human 7.0 pKi = 7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
837 8187 22 None -50 13 Human 7.0 pKi = 7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
CHEMBL2051956 8187 22 None -50 13 Human 7.0 pKi = 7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
DB14068 8187 22 None -50 13 Human 7.0 pKi = 7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
497 10138 8 None -61 3 Human 7.0 pKi = 7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 444 7 1 6 2.1 Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C 10.1021/jm960697s
9872515 10138 8 None -61 3 Human 7.0 pKi = 7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 444 7 1 6 2.1 Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C 10.1021/jm960697s
CHEMBL24777 10138 8 None -61 3 Human 7.0 pKi = 7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 444 7 1 6 2.1 Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C 10.1021/jm960697s
134138438 154121 0 None -33 4 Human 7.0 pKi = 7 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 378 4 0 5 4.3 COc1ccccc1N1CCN(CC2CSC3(CCCCC3)S2)CC1 10.1016/j.ejmech.2016.09.050
CHEMBL3929328 154121 0 None -33 4 Human 7.0 pKi = 7 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 378 4 0 5 4.3 COc1ccccc1N1CCN(CC2CSC3(CCCCC3)S2)CC1 10.1016/j.ejmech.2016.09.050
10393665 40696 0 None -151 3 Human 7.0 pKi = 7 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 593 9 2 9 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
CHEMBL142383 40696 0 None -151 3 Human 7.0 pKi = 7 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 593 9 2 9 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
11338630 16429 0 None 2 3 Rat 7.0 pKi = 7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 403 4 2 3 4.8 O=S(=O)(Nc1cccc2c1CCCC2c1c[nH]cn1)c1ccc2ccccc2c1 10.1021/jm030551a
CHEMBL112814 16429 0 None 2 3 Rat 7.0 pKi = 7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 403 4 2 3 4.8 O=S(=O)(Nc1cccc2c1CCCC2c1c[nH]cn1)c1ccc2ccccc2c1 10.1021/jm030551a
44298762 107405 0 None -15 3 Human 7.0 pKi = 7 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 473 8 1 7 1.9 CN(C)c1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
CHEMBL291951 107405 0 None -15 3 Human 7.0 pKi = 7 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 473 8 1 7 1.9 CN(C)c1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
9903797 16211 5 None -18 4 Rat 6.0 pKi = 6 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 279 5 2 3 2.1 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1C 10.1007/s00044-004-0020-z
CHEMBL111734 16211 5 None -18 4 Rat 6.0 pKi = 6 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 279 5 2 3 2.1 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1C 10.1007/s00044-004-0020-z
153287553 177883 0 None -158 6 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Prazosin from human recombinant adrenergic Alpha1D receptor expressed in cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Prazosin from human recombinant adrenergic Alpha1D receptor expressed in cells after 90 mins by microbeta scintillation counting method
ChEMBL 264 1 1 2 3.7 C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
CHEMBL4457754 177883 0 None -158 6 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Prazosin from human recombinant adrenergic Alpha1D receptor expressed in cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Prazosin from human recombinant adrenergic Alpha1D receptor expressed in cells after 90 mins by microbeta scintillation counting method
ChEMBL 264 1 1 2 3.7 C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2 10.1021/acsmedchemlett.9b00225
10236758 122550 5 None -1023 13 Human 6.0 pKi = 6 Binding
Displacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 328 7 0 2 4.3 CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 10.1021/acs.jmedchem.8b00265
CHEMBL3354065 122550 5 None -1023 13 Human 6.0 pKi = 6 Binding
Displacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 328 7 0 2 4.3 CCCCC1CCN(CCCN2C(=O)CCc3ccccc32)CC1 10.1021/acs.jmedchem.8b00265
10703393 127035 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 204 2 1 2 2.9 Cc1ccsc1C1(c2c[nH]cn2)CC1 10.1021/jm0003891
CHEMBL1744265 127035 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 204 2 1 2 2.9 Cc1ccsc1C1(c2c[nH]cn2)CC1 10.1021/jm0003891
CHEMBL352374 127035 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 204 2 1 2 2.9 Cc1ccsc1C1(c2c[nH]cn2)CC1 10.1021/jm0003891
11736917 16049 2 None -1 2 Rat 6.0 pKi = 6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 254 4 2 3 1.5 CCS(=O)(=O)Nc1cccc(C2CCNC2)c1 10.1021/jm030551a
CHEMBL110859 16049 2 None -1 2 Rat 6.0 pKi = 6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 254 4 2 3 1.5 CCS(=O)(=O)Nc1cccc(C2CCNC2)c1 10.1021/jm030551a
9903797 16211 5 None -18 4 Rat 6.0 pKi = 6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 279 5 2 3 2.1 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1C 10.1021/jm030551a
CHEMBL111734 16211 5 None -18 4 Rat 6.0 pKi = 6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 279 5 2 3 2.1 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1C 10.1021/jm030551a
44267912 23655 0 None -102 3 Human 5.0 pKi = 5 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 388 8 1 5 1.3 COc1ccccc1N1CCN(CCCNC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL12501 23655 0 None -102 3 Human 5.0 pKi = 5 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 388 8 1 5 1.3 COc1ccccc1N1CCN(CCCNC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
237 211644 48 None -1 13 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL546257 211644 48 None -1 13 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL554190 211644 48 None -1 13 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
CHEMBL7568 211644 48 None -1 13 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 nan
19085836 212444 0 None -6 3 Human 6.0 pKi = 6.0 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 469 6 0 7 3.2 Cc1cccc2oc(=O)n(C3CCN(CCCCN4C(=O)c5ccccc5S4(=O)=O)CC3)c12 10.1016/s0960-894x(98)00446-6
CHEMBL82056 212444 0 None -6 3 Human 6.0 pKi = 6.0 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 469 6 0 7 3.2 Cc1cccc2oc(=O)n(C3CCN(CCCCN4C(=O)c5ccccc5S4(=O)=O)CC3)c12 10.1016/s0960-894x(98)00446-6
145951457 169703 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 303 3 2 7 1.2 COc1cc2nc(N3CCC[C@@H](N)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
CHEMBL4174168 169703 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 303 3 2 7 1.2 COc1cc2nc(N3CCC[C@@H](N)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
44568917 194134 0 None -13 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNC[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1 10.1021/jm800461k
CHEMBL493283 194134 0 None -13 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNC[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1 10.1021/jm800461k
6604803 123296 2 None -457 4 Rat 6.0 pKi = 6.0 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1 10.1021/jm960354u
CHEMBL336161 123296 2 None -457 4 Rat 6.0 pKi = 6.0 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1 10.1021/jm960354u
145962817 168298 0 None -34 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 385 3 1 7 2.2 COc1cc2nc(N3CCN(C(C)=O)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4128311 168298 0 None -34 6 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 385 3 1 7 2.2 COc1cc2nc(N3CCN(C(C)=O)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
9809007 179343 8 None -407 6 Human 6.0 pKi = 6.0 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
CHEMBL448620 179343 8 None -407 6 Human 6.0 pKi = 6.0 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
9796525 16179 0 None -7 3 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 3 1 4 2.3 Cn1cnc(C2CCCc3c(NS(C)(=O)=O)cccc32)c1 10.1021/jm030551a
CHEMBL111584 16179 0 None -7 3 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 3 1 4 2.3 Cn1cnc(C2CCCc3c(NS(C)(=O)=O)cccc32)c1 10.1021/jm030551a
10047430 111538 0 None -117 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 414 7 0 6 3.4 CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3CCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00436-5
CHEMBL310768 111538 0 None -117 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 414 7 0 6 3.4 CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3CCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00436-5
11098175 210949 0 None 1 5 Human 7.0 pKi = 7.0 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 251 5 2 5 1.8 COc1ccc(SC)c(NCC2=NCCN2)c1 10.1021/jm000542r
CHEMBL70691 210949 0 None 1 5 Human 7.0 pKi = 7.0 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 251 5 2 5 1.8 COc1ccc(SC)c(NCC2=NCCN2)c1 10.1021/jm000542r
76326541 92116 0 None -60 4 Rat 6.0 pKi = 6.0 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCC[C@H]2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL2261355 92116 0 None -60 4 Rat 6.0 pKi = 6.0 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCC[C@H]2c1c[nH]cn1 10.1007/s00044-004-0020-z
9926529 16161 2 None -19 5 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL111496 16161 2 None -19 5 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
44267884 22339 0 None -2 3 Human 7.0 pKi = 7.0 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 403 8 0 6 2.2 CC(C)Oc1ccccc1N1CCN(CCOC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL12202 22339 0 None -2 3 Human 7.0 pKi = 7.0 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 403 8 0 6 2.2 CC(C)Oc1ccccc1N1CCN(CCOC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
44431599 94795 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 505 7 1 5 4.8 Cc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1Cl 10.1016/j.bmcl.2007.04.008
CHEMBL234423 94795 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 505 7 1 5 4.8 Cc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1Cl 10.1016/j.bmcl.2007.04.008
17753379 94838 0 None -2 4 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 521 8 1 6 4.5 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234607 94838 0 None -2 4 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 521 8 1 6 4.5 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
2142 9870 58 None -5 37 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
4920903 9870 58 None -5 37 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
502 9870 58 None -5 37 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
5775 9870 58 None -5 37 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
CHEMBL597 9870 58 None -5 37 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
DB00692 9870 58 None -5 37 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 nan
59151671 146621 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 320 3 2 4 2.3 N#Cc1ccc(Cn2cc(Cl)cc(C(N)=O)c2=N)cc1Cl 10.1021/acs.jmedchem.5b01528
CHEMBL3799115 146621 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 320 3 2 4 2.3 N#Cc1ccc(Cn2cc(Cl)cc(C(N)=O)c2=N)cc1Cl 10.1021/acs.jmedchem.5b01528
44300170 175039 0 None -4 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.5 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL433832 175039 0 None -4 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.5 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
11108001 17644 2 None 3 6 Human 8.0 pKi = 8.0 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL117248 17644 2 None 3 6 Human 8.0 pKi = 8.0 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL540542 17644 2 None 3 6 Human 8.0 pKi = 8.0 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
9976756 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm021078o
CHEMBL1083181 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm021078o
CHEMBL37883 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm021078o
9976756 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL1083181 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL37883 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
9976756 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.bmcl.2010.01.030
CHEMBL1083181 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.bmcl.2010.01.030
CHEMBL37883 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.bmcl.2010.01.030
9976756 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm200421e
CHEMBL1083181 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm200421e
CHEMBL37883 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm200421e
9976756 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL1083181 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL37883 13379 0 None -3 5 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
44289525 172774 0 None -12 9 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 435 9 1 6 4.6 COc1cccc(OC)c1OCCNCC1Oc2ccccc2OC1c1ccc(C)cc1 10.1021/jm960069a
CHEMBL42539 172774 0 None -12 9 Rat 7.9 pKi = 7.9 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 435 9 1 6 4.6 COc1cccc(OC)c1OCCNCC1Oc2ccccc2OC1c1ccc(C)cc1 10.1021/jm960069a
10916771 111991 0 None -53 4 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 419 7 1 7 2.7 COc1ccccc1N1CCN(CCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL311479 111991 0 None -53 4 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 419 7 1 7 2.7 COc1ccccc1N1CCN(CCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
11144555 212017 0 None -4 4 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 433 8 1 7 3.1 COc1ccccc1N1CCN(CCCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL78785 212017 0 None -4 4 Human 7.9 pKi = 7.9 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 433 8 1 7 3.1 COc1ccccc1N1CCN(CCCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
10743042 194931 0 None -2 4 Human 7.9 pKi = 7.9 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 471 5 1 8 3.1 Cn1nc(Cl)c2cn3nc(NCCN4CCN(c5ccccc5Cl)CC4)ccc3c2c1=O 10.1021/jm981006q
CHEMBL49851 194931 0 None -2 4 Human 7.9 pKi = 7.9 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 471 5 1 8 3.1 Cn1nc(Cl)c2cn3nc(NCCN4CCN(c5ccccc5Cl)CC4)ccc3c2c1=O 10.1021/jm981006q
1443 8809 34 None -16 11 Human 7.0 pKi = 7.0 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
33625 8809 34 None -16 11 Human 7.0 pKi = 7.0 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
501 8809 34 None -16 11 Human 7.0 pKi = 7.0 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
CHEMBL279516 8809 34 None -16 11 Human 7.0 pKi = 7.0 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
DB08950 8809 34 None -16 11 Human 7.0 pKi = 7.0 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
10841070 44453 0 None -380 4 Human 7.0 pKi = 7.0 Binding
Binding affinity against isolated human aorta using [3H]- prazosin.Binding affinity against isolated human aorta using [3H]- prazosin.
ChEMBL 585 10 0 5 7.4 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL145746 44453 0 None -380 4 Human 7.0 pKi = 7.0 Binding
Binding affinity against isolated human aorta using [3H]- prazosin.Binding affinity against isolated human aorta using [3H]- prazosin.
ChEMBL 585 10 0 5 7.4 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10817365 43487 0 None -1819 3 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 599 9 2 7 3.9 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL144933 43487 0 None -1819 3 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 599 9 2 7 3.9 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)C(=O)N1 10.1021/jm990201h
44299764 107505 0 None 4 2 Rat 7.0 pKi = 7.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 426 8 0 4 4.4 CN(CCCOc1cc(Cl)ccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
CHEMBL292672 107505 0 None 4 2 Rat 7.0 pKi = 7.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 426 8 0 4 4.4 CN(CCCOc1cc(Cl)ccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
11453476 174692 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 439 8 0 4 4.5 CN(CCCN(C)c1cc(Cl)ccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
CHEMBL431357 174692 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 439 8 0 4 4.5 CN(CCCN(C)c1cc(Cl)ccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
10507411 40956 0 None -1000 3 Human 6.0 pKi = 6.0 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 577 9 0 5 7.3 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3C(F)(F)F)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL142606 40956 0 None -1000 3 Human 6.0 pKi = 6.0 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 577 9 0 5 7.3 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3C(F)(F)F)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10506484 43572 0 None -1096 3 Human 6.0 pKi = 6.0 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 534 9 0 6 5.9 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C#N)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL145001 43572 0 None -1096 3 Human 6.0 pKi = 6.0 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 534 9 0 6 5.9 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C#N)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10578548 43786 0 None -912 3 Human 6.0 pKi = 6.0 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 548 9 0 6 6.2 COC(=O)C1=C(C)N=C(C)N(CCC[C@H](C)CN2CCC(C#N)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL145178 43786 0 None -912 3 Human 6.0 pKi = 6.0 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 548 9 0 6 6.2 COC(=O)C1=C(C)N=C(C)N(CCC[C@H](C)CN2CCC(C#N)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
118718431 122132 0 None -11 2 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 504 8 0 6 3.9 CCOC(=O)[C@H]1CN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC[C@H]1c1ccccc1 10.1016/s0960-894x(98)00451-x
CHEMBL3349545 122132 0 None -11 2 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 504 8 0 6 3.9 CCOC(=O)[C@H]1CN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC[C@H]1c1ccccc1 10.1016/s0960-894x(98)00451-x
44295044 108357 0 None -190 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 535 6 2 6 3.5 N#CC1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL298579 108357 0 None -190 3 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 535 6 2 6 3.5 N#CC1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
10841851 41089 0 None -851 3 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 569 9 4 6 2.2 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 10.1021/jm990202+
CHEMBL142718 41089 0 None -851 3 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 569 9 4 6 2.2 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 10.1021/jm990202+
44288815 108231 0 None -147 3 Human 6.0 pKi = 6.0 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 431 8 1 3 5.1 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3C)CC2)C(C)C)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL297667 108231 0 None -147 3 Human 6.0 pKi = 6.0 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 431 8 1 3 5.1 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3C)CC2)C(C)C)cc1 10.1016/s0960-894x(00)00307-3
9982585 108293 0 None -851 3 Human 6.0 pKi = 6.0 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 479 8 1 3 5.8 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3C)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL298058 108293 0 None -851 3 Human 6.0 pKi = 6.0 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 479 8 1 3 5.8 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3C)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL41844 170011 0 None -309 4 Human 6.0 pKi = 6.0 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 590 10 2 9 4.6 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)N=C(C)/C(=C(/O)OC)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(00)00307-3
44460522 212166 0 None -3 2 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 460 7 0 7 3.6 CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3C(=O)c4ccccc4C3=O)co2)CC1 10.1016/s0960-894x(02)00436-5
CHEMBL79990 212166 0 None -3 2 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 460 7 0 7 3.6 CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3C(=O)c4ccccc4C3=O)co2)CC1 10.1016/s0960-894x(02)00436-5
44431557 153450 0 None -1 4 Human 7.0 pKi = 7.0 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 541 8 1 6 4.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL392377 153450 0 None -1 4 Human 7.0 pKi = 7.0 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 541 8 1 6 4.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
9850782 110376 0 None -72 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 560 9 2 7 3.3 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(F)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL308671 110376 0 None -72 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 560 9 2 7 3.3 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(F)cc2)C3=O)CC1 10.1021/jm9905918
127036953 144293 0 None -112 22 Human 6.0 pKi = 6.0 Binding
Binding affinity to alpha-1D adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-1D adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 318 7 1 1 4.1 C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3754166 144293 0 None -112 22 Human 6.0 pKi = 6.0 Binding
Binding affinity to alpha-1D adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-1D adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 318 7 1 1 4.1 C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12 10.1016/j.bmcl.2015.12.053
10651080 112719 0 None -131 6 Human 5.9 pKi = 5.9 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 592 9 3 6 4.7 CC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL312871 112719 0 None -131 6 Human 5.9 pKi = 5.9 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 592 9 3 6 4.7 CC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
10531532 213873 0 None -131 6 Human 5.9 pKi = 5.9 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 594 9 2 7 6.0 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL91956 213873 0 None -131 6 Human 5.9 pKi = 5.9 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 594 9 2 7 6.0 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
11164948 44517 0 None -3 3 Human 5.9 pKi = 5.9 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 382 5 2 6 3.1 COc1cc2nc3c(c(O)c2cc1OC)CCC(CNC(=O)c1ccco1)C3 10.1021/jm030952q
CHEMBL145793 44517 0 None -3 3 Human 5.9 pKi = 5.9 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 382 5 2 6 3.1 COc1cc2nc3c(c(O)c2cc1OC)CCC(CNC(=O)c1ccco1)C3 10.1021/jm030952q
9814617 16106 0 None -2 2 Rat 5.9 pKi = 5.9 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 293 3 2 4 1.7 CS(=O)(=O)Nc1cccc2c1OCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL111151 16106 0 None -2 2 Rat 5.9 pKi = 5.9 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 293 3 2 4 1.7 CS(=O)(=O)Nc1cccc2c1OCCC2c1c[nH]cn1 10.1021/jm030551a
9847419 214973 0 None -14 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 467 5 2 5 3.9 Cc1[nH]c2ccccc2c1CCN1CCC2(CC1)CC(=O)c1ccc(NS(C)(=O)=O)cc1O2 10.1016/s0960-894x(98)00732-x
CHEMBL98430 214973 0 None -14 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 467 5 2 5 3.9 Cc1[nH]c2ccccc2c1CCN1CCC2(CC1)CC(=O)c1ccc(NS(C)(=O)=O)cc1O2 10.1016/s0960-894x(98)00732-x
10020855 85598 0 None -588 6 Human 6.9 pKi = 6.9 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 351 4 0 4 3.9 COc1cccc(C2CCC(N3CCN(c4ccccn4)CC3)CC2)c1 10.1021/jm010866v
CHEMBL2112778 85598 0 None -588 6 Human 6.9 pKi = 6.9 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 351 4 0 4 3.9 COc1cccc(C2CCC(N3CCN(c4ccccn4)CC3)CC2)c1 10.1021/jm010866v
17753379 94578 0 None 1 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 521 8 1 6 4.5 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233816 94578 0 None 1 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 521 8 1 6 4.5 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
44431616 94852 0 None -3 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 471 8 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234650 94852 0 None -3 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 471 8 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
11857863 92453 0 None 1 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 534 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccc(F)cc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL228608 92453 0 None 1 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 534 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccc(F)cc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
145947141 174405 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 371 5 1 4 3.0 O=S1(=O)CCC(NCCOc2cc(F)ccc2F)c2cc(F)ccc21 10.1016/j.ejmech.2017.07.071
CHEMBL4218841 174405 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 371 5 1 4 3.0 O=S1(=O)CCC(NCCOc2cc(F)ccc2F)c2cc(F)ccc21 10.1016/j.ejmech.2017.07.071
CHEMBL4301452 174405 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 371 5 1 4 3.0 O=S1(=O)CCC(NCCOc2cc(F)ccc2F)c2cc(F)ccc21 10.1016/j.ejmech.2017.07.071
18738387 170277 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 399 6 0 5 3.6 COc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)s2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL420184 170277 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 399 6 0 5 3.6 COc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)s2)CC1 10.1016/s0960-894x(02)00347-5
10699164 43802 0 None -151 3 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 552 7 2 7 3.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C#N)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145190 43802 0 None -151 3 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 552 7 2 7 3.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C#N)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
10776978 66241 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 248 4 1 2 4.3 CC(C)c1cc(Cc2c[nH]cn2)c(C(C)C)s1 10.1021/jm0003891
CHEMBL171323 66241 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 248 4 1 2 4.3 CC(C)c1cc(Cc2c[nH]cn2)c(C(C)C)s1 10.1021/jm0003891
CHEMBL1744274 66241 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 248 4 1 2 4.3 CC(C)c1cc(Cc2c[nH]cn2)c(C(C)C)s1 10.1021/jm0003891
118716713 121785 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 487 6 0 7 2.4 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342866 121785 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 487 6 0 7 2.4 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
11046644 37477 0 None -33 6 Human 7.9 pKi = 7.9 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 361 6 0 4 4.0 COc1cccc2c(CCCN3CCN(c4ccccn4)CC3)cccc12 10.1021/jm010866v
CHEMBL139505 37477 0 None -33 6 Human 7.9 pKi = 7.9 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 361 6 0 4 4.0 COc1cccc2c(CCCN3CCN(c4ccccn4)CC3)cccc12 10.1021/jm010866v
3567002 10160 9 None -58 3 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 426 7 1 6 2.0 O=c1[nH]cc(c(=O)n1CCCN1CCN(CC1)c1ccccc1OCC(F)(F)F)C 10.1016/s0960-894x(03)00305-6
7381 10160 9 None -58 3 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 426 7 1 6 2.0 O=c1[nH]cc(c(=O)n1CCCN1CCN(CC1)c1ccccc1OCC(F)(F)F)C 10.1016/s0960-894x(03)00305-6
CHEMBL56331 10160 9 None -58 3 Human 7.9 pKi = 7.9 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 426 7 1 6 2.0 O=c1[nH]cc(c(=O)n1CCCN1CCN(CC1)c1ccccc1OCC(F)(F)F)C 10.1016/s0960-894x(03)00305-6
44358574 126147 0 None -54 5 Human 7.9 pKi = 7.9 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 340 9 1 4 4.0 COc1cccc2c1CCCC2CCCNCCOc1ccccn1 10.1021/jm010866v
CHEMBL344432 126147 0 None -54 5 Human 7.9 pKi = 7.9 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 340 9 1 4 4.0 COc1cccc2c1CCCC2CCCNCCOc1ccccn1 10.1021/jm010866v
11430182 205457 0 None -3 2 Rat 7.9 pKi = 7.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1021/jm030944+
CHEMBL57999 205457 0 None -3 2 Rat 7.9 pKi = 7.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cccc(Cl)c2Cl)CC1 10.1021/jm030944+
71817549 109357 0 None -15 7 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 356 7 2 6 2.5 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)NCC2 10.1021/jm400867d
CHEMBL3040803 109357 0 None -15 7 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 356 7 2 6 2.5 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)NCC2 10.1021/jm400867d
CHEMBL3216590 109357 0 None -15 7 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 356 7 2 6 2.5 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)NCC2 10.1021/jm400867d
10721171 44484 0 None -398 3 Human 6.9 pKi = 6.9 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 539 10 0 6 6.2 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL145770 44484 0 None -398 3 Human 6.9 pKi = 6.9 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 539 10 0 6 6.2 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10815240 213631 0 None -851 3 Human 6.9 pKi = 6.9 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 2 3 4.5 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N(C)C(=O)N1 10.1021/jm990612y
CHEMBL90606 213631 0 None -851 3 Human 6.9 pKi = 6.9 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 2 3 4.5 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N(C)C(=O)N1 10.1021/jm990612y
10579632 42359 0 None -23 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 611 9 2 7 5.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
CHEMBL143940 42359 0 None -23 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 611 9 2 7 5.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
10627329 44217 0 None -24 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 595 7 2 6 4.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145525 44217 0 None -24 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 595 7 2 6 4.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
10508330 125572 0 None -602 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 638 8 2 5 5.9 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)(c3ccc(F)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL342126 125572 0 None -602 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 638 8 2 5 5.9 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)(c3ccc(F)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
10792536 213555 0 None -63 3 Human 5.9 pKi = 5.9 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 540 7 3 3 4.7 O=C1NC(C(F)(F)F)=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N1 10.1021/jm990612y
CHEMBL90184 213555 0 None -63 3 Human 5.9 pKi = 5.9 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 540 7 3 3 4.7 O=C1NC(C(F)(F)F)=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N1 10.1021/jm990612y
11747739 20007 0 None -1 4 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 237 4 2 4 0.8 C[S+]([O-])c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1191324 20007 0 None -1 4 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 237 4 2 4 0.8 C[S+]([O-])c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL542402 20007 0 None -1 4 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 237 4 2 4 0.8 C[S+]([O-])c1ccccc1NCC1=NCCN1 10.1021/jm000542r
9830741 214635 1 None -660 7 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Alpha1D human adrenergic receptors, using [125I]HEAT as radioligand.Binding affinity towards Alpha1D human adrenergic receptors, using [125I]HEAT as radioligand.
ChEMBL 475 6 1 4 5.0 C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm000085e
CHEMBL96467 214635 1 None -660 7 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Alpha1D human adrenergic receptors, using [125I]HEAT as radioligand.Binding affinity towards Alpha1D human adrenergic receptors, using [125I]HEAT as radioligand.
ChEMBL 475 6 1 4 5.0 C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm000085e
9830741 214635 1 None -660 7 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assayTested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assay
ChEMBL 475 6 1 4 5.0 C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1016/s0960-894x(00)00524-2
CHEMBL96467 214635 1 None -660 7 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assayTested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assay
ChEMBL 475 6 1 4 5.0 C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1016/s0960-894x(00)00524-2
134143085 152628 0 None -79 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 323 6 1 4 4.2 c1ccc(OCCNCC2CSC3(CCCCC3)S2)cc1 10.1016/j.ejmech.2016.09.050
CHEMBL3917316 152628 0 None -79 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 323 6 1 4 4.2 c1ccc(OCCNCC2CSC3(CCCCC3)S2)cc1 10.1016/j.ejmech.2016.09.050
10198248 194228 40 None -56 6 Human 4.9 pKi = 4.9 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 213 1 2 5 1.0 c1cnc2cc(NC3=NCCN3)ccc2n1 10.1016/0960-894X(95)00391-6
CHEMBL49395 194228 40 None -56 6 Human 4.9 pKi = 4.9 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 213 1 2 5 1.0 c1cnc2cc(NC3=NCCN3)ccc2n1 10.1016/0960-894X(95)00391-6
10626910 210563 0 None -537 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 572 10 2 8 3.2 COc1ccc(N2C(=O)c3ccc(C(=O)NC[C@H](O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
CHEMBL68203 210563 0 None -537 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 572 10 2 8 3.2 COc1ccc(N2C(=O)c3ccc(C(=O)NC[C@H](O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
10769331 118310 0 None -239 6 Human 6.9 pKi = 6.9 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 566 9 2 7 5.9 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(Cl)c([N+](=O)[O-])c1 10.1021/jm980077m
CHEMBL327931 118310 0 None -239 6 Human 6.9 pKi = 6.9 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 566 9 2 7 5.9 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(Cl)c([N+](=O)[O-])c1 10.1021/jm980077m
155531279 178412 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@H]1OCCO[C@H]1c1ccccc1 10.1016/j.ejmech.2019.02.056
CHEMBL4465749 178412 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@H]1OCCO[C@H]1c1ccccc1 10.1016/j.ejmech.2019.02.056
44568818 194484 0 None -3 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)CO2)cc1 10.1021/jm800461k
CHEMBL495289 194484 0 None -3 4 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)CO2)cc1 10.1021/jm800461k
44298644 169906 0 None -31 3 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 454 7 1 6 2.6 Cc1c[nH]c(=O)n(CC(C)(C)CN2CCN(c3ccccc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
CHEMBL417758 169906 0 None -31 3 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 454 7 1 6 2.6 Cc1c[nH]c(=O)n(CC(C)(C)CN2CCN(c3ccccc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
44298780 203327 0 None -25 3 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 478 7 3 7 0.9 C[C@]1(O)C(=O)N(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)C(=O)N[C@H]1O 10.1016/s0960-894x(03)00305-6
CHEMBL56375 203327 0 None -25 3 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 478 7 3 7 0.9 C[C@]1(O)C(=O)N(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)C(=O)N[C@H]1O 10.1016/s0960-894x(03)00305-6
11325675 164333 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 353 4 0 4 2.0 O=C1C=CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL408034 164333 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 353 4 0 4 2.0 O=C1C=CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
9944409 14385 0 None -34 5 Rat 5.9 pKi = 5.9 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 307 3 3 4 2.0 CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL108804 14385 0 None -34 5 Rat 5.9 pKi = 5.9 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 307 3 3 4 2.0 CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
9944409 14385 0 None -34 5 Rat 5.9 pKi = 5.9 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 307 3 3 4 2.0 CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL108804 14385 0 None -34 5 Rat 5.9 pKi = 5.9 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 307 3 3 4 2.0 CS(=O)(=O)Nc1c(O)ccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
123981 23231 22 None -69 8 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1 10.1021/jm00019a001
CHEMBL123349 23231 22 None -69 8 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1 10.1021/jm00019a001
CHEMBL536803 23231 22 None -69 8 Human 6.9 pKi = 6.9 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1 10.1021/jm00019a001
126720252 171454 0 None -44 12 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by scintillation counting methodDisplacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by scintillation counting method
ChEMBL 697 15 2 6 9.2 NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 10.1021/acs.jmedchem.8b00168
CHEMBL4216870 171454 0 None -44 12 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by scintillation counting methodDisplacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by scintillation counting method
ChEMBL 697 15 2 6 9.2 NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1 10.1021/acs.jmedchem.8b00168
44289344 175325 0 None -10 3 Human 6.9 pKi = 6.9 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 441 8 1 3 4.8 Cc1ccc(C(C(=O)NCCCN2CCN(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL435576 175325 0 None -10 3 Human 6.9 pKi = 6.9 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 441 8 1 3 4.8 Cc1ccc(C(C(=O)NCCCN2CCN(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
10415156 127916 0 None -1819 4 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 550 8 3 5 3.8 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL357628 127916 0 None -1819 4 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 550 8 3 5 3.8 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
57469 25638 125 None 1 3 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 240 2 1 4 2.8 CC(C)Cn1cnc2c(N)nc3ccccc3c21 nan
CHEMBL1282 25638 125 None 1 3 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 240 2 1 4 2.8 CC(C)Cn1cnc2c(N)nc3ccccc3c21 nan
136680384 214434 0 None -288 6 Human 5.9 pKi = 5.9 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 694 16 4 8 4.9 CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
44328799 214434 0 None -288 6 Human 5.9 pKi = 5.9 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 694 16 4 8 4.9 CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
CHEMBL95290 214434 0 None -288 6 Human 5.9 pKi = 5.9 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 694 16 4 8 4.9 CCNC(=O)C1=C(CC)NC(COCCN)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
44426404 149344 0 None 1 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 498 7 1 6 4.4 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1ccc2c(c1)OCO2 10.1016/j.bmcl.2007.04.098
CHEMBL389104 149344 0 None 1 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 498 7 1 6 4.4 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1ccc2c(c1)OCO2 10.1016/j.bmcl.2007.04.098
44308443 210732 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 413 6 0 5 4.0 COc1ccccc1N1CCN(Cc2ccc(CN3CCCCCC3=O)s2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL69339 210732 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 413 6 0 5 4.0 COc1ccccc1N1CCN(Cc2ccc(CN3CCCCCC3=O)s2)CC1 10.1016/s0960-894x(02)00347-5
49781681 24658 0 None -7 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 428 2 0 3 6.3 Cc1cc(C)c(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)c(C)c1 10.1021/jm100652h
CHEMBL1259098 24658 0 None -7 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 428 2 0 3 6.3 Cc1cc(C)c(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)c(C)c1 10.1021/jm100652h
145963755 168813 0 None -1 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 465 5 2 9 2.2 COc1cc2nc(N3CCC[C@H](NC(=O)[C@@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
CHEMBL4160032 168813 0 None -1 3 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 465 5 2 9 2.2 COc1cc2nc(N3CCC[C@H](NC(=O)[C@@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
118716721 121793 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 5 1 6 3.3 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)Nc4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342874 121793 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 5 1 6 3.3 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)Nc4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
52942047 23437 0 None -9 4 Human 7.9 pKi = 7.9 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 451 7 0 6 2.7 COc1ccccc1N1CCN(C[C@H]2CO[C@](CN3CCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242444 23437 0 None -9 4 Human 7.9 pKi = 7.9 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 451 7 0 6 2.7 COc1ccccc1N1CCN(C[C@H]2CO[C@](CN3CCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
44420412 91571 0 None 3 3 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 470 5 1 7 3.4 COc1ccc(Cl)cc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL223289 91571 0 None 3 3 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 470 5 1 7 3.4 COc1ccc(Cl)cc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 10.1016/j.bmcl.2006.09.034
127046693 146445 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Affinity Biochemical interaction (Binding assay) EUB0000341aCl ADRA1DAffinity Biochemical interaction (Binding assay) EUB0000341aCl ADRA1D
ChEMBL 300 3 2 4 2.2 C[C@@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.6019/CHEMBL5210307
CHEMBL3797887 146445 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Affinity Biochemical interaction (Binding assay) EUB0000341aCl ADRA1DAffinity Biochemical interaction (Binding assay) EUB0000341aCl ADRA1D
ChEMBL 300 3 2 4 2.2 C[C@@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.6019/CHEMBL5210307
CHEMBL4762646 146445 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Affinity Biochemical interaction (Binding assay) EUB0000341aCl ADRA1DAffinity Biochemical interaction (Binding assay) EUB0000341aCl ADRA1D
ChEMBL 300 3 2 4 2.2 C[C@@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.6019/CHEMBL5210307
213 10625 55 None -4 43 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
2717 10625 55 None -4 43 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
5533 10625 55 None -4 43 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
CHEMBL621 10625 55 None -4 43 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
DB00656 10625 55 None -4 43 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 nan
127046693 146445 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 300 3 2 4 2.2 C[C@@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
CHEMBL3797887 146445 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 300 3 2 4 2.2 C[C@@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
CHEMBL4762646 146445 0 None 2 2 Human 6.9 pKi = 6.9 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 300 3 2 4 2.2 C[C@@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
44308654 210363 0 None 3 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 401 6 1 6 3.4 COc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3O)s2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL66823 210363 0 None 3 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 401 6 1 6 3.4 COc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3O)s2)CC1 10.1016/s0960-894x(02)00347-5
9959689 108590 0 None -281 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 568 7 2 7 3.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL300222 108590 0 None -281 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 568 7 2 7 3.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
44295133 195507 0 None -14 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 586 7 2 5 5.0 O=C1OCC2=C1C(c1ccc(F)c(F)c1)N(C(=O)NCCCN1CCC(c3ccccc3)(c3ccccc3)CC1)C(=O)N2 10.1016/s0960-894x(99)00653-8
CHEMBL50490 195507 0 None -14 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 586 7 2 5 5.0 O=C1OCC2=C1C(c1ccc(F)c(F)c1)N(C(=O)NCCCN1CCC(c3ccccc3)(c3ccccc3)CC1)C(=O)N2 10.1016/s0960-894x(99)00653-8
44295170 108599 0 None -20 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 554 6 2 7 2.8 COC(=O)C1(c2ccccc2)CCN(CCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL300272 108599 0 None -20 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 554 6 2 7 2.8 COC(=O)C1(c2ccccc2)CCN(CCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
44288792 107092 0 None -199 3 Human 5.9 pKi = 5.9 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 451 8 1 3 5.5 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(Cl)cc2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL289339 107092 0 None -199 3 Human 5.9 pKi = 5.9 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 451 8 1 3 5.5 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(Cl)cc2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
44289089 171364 0 None -5 3 Human 5.9 pKi = 5.9 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 10 1 6 3.2 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)CCc2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL42156 171364 0 None -5 3 Human 5.9 pKi = 5.9 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 10 1 6 3.2 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)CCc2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(00)00307-3
5624 39467 14 None -39 10 Human 4.9 pKi = 4.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 520 5 1 8 4.2 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 nan
CHEMBL1203324 39467 14 None -39 10 Human 4.9 pKi = 4.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 520 5 1 8 4.2 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 nan
CHEMBL141343 39467 14 None -39 10 Human 4.9 pKi = 4.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 520 5 1 8 4.2 Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2 nan
127036932 144126 0 None -43 22 Human 5.9 pKi = 5.9 Binding
Binding affinity to alpha-1D adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-1D adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 274 7 1 1 4.0 C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 10.1016/j.bmcl.2015.12.053
CHEMBL3752900 144126 0 None -43 22 Human 5.9 pKi = 5.9 Binding
Binding affinity to alpha-1D adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-1D adrenergic receptor (unknown origin) by competition binding assay
ChEMBL 274 7 1 1 4.0 C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12 10.1016/j.bmcl.2015.12.053
53328115 70157 0 None 2 3 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 407 6 0 5 2.8 COc1ccccc1N1CCN(CCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796028 70157 0 None 2 3 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 407 6 0 5 2.8 COc1ccccc1N1CCN(CCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
136 10065 32 None -107 16 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
223 10065 32 None -107 16 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
643606 10065 32 None -107 16 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
CHEMBL10347 10065 32 None -107 16 Human 5.9 pKi = 5.9 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
9830741 214635 1 None -660 7 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Alpha1D dog adrenergic receptors, using [125I]-HEAT as radioligand.Binding affinity towards Alpha1D dog adrenergic receptors, using [125I]-HEAT as radioligand.
ChEMBL 475 6 1 4 5.0 C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm000085e
CHEMBL96467 214635 1 None -660 7 Human 6.9 pKi = 6.9 Binding
Binding affinity towards Alpha1D dog adrenergic receptors, using [125I]-HEAT as radioligand.Binding affinity towards Alpha1D dog adrenergic receptors, using [125I]-HEAT as radioligand.
ChEMBL 475 6 1 4 5.0 C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm000085e
1971 9641 38 None -6 30 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
2404 9641 38 None -6 30 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
4543 9641 38 None -6 30 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
CHEMBL445 9641 38 None -6 30 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
DB00540 9641 38 None -6 30 Human 6.9 pKi = 6.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 nan
124 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
2032 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
4636 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
CHEMBL762 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
DB00935 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm000542r
4038180 6992 14 None -141 8 Rat 5.9 pKi = 5.9 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
480 6992 14 None -141 8 Rat 5.9 pKi = 5.9 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
CHEMBL109783 6992 14 None -141 8 Rat 5.9 pKi = 5.9 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm960354u
71817857 98900 0 None -3 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 354 7 2 5 3.0 COc1ccc2cc[nH]c2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL2419766 98900 0 None -3 4 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 354 7 2 5 3.0 COc1ccc2cc[nH]c2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm400867d
19085869 174904 0 None -112 3 Human 6.9 pKi = 6.9 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 469 6 0 7 3.2 Cc1ccc2oc(=O)n(C3CCN(CCCCN4C(=O)c5ccccc5S4(=O)=O)CC3)c2c1 10.1016/s0960-894x(98)00446-6
CHEMBL432947 174904 0 None -112 3 Human 6.9 pKi = 6.9 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 469 6 0 7 3.2 Cc1ccc2oc(=O)n(C3CCN(CCCCN4C(=O)c5ccccc5S4(=O)=O)CC3)c2c1 10.1016/s0960-894x(98)00446-6
44331090 215172 0 None -6 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 464 5 1 5 4.3 CS(=O)(=O)Nc1ccc2c(c1)OC1(CCN(CCc3cccc4ccccc34)CC1)CC2=O 10.1016/s0960-894x(98)00732-x
CHEMBL99614 215172 0 None -6 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 464 5 1 5 4.3 CS(=O)(=O)Nc1ccc2c(c1)OC1(CCN(CCc3cccc4ccccc34)CC1)CC2=O 10.1016/s0960-894x(98)00732-x
10602912 109515 0 None -301 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 558 9 3 8 2.9 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(O)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL304977 109515 0 None -301 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 558 9 3 8 2.9 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(O)cc2)C3=O)CC1 10.1021/jm9905918
10674133 170199 0 None -32 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 546 9 2 7 2.9 CCOc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
CHEMBL419624 170199 0 None -32 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 546 9 2 7 2.9 CCOc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
10032383 116887 0 None -812 6 Human 5.9 pKi = 5.9 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
136680387 116887 0 None -812 6 Human 5.9 pKi = 5.9 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL323579 116887 0 None -812 6 Human 5.9 pKi = 5.9 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
12134995 108919 0 None 1 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 318 5 1 5 2.6 COc1ccccc1N1CCN(Cc2ccc(CO)s2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL302495 108919 0 None 1 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 318 5 1 5 2.6 COc1ccccc1N1CCN(Cc2ccc(CO)s2)CC1 10.1016/s0960-894x(02)00347-5
10903226 20542 0 None -1 4 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 281 6 2 5 1.3 CCCS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1195368 20542 0 None -1 4 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 281 6 2 5 1.3 CCCS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL554416 20542 0 None -1 4 Human 5.9 pKi = 5.9 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 281 6 2 5 1.3 CCCS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
124 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
2032 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
4636 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
CHEMBL762 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
DB00935 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C nan
11211017 205013 0 None 1 6 Human 7.9 pKi = 7.9 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 373 4 0 4 2.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)cc2)CC1 10.1021/jm0491391
CHEMBL57546 205013 0 None 1 6 Human 7.9 pKi = 7.9 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 373 4 0 4 2.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)cc2)CC1 10.1021/jm0491391
44431590 94754 0 None 2 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 555 8 1 6 4.9 COc1ccc(C(F)(F)F)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234231 94754 0 None 2 4 Human 7.9 pKi = 7.9 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 555 8 1 6 4.9 COc1ccc(C(F)(F)F)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
10531 8202 21 None -28 24 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
121 8202 21 None -28 24 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
888 8202 21 None -28 24 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
CHEMBL1732 8202 21 None -28 24 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
DB00320 8202 21 None -28 24 Human 7.9 pKi = 7.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
10650726 40532 0 None -141 3 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 571 9 2 7 3.8 CCOc1ccccc1N1CCN(CCCNC(=O)N2C(=O)NC(C)=C(C(=O)OC)C2c2ccc(F)c(F)c2)CC1 10.1021/jm990202+
CHEMBL142251 40532 0 None -141 3 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 571 9 2 7 3.8 CCOc1ccccc1N1CCN(CCCNC(=O)N2C(=O)NC(C)=C(C(=O)OC)C2c2ccc(F)c(F)c2)CC1 10.1021/jm990202+
10626726 40718 0 None -70 3 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 561 7 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3Cl)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL142398 40718 0 None -70 3 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 561 7 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3Cl)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
46934639 23442 0 None -16 4 Human 7.9 pKi = 7.9 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 465 7 0 6 3.1 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3CCCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242541 23442 0 None -16 4 Human 7.9 pKi = 7.9 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 465 7 0 6 3.1 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3CCCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
52947088 23882 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 391 11 1 4 4.9 Cc1cccc(C)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1255003 23882 0 None -1 4 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 391 11 1 4 4.9 Cc1cccc(C)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
53327991 70175 0 None 7 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 449 8 0 5 3.7 COc1ccccc1N1CCN(CCCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796046 70175 0 None 7 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 449 8 0 5 3.7 COc1ccccc1N1CCN(CCCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
11994797 19086 0 None -5 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 369 7 1 5 3.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)CCCC2 10.1021/jm060358r
CHEMBL1185017 19086 0 None -5 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 369 7 1 5 3.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)CCCC2 10.1021/jm060358r
CHEMBL383938 19086 0 None -5 7 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 369 7 1 5 3.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)CCCC2 10.1021/jm060358r
127040061 143704 0 None -3 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL3739932 143704 0 None -3 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL3742489 143704 0 None -3 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
44431620 94573 0 None -4 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 570 7 1 6 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cnc(Cl)c(Br)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233790 94573 0 None -4 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 570 7 1 6 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cnc(Cl)c(Br)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
11245925 205922 0 None 8 2 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 378 7 0 4 3.4 CN(CCOc1ccccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
CHEMBL58930 205922 0 None 8 2 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 378 7 0 4 3.4 CN(CCOc1ccccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
118716698 121770 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 364 4 0 6 2.5 COc1ccccc1N1CCN(CC2COC3(CCSCC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342852 121770 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 364 4 0 6 2.5 COc1ccccc1N1CCN(CC2COC3(CCSCC3)O2)CC1 10.1016/j.ejmech.2014.09.070
11984570 99579 0 None -2 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 465 5 0 5 4.3 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccc(F)c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
CHEMBL243694 99579 0 None -2 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 465 5 0 5 4.3 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccc(F)c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
10651219 40512 0 None -1412 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 600 10 3 8 2.1 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 10.1021/jm990202+
CHEMBL142236 40512 0 None -1412 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 600 10 3 8 2.1 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 10.1021/jm990202+
10745766 44258 0 None -199 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 578 9 3 8 2.7 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1021/jm990200p
CHEMBL145562 44258 0 None -199 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 578 9 3 8 2.7 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1021/jm990200p
10438280 108375 0 None -1412 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990200p
CHEMBL298713 108375 0 None -1412 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990200p
10722099 127872 0 None -467 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 588 8 3 7 2.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1cc(F)c(F)c(F)c1 10.1021/jm990202+
CHEMBL357172 127872 0 None -467 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 588 8 3 7 2.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1cc(F)c(F)c(F)c1 10.1021/jm990202+
10438280 108375 0 None -1412 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL298713 108375 0 None -1412 3 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
21712258 176042 0 None -194 2 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 465 8 1 3 5.5 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(01)00320-1
CHEMBL44124 176042 0 None -194 2 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 465 8 1 3 5.5 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(01)00320-1
21712258 176042 0 None -194 2 Human 5.9 pKi = 5.9 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 465 8 1 3 5.5 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL44124 176042 0 None -194 2 Human 5.9 pKi = 5.9 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 465 8 1 3 5.5 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
56946577 78287 0 None -40 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 415 9 1 4 4.6 COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)C1=O 10.1021/jm200421e
CHEMBL1946782 78287 0 None -40 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 415 9 1 4 4.6 COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)C1=O 10.1021/jm200421e
CHEMBL1962754 78287 0 None -40 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 415 9 1 4 4.6 COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)C1=O 10.1021/jm200421e
10892762 85596 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 326 7 1 4 3.8 COc1cccc(C2CCC(NCCOc3ccccn3)CC2)c1 10.1021/jm010866v
CHEMBL2112774 85596 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 326 7 1 4 3.8 COc1cccc(C2CCC(NCCOc3ccccn3)CC2)c1 10.1021/jm010866v
10660 21188 58 None -38 12 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 469 6 1 7 3.0 CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O nan
CHEMBL1200406 21188 58 None -38 12 Human 5.9 pKi = 5.9 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 469 6 1 7 3.0 CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O nan
10811627 212329 0 None -173 3 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 412 7 0 6 3.3 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)no2)CC1 10.1016/s0960-894x(02)00436-5
CHEMBL538529 212329 0 None -173 3 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 412 7 0 6 3.3 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)no2)CC1 10.1016/s0960-894x(02)00436-5
CHEMBL81093 212329 0 None -173 3 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 412 7 0 6 3.3 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)no2)CC1 10.1016/s0960-894x(02)00436-5
10793963 106448 0 None -23 6 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 622 11 2 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm960697s
CHEMBL284470 106448 0 None -23 6 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 622 11 2 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm960697s
CHEMBL4576555 220796 5 None -1 19 Human 5.8 pKi = 5.8 Binding
GPCRScan assay: inhibition of Alpha1DGPCRScan assay: inhibition of Alpha1D
ChEMBL None None None CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 10.6019/CHEMBL4507307
CHEMBL4576555 220796 5 None -1 19 Human 5.8 pKi = 5.8 Binding
GPCRScan assay: inhibition of Alpha1DGPCRScan assay: inhibition of Alpha1D
ChEMBL None None None CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1 10.6019/CHEMBL4507307
10416624 116427 0 None -457 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 634 14 4 10 2.0 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(COCCN)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(99)00484-9
136806219 116427 0 None -457 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 634 14 4 10 2.0 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(COCCN)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(99)00484-9
CHEMBL322405 116427 0 None -457 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 634 14 4 10 2.0 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(COCCN)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(99)00484-9
11994673 19088 0 None -7 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 419 7 1 5 4.5 COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL1185036 19088 0 None -7 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 419 7 1 5 4.5 COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL385371 19088 0 None -7 6 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 419 7 1 5 4.5 COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
11801861 125566 0 None -181 3 Human 4.8 pKi = 4.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 609 6 2 6 4.0 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)N2CCC(N3CCC(C(=O)OC)(c4ccccc4)CC3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL342064 125566 0 None -181 3 Human 4.8 pKi = 4.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 609 6 2 6 4.0 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)N2CCC(N3CCC(C(=O)OC)(c4ccccc4)CC3)CC2)C(=O)N1 10.1021/jm990201h
4038180 6992 14 None -141 8 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
480 6992 14 None -141 8 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
CHEMBL109783 6992 14 None -141 8 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
4038180 6992 14 None -141 8 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm030551a
480 6992 14 None -141 8 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm030551a
CHEMBL109783 6992 14 None -141 8 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm030551a
127046693 146445 0 None 2 2 Human 5.8 pKi = 5.8 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000341aCl ADRA1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000341aCl ADRA1D
ChEMBL 300 3 2 4 2.2 C[C@@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.6019/CHEMBL5212743
CHEMBL3797887 146445 0 None 2 2 Human 5.8 pKi = 5.8 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000341aCl ADRA1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000341aCl ADRA1D
ChEMBL 300 3 2 4 2.2 C[C@@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.6019/CHEMBL5212743
CHEMBL4762646 146445 0 None 2 2 Human 5.8 pKi = 5.8 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000341aCl ADRA1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000341aCl ADRA1D
ChEMBL 300 3 2 4 2.2 C[C@@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.6019/CHEMBL5212743
44331174 10941 0 None -4 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 355 3 0 2 4.9 O=C1c2ccccc2CC12CCN(CCc1cccc3ccccc13)CC2 10.1016/s0960-894x(98)00732-x
CHEMBL100052 10941 0 None -4 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 355 3 0 2 4.9 O=C1c2ccccc2CC12CCN(CCc1cccc3ccccc13)CC2 10.1016/s0960-894x(98)00732-x
4189 213701 96 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -18 34 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
44431590 94755 0 None -7 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 555 8 1 6 4.9 COc1ccc(C(F)(F)F)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234232 94755 0 None -7 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 555 8 1 6 4.9 COc1ccc(C(F)(F)F)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
44431612 155643 0 None 2 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cc(Cl)ccc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL394139 155643 0 None 2 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cc(Cl)ccc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
10674564 210716 0 None -83 3 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 569 10 1 7 4.3 CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL69264 210716 0 None -83 3 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 569 10 1 7 4.3 CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
31101 7516 40 None -7 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
35 7516 40 None -7 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
403 7516 40 None -7 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
CHEMBL493 7516 40 None -7 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
DB01200 7516 40 None -7 35 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C nan
26987 7736 33 None -39 21 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
6063 7736 33 None -39 21 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
671 7736 33 None -39 21 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
CHEMBL1626 7736 33 None -39 21 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
DB00283 7736 33 None -39 21 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C nan
58149995 146844 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 353 4 2 5 1.7 CC(c1cccc(S(C)(=O)=O)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
CHEMBL3800449 146844 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 353 4 2 5 1.7 CC(c1cccc(S(C)(=O)=O)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
44308466 210568 0 None -1 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 429 7 0 7 3.2 COC(=O)[C@@H]1CCCN1Cc1ccc(CN2CCN(c3ccccc3OC)CC2)s1 10.1016/s0960-894x(02)00347-5
CHEMBL68241 210568 0 None -1 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 429 7 0 7 3.2 COC(=O)[C@@H]1CCCN1Cc1ccc(CN2CCN(c3ccccc3OC)CC2)s1 10.1016/s0960-894x(02)00347-5
16041091 101996 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL256041 101996 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
11071135 214787 0 None -6 8 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 500 6 0 6 4.6 CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O 10.1021/jm020938y
CHEMBL97333 214787 0 None -6 8 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 500 6 0 6 4.6 CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O 10.1021/jm020938y
71508712 93843 0 None -95 5 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 389 3 0 5 4.4 CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncn(C)n4)cc23)CC1 10.1016/j.bmc.2012.10.049
CHEMBL2326175 93843 0 None -95 5 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 389 3 0 5 4.4 CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncn(C)n4)cc23)CC1 10.1016/j.bmc.2012.10.049
10699164 43802 0 None -151 3 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 552 7 2 7 3.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C#N)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145190 43802 0 None -151 3 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 552 7 2 7 3.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C#N)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
11994667 18603 0 None -2 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1ccc(-c2ccccc2)cc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182143 18603 0 None -2 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1ccc(-c2ccccc2)cc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL214694 18603 0 None -2 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1ccc(-c2ccccc2)cc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
52944674 23894 0 None -3 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 395 11 3 6 3.7 Oc1cccc(O)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1255085 23894 0 None -3 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 395 11 3 6 3.7 Oc1cccc(O)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
9958160 205633 0 None 29 4 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 515 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(I)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL58384 205633 0 None 29 4 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 515 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(I)ccc2Cl)CC1 10.1021/jm030944+
11304135 202438 0 None -1 2 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 400 5 0 6 2.4 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2[N+](=O)[O-])CC1 10.1021/jm030944+
CHEMBL55647 202438 0 None -1 2 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 400 5 0 6 2.4 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2[N+](=O)[O-])CC1 10.1021/jm030944+
50905589 63128 0 None -1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 406 7 2 6 2.1 COc1ccc(C[C@@H](C)NC[C@@H]2Oc3ccccc3O[C@@H]2C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
CHEMBL1630942 63128 0 None -1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 406 7 2 6 2.1 COc1ccc(C[C@@H](C)NC[C@@H]2Oc3ccccc3O[C@@H]2C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
11338016 42750 0 None -1 3 Human 7.8 pKi = 7.8 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 381 5 2 6 3.0 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccco1)C3 10.1021/jm030952q
CHEMBL144286 42750 0 None -1 3 Human 7.8 pKi = 7.8 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 381 5 2 6 3.0 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccco1)C3 10.1021/jm030952q
3894573 10166 6 None -35 5 Human 7.8 pKi = 7.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 412 10 2 3 5.6 Clc1ccc2c(c1)c(c[nH]2)CC(NCCOc1ccccc1OCC1CC1)(C)C 10.1021/jm960697s
495 10166 6 None -35 5 Human 7.8 pKi = 7.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 412 10 2 3 5.6 Clc1ccc2c(c1)c(c[nH]2)CC(NCCOc1ccccc1OCC1CC1)(C)C 10.1021/jm960697s
CHEMBL88272 10166 6 None -35 5 Human 7.8 pKi = 7.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 412 10 2 3 5.6 Clc1ccc2c(c1)c(c[nH]2)CC(NCCOc1ccccc1OCC1CC1)(C)C 10.1021/jm960697s
53327748 70162 0 None -2 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 435 8 0 5 3.5 COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796033 70162 0 None -2 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 435 8 0 5 3.5 COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
155555859 183006 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 433 11 1 5 4.6 COc1ccccc1OCCNCC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4551941 183006 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 433 11 1 5 4.6 COc1ccccc1OCCNCC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4594653 183006 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 433 11 1 5 4.6 COc1ccccc1OCCNCC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
11994551 18612 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 369 7 1 5 3.4 COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)CCCC2 10.1021/jm060358r
CHEMBL1182179 18612 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 369 7 1 5 3.4 COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)CCCC2 10.1021/jm060358r
CHEMBL217143 18612 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 369 7 1 5 3.4 COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)CCCC2 10.1021/jm060358r
44298746 202411 0 None -19 3 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 452 7 1 6 2.4 Cc1c[nH]c(=O)n(CC2(CN3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)c1=O 10.1016/s0960-894x(03)00305-6
CHEMBL55629 202411 0 None -19 3 Human 7.8 pKi = 7.8 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 452 7 1 6 2.4 Cc1c[nH]c(=O)n(CC2(CN3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)c1=O 10.1016/s0960-894x(03)00305-6
10846051 66234 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 208 3 1 3 2.5 COC(c1c[nH]cn1)c1cscc1C 10.1021/jm0003891
CHEMBL171278 66234 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 208 3 1 3 2.5 COC(c1c[nH]cn1)c1cscc1C 10.1021/jm0003891
CHEMBL1744286 66234 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 208 3 1 3 2.5 COC(c1c[nH]cn1)c1cscc1C 10.1021/jm0003891
10721751 41404 0 None -1513 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 569 10 1 6 4.9 COC(=O)C1=C(C)NC(=O)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL142981 41404 0 None -1513 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 569 10 1 6 4.9 COC(=O)C1=C(C)NC(=O)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
191 7191 98 None -23 29 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
201 7191 98 None -23 29 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
2170 7191 98 None -23 29 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
CHEMBL1113 7191 98 None -23 29 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
DB00543 7191 98 None -23 29 Human 6.8 pKi = 6.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 nan
10531022 127847 0 None -100 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 566 8 2 7 3.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1cccc(F)c1 10.1021/jm990200p
CHEMBL356978 127847 0 None -100 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 566 8 2 7 3.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1cccc(F)c1 10.1021/jm990200p
10721751 41404 0 None -1513 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 569 10 1 6 4.9 COC(=O)C1=C(C)NC(=O)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL142981 41404 0 None -1513 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 569 10 1 6 4.9 COC(=O)C1=C(C)NC(=O)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
10720893 44142 0 None -758 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 526 7 2 5 4.5 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL145459 44142 0 None -758 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 526 7 2 5 4.5 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
4038180 6992 14 None -141 8 Rat 5.8 pKi = 5.8 Binding
Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.3 -1.6)Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.3 -1.6)
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm025550h
480 6992 14 None -141 8 Rat 5.8 pKi = 5.8 Binding
Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.3 -1.6)Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.3 -1.6)
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm025550h
CHEMBL109783 6992 14 None -141 8 Rat 5.8 pKi = 5.8 Binding
Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.3 -1.6)Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.3 -1.6)
ChEMBL 309 3 3 5 1.2 Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1 10.1021/jm025550h
9984150 108546 0 None -891 3 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 519 7 0 4 5.6 Cc1ccc(C2(c3ccc(C)cc3)CC(=O)N(CCCN3CCC(C#N)(c4ccccc4C)CC3)C2=O)cc1 10.1016/s0960-894x(01)00320-1
CHEMBL299914 108546 0 None -891 3 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 519 7 0 4 5.6 Cc1ccc(C2(c3ccc(C)cc3)CC(=O)N(CCCN3CCC(C#N)(c4ccccc4C)CC3)C2=O)cc1 10.1016/s0960-894x(01)00320-1
10097317 206863 0 None -758 3 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 495 8 2 4 4.9 Cc1ccc(C(O)(C(=O)NCCCN2CCC(C#N)(c3ccccc3C)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(01)00320-1
CHEMBL59590 206863 0 None -758 3 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 495 8 2 4 4.9 Cc1ccc(C(O)(C(=O)NCCCN2CCC(C#N)(c3ccccc3C)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(01)00320-1
44288492 170193 0 None -3 2 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 439 9 1 6 2.9 COC(=O)C1(c2ccccc2)CCN(CCNC(=O)CCc2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL41959 170193 0 None -3 2 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 439 9 1 6 2.9 COC(=O)C1(c2ccccc2)CCN(CCNC(=O)CCc2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(00)00307-3
11801828 213323 0 None -93 6 Human 5.8 pKi = 5.8 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 606 9 3 6 5.0 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
CHEMBL88628 213323 0 None -93 6 Human 5.8 pKi = 5.8 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 606 9 3 6 5.0 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
53328504 70167 0 None 4 3 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 445 5 0 4 4.0 O=C1CC(c2ccc(Cl)cc2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796038 70167 0 None 4 3 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 445 5 0 4 4.0 O=C1CC(c2ccc(Cl)cc2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
10314056 214929 1 None -1 3 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 322 3 0 4 3.1 O=C1CC2(CCN(CCc3ccccn3)CC2)Oc2ccccc21 10.1016/s0960-894x(98)00732-x
CHEMBL98167 214929 1 None -1 3 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 322 3 0 4 3.1 O=C1CC2(CCN(CCc3ccccn3)CC2)Oc2ccccc21 10.1016/s0960-894x(98)00732-x
12134987 211767 0 None -16 2 Human 5.8 pKi = 5.8 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 414 7 0 6 2.8 CC(C)Oc1ccccc1N1CCN(CC2=NOC(CN3CCCCC3=O)C2)CC1 10.1016/s0960-894x(00)00472-8
CHEMBL76643 211767 0 None -16 2 Human 5.8 pKi = 5.8 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 414 7 0 6 2.8 CC(C)Oc1ccccc1N1CCN(CC2=NOC(CN3CCCCC3=O)C2)CC1 10.1016/s0960-894x(00)00472-8
10770317 210670 0 None -123 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 632 12 2 10 3.2 COc1cc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc(OC)c1OC 10.1021/jm9905918
CHEMBL68913 210670 0 None -123 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 632 12 2 10 3.2 COc1cc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc(OC)c1OC 10.1021/jm9905918
11189412 205250 0 None -18 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.5 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1021/jm030944+
CHEMBL57747 205250 0 None -18 2 Rat 6.8 pKi = 6.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.5 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1 10.1021/jm030944+
25132565 194050 0 None -2 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 313 7 1 4 2.8 c1ccc(OCCNC[C@@H]2COC[C@@H](c3ccccc3)O2)cc1 10.1021/jm800461k
CHEMBL492785 194050 0 None -2 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 313 7 1 4 2.8 c1ccc(OCCNC[C@@H]2COC[C@@H](c3ccccc3)O2)cc1 10.1021/jm800461k
56946579 78288 0 None -44 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 440 6 0 4 4.8 COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1021/jm200421e
CHEMBL1946783 78288 0 None -44 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 440 6 0 4 4.8 COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1021/jm200421e
CHEMBL1962755 78288 0 None -44 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 440 6 0 4 4.8 COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)C2=O)CC1 10.1021/jm200421e
19968568 92114 0 None -2 3 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 323 4 2 5 1.5 COc1ccc2c(c1NS(C)(=O)=O)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
CHEMBL2261353 92114 0 None -2 3 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 323 4 2 5 1.5 COc1ccc2c(c1NS(C)(=O)=O)CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
10674544 125569 0 None -346 3 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 568 6 2 7 3.5 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)C(=O)Oc2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL342111 125569 0 None -346 3 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 568 6 2 7 3.5 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)C(=O)Oc2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
1443 8809 34 None -16 11 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm960697s
33625 8809 34 None -16 11 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm960697s
501 8809 34 None -16 11 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm960697s
CHEMBL279516 8809 34 None -16 11 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm960697s
DB08950 8809 34 None -16 11 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm960697s
9817640 106106 0 None -38 3 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 295 6 1 2 3.6 COc1ccc(CCNCC2CCc3ccccc3C2)cc1 10.1021/jm960697s
CHEMBL282214 106106 0 None -38 3 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 295 6 1 2 3.6 COc1ccc(CCNCC2CCc3ccccc3C2)cc1 10.1021/jm960697s
9809007 179343 8 None -407 6 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm960697s
CHEMBL448620 179343 8 None -407 6 Human 6.8 pKi = 6.8 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm960697s
9904117 16174 3 None -15 5 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL111554 16174 3 None -15 5 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
9904117 16174 3 None -15 5 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL111554 16174 3 None -15 5 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
9944937 118115 0 None -1 2 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 320 4 2 3 2.1 CN(C)S(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL326862 118115 0 None -1 2 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 320 4 2 3 2.1 CN(C)S(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
18187410 111675 0 None -56 3 Human 7.8 pKi = 7.8 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 418 6 1 6 3.5 O=C1c2ccccc2C(=O)N1CCCCN1CCC(n2c(O)nc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL311247 111675 0 None -56 3 Human 7.8 pKi = 7.8 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 418 6 1 6 3.5 O=C1c2ccccc2C(=O)N1CCCCN1CCC(n2c(O)nc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
44431599 94839 0 None -10 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 505 7 1 5 4.8 Cc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1Cl 10.1016/j.bmcl.2007.04.008
CHEMBL234609 94839 0 None -10 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 505 7 1 5 4.8 Cc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1Cl 10.1016/j.bmcl.2007.04.008
13151 7768 0 None -100 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human recombinant alpha1D adrenoceptorBinding affinity to human recombinant alpha1D adrenoceptor
ChEMBL 391 5 1 2 4.9 FC1=CC=C2C(=CNC2=C1)C3CCN(CC3)CCCN4CC5=CC=CC=C5CC4 10.1016/j.bmcl.2015.07.046
9930376 7768 0 None -100 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human recombinant alpha1D adrenoceptorBinding affinity to human recombinant alpha1D adrenoceptor
ChEMBL 391 5 1 2 4.9 FC1=CC=C2C(=CNC2=C1)C3CCN(CC3)CCCN4CC5=CC=CC=C5CC4 10.1016/j.bmcl.2015.07.046
CHEMBL3609360 7768 0 None -100 4 Human 7.8 pKi = 7.8 Binding
Binding affinity to human recombinant alpha1D adrenoceptorBinding affinity to human recombinant alpha1D adrenoceptor
ChEMBL 391 5 1 2 4.9 FC1=CC=C2C(=CNC2=C1)C3CCN(CC3)CCCN4CC5=CC=CC=C5CC4 10.1016/j.bmcl.2015.07.046
10578715 109452 0 None -144 3 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 556 10 1 7 4.2 COc1ccc(N2C(=O)c3ccc(C(=O)NCCCN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
CHEMBL304591 109452 0 None -144 3 Human 7.8 pKi = 7.8 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 556 10 1 7 4.2 COc1ccc(N2C(=O)c3ccc(C(=O)NCCCN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
1212 8443 50 None -18 65 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 8443 50 None -18 65 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 8443 50 None -18 65 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 8443 50 None -18 65 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 8443 50 None -18 65 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
2274 9947 58 None -5 31 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
4917 9947 58 None -5 31 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
7279 9947 58 None -5 31 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
CHEMBL728 9947 58 None -5 31 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
DB00433 9947 58 None -5 31 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 nan
59151542 146813 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 275 4 2 3 2.0 N=c1c(C(N)=O)cc(Cl)cn1CCc1ccccc1 10.1021/acs.jmedchem.5b01528
CHEMBL3800219 146813 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 275 4 2 3 2.0 N=c1c(C(N)=O)cc(Cl)cn1CCc1ccccc1 10.1021/acs.jmedchem.5b01528
44300165 108628 0 None -66 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.5 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL300540 108628 0 None -66 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.5 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
16041265 102112 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL256597 102112 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
49781679 24651 0 None -13 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 414 2 0 3 6.0 Cc1cccc(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)c1C 10.1021/jm100652h
CHEMBL1259080 24651 0 None -13 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 414 2 0 3 6.0 Cc1cccc(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)c1C 10.1021/jm100652h
11234093 206469 0 None -12 3 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 371 4 1 5 2.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2O)CC1 10.1021/jm030944+
CHEMBL59315 206469 0 None -12 3 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 371 4 1 5 2.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2O)CC1 10.1021/jm030944+
46934645 23459 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 465 7 0 7 2.2 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242725 23459 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 465 7 0 7 2.2 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
53327992 70179 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 461 7 0 5 3.6 COc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796050 70179 0 None 1 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 461 7 0 5 3.6 COc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
10688604 31524 0 None 1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 341 5 2 5 2.4 O[C@@H]1[C@H](NC[C@@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1 10.1021/jm991065j
CHEMBL134428 31524 0 None 1 5 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 341 5 2 5 2.4 O[C@@H]1[C@H](NC[C@@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1 10.1021/jm991065j
25130876 199404 0 None -4 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@@H]1CO[C@H](c2ccccc2)CO1 10.1021/jm800461k
CHEMBL521665 199404 0 None -4 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@@H]1CO[C@H](c2ccccc2)CO1 10.1021/jm800461k
9867138 202571 0 None 26 4 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 425 7 0 4 4.1 CN(CCN1C(=O)CC2(CCCC2)CC1=O)CCN(C)c1cc(Cl)ccc1Cl 10.1021/jm030944+
CHEMBL55790 202571 0 None 26 4 Rat 7.8 pKi = 7.8 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 425 7 0 4 4.1 CN(CCN1C(=O)CC2(CCCC2)CC1=O)CCN(C)c1cc(Cl)ccc1Cl 10.1021/jm030944+
44431184 99625 0 None 2 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 515 5 0 5 5.5 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccc(F)cc5c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
CHEMBL243866 99625 0 None 2 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 515 5 0 5 5.5 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccc(F)cc5c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
155565449 183110 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 433 11 1 5 4.6 COc1ccccc1OCCNCC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4579802 183110 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 433 11 1 5 4.6 COc1ccccc1OCCNCC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4595447 183110 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 433 11 1 5 4.6 COc1ccccc1OCCNCC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
3826471 104254 13 None -9 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 296 5 0 3 3.1 COc1ccccc1N1CCN(CCc2ccccc2)CC1 10.1016/j.ejmech.2016.06.052
CHEMBL27021 104254 13 None -9 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 296 5 0 3 3.1 COc1ccccc1N1CCN(CCc2ccccc2)CC1 10.1016/j.ejmech.2016.06.052
10621590 91381 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(OC)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153554 91381 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(OC)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2221148 91381 0 None -1 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(OC)c2O1 10.1016/j.ejmech.2012.09.049
44289261 171691 0 None -33 7 Human 7.8 pKi = 7.8 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 417 9 1 4 5.1 COc1cccc(OC)c1OCCNCC1Cc2ccccc2C(c2ccccc2)C1 10.1021/jm011066n
CHEMBL42231 171691 0 None -33 7 Human 7.8 pKi = 7.8 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 417 9 1 4 5.1 COc1cccc(OC)c1OCCNCC1Cc2ccccc2C(c2ccccc2)C1 10.1021/jm011066n
13442845 146389 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 305 3 2 3 1.9 N=c1c(C(N)=O)cc(Br)cn1Cc1ccccc1 10.1021/acs.jmedchem.5b01528
CHEMBL3797500 146389 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 305 3 2 3 1.9 N=c1c(C(N)=O)cc(Br)cn1Cc1ccccc1 10.1021/acs.jmedchem.5b01528
59151549 146536 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 251 3 2 4 1.4 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccco1 10.1021/acs.jmedchem.5b01528
CHEMBL3798506 146536 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 251 3 2 4 1.4 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccco1 10.1021/acs.jmedchem.5b01528
10576661 213637 0 None -1230 3 Human 6.8 pKi = 6.8 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 479 7 3 4 3.5 N#Cc1ccccc1C1CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
CHEMBL90652 213637 0 None -1230 3 Human 6.8 pKi = 6.8 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 479 7 3 4 3.5 N#Cc1ccccc1C1CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
9809007 179343 8 None -407 6 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
CHEMBL448620 179343 8 None -407 6 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
10768423 108104 0 None -1 3 Rat 6.8 pKi = 6.8 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 525 5 1 8 4.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5nc(-c6ccccc6)cnc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL296711 108104 0 None -1 3 Rat 6.8 pKi = 6.8 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 525 5 1 8 4.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5nc(-c6ccccc6)cnc54)c3=O)C[C@@H]21 10.1021/jm990567u
10626453 128793 0 None -72 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 548 9 0 6 6.2 COC(=O)C1=C(C)N=C(C)N(CCC[C@@H](C)CN2CCC(C#N)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL359430 128793 0 None -72 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 548 9 0 6 6.2 COC(=O)C1=C(C)N=C(C)N(CCC[C@@H](C)CN2CCC(C#N)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10026936 170237 0 None -204 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 8 1 3 5.1 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(F)c(F)c2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL41994 170237 0 None -204 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 8 1 3 5.1 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(F)c(F)c2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
2771 201796 74 None -9 27 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 nan
CHEMBL1200781 201796 74 None -9 27 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 nan
CHEMBL549 201796 74 None -9 27 Human 5.8 pKi = 5.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 nan
2146 9874 67 None -5 9 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
485 9874 67 None -5 9 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
6041 9874 67 None -5 9 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
CHEMBL1215 9874 67 None -5 9 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
DB00388 9874 67 None -5 9 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 10.1021/jm960354u
11079593 210894 0 None -4 4 Human 5.8 pKi = 5.8 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70326 210894 0 None -4 4 Human 5.8 pKi = 5.8 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
1210 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
1213 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
2725 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
33036 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
4411 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
616 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
6976 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
716121 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL1201353 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL1554789 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
CHEMBL505 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
DB01114 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
DB13679 7705 51 None -602 21 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C nan
43260 12254 65 None -1 5 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1007/s00044-004-0020-z
CHEMBL1076 12254 65 None -1 5 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1007/s00044-004-0020-z
9926529 16161 2 None -19 5 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL111496 16161 2 None -19 5 Rat 5.8 pKi = 5.8 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
43260 12254 65 None -1 5 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1021/jm030551a
CHEMBL1076 12254 65 None -1 5 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1021/jm030551a
136806217 214478 0 None -120 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 576 13 4 8 2.7 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
44328806 214478 0 None -120 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 576 13 4 8 2.7 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL95548 214478 0 None -120 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 576 13 4 8 2.7 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
10624993 118464 0 None -660 3 Human 6.8 pKi = 6.8 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 493 7 3 4 3.9 CC1=C(C(=O)NCCCN2CCC(c3ccccc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
CHEMBL328658 118464 0 None -660 3 Human 6.8 pKi = 6.8 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 493 7 3 4 3.9 CC1=C(C(=O)NCCCN2CCC(c3ccccc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
10694274 205801 0 None -1 3 Rat 6.8 pKi = 6.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 437 6 1 5 3.7 COc1cc2c(cc1OC)NC(=O)N(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)C2 10.1021/jm000541z
CHEMBL58585 205801 0 None -1 3 Rat 6.8 pKi = 6.8 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 437 6 1 5 3.7 COc1cc2c(cc1OC)NC(=O)N(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)C2 10.1021/jm000541z
44568918 194135 0 None -1 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNC[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1 10.1021/jm800461k
CHEMBL493284 194135 0 None -1 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNC[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1 10.1021/jm800461k
10508132 113794 0 None -28 6 Human 5.8 pKi = 5.8 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 621 10 2 6 5.5 CC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)N(C)C)=C(C)N1 10.1021/jm980077m
CHEMBL315392 113794 0 None -28 6 Human 5.8 pKi = 5.8 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 621 10 2 6 5.5 CC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)N(C)C)=C(C)N1 10.1021/jm980077m
9922027 122188 0 None -1 3 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 289 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCC=C2c1c[nH]cn1 10.1021/jm030551a
CHEMBL3350265 122188 0 None -1 3 Rat 5.8 pKi = 5.8 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 289 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCC=C2c1c[nH]cn1 10.1021/jm030551a
135398737 7745 93 None -2 90 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
38 7745 93 None -2 90 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
722 7745 93 None -2 90 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
CHEMBL42 7745 93 None -2 90 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
DB00363 7745 93 None -2 90 Human 7.8 pKi = 7.8 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 nan
70820518 174306 0 None 64 3 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 391 7 1 4 3.7 CS(=O)(=O)c1ccc(Cl)cc1CNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
CHEMBL4213747 174306 0 None 64 3 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 391 7 1 4 3.7 CS(=O)(=O)c1ccc(Cl)cc1CNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
CHEMBL4300105 174306 0 None 64 3 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 391 7 1 4 3.7 CS(=O)(=O)c1ccc(Cl)cc1CNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
70820461 174526 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 353 5 1 4 2.9 O=S1(=O)CCC(NCCOc2cc(F)ccc2F)c2ccccc21 10.1016/j.ejmech.2017.07.071
CHEMBL4217445 174526 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 353 5 1 4 2.9 O=S1(=O)CCC(NCCOc2cc(F)ccc2F)c2ccccc21 10.1016/j.ejmech.2017.07.071
CHEMBL4302890 174526 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 353 5 1 4 2.9 O=S1(=O)CCC(NCCOc2cc(F)ccc2F)c2ccccc21 10.1016/j.ejmech.2017.07.071
10934575 211265 0 None 1 6 Human 7.8 pKi = 7.8 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72441 211265 0 None 1 6 Human 7.8 pKi = 7.8 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1 10.1021/jm000542r
50905588 63127 0 None 1 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 406 7 2 6 2.1 COc1ccc(C[C@@H](C)NC[C@H]2Oc3ccccc3O[C@H]2C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
CHEMBL1630941 63127 0 None 1 6 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 406 7 2 6 2.1 COc1ccc(C[C@@H](C)NC[C@H]2Oc3ccccc3O[C@H]2C)cc1S(N)(=O)=O 10.1016/j.ejmech.2010.09.042
11653915 130790 0 None -4 6 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 296 4 2 5 2.6 COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1 10.1016/j.bmcl.2005.07.083
CHEMBL362954 130790 0 None -4 6 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 296 4 2 5 2.6 COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1 10.1016/j.bmcl.2005.07.083
10893672 212191 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 357 6 1 7 1.3 COc1ccccc1N1CCN(CCNc2cc(C)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL80132 212191 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 357 6 1 7 1.3 COc1ccccc1N1CCN(CCNc2cc(C)nn(C)c2=O)CC1 10.1021/jm0009336
52941056 23895 0 None -2 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 363 11 1 4 4.3 c1ccc(COc2ccccc2OCCNCCOc2ccccc2)cc1 10.1016/j.bmc.2010.08.002
CHEMBL1255086 23895 0 None -2 4 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 363 11 1 4 4.3 c1ccc(COc2ccccc2OCCNCCOc2ccccc2)cc1 10.1016/j.bmc.2010.08.002
463 8187 22 None -50 13 Human 6.8 pKi = 6.8 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
6918097 8187 22 None -50 13 Human 6.8 pKi = 6.8 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
837 8187 22 None -50 13 Human 6.8 pKi = 6.8 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
CHEMBL2051956 8187 22 None -50 13 Human 6.8 pKi = 6.8 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
DB14068 8187 22 None -50 13 Human 6.8 pKi = 6.8 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00010a001
145948012 174503 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1cccc2c1S(=O)(=O)CCC2NCCOc1cc(F)ccc1F 10.1016/j.ejmech.2017.07.071
CHEMBL4209507 174503 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1cccc2c1S(=O)(=O)CCC2NCCOc1cc(F)ccc1F 10.1016/j.ejmech.2017.07.071
CHEMBL4302666 174503 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1cccc2c1S(=O)(=O)CCC2NCCOc1cc(F)ccc1F 10.1016/j.ejmech.2017.07.071
44460423 212395 0 None -11 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 446 7 0 6 4.3 O=C1CCCCN1Cc1cc(CN2CCN(c3ccccc3Oc3ccccc3)CC2)on1 10.1016/s0960-894x(02)00436-5
CHEMBL81661 212395 0 None -11 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 446 7 0 6 4.3 O=C1CCCCN1Cc1cc(CN2CCN(c3ccccc3Oc3ccccc3)CC2)on1 10.1016/s0960-894x(02)00436-5
44300166 203132 0 None -20 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 583 7 2 7 4.0 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCC(c4ccccn4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL56248 203132 0 None -20 3 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 583 7 2 7 4.0 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCC(c4ccccn4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
10721564 214129 0 None -223 3 Human 6.8 pKi = 6.8 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 558 7 1 5 4.9 COC(=O)N1C(=O)N(C)C(C)=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm990612y
CHEMBL93623 214129 0 None -223 3 Human 6.8 pKi = 6.8 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 558 7 1 5 4.9 COC(=O)N1C(=O)N(C)C(C)=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm990612y
10674791 44945 0 None -38 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 582 8 2 7 4.2 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(Cl)cc1 10.1021/jm990200p
CHEMBL146163 44945 0 None -38 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 582 8 2 7 4.2 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(Cl)cc1 10.1021/jm990200p
10578926 125744 0 None -85 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 1 7 4.5 COC(=O)C1=C(C)N=C(C)N(CCC[C@@H](C)CN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL342347 125744 0 None -85 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 1 7 4.5 COC(=O)C1=C(C)N=C(C)N(CCC[C@@H](C)CN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10816832 128282 0 None -489 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 1 7 4.5 COC(=O)C1=C(C)N=C(C)N(CCC[C@H](C)CN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL358313 128282 0 None -489 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 1 7 4.5 COC(=O)C1=C(C)N=C(C)N(CCC[C@H](C)CN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
43260 12254 65 None -1 5 Rat 5.8 pKi = 5.8 Binding
Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.5 - 1.9)Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.5 - 1.9)
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1021/jm025550h
CHEMBL1076 12254 65 None -1 5 Rat 5.8 pKi = 5.8 Binding
Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.5 - 1.9)Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.5 - 1.9)
ChEMBL 197 4 2 4 0.7 COc1ccc(OC)c(C(O)CN)c1 10.1021/jm025550h
44288754 177295 0 None -36 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 9 1 6 3.4 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C(C)c2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL44496 177295 0 None -36 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 9 1 6 3.4 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C(C)c2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(00)00307-3
10579368 112781 0 None -8 6 Human 5.8 pKi = 5.8 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 9 3 6 5.3 CC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL313251 112781 0 None -8 6 Human 5.8 pKi = 5.8 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 9 3 6 5.3 CC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
44312563 211699 2 None -144 7 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 401 7 1 8 1.0 COc1ccc(C)cc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 10.1021/jm960069a
CHEMBL76168 211699 2 None -144 7 Rat 6.8 pKi = 6.8 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 401 7 1 8 1.0 COc1ccc(C)cc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 10.1021/jm960069a
132060776 169181 0 None -6 16 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting method
ChEMBL 419 4 0 4 4.4 O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1 10.1016/j.ejmech.2018.02.024
CHEMBL4165863 169181 0 None -6 16 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting method
ChEMBL 419 4 0 4 4.4 O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1 10.1016/j.ejmech.2018.02.024
9844511 111373 0 None -85 3 Human 6.8 pKi = 6.8 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 411 7 1 5 3.0 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)n[nH]2)CC1 10.1016/s0960-894x(00)00472-8
CHEMBL310471 111373 0 None -85 3 Human 6.8 pKi = 6.8 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 411 7 1 5 3.0 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)n[nH]2)CC1 10.1016/s0960-894x(00)00472-8
155552821 183462 0 None -7 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 8 1 4 4.2 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)OC2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4544457 183462 0 None -7 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 8 1 4 4.2 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)OC2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4598345 183462 0 None -7 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 8 1 4 4.2 c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)OC2)cc1 10.1016/j.ejmech.2019.05.024
134132279 151852 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 351 8 1 6 2.7 COc1cccc(OC)c1OCCNCC1COC2(CCCCC2)O1 10.1016/j.ejmech.2016.09.050
CHEMBL3911497 151852 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 351 8 1 6 2.7 COc1cccc(OC)c1OCCNCC1COC2(CCCCC2)O1 10.1016/j.ejmech.2016.09.050
10836245 109524 0 None -58 5 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 427 7 0 5 4.4 CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)s2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL305029 109524 0 None -58 5 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 427 7 0 5 4.4 CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)s2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL552830 109524 0 None -58 5 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 427 7 0 5 4.4 CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)s2)CC1 10.1016/s0960-894x(02)00347-5
10415038 11211 0 None -6 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 545 6 1 7 5.3 Cc1noc(C)c1S(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3cccc4ccccc34)CC1)O2 10.1016/s0960-894x(98)00732-x
CHEMBL101610 11211 0 None -6 4 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 545 6 1 7 5.3 Cc1noc(C)c1S(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3cccc4ccccc34)CC1)O2 10.1016/s0960-894x(98)00732-x
9802999 202453 0 None 2 3 Rat 7.7 pKi = 7.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 434 5 0 6 3.1 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc([N+](=O)[O-])ccc2Cl)CC1 10.1021/jm030944+
CHEMBL55655 202453 0 None 2 3 Rat 7.7 pKi = 7.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 434 5 0 6 3.1 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc([N+](=O)[O-])ccc2Cl)CC1 10.1021/jm030944+
71817710 109184 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 355 7 1 6 3.3 COc1ccc2ccoc2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL2419770 109184 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 355 7 1 6 3.3 COc1ccc2ccoc2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL3039705 109184 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 355 7 1 6 3.3 COc1ccc2ccoc2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm400867d
71817859 109356 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 357 7 1 6 2.4 COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)OCC2 10.1021/jm400867d
CHEMBL2419772 109356 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 357 7 1 6 2.4 COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)OCC2 10.1021/jm400867d
CHEMBL3040801 109356 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 357 7 1 6 2.4 COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)OCC2 10.1021/jm400867d
11485631 169930 0 None -2 3 Rat 7.7 pKi = 7.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 374 8 0 5 2.7 COc1ccccc1OCCN(C)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
CHEMBL417939 169930 0 None -2 3 Rat 7.7 pKi = 7.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 374 8 0 5 2.7 COc1ccccc1OCCN(C)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
9959671 39445 0 None -371 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 0 7 5.6 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL141322 39445 0 None -371 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 0 7 5.6 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10841070 44453 0 None -380 4 Human 6.8 pKi = 6.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 585 10 0 5 7.4 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL145746 44453 0 None -380 4 Human 6.8 pKi = 6.8 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 585 10 0 5 7.4 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
44294957 197823 0 None -295 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 556 7 2 8 2.7 O=C1OCC2=C1C(c1ccc(F)c(F)c1)N(C(=O)NCCCN1CCN(c3ccccc3[N+](=O)[O-])CC1)C(=O)N2 10.1016/s0960-894x(99)00653-8
CHEMBL51871 197823 0 None -295 3 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 556 7 2 8 2.7 O=C1OCC2=C1C(c1ccc(F)c(F)c1)N(C(=O)NCCCN1CCN(c3ccccc3[N+](=O)[O-])CC1)C(=O)N2 10.1016/s0960-894x(99)00653-8
10722045 39589 0 None -891 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1F 10.1021/jm990200p
CHEMBL141444 39589 0 None -891 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1F 10.1021/jm990200p
10393665 40696 0 None -151 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 593 9 2 9 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
CHEMBL142383 40696 0 None -151 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 593 9 2 9 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
10555288 41514 0 None -162 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 582 8 2 7 4.2 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1cccc(Cl)c1 10.1021/jm990200p
CHEMBL143066 41514 0 None -162 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 582 8 2 7 4.2 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1cccc(Cl)c1 10.1021/jm990200p
10650633 44311 0 None -147 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 566 8 2 7 3.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1 10.1021/jm990200p
CHEMBL145610 44311 0 None -147 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 566 8 2 7 3.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1 10.1021/jm990200p
10675068 103225 0 None -891 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 599 9 2 7 3.9 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C#N)(c3cccc(F)c3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL262217 103225 0 None -891 3 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 599 9 2 7 3.9 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C#N)(c3cccc(F)c3)CC2)C(=O)N1 10.1021/jm990201h
44213782 17312 0 None -588 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 504 8 0 6 3.9 CCOC(=O)C1CN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CCC1c1ccccc1 10.1016/s0960-894x(98)00451-x
CHEMBL1169493 17312 0 None -588 3 Human 5.8 pKi = 5.8 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 504 8 0 6 3.9 CCOC(=O)C1CN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CCC1c1ccccc1 10.1016/s0960-894x(98)00451-x
10840781 43707 0 None -4 3 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 569 8 2 7 3.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(C(C)=O)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145122 43707 0 None -4 3 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 569 8 2 7 3.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(C(C)=O)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
53248365 68860 0 None -190 7 Human 6.7 pKi = 6.7 Binding
Inhibition of adrenergic Alpha-1D receptorInhibition of adrenergic Alpha-1D receptor
ChEMBL 554 6 1 5 2.9 O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I 10.1021/jm1009956
CHEMBL1774995 68860 0 None -190 7 Human 6.7 pKi = 6.7 Binding
Inhibition of adrenergic Alpha-1D receptorInhibition of adrenergic Alpha-1D receptor
ChEMBL 554 6 1 5 2.9 O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I 10.1021/jm1009956
11135150 14375 0 None -3 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 435 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
CHEMBL1087942 14375 0 None -3 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 435 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
CHEMBL287686 14375 0 None -3 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 435 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
76330200 92115 0 None -3 3 Rat 4.7 pKi = 4.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 323 3 2 5 1.2 CN(c1c(O)ccc2c1CCCC2C1=NCCN1)S(C)(=O)=O 10.1007/s00044-004-0020-z
CHEMBL2261354 92115 0 None -3 3 Rat 4.7 pKi = 4.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 323 3 2 5 1.2 CN(c1c(O)ccc2c1CCCC2C1=NCCN1)S(C)(=O)=O 10.1007/s00044-004-0020-z
1530 8963 50 None -104 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
3827 8963 50 None -104 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
7206 8963 50 None -104 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
CHEMBL534 8963 50 None -104 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
DB00920 8963 50 None -104 21 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 nan
489 6933 28 None -380 12 Rat 6.7 pKi = 6.7 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
5640 6933 28 None -380 12 Rat 6.7 pKi = 6.7 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
CHEMBL420060 6933 28 None -380 12 Rat 6.7 pKi = 6.7 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
76330198 92111 0 None -2 3 Rat 5.7 pKi = 5.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 337 5 3 5 2.0 CCCS(=O)(=O)Nc1c(O)ccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
CHEMBL2261348 92111 0 None -2 3 Rat 5.7 pKi = 5.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 337 5 3 5 2.0 CCCS(=O)(=O)Nc1c(O)ccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
10622206 108869 0 None -3 3 Rat 6.7 pKi = 6.7 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 423 6 1 6 3.6 COc1cc2c(cc1OC)NCN(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)C2 10.1021/jm000541z
CHEMBL302192 108869 0 None -3 3 Rat 6.7 pKi = 6.7 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 423 6 1 6 3.6 COc1cc2c(cc1OC)NCN(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)C2 10.1021/jm000541z
44431611 94356 0 None -6 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233582 94356 0 None -6 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
44431560 152356 0 None 2 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.008
CHEMBL391530 152356 0 None 2 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.008
56649650 74633 0 None -21 8 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 466 8 0 5 4.2 COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
CHEMBL1910141 74633 0 None -21 8 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 466 8 0 5 4.2 COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
10479323 41467 0 None -2 3 Human 7.7 pKi = 7.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 459 5 2 5 4.4 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccc(C(F)(F)F)cc1)C3 10.1021/jm030952q
CHEMBL143026 41467 0 None -2 3 Human 7.7 pKi = 7.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 459 5 2 5 4.4 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccc(C(F)(F)F)cc1)C3 10.1021/jm030952q
118716722 121794 0 None 1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 1 6 2.5 CCCCNC(=O)N1CCC2(CC1)OCC(CN1CCN(c3ccccc3OC)CC1)O2 10.1016/j.ejmech.2014.09.070
CHEMBL3342875 121794 0 None 1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 1 6 2.5 CCCCNC(=O)N1CCC2(CC1)OCC(CN1CCN(c3ccccc3OC)CC1)O2 10.1016/j.ejmech.2014.09.070
11395842 107467 0 None 6 3 Rat 7.7 pKi = 7.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 412 7 0 4 4.0 CN(CCOc1cc(Cl)ccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
CHEMBL292399 107467 0 None 6 3 Rat 7.7 pKi = 7.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 412 7 0 4 4.0 CN(CCOc1cc(Cl)ccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
2142 9870 58 None -5 37 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
4920903 9870 58 None -5 37 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
502 9870 58 None -5 37 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
5775 9870 58 None -5 37 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
CHEMBL597 9870 58 None -5 37 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
DB00692 9870 58 None -5 37 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1016/j.bmcl.2005.07.083
10602180 175760 0 None -5 3 Rat 7.7 pKi = 7.7 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 525 5 1 8 4.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncc(-c6ccccc6)nc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL43909 175760 0 None -5 3 Rat 7.7 pKi = 7.7 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 525 5 1 8 4.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncc(-c6ccccc6)nc54)c3=O)C[C@@H]21 10.1021/jm990567u
11762075 115279 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 445 4 2 5 3.3 CC(C)(C)c1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 10.1016/j.ejmech.2011.03.054
CHEMBL319972 115279 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 445 4 2 5 3.3 CC(C)(C)c1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 10.1016/j.ejmech.2011.03.054
44298694 107468 0 None -9 3 Human 7.7 pKi = 7.7 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 426 7 1 6 2.0 Cc1cn(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c(=O)[nH]c1=O 10.1016/s0960-894x(03)00305-6
CHEMBL292403 107468 0 None -9 3 Human 7.7 pKi = 7.7 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 426 7 1 6 2.0 Cc1cn(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c(=O)[nH]c1=O 10.1016/s0960-894x(03)00305-6
10507089 109105 0 None -186 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 560 9 2 7 3.3 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
CHEMBL303627 109105 0 None -186 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 560 9 2 7 3.3 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
10747201 43656 0 None -1905 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 618 10 3 8 2.3 COCC1=C(C(=O)OC)C(c2cc(F)c(F)cc2F)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 10.1021/jm990202+
CHEMBL145072 43656 0 None -1905 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 618 10 3 8 2.3 COCC1=C(C(=O)OC)C(c2cc(F)c(F)cc2F)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 10.1021/jm990202+
10531675 43555 0 None -100 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 602 8 2 5 5.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL144989 43555 0 None -100 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 602 8 2 5 5.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
11183468 116649 2 None -3 6 Rat 6.7 pKi = 6.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 213 1 2 2 2.5 Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL323402 116649 2 None -3 6 Rat 6.7 pKi = 6.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 213 1 2 2 2.5 Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
155524736 177769 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 368 5 0 5 3.0 COc1ccccc1N1CCN(C[C@H]2OCCO[C@H]2c2ccccc2)CC1 10.1016/j.ejmech.2019.02.056
CHEMBL4456257 177769 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 368 5 0 5 3.0 COc1ccccc1N1CCN(C[C@H]2OCCO[C@H]2c2ccccc2)CC1 10.1016/j.ejmech.2019.02.056
11183468 116649 2 None -3 6 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 213 1 2 2 2.5 Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL323402 116649 2 None -3 6 Rat 6.7 pKi = 6.7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 213 1 2 2 2.5 Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
10745566 41092 0 None -134 3 Human 5.7 pKi = 5.7 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 566 10 1 6 5.1 CNC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1F 10.1021/jm9902032
CHEMBL142719 41092 0 None -134 3 Human 5.7 pKi = 5.7 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 566 10 1 6 5.1 CNC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1F 10.1021/jm9902032
44295193 108555 0 None -54 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 576 7 2 9 2.6 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc3c(c2)OCO3)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL299984 108555 0 None -54 3 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 576 7 2 9 2.6 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc3c(c2)OCO3)CC1 10.1016/s0960-894x(99)00653-8
11449200 85236 0 None -20 3 Rat 5.7 pKi = 5.7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCC[C@H]2c1c[nH]cn1 10.1021/jm030551a
CHEMBL2111710 85236 0 None -20 3 Rat 5.7 pKi = 5.7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 291 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCC[C@H]2c1c[nH]cn1 10.1021/jm030551a
487 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00019a001
60602 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00019a001
CHEMBL405355 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00019a001
DB09239 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm00019a001
10320782 106753 0 None -22 7 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 435 9 1 6 4.6 COc1cccc(OC)c1OCCNC[C@H]1Oc2ccccc2O[C@@H]1c1ccc(C)cc1 10.1021/jm960069a
CHEMBL286565 106753 0 None -22 7 Rat 6.7 pKi = 6.7 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 435 9 1 6 4.6 COc1cccc(OC)c1OCCNC[C@H]1Oc2ccccc2O[C@@H]1c1ccc(C)cc1 10.1021/jm960069a
53779053 85212 0 None -15 3 Human 6.7 pKi = 6.7 Binding
Tested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assayTested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assay
ChEMBL 475 6 1 4 5.0 C[C@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H]1c1ccc(F)c(F)c1 10.1016/s0960-894x(00)00524-2
CHEMBL2111563 85212 0 None -15 3 Human 6.7 pKi = 6.7 Binding
Tested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assayTested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assay
ChEMBL 475 6 1 4 5.0 C[C@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H]1c1ccc(F)c(F)c1 10.1016/s0960-894x(00)00524-2
10721730 44267 0 None -245 3 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 568 6 2 7 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)OC(=O)c2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL145571 44267 0 None -245 3 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 568 6 2 7 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)OC(=O)c2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
4011 89183 49 None -19 24 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 nan
CHEMBL21731 89183 49 None -19 24 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 nan
11488170 42004 0 None -5 3 Human 6.7 pKi = 6.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 467 10 2 8 3.6 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNCCOc1c(OC)cccc1OC)C3 10.1021/jm030952q
CHEMBL143558 42004 0 None -5 3 Human 6.7 pKi = 6.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 467 10 2 8 3.6 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNCCOc1c(OC)cccc1OC)C3 10.1021/jm030952q
11152823 172038 0 None -2 3 Human 6.7 pKi = 6.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 367 5 2 6 2.6 COc1cc2nc3c(c(N)c2cc1OC)CC(CNC(=O)c1ccco1)C3 10.1021/jm030952q
CHEMBL423018 172038 0 None -2 3 Human 6.7 pKi = 6.7 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 367 5 2 6 2.6 COc1cc2nc3c(c(N)c2cc1OC)CC(CNC(=O)c1ccco1)C3 10.1021/jm030952q
10640982 33207 0 None -239 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 341 5 2 5 2.4 O[C@H]1[C@@H](NC[C@H]2COc3ccccc3O2)CC[C@@H]1Oc1ccccc1 10.1021/jm991065j
CHEMBL135974 33207 0 None -239 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 341 5 2 5 2.4 O[C@H]1[C@@H](NC[C@H]2COc3ccccc3O2)CC[C@@H]1Oc1ccccc1 10.1021/jm991065j
44531812 201461 0 None -10 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 374 7 2 6 4.3 COc1cccc2c(NCCNc3ccnc4c(OC)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
CHEMBL532818 201461 0 None -10 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 374 7 2 6 4.3 COc1cccc2c(NCCNc3ccnc4c(OC)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
44531812 201461 0 None -10 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 374 7 2 6 4.3 COc1cccc2c(NCCNc3ccnc4c(OC)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
CHEMBL532818 201461 0 None -10 4 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 374 7 2 6 4.3 COc1cccc2c(NCCNc3ccnc4c(OC)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
3584 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/s0960-894x(98)00446-6
5401 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/s0960-894x(98)00446-6
7302 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/s0960-894x(98)00446-6
CHEMBL611 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/s0960-894x(98)00446-6
DB01162 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1016/s0960-894x(98)00446-6
11519153 92524 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 514 9 1 6 4.7 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
11519153 92524 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 514 9 1 6 4.7 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL229085 92524 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 514 9 1 6 4.7 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL229085 92524 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 514 9 1 6 4.7 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
3584 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
5401 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
7302 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
CHEMBL611 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
DB01162 10549 64 None -1 14 Human 8.7 pKi = 8.7 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
9826801 114714 0 None -8 12 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 488 6 1 7 3.2 Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
CHEMBL319352 114714 0 None -8 12 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 488 6 1 7 3.2 Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
9826801 114714 0 None -8 12 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 488 6 1 7 3.2 Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1016/j.bmc.2012.10.049
CHEMBL319352 114714 0 None -8 12 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 488 6 1 7 3.2 Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1016/j.bmc.2012.10.049
9826801 114714 0 None -8 12 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 488 6 1 7 3.2 Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm100652h
CHEMBL319352 114714 0 None -8 12 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 488 6 1 7 3.2 Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm100652h
12840735 204775 0 None -1 3 Rat 8.7 pKi = 8.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 389 4 0 4 3.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm030944+
CHEMBL57364 204775 0 None -1 3 Rat 8.7 pKi = 8.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 389 4 0 4 3.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cccc(Cl)c2)CC1 10.1021/jm030944+
10478895 107003 0 None -2 3 Rat 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 449 4 1 8 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5nccnc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL288530 107003 0 None -2 3 Rat 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 449 4 1 8 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5nccnc54)c3=O)C[C@@H]21 10.1021/jm990567u
10718348 107021 0 None -3 3 Rat 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 449 4 1 8 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncncc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL288678 107021 0 None -3 3 Rat 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 449 4 1 8 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncncc54)c3=O)C[C@@H]21 10.1021/jm990567u
10839389 107130 0 None 3 3 Rat 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 472 4 1 7 3.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5c(C#N)cccc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL289627 107130 0 None 3 3 Rat 8.7 pKi = 8.7 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 472 4 1 7 3.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5c(C#N)cccc54)c3=O)C[C@@H]21 10.1021/jm990567u
44431557 96053 0 None 8 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 541 8 1 6 4.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL236830 96053 0 None 8 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 541 8 1 6 4.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
11857711 92396 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 506 7 1 4 5.5 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.098
CHEMBL228280 92396 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 506 7 1 4 5.5 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.098
10487999 66172 5 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1ccsc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL1237160 66172 5 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1ccsc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL170960 66172 5 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1ccsc1C(C)c1c[nH]cn1 10.1021/jm0003891
145962478 169028 0 None -4 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 459 5 2 9 2.8 COc1cc2nc(N3CCC[C@H](NC4=CC(=O)c5ccccc5C4=O)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
CHEMBL4163587 169028 0 None -4 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 459 5 2 9 2.8 COc1cc2nc(N3CCC[C@H](NC4=CC(=O)c5ccccc5C4=O)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
11474152 107397 0 None 11 4 Rat 8.7 pKi = 8.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 369 4 0 4 2.8 Cc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL291908 107397 0 None 11 4 Rat 8.7 pKi = 8.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 369 4 0 4 2.8 Cc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
44431594 174189 0 None 1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 532 9 1 8 3.8 COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL429623 174189 0 None 1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 532 9 1 8 3.8 COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
11857709 92403 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 556 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
11857709 92403 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 556 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL228334 92403 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 556 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL228334 92403 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 556 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
9932835 107570 0 None 23 4 Rat 8.7 pKi = 8.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 437 4 0 4 4.2 O=C1CC2(CCCCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL293111 107570 0 None 23 4 Rat 8.7 pKi = 8.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 437 4 0 4 4.2 O=C1CC2(CCCCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
71817547 109355 0 None -8 7 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 357 7 1 6 2.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)OCC2 10.1021/jm400867d
CHEMBL2419771 109355 0 None -8 7 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 357 7 1 6 2.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)OCC2 10.1021/jm400867d
CHEMBL3040800 109355 0 None -8 7 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 357 7 1 6 2.4 COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)OCC2 10.1021/jm400867d
145962945 168122 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 511 5 1 7 4.6 COc1cc2nc(N3CCN(C(=O)Cc4ccc5ccccc5c4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4125846 168122 0 None -1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 511 5 1 7 4.6 COc1cc2nc(N3CCN(C(=O)Cc4ccc5ccccc5c4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
90645606 119216 0 None -2 3 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 652 12 2 9 4.8 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCNC(=O)Cc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298024 119216 0 None -2 3 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 652 12 2 9 4.8 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCNC(=O)Cc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
10679310 65988 1 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1sccc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL170201 65988 1 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1sccc1C(C)c1c[nH]cn1 10.1021/jm0003891
CHEMBL1744269 65988 1 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 192 2 1 2 2.9 Cc1sccc1C(C)c1c[nH]cn1 10.1021/jm0003891
10647790 108168 0 None -4 3 Rat 8.6 pKi = 8.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 463 4 1 8 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5nc(C)cnc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL297218 108168 0 None -4 3 Rat 8.6 pKi = 8.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 463 4 1 8 2.7 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5nc(C)cnc54)c3=O)C[C@@H]21 10.1021/jm990567u
44428848 99069 0 None -9 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 453 4 1 8 3.6 COc1cc2nc(N3CCN(C(=O)c4cccs4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL242724 99069 0 None -9 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 453 4 1 8 3.6 COc1cc2nc(N3CCN(C(=O)c4cccs4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
9908283 205715 0 None 21 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 387 4 0 4 3.0 Cc1ccc(F)c(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c1 10.1021/jm030944+
CHEMBL58476 205715 0 None 21 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 387 4 0 4 3.0 Cc1ccc(F)c(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c1 10.1021/jm030944+
44431547 161383 0 None 2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL399195 161383 0 None 2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
2419 7482 28 None -3 11 Rat 8.6 pKi = 8.6 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm980053f
9 7482 28 None -3 11 Rat 8.6 pKi = 8.6 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm980053f
CHEMBL13647 7482 28 None -3 11 Rat 8.6 pKi = 8.6 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm980053f
44431548 93821 0 None 2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 502 8 1 7 3.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3[N+](=O)[O-])CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL232592 93821 0 None 2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 502 8 1 7 3.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3[N+](=O)[O-])CC2)CC1 10.1016/j.bmcl.2007.04.008
10582623 108545 0 None 1 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 392 4 1 6 1.8 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cccnc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL299907 108545 0 None 1 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 392 4 1 6 1.8 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cccnc4c3=O)C[C@@H]21 10.1021/jm000541z
52942395 24693 0 None -4 6 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 386 3 0 4 5.0 CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 10.1016/j.bmc.2012.10.049
CHEMBL1259203 24693 0 None -4 6 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 386 3 0 4 5.0 CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 10.1016/j.bmc.2012.10.049
52942395 24693 0 None -4 6 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 386 3 0 4 5.0 CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 10.1021/jm100652h
CHEMBL1259203 24693 0 None -4 6 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 386 3 0 4 5.0 CN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4cncnc4)cc23)CC1 10.1021/jm100652h
148842 10718 27 None -8 5 Human 8.6 pKi = 8.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 511 8 1 6 4.7 COc1ccccc1N1CCN(CC1)CCCNC(=O)c1cccc2c1oc(c1ccccc1)c(c2=O)C 10.1021/jm960697s
496 10718 27 None -8 5 Human 8.6 pKi = 8.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 511 8 1 6 4.7 COc1ccccc1N1CCN(CC1)CCCNC(=O)c1cccc2c1oc(c1ccccc1)c(c2=O)C 10.1021/jm960697s
CHEMBL278865 10718 27 None -8 5 Human 8.6 pKi = 8.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 511 8 1 6 4.7 COc1ccccc1N1CCN(CC1)CCCNC(=O)c1cccc2c1oc(c1ccccc1)c(c2=O)C 10.1021/jm960697s
9909211 100983 1 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 404 8 2 7 1.9 COc1ccc(Cl)cc1N1CCN(CCCNc2nccc(C(N)=O)n2)CC1 10.1021/jm960697s
CHEMBL24981 100983 1 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 404 8 2 7 1.9 COc1ccc(Cl)cc1N1CCN(CCCNc2nccc(C(N)=O)n2)CC1 10.1021/jm960697s
46934641 23450 0 None 2 4 Human 8.6 pKi = 8.6 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 479 7 0 6 3.5 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3CCCCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242633 23450 0 None 2 4 Human 8.6 pKi = 8.6 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 479 7 0 6 3.5 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3CCCCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
44298447 107576 0 None -5 3 Human 8.6 pKi = 8.6 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 430 6 1 6 1.7 Cc1c[nH]c(=O)n(CCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
CHEMBL293149 107576 0 None -5 3 Human 8.6 pKi = 8.6 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 430 6 1 6 1.7 Cc1c[nH]c(=O)n(CCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
134147929 156420 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 340 7 0 4 3.5 CCOc1ccccc1N1CCN(CCc2cccc(OC)c2)CC1 10.1016/j.ejmech.2016.06.052
CHEMBL3947302 156420 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 340 7 0 4 3.5 CCOc1ccccc1N1CCN(CCc2cccc(OC)c2)CC1 10.1016/j.ejmech.2016.06.052
11857710 149141 0 None -1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 518 8 1 5 5.4 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1 10.1016/j.bmcl.2007.04.098
CHEMBL388897 149141 0 None -1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 518 8 1 5 5.4 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1 10.1016/j.bmcl.2007.04.098
25025048 146824 1 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 295 3 2 3 2.4 N=c1c(C(N)=O)cc(Cl)cn1Cc1cccc(Cl)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3800305 146824 1 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 295 3 2 3 2.4 N=c1c(C(N)=O)cc(Cl)cn1Cc1cccc(Cl)c1 10.1021/acs.jmedchem.5b01528
16041265 102112 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL256597 102112 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
9822812 202651 0 None 30 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 409 4 0 4 3.4 O=C1CC2(CCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL55882 202651 0 None 30 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 409 4 0 4 3.4 O=C1CC2(CCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
44426405 148831 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 562 9 1 5 5.7 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc(OC(F)F)cc1 10.1016/j.bmcl.2007.04.098
CHEMBL387832 148831 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 562 9 1 5 5.7 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc(OC(F)F)cc1 10.1016/j.bmcl.2007.04.098
16041451 104584 0 None -1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL271913 104584 0 None -1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.11.068
16041628 162129 0 None -1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL403280 162129 0 None -1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
10917953 214767 0 None -7 10 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 489 6 0 8 3.6 Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
CHEMBL97242 214767 0 None -7 10 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 489 6 0 8 3.6 Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
10742417 209552 0 None -1 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 455 5 1 6 3.0 COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1Cl 10.1021/jm000541z
CHEMBL62109 209552 0 None -1 3 Rat 8.6 pKi = 8.6 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 455 5 1 6 3.0 COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1Cl 10.1021/jm000541z
52945156 23830 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 455 13 1 6 4.1 COc1cccc(OC)c1[S+]([O-])CCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1254660 23830 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 455 13 1 6 4.1 COc1cccc(OC)c1[S+]([O-])CCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
49781233 24697 0 None -41 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 392 2 0 7 2.9 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4nnnn4C)cc32)CC1 10.1021/jm100652h
CHEMBL1259217 24697 0 None -41 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 392 2 0 7 2.9 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4nnnn4C)cc32)CC1 10.1021/jm100652h
10554492 175346 0 None 1 3 Rat 8.6 pKi = 8.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 505 5 1 8 3.4 COC(=O)c1ccc2sc3c(=O)n(CCN4C[C@@H]5CCc6c(OC)cccc6[C@@H]5C4)c(=O)[nH]c3c2c1 10.1021/jm990567u
CHEMBL43573 175346 0 None 1 3 Rat 8.6 pKi = 8.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 505 5 1 8 3.4 COC(=O)c1ccc2sc3c(=O)n(CCN4C[C@@H]5CCc6c(OC)cccc6[C@@H]5C4)c(=O)[nH]c3c2c1 10.1021/jm990567u
10716964 107368 0 None -1 3 Rat 8.5 pKi = 8.5 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 419 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)cc(C)cc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL291769 107368 0 None -1 3 Rat 8.5 pKi = 8.5 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 419 4 1 5 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)cc(C)cc4c3=O)C[C@@H]21 10.1021/jm000541z
10810527 107349 0 None 2 3 Rat 8.5 pKi = 8.5 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 392 4 1 6 1.8 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ccncc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL291588 107349 0 None 2 3 Rat 8.5 pKi = 8.5 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 392 4 1 6 1.8 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ccncc4c3=O)C[C@@H]21 10.1021/jm000541z
11315660 174767 0 None 6 4 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 403 4 0 4 3.6 O=C1CC2(CCCCC2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 10.1021/jm030944+
CHEMBL431943 174767 0 None 6 4 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 403 4 0 4 3.6 O=C1CC2(CCCCC2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 10.1021/jm030944+
100 10577 58 None -1 54 Human 8.5 pKi = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
2637 10577 58 None -1 54 Human 8.5 pKi = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
5452 10577 58 None -1 54 Human 8.5 pKi = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
CHEMBL479 10577 58 None -1 54 Human 8.5 pKi = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
DB00679 10577 58 None -1 54 Human 8.5 pKi = 8.5 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 nan
11154198 208393 0 None -5 5 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 413 6 0 5 3.3 CC(C)Oc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL60583 208393 0 None -5 5 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 413 6 0 5 3.3 CC(C)Oc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
52946023 24686 0 None -4 6 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 477 7 2 4 3.6 CC(=O)NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 10.1021/jm100652h
CHEMBL1259187 24686 0 None -4 6 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 477 7 2 4 3.6 CC(=O)NCc1ccc2c(c1)c(C1CCN(CCN3CCNC3=O)CC1)cn2-c1ccc(F)cc1 10.1021/jm100652h
9822477 206231 0 None 23 5 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 403 4 0 4 3.5 Cc1ccc(Cl)c(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c1 10.1021/jm030944+
CHEMBL59149 206231 0 None 23 5 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 403 4 0 4 3.5 Cc1ccc(Cl)c(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c1 10.1021/jm030944+
11081136 212005 0 None -1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 467 8 1 7 3.7 COc1ccc(Cl)cc1N1CCN(CCCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL78676 212005 0 None -1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 467 8 1 7 3.7 COc1ccc(Cl)cc1N1CCN(CCCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
1588 9105 27 None -20 44 Human 7.7 pKi = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
28864 9105 27 None -20 44 Human 7.7 pKi = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
43 9105 27 None -20 44 Human 7.7 pKi = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
CHEMBL157138 9105 27 None -20 44 Human 7.7 pKi = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
DB00589 9105 27 None -20 44 Human 7.7 pKi = 7.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC nan
16041090 102168 0 None 1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 10.1016/j.bmcl.2007.11.068
CHEMBL256853 102168 0 None 1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 10.1016/j.bmcl.2007.11.068
10310103 114089 0 None -5 9 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 425 5 0 5 5.3 N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 10.1021/jm020938y
CHEMBL317333 114089 0 None -5 9 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 425 5 0 5 5.3 N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 10.1021/jm020938y
10394346 23735 0 None -16 5 Human 7.7 pKi = 7.7 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 638 11 2 10 3.0 Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C(N)=O)CC3)cccc2c1=O 10.1021/jm030825u
CHEMBL125365 23735 0 None -16 5 Human 7.7 pKi = 7.7 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 638 11 2 10 3.0 Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C(N)=O)CC3)cccc2c1=O 10.1021/jm030825u
46881382 14096 0 None -158 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 437 9 1 5 5.4 COc1ccccc1OCCNCC1CSC(c2ccccc2)(c2ccccc2)S1 10.1016/j.bmcl.2010.01.030
CHEMBL1086156 14096 0 None -158 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 437 9 1 5 5.4 COc1ccccc1OCCNCC1CSC(c2ccccc2)(c2ccccc2)S1 10.1016/j.bmcl.2010.01.030
118716706 121777 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 451 5 0 6 2.9 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342859 121777 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 451 5 0 6 2.9 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
56961507 128220 0 None -4 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 678 6 4 11 5.0 COc1cc2nc(N3CCN(C(=S)Nc4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)CC3)nc(N)c2cc1OC 10.1021/ml5004298
CHEMBL3582271 128220 0 None -4 3 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 678 6 4 11 5.0 COc1cc2nc(N3CCN(C(=S)Nc4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)CC3)nc(N)c2cc1OC 10.1021/ml5004298
10649481 213597 0 None -1230 3 Human 6.7 pKi = 6.7 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 514 7 1 3 4.8 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N(C)C(=O)N1C 10.1021/jm990612y
CHEMBL90420 213597 0 None -1230 3 Human 6.7 pKi = 6.7 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 514 7 1 3 4.8 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N(C)C(=O)N1C 10.1021/jm990612y
44331079 11090 0 None -3 3 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 355 3 0 2 5.3 C1=CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccccc21 10.1016/s0960-894x(98)00732-x
CHEMBL100878 11090 0 None -3 3 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 355 3 0 2 5.3 C1=CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccccc21 10.1016/s0960-894x(98)00732-x
44462130 212111 0 None -45 3 Human 5.7 pKi = 5.7 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 490 7 0 6 3.5 COC(=O)C1(c2ccccc2)CCN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC1 10.1016/s0960-894x(98)00451-x
CHEMBL79532 212111 0 None -45 3 Human 5.7 pKi = 5.7 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 490 7 0 6 3.5 COC(=O)C1(c2ccccc2)CCN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC1 10.1016/s0960-894x(98)00451-x
118717456 121914 0 None -4 4 Human 6.7 pKi = 6.7 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 342 5 2 4 4.9 Cc1ccc2c(NCCNc3ccnc4cc(C)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343977 121914 0 None -4 4 Human 6.7 pKi = 6.7 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 342 5 2 4 4.9 Cc1ccc2c(NCCNc3ccnc4cc(C)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
9895338 101220 0 None -309 3 Human 6.7 pKi = 6.7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 622 11 2 7 6.8 CCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)/C(=C(\O)OC)C(C)=N1 10.1021/jm960697s
CHEMBL25121 101220 0 None -309 3 Human 6.7 pKi = 6.7 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 622 11 2 7 6.8 CCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)/C(=C(\O)OC)C(C)=N1 10.1021/jm960697s
118717456 121914 0 None -4 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 342 5 2 4 4.9 Cc1ccc2c(NCCNc3ccnc4cc(C)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343977 121914 0 None -4 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 342 5 2 4 4.9 Cc1ccc2c(NCCNc3ccnc4cc(C)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
44417715 18610 0 None -2 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 399 8 1 6 3.4 COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL1182160 18610 0 None -2 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 399 8 1 6 3.4 COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL215857 18610 0 None -2 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 399 8 1 6 3.4 COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
11301627 16170 0 None -1 2 Rat 5.7 pKi = 5.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 319 4 2 3 3.0 CC(C)S(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL111537 16170 0 None -1 2 Rat 5.7 pKi = 5.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 319 4 2 3 3.0 CC(C)S(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
11301627 16170 0 None -1 2 Rat 5.7 pKi = 5.7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 319 4 2 3 3.0 CC(C)S(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL111537 16170 0 None -1 2 Rat 5.7 pKi = 5.7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 319 4 2 3 3.0 CC(C)S(=O)(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
11429464 107788 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 398 7 1 4 3.7 O=C1CC2(CCCC2)CC(=O)N1CCNCCOc1cc(Cl)ccc1Cl 10.1021/jm030944+
CHEMBL294479 107788 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 398 7 1 4 3.7 O=C1CC2(CCCC2)CC(=O)N1CCNCCOc1cc(Cl)ccc1Cl 10.1021/jm030944+
136806218 119455 0 None -331 3 Human 5.7 pKi = 5.7 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 682 15 4 9 3.9 COc1ccc(C2(c3ccccc3)CCN(CCCNC(=O)C3=C(COCCN)NC(C)=C(C(N)=O)C3c3ccc([N+](=O)[O-])cc3)CC2)cc1 10.1016/s0960-894x(99)00484-9
44328754 119455 0 None -331 3 Human 5.7 pKi = 5.7 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 682 15 4 9 3.9 COc1ccc(C2(c3ccccc3)CCN(CCCNC(=O)C3=C(COCCN)NC(C)=C(C(N)=O)C3c3ccc([N+](=O)[O-])cc3)CC2)cc1 10.1016/s0960-894x(99)00484-9
CHEMBL330401 119455 0 None -331 3 Human 5.7 pKi = 5.7 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 682 15 4 9 3.9 COc1ccc(C2(c3ccccc3)CCN(CCCNC(=O)C3=C(COCCN)NC(C)=C(C(N)=O)C3c3ccc([N+](=O)[O-])cc3)CC2)cc1 10.1016/s0960-894x(99)00484-9
489 6933 28 None -34 12 Human 7.7 pKi = 7.7 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
5640 6933 28 None -34 12 Human 7.7 pKi = 7.7 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
CHEMBL420060 6933 28 None -34 12 Human 7.7 pKi = 7.7 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
10554140 125895 0 None -104 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 527 7 2 6 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL342731 125895 0 None -104 3 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 527 7 2 6 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
2470 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm960510x
3300 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm960510x
5265 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm960510x
99 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm960510x
CHEMBL267930 10425 50 None -389 58 Rat 7.7 pKi = 7.7 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1021/jm960510x
9960497 107252 0 None -645 6 Human 6.7 pKi = 6.7 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.9 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
CHEMBL290860 107252 0 None -645 6 Human 6.7 pKi = 6.7 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.9 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
19085894 212338 0 None -87 3 Human 6.7 pKi = 6.7 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in COS-7 cellsAbility to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in COS-7 cells
ChEMBL 533 7 0 9 2.3 CS(=O)(=O)c1ccc2c(c1)S(=O)(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)C2=O 10.1016/s0960-894x(98)00446-6
CHEMBL81173 212338 0 None -87 3 Human 6.7 pKi = 6.7 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in COS-7 cellsAbility to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in COS-7 cells
ChEMBL 533 7 0 9 2.3 CS(=O)(=O)c1ccc2c(c1)S(=O)(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)C2=O 10.1016/s0960-894x(98)00446-6
10721476 43773 0 None -691 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 554 6 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)OCc2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL145170 43773 0 None -691 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 554 6 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)OCc2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
44362633 128325 0 None -138 3 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 597 9 3 6 3.9 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCC(C)N2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL358590 128325 0 None -138 3 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 597 9 3 6 3.9 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCC(C)N2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
10026936 170237 0 None -204 3 Human 5.7 pKi = 5.7 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 8 1 3 5.1 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(F)c(F)c2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL41994 170237 0 None -204 3 Human 5.7 pKi = 5.7 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 8 1 3 5.1 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(F)c(F)c2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
118717457 121915 0 None -4 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 374 7 2 6 4.3 COc1ccc2c(NCCNc3ccnc4cc(OC)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343978 121915 0 None -4 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 374 7 2 6 4.3 COc1ccc2c(NCCNc3ccnc4cc(OC)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
11994915 18604 0 None -2 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cc(-c2ccccc2)ccc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182145 18604 0 None -2 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cc(-c2ccccc2)ccc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL214762 18604 0 None -2 7 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cc(-c2ccccc2)ccc1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
134153527 159216 0 None -9 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 307 6 1 4 3.4 c1ccc(OCCNCC2CSC3(CCCCC3)O2)cc1 10.1016/j.ejmech.2016.09.050
CHEMBL3970754 159216 0 None -9 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 307 6 1 4 3.4 c1ccc(OCCNCC2CSC3(CCCCC3)O2)cc1 10.1016/j.ejmech.2016.09.050
9922027 122188 0 None -1 3 Rat 5.7 pKi = 5.7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 289 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCC=C2c1c[nH]cn1 10.1021/jm030551a
CHEMBL3350265 122188 0 None -1 3 Rat 5.7 pKi = 5.7 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 289 3 2 3 2.2 CS(=O)(=O)Nc1cccc2c1CCC=C2c1c[nH]cn1 10.1021/jm030551a
118717457 121915 0 None -4 4 Human 6.7 pKi = 6.7 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 374 7 2 6 4.3 COc1ccc2c(NCCNc3ccnc4cc(OC)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343978 121915 0 None -4 4 Human 6.7 pKi = 6.7 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 374 7 2 6 4.3 COc1ccc2c(NCCNc3ccnc4cc(OC)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
10791844 213936 0 None -1258 3 Human 6.7 pKi = 6.7 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 511 7 3 4 4.0 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
CHEMBL92328 213936 0 None -1258 3 Human 6.7 pKi = 6.7 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 511 7 3 4 4.0 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
76315668 92110 0 None -36 3 Rat 5.7 pKi = 5.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 323 4 3 5 1.6 CCS(=O)(=O)Nc1c(O)ccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
CHEMBL2261347 92110 0 None -36 3 Rat 5.7 pKi = 5.7 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 323 4 3 5 1.6 CCS(=O)(=O)Nc1c(O)ccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
9798183 19912 0 None -34 3 Human 7.7 pKi = 7.7 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 343 5 1 2 4.4 Fc1ccc2c(C3CCN(CCCN4CCCCC4)CC3)c[nH]c2c1 10.1016/j.bmcl.2006.05.002
CHEMBL1190579 19912 0 None -34 3 Human 7.7 pKi = 7.7 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 343 5 1 2 4.4 Fc1ccc2c(C3CCN(CCCN4CCCCC4)CC3)c[nH]c2c1 10.1016/j.bmcl.2006.05.002
CHEMBL541129 19912 0 None -34 3 Human 7.7 pKi = 7.7 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 343 5 1 2 4.4 Fc1ccc2c(C3CCN(CCCN4CCCCC4)CC3)c[nH]c2c1 10.1016/j.bmcl.2006.05.002
44431594 94794 0 None -21 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 532 9 1 8 3.8 COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234422 94794 0 None -21 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 532 9 1 8 3.8 COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
44431555 95938 0 None -2 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 535 8 1 7 3.3 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(S(C)(=O)=O)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL236618 95938 0 None -2 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 535 8 1 7 3.3 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(S(C)(=O)=O)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
44433348 174128 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 545 10 0 7 4.6 CCN([C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1)S(=O)(=O)c1ccc(OC)c(OC)c1 10.1016/j.bmcl.2007.09.051
CHEMBL429453 174128 0 None -1 4 Human 7.7 pKi = 7.7 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 545 10 0 7 4.6 CCN([C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1)S(=O)(=O)c1ccc(OC)c(OC)c1 10.1016/j.bmcl.2007.09.051
10506729 210478 0 None -53 3 Human 7.7 pKi = 7.7 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 544 9 1 6 4.4 CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
CHEMBL67552 210478 0 None -53 3 Human 7.7 pKi = 7.7 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 544 9 1 6 4.4 CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
1960 9632 67 None -21 26 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
439260 9632 67 None -21 26 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
505 9632 67 None -21 26 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
CHEMBL1437 9632 67 None -21 26 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
DB00368 9632 67 None -21 26 Rat 7.7 pKi = 7.7 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 10.1021/jm960354u
44417713 19194 0 None -4 8 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1185884 19194 0 None -4 8 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL439346 19194 0 None -4 8 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
11133868 162121 0 None -9 7 Human 7.6 pKi = 7.6 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 435 9 1 5 5.4 COc1cccc(OC)c1OCCNC[C@H]1C[C@H](c2ccccc2)c2ccccc2S1 10.1021/jm011066n
CHEMBL40325 162121 0 None -9 7 Human 7.6 pKi = 7.6 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 435 9 1 5 5.4 COc1cccc(OC)c1OCCNC[C@H]1C[C@H](c2ccccc2)c2ccccc2S1 10.1021/jm011066n
127040157 143705 0 None -7 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL3739897 143705 0 None -7 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
CHEMBL3742490 143705 0 None -7 5 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
ChEMBL 375 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1039/C4MD00484A
118716705 121776 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 424 5 0 7 2.6 COc1ccccc1N1CCN(CC2COC3(CCN(c4ccccn4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342858 121776 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 424 5 0 7 2.6 COc1ccccc1N1CCN(CC2COC3(CCN(c4ccccn4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
10815549 128792 0 None -549 3 Human 6.7 pKi = 6.7 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 509 9 0 5 6.2 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL359421 128792 0 None -549 3 Human 6.7 pKi = 6.7 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 509 9 0 5 6.2 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
11800744 214110 0 None -10 3 Human 6.7 pKi = 6.7 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 547 7 3 4 4.4 N#Cc1ccccc1C1CCN(CCCNC(=O)C2=C(C(F)(F)F)NC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
CHEMBL93523 214110 0 None -10 3 Human 6.7 pKi = 6.7 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 547 7 3 4 4.4 N#Cc1ccccc1C1CCN(CCCNC(=O)C2=C(C(F)(F)F)NC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
10507129 128751 0 None -27 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 562 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(C)cc1 10.1021/jm990200p
CHEMBL359173 128751 0 None -27 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 562 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(C)cc1 10.1021/jm990200p
10414908 209543 0 None -457 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 539 7 0 4 5.9 Cc1ccc(C2(c3ccc(C)cc3)CC(=O)N(CCCN3CCC(C#N)(c4ccccc4Cl)CC3)C2=O)cc1 10.1016/s0960-894x(01)00320-1
CHEMBL62045 209543 0 None -457 3 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 539 7 0 4 5.9 Cc1ccc(C2(c3ccc(C)cc3)CC(=O)N(CCCN3CCC(C#N)(c4ccccc4Cl)CC3)C2=O)cc1 10.1016/s0960-894x(01)00320-1
10839825 213520 0 None -5623 3 Human 5.7 pKi = 5.7 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 525 7 2 4 4.1 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1C 10.1021/jm990612y
CHEMBL89965 213520 0 None -5623 3 Human 5.7 pKi = 5.7 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 525 7 2 4 4.1 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1C 10.1021/jm990612y
1028 7079 71 None -17 30 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
139148732 7079 71 None -17 30 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
479 7079 71 None -17 30 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
5816 7079 71 None -17 30 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
CHEMBL679 7079 71 None -17 30 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
DB00668 7079 71 None -17 30 Human 6.7 pKi = 6.7 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O nan
10859076 20454 0 None -3 6 Human 6.7 pKi = 6.7 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1194763 20454 0 None -3 6 Human 6.7 pKi = 6.7 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL553276 20454 0 None -3 6 Human 6.7 pKi = 6.7 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1 10.1021/jm000542r
9894818 105701 0 None -138 7 Human 6.7 pKi = 6.7 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL279436 105701 0 None -138 7 Human 6.7 pKi = 6.7 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
10221004 211010 0 None -2 5 Human 5.7 pKi = 5.7 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 267 5 2 5 0.9 CCS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70973 211010 0 None -2 5 Human 5.7 pKi = 5.7 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 267 5 2 5 0.9 CCS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
19085832 170555 0 None -11 3 Human 6.7 pKi = 6.7 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 483 6 0 7 3.5 Cc1cc(C)c2oc(=O)n(C3CCN(CCCCN4C(=O)c5ccccc5S4(=O)=O)CC3)c2c1 10.1016/s0960-894x(98)00446-6
CHEMBL420578 170555 0 None -11 3 Human 6.7 pKi = 6.7 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 483 6 0 7 3.5 Cc1cc(C)c2oc(=O)n(C3CCN(CCCCN4C(=O)c5ccccc5S4(=O)=O)CC3)c2c1 10.1016/s0960-894x(98)00446-6
10643994 84031 0 None -2 3 Rat 5.7 pKi = 5.7 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 388 4 3 8 0.9 COc1cc2nc(N3CCN[C@@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
CHEMBL2079655 84031 0 None -2 3 Rat 5.7 pKi = 5.7 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 388 4 3 8 0.9 COc1cc2nc(N3CCN[C@@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
10698974 97897 0 None -117 3 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 610 5 1 7 4.3 COC(=O)C1=C(C)NC(=O)N(C(=O)N2CCC(N3CCC(C(=O)OC)(c4ccccc4)CC3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL239806 97897 0 None -117 3 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 610 5 1 7 4.3 COC(=O)C1=C(C)NC(=O)N(C(=O)N2CCC(N3CCC(C(=O)OC)(c4ccccc4)CC3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
44362633 128325 0 None -138 3 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 597 9 3 6 3.9 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCC(C)N2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL358590 128325 0 None -138 3 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 597 9 3 6 3.9 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCC(C)N2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
49783209 24381 0 None -3981 26 Human 5.6 pKi = 5.6 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 396 7 1 6 3.8 CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 10.1021/jm100668r
CHEMBL1258223 24381 0 None -3981 26 Human 5.6 pKi = 5.6 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 396 7 1 6 3.8 CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1 10.1021/jm100668r
118717461 121921 0 None -6 4 Human 6.6 pKi = 6.6 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 444 12 2 6 6.3 COc1ccc2c(NCCCCCCCNc3ccnc4cc(OC)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343983 121921 0 None -6 4 Human 6.6 pKi = 6.6 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 444 12 2 6 6.3 COc1ccc2c(NCCCCCCCNc3ccnc4cc(OC)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
118717461 121921 0 None -6 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 444 12 2 6 6.3 COc1ccc2c(NCCCCCCCNc3ccnc4cc(OC)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343983 121921 0 None -6 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 444 12 2 6 6.3 COc1ccc2c(NCCCCCCCNc3ccnc4cc(OC)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
11857709 92414 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 556 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
11857709 92414 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 556 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL228389 92414 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 556 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL228389 92414 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 556 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
59151543 146364 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 295 3 2 3 2.4 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccc(Cl)cc1 10.1021/acs.jmedchem.5b01528
CHEMBL3797369 146364 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 295 3 2 3 2.4 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccc(Cl)cc1 10.1021/acs.jmedchem.5b01528
12134996 210866 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 385 6 0 5 3.2 COc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)s2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL70178 210866 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 385 6 0 5 3.2 COc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)s2)CC1 10.1016/s0960-894x(02)00347-5
11268507 203373 0 None 2 2 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 363 4 0 4 2.6 CC1(C)CC(=O)N(CCN2CCN(c3ccccc3Cl)CC2)C(=O)C1 10.1021/jm030944+
CHEMBL56403 203373 0 None 2 2 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 363 4 0 4 2.6 CC1(C)CC(=O)N(CCN2CCN(c3ccccc3Cl)CC2)C(=O)C1 10.1021/jm030944+
118716720 121792 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 425 5 0 7 1.0 COc1ccccc1N1CCN(CC2COC3(CCN(S(C)(=O)=O)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342873 121792 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 425 5 0 7 1.0 COc1ccccc1N1CCN(CC2COC3(CCN(S(C)(=O)=O)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
9959689 108590 0 None -281 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 568 7 2 7 3.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL300222 108590 0 None -281 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 568 7 2 7 3.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
10792591 213602 0 None -104 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 542 7 1 4 4.7 CC(=O)N1C(=O)N(C)C(C)=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm990612y
CHEMBL90453 213602 0 None -104 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 542 7 1 4 4.7 CC(=O)N1C(=O)N(C)C(C)=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm990612y
10769037 43982 0 None -70 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 551 7 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL145332 43982 0 None -70 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 551 7 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
10769058 172457 0 None -208 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 552 6 2 5 4.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CCc4ccccc43)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL424494 172457 0 None -208 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 552 6 2 5 4.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CCc4ccccc43)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
44288841 107916 0 None -26 3 Human 6.6 pKi = 6.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 440 8 1 2 5.8 Cc1ccc(C(C(=O)NCCCN2CCC(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL295304 107916 0 None -26 3 Human 6.6 pKi = 6.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 440 8 1 2 5.8 Cc1ccc(C(C(=O)NCCCN2CCC(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
44288794 168855 0 None -45 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 429 8 1 3 5.0 N#CC1(c2ccccc2)CCN(CCCNC(=O)C(c2ccccc2)C2CCCC2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL416073 168855 0 None -45 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 429 8 1 3 5.0 N#CC1(c2ccccc2)CCN(CCCNC(=O)C(c2ccccc2)C2CCCC2)CC1 10.1016/s0960-894x(00)00307-3
71062646 156322 0 None -3801 13 Mouse 5.6 pKi = 5.6 Binding
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 338 6 0 4 2.8 c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1 nan
CHEMBL3946661 156322 0 None -3801 13 Mouse 5.6 pKi = 5.6 Binding
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 338 6 0 4 2.8 c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1 nan
3952 8669 38 None -6 12 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5353646 8669 38 None -6 12 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5443 8669 38 None -6 12 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
5702063 8669 38 None -6 12 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
CHEMBL1331786 8669 38 None -6 12 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
CHEMBL420 8669 38 None -6 12 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N nan
3652 53018 70 None 1 9 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 nan
CHEMBL1535 53018 70 None 1 9 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 nan
9947861 210941 0 None -4 4 Human 5.6 pKi = 5.6 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 287 4 2 5 1.2 CS(=O)(=O)c1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70634 210941 0 None -4 4 Human 5.6 pKi = 5.6 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 287 4 2 5 1.2 CS(=O)(=O)c1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
3086326 211310 22 None -64 6 Human 5.6 pKi = 5.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 247 1 2 5 1.7 Clc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL72753 211310 22 None -64 6 Human 5.6 pKi = 5.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 247 1 2 5 1.7 Clc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
44431560 95939 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.008
CHEMBL236621 95939 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.008
44431607 154373 0 None -42 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccc(Cl)c3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL393105 154373 0 None -42 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccc(Cl)c3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
44431560 95939 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL236621 95939 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
134551 7146 27 None -10 21 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
271 7146 27 None -10 21 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
885 7146 27 None -10 21 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
CHEMBL1403281 7146 27 None -10 21 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C nan
1043 8363 14 None -263 29 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
149 8363 14 None -263 29 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
8223 8363 14 None -263 29 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
CHEMBL442 8363 14 None -263 29 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
DB00696 8363 14 None -263 29 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O nan
44331150 11202 0 None -3 3 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 530 6 1 7 4.4 Cn1cnc(S(=O)(=O)Nc2ccc3c(c2)C(=O)CC2(CCN(CCc4cccc5ccccc45)CC2)O3)c1 10.1016/s0960-894x(98)00732-x
CHEMBL101579 11202 0 None -3 3 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 530 6 1 7 4.4 Cn1cnc(S(=O)(=O)Nc2ccc3c(c2)C(=O)CC2(CCN(CCc4cccc5ccccc45)CC2)O3)c1 10.1016/s0960-894x(98)00732-x
11211017 205013 0 None -1 6 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 373 4 0 4 2.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)cc2)CC1 10.1021/jm030944+
CHEMBL57546 205013 0 None -1 6 Rat 7.6 pKi = 7.6 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 373 4 0 4 2.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)cc2)CC1 10.1021/jm030944+
44431551 93986 0 None -33 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccc(F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL232780 93986 0 None -33 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccc(F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
11282574 44506 0 None -3 3 Human 7.6 pKi = 7.6 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 459 5 2 5 4.4 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccccc1C(F)(F)F)C3 10.1021/jm030952q
CHEMBL145785 44506 0 None -3 3 Human 7.6 pKi = 7.6 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 459 5 2 5 4.4 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccccc1C(F)(F)F)C3 10.1021/jm030952q
10767264 213773 0 None -616 3 Human 6.6 pKi = 6.6 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 486 7 3 3 4.1 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
CHEMBL91405 213773 0 None -616 3 Human 6.6 pKi = 6.6 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 486 7 3 3 4.1 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
10815593 213818 0 None -1995 3 Human 6.6 pKi = 6.6 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 511 7 2 4 3.7 CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC1=O 10.1021/jm990612y
CHEMBL91616 213818 0 None -1995 3 Human 6.6 pKi = 6.6 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 511 7 2 4 3.7 CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC1=O 10.1021/jm990612y
10696866 213712 0 None -15135 3 Human 5.6 pKi = 5.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 504 7 3 5 3.1 N#Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
CHEMBL91091 213712 0 None -15135 3 Human 5.6 pKi = 5.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 504 7 3 5 3.1 N#Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
44288995 169663 0 None -100 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 435 8 1 3 4.9 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(F)cc2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL417350 169663 0 None -100 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 435 8 1 3 4.9 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(F)cc2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
1016 10519 78 None -22 35 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 10519 78 None -22 35 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 10519 78 None -22 35 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 10519 78 None -22 35 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 10519 78 None -22 35 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 10519 78 None -22 35 Human 5.6 pKi = 5.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
10950355 119378 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 445 7 2 5 3.3 CCCCc1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 10.1016/j.ejmech.2011.03.054
CHEMBL330198 119378 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 445 7 2 5 3.3 CCCCc1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 10.1016/j.ejmech.2011.03.054
136680383 174781 0 None -144 3 Human 6.6 pKi = 6.6 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(N)=O)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
44328800 174781 0 None -144 3 Human 6.6 pKi = 6.6 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(N)=O)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL432026 174781 0 None -144 3 Human 6.6 pKi = 6.6 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(N)=O)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
19085876 212593 0 None -301 3 Human 7.6 pKi = 7.6 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 473 6 0 7 3.0 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL83272 212593 0 None -301 3 Human 7.6 pKi = 7.6 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 473 6 0 7 3.0 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1 10.1016/s0960-894x(98)00446-6
18738386 210817 0 None -125 3 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 413 7 0 5 4.0 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL69848 210817 0 None -125 3 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 413 7 0 5 4.0 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00347-5
16041449 101995 0 None 1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL256040 101995 0 None 1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
49781680 24657 0 None -25 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 414 2 0 3 6.0 Cc1cccc(C)c1-c1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
CHEMBL1259097 24657 0 None -25 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 414 2 0 3 6.0 Cc1cccc(C)c1-c1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
14378574 115364 0 None 4 5 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 327 2 2 5 2.8 COc1cc2c(cc1O)CCN1Cc3c(ccc(O)c3OC)C[C@@H]21 10.1021/jm0307741
CHEMBL320397 115364 0 None 4 5 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 327 2 2 5 2.8 COc1cc2c(cc1O)CCN1Cc3c(ccc(O)c3OC)C[C@@H]21 10.1021/jm0307741
10673466 168543 0 None 3 3 Rat 7.6 pKi = 7.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 481 4 1 6 4.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5c(Cl)cccc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL41396 168543 0 None 3 3 Rat 7.6 pKi = 7.6 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 481 4 1 6 4.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5c(Cl)cccc54)c3=O)C[C@@H]21 10.1021/jm990567u
9981635 43684 0 None -1 3 Human 7.6 pKi = 7.6 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 459 5 2 5 4.4 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1cccc(C(F)(F)F)c1)C3 10.1021/jm030952q
CHEMBL145098 43684 0 None -1 3 Human 7.6 pKi = 7.6 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 459 5 2 5 4.4 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1cccc(C(F)(F)F)c1)C3 10.1021/jm030952q
CHEMBL2112853 43684 0 None -1 3 Human 7.6 pKi = 7.6 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 459 5 2 5 4.4 COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1cccc(C(F)(F)F)c1)C3 10.1021/jm030952q
9872851 103860 3 None -125 3 Human 7.6 pKi = 7.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 571 10 1 7 4.6 COc1ccc(CCN2CCC(c3nc(COCC(F)(F)F)c(-c4ccc(F)cc4)o3)CC2)cc1S(N)(=O)=O 10.1021/jm960697s
CHEMBL267336 103860 3 None -125 3 Human 7.6 pKi = 7.6 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 571 10 1 7 4.6 COc1ccc(CCN2CCC(c3nc(COCC(F)(F)F)c(-c4ccc(F)cc4)o3)CC2)cc1S(N)(=O)=O 10.1021/jm960697s
155567201 183007 0 None -15 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 9 1 5 4.2 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)OC1 10.1016/j.ejmech.2019.05.024
CHEMBL4588223 183007 0 None -15 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 9 1 5 4.2 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)OC1 10.1016/j.ejmech.2019.05.024
CHEMBL4594654 183007 0 None -15 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 9 1 5 4.2 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)OC1 10.1016/j.ejmech.2019.05.024
71521479 93034 0 None -81 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNC[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
CHEMBL2312536 93034 0 None -81 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNC[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
118716699 121609 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 348 4 0 6 1.7 COc1ccccc1N1CCN(CC2COC3(CCOCC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3341769 121609 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 348 4 0 6 1.7 COc1ccccc1N1CCN(CC2COC3(CCOCC3)O2)CC1 10.1016/j.ejmech.2014.09.070
44298650 169934 0 None -100 3 Human 7.6 pKi = 7.6 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 448 7 1 6 2.0 O=c1[nH]cc(F)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
CHEMBL417954 169934 0 None -100 3 Human 7.6 pKi = 7.6 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 448 7 1 6 2.0 O=c1[nH]cc(F)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
9891937 201527 0 None -31 3 Human 7.6 pKi = 7.6 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 458 8 1 6 2.4 CCc1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
CHEMBL53675 201527 0 None -31 3 Human 7.6 pKi = 7.6 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 458 8 1 6 2.4 CCc1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
46881493 13760 0 None -3 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 389 8 1 4 4.3 Cc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
CHEMBL1084658 13760 0 None -3 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 389 8 1 4 4.3 Cc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
10739024 76608 0 None -10 6 Human 6.6 pKi = 6.6 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 388 4 3 8 0.9 COc1cc2nc(N3CCN[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
CHEMBL19376 76608 0 None -10 6 Human 6.6 pKi = 6.6 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 388 4 3 8 0.9 COc1cc2nc(N3CCN[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
59151572 146663 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 262 3 2 4 1.2 N=c1c(C(N)=O)cc(Cl)cn1Cc1cccnc1 10.1021/acs.jmedchem.5b01528
CHEMBL3799335 146663 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 262 3 2 4 1.2 N=c1c(C(N)=O)cc(Cl)cn1Cc1cccnc1 10.1021/acs.jmedchem.5b01528
10626493 214166 0 None -831 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 550 7 1 5 4.0 CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)N(C)C1=O 10.1021/jm990612y
CHEMBL93843 214166 0 None -831 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 550 7 1 5 4.0 CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)N(C)C1=O 10.1021/jm990612y
9985476 44058 0 None -1584 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 570 8 3 7 2.5 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145394 44058 0 None -1584 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 570 8 3 7 2.5 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
10651636 44635 0 None -4168 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 630 8 2 5 6.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccc(C)cc3)(c3ccccc3C)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL145894 44635 0 None -4168 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 630 8 2 5 6.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccc(C)cc3)(c3ccccc3C)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
44288816 162090 0 None -40 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 443 8 1 3 5.4 N#CC1(c2ccccc2)CCN(CCCNC(=O)C(c2ccccc2)C2CCCCC2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL40303 162090 0 None -40 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 443 8 1 3 5.4 N#CC1(c2ccccc2)CCN(CCCNC(=O)C(c2ccccc2)C2CCCCC2)CC1 10.1016/s0960-894x(00)00307-3
9815005 116438 0 None -1 3 Rat 5.6 pKi = 5.6 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 305 3 2 3 2.6 CS(=O)(=O)Nc1cccc2c1CCCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL322492 116438 0 None -1 3 Rat 5.6 pKi = 5.6 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 305 3 2 3 2.6 CS(=O)(=O)Nc1cccc2c1CCCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
9815005 116438 0 None -1 3 Rat 5.6 pKi = 5.6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 3 2 3 2.6 CS(=O)(=O)Nc1cccc2c1CCCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL322492 116438 0 None -1 3 Rat 5.6 pKi = 5.6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 3 2 3 2.6 CS(=O)(=O)Nc1cccc2c1CCCCC2c1c[nH]cn1 10.1021/jm030551a
18738380 18713 0 None -8 3 Human 6.6 pKi = 6.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 417 9 1 6 1.9 CC(C)Oc1ccccc1N1CCN(CC(O)CC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL11828 18713 0 None -8 3 Human 6.6 pKi = 6.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 417 9 1 6 1.9 CC(C)Oc1ccccc1N1CCN(CC(O)CC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
92766 113319 35 None -2 6 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 10.1021/jm00019a001
CHEMBL31410 113319 35 None -2 6 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 10.1021/jm00019a001
1531 9046 69 None -14 16 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
3869 9046 69 None -14 16 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
7207 9046 69 None -14 16 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
CHEMBL429 9046 69 None -14 16 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
DB00598 9046 69 None -14 16 Human 6.6 pKi = 6.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O nan
11857791 92415 0 None -12 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 554 7 1 6 4.9 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc2c(c1)OCCO2 10.1016/j.bmcl.2007.04.098
CHEMBL228390 92415 0 None -12 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 554 7 1 6 4.9 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc2c(c1)OCCO2 10.1016/j.bmcl.2007.04.098
1201549 7384 24 None -12 20 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
333 7384 24 None -12 20 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
7601 7384 24 None -12 20 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
CHEMBL1201203 7384 24 None -12 20 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
CHEMBL438151 7384 24 None -12 20 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
DB00245 7384 24 None -12 20 Human 7.6 pKi = 7.6 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 nan
59151614 146689 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 304 4 3 4 0.9 N=c1c(C(N)=O)cc(Cl)cn1Cc1cccc(C(N)=O)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3799486 146689 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 304 4 3 4 0.9 N=c1c(C(N)=O)cc(Cl)cn1Cc1cccc(C(N)=O)c1 10.1021/acs.jmedchem.5b01528
44222842 201871 0 None -1 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1021/jm8016046
CHEMBL549764 201871 0 None -1 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1021/jm8016046
118716716 121788 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 571 7 0 8 3.3 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(OC(F)(F)F)cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342869 121788 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 571 7 0 8 3.3 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(OC(F)(F)F)cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
16041628 162129 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL403280 162129 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
9824384 125565 1 None -7 8 Rat 7.6 pKi = 7.6 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain using radioligand ([3H]prazosin) binding assayCompound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain using radioligand ([3H]prazosin) binding assay
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1021/jm960510x
CHEMBL342062 125565 1 None -7 8 Rat 7.6 pKi = 7.6 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain using radioligand ([3H]prazosin) binding assayCompound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain using radioligand ([3H]prazosin) binding assay
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1021/jm960510x
44428850 99070 0 None -4 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 448 4 1 8 2.9 COc1cc2nc(N3CCN(C(=O)c4ccccn4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL242725 99070 0 None -4 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 448 4 1 8 2.9 COc1cc2nc(N3CCN(C(=O)c4ccccn4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
118716710 121782 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 444 5 1 7 1.3 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)C4CCCN4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342863 121782 0 None -2 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 444 5 1 7 1.3 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)C4CCCN4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
9890459 23703 0 None -13 3 Human 6.6 pKi = 6.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 460 10 1 7 1.3 CCOC(=O)C1CCC(=O)N1CC(=O)NCCN1CCN(c2ccccc2OC(C)C)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL12529 23703 0 None -13 3 Human 6.6 pKi = 6.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 460 10 1 7 1.3 CCOC(=O)C1CCC(=O)N1CC(=O)NCCN1CCN(c2ccccc2OC(C)C)CC1 10.1016/s0960-894x(00)00169-4
10840194 118605 0 None -1862 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 541 9 3 5 3.6 COCC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
CHEMBL328763 118605 0 None -1862 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 541 9 3 5 3.6 COCC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
10369288 214037 0 None -1096 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 516 9 3 4 3.7 COCC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
CHEMBL92951 214037 0 None -1096 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 516 9 3 4 3.7 COCC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
10627090 41335 0 None -2630 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 581 9 2 7 3.8 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL142929 41335 0 None -2630 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 581 9 2 7 3.8 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
10555223 43899 0 None -263 3 Human 5.6 pKi = 5.6 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 579 9 3 8 3.3 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC(C)=C(C(=O)O)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1021/jm990200p
CHEMBL145267 43899 0 None -263 3 Human 5.6 pKi = 5.6 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 579 9 3 8 3.3 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC(C)=C(C(=O)O)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1021/jm990200p
10026936 170237 0 None -204 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 8 1 3 5.1 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(F)c(F)c2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL41994 170237 0 None -204 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 453 8 1 3 5.1 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(F)c(F)c2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
12134994 170086 0 None 2 3 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 316 5 0 5 2.9 COc1ccccc1N1CCN(Cc2ccc(C=O)s2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL418882 170086 0 None 2 3 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 316 5 0 5 2.9 COc1ccccc1N1CCN(Cc2ccc(C=O)s2)CC1 10.1016/s0960-894x(02)00347-5
10764133 91347 0 None -2 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2c(OC)cccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153560 91347 0 None -2 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2c(OC)cccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2220899 91347 0 None -2 4 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@@H]1COc2c(OC)cccc2O1 10.1016/j.ejmech.2012.09.049
10199335 211526 0 None -3 4 Human 5.6 pKi = 5.6 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL74467 211526 0 None -3 4 Human 5.6 pKi = 5.6 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
131829 211506 15 None -416 6 Human 5.6 pKi = 5.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 295 1 4 5 1.7 Brc1c(NC2=NCCN2)ccc2c1NCCN2 10.1016/0960-894X(95)00391-6
CHEMBL74283 211506 15 None -416 6 Human 5.6 pKi = 5.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 295 1 4 5 1.7 Brc1c(NC2=NCCN2)ccc2c1NCCN2 10.1016/0960-894X(95)00391-6
10267873 117437 0 None -5 2 Rat 5.6 pKi = 5.6 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 317 4 2 3 2.8 O=S(=O)(Nc1cccc2c1CCCC2c1c[nH]cn1)C1CC1 10.1007/s00044-004-0020-z
CHEMBL325897 117437 0 None -5 2 Rat 5.6 pKi = 5.6 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 317 4 2 3 2.8 O=S(=O)(Nc1cccc2c1CCCC2c1c[nH]cn1)C1CC1 10.1007/s00044-004-0020-z
9796526 116661 0 None -6 2 Rat 5.6 pKi = 5.6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 3 2 3 2.6 Cc1ccc(NS(C)(=O)=O)c2c1C(c1c[nH]cn1)CCC2 10.1021/jm030551a
CHEMBL323440 116661 0 None -6 2 Rat 5.6 pKi = 5.6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 3 2 3 2.6 Cc1ccc(NS(C)(=O)=O)c2c1C(c1c[nH]cn1)CCC2 10.1021/jm030551a
10267873 117437 0 None -5 2 Rat 5.6 pKi = 5.6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 317 4 2 3 2.8 O=S(=O)(Nc1cccc2c1CCCC2c1c[nH]cn1)C1CC1 10.1021/jm030551a
CHEMBL325897 117437 0 None -5 2 Rat 5.6 pKi = 5.6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 317 4 2 3 2.8 O=S(=O)(Nc1cccc2c1CCCC2c1c[nH]cn1)C1CC1 10.1021/jm030551a
44431548 93826 0 None -26 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 502 8 1 7 3.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3[N+](=O)[O-])CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL232593 93826 0 None -26 4 Human 7.6 pKi = 7.6 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 502 8 1 7 3.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3[N+](=O)[O-])CC2)CC1 10.1016/j.bmcl.2007.04.008
56649648 74630 0 None -81 8 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 474 8 0 5 3.0 COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
CHEMBL1910139 74630 0 None -81 8 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 474 8 0 5 3.0 COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
122179431 128221 0 None 1 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 585 9 1 13 3.1 CCN(CC)c1ccc2cc(-n3cc(CN4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 10.1021/ml5004298
CHEMBL3582272 128221 0 None 1 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 585 9 1 13 3.1 CCN(CC)c1ccc2cc(-n3cc(CN4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 10.1021/ml5004298
10603030 214242 0 None -64 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 565 7 3 4 4.5 N#Cc1cc(F)ccc1C1CCN(CCCNC(=O)C2=C(C(F)(F)F)NC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
CHEMBL94259 214242 0 None -64 3 Human 6.6 pKi = 6.6 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 565 7 3 4 4.5 N#Cc1cc(F)ccc1C1CCN(CCCNC(=O)C2=C(C(F)(F)F)NC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
10627279 43987 0 None -128 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 592 9 3 8 3.0 CNC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
CHEMBL145334 43987 0 None -128 3 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 592 9 3 8 3.0 CNC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
44289034 172732 0 None -794 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 435 8 1 3 4.9 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2cccc(F)c2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL42514 172732 0 None -794 3 Human 5.6 pKi = 5.6 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 435 8 1 3 4.9 Cc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2cccc(F)c2)C(C)C)CC1 10.1016/s0960-894x(00)00307-3
12134986 171173 0 None -70 3 Human 6.6 pKi = 6.6 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 412 7 0 6 3.3 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)on2)CC1 10.1016/s0960-894x(00)00472-8
CHEMBL421324 171173 0 None -70 3 Human 6.6 pKi = 6.6 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 412 7 0 6 3.3 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)on2)CC1 10.1016/s0960-894x(00)00472-8
132060812 168815 0 None -724 10 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting method
ChEMBL 329 4 0 2 4.9 COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1 10.1016/j.ejmech.2018.02.024
CHEMBL4160064 168815 0 None -724 10 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting method
ChEMBL 329 4 0 2 4.9 COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1 10.1016/j.ejmech.2018.02.024
16215415 194111 1 None -3 5 Human 6.6 pKi = 6.6 Binding
Inhibition of cloned adrenergic Alpha-1D receptorInhibition of cloned adrenergic Alpha-1D receptor
ChEMBL 471 9 2 3 3.8 CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br 10.1021/np800339e
CHEMBL493091 194111 1 None -3 5 Human 6.6 pKi = 6.6 Binding
Inhibition of cloned adrenergic Alpha-1D receptorInhibition of cloned adrenergic Alpha-1D receptor
ChEMBL 471 9 2 3 3.8 CN(C)CCCOc1ccc(CCNC(=O)c2cc(Br)c[nH]2)cc1Br 10.1021/np800339e
9838192 118089 18 None -2 6 Rat 6.6 pKi = 6.6 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1007/s00044-004-0020-z
CHEMBL326702 118089 18 None -2 6 Rat 6.6 pKi = 6.6 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1007/s00044-004-0020-z
9838192 118089 18 None -2 6 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm030551a
CHEMBL326702 118089 18 None -2 6 Rat 6.6 pKi = 6.6 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm030551a
19085827 111640 0 None -5 3 Human 5.6 pKi = 5.6 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 485 7 0 8 2.9 COc1ccc2c(c1)oc(=O)n2C1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL311014 111640 0 None -5 3 Human 5.6 pKi = 5.6 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 485 7 0 8 2.9 COc1ccc2c(c1)oc(=O)n2C1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/s0960-894x(98)00446-6
136806214 214908 0 None -60 3 Human 4.6 pKi = 4.6 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 633 15 4 9 2.4 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(CN(C)C)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
44329028 214908 0 None -60 3 Human 4.6 pKi = 4.6 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 633 15 4 9 2.4 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(CN(C)C)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL98038 214908 0 None -60 3 Human 4.6 pKi = 4.6 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 633 15 4 9 2.4 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(CN(C)C)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
44312037 211398 1 None -2 6 Human 4.6 pKi = 4.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 308 1 1 5 2.9 Brc1c(NC2=NCCS2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL73392 211398 1 None -2 6 Human 4.6 pKi = 4.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 308 1 1 5 2.9 Brc1c(NC2=NCCS2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
10721568 210629 0 None -32 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 558 9 3 8 2.9 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(O)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL68604 210629 0 None -32 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 558 9 3 8 2.9 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(O)cc2)C3=O)CC1 10.1021/jm9905918
10698570 125536 0 None -562 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 586 8 2 8 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])C[C@H]2C)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL341849 125536 0 None -562 3 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 586 8 2 8 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])C[C@H]2C)C1c1ccc(F)c(F)c1 10.1021/jm990202+
145958538 169044 0 None 1 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 303 3 2 7 1.2 COc1cc2nc(N3CCC[C@H](N)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
CHEMBL4163810 169044 0 None 1 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 303 3 2 7 1.2 COc1cc2nc(N3CCC[C@H](N)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
118716708 121780 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 441 5 0 7 2.5 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccco4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342861 121780 0 None -1 4 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 441 5 0 7 2.5 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccco4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
11995034 18605 0 None -3 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cccc(-c2ccccc2)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182148 18605 0 None -3 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cccc(-c2ccccc2)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL214952 18605 0 None -3 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cccc(-c2ccccc2)c1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
11339351 204090 0 None -7 2 Rat 7.5 pKi = 7.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 427 6 0 6 2.7 CCOC(=O)c1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL56878 204090 0 None -7 2 Rat 7.5 pKi = 7.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 427 6 0 6 2.7 CCOC(=O)c1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
9838192 118089 18 None -2 6 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (0.24 -0.32)Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (0.24 -0.32)
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm025550h
CHEMBL326702 118089 18 None -2 6 Rat 6.6 pKi = 6.6 Binding
Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (0.24 -0.32)Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (0.24 -0.32)
ChEMBL 265 5 2 3 1.8 CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1 10.1021/jm025550h
10382537 210945 12 None -41 6 Human 6.6 pKi = 6.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 339 1 2 5 1.6 Ic1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL70676 210945 12 None -41 6 Human 6.6 pKi = 6.6 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 339 1 2 5 1.6 Ic1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
11811395 211480 0 None -2 4 Human 5.6 pKi = 5.6 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 281 5 2 5 1.3 CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL74071 211480 0 None -2 4 Human 5.6 pKi = 5.6 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 281 5 2 5 1.3 CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
44318075 212145 0 None -3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 460 7 0 6 4.7 O=C1CCCCCN1Cc1cc(CN2CCN(c3ccccc3Oc3ccccc3)CC2)on1 10.1016/s0960-894x(02)00436-5
CHEMBL79817 212145 0 None -3 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 460 7 0 6 4.7 O=C1CCCCCN1Cc1cc(CN2CCN(c3ccccc3Oc3ccccc3)CC2)on1 10.1016/s0960-894x(02)00436-5
10506222 118263 0 None -691 3 Human 6.5 pKi = 6.5 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 523 9 3 5 3.5 COCC1=C(C(=O)NCCCN2CCC(c3ccccc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
CHEMBL327716 118263 0 None -691 3 Human 6.5 pKi = 6.5 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 523 9 3 5 3.5 COCC1=C(C(=O)NCCCN2CCC(c3ccccc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
9905391 116263 0 None -6 2 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 325 3 2 3 2.9 CS(=O)(=O)Nc1ccc(Cl)c2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL322082 116263 0 None -6 2 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 325 3 2 3 2.9 CS(=O)(=O)Nc1ccc(Cl)c2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
102 10899 48 None -363 49 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
3659 10899 48 None -363 49 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
8969 10899 48 None -363 49 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
CHEMBL15245 10899 48 None -363 49 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
DB01392 10899 48 None -363 49 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00019a001
16041264 102218 0 None 1 4 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL257077 102218 0 None 1 4 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
155529118 183343 0 None -2 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 9 1 4 4.2 c1ccc(OCCNC[C@@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4462768 183343 0 None -2 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 9 1 4 4.2 c1ccc(OCCNC[C@@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4597358 183343 0 None -2 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 9 1 4 4.2 c1ccc(OCCNC[C@@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
11281688 204046 0 None 7 2 Rat 7.5 pKi = 7.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2c(Cl)cccc2Cl)CC1 10.1021/jm030944+
CHEMBL56851 204046 0 None 7 2 Rat 7.5 pKi = 7.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2c(Cl)cccc2Cl)CC1 10.1021/jm030944+
10092649 199852 56 None -26 9 Human 6.5 pKi = 6.5 Binding
Binding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assayBinding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assay
ChEMBL 404 4 1 4 3.9 Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 10.1021/jm100697g
CHEMBL522460 199852 56 None -26 9 Human 6.5 pKi = 6.5 Binding
Binding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assayBinding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assay
ChEMBL 404 4 1 4 3.9 Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 10.1021/jm100697g
10674333 44268 0 None -407 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 554 8 3 6 2.9 CC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145574 44268 0 None -407 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 554 8 3 6 2.9 CC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
9916549 128342 0 None -1023 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 592 10 3 8 3.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
CHEMBL358595 128342 0 None -1023 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 592 10 3 8 3.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
44289058 172124 0 None -39 3 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 403 8 1 3 4.5 CC(C)C(C(=O)NCCCN1CCC(C#N)(c2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(00)00307-3
CHEMBL42361 172124 0 None -39 3 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 403 8 1 3 4.5 CC(C)C(C(=O)NCCCN1CCC(C#N)(c2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(00)00307-3
73213196 111237 4 None -2 13 Human 6.5 pKi = 6.5 Binding
Binding affinity to adrenergic alpha 1D receptor (unknown origin)Binding affinity to adrenergic alpha 1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2014.05.016
CHEMBL3104093 111237 4 None -2 13 Human 6.5 pKi = 6.5 Binding
Binding affinity to adrenergic alpha 1D receptor (unknown origin)Binding affinity to adrenergic alpha 1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2014.05.016
73213196 111237 4 None -2 13 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104093 111237 4 None -2 13 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
73213196 111237 4 None -2 13 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104093 111237 4 None -2 13 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.9 CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1 10.1016/j.bmcl.2013.12.024
44417709 19192 0 None -2 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 395 8 1 6 3.7 COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3ccccc3cc2O1 10.1021/jm060358r
CHEMBL1185857 19192 0 None -2 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 395 8 1 6 3.7 COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3ccccc3cc2O1 10.1021/jm060358r
CHEMBL436955 19192 0 None -2 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 395 8 1 6 3.7 COc1cccc(OC)c1OCCNC[C@@H]1COc2cc3ccccc3cc2O1 10.1021/jm060358r
145962085 168780 0 None -6 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 465 5 2 9 2.2 COc1cc2nc(N3CCC[C@@H](NC(=O)[C@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
CHEMBL4159468 168780 0 None -6 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 465 5 2 9 2.2 COc1cc2nc(N3CCC[C@@H](NC(=O)[C@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
10804826 30387 2 None -3 4 Rat 5.5 pKi = 5.5 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1 10.1021/jm960354u
CHEMBL133451 30387 2 None -3 4 Rat 5.5 pKi = 5.5 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 309 3 3 5 1.2 CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1 10.1021/jm960354u
11857791 175776 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 554 7 1 6 4.9 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc2c(c1)OCCO2 10.1016/j.bmcl.2007.04.098
CHEMBL439197 175776 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 554 7 1 6 4.9 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc2c(c1)OCCO2 10.1016/j.bmcl.2007.04.098
16041263 102222 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL257098 102222 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
9982050 108711 0 None -2 4 Human 8.5 pKi = 8.5 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 467 6 1 9 2.5 COc1ccccc1N1CCN(CCNc2ccc3c4c(=O)n(C)nc(Cl)c4cn3n2)CC1 10.1021/jm981006q
CHEMBL301078 108711 0 None -2 4 Human 8.5 pKi = 8.5 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 467 6 1 9 2.5 COc1ccccc1N1CCN(CCNc2ccc3c4c(=O)n(C)nc(Cl)c4cn3n2)CC1 10.1021/jm981006q
134152568 159866 0 None -1 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 354 7 0 4 3.8 COc1ccc(CCN2CCN(c3ccccc3OC(C)C)CC2)cc1 10.1016/j.ejmech.2016.06.052
CHEMBL3976144 159866 0 None -1 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 354 7 0 4 3.8 COc1ccc(CCN2CCN(c3ccccc3OC(C)C)CC2)cc1 10.1016/j.ejmech.2016.06.052
10973768 114337 0 None -7 10 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 563 6 1 8 4.4 Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
CHEMBL318901 114337 0 None -7 10 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 563 6 1 8 4.4 Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
10511224 66101 7 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 164 2 1 2 2.1 c1nc(Cc2ccsc2)c[nH]1 10.1021/jm0003891
CHEMBL170614 66101 7 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 164 2 1 2 2.1 c1nc(Cc2ccsc2)c[nH]1 10.1021/jm0003891
CHEMBL1744292 66101 7 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 164 2 1 2 2.1 c1nc(Cc2ccsc2)c[nH]1 10.1021/jm0003891
9909471 203685 0 None 17 4 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 409 4 0 4 3.4 O=C1CC2(CCCC2)C(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL56620 203685 0 None 17 4 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 409 4 0 4 3.4 O=C1CC2(CCCC2)C(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
11303180 205005 0 None 1 5 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 369 5 0 4 3.1 COc1ccccc1N1CCN(CCN2C=CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL57540 205005 0 None 1 5 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 369 5 0 4 3.1 COc1ccccc1N1CCN(CCN2C=CC3(CCCC3)CC2=O)CC1 10.1021/jm030944+
115 7131 71 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm960697s
2092 7131 71 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm960697s
7109 7131 71 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm960697s
CHEMBL709 7131 71 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm960697s
DB00346 7131 71 None -1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm960697s
126225 101751 5 None 1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 263 1 0 2 4.2 C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm960697s
CHEMBL25467 101751 5 None 1 7 Human 8.5 pKi = 8.5 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 263 1 0 2 4.2 C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 10.1021/jm960697s
44431546 94917 0 None -4 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 482 7 1 6 3.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3C#N)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234680 94917 0 None -4 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 482 7 1 6 3.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3C#N)CC2)CC1 10.1016/j.bmcl.2007.04.008
11014848 211903 0 None -1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 399 7 1 8 1.5 COc1ccccc1N1CCN(CCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL77901 211903 0 None -1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 399 7 1 8 1.5 COc1ccccc1N1CCN(CCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 10.1021/jm0009336
9824384 125565 1 None -2 8 Human 8.5 pKi = 8.5 Binding
Compound was tested for binding affinity against human hippocampus Alpha-1D adrenergic receptor using radioligand ([3H]prazosin) binding assayCompound was tested for binding affinity against human hippocampus Alpha-1D adrenergic receptor using radioligand ([3H]prazosin) binding assay
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1021/jm960510x
CHEMBL342062 125565 1 None -2 8 Human 8.5 pKi = 8.5 Binding
Compound was tested for binding affinity against human hippocampus Alpha-1D adrenergic receptor using radioligand ([3H]prazosin) binding assayCompound was tested for binding affinity against human hippocampus Alpha-1D adrenergic receptor using radioligand ([3H]prazosin) binding assay
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1021/jm960510x
90645594 119263 0 None 2 3 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 597 10 2 8 4.7 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298747 119263 0 None 2 3 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 597 10 2 8 4.7 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
10252540 92132 1 None -15 6 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL2261604 92132 1 None -15 6 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 437 4 1 8 3.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
132266 8061 12 None -5 9 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2007.01.028
486 8061 12 None -5 9 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2007.01.028
CHEMBL423294 8061 12 None -5 9 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2007.01.028
44428851 99093 0 None -6 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 447 4 1 7 3.5 COc1cc2nc(N3CCN(C(=O)c4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL242934 99093 0 None -6 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 447 4 1 7 3.5 COc1cc2nc(N3CCN(C(=O)c4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
132266 8061 12 None -5 9 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2018.05.023
486 8061 12 None -5 9 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2018.05.023
CHEMBL423294 8061 12 None -5 9 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1016/j.bmc.2018.05.023
25181489 194136 0 None -3 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm301525w
CHEMBL493285 194136 0 None -3 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm301525w
9929277 107755 0 None 16 4 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 369 4 0 4 2.7 O=C1CCCC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL294235 107755 0 None 16 4 Rat 8.5 pKi = 8.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 369 4 0 4 2.7 O=C1CCCC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
10552608 107194 0 None -8 3 Rat 8.5 pKi = 8.5 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 477 4 1 8 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5nc(C)c(C)nc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL290243 107194 0 None -8 3 Rat 8.5 pKi = 8.5 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 477 4 1 8 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5nc(C)c(C)nc54)c3=O)C[C@@H]21 10.1021/jm990567u
44431551 93985 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccc(F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL232779 93985 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccc(F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
90645603 119213 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 567 8 1 8 4.9 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)Cc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298021 119213 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 567 8 1 8 4.9 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)Cc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
11994665 18606 0 None -3 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182151 18606 0 None -3 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL215151 18606 0 None -3 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
44431555 95937 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 535 8 1 7 3.3 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(S(C)(=O)=O)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL236617 95937 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 535 8 1 7 3.3 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(S(C)(=O)=O)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
3584 10549 64 None -1 14 Rat 8.5 pKi = 8.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
5401 10549 64 None -1 14 Rat 8.5 pKi = 8.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
7302 10549 64 None -1 14 Rat 8.5 pKi = 8.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
CHEMBL611 10549 64 None -1 14 Rat 8.5 pKi = 8.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
DB01162 10549 64 None -1 14 Rat 8.5 pKi = 8.5 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980053f
58150016 146849 1 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 300 3 2 4 2.2 CC(c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
CHEMBL3800470 146849 1 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 300 3 2 4 2.2 CC(c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
3584 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
5401 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
7302 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
CHEMBL611 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
DB01162 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm980077m
136 10065 32 None -107 16 Human 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
223 10065 32 None -107 16 Human 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
643606 10065 32 None -107 16 Human 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
CHEMBL10347 10065 32 None -107 16 Human 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
3584 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
5401 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
7302 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
CHEMBL611 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
DB01162 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
115 7131 71 None -1 7 Rat 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
2092 7131 71 None -1 7 Rat 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
7109 7131 71 None -1 7 Rat 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
CHEMBL709 7131 71 None -1 7 Rat 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
DB00346 7131 71 None -1 7 Rat 8.5 pKi = 8.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
3584 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990200p
3584 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990202+
5401 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990200p
5401 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990202+
7302 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990200p
7302 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990202+
CHEMBL611 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990200p
CHEMBL611 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990202+
DB01162 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990200p
DB01162 10549 64 None -1 14 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm990202+
11039289 123618 0 None -37 5 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 600 13 1 9 4.7 Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCCCO[N+](=O)[O-])CC3)cccc2c1=O 10.1021/jm030825u
CHEMBL338029 123618 0 None -37 5 Human 8.5 pKi = 8.5 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 600 13 1 9 4.7 Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCCCO[N+](=O)[O-])CC3)cccc2c1=O 10.1021/jm030825u
115 7131 71 None -1 7 Human 8.4 pKi = 8.4 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
2092 7131 71 None -1 7 Human 8.4 pKi = 8.4 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
7109 7131 71 None -1 7 Human 8.4 pKi = 8.4 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
CHEMBL709 7131 71 None -1 7 Human 8.4 pKi = 8.4 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
DB00346 7131 71 None -1 7 Human 8.4 pKi = 8.4 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
ChEMBL 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10.1021/jm00018a001
44431616 94851 0 None -3 4 Human 8.4 pKi = 8.4 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 471 8 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234649 94851 0 None -3 4 Human 8.4 pKi = 8.4 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 471 8 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)Cc3ccccc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
49781448 24622 0 None -6 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 406 2 0 4 5.7 Cc1ccc(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)s1 10.1021/jm100652h
CHEMBL1259005 24622 0 None -6 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 406 2 0 4 5.7 Cc1ccc(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)s1 10.1021/jm100652h
10678895 65646 4 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1ccc(Cc2c[nH]cn2)s1 10.1021/jm0003891
CHEMBL1203847 65646 4 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1ccc(Cc2c[nH]cn2)s1 10.1021/jm0003891
CHEMBL168865 65646 4 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 178 2 1 2 2.4 Cc1ccc(Cc2c[nH]cn2)s1 10.1021/jm0003891
107715 207724 22 None -13 20 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL1255837 207724 22 None -13 20 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
CHEMBL601773 207724 22 None -13 20 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O nan
11133288 172812 0 None -9 7 Human 8.4 pKi = 8.4 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 407 12 1 5 4.3 COc1cccc(OC)c1OCCNCCOc1ccccc1Cc1ccccc1 10.1021/jm011066n
CHEMBL42558 172812 0 None -9 7 Human 8.4 pKi = 8.4 Binding
Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptorAffinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
ChEMBL 407 12 1 5 4.3 COc1cccc(OC)c1OCCNCCOc1ccccc1Cc1ccccc1 10.1021/jm011066n
25131198 93035 0 None -6 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNCC2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.02.056
CHEMBL2312537 93035 0 None -6 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNCC2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.02.056
76308474 113011 0 None -4 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@H]3CCCC[C@@H]32)o1 10.1007/s00044-004-0024-8
CHEMBL2261607 113011 0 None -4 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@H]3CCCC[C@@H]32)o1 10.1007/s00044-004-0024-8
CHEMBL3138856 113011 0 None -4 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@H]3CCCC[C@@H]32)o1 10.1007/s00044-004-0024-8
44428846 98964 0 None -4 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@@H]3CCCC[C@@H]32)o1 10.1016/j.bmc.2007.01.028
CHEMBL242508 98964 0 None -4 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 467 5 1 9 3.1 COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@@H]3CCCC[C@@H]32)o1 10.1016/j.bmc.2007.01.028
25181489 194136 0 None -3 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm800461k
CHEMBL493285 194136 0 None -3 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNC[C@@H]2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm800461k
25131198 93035 0 None -6 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNCC2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm301525w
CHEMBL2312537 93035 0 None -6 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNCC2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm301525w
11348796 107506 4 None 7 3 Rat 8.4 pKi = 8.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 354 4 0 3 3.6 O=C1CC2(CCCC2)CC(=O)N1CCN1CCC(c2ccccc2)CC1 10.1021/jm030944+
CHEMBL292686 107506 4 None 7 3 Rat 8.4 pKi = 8.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 354 4 0 3 3.6 O=C1CC2(CCCC2)CC(=O)N1CCN1CCC(c2ccccc2)CC1 10.1021/jm030944+
3584 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
5401 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
7302 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
CHEMBL611 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
DB01162 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00010a001
57929587 146763 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 338 4 3 4 1.5 N=c1c(C(N)=O)cc(Cl)cn1Cc1cc(Cl)cc(C(N)=O)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3799912 146763 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 338 4 3 4 1.5 N=c1c(C(N)=O)cc(Cl)cn1Cc1cc(Cl)cc(C(N)=O)c1 10.1021/acs.jmedchem.5b01528
16041449 101995 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL256040 101995 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
9877827 127526 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 218 2 1 2 2.9 c1nc(Cc2cc3c(s2)CCCC3)c[nH]1 10.1021/jm0003891
CHEMBL1203856 127526 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 218 2 1 2 2.9 c1nc(Cc2cc3c(s2)CCCC3)c[nH]1 10.1021/jm0003891
CHEMBL355043 127526 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 218 2 1 2 2.9 c1nc(Cc2cc3c(s2)CCCC3)c[nH]1 10.1021/jm0003891
10606670 205871 0 None -14 3 Rat 8.4 pKi = 8.4 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 465 6 0 8 2.4 COc1cc2c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)n(C)c2cc1OC 10.1021/jm000541z
CHEMBL58862 205871 0 None -14 3 Rat 8.4 pKi = 8.4 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 465 6 0 8 2.4 COc1cc2c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)n(C)c2cc1OC 10.1021/jm000541z
52941004 23863 0 None -1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 407 13 1 5 4.7 CCOc1ccccc1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1254914 23863 0 None -1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 407 13 1 5 4.7 CCOc1ccccc1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
145953314 168208 0 None -4 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 441 7 1 7 3.8 CCCCCC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)cc3n2)[C@@H]2CCCC[C@@H]21 10.1016/j.bmc.2018.05.023
CHEMBL4127078 168208 0 None -4 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 441 7 1 7 3.8 CCCCCC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)cc3n2)[C@@H]2CCCC[C@@H]21 10.1016/j.bmc.2018.05.023
9892644 204125 0 None 12 4 Rat 8.4 pKi = 8.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 511 4 0 4 4.0 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(Br)ccc2Br)CC1 10.1021/jm030944+
CHEMBL56899 204125 0 None 12 4 Rat 8.4 pKi = 8.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 511 4 0 4 4.0 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(Br)ccc2Br)CC1 10.1021/jm030944+
10813408 165132 0 None -2 3 Rat 8.4 pKi = 8.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 449 4 1 8 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cncnc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL40896 165132 0 None -2 3 Rat 8.4 pKi = 8.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 449 4 1 8 2.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cncnc54)c3=O)C[C@@H]21 10.1021/jm990567u
10368033 107201 0 None -5 4 Rat 8.4 pKi = 8.4 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 483 4 1 8 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncc(Cl)nc54)c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL290387 107201 0 None -5 4 Rat 8.4 pKi = 8.4 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 483 4 1 8 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncc(Cl)nc54)c3=O)C[C@@H]21 10.1021/jm000541z
10368033 107201 0 None -5 4 Rat 8.4 pKi = 8.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 483 4 1 8 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncc(Cl)nc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL290387 107201 0 None -5 4 Rat 8.4 pKi = 8.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
ChEMBL 483 4 1 8 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncc(Cl)nc54)c3=O)C[C@@H]21 10.1021/jm990567u
45268939 203439 0 None -1 5 Human 8.4 pKi = 8.4 Binding
Binding affinity to alpha1D adrenergic receptor (unknown origin)Binding affinity to alpha1D adrenergic receptor (unknown origin)
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL564481 203439 0 None -1 5 Human 8.4 pKi = 8.4 Binding
Binding affinity to alpha1D adrenergic receptor (unknown origin)Binding affinity to alpha1D adrenergic receptor (unknown origin)
ChEMBL 505 4 1 9 3.0 COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
11441652 107709 0 None 3 2 Rat 8.4 pKi = 8.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(Cl)cc2Cl)CC1 10.1021/jm030944+
CHEMBL293980 107709 0 None 3 2 Rat 8.4 pKi = 8.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(Cl)cc2Cl)CC1 10.1021/jm030944+
56946573 78301 0 None -6 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 428 6 0 4 4.9 COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1 10.1021/jm200421e
CHEMBL1946780 78301 0 None -6 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 428 6 0 4 4.9 COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1 10.1021/jm200421e
CHEMBL1962870 78301 0 None -6 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 428 6 0 4 4.9 COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1 10.1021/jm200421e
70820427 174438 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 369 5 1 4 3.4 O=S1(=O)CCC(NCCOc2cc(F)ccc2Cl)c2ccccc21 10.1016/j.ejmech.2017.07.071
CHEMBL4205740 174438 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 369 5 1 4 3.4 O=S1(=O)CCC(NCCOc2cc(F)ccc2Cl)c2ccccc21 10.1016/j.ejmech.2017.07.071
CHEMBL4301839 174438 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 369 5 1 4 3.4 O=S1(=O)CCC(NCCOc2cc(F)ccc2Cl)c2ccccc21 10.1016/j.ejmech.2017.07.071
10348924 24717 0 None -5 5 Human 8.4 pKi = 8.4 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 620 10 1 10 3.8 Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C#N)CC3)cccc2c1=O 10.1021/jm030825u
CHEMBL125989 24717 0 None -5 5 Human 8.4 pKi = 8.4 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 620 10 1 10 3.8 Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C#N)CC3)cccc2c1=O 10.1021/jm030825u
10994812 211875 0 None -8 4 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 509 9 1 8 3.9 COc1ccc(Cl)cc1N1CCN(CCCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL77618 211875 0 None -8 4 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 509 9 1 8 3.9 COc1ccc(Cl)cc1N1CCN(CCCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
3157 8252 71 None -1 12 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm960697s
7170 8252 71 None -1 12 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm960697s
954 8252 71 None -1 12 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm960697s
CHEMBL707 8252 71 None -1 12 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm960697s
DB00590 8252 71 None -1 12 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1021/jm960697s
3584 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm960697s
5401 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm960697s
7302 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm960697s
CHEMBL611 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm960697s
DB01162 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm960697s
52941624 23864 0 None -1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 393 12 1 5 4.3 COc1ccccc1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1254915 23864 0 None -1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 393 12 1 5 4.3 COc1ccccc1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
69781970 168130 0 None -10 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 477 5 1 8 4.0 COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4125981 168130 0 None -10 5 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 477 5 1 8 4.0 COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
71458492 91344 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 379 8 1 6 3.2 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(Cl)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153556 91344 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 379 8 1 6 3.2 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(Cl)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2220896 91344 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 379 8 1 6 3.2 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(Cl)c2O1 10.1016/j.ejmech.2012.09.049
44431547 94918 0 None -34 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234681 94918 0 None -34 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
1070749 146390 2 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 261 3 2 3 1.8 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccccc1 10.1021/acs.jmedchem.5b01528
CHEMBL3797529 146390 2 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 261 3 2 3 1.8 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccccc1 10.1021/acs.jmedchem.5b01528
10627155 43993 0 None -151 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 585 8 2 8 3.2 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(=O)OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145338 43993 0 None -151 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 585 8 2 8 3.2 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(=O)OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
44431173 99577 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 519 5 0 5 4.8 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4c(F)c(F)c(F)c(F)c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
CHEMBL243690 99577 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [125]HEAT from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 519 5 0 5 4.8 CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4c(F)c(F)c(F)c(F)c4C3=O)CC2)CC1 10.1016/j.bmcl.2006.12.111
155542075 183398 0 None 1 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 9 1 4 4.4 c1ccc(OCCNCCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4520390 183398 0 None 1 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 9 1 4 4.4 c1ccc(OCCNCCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4597826 183398 0 None 1 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 9 1 4 4.4 c1ccc(OCCNCCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
53328316 70165 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 449 9 0 5 3.9 COc1ccccc1N1CCN(CCCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796036 70165 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 449 9 0 5 3.9 COc1ccccc1N1CCN(CCCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
10775000 114171 2 None -8 5 Rat 7.5 pKi = 7.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 214 1 2 2 2.6 Oc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL317912 114171 2 None -8 5 Rat 7.5 pKi = 7.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 214 1 2 2 2.6 Oc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
9900133 15757 0 None -33 4 Rat 5.5 pKi = 5.5 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 271 2 2 3 3.1 COC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL109827 15757 0 None -33 4 Rat 5.5 pKi = 5.5 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 271 2 2 3 3.1 COC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
9900133 15757 0 None -33 4 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 271 2 2 3 3.1 COC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL109827 15757 0 None -33 4 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 271 2 2 3 3.1 COC(=O)Nc1cccc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
9796667 116243 0 None -9 2 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 309 3 2 3 2.4 CS(=O)(=O)Nc1ccc(F)c2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL322042 116243 0 None -9 2 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 309 3 2 3 2.4 CS(=O)(=O)Nc1ccc(F)c2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
11140345 210950 0 None -2 6 Human 6.5 pKi = 6.5 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 239 4 2 4 2.0 CSc1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70692 210950 0 None -2 6 Human 6.5 pKi = 6.5 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 239 4 2 4 2.0 CSc1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
10531766 213776 0 None -269 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 607 9 2 7 6.3 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
CHEMBL91415 213776 0 None -269 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 607 9 2 7 6.3 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
137640201 163740 2 None -239 13 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 362 6 0 2 4.3 O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1 10.1021/acs.jmedchem.8b00265
CHEMBL4072818 163740 2 None -239 13 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 362 6 0 2 4.3 O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1 10.1021/acs.jmedchem.8b00265
9960497 123853 0 None -91 6 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
CHEMBL3392246 123853 0 None -91 6 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
18738412 212188 0 None -2 3 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 365 6 1 6 3.3 OCc1cc(CN2CCN(c3ccccc3Oc3ccccc3)CC2)on1 10.1016/s0960-894x(02)00436-5
CHEMBL80125 212188 0 None -2 3 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 365 6 1 6 3.3 OCc1cc(CN2CCN(c3ccccc3Oc3ccccc3)CC2)on1 10.1016/s0960-894x(02)00436-5
15853467 214913 0 None -93 6 Human 6.5 pKi = 6.5 Binding
Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)
ChEMBL 692 16 3 8 5.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1 10.1016/s0960-894x(99)00484-9
CHEMBL98063 214913 0 None -93 6 Human 6.5 pKi = 6.5 Binding
Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)
ChEMBL 692 16 3 8 5.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1 10.1016/s0960-894x(99)00484-9
151779 201483 2 None -2 4 Human 6.5 pKi = 6.5 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 384 10 2 4 6.3 c1ccc2c(NCCCCCCCNc3ccnc4ccccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL533979 201483 2 None -2 4 Human 6.5 pKi = 6.5 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 384 10 2 4 6.3 c1ccc2c(NCCCCCCCNc3ccnc4ccccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
44420418 90205 0 None 13 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 474 4 1 6 4.0 O=c1[nH]c2c(sc3ccccc32)c(=O)n1CCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL219718 90205 0 None 13 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 474 4 1 6 4.0 O=c1[nH]c2c(sc3ccccc32)c(=O)n1CCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2006.09.034
151779 201483 2 None -2 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 384 10 2 4 6.3 c1ccc2c(NCCCCCCCNc3ccnc4ccccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL533979 201483 2 None -2 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 384 10 2 4 6.3 c1ccc2c(NCCCCCCCNc3ccnc4ccccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
44431564 94417 0 None -34 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 501 8 1 6 4.2 COc1ccc(C)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233623 94417 0 None -34 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 501 8 1 6 4.2 COc1ccc(C)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
44300087 103196 0 None -67 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.5 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL262002 103196 0 None -67 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.5 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
10530552 40019 0 None -51 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 543 7 3 7 3.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL141821 40019 0 None -51 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 543 7 3 7 3.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
10745380 45565 0 None -309 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 557 8 2 7 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL146654 45565 0 None -309 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 557 8 2 7 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
132266 8061 12 None -5 9 Human 7.5 pKi = 7.5 Binding
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm960697s
486 8061 12 None -5 9 Human 7.5 pKi = 7.5 Binding
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm960697s
CHEMBL423294 8061 12 None -5 9 Human 7.5 pKi = 7.5 Binding
Binding affinity was tested on cloned rat Alpha-1D adrenergic receptorBinding affinity was tested on cloned rat Alpha-1D adrenergic receptor
ChEMBL 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 10.1021/jm960697s
25132566 194102 0 None -5 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@@H]1COC[C@@H](c2ccccc2)O1 10.1021/jm800461k
CHEMBL493041 194102 0 None -5 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@@H]1COC[C@@H](c2ccccc2)O1 10.1021/jm800461k
56946472 78286 0 None -15 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 373 8 1 3 4.8 c1ccc(OCCNCC2CCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm200421e
CHEMBL1946778 78286 0 None -15 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 373 8 1 3 4.8 c1ccc(OCCNCC2CCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm200421e
CHEMBL1962753 78286 0 None -15 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 373 8 1 3 4.8 c1ccc(OCCNCC2CCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm200421e
9804599 108477 0 None -25 3 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 430 7 1 6 1.8 O=c1cc[nH]c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
CHEMBL299452 108477 0 None -25 3 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 430 7 1 6 1.8 O=c1cc[nH]c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
44298671 169955 0 None -19 3 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 460 8 1 7 1.8 COc1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
CHEMBL418112 169955 0 None -19 3 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 460 8 1 7 1.8 COc1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
15840661 206241 0 None -31 3 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 432 7 1 5 2.2 O=C1CCNC(=O)N1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
CHEMBL59153 206241 0 None -31 3 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 432 7 1 5 2.2 O=C1CCNC(=O)N1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
145947915 174509 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 431 6 1 6 2.3 CS(=O)(=O)c1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4213907 174509 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 431 6 1 6 2.3 CS(=O)(=O)c1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4302725 174509 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 431 6 1 6 2.3 CS(=O)(=O)c1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
9985476 44058 0 None -1584 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 570 8 3 7 2.5 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145394 44058 0 None -1584 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 570 8 3 7 2.5 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
136806211 214462 0 None -72 3 Human 6.5 pKi = 6.5 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 650 14 4 7 5.0 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCN)N1 10.1016/s0960-894x(99)00484-9
44328738 214462 0 None -72 3 Human 6.5 pKi = 6.5 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 650 14 4 7 5.0 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL95434 214462 0 None -72 3 Human 6.5 pKi = 6.5 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 650 14 4 7 5.0 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCN)N1 10.1016/s0960-894x(99)00484-9
44307780 109114 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 431 5 0 8 3.1 COc1ccccc1N1CCN(Cn2nc(-c3ccccc3)c3c(C)onc3c2=O)CC1 10.1021/jm0307741
CHEMBL303681 109114 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 431 5 0 8 3.1 COc1ccccc1N1CCN(Cn2nc(-c3ccccc3)c3c(C)onc3c2=O)CC1 10.1021/jm0307741
10508332 112768 0 None -213 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 638 11 2 8 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])c(OC)c1 10.1021/jm980077m
CHEMBL313160 112768 0 None -213 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 638 11 2 8 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])c(OC)c1 10.1021/jm980077m
10627021 113872 0 None -229 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 577 9 2 5 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C)cc1 10.1021/jm980077m
CHEMBL315914 113872 0 None -229 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 577 9 2 5 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C)cc1 10.1021/jm980077m
155517137 176918 0 None -11 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNCC2OCCOC2(c2ccccc2)c2ccccc2)cc1 10.1016/j.ejmech.2019.02.056
CHEMBL4444133 176918 0 None -11 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNCC2OCCOC2(c2ccccc2)c2ccccc2)cc1 10.1016/j.ejmech.2019.02.056
11857711 92401 0 None -8 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 506 7 1 4 5.5 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.098
CHEMBL228332 92401 0 None -8 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 506 7 1 4 5.5 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.098
49781676 24644 0 None -36 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 400 2 0 3 5.7 Cc1ccccc1-c1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
CHEMBL1259062 24644 0 None -36 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 400 2 0 3 5.7 Cc1ccccc1-c1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 10.1021/jm100652h
10531157 44576 0 None -3162 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 572 8 2 8 3.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145843 44576 0 None -3162 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 572 8 2 8 3.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
46934791 23462 0 None -10 4 Human 7.5 pKi = 7.5 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 479 7 0 7 2.6 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242818 23462 0 None -10 4 Human 7.5 pKi = 7.5 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 479 7 0 7 2.6 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
134133829 150603 0 None -14 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 337 7 1 5 3.5 COc1ccccc1OCCNCC1CSC2(CCCCC2)O1 10.1016/j.ejmech.2016.09.050
CHEMBL3901382 150603 0 None -14 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 337 7 1 5 3.5 COc1ccccc1OCCNCC1CSC2(CCCCC2)O1 10.1016/j.ejmech.2016.09.050
10526419 205827 0 None -8 3 Rat 7.5 pKi = 7.5 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 425 7 2 6 2.7 COc1cc(N)c(C(=O)NCCN2C[C@@H]3CCc4c(OC)cccc4[C@@H]3C2)cc1OC 10.1021/jm000541z
CHEMBL58612 205827 0 None -8 3 Rat 7.5 pKi = 7.5 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 425 7 2 6 2.7 COc1cc(N)c(C(=O)NCCN2C[C@@H]3CCc4c(OC)cccc4[C@@H]3C2)cc1OC 10.1021/jm000541z
44318081 170092 0 None -3 3 Human 6.5 pKi = 6.5 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 504 8 0 6 3.9 CCOC(=O)[C@H]1CN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC[C@@H]1c1ccccc1 10.1016/s0960-894x(98)00451-x
CHEMBL418926 170092 0 None -3 3 Human 6.5 pKi = 6.5 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 504 8 0 6 3.9 CCOC(=O)[C@H]1CN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC[C@@H]1c1ccccc1 10.1016/s0960-894x(98)00451-x
44300111 107637 0 None -794 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 583 7 2 7 4.0 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCC(c4ccccn4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL293515 107637 0 None -794 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 583 7 2 7 4.0 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCC(c4ccccn4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
10793023 128300 0 None -173 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 562 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1cccc(C)c1 10.1021/jm990200p
CHEMBL358489 128300 0 None -173 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 562 8 2 7 3.8 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1cccc(C)c1 10.1021/jm990200p
44289026 173165 0 None -144 3 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 533 8 1 3 6.5 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3C(F)(F)F)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL42763 173165 0 None -144 3 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 533 8 1 3 6.5 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3C(F)(F)F)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
10651654 118260 0 None -173 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 631 9 2 5 7.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)c(Cl)c1 10.1021/jm980077m
CHEMBL327712 118260 0 None -173 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 631 9 2 5 7.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)c(Cl)c1 10.1021/jm980077m
71449516 91379 0 None -18 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 361 8 2 7 2.2 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(O)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153552 91379 0 None -18 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 361 8 2 7 2.2 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(O)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2221146 91379 0 None -18 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 361 8 2 7 2.2 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(O)c2O1 10.1016/j.ejmech.2012.09.049
11742585 170127 0 None -1 2 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 415 5 1 6 2.5 CS(=O)(=O)Nc1ccc2c(c1)OC1(CCN(CCc3ccccn3)CC1)CC2=O 10.1016/s0960-894x(98)00732-x
CHEMBL419164 170127 0 None -1 2 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 415 5 1 6 2.5 CS(=O)(=O)Nc1ccc2c(c1)OC1(CCN(CCc3ccccn3)CC1)CC2=O 10.1016/s0960-894x(98)00732-x
50985821 182997 31 None -2 3 Human 5.5 pKi = 5.5 Binding
Binding affinity to alpha1D receptor (unknown origin) by radioligand displacement assayBinding affinity to alpha1D receptor (unknown origin) by radioligand displacement assay
ChEMBL 474 5 2 5 6.2 N=c1c2c(-c3ccccc3)c(-c3ccccc3)n(Cc3ccccc3)c2ncn1[C@H]1CC[C@H](O)CC1 10.1021/acs.jmedchem.2c00204
CHEMBL4594433 182997 31 None -2 3 Human 5.5 pKi = 5.5 Binding
Binding affinity to alpha1D receptor (unknown origin) by radioligand displacement assayBinding affinity to alpha1D receptor (unknown origin) by radioligand displacement assay
ChEMBL 474 5 2 5 6.2 N=c1c2c(-c3ccccc3)c(-c3ccccc3)n(Cc3ccccc3)c2ncn1[C@H]1CC[C@H](O)CC1 10.1021/acs.jmedchem.2c00204
122295 16640 7 None -1 9 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 279 3 0 2 3.7 CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 10.1021/jm00019a001
CHEMBL114166 16640 7 None -1 9 Human 7.5 pKi = 7.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 279 3 0 2 3.7 CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 10.1021/jm00019a001
53328314 70163 0 None -2 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 439 7 0 4 4.2 O=C1CC(c2ccccc2)CC(=O)N1CCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796034 70163 0 None -2 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 439 7 0 4 4.2 O=C1CC(c2ccccc2)CC(=O)N1CCCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
145949210 169528 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 459 5 2 9 2.8 COc1cc2nc(N3CCC[C@@H](NC4=CC(=O)c5ccccc5C4=O)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
CHEMBL4171491 169528 0 None -1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 459 5 2 9 2.8 COc1cc2nc(N3CCC[C@@H](NC4=CC(=O)c5ccccc5C4=O)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
10507500 128472 0 None -1659 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 582 6 2 7 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)OC(=O)Cc2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL358785 128472 0 None -1659 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 582 6 2 7 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)OC(=O)Cc2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
44288740 108132 0 None -117 3 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 437 8 1 3 4.9 N#CC1(c2ccccc2)CCN(CCCNC(=O)C(c2ccccc2)c2ccccc2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL296965 108132 0 None -117 3 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 437 8 1 3 4.9 N#CC1(c2ccccc2)CCN(CCCNC(=O)C(c2ccccc2)c2ccccc2)CC1 10.1016/s0960-894x(00)00307-3
44288810 176241 0 None -5 3 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 483 9 2 3 4.5 Cc1ccc(C(C(=O)NCCCN2CCC(C(N)=O)(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL44288 176241 0 None -5 3 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 483 9 2 3 4.5 Cc1ccc(C(C(=O)NCCCN2CCC(C(N)=O)(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
180707 121912 2 None -12 4 Human 6.5 pKi = 6.5 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 314 5 2 4 4.3 c1ccc2c(NCCNc3ccnc4ccccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343975 121912 2 None -12 4 Human 6.5 pKi = 6.5 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 314 5 2 4 4.3 c1ccc2c(NCCNc3ccnc4ccccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
10793963 106448 0 None -23 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 622 11 2 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL284470 106448 0 None -23 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 622 11 2 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
124 9755 47 None -338 32 Rat 6.5 pKi = 6.5 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
2032 9755 47 None -338 32 Rat 6.5 pKi = 6.5 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
4636 9755 47 None -338 32 Rat 6.5 pKi = 6.5 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
CHEMBL762 9755 47 None -338 32 Rat 6.5 pKi = 6.5 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
DB00935 9755 47 None -338 32 Rat 6.5 pKi = 6.5 Binding
Binding affinity towards rat clonal Alpha-1D adrenergic receptorBinding affinity towards rat clonal Alpha-1D adrenergic receptor
ChEMBL 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 10.1021/jm960354u
180707 121912 2 None -12 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 314 5 2 4 4.3 c1ccc2c(NCCNc3ccnc4ccccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343975 121912 2 None -12 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 314 5 2 4 4.3 c1ccc2c(NCCNc3ccnc4ccccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
46846073 12572 0 None -151 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 451 9 1 4 5.6 c1ccc(-c2ccccc2OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.bmcl.2010.01.030
CHEMBL1078772 12572 0 None -151 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 451 9 1 4 5.6 c1ccc(-c2ccccc2OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.bmcl.2010.01.030
9944467 16023 0 None -19 4 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 309 2 2 2 3.4 O=C(Nc1cccc2c1CCCC2c1c[nH]cn1)C(F)(F)F 10.1021/jm030551a
CHEMBL110751 16023 0 None -19 4 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 309 2 2 2 3.4 O=C(Nc1cccc2c1CCCC2c1c[nH]cn1)C(F)(F)F 10.1021/jm030551a
CHEMBL4535474 220767 39 None -2 6 Human 6.5 pKi = 6.5 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000320b ADRA1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000320b ADRA1D
ChEMBL None None None CNCc1ccccc1-c1csc([C@@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 10.6019/CHEMBL5212743
11281005 18615 0 None -13 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 399 8 1 6 3.4 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL1182191 18615 0 None -13 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 399 8 1 6 3.4 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL218079 18615 0 None -13 6 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 399 8 1 6 3.4 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
11347303 118157 0 None -15 5 Rat 6.5 pKi = 6.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1ccc2c(c1)C(c1c[nH]cn1)CCC2 10.1021/jm030551a
CHEMBL327116 118157 0 None -15 5 Rat 6.5 pKi = 6.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 4 2 3 2.6 CCS(=O)(=O)Nc1ccc2c(c1)C(c1c[nH]cn1)CCC2 10.1021/jm030551a
20750645 109084 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 346 6 1 5 3.4 CC(C)Oc1ccccc1N1CCN(Cc2cc(CO)cs2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL303485 109084 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 346 6 1 5 3.4 CC(C)Oc1ccccc1N1CCN(Cc2cc(CO)cs2)CC1 10.1016/s0960-894x(02)00347-5
11519153 92394 0 None -3 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 514 9 1 6 4.7 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
11519153 92394 0 None -3 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 514 9 1 6 4.7 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL228278 92394 0 None -3 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 514 9 1 6 4.7 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL228278 92394 0 None -3 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 514 9 1 6 4.7 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
506 9032 39 None -6 6 Human 7.5 pKi = 7.5 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 522 6 2 9 3.0 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H](C1)C(=O)NC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm980053f
6603904 9032 39 None -6 6 Human 7.5 pKi = 7.5 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 522 6 2 9 3.0 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H](C1)C(=O)NC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm980053f
CHEMBL19476 9032 39 None -6 6 Human 7.5 pKi = 7.5 Binding
Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 522 6 2 9 3.0 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H](C1)C(=O)NC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm980053f
10745901 44238 0 None -1698 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 586 8 2 8 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])C[C@@H]2C)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145547 44238 0 None -1698 3 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 586 8 2 8 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])C[C@@H]2C)C1c1ccc(F)c(F)c1 10.1021/jm990202+
10949698 212066 0 None -38 4 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 413 8 1 8 1.9 COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL79161 212066 0 None -38 4 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 413 8 1 8 1.9 COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 10.1021/jm0009336
44460477 212186 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 432 7 0 6 3.9 O=C1CCCN1Cc1cc(CN2CCN(c3ccccc3Oc3ccccc3)CC2)on1 10.1016/s0960-894x(02)00436-5
CHEMBL80109 212186 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 432 7 0 6 3.9 O=C1CCCN1Cc1cc(CN2CCN(c3ccccc3Oc3ccccc3)CC2)on1 10.1016/s0960-894x(02)00436-5
134149777 155290 0 None -37 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 353 7 1 5 4.2 COc1ccccc1OCCNCC1CSC2(CCCCC2)S1 10.1016/j.ejmech.2016.09.050
CHEMBL3938383 155290 0 None -37 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 353 7 1 5 4.2 COc1ccccc1OCCNCC1CSC2(CCCCC2)S1 10.1016/j.ejmech.2016.09.050
181743 185351 5 None -169 22 Human 6.5 pKi = 6.5 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
CHEMBL467094 185351 5 None -169 22 Human 6.5 pKi = 6.5 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4 10.1016/j.bmcl.2009.11.053
44295192 108499 0 None -380 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 574 7 2 10 2.4 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc3nonc3c2)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL299539 108499 0 None -380 3 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 574 7 2 10 2.4 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc3nonc3c2)CC1 10.1016/s0960-894x(99)00653-8
10673657 213512 0 None -2818 3 Human 6.5 pKi = 6.5 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 525 7 2 4 4.3 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1C 10.1021/jm990612y
CHEMBL89927 213512 0 None -2818 3 Human 6.5 pKi = 6.5 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 525 7 2 4 4.3 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1C 10.1021/jm990612y
10099811 127801 4 None -912 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990202+
CHEMBL356584 127801 4 None -912 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990202+
10745664 128794 0 None -28 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 572 8 2 8 3.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3cccc([N+](=O)[O-])c3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL359433 128794 0 None -28 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 572 8 2 8 3.3 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3cccc([N+](=O)[O-])c3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
10371061 43475 0 None -1905 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL144925 43475 0 None -1905 3 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
10099811 127801 4 None -912 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL356584 127801 4 None -912 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
44288741 175626 0 None -45 2 Human 5.5 pKi = 5.5 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 408 8 1 4 3.3 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)Cc2ccc(C)cc2)CC1 10.1016/s0960-894x(01)00320-1
CHEMBL43799 175626 0 None -45 2 Human 5.5 pKi = 5.5 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 408 8 1 4 3.3 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)Cc2ccc(C)cc2)CC1 10.1016/s0960-894x(01)00320-1
44288741 175626 0 None -45 2 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 408 8 1 4 3.3 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)Cc2ccc(C)cc2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL43799 175626 0 None -45 2 Human 5.5 pKi = 5.5 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 408 8 1 4 3.3 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)Cc2ccc(C)cc2)CC1 10.1016/s0960-894x(00)00307-3
19085921 111686 0 None -3 3 Human 5.5 pKi = 5.5 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 513 7 0 9 2.6 COC(=O)c1ccc2c(c1)oc(=O)n2C1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL311290 111686 0 None -3 3 Human 5.5 pKi = 5.5 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 513 7 0 9 2.6 COC(=O)c1ccc2c(c1)oc(=O)n2C1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/s0960-894x(98)00446-6
9894818 105701 0 None -138 7 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm00019a001
CHEMBL279436 105701 0 None -138 7 Human 6.5 pKi = 6.5 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm00019a001
10818003 113198 0 None -6 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 649 12 3 6 6.2 CC(C)C1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C(C)C)N1 10.1021/jm980077m
CHEMBL313953 113198 0 None -6 6 Human 6.5 pKi = 6.5 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 649 12 3 6 6.2 CC(C)C1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C(C)C)N1 10.1021/jm980077m
11090351 170170 0 None -13 4 Human 5.5 pKi = 5.5 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL419448 170170 0 None -13 4 Human 5.5 pKi = 5.5 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1c(F)cccc1NCC1=NCCN1 10.1021/jm000542r
136 10065 32 None -54 16 Rat 7.5 pKi = 7.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
223 10065 32 None -54 16 Rat 7.5 pKi = 7.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
643606 10065 32 None -54 16 Rat 7.5 pKi = 7.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
CHEMBL10347 10065 32 None -54 16 Rat 7.5 pKi = 7.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
3584 10549 64 None -1 14 Rat 7.5 pKi = 7.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
5401 10549 64 None -1 14 Rat 7.5 pKi = 7.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
7302 10549 64 None -1 14 Rat 7.5 pKi = 7.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
CHEMBL611 10549 64 None -1 14 Rat 7.5 pKi = 7.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
DB01162 10549 64 None -1 14 Rat 7.5 pKi = 7.5 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 10.1021/jm00018a001
44431553 94261 0 None -1 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 525 7 1 5 4.9 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233416 94261 0 None -1 4 Human 7.5 pKi = 7.5 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 525 7 1 5 4.9 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccc(C(F)(F)F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.008
11393666 199765 0 None -89 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
CHEMBL5201983 199765 0 None -89 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
CHEMBL5222597 199765 0 None -89 19 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysis
ChEMBL 340 2 1 2 4.6 CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1 10.1016/j.bmcl.2022.128879
11191047 208596 0 None 7 3 Rat 7.5 pKi = 7.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 490 7 0 6 3.2 COc1ccccc1N1CCN(CCN2C(=O)CC3(CCN(Cc4ccccc4)CC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL60699 208596 0 None 7 3 Rat 7.5 pKi = 7.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 490 7 0 6 3.2 COc1ccccc1N1CCN(CCN2C(=O)CC3(CCN(Cc4ccccc4)CC3)CC2=O)CC1 10.1021/jm030944+
10928161 11013 0 None 269 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 431 5 2 5 3.1 CC(C)c1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 10.1016/j.ejmech.2011.03.054
CHEMBL100434 11013 0 None 269 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 431 5 2 5 3.1 CC(C)c1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 10.1016/j.ejmech.2011.03.054
118716723 121795 0 None -2 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 4 1 6 2.5 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)NC(C)(C)C)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342876 121795 0 None -2 4 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 4 1 6 2.5 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)NC(C)(C)C)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
11440679 204853 0 None 16 2 Rat 7.5 pKi = 7.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 389 4 0 4 3.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm030944+
CHEMBL57425 204853 0 None 16 2 Rat 7.5 pKi = 7.5 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 389 4 0 4 3.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(Cl)cc2)CC1 10.1021/jm030944+
10099811 127801 4 None -912 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
CHEMBL356584 127801 4 None -912 4 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
19085820 212583 0 None -2691 3 Human 6.5 pKi = 6.5 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 0 9 2.8 O=C1c2cc([N+](=O)[O-])ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL83226 212583 0 None -2691 3 Human 6.5 pKi = 6.5 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 0 9 2.8 O=C1c2cc([N+](=O)[O-])ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
132060770 169418 0 None -57 10 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting method
ChEMBL 451 7 0 6 3.5 CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 10.1016/j.ejmech.2018.02.024
CHEMBL4169689 169418 0 None -57 10 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Prazosin from human adrenergic alpha1D receptor after 90 mins by microbeta scintillation counting method
ChEMBL 451 7 0 6 3.5 CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1 10.1016/j.ejmech.2018.02.024
46882088 12599 0 None -46 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 435 10 1 6 4.0 COc1cccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)c1OC 10.1016/j.bmcl.2010.01.030
CHEMBL1079066 12599 0 None -46 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 435 10 1 6 4.0 COc1cccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)c1OC 10.1016/j.bmcl.2010.01.030
25132217 179382 0 None -13 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 313 7 1 4 2.8 c1ccc(OCCNC[C@@H]2CO[C@H](c3ccccc3)CO2)cc1 10.1021/jm800461k
CHEMBL449057 179382 0 None -13 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 313 7 1 4 2.8 c1ccc(OCCNC[C@@H]2CO[C@H](c3ccccc3)CO2)cc1 10.1021/jm800461k
11346205 16048 0 None 8 2 Rat 6.5 pKi = 6.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 268 4 3 5 0.8 CCS(=O)(=O)Nc1cccc(NC2=NCCN2)c1 10.1021/jm030551a
CHEMBL110852 16048 0 None 8 2 Rat 6.5 pKi = 6.5 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 268 4 3 5 0.8 CCS(=O)(=O)Nc1cccc(NC2=NCCN2)c1 10.1021/jm030551a
44431554 173457 0 None -28 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL428197 173457 0 None -28 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
11857792 150681 0 None -3 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 560 8 1 5 5.8 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1 10.1016/j.bmcl.2007.04.098
CHEMBL390192 150681 0 None -3 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 560 8 1 5 5.8 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1 10.1016/j.bmcl.2007.04.098
44289321 168747 0 None -33 3 Human 7.4 pKi = 7.4 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 455 8 1 3 5.1 Cc1ccc(C(C(=O)NCCCN2CCN(c3ccccc3C)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL415887 168747 0 None -33 3 Human 7.4 pKi = 7.4 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 455 8 1 3 5.1 Cc1ccc(C(C(=O)NCCCN2CCN(c3ccccc3C)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
44289047 107159 0 None -134 3 Human 5.4 pKi = 5.4 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 441 8 1 3 5.2 Cc1ccc(C(C(=O)NCCCN2CCC(c3ccccn3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL289916 107159 0 None -134 3 Human 5.4 pKi = 5.4 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 441 8 1 3 5.2 Cc1ccc(C(C(=O)NCCCN2CCC(c3ccccn3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
11994671 18601 0 None -1 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cc(-c2ccccc2)ccc1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182138 18601 0 None -1 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cc(-c2ccccc2)ccc1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL214506 18601 0 None -1 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1cc(-c2ccccc2)ccc1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
10132012 116522 0 None -7 2 Rat 6.4 pKi = 6.4 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 339 4 2 3 3.3 CCS(=O)(=O)Nc1cc(Cl)cc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL323004 116522 0 None -7 2 Rat 6.4 pKi = 6.4 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 339 4 2 3 3.3 CCS(=O)(=O)Nc1cc(Cl)cc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
9796525 16179 0 None -7 3 Rat 5.4 pKi = 5.4 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 305 3 1 4 2.3 Cn1cnc(C2CCCc3c(NS(C)(=O)=O)cccc32)c1 10.1007/s00044-004-0020-z
CHEMBL111584 16179 0 None -7 3 Rat 5.4 pKi = 5.4 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 305 3 1 4 2.3 Cn1cnc(C2CCCc3c(NS(C)(=O)=O)cccc32)c1 10.1007/s00044-004-0020-z
9880254 16073 0 None -43 2 Rat 5.4 pKi = 5.4 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 323 4 2 3 2.8 CCS(=O)(=O)Nc1cc(F)cc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL110975 16073 0 None -43 2 Rat 5.4 pKi = 5.4 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 323 4 2 3 2.8 CCS(=O)(=O)Nc1cc(F)cc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
9798656 19662 0 None -24 3 Human 7.4 pKi = 7.4 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 353 7 1 2 5.0 c1ccc2c(C3CCN(CCCCCN4CCCCC4)CC3)c[nH]c2c1 10.1016/j.bmcl.2006.05.002
CHEMBL1188902 19662 0 None -24 3 Human 7.4 pKi = 7.4 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 353 7 1 2 5.0 c1ccc2c(C3CCN(CCCCCN4CCCCC4)CC3)c[nH]c2c1 10.1016/j.bmcl.2006.05.002
CHEMBL537651 19662 0 None -24 3 Human 7.4 pKi = 7.4 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 353 7 1 2 5.0 c1ccc2c(C3CCN(CCCCCN4CCCCC4)CC3)c[nH]c2c1 10.1016/j.bmcl.2006.05.002
10530491 109382 0 None -234 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 540 9 1 6 4.5 Cc1ccc(N2C(=O)c3ccc(C(=O)NCCCN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
CHEMBL304132 109382 0 None -234 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 540 9 1 6 4.5 Cc1ccc(N2C(=O)c3ccc(C(=O)NCCCN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
10554913 44120 0 None -52 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 561 7 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3cccc(Cl)c3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145443 44120 0 None -52 3 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 561 7 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3cccc(Cl)c3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
145951352 169539 0 None 1 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 397 5 2 8 2.2 COc1cc2nc(N3CCC[C@@H](NC(=O)c4ccco4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
CHEMBL4171710 169539 0 None 1 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 397 5 2 8 2.2 COc1cc2nc(N3CCC[C@@H](NC(=O)c4ccco4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
118716703 121774 0 None 1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 347 4 1 6 1.3 COc1ccccc1N1CCN(CC2COC3(CCNCC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342856 121774 0 None 1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 347 4 1 6 1.3 COc1ccccc1N1CCN(CC2COC3(CCNCC3)O2)CC1 10.1016/j.ejmech.2014.09.070
10407753 204535 1 None 1 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 385 5 0 5 2.5 COc1ccc(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)cc1 10.1021/jm030944+
CHEMBL57168 204535 1 None 1 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 385 5 0 5 2.5 COc1ccc(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)cc1 10.1021/jm030944+
10626610 43526 0 None -371 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 556 8 2 6 4.2 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL144965 43526 0 None -371 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 556 8 2 6 4.2 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
118717459 121919 0 None -2 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 444 12 2 6 6.3 COc1ccc2nccc(NCCCCCCCNc3ccnc4ccc(OC)cc34)c2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343981 121919 0 None -2 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 444 12 2 6 6.3 COc1ccc2nccc(NCCCCCCCNc3ccnc4ccc(OC)cc34)c2c1 10.1016/j.bmc.2014.09.017
9887378 105181 4 None -40 3 Human 6.4 pKi = 6.4 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 402 8 1 5 1.7 CC(C)Oc1ccccc1N1CCN(CCNC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL275469 105181 4 None -40 3 Human 6.4 pKi = 6.4 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 402 8 1 5 1.7 CC(C)Oc1ccccc1N1CCN(CCNC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
118717459 121919 0 None -2 4 Human 6.4 pKi = 6.4 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 444 12 2 6 6.3 COc1ccc2nccc(NCCCCCCCNc3ccnc4ccc(OC)cc34)c2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343981 121919 0 None -2 4 Human 6.4 pKi = 6.4 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 444 12 2 6 6.3 COc1ccc2nccc(NCCCCCCCNc3ccnc4ccc(OC)cc34)c2c1 10.1016/j.bmc.2014.09.017
2247 7293 81 None -31 42 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 7293 81 None -31 42 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 7293 81 None -31 42 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 7293 81 None -31 42 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 7293 81 None -31 42 Human 6.4 pKi = 6.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
44431587 173931 0 None -3 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 565 8 1 6 4.7 COc1ccc(Br)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL429076 173931 0 None -3 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 565 8 1 6 4.7 COc1ccc(Br)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
9808529 210651 0 None -20 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 587 10 2 9 3.1 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc([N+](=O)[O-])cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL68746 210651 0 None -20 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 587 10 2 9 3.1 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc([N+](=O)[O-])cc2)C3=O)CC1 10.1021/jm9905918
145947248 174413 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1ccc2c(c1)S(=O)(=O)CCC2NCCOc1cc(F)ccc1F 10.1016/j.ejmech.2017.07.071
CHEMBL4214419 174413 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1ccc2c(c1)S(=O)(=O)CCC2NCCOc1cc(F)ccc1F 10.1016/j.ejmech.2017.07.071
CHEMBL4301553 174413 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1ccc2c(c1)S(=O)(=O)CCC2NCCOc1cc(F)ccc1F 10.1016/j.ejmech.2017.07.071
53328315 70164 0 None -1 3 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 469 8 0 5 4.2 COc1ccc(Cl)cc1N1CCN(CCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796035 70164 0 None -1 3 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 469 8 0 5 4.2 COc1ccc(Cl)cc1N1CCN(CCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
134137025 149516 0 None -7 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 362 4 0 5 3.6 COc1ccccc1N1CCN(CC2CSC3(CCCCC3)O2)CC1 10.1016/j.ejmech.2016.09.050
CHEMBL3892434 149516 0 None -7 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 362 4 0 5 3.6 COc1ccccc1N1CCN(CC2CSC3(CCCCC3)O2)CC1 10.1016/j.ejmech.2016.09.050
44328654 113962 0 None -100 6 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 663 14 3 6 6.7 CCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1 10.1016/s0960-894x(99)00484-9
CHEMBL316495 113962 0 None -100 6 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 663 14 3 6 6.7 CCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1 10.1016/s0960-894x(99)00484-9
44328739 214430 0 None -3 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 691 16 3 6 7.5 CCCCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1 10.1016/s0960-894x(99)00484-9
CHEMBL95263 214430 0 None -3 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 691 16 3 6 7.5 CCCCCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCC)=C(CC)N1 10.1016/s0960-894x(99)00484-9
10674896 213423 0 None -208 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 588 9 2 6 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C#N)cc1 10.1021/jm980077m
CHEMBL89243 213423 0 None -208 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 588 9 2 6 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(C#N)cc1 10.1021/jm980077m
44361064 38389 0 None -14 6 Rat 6.4 pKi = 6.4 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 338 7 2 4 4.5 N=CCC(O)CC1CCN(c2ccccc2Oc2ccccc2)CC1 10.1021/jm960510x
CHEMBL140450 38389 0 None -14 6 Rat 6.4 pKi = 6.4 Binding
Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.
ChEMBL 338 7 2 4 4.5 N=CCC(O)CC1CCN(c2ccccc2Oc2ccccc2)CC1 10.1021/jm960510x
9816461 17491 7 None -6 4 Human 5.4 pKi = 5.4 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL117094 17491 7 None -6 4 Human 5.4 pKi = 5.4 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL544290 17491 7 None -6 4 Human 5.4 pKi = 5.4 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1 10.1021/jm000542r
10364538 11158 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 415 5 1 6 2.5 CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3ccccn3)CC1)O2 10.1016/s0960-894x(98)00732-x
CHEMBL101322 11158 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 415 5 1 6 2.5 CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3ccccn3)CC1)O2 10.1016/s0960-894x(98)00732-x
CHEMBL1204312 11158 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 415 5 1 6 2.5 CS(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3ccccn3)CC1)O2 10.1016/s0960-894x(98)00732-x
11784634 43288 0 None -1 3 Human 6.4 pKi = 6.4 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 468 10 2 8 3.7 COc1cc2nc3c(c(O)c2cc1OC)CCC(CNCCOc1c(OC)cccc1OC)C3 10.1021/jm030952q
CHEMBL144779 43288 0 None -1 3 Human 6.4 pKi = 6.4 Binding
Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKiBinding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi
ChEMBL 468 10 2 8 3.7 COc1cc2nc3c(c(O)c2cc1OC)CCC(CNCCOc1c(OC)cccc1OC)C3 10.1021/jm030952q
53328313 70161 0 None -2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 455 7 0 5 3.8 COc1ccc(Cl)cc1N1CCN(CCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796032 70161 0 None -2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 455 7 0 5 3.8 COc1ccc(Cl)cc1N1CCN(CCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
56946575 78302 0 None -37 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 385 8 1 3 4.6 O=C1C(CNCCOc2ccccc2)CCC1(c1ccccc1)c1ccccc1 10.1021/jm200421e
CHEMBL1946781 78302 0 None -37 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 385 8 1 3 4.6 O=C1C(CNCCOc2ccccc2)CCC1(c1ccccc1)c1ccccc1 10.1021/jm200421e
CHEMBL1962871 78302 0 None -37 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 385 8 1 3 4.6 O=C1C(CNCCOc2ccccc2)CCC1(c1ccccc1)c1ccccc1 10.1021/jm200421e
59151610 146637 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 295 3 2 3 2.4 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccccc1Cl 10.1021/acs.jmedchem.5b01528
CHEMBL3799219 146637 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 295 3 2 3 2.4 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccccc1Cl 10.1021/acs.jmedchem.5b01528
44299974 108671 0 None -89 3 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 608 7 2 8 3.4 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL300821 108671 0 None -89 3 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 608 7 2 8 3.4 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
10516365 66221 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 272 3 1 3 3.0 COC(c1c[nH]cn1)c1sccc1Br 10.1021/jm0003891
CHEMBL171196 66221 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 272 3 1 3 3.0 COC(c1c[nH]cn1)c1sccc1Br 10.1021/jm0003891
CHEMBL1744266 66221 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 272 3 1 3 3.0 COC(c1c[nH]cn1)c1sccc1Br 10.1021/jm0003891
11431037 107715 0 None 20 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 457 4 0 4 4.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(C(F)(F)F)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL294023 107715 0 None 20 2 Rat 7.4 pKi = 7.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 457 4 0 4 4.2 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(C(F)(F)F)ccc2Cl)CC1 10.1021/jm030944+
10342554 111559 0 None -33 3 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 428 7 0 6 3.8 CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3CCCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00436-5
CHEMBL310890 111559 0 None -33 3 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 428 7 0 6 3.8 CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3CCCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00436-5
46934787 23458 0 None -13 4 Human 7.4 pKi = 7.4 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 465 7 0 7 2.2 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242724 23458 0 None -13 4 Human 7.4 pKi = 7.4 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 465 7 0 7 2.2 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
118716709 121781 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 5 0 6 3.1 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)C4CCCCC4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342862 121781 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 5 0 6 3.1 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)C4CCCCC4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
10556164 128474 0 None -977 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 572 8 3 6 3.1 CC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1cc(F)c(F)c(F)c1 10.1021/jm990202+
CHEMBL358795 128474 0 None -977 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 572 8 3 6 3.1 CC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1cc(F)c(F)c(F)c1 10.1021/jm990202+
CHEMBL4520788 220754 10 None -18 25 Human 6.4 pKi = 6.4 Binding
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a ADRA1DSelectivity interaction (GPCR panel (PDSP screen)) EUB0000743a ADRA1D
ChEMBL None None None CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 10.6019/CHEMBL5212743
44390749 70684 0 None -213 6 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 607 11 3 6 5.3 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1016/s0960-894x(99)00484-9
CHEMBL180561 70684 0 None -213 6 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 607 11 3 6 5.3 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1016/s0960-894x(99)00484-9
10603727 44464 0 None -331 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 606 10 3 8 3.4 CCC1=C(C(=O)NC)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
CHEMBL145752 44464 0 None -331 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 606 10 3 8 3.4 CCC1=C(C(=O)NC)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
9894818 105701 0 None -138 7 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL279436 105701 0 None -138 7 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
44390749 70684 0 None -213 6 Human 6.4 pKi = 6.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 607 11 3 6 5.3 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm960697s
CHEMBL180561 70684 0 None -213 6 Human 6.4 pKi = 6.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 607 11 3 6 5.3 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm960697s
46934643 23449 0 None -6 4 Human 8.4 pKi = 8.4 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 479 7 0 6 3.5 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3CCCCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242632 23449 0 None -6 4 Human 8.4 pKi = 8.4 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 479 7 0 6 3.5 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3CCCCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
90645600 119210 0 None 1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 640 12 2 9 4.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCN(C)Cc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298018 119210 0 None 1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 640 12 2 9 4.6 COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCN(C)Cc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
3033538 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
7155 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
781 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
CHEMBL1201216 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
DB00298 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 nan
11857862 148832 0 None 2 4 Human 8.4 pKi = 8.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 538 10 1 6 4.8 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL387833 148832 0 None 2 4 Human 8.4 pKi = 8.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 538 10 1 6 4.8 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
10624665 107108 0 None -1 3 Rat 8.4 pKi = 8.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 482 4 1 7 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5c(Cl)ccnc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL289437 107108 0 None -1 3 Rat 8.4 pKi = 8.4 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 482 4 1 7 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5c(Cl)ccnc54)c3=O)C[C@@H]21 10.1021/jm990567u
10974101 123731 0 None -26 5 Human 8.4 pKi = 8.4 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 609 10 1 9 4.2 Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C)CC3)cccc2c1=O 10.1021/jm030825u
CHEMBL338608 123731 0 None -26 5 Human 8.4 pKi = 8.4 Binding
Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)Inhibition of [3H]-prazosin binding to cloned human Alpha-1D adrenergic receptor in CHO cells (chinese hamster ovary cells)
ChEMBL 609 10 1 9 4.2 Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C)CC3)cccc2c1=O 10.1021/jm030825u
49832187 174362 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 357 7 1 4 3.1 CS(=O)(=O)c1ccccc1CNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
CHEMBL4213993 174362 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 357 7 1 4 3.1 CS(=O)(=O)c1ccccc1CNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
CHEMBL4300720 174362 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 357 7 1 4 3.1 CS(=O)(=O)c1ccccc1CNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
12840734 107706 3 None 8 5 Rat 8.4 pKi = 8.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 355 4 0 4 2.5 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2)CC1 10.1021/jm030944+
CHEMBL293968 107706 3 None 8 5 Rat 8.4 pKi = 8.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 355 4 0 4 2.5 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2)CC1 10.1021/jm030944+
11123606 212214 0 None -2 4 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 475 9 1 8 3.3 COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL80260 212214 0 None -2 4 Human 8.4 pKi = 8.4 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 475 9 1 8 3.3 COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 10.1021/jm0009336
155544514 183134 0 None -1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 10 1 5 4.2 COc1ccccc1OCCNC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4526865 183134 0 None -1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 10 1 5 4.2 COc1ccccc1OCCNC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4595671 183134 0 None -1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 10 1 5 4.2 COc1ccccc1OCCNC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
10743111 205474 0 None 1 3 Rat 8.4 pKi = 8.4 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 473 5 1 6 4.1 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(-c5ccccc5)sc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL58105 205474 0 None 1 3 Rat 8.4 pKi = 8.4 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 473 5 1 6 4.1 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(-c5ccccc5)sc4c3=O)C[C@@H]21 10.1021/jm000541z
10091187 85599 1 None -21 6 Human 8.4 pKi = 8.4 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 380 5 0 4 4.6 COc1cccc(C2CCC(N3CCN(c4ccccc4OC)CC3)CC2)c1 10.1021/jm010866v
CHEMBL2112779 85599 1 None -21 6 Human 8.4 pKi = 8.4 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 380 5 0 4 4.6 COc1cccc(C2CCC(N3CCN(c4ccccc4OC)CC3)CC2)c1 10.1021/jm010866v
3251 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2010.05.023
5684 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2010.05.023
80 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2010.05.023
CHEMBL31354 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2010.05.023
3251 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2019.05.024
5684 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2019.05.024
80 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2019.05.024
CHEMBL31354 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2019.05.024
3251 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2019.02.056
5684 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2019.02.056
80 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2019.02.056
CHEMBL31354 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2019.02.056
134150497 158871 0 None 1 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 324 6 0 3 3.8 CC(C)Oc1ccccc1N1CCN(CCc2ccccc2)CC1 10.1016/j.ejmech.2016.06.052
CHEMBL3967641 158871 0 None 1 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 minsDisplacement of [3H]prazosin from human alpha1D-adrenoceptor expressed in CHO cell membranes measured after 30 mins
ChEMBL 324 6 0 3 3.8 CC(C)Oc1ccccc1N1CCN(CCc2ccccc2)CC1 10.1016/j.ejmech.2016.06.052
3251 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1021/jm200421e
5684 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1021/jm200421e
80 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1021/jm200421e
CHEMBL31354 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1021/jm200421e
11109088 210959 0 None 3 6 Human 8.3 pKi = 8.3 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70751 210959 0 None 3 6 Human 8.3 pKi = 8.3 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1 10.1021/jm000542r
118716700 121771 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 437 6 0 6 3.2 COc1ccccc1N1CCN(CC2COC3(CCN(Cc4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342853 121771 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 437 6 0 6 3.2 COc1ccccc1N1CCN(CC2COC3(CCN(Cc4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
44288392 107145 0 None 1 3 Rat 8.3 pKi = 8.3 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 475 6 1 6 4.4 COc1cccc2c1CCC1CN(CCCCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
CHEMBL289758 107145 0 None 1 3 Rat 8.3 pKi = 8.3 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 475 6 1 6 4.4 COc1cccc2c1CCC1CN(CCCCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
46934945 23470 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 533 7 0 7 3.8 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CC4(CCCC4)CC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242912 23470 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 533 7 0 7 3.8 COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CC4(CCCC4)CC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
76323010 113025 0 None -5 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL2261606 113025 0 None -5 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL3138929 113025 0 None -5 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
16721032 98963 0 None -5 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL242507 98963 0 None -5 6 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 451 4 1 8 3.4 COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
44431554 95118 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234874 95118 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 475 7 1 5 4.0 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
57929612 146856 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 373 4 2 5 1.8 CS(=O)(=O)c1cc(Cl)cc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3800506 146856 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 373 4 2 5 1.8 CS(=O)(=O)c1cc(Cl)cc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
16041630 104323 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL270589 104323 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
11049209 214184 0 None -9 9 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 486 6 1 5 4.4 Cn1ccc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
CHEMBL93923 214184 0 None -9 9 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 486 6 1 5 4.4 Cn1ccc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
2389 10104 118 None -24 66 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
5073 10104 118 None -24 66 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
96 10104 118 None -24 66 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
CHEMBL85 10104 118 None -24 66 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
DB00734 10104 118 None -24 66 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 nan
289 7030 12 None -3 14 Human 7.4 pKi = 7.4 Binding
Binding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assayBinding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assay
ChEMBL 301 8 0 2 4.9 CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C 10.1021/jm100697g
9948320 7030 12 None -3 14 Human 7.4 pKi = 7.4 Binding
Binding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assayBinding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assay
ChEMBL 301 8 0 2 4.9 CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C 10.1021/jm100697g
CHEMBL1242950 7030 12 None -3 14 Human 7.4 pKi = 7.4 Binding
Binding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assayBinding affinity to human adrenergic Alpha-1D receptor by radioligand displacement assay
ChEMBL 301 8 0 2 4.9 CCCCC1CCN(CC1)CCCC(=O)c1ccccc1C 10.1021/jm100697g
11857638 148933 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 516 9 1 6 5.0 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
11857638 148933 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 516 9 1 6 5.0 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL388361 148933 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 516 9 1 6 5.0 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL388361 148933 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 516 9 1 6 5.0 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
10674840 210495 0 None -50 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 585 10 2 8 3.3 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL67648 210495 0 None -50 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 585 10 2 8 3.3 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
10507357 210715 0 None -58 2 Human 6.4 pKi = 6.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 574 10 1 7 4.0 COC(CNC(=O)c1ccc2c(c1)C(=O)N(c1cccc(F)c1)C2=O)CN1CCN(c2ccccc2OC(C)C)CC1 10.1021/jm9905918
CHEMBL69245 210715 0 None -58 2 Human 6.4 pKi = 6.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 574 10 1 7 4.0 COC(CNC(=O)c1ccc2c(c1)C(=O)N(c1cccc(F)c1)C2=O)CN1CCN(c2ccccc2OC(C)C)CC1 10.1021/jm9905918
19085866 112194 0 None -338 3 Human 7.4 pKi = 7.4 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 455 6 0 7 2.9 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL311890 112194 0 None -338 3 Human 7.4 pKi = 7.4 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 455 6 0 7 2.9 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
10627003 211119 0 None -53 3 Human 7.4 pKi = 7.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 576 9 2 7 3.8 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(Cl)c2)C3=O)CC1 10.1021/jm9905918
CHEMBL71580 211119 0 None -53 3 Human 7.4 pKi = 7.4 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 576 9 2 7 3.8 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(Cl)c2)C3=O)CC1 10.1021/jm9905918
1353 8692 93 None -10 85 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
3559 8692 93 None -10 85 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
86 8692 93 None -10 85 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
CHEMBL54 8692 93 None -10 85 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
DB00502 8692 93 None -10 85 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl nan
135 9310 43 None -10 56 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
1796 9310 43 None -10 56 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
4184 9310 43 None -10 56 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
CHEMBL6437 9310 43 None -10 56 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
DB06148 9310 43 None -10 56 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 nan
3168 16034 92 None -29 22 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 nan
CHEMBL1108 16034 92 None -29 22 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 nan
3000341 208310 13 None 11 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 368 4 1 4 3.8 CC[C@@H]1CN2CCc3c([nH]c4ccccc34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC 10.1021/acs.jmedchem.9b01465
CHEMBL60533 208310 13 None 11 5 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 368 4 1 4 3.8 CC[C@@H]1CN2CCc3c([nH]c4ccccc34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC 10.1021/acs.jmedchem.9b01465
10744391 214142 0 None -37 3 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 514 7 1 3 4.8 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H](c2ccc(F)c(F)c2)N(C)C(=O)N1C 10.1021/jm990612y
CHEMBL93693 214142 0 None -37 3 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 514 7 1 3 4.8 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H](c2ccc(F)c(F)c2)N(C)C(=O)N1C 10.1021/jm990612y
44435200 156454 0 None -2 4 Human 5.4 pKi = 5.4 Binding
Antagonist activity at adrenergic alpha 1D receptor (unknown origin) by PDSP assayAntagonist activity at adrenergic alpha 1D receptor (unknown origin) by PDSP assay
ChEMBL 345 4 0 2 5.8 O=C(CCCc1ccccc1)N1c2ccccc2Sc2ccccc21 10.1016/j.bmcl.2013.04.082
CHEMBL394755 156454 0 None -2 4 Human 5.4 pKi = 5.4 Binding
Antagonist activity at adrenergic alpha 1D receptor (unknown origin) by PDSP assayAntagonist activity at adrenergic alpha 1D receptor (unknown origin) by PDSP assay
ChEMBL 345 4 0 2 5.8 O=C(CCCc1ccccc1)N1c2ccccc2Sc2ccccc21 10.1016/j.bmcl.2013.04.082
44301573 209576 0 None -416 3 Human 5.4 pKi = 5.4 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 535 7 1 5 4.6 Cc1ccc(C2(c3ccc(C)cc3)CC(=O)N(CC(O)CN3CCC(C#N)(c4ccccc4C)CC3)C2=O)cc1 10.1016/s0960-894x(01)00320-1
CHEMBL62249 209576 0 None -416 3 Human 5.4 pKi = 5.4 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 535 7 1 5 4.6 Cc1ccc(C2(c3ccc(C)cc3)CC(=O)N(CC(O)CN3CCC(C#N)(c4ccccc4C)CC3)C2=O)cc1 10.1016/s0960-894x(01)00320-1
44318000 212176 0 None -51 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 480 7 0 7 4.0 CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3C(=O)CC4(CCCC4)CC3=O)co2)CC1 10.1016/s0960-894x(02)00436-5
CHEMBL80036 212176 0 None -51 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 480 7 0 7 4.0 CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3C(=O)CC4(CCCC4)CC3=O)co2)CC1 10.1016/s0960-894x(02)00436-5
44417706 18607 0 None -12 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 395 8 1 6 3.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1 10.1021/jm060358r
CHEMBL1182152 18607 0 None -12 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 395 8 1 6 3.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1 10.1021/jm060358r
CHEMBL215188 18607 0 None -12 7 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 395 8 1 6 3.7 COc1cccc(OC)c1OCCNC[C@H]1COc2cc3ccccc3cc2O1 10.1021/jm060358r
118716712 121784 0 None -1 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 443 4 0 6 2.1 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)C(F)(F)F)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342865 121784 0 None -1 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 443 4 0 6 2.1 COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)C(F)(F)F)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
44311789 211514 0 None -3 5 Human 4.4 pKi = 4.4 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 345 1 2 5 3.1 Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL74342 211514 0 None -3 5 Human 4.4 pKi = 4.4 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 345 1 2 5 3.1 Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
44328920 115418 0 None -36 6 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 705 14 3 7 5.9 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCC(F)(F)F)N1 10.1016/s0960-894x(99)00484-9
CHEMBL320736 115418 0 None -36 6 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 705 14 3 7 5.9 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCC(F)(F)F)N1 10.1016/s0960-894x(99)00484-9
71061709 156306 0 None -28 12 Mouse 5.4 pKi = 5.4 Binding
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 372 6 0 4 3.5 Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 nan
CHEMBL3946540 156306 0 None -28 12 Mouse 5.4 pKi = 5.4 Binding
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 372 6 0 4 3.5 Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 nan
118716701 121772 0 None 2 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 380 4 0 6 1.5 COc1ccccc1N1CCN(CC2COC3(CC[S+]([O-])CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342854 121772 0 None 2 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 380 4 0 6 1.5 COc1ccccc1N1CCN(CC2COC3(CC[S+]([O-])CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
59151668 146852 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 262 3 2 4 1.2 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccccn1 10.1021/acs.jmedchem.5b01528
CHEMBL3800485 146852 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 262 3 2 4 1.2 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccccn1 10.1021/acs.jmedchem.5b01528
44295046 108710 0 None -380 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 577 8 2 9 2.8 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL301077 108710 0 None -380 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 577 8 2 9 2.8 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(99)00653-8
44295218 195881 0 None -27 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 582 8 2 7 3.5 COC(=O)C1(c2ccccc2)CCN(CCCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL51019 195881 0 None -27 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 582 8 2 7 3.5 COC(=O)C1(c2ccccc2)CCN(CCCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
9916549 128342 0 None -1023 4 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 592 10 3 8 3.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
CHEMBL358595 128342 0 None -1023 4 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 592 10 3 8 3.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
101333429 123854 0 None -1071 6 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1 10.1021/jm00019a001
CHEMBL3392247 123854 0 None -1071 6 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1cccc([N+](=O)[O-])c1 10.1021/jm00019a001
11312410 15674 0 None -9 3 Rat 5.4 pKi = 5.4 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 293 3 2 4 1.5 CS(=O)(=O)Nc1cccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
CHEMBL109755 15674 0 None -9 3 Rat 5.4 pKi = 5.4 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 293 3 2 4 1.5 CS(=O)(=O)Nc1cccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
11312410 15674 0 None -9 3 Rat 5.4 pKi = 5.4 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 293 3 2 4 1.5 CS(=O)(=O)Nc1cccc2c1CCCC2C1=NCCN1 10.1021/jm030551a
CHEMBL109755 15674 0 None -9 3 Rat 5.4 pKi = 5.4 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 293 3 2 4 1.5 CS(=O)(=O)Nc1cccc2c1CCCC2C1=NCCN1 10.1021/jm030551a
11201573 204436 0 None 3 2 Rat 6.4 pKi = 6.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 442 5 0 6 1.6 COc1ccccc1N1CCN(CCN2C(=O)CC3(CCN(C(C)=O)CC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL57097 204436 0 None 3 2 Rat 6.4 pKi = 6.4 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 442 5 0 6 1.6 COc1ccccc1N1CCN(CCN2C(=O)CC3(CCN(C(C)=O)CC3)CC2=O)CC1 10.1021/jm030944+
53328312 70160 0 None 1 3 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 425 6 0 4 3.8 O=C1CC(c2ccccc2)CC(=O)N1CCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796031 70160 0 None 1 3 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 425 6 0 4 3.8 O=C1CC(c2ccccc2)CC(=O)N1CCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
25130879 180016 0 None -10 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@@H]1COC[C@H](c2ccccc2)O1 10.1021/jm800461k
CHEMBL452437 180016 0 None -10 4 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@@H]1COC[C@H](c2ccccc2)O1 10.1021/jm800461k
9959689 108590 0 None -281 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 568 7 2 7 3.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL300222 108590 0 None -281 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 568 7 2 7 3.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
136806212 214511 0 None -114 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 636 13 4 7 4.6 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCN)N1 10.1016/s0960-894x(99)00484-9
44328639 214511 0 None -114 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 636 13 4 7 4.6 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL95736 214511 0 None -114 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 636 13 4 7 4.6 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCN)N1 10.1016/s0960-894x(99)00484-9
10626982 118272 0 None -7 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 575 9 2 6 5.9 CC1=C(C#N)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL327775 118272 0 None -7 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 575 9 2 6 5.9 CC1=C(C#N)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
44361064 38389 0 None -16 6 Human 6.4 pKi = 6.4 Binding
Compound was tested for binding affinity against human hippocampus Alpha-1D adrenergic receptor using radioligand ([3H]prazosin) binding assayCompound was tested for binding affinity against human hippocampus Alpha-1D adrenergic receptor using radioligand ([3H]prazosin) binding assay
ChEMBL 338 7 2 4 4.5 N=CCC(O)CC1CCN(c2ccccc2Oc2ccccc2)CC1 10.1021/jm960510x
CHEMBL140450 38389 0 None -16 6 Human 6.4 pKi = 6.4 Binding
Compound was tested for binding affinity against human hippocampus Alpha-1D adrenergic receptor using radioligand ([3H]prazosin) binding assayCompound was tested for binding affinity against human hippocampus Alpha-1D adrenergic receptor using radioligand ([3H]prazosin) binding assay
ChEMBL 338 7 2 4 4.5 N=CCC(O)CC1CCN(c2ccccc2Oc2ccccc2)CC1 10.1021/jm960510x
44420419 90206 0 None -2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 485 4 0 7 3.3 Cn1c(=O)n(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)c(=O)c2c1c1ccccc1n2C 10.1016/j.bmcl.2006.09.034
CHEMBL219719 90206 0 None -2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 485 4 0 7 3.3 Cn1c(=O)n(CCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)c(=O)c2c1c1ccccc1n2C 10.1016/j.bmcl.2006.09.034
3198 212292 76 None -30 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 212292 76 None -30 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 212292 76 None -30 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44431615 94813 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 521 8 1 5 4.7 O=S(=O)(N[C@H]1CC[C@@H](N2CCN(c3ccccc3OCC3CC3)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.008
CHEMBL234476 94813 0 None -1 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 521 8 1 5 4.7 O=S(=O)(N[C@H]1CC[C@@H](N2CCN(c3ccccc3OCC3CC3)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.008
11857793 92433 0 None -9 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 548 7 1 4 5.9 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.098
CHEMBL228494 92433 0 None -9 4 Human 7.4 pKi = 7.4 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 548 7 1 4 5.9 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cc(Cl)ccc1F 10.1016/j.bmcl.2007.04.098
44316072 211795 0 None -4 3 Human 7.4 pKi = 7.4 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 425 7 0 6 3.0 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)nn2C)CC1 10.1016/s0960-894x(00)00472-8
CHEMBL76867 211795 0 None -4 3 Human 7.4 pKi = 7.4 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 425 7 0 6 3.0 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)nn2C)CC1 10.1016/s0960-894x(00)00472-8
10031709 44085 0 None -4365 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 613 10 0 5 8.1 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccc(C)cc3)(c3ccccc3C)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL145411 44085 0 None -4365 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 613 10 0 5 8.1 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccc(C)cc3)(c3ccccc3C)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10371061 43475 0 None -1905 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
CHEMBL144925 43475 0 None -1905 3 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 583 9 3 6 3.5 CCC1=C(C(N)=O)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
10793665 113729 0 None -251 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 597 9 2 5 7.2 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)cc1 10.1021/jm980077m
CHEMBL314960 113729 0 None -251 6 Human 6.4 pKi = 6.4 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 597 9 2 5 7.2 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)cc1 10.1021/jm980077m
44275255 105380 0 None -354 3 Human 6.4 pKi = 6.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 636 12 2 7 7.2 CCC1=NC(CC)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)/C1=C(\O)OC 10.1021/jm960697s
CHEMBL276932 105380 0 None -354 3 Human 6.4 pKi = 6.4 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 636 12 2 7 7.2 CCC1=NC(CC)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)/C1=C(\O)OC 10.1021/jm960697s
10221830 16193 0 None -1 3 Rat 6.4 pKi = 6.4 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 387 5 2 3 4.7 CCS(=O)(=O)Nc1cc(C2CCCCC2)cc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL111685 16193 0 None -1 3 Rat 6.4 pKi = 6.4 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 387 5 2 3 4.7 CCS(=O)(=O)Nc1cc(C2CCCCC2)cc2c1CCCC2c1c[nH]cn1 10.1021/jm030551a
136680385 214429 0 None -147 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 694 16 4 8 4.9 CCNC(=O)C1=C(COCCN)NC(CC)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
44328824 214429 0 None -147 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 694 16 4 8 4.9 CCNC(=O)C1=C(COCCN)NC(CC)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
CHEMBL95253 214429 0 None -147 3 Human 6.4 pKi = 6.4 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 694 16 4 8 4.9 CCNC(=O)C1=C(COCCN)NC(CC)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
135398745 9688 112 None -24 65 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
47 9688 112 None -24 65 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
CHEMBL715 9688 112 None -24 65 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
DB00334 9688 112 None -24 65 Human 7.4 pKi = 7.4 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C nan
2142 9870 58 None -12 37 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm020938y
4920903 9870 58 None -12 37 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm020938y
502 9870 58 None -12 37 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm020938y
5775 9870 58 None -12 37 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm020938y
CHEMBL597 9870 58 None -12 37 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm020938y
DB00692 9870 58 None -12 37 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/jm020938y
53328311 70159 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 421 7 0 5 3.1 COc1ccccc1N1CCN(CCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796030 70159 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 421 7 0 5 3.1 COc1ccccc1N1CCN(CCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
44267817 170029 0 None -53 3 Human 5.4 pKi = 5.4 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 420 8 1 5 1.9 CC(C)Oc1cc(F)ccc1N1CCN(CCNC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL418531 170029 0 None -53 3 Human 5.4 pKi = 5.4 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 420 8 1 5 1.9 CC(C)Oc1cc(F)ccc1N1CCN(CCNC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
53315878 99730 66 None -100 2 Human 5.4 pKi = 5.4 Binding
Binding affinity to adrenergic alpha1D receptor (unknown origin) by radioligand binding assayBinding affinity to adrenergic alpha1D receptor (unknown origin) by radioligand binding assay
ChEMBL 546 10 1 8 5.0 COc1cc2c(NC3CCN(C(C)C)CC3)nc(N3CCC(F)(F)CC3)nc2cc1OCCCN1CCCC1 10.1021/jm401480r
CHEMBL2441082 99730 66 None -100 2 Human 5.4 pKi = 5.4 Binding
Binding affinity to adrenergic alpha1D receptor (unknown origin) by radioligand binding assayBinding affinity to adrenergic alpha1D receptor (unknown origin) by radioligand binding assay
ChEMBL 546 10 1 8 5.0 COc1cc2c(NC3CCN(C(C)C)CC3)nc(N3CCC(F)(F)CC3)nc2cc1OCCCN1CCCC1 10.1021/jm401480r
53315878 99730 66 None -100 2 Human 5.4 pKi = 5.4 Binding
Selectivity interaction (Enzyme panel (GPCRS, ion channels, and transporters)) EUB0000194b ADRA1DSelectivity interaction (Enzyme panel (GPCRS, ion channels, and transporters)) EUB0000194b ADRA1D
ChEMBL 546 10 1 8 5.0 COc1cc2c(NC3CCN(C(C)C)CC3)nc(N3CCC(F)(F)CC3)nc2cc1OCCCN1CCCC1 10.6019/CHEMBL5212743
CHEMBL2441082 99730 66 None -100 2 Human 5.4 pKi = 5.4 Binding
Selectivity interaction (Enzyme panel (GPCRS, ion channels, and transporters)) EUB0000194b ADRA1DSelectivity interaction (Enzyme panel (GPCRS, ion channels, and transporters)) EUB0000194b ADRA1D
ChEMBL 546 10 1 8 5.0 COc1cc2c(NC3CCN(C(C)C)CC3)nc(N3CCC(F)(F)CC3)nc2cc1OCCCN1CCCC1 10.6019/CHEMBL5212743
44329026 215204 0 None -89 6 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 679 16 3 7 6.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCOC)N1 10.1016/s0960-894x(99)00484-9
CHEMBL99864 215204 0 None -89 6 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 679 16 3 7 6.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CCCCOC)N1 10.1016/s0960-894x(99)00484-9
10507651 213286 0 None -51 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 591 9 2 6 5.8 CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
CHEMBL88388 213286 0 None -51 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 591 9 2 6 5.8 CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2 10.1021/jm980077m
42 8844 57 None -8 18 Human 7.3 pKi = 7.3 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 401 6 0 7 1.2 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/s0960-894x(98)00451-x
56971 8844 57 None -8 18 Human 7.3 pKi = 7.3 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 401 6 0 7 1.2 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/s0960-894x(98)00451-x
CHEMBL8412 8844 57 None -8 18 Human 7.3 pKi = 7.3 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 401 6 0 7 1.2 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 10.1016/s0960-894x(98)00451-x
44431617 95117 0 None -9 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 458 7 1 6 3.3 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234854 95117 0 None -9 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 458 7 1 6 3.3 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
16041263 102222 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL257098 102222 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 10.1016/j.bmcl.2007.11.068
11154311 107500 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 418 5 0 6 2.6 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc([N+](=O)[O-])ccc2F)CC1 10.1021/jm030944+
CHEMBL292637 107500 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 418 5 0 6 2.6 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc([N+](=O)[O-])ccc2F)CC1 10.1021/jm030944+
127035062 143229 0 None -16 19 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D receptor after 90 mins by scintillation counting methodDisplacement of [3H]Prazosin from human recombinant alpha 1D receptor after 90 mins by scintillation counting method
ChEMBL 447 12 0 5 5.2 COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC 10.1039/C4MD00418C
CHEMBL3735756 143229 0 None -16 19 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D receptor after 90 mins by scintillation counting methodDisplacement of [3H]Prazosin from human recombinant alpha 1D receptor after 90 mins by scintillation counting method
ChEMBL 447 12 0 5 5.2 COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC 10.1039/C4MD00418C
9895326 213806 0 None -436 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 621 12 3 6 5.7 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CC)N1 10.1021/jm980077m
CHEMBL91550 213806 0 None -436 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 621 12 3 6 5.7 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CC)N1 10.1021/jm980077m
11857710 92395 0 None -10 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 518 8 1 5 5.4 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1 10.1016/j.bmcl.2007.04.098
CHEMBL228279 92395 0 None -10 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 518 8 1 5 5.4 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1 10.1016/j.bmcl.2007.04.098
18738384 171156 0 None -25 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 441 7 0 5 4.8 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL421297 171156 0 None -25 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 441 7 0 5 4.8 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00347-5
44288469 168469 0 None -1 3 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1ccc2c(c1)CCC1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
CHEMBL41332 168469 0 None -1 3 Rat 7.3 pKi = 7.3 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1ccc2c(c1)CCC1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
2337 10030 77 None -2 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
50 10030 77 None -2 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
5002 10030 77 None -2 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
CHEMBL716 10030 77 None -2 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
DB01224 10030 77 None -2 62 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 nan
2351 10059 64 None -8 21 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 10059 64 None -8 21 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 10059 64 None -8 21 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 10059 64 None -8 21 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 10059 64 None -8 21 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
11034737 211307 0 None -2 6 Human 6.3 pKi = 6.3 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 289 4 2 4 2.8 CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72724 211307 0 None -2 6 Human 6.3 pKi = 6.3 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 289 4 2 4 2.8 CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 10.1021/jm000542r
101876962 121916 0 None -66 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 342 5 2 4 4.9 Cc1cccc2c(NCCNc3ccnc4c(C)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
CHEMBL3343979 121916 0 None -66 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 342 5 2 4 4.9 Cc1cccc2c(NCCNc3ccnc4c(C)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
118717458 121918 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 412 10 2 4 6.9 Cc1ccc2nccc(NCCCCCCCNc3ccnc4ccc(C)cc34)c2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343980 121918 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 412 10 2 4 6.9 Cc1ccc2nccc(NCCCCCCCNc3ccnc4ccc(C)cc34)c2c1 10.1016/j.bmc.2014.09.017
9880162 16074 0 None 1 3 Rat 6.3 pKi = 6.3 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 321 4 2 4 2.3 COc1ccc2c(c1NS(C)(=O)=O)CCCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL110976 16074 0 None 1 3 Rat 6.3 pKi = 6.3 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 321 4 2 4 2.3 COc1ccc2c(c1NS(C)(=O)=O)CCCC2c1c[nH]cn1 10.1021/jm030551a
10221005 211101 0 None -6 4 Human 5.3 pKi = 5.3 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 267 4 2 5 0.8 Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1021/jm000542r
CHEMBL71479 211101 0 None -6 4 Human 5.3 pKi = 5.3 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 267 4 2 5 0.8 Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1021/jm000542r
101876962 121916 0 None -66 4 Human 6.3 pKi = 6.3 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 342 5 2 4 4.9 Cc1cccc2c(NCCNc3ccnc4c(C)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
CHEMBL3343979 121916 0 None -66 4 Human 6.3 pKi = 6.3 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 342 5 2 4 4.9 Cc1cccc2c(NCCNc3ccnc4c(C)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
118717458 121918 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 412 10 2 4 6.9 Cc1ccc2nccc(NCCCCCCCNc3ccnc4ccc(C)cc34)c2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343980 121918 0 None -3 4 Human 6.3 pKi = 6.3 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 412 10 2 4 6.9 Cc1ccc2nccc(NCCCCCCCNc3ccnc4ccc(C)cc34)c2c1 10.1016/j.bmc.2014.09.017
44431614 94812 0 None -2 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 533 9 1 6 4.5 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OCC3CC3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234474 94812 0 None -2 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 533 9 1 6 4.5 COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OCC3CC3)CC2)CC1 10.1016/j.bmcl.2007.04.008
145950240 169480 0 None -2 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 465 5 2 9 2.2 COc1cc2nc(N3CCC[C@H](NC(=O)[C@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
CHEMBL4170675 169480 0 None -2 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins
ChEMBL 465 5 2 9 2.2 COc1cc2nc(N3CCC[C@H](NC(=O)[C@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC 10.1016/j.ejmech.2017.05.003
10626772 43010 0 None -1202 3 Human 6.3 pKi = 6.3 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 564 11 0 7 5.5 COCC1=NC(C)=C(C(=O)OC)C(c2ccc(F)c(F)c2)N1CCCCCN1CCC(C#N)(c2ccccc2)CC1 10.1021/jm9902032
CHEMBL144534 43010 0 None -1202 3 Human 6.3 pKi = 6.3 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 564 11 0 7 5.5 COCC1=NC(C)=C(C(=O)OC)C(c2ccc(F)c(F)c2)N1CCCCCN1CCC(C#N)(c2ccccc2)CC1 10.1021/jm9902032
10029146 212470 0 None -933 3 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 504 8 0 6 3.9 CCOC(=O)[C@@H]1CN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC[C@@H]1c1ccccc1 10.1016/s0960-894x(98)00451-x
CHEMBL82267 212470 0 None -933 3 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assayBinding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
ChEMBL 504 8 0 6 3.9 CCOC(=O)[C@@H]1CN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC[C@@H]1c1ccccc1 10.1016/s0960-894x(98)00451-x
10578735 127898 0 None -33 3 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 557 8 2 7 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(OC)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL357439 127898 0 None -33 3 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 557 8 2 7 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(OC)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
10840177 44890 0 None -954 3 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 540 7 2 5 4.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL146109 44890 0 None -954 3 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 540 7 2 5 4.6 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
44301681 209473 0 None -831 3 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 481 8 2 4 4.6 Cc1ccc(C(O)(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(01)00320-1
CHEMBL61643 209473 0 None -831 3 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 481 8 2 4 4.6 Cc1ccc(C(O)(C(=O)NCCCN2CCC(C#N)(c3ccccc3)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(01)00320-1
10841190 113819 0 None -69 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 10 2 6 6.5 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC)cc1 10.1021/jm980077m
CHEMBL315538 113819 0 None -69 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 10 2 6 6.5 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC)cc1 10.1021/jm980077m
118717455 121913 0 None -25 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 342 5 2 4 4.9 Cc1ccc2nccc(NCCNc3ccnc4ccc(C)cc34)c2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343976 121913 0 None -25 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 342 5 2 4 4.9 Cc1ccc2nccc(NCCNc3ccnc4ccc(C)cc34)c2c1 10.1016/j.bmc.2014.09.017
118717460 121920 0 None -9 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 412 10 2 4 6.9 Cc1ccc2c(NCCCCCCCNc3ccnc4cc(C)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343982 121920 0 None -9 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 412 10 2 4 6.9 Cc1ccc2c(NCCCCCCCNc3ccnc4cc(C)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
11857861 92451 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 520 10 1 6 4.5 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
11857861 92451 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 520 10 1 6 4.5 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL228606 92451 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 520 10 1 6 4.5 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL228606 92451 0 None 1 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 520 10 1 6 4.5 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
9883506 77339 0 None -3 6 Human 7.3 pKi = 7.3 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 282 3 3 5 2.3 Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1 10.1016/j.bmcl.2005.07.083
CHEMBL194849 77339 0 None -3 6 Human 7.3 pKi = 7.3 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
ChEMBL 282 3 3 5 2.3 Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1 10.1016/j.bmcl.2005.07.083
118717455 121913 0 None -25 4 Human 6.3 pKi = 6.3 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 342 5 2 4 4.9 Cc1ccc2nccc(NCCNc3ccnc4ccc(C)cc34)c2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343976 121913 0 None -25 4 Human 6.3 pKi = 6.3 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 342 5 2 4 4.9 Cc1ccc2nccc(NCCNc3ccnc4ccc(C)cc34)c2c1 10.1016/j.bmc.2014.09.017
118717460 121920 0 None -9 4 Human 6.3 pKi = 6.3 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 412 10 2 4 6.9 Cc1ccc2c(NCCCCCCCNc3ccnc4cc(C)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
CHEMBL3343982 121920 0 None -9 4 Human 6.3 pKi = 6.3 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 412 10 2 4 6.9 Cc1ccc2c(NCCCCCCCNc3ccnc4cc(C)ccc34)ccnc2c1 10.1016/j.bmc.2014.09.017
10529370 213718 0 None -1122 3 Human 6.3 pKi = 6.3 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 499 9 3 5 3.0 COCC1=C(C(=O)NCCCN2CCC(c3ccccn3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
CHEMBL91125 213718 0 None -1122 3 Human 6.3 pKi = 6.3 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 499 9 3 5 3.0 COCC1=C(C(=O)NCCCN2CCC(c3ccccn3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 10.1021/jm990612y
46915370 61741 0 None 1 6 Human 6.3 pKi = 6.3 Binding
Binding affinity to adrenergic Alpha-1D receptorBinding affinity to adrenergic Alpha-1D receptor
ChEMBL 195 0 3 5 -1.6 Cn1c(=O)[nH]c2c([nH]c(=O)n2C)c1=N 10.1021/jm100490m
CHEMBL1241328 61741 0 None 1 6 Human 6.3 pKi = 6.3 Binding
Binding affinity to adrenergic Alpha-1D receptorBinding affinity to adrenergic Alpha-1D receptor
ChEMBL 195 0 3 5 -1.6 Cn1c(=O)[nH]c2c([nH]c(=O)n2C)c1=N 10.1021/jm100490m
CHEMBL1615596 61741 0 None 1 6 Human 6.3 pKi = 6.3 Binding
Binding affinity to adrenergic Alpha-1D receptorBinding affinity to adrenergic Alpha-1D receptor
ChEMBL 195 0 3 5 -1.6 Cn1c(=O)[nH]c2c([nH]c(=O)n2C)c1=N 10.1021/jm100490m
102 10899 48 None -363 49 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
3659 10899 48 None -363 49 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
8969 10899 48 None -363 49 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
CHEMBL15245 10899 48 None -363 49 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
DB01392 10899 48 None -363 49 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 nan
44431574 94577 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 505 8 1 6 4.0 COc1ccc(F)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233814 94577 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 505 8 1 6 4.0 COc1ccc(F)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
3251 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2011.06.023
5684 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2011.06.023
80 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2011.06.023
CHEMBL31354 10844 58 None -15 12 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 422 7 0 5 3.8 COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1 10.1016/j.ejmech.2011.06.023
11097789 109775 1 None 3 6 Human 8.3 pKi = 8.3 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 239 4 2 4 2.0 CSc1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL306792 109775 1 None 3 6 Human 8.3 pKi = 8.3 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 239 4 2 4 2.0 CSc1cc(F)ccc1NCC1=NCCN1 10.1021/jm000542r
90645602 119212 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 553 7 1 8 5.0 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)c5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298020 119212 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 553 7 1 8 5.0 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)c5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
155562125 183122 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 8 1 4 4.4 c1ccc(OCCNCC2CCOC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4582160 183122 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 8 1 4 4.4 c1ccc(OCCNCC2CCOC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4595563 183122 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 8 1 4 4.4 c1ccc(OCCNCC2CCOC(c3ccccc3)(c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
44298611 107429 0 None -125 3 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 440 7 1 6 2.3 Cc1[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c(=O)c1C 10.1016/s0960-894x(03)00305-6
CHEMBL292189 107429 0 None -125 3 Human 8.3 pKi = 8.3 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 440 7 1 6 2.3 Cc1[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c(=O)c1C 10.1016/s0960-894x(03)00305-6
44431562 96058 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(OC)c(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)c1 10.1016/j.bmcl.2007.04.008
CHEMBL236832 96058 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(OC)c(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)c1 10.1016/j.bmcl.2007.04.008
145962368 168236 0 None -16 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 521 9 0 8 5.1 CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@H]3CCCC[C@H]32)nc2cc(OC)c(OC)cc12 10.1016/j.bmc.2018.05.023
CHEMBL4127483 168236 0 None -16 3 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 521 9 0 8 5.1 CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@H]3CCCC[C@H]32)nc2cc(OC)c(OC)cc12 10.1016/j.bmc.2018.05.023
44431545 151798 0 None 2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 457 7 1 5 3.9 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL391107 151798 0 None 2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 457 7 1 5 3.9 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
52948119 23438 0 None 2 4 Human 8.3 pKi = 8.3 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 451 7 0 6 2.7 COc1ccccc1N1CCN(C[C@@H]2CO[C@](CN3CCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242445 23438 0 None 2 4 Human 8.3 pKi = 8.3 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 451 7 0 6 2.7 COc1ccccc1N1CCN(C[C@@H]2CO[C@](CN3CCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
11235558 203954 0 None 5 2 Rat 8.3 pKi = 8.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.5 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2C(F)(F)F)CC1 10.1021/jm030944+
CHEMBL56805 203954 0 None 5 2 Rat 8.3 pKi = 8.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.5 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2C(F)(F)F)CC1 10.1021/jm030944+
10917316 212266 0 None -10 4 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 447 8 1 8 2.6 COc1ccc(Cl)cc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL80599 212266 0 None -10 4 Human 8.3 pKi = 8.3 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 447 8 1 8 2.6 COc1ccc(Cl)cc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 10.1021/jm0009336
11350756 202987 0 None 3 2 Rat 8.3 pKi = 8.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm030944+
CHEMBL56150 202987 0 None 3 2 Rat 8.3 pKi = 8.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 423 4 0 4 3.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm030944+
44299973 204231 0 None -6 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 608 7 2 8 3.4 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL56974 204231 0 None -6 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 608 7 2 8 3.4 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
10582624 209571 0 None 1 3 Rat 8.3 pKi = 8.3 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 393 4 1 7 1.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4nccnc4c3=O)C[C@@H]21 10.1021/jm000541z
CHEMBL62206 209571 0 None 1 3 Rat 8.3 pKi = 8.3 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 393 4 1 7 1.2 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4nccnc4c3=O)C[C@@H]21 10.1021/jm000541z
90645604 119214 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 652 12 2 9 5.2 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCC(=O)NCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
CHEMBL3298022 119214 0 None -1 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells
ChEMBL 652 12 2 9 5.2 COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCC(=O)NCc5ccccc5)cc43)c2=O)CC1 10.1016/j.ejmech.2014.06.057
44431617 151679 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 458 7 1 6 3.3 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL391016 151679 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 458 7 1 6 3.3 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccnc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
11857861 201559 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 520 10 1 6 4.5 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL538397 201559 0 None 1 4 Human 8.3 pKi = 8.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 520 10 1 6 4.5 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
11338314 178149 0 None 4 4 Human 8.3 pKi = 8.3 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 391 4 0 4 2.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)cc2F)CC1 10.1021/jm0491391
CHEMBL446180 178149 0 None 4 4 Human 8.3 pKi = 8.3 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 391 4 0 4 2.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)cc2F)CC1 10.1021/jm0491391
155526629 183177 0 None -11 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 10 1 5 4.4 COc1ccccc1OCCNCCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4458714 183177 0 None -11 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 10 1 5 4.4 COc1ccccc1OCCNCCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4595984 183177 0 None -11 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 10 1 5 4.4 COc1ccccc1OCCNCCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
56945164 78289 0 None -17 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 417 9 2 4 4.4 COc1ccccc1OCCNC[C@H]1CCC(c2ccccc2)(c2ccccc2)[C@@H]1O 10.1021/jm200421e
CHEMBL1946786 78289 0 None -17 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 417 9 2 4 4.4 COc1ccccc1OCCNC[C@H]1CCC(c2ccccc2)(c2ccccc2)[C@@H]1O 10.1021/jm200421e
CHEMBL1962756 78289 0 None -17 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 417 9 2 4 4.4 COc1ccccc1OCCNC[C@H]1CCC(c2ccccc2)(c2ccccc2)[C@@H]1O 10.1021/jm200421e
118716717 121789 0 None -1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 532 7 0 9 2.3 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc([N+](=O)[O-])cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342870 121789 0 None -1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 532 7 0 9 2.3 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc([N+](=O)[O-])cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
44288162 175778 0 None 2 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1ccc2c(c1)C1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC1CC2 10.1021/jm990567u
CHEMBL43921 175778 0 None 2 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1ccc2c(c1)C1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC1CC2 10.1021/jm990567u
155513941 183057 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 407 12 2 5 3.8 COc1ccccc1OCCNCC(CO)OC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.05.024
CHEMBL4439658 183057 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 407 12 2 5 3.8 COc1ccccc1OCCNCC(CO)OC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.05.024
CHEMBL4595078 183057 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 407 12 2 5 3.8 COc1ccccc1OCCNCC(CO)OC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.05.024
11857794 92434 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 562 9 1 5 5.7 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cccc(OC(F)F)c1 10.1016/j.bmcl.2007.04.098
CHEMBL228496 92434 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 562 9 1 5 5.7 O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cccc(OC(F)F)c1 10.1016/j.bmcl.2007.04.098
10917920 118223 0 None -7 10 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 487 6 1 6 3.8 Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
CHEMBL327527 118223 0 None -7 10 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 487 6 1 6 3.8 Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
49781678 24650 0 None -7 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 400 2 0 3 5.7 Cc1ccc(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)cc1 10.1021/jm100652h
CHEMBL1259079 24650 0 None -7 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 400 2 0 3 5.7 Cc1ccc(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)cc1 10.1021/jm100652h
10474042 177032 0 None -30 6 Human 8.2 pKi = 8.2 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 365 6 0 4 4.1 COc1cccc2c1CCCC2CCCN1CCN(c2ccccn2)CC1 10.1021/jm010866v
CHEMBL444590 177032 0 None -30 6 Human 8.2 pKi = 8.2 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 365 6 0 4 4.1 COc1cccc2c1CCCC2CCCN1CCN(c2ccccn2)CC1 10.1021/jm010866v
11145007 170872 0 None -4 4 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 461 9 1 8 3.0 COc1ccc(Cl)cc1N1CCN(CCCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 10.1021/jm0009336
CHEMBL420959 170872 0 None -4 4 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligandBinding affinity towards human cloned alpha-1D-adrenoceptor using [3H]prazosin as radioligand
ChEMBL 461 9 1 8 3.0 COc1ccc(Cl)cc1N1CCN(CCCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 10.1021/jm0009336
506 9032 39 None -9 6 Rat 7.3 pKi = 7.3 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 522 6 2 9 3.0 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H](C1)C(=O)NC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm980053f
6603904 9032 39 None -9 6 Rat 7.3 pKi = 7.3 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 522 6 2 9 3.0 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H](C1)C(=O)NC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm980053f
CHEMBL19476 9032 39 None -9 6 Rat 7.3 pKi = 7.3 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 522 6 2 9 3.0 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H](C1)C(=O)NC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm980053f
46881444 14387 0 None -6 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 403 9 1 4 4.5 COc1ccccc1CCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
CHEMBL1088072 14387 0 None -6 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 403 9 1 4 4.5 COc1ccccc1CCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
44298734 203487 0 None -31 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 444 7 1 6 2.1 Cc1cc(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c(=O)[nH]1 10.1016/s0960-894x(03)00305-6
CHEMBL56489 203487 0 None -31 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 444 7 1 6 2.1 Cc1cc(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c(=O)[nH]1 10.1016/s0960-894x(03)00305-6
44300129 174207 0 None -1318 3 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 583 7 2 7 4.0 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCC(c4ccccn4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL429697 174207 0 None -1318 3 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 583 7 2 7 4.0 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCC(c4ccccn4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
10603951 213295 0 None -24 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 622 10 1 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)N(C)CCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL88448 213295 0 None -24 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 622 10 1 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)N(C)CCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
11196451 174844 0 None 1 2 Rat 6.3 pKi = 6.3 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 268 5 2 3 1.7 CCS(=O)(=O)Nc1cccc(CC2CCCN2)c1 10.1021/jm030551a
CHEMBL432451 174844 0 None 1 2 Rat 6.3 pKi = 6.3 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 268 5 2 3 1.7 CCS(=O)(=O)Nc1cccc(CC2CCCN2)c1 10.1021/jm030551a
15675860 211208 0 None -67 4 Human 5.3 pKi = 5.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 305 1 2 5 2.1 Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1 10.1016/0960-894X(95)00391-6
CHEMBL72147 211208 0 None -67 4 Human 5.3 pKi = 5.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 305 1 2 5 2.1 Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1 10.1016/0960-894X(95)00391-6
44312036 211344 1 None -7 4 Human 5.3 pKi = 5.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 305 1 2 5 2.2 CC1CN=C(Nc2ccc3nccnc3c2Br)N1 10.1016/0960-894X(95)00391-6
CHEMBL72995 211344 1 None -7 4 Human 5.3 pKi = 5.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 305 1 2 5 2.2 CC1CN=C(Nc2ccc3nccnc3c2Br)N1 10.1016/0960-894X(95)00391-6
9888164 24723 1 None -25 3 Human 6.3 pKi = 6.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 416 8 1 5 2.1 CC(C)Oc1ccccc1N1CCN(CCNC(=O)CN2CCCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL12603 24723 1 None -25 3 Human 6.3 pKi = 6.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 416 8 1 5 2.1 CC(C)Oc1ccccc1N1CCN(CCNC(=O)CN2CCCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
10770057 108849 0 None -42 3 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 610 9 2 7 4.5 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(Cl)c(Cl)c2)C3=O)CC1 10.1021/jm9905918
CHEMBL302092 108849 0 None -42 3 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 610 9 2 7 4.5 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(Cl)c(Cl)c2)C3=O)CC1 10.1021/jm9905918
10626911 108997 0 None -66 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 572 10 2 8 3.2 COc1ccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
CHEMBL302940 108997 0 None -66 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 572 10 2 8 3.2 COc1ccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
53328685 70173 0 None -5 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 435 7 0 5 3.3 COc1ccccc1N1CCN(CCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796044 70173 0 None -5 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 435 7 0 5 3.3 COc1ccccc1N1CCN(CCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
118716702 121773 0 None -5 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 396 4 0 7 1.1 COc1ccccc1N1CCN(CC2COC3(CCS(=O)(=O)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342855 121773 0 None -5 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 396 4 0 7 1.1 COc1ccccc1N1CCN(CC2COC3(CCS(=O)(=O)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
9851486 213478 0 None -436 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 592 10 2 6 6.0 CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL89685 213478 0 None -436 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 592 10 2 6 6.0 CC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
10032383 116887 0 None -812 6 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
136680387 116887 0 None -812 6 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL323579 116887 0 None -812 6 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
102 10899 48 None -48 49 Rat 7.3 pKi = 7.3 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
3659 10899 48 None -48 49 Rat 7.3 pKi = 7.3 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
8969 10899 48 None -48 49 Rat 7.3 pKi = 7.3 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
CHEMBL15245 10899 48 None -48 49 Rat 7.3 pKi = 7.3 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
DB01392 10899 48 None -48 49 Rat 7.3 pKi = 7.3 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 10.1021/jm00018a001
11801214 108998 0 None -25 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 572 10 2 8 3.2 COc1ccc(N2C(=O)c3ccc(C(=O)NC[C@@H](O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
CHEMBL302942 108998 0 None -25 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 572 10 2 8 3.2 COc1ccc(N2C(=O)c3ccc(C(=O)NC[C@@H](O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
9894665 110590 1 None -158 8 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 585 10 2 8 3.3 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL309106 110590 1 None -158 8 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 585 10 2 8 3.3 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 10.1021/jm9905918
44316098 175945 0 None -14 3 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 425 7 0 6 3.0 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)n(C)n2)CC1 10.1016/s0960-894x(00)00472-8
CHEMBL440499 175945 0 None -14 3 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptorCompound was evaluated for its binding affinity to COS cell membrane expressing the human Alpha-1D adrenergic receptor
ChEMBL 425 7 0 6 3.0 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)n(C)n2)CC1 10.1016/s0960-894x(00)00472-8
180 7189 56 None -23 40 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
200 7189 56 None -23 40 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
2160 7189 56 None -23 40 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
CHEMBL629 7189 56 None -23 40 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
DB00321 7189 56 None -23 40 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C nan
25025053 146737 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 339 4 2 5 1.2 CS(=O)(=O)c1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3799783 146737 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 339 4 2 5 1.2 CS(=O)(=O)c1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
16041629 102221 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL257097 102221 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
11092112 214407 0 None -93 9 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 485 6 0 6 4.9 O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 10.1021/jm020938y
CHEMBL95175 214407 0 None -93 9 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 485 6 0 6 4.9 O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1 10.1021/jm020938y
10698141 40599 0 None -66 3 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 561 7 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(Cl)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL142307 40599 0 None -66 3 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 561 7 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(Cl)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
3151 8244 97 None -77 26 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
945 8244 97 None -77 26 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
965 8244 97 None -77 26 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
CHEMBL219916 8244 97 None -77 26 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
DB01184 8244 97 None -77 26 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 nan
10841819 125532 0 None -691 3 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 640 7 1 8 3.9 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)N2CCC(N3CCC(C(=O)OC)(c4ccccc4)CC3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL341838 125532 0 None -691 3 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 640 7 1 8 3.9 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)N2CCC(N3CCC(C(=O)OC)(c4ccccc4)CC3)CC2)C(=O)N1 10.1021/jm990201h
2477 7532 59 None -8 29 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
36 7532 59 None -8 29 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
437 7532 59 None -8 29 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
CHEMBL49 7532 59 None -8 29 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
DB00490 7532 59 None -8 29 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 nan
11857864 151027 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 534 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4cc(F)ccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL390473 151027 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 534 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4cc(F)ccc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
277 8083 62 None -42 50 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
2913 8083 62 None -42 50 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
765 8083 62 None -42 50 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
CHEMBL516 8083 62 None -42 50 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
DB00434 8083 62 None -42 50 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 nan
44331136 116458 0 None -4 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 540 7 1 5 5.8 O=C1CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccc(NS(=O)(=O)Cc3ccccc3)cc21 10.1016/s0960-894x(98)00732-x
CHEMBL322688 116458 0 None -4 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 540 7 1 5 5.8 O=C1CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccc(NS(=O)(=O)Cc3ccccc3)cc21 10.1016/s0960-894x(98)00732-x
53328684 70172 0 None -2 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 480 9 0 7 3.4 COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccc([N+](=O)[O-])cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796043 70172 0 None -2 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 480 9 0 7 3.4 COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccc([N+](=O)[O-])cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
155521817 177421 0 None 3 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 368 5 0 5 3.0 COc1ccccc1N1CCN(C[C@H]2OCCO[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2019.02.056
CHEMBL4451283 177421 0 None 3 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 368 5 0 5 3.0 COc1ccccc1N1CCN(C[C@H]2OCCO[C@@H]2c2ccccc2)CC1 10.1016/j.ejmech.2019.02.056
11994669 18602 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1ccc(-c2ccccc2)cc1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182141 18602 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1ccc(-c2ccccc2)cc1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL214552 18602 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 391 8 1 5 4.2 COc1ccc(-c2ccccc2)cc1OCCNC[C@@H]1COc2ccccc2O1 10.1021/jm060358r
448537 167029 89 None -33 25 Human 5.3 pKi = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 167029 89 None -33 25 Human 5.3 pKi = 5.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
12488 8438 56 None -10 23 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
941361 8438 56 None -10 23 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
CHEMBL30008 8438 56 None -10 23 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
DB04841 8438 56 None -10 23 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F nan
44267890 23279 0 None -41 3 Human 5.3 pKi = 5.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 460 8 1 5 2.0 O=C(CN1CCCCC1=O)NCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL12364 23279 0 None -41 3 Human 5.3 pKi = 5.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 460 8 1 5 2.0 O=C(CN1CCCCC1=O)NCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(00)00169-4
9809007 179343 8 None -407 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL448620 179343 8 None -407 6 Human 6.3 pKi = 6.3 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
2162 48288 100 None -4 6 Human 5.3 pKi = 5.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl 10.1016/s0960-894x(99)00484-9
CHEMBL1491 48288 100 None -4 6 Human 5.3 pKi = 5.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl 10.1016/s0960-894x(99)00484-9
10580182 44247 0 None -3162 3 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 658 7 1 8 4.0 COCC1=C(C(=O)OC)C(c2cc(F)c(F)c(F)c2)N(C(=O)N2CCC(N3CCC(C(=O)OC)(c4ccccc4)CC3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL145553 44247 0 None -3162 3 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 658 7 1 8 4.0 COCC1=C(C(=O)OC)C(c2cc(F)c(F)c(F)c2)N(C(=O)N2CCC(N3CCC(C(=O)OC)(c4ccccc4)CC3)CC2)C(=O)N1 10.1021/jm990201h
10792897 174693 0 None -186 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 556 9 2 7 3.5 Cc1ccc(N2C(=O)c3ccc(C(=O)NC[C@H](O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
CHEMBL431362 174693 0 None -186 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 556 9 2 7 3.5 Cc1ccc(N2C(=O)c3ccc(C(=O)NC[C@H](O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
59151651 146628 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 289 5 2 3 2.4 N=c1c(C(N)=O)cc(Cl)cn1CCCc1ccccc1 10.1021/acs.jmedchem.5b01528
CHEMBL3799155 146628 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 289 5 2 3 2.4 N=c1c(C(N)=O)cc(Cl)cn1CCCc1ccccc1 10.1021/acs.jmedchem.5b01528
10317939 108702 0 None -4 2 Rat 7.3 pKi = 7.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 385 5 0 5 2.5 COc1cccc(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c1 10.1021/jm030944+
CHEMBL301019 108702 0 None -4 2 Rat 7.3 pKi = 7.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 385 5 0 5 2.5 COc1cccc(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c1 10.1021/jm030944+
9809007 179343 8 None -407 6 Human 6.3 pKi = 6.3 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
CHEMBL448620 179343 8 None -407 6 Human 6.3 pKi = 6.3 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
9809007 179343 8 None -407 6 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
CHEMBL448620 179343 8 None -407 6 Human 6.3 pKi = 6.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(99)00484-9
10768610 210549 0 None -24 2 Human 6.3 pKi = 6.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 532 8 2 7 2.5 COc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
CHEMBL68045 210549 0 None -24 2 Human 6.3 pKi = 6.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 532 8 2 7 2.5 COc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
1220 6975 55 None -4265 44 Rat 5.3 pKi = 5.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030944+
31 6975 55 None -4265 44 Rat 5.3 pKi = 5.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030944+
7 6975 55 None -4265 44 Rat 5.3 pKi = 5.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030944+
CHEMBL56 6975 55 None -4265 44 Rat 5.3 pKi = 5.3 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 247 5 1 2 3.4 CCCN(C1CCc2c(C1)c(O)ccc2)CCC 10.1021/jm030944+
13149 9323 36 None -91 17 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC 10.1021/acs.jmedchem.9b01465
3034396 9323 36 None -91 17 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC 10.1021/acs.jmedchem.9b01465
CHEMBL299031 9323 36 None -91 17 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins
ChEMBL 398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC 10.1021/acs.jmedchem.9b01465
10880840 18768 0 None -14 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 291 6 1 4 2.7 c1ccc(OCCNCC2COC3(CCCCC3)O2)cc1 10.1016/j.ejmech.2016.09.050
CHEMBL1183249 18768 0 None -14 3 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 291 6 1 4 2.7 c1ccc(OCCNCC2COC3(CCCCC3)O2)cc1 10.1016/j.ejmech.2016.09.050
76326540 92113 0 None 1 3 Rat 5.3 pKi = 5.3 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 274 2 4 4 1.3 NC(=O)Nc1c(O)ccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
CHEMBL2261352 92113 0 None 1 3 Rat 5.3 pKi = 5.3 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 274 2 4 4 1.3 NC(=O)Nc1c(O)ccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
44431545 94856 0 None -20 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 457 7 1 5 3.9 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234669 94856 0 None -20 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 457 7 1 5 3.9 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3)CC2)CC1 10.1016/j.bmcl.2007.04.008
10650843 210628 0 None -57 3 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 576 9 2 7 3.8 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(Cl)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL68601 210628 0 None -57 3 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 576 9 2 7 3.8 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(Cl)cc2)C3=O)CC1 10.1021/jm9905918
9959671 39445 0 None -371 3 Human 6.3 pKi = 6.3 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 0 7 5.6 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL141322 39445 0 None -371 3 Human 6.3 pKi = 6.3 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 0 7 5.6 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
44299835 205181 0 None -117 3 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 583 7 2 7 4.0 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccn4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL57691 205181 0 None -117 3 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 583 7 2 7 4.0 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccn4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
196129 74573 17 None -691 15 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC nan
CHEMBL1909065 74573 17 None -691 15 Human 6.3 pKi = 6.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC nan
44431562 94749 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(OC)c(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)c1 10.1016/j.bmcl.2007.04.008
CHEMBL234194 94749 0 None -3 4 Human 7.3 pKi = 7.3 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 517 9 1 7 3.9 COc1ccc(OC)c(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)c1 10.1016/j.bmcl.2007.04.008
10793720 210850 0 None -57 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 602 11 2 9 3.2 COc1ccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1OC 10.1021/jm9905918
CHEMBL70095 210850 0 None -57 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 602 11 2 9 3.2 COc1ccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1OC 10.1021/jm9905918
36811 8236 37 None 1 7 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
535 8236 37 None 1 7 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
937 8236 37 None 1 7 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
CHEMBL926 8236 37 None 1 7 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
DB00841 8236 37 None 1 7 Human 7.3 pKi = 7.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O nan
24894141 194188 0 None -7 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
CHEMBL493697 194188 0 None -7 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
10747021 127798 0 None -81 3 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 670 8 2 5 7.0 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccc(Cl)cc3)(c3ccc(Cl)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL356571 127798 0 None -81 3 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 670 8 2 5 7.0 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccc(Cl)cc3)(c3ccc(Cl)cc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
185076 193869 5 None -147 7 Human 6.3 pKi = 6.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
CHEMBL49137 193869 5 None -147 7 Human 6.3 pKi = 6.3 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12 10.1016/0960-894X(95)00391-6
44426404 92402 0 None -4 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 498 7 1 6 4.4 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1ccc2c(c1)OCO2 10.1016/j.bmcl.2007.04.098
CHEMBL228333 92402 0 None -4 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 498 7 1 6 4.4 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1ccc2c(c1)OCO2 10.1016/j.bmcl.2007.04.098
11000184 19824 0 None -1 6 Human 7.2 pKi = 7.2 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL1190038 19824 0 None -1 6 Human 7.2 pKi = 7.2 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL540035 19824 0 None -1 6 Human 7.2 pKi = 7.2 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1 10.1021/jm000542r
155557696 183218 0 None -12 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 377 11 2 4 3.8 OCC(CNCCOc1ccccc1)OC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.05.024
CHEMBL4558985 183218 0 None -12 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 377 11 2 4 3.8 OCC(CNCCOc1ccccc1)OC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.05.024
CHEMBL4596295 183218 0 None -12 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 377 11 2 4 3.8 OCC(CNCCOc1ccccc1)OC(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.05.024
46881443 12362 0 None -21 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 405 9 1 5 4.0 COc1cccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)c1 10.1016/j.bmcl.2010.01.030
CHEMBL1077168 12362 0 None -21 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 405 9 1 5 4.0 COc1cccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)c1 10.1016/j.bmcl.2010.01.030
10841296 43230 0 None -85 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 601 8 0 7 6.1 COC(=O)C1=C(C)N=C(C)N(Cc2cccc(CN3CCC(C(=O)OC)(c4ccccc4)CC3)c2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL144731 43230 0 None -85 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 601 8 0 7 6.1 COC(=O)C1=C(C)N=C(C)N(Cc2cccc(CN3CCC(C(=O)OC)(c4ccccc4)CC3)c2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
1547484 7727 74 None -9 20 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
654 7727 74 None -9 20 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
9072 7727 74 None -9 20 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL43064 7727 74 None -9 20 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
DB00568 7727 74 None -9 20 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
3158 63041 27 None -398 20 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 nan
CHEMBL1628227 63041 27 None -398 20 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21 nan
10606659 107310 0 None -7 3 Rat 7.2 pKi = 7.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 436 6 0 5 3.4 COc1cc2c(cc1OC)C(=O)N(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)CC2 10.1021/jm000541z
CHEMBL291305 107310 0 None -7 3 Rat 7.2 pKi = 7.2 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 436 6 0 5 3.4 COc1cc2c(cc1OC)C(=O)N(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)CC2 10.1021/jm000541z
10437624 128049 0 None -954 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 553 10 1 7 4.3 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL357828 128049 0 None -954 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 553 10 1 7 4.3 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
21509921 111235 0 None -58 24 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104091 111235 0 None -58 24 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
19085858 110929 0 None -1023 3 Human 7.2 pKi = 7.2 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 501 7 0 8 3.6 CSc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O 10.1016/s0960-894x(98)00446-6
CHEMBL309518 110929 0 None -1023 3 Human 7.2 pKi = 7.2 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 501 7 0 8 3.6 CSc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O 10.1016/s0960-894x(98)00446-6
10839105 213598 0 None -3235 3 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 2 3 4.5 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1C 10.1021/jm990612y
CHEMBL90421 213598 0 None -3235 3 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 2 3 4.5 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1C 10.1021/jm990612y
2803 7742 58 None -12 19 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
516 7742 58 None -12 19 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
704 7742 58 None -12 19 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
CHEMBL134 7742 58 None -12 19 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
DB00575 7742 58 None -12 19 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl nan
21509921 111235 0 None -58 24 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
CHEMBL3104091 111235 0 None -58 24 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)Displacement of [125I]HEAT from adrenergic alpha1D receptor (unknown origin)
ChEMBL 288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1 10.1016/j.bmcl.2013.12.024
11177467 107850 0 None -6 2 Rat 6.2 pKi = 6.2 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 414 5 0 6 2.8 CC1CN(c2ccccc2[N+](=O)[O-])CCN1CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
CHEMBL294829 107850 0 None -6 2 Rat 6.2 pKi = 6.2 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 414 5 0 6 2.8 CC1CN(c2ccccc2[N+](=O)[O-])CCN1CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
6726 8063 51 None -11 13 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
7151 8063 51 None -11 13 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
749 8063 51 None -11 13 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL648 8063 51 None -11 13 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
DB01176 8063 51 None -11 13 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 nan
11140347 211312 1 None 2 6 Human 8.2 pKi = 8.2 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL72768 211312 1 None 2 6 Human 8.2 pKi = 8.2 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1 10.1021/jm000542r
145960918 168307 0 None -7 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 427 3 1 7 3.2 COc1cc2nc(N3CCN(C(=O)C(C)(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
CHEMBL4128460 168307 0 None -7 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration methodDisplacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method
ChEMBL 427 3 1 7 3.2 COc1cc2nc(N3CCN(C(=O)C(C)(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2018.05.023
2284 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
4926 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
7281 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
CHEMBL564 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
DB00420 9956 33 None -3 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C nan
44431607 94259 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccc(Cl)c3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL233407 94259 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 509 7 1 5 4.7 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccc(Cl)c3F)CC2)CC1 10.1016/j.bmcl.2007.04.008
499 10849 18 None -7 14 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm960069a
5685 10849 18 None -7 14 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm960069a
CHEMBL25554 10849 18 None -7 14 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 10.1021/jm960069a
10095156 85318 0 None -1 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL2112073 85318 0 None -1 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)C[C@@H]21 10.1021/jm990567u
44431546 94916 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 482 7 1 6 3.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3C#N)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL234679 94916 0 None 1 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 482 7 1 6 3.8 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3C#N)CC2)CC1 10.1016/j.bmcl.2007.04.008
2419 7482 28 None -1 11 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm0307741
9 7482 28 None -1 11 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm0307741
CHEMBL13647 7482 28 None -1 11 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity at human Alpha-1D adrenergic receptor.In vitro binding affinity at human Alpha-1D adrenergic receptor.
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm0307741
2419 7482 28 None -1 11 Human 8.2 pKi = 8.2 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm960697s
9 7482 28 None -1 11 Human 8.2 pKi = 8.2 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm960697s
CHEMBL13647 7482 28 None -1 11 Human 8.2 pKi = 8.2 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm960697s
46882034 12573 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 433 10 1 5 4.8 CC(C)Oc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
CHEMBL1078773 12573 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 433 10 1 5 4.8 CC(C)Oc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
56946474 78291 0 None -7 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 403 9 1 4 4.8 COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm200421e
CHEMBL1946779 78291 0 None -7 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 403 9 1 4 4.8 COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm200421e
CHEMBL1962769 78291 0 None -7 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 403 9 1 4 4.8 COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm200421e
10599007 211294 0 None -19 8 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 435 9 1 6 4.6 COc1cccc(OC)c1OCCNC[C@@H]1Oc2ccccc2O[C@H]1c1ccc(C)cc1 10.1021/jm960069a
CHEMBL72657 211294 0 None -19 8 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 435 9 1 6 4.6 COc1cccc(OC)c1OCCNC[C@@H]1Oc2ccccc2O[C@H]1c1ccc(C)cc1 10.1021/jm960069a
10048729 195922 0 None -3 4 Human 8.2 pKi = 8.2 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 437 5 1 8 2.5 Cn1nc(Cl)c2cn3nc(NCCN4CCN(c5ccccc5)CC4)ccc3c2c1=O 10.1021/jm981006q
CHEMBL51074 195922 0 None -3 4 Human 8.2 pKi = 8.2 Binding
The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cellsThe compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells
ChEMBL 437 5 1 8 2.5 Cn1nc(Cl)c2cn3nc(NCCN4CCN(c5ccccc5)CC4)ccc3c2c1=O 10.1021/jm981006q
49781453 24639 0 None -16 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 386 2 0 3 5.3 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccccc4)cc32)CC1 10.1021/jm100652h
CHEMBL1259043 24639 0 None -16 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 386 2 0 3 5.3 CN1CCN(C2Cc3ccccc3Sc3ccc(-c4ccccc4)cc32)CC1 10.1021/jm100652h
10553701 107072 0 None -1 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 472 4 1 7 3.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccc(C#N)c54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL289166 107072 0 None -1 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 472 4 1 7 3.4 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccc(C#N)c54)c3=O)C[C@@H]21 10.1021/jm990567u
16121006 18613 0 None -316 8 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL1182182 18613 0 None -316 8 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
CHEMBL217469 18613 0 None -316 8 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm060358r
46881494 13380 0 None -6 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 421 9 1 5 4.7 COc1ccccc1OCCNCC1CSC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
CHEMBL1083182 13380 0 None -6 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 421 9 1 5 4.7 COc1ccccc1OCCNCC1CSC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
16121006 18613 0 None -316 8 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL1182182 18613 0 None -316 8 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL217469 18613 0 None -316 8 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 365 7 1 5 3.7 COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
44433348 97038 0 None -2 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 545 10 0 7 4.6 CCN([C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1)S(=O)(=O)c1ccc(OC)c(OC)c1 10.1016/j.bmcl.2007.09.051
CHEMBL238401 97038 0 None -2 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 545 10 0 7 4.6 CCN([C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1)S(=O)(=O)c1ccc(OC)c(OC)c1 10.1016/j.bmcl.2007.09.051
46882085 12587 0 None -7 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 419 10 1 5 4.4 CCOc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
CHEMBL1078953 12587 0 None -7 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 419 10 1 5 4.4 CCOc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
10530732 174830 0 None 1 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 515 4 1 6 4.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cc(C(F)(F)F)ccc54)c3=O)C[C@@H]21 10.1021/jm990567u
CHEMBL43234 174830 0 None 1 3 Rat 8.2 pKi = 8.2 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 515 4 1 6 4.6 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cc(C(F)(F)F)ccc54)c3=O)C[C@@H]21 10.1021/jm990567u
11857863 92458 0 None -2 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 534 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccc(F)cc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL228658 92458 0 None -2 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 534 9 1 6 5.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccc(F)cc4OC(C)C)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
44330880 214930 0 None -1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 371 3 0 3 4.6 O=C1OC2(CCN(CCc3cccc4ccccc34)CC2)Cc2ccccc21 10.1016/s0960-894x(98)00732-x
CHEMBL98168 214930 0 None -1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 371 3 0 3 4.6 O=C1OC2(CCN(CCc3cccc4ccccc34)CC2)Cc2ccccc21 10.1016/s0960-894x(98)00732-x
10939209 214410 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 445 6 2 5 3.5 CCC(C)c1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 10.1016/j.ejmech.2011.03.054
CHEMBL95191 214410 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 445 6 2 5 3.5 CCC(C)c1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 10.1016/j.ejmech.2011.03.054
10839106 118372 0 None -30 3 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 2 3 4.5 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H](c2ccc(F)c(F)c2)NC(=O)N1C 10.1021/jm990612y
CHEMBL328268 118372 0 None -30 3 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 2 3 4.5 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H](c2ccc(F)c(F)c2)NC(=O)N1C 10.1021/jm990612y
10481087 176245 0 None -602 3 Human 6.2 pKi = 6.2 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 499 8 1 3 6.2 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3Cl)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
CHEMBL44294 176245 0 None -602 3 Human 6.2 pKi = 6.2 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 499 8 1 3 6.2 Cc1ccc(C(C(=O)NCCCN2CCC(C#N)(c3ccccc3Cl)CC2)c2ccc(C)cc2)cc1 10.1016/s0960-894x(00)00307-3
18738382 22039 0 None -33 3 Human 6.2 pKi = 6.2 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 399 8 0 5 2.7 CC(C)Oc1ccccc1N1CCN(C/C=C/C(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL12127 22039 0 None -33 3 Human 6.2 pKi = 6.2 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 399 8 0 5 2.7 CC(C)Oc1ccccc1N1CCN(C/C=C/C(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
33630 185736 99 None -10 28 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assay
ChEMBL 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
CHEMBL47050 185736 99 None -10 28 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assay
ChEMBL 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2018.10.036
9894818 105701 0 None -138 7 Human 6.2 pKi = 6.2 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
CHEMBL279436 105701 0 None -138 7 Human 6.2 pKi = 6.2 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1 10.1021/jm980077m
12039032 105038 0 None -14 3 Human 5.2 pKi = 5.2 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 415 9 0 6 2.1 CC(C)Oc1ccccc1N1CCN(CC(=O)CC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL274529 105038 0 None -14 3 Human 5.2 pKi = 5.2 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 415 9 0 6 2.1 CC(C)Oc1ccccc1N1CCN(CC(=O)CC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
10745305 43910 0 None -169 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 553 9 0 7 5.2 COC(=O)C1=C(C)N=C(C)N(CCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL145278 43910 0 None -169 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 553 9 0 7 5.2 COC(=O)C1=C(C)N=C(C)N(CCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10816903 44467 0 None -38 3 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 571 8 2 7 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(OC)cc3C)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL145756 44467 0 None -38 3 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 571 8 2 7 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(OC)cc3C)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
10745870 43492 0 None -3090 3 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 9 2 7 2.8 COC(=O)C1=C(C)NC(=O)N(CC(=O)NCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL144938 43492 0 None -3090 3 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 9 2 7 2.8 COC(=O)C1=C(C)NC(=O)N(CC(=O)NCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
1443 8809 34 None -27 11 Rat 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
33625 8809 34 None -27 11 Rat 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
501 8809 34 None -27 11 Rat 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
CHEMBL279516 8809 34 None -27 11 Rat 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
DB08950 8809 34 None -27 11 Rat 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
ChEMBL 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 10.1021/jm00018a001
10841387 106394 0 None -190 6 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
CHEMBL284103 106394 0 None -190 6 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00019a001
10841387 106394 0 None -190 6 Human 6.2 pKi = 6.2 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm960697s
CHEMBL284103 106394 0 None -190 6 Human 6.2 pKi = 6.2 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm960697s
9830741 214635 1 None -316 7 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards Alpha1D rat adrenergic receptors, using [125I]HEAT as radioligand.Binding affinity towards Alpha1D rat adrenergic receptors, using [125I]HEAT as radioligand.
ChEMBL 475 6 1 4 5.0 C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm000085e
CHEMBL96467 214635 1 None -316 7 Rat 7.2 pKi = 7.2 Binding
Binding affinity towards Alpha1D rat adrenergic receptors, using [125I]HEAT as radioligand.Binding affinity towards Alpha1D rat adrenergic receptors, using [125I]HEAT as radioligand.
ChEMBL 475 6 1 4 5.0 C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1021/jm000085e
10792898 210724 0 None -93 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 556 9 2 7 3.5 Cc1ccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
CHEMBL69295 210724 0 None -93 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 556 9 2 7 3.5 Cc1ccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 10.1021/jm9905918
145946292 174283 0 None 19 2 Human 7.2 pKi = 7.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 382 6 2 5 2.9 CNc1ccc2c(c1)[C@H](NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4210954 174283 0 None 19 2 Human 7.2 pKi = 7.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 382 6 2 5 2.9 CNc1ccc2c(c1)[C@H](NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4299802 174283 0 None 19 2 Human 7.2 pKi = 7.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 382 6 2 5 2.9 CNc1ccc2c(c1)[C@H](NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
16041091 101996 0 None -1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL256041 101996 0 None -1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
10767606 214230 0 None -870 3 Human 7.2 pKi = 7.2 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 497 7 3 4 3.6 N#Cc1cc(F)ccc1C1CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
CHEMBL94188 214230 0 None -870 3 Human 7.2 pKi = 7.2 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 497 7 3 4 3.6 N#Cc1cc(F)ccc1C1CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
73346042 98609 5 None -630 17 Human 7.2 pKi = 7.2 Binding
Binding affinity to adrenergic alpha1D receptor (unknown origin)Binding affinity to adrenergic alpha1D receptor (unknown origin)
ChEMBL 405 9 0 8 0.9 Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O 10.1016/j.bmc.2013.05.050
CHEMBL2413153 98609 5 None -630 17 Human 7.2 pKi = 7.2 Binding
Binding affinity to adrenergic alpha1D receptor (unknown origin)Binding affinity to adrenergic alpha1D receptor (unknown origin)
ChEMBL 405 9 0 8 0.9 Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O 10.1016/j.bmc.2013.05.050
56668277 69954 0 None -616 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.3 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCC(C#N)(c4ccccc4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL1789975 69954 0 None -616 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.3 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCC(C#N)(c4ccccc4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
10555024 128667 0 None -3090 3 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 568 6 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)OCCc2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL359012 128667 0 None -3090 3 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 568 6 2 6 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CC2)OCCc2ccccc23)C1c1ccc(F)c(F)c1 10.1021/jm990201h
10626686 211098 0 None -7 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 560 9 2 7 3.3 CC(C)Oc1ccccc1N1CCN(C[C@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
CHEMBL71473 211098 0 None -7 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 560 9 2 7 3.3 CC(C)Oc1ccccc1N1CCN(C[C@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
53328506 70169 0 None -1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 459 6 0 4 4.4 O=C1CC(c2ccc(Cl)cc2)CC(=O)N1CCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796040 70169 0 None -1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 459 6 0 4 4.4 O=C1CC(c2ccc(Cl)cc2)CC(=O)N1CCCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
497 10138 8 None -61 3 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 444 7 1 6 2.1 Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C 10.1016/s0960-894x(03)00305-6
9872515 10138 8 None -61 3 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 444 7 1 6 2.1 Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C 10.1016/s0960-894x(03)00305-6
CHEMBL24777 10138 8 None -61 3 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 444 7 1 6 2.1 Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C 10.1016/s0960-894x(03)00305-6
44213730 202435 0 None -7 3 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 460 8 2 7 1.3 O=c1[nH]cc(CO)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
CHEMBL55645 202435 0 None -7 3 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 460 8 2 7 1.3 O=c1[nH]cc(CO)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 10.1016/s0960-894x(03)00305-6
CHEMBL179334 70077 0 None -3467 6 Human 6.2 pKi = 6.2 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 6.4 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)[C@H]1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
9809007 179343 8 None -407 6 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm9902032
CHEMBL448620 179343 8 None -407 6 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm9902032
10739024 76608 0 None -25 6 Rat 6.2 pKi = 6.2 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 388 4 3 8 0.9 COc1cc2nc(N3CCN[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
CHEMBL19376 76608 0 None -25 6 Rat 6.2 pKi = 6.2 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 388 4 3 8 0.9 COc1cc2nc(N3CCN[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
10697623 113944 0 None -3467 3 Human 6.2 pKi = 6.2 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 536 7 2 5 3.6 CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC1=O 10.1021/jm990612y
CHEMBL316358 113944 0 None -3467 3 Human 6.2 pKi = 6.2 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 536 7 2 5 3.6 CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC1=O 10.1021/jm990612y
44390708 71045 0 None -1230 3 Human 6.2 pKi = 6.2 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)[C@H](c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1021/jm960697s
CHEMBL180932 71045 0 None -1230 3 Human 6.2 pKi = 6.2 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)[C@H](c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1021/jm960697s
119204 191048 40 None -2 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-HEAT from human adrenergic alpha1D receptor expressed in rat-1 cellsDisplacement of [125I]-HEAT from human adrenergic alpha1D receptor expressed in rat-1 cells
ChEMBL 279 0 0 3 3.2 CN1CCc2cc3c(c4c2[C@H]1Cc1ccccc1-4)OCO3 10.1039/C7MD00629B
CHEMBL483825 191048 40 None -2 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-HEAT from human adrenergic alpha1D receptor expressed in rat-1 cellsDisplacement of [125I]-HEAT from human adrenergic alpha1D receptor expressed in rat-1 cells
ChEMBL 279 0 0 3 3.2 CN1CCc2cc3c(c4c2[C@H]1Cc1ccccc1-4)OCO3 10.1039/C7MD00629B
53328116 70158 0 None 3 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 411 5 0 4 3.4 O=C1CC(c2ccccc2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796029 70158 0 None 3 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 411 5 0 4 3.4 O=C1CC(c2ccccc2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 10.1016/j.ejmech.2011.03.054
71817545 98899 0 None -208 7 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 354 7 2 5 3.0 COc1ccc2cc[nH]c2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
CHEMBL2419765 98899 0 None -208 7 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 354 7 2 5 3.0 COc1ccc2cc[nH]c2c1OCCNC[C@H]1COc2ccccc2O1 10.1021/jm400867d
44288857 175562 0 None -83 3 Human 5.2 pKi = 5.2 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 439 9 1 6 2.9 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)Cc2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL43749 175562 0 None -83 3 Human 5.2 pKi = 5.2 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 439 9 1 6 2.9 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)Cc2ccc([N+](=O)[O-])cc2)CC1 10.1016/s0960-894x(00)00307-3
44431613 94357 0 None 1 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 529 10 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OCC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.008
CHEMBL233584 94357 0 None 1 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 529 10 1 7 3.9 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OCC4CC4)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.008
16041451 104584 0 None -1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL271913 104584 0 None -1 4 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.11.068
11757736 40521 0 None -1288 4 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 570 9 2 6 4.3 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL142243 40521 0 None -1288 4 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 570 9 2 6 4.3 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990201h
19085839 212561 0 None -208 3 Human 6.2 pKi = 6.2 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 469 6 0 7 3.2 Cc1ccc2c(c1)oc(=O)n2C1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL83041 212561 0 None -208 3 Human 6.2 pKi = 6.2 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 469 6 0 7 3.2 Cc1ccc2c(c1)oc(=O)n2C1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1 10.1016/s0960-894x(98)00446-6
71062708 161085 0 None -37 12 Mouse 5.2 pKi = 5.2 Binding
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 368 7 0 5 2.8 COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 nan
CHEMBL3986651 161085 0 None -37 12 Mouse 5.2 pKi = 5.2 Binding
Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.
ChEMBL 368 7 0 5 2.8 COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1 nan
11277157 16153 0 None 1 2 Rat 5.2 pKi = 5.2 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 267 5 2 4 1.0 CCS(=O)(=O)Nc1cccc(CC2CN=CN2)c1 10.1021/jm030551a
CHEMBL111412 16153 0 None 1 2 Rat 5.2 pKi = 5.2 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 267 5 2 4 1.0 CCS(=O)(=O)Nc1cccc(CC2CN=CN2)c1 10.1021/jm030551a
10650129 44282 0 None -162 3 Human 7.2 pKi = 7.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 540 10 0 7 5.2 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL145587 44282 0 None -162 3 Human 7.2 pKi = 7.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 540 10 0 7 5.2 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10506673 210704 0 None -72 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 542 9 2 7 3.2 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccccc2)C3=O)CC1 10.1021/jm9905918
CHEMBL69143 210704 0 None -72 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 542 9 2 7 3.2 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccccc2)C3=O)CC1 10.1021/jm9905918
127046694 146540 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 338 4 3 4 1.5 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccc(C(N)=O)c(Cl)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3798527 146540 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 338 4 3 4 1.5 N=c1c(C(N)=O)cc(Cl)cn1Cc1ccc(C(N)=O)c(Cl)c1 10.1021/acs.jmedchem.5b01528
145946451 174317 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 313 6 1 2 4.3 Fc1ccc(Cl)c(OCCNCc2cccc(Cl)c2)c1 10.1016/j.ejmech.2017.07.071
CHEMBL4218360 174317 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 313 6 1 2 4.3 Fc1ccc(Cl)c(OCCNCc2cccc(Cl)c2)c1 10.1016/j.ejmech.2017.07.071
CHEMBL4300209 174317 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 313 6 1 2 4.3 Fc1ccc(Cl)c(OCCNCc2cccc(Cl)c2)c1 10.1016/j.ejmech.2017.07.071
10318686 111060 0 None -60 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 398 7 0 6 2.9 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCC3=O)no2)CC1 10.1016/s0960-894x(02)00436-5
CHEMBL309969 111060 0 None -60 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptorDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor
ChEMBL 398 7 0 6 2.9 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCC3=O)no2)CC1 10.1016/s0960-894x(02)00436-5
15546405 103933 0 None -12 3 Human 6.2 pKi = 6.2 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 416 8 0 5 2.1 CC(C)Oc1ccccc1N1CCN(CCN(C)C(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL268030 103933 0 None -12 3 Human 6.2 pKi = 6.2 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 416 8 0 5 2.1 CC(C)Oc1ccccc1N1CCN(CCN(C)C(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
44431574 153048 0 None -6 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 505 8 1 6 4.0 COc1ccc(F)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL392066 153048 0 None -6 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 505 8 1 6 4.0 COc1ccc(F)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
9828476 213703 0 None -288 6 Human 7.2 pKi = 7.2 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 532 9 2 7 5.2 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL91022 213703 0 None -288 6 Human 7.2 pKi = 7.2 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 532 9 2 7 5.2 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
9809007 179343 8 None -407 6 Human 7.2 pKi = 7.2 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm960697s
CHEMBL448620 179343 8 None -407 6 Human 7.2 pKi = 7.2 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm960697s
25131193 92965 0 None -46 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.02.056
CHEMBL2312225 92965 0 None -46 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.02.056
24894141 194188 0 None -7 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm800461k
CHEMBL493697 194188 0 None -7 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm800461k
25131193 92965 0 None -46 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
CHEMBL2312225 92965 0 None -46 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
44300159 108612 0 None -275 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.3 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCC(C#N)(c4ccccc4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL300355 108612 0 None -275 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.3 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCC(C#N)(c4ccccc4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
9830292 174968 0 None -1778 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.3 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCC(C#N)(c4ccccc4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL433284 174968 0 None -1778 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.3 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCC(C#N)(c4ccccc4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
174174 7311 49 None -2041 14 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
260 7311 49 None -2041 14 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
320 7311 49 None -2041 14 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
CHEMBL517712 7311 49 None -2041 14 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
DB00572 7311 49 None -2041 14 Human 6.2 pKi = 6.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 289 4 1 4 1.9 OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C nan
133 9274 52 None -41 43 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 9274 52 None -41 43 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 9274 52 None -41 43 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 9274 52 None -41 43 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 9274 52 None -41 43 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
6075 156887 42 None -4 16 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 nan
CHEMBL395110 156887 42 None -4 16 Human 7.2 pKi = 7.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 nan
44331277 11248 0 None -1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 371 3 0 3 4.9 O=C1CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccccc21 10.1016/s0960-894x(98)00732-x
CHEMBL101869 11248 0 None -1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 371 3 0 3 4.9 O=C1CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccccc21 10.1016/s0960-894x(98)00732-x
53328508 70171 0 None -4 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 466 8 0 7 3.0 COc1ccccc1N1CCN(CCCN2C(=O)CC(c3ccc([N+](=O)[O-])cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796042 70171 0 None -4 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 466 8 0 7 3.0 COc1ccccc1N1CCN(CCCN2C(=O)CC(c3ccc([N+](=O)[O-])cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
56945167 78290 0 None -85 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 442 6 1 4 4.6 COc1ccccc1N1CCN(C[C@H]2CCC(c3ccccc3)(c3ccccc3)[C@@H]2O)CC1 10.1021/jm200421e
CHEMBL1946788 78290 0 None -85 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 442 6 1 4 4.6 COc1ccccc1N1CCN(C[C@H]2CCC(c3ccccc3)(c3ccccc3)[C@@H]2O)CC1 10.1021/jm200421e
CHEMBL1962757 78290 0 None -85 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 442 6 1 4 4.6 COc1ccccc1N1CCN(C[C@H]2CCC(c3ccccc3)(c3ccccc3)[C@@H]2O)CC1 10.1021/jm200421e
56945165 78293 0 None -120 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 442 6 1 4 4.6 COc1ccccc1N1CCN(C[C@H]2CCC(c3ccccc3)(c3ccccc3)[C@H]2O)CC1 10.1021/jm200421e
CHEMBL1946787 78293 0 None -120 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 442 6 1 4 4.6 COc1ccccc1N1CCN(C[C@H]2CCC(c3ccccc3)(c3ccccc3)[C@H]2O)CC1 10.1021/jm200421e
CHEMBL1962770 78293 0 None -120 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 442 6 1 4 4.6 COc1ccccc1N1CCN(C[C@H]2CCC(c3ccccc3)(c3ccccc3)[C@H]2O)CC1 10.1021/jm200421e
11350440 202328 0 None 1 2 Rat 6.2 pKi = 6.2 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 411 7 1 4 4.0 CN(CCNc1cc(Cl)ccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
CHEMBL55460 202328 0 None 1 2 Rat 6.2 pKi = 6.2 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 411 7 1 4 4.0 CN(CCNc1cc(Cl)ccc1Cl)CCN1C(=O)CC2(CCCC2)CC1=O 10.1021/jm030944+
10719222 214226 0 None -398 3 Human 7.2 pKi = 7.2 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 472 7 3 3 3.7 O=C1NC=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N1 10.1021/jm990612y
CHEMBL94167 214226 0 None -398 3 Human 7.2 pKi = 7.2 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 472 7 3 3 3.7 O=C1NC=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N1 10.1021/jm990612y
9959671 39445 0 None -371 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 0 7 5.6 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL141322 39445 0 None -371 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 0 7 5.6 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10554957 39767 0 None -1698 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 564 11 0 7 5.5 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(CCCCCN2CCC(C#N)(c3ccccc3)CC2)C(C)=N1 10.1021/jm9902032
CHEMBL141604 39767 0 None -1698 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 564 11 0 7 5.5 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(CCCCCN2CCC(C#N)(c3ccccc3)CC2)C(C)=N1 10.1021/jm9902032
9797396 19653 0 None -22 3 Human 7.2 pKi = 7.2 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 325 5 1 2 4.2 c1ccc2c(C3CCN(CCCN4CCCCC4)CC3)c[nH]c2c1 10.1016/j.bmcl.2006.05.002
CHEMBL1188811 19653 0 None -22 3 Human 7.2 pKi = 7.2 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 325 5 1 2 4.2 c1ccc2c(C3CCN(CCCN4CCCCC4)CC3)c[nH]c2c1 10.1016/j.bmcl.2006.05.002
CHEMBL537428 19653 0 None -22 3 Human 7.2 pKi = 7.2 Binding
Binding affinity to human adrenergic Alpha-1D receptorBinding affinity to human adrenergic Alpha-1D receptor
ChEMBL 325 5 1 2 4.2 c1ccc2c(C3CCN(CCCN4CCCCC4)CC3)c[nH]c2c1 10.1016/j.bmcl.2006.05.002
44324405 213540 0 None -1023 3 Human 7.2 pKi = 7.2 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 511 7 2 4 3.9 CN1C=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC1=O 10.1021/jm990612y
CHEMBL90086 213540 0 None -1023 3 Human 7.2 pKi = 7.2 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 511 7 2 4 3.9 CN1C=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC1=O 10.1021/jm990612y
53328505 70168 0 None -2 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 455 7 0 5 3.8 COc1ccccc1N1CCN(CCCN2C(=O)CC(c3ccc(Cl)cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796039 70168 0 None -2 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 455 7 0 5 3.8 COc1ccccc1N1CCN(CCCN2C(=O)CC(c3ccc(Cl)cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
155534933 178768 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 343 8 1 5 2.6 COc1ccccc1OCCNCC1(c2ccccc2)COCCO1 10.1016/j.ejmech.2019.02.056
CHEMBL4471113 178768 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 343 8 1 5 2.6 COc1ccccc1OCCNCC1(c2ccccc2)COCCO1 10.1016/j.ejmech.2019.02.056
10554745 44006 0 None -165 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 552 10 1 6 4.9 COC(=O)C1(c2ccccc2)CCN(CCCCCN2C(C)=NC(C)=C(C(N)=O)C2c2ccc(F)cc2F)CC1 10.1021/jm9902032
CHEMBL145353 44006 0 None -165 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 552 10 1 6 4.9 COC(=O)C1(c2ccccc2)CCN(CCCCCN2C(C)=NC(C)=C(C(N)=O)C2c2ccc(F)cc2F)CC1 10.1021/jm9902032
44294958 195110 0 None -301 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 554 7 3 7 1.9 NC(=O)c1ccccc1N1CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
CHEMBL50081 195110 0 None -301 3 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptorDisplacement of [3H]- prazosin from human recombinant Alpha-1D adrenergic receptor
ChEMBL 554 7 3 7 1.9 NC(=O)c1ccccc1N1CCN(CCCNC(=O)N2C(=O)NC3=C(C(=O)OC3)C2c2ccc(F)c(F)c2)CC1 10.1016/s0960-894x(99)00653-8
53328503 70166 0 None -6 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 441 6 0 5 3.4 COc1ccccc1N1CCN(CCN2C(=O)CC(c3ccc(Cl)cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796037 70166 0 None -6 3 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 441 6 0 5 3.4 COc1ccccc1N1CCN(CCN2C(=O)CC(c3ccc(Cl)cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
11334596 16192 1 None 1 2 Rat 6.2 pKi = 6.2 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 265 4 2 3 1.9 CC(c1cccc(NS(C)(=O)=O)c1)c1c[nH]cn1 10.1021/jm030551a
CHEMBL111682 16192 1 None 1 2 Rat 6.2 pKi = 6.2 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 265 4 2 3 1.9 CC(c1cccc(NS(C)(=O)=O)c1)c1c[nH]cn1 10.1021/jm030551a
44431564 155138 0 None 2 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 501 8 1 6 4.2 COc1ccc(C)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL393725 155138 0 None 2 4 Human 8.2 pKi = 8.2 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 501 8 1 6 4.2 COc1ccc(C)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
155563002 183447 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 10 1 5 4.2 COc1ccccc1OCCNC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4570387 183447 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 10 1 5 4.2 COc1ccccc1OCCNC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL4598207 183447 0 None -3 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 419 10 1 5 4.2 COc1ccccc1OCCNC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
52944615 23881 0 None -1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 431 11 1 4 5.6 Clc1cccc(Cl)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
CHEMBL1255002 23881 0 None -1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells
ChEMBL 431 11 1 4 5.6 Clc1cccc(Cl)c1OCCNCCOc1ccccc1OCc1ccccc1 10.1016/j.bmc.2010.08.002
118716715 121787 0 None -1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 521 6 0 7 3.1 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(Cl)cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342868 121787 0 None -1 4 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 521 6 0 7 3.1 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(Cl)cc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
44268966 40211 0 None -5 6 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 476 7 1 7 3.6 COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3scc(-c4ccccc4)c3c2=O)CC1 10.1016/s0960-894x(01)00159-7
CHEMBL14199 40211 0 None -5 6 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Alpha-1D adrenergic receptorBinding affinity towards human Alpha-1D adrenergic receptor
ChEMBL 476 7 1 7 3.6 COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3scc(-c4ccccc4)c3c2=O)CC1 10.1016/s0960-894x(01)00159-7
11857639 150662 1 None -2 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 492 7 1 4 5.2 CC(C)Oc1ccccc1C1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.098
CHEMBL390184 150662 1 None -2 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 492 7 1 4 5.2 CC(C)Oc1ccccc1C1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.098
44420423 90780 0 None 4 3 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 455 4 1 5 4.3 Cc1nc2c([nH]c3ccccc32)c(=O)n1CCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2006.09.034
CHEMBL220717 90780 0 None 4 3 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cellsDisplacement of [125I]BE2254 from human cloned adrenergic alpha 1D receptor expressed in HEK293 cells
ChEMBL 455 4 1 5 4.3 Cc1nc2c([nH]c3ccccc32)c(=O)n1CCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2006.09.034
155557792 181464 0 None -1 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNCC1OCCOC1(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.02.056
CHEMBL4559278 181464 0 None -1 6 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 419 9 1 5 4.0 COc1ccccc1OCCNCC1OCCOC1(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2019.02.056
76326562 112983 0 None -5 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL2261608 112983 0 None -5 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
CHEMBL3138761 112983 0 None -5 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptorDisplacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC 10.1007/s00044-004-0024-8
44428847 99068 0 None -5 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
CHEMBL242723 99068 0 None -5 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cellsDisplacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells
ChEMBL 479 5 1 9 3.3 COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC 10.1016/j.bmc.2007.01.028
10787126 91345 0 None 2 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 363 8 1 6 2.7 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(F)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153558 91345 0 None 2 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 363 8 1 6 2.7 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(F)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2220897 91345 0 None 2 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 363 8 1 6 2.7 COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(F)c2O1 10.1016/j.ejmech.2012.09.049
59151583 146678 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 275 3 2 3 2.1 Cc1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3799420 146678 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 275 3 2 3 2.1 Cc1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
44299975 108665 0 None -4 3 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 608 7 2 8 3.4 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL300766 108665 0 None -4 3 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 608 7 2 8 3.4 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
11224478 205395 0 None 21 2 Rat 8.1 pKi = 8.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 441 4 0 4 3.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(C(F)(F)F)ccc2F)CC1 10.1021/jm030944+
CHEMBL57882 205395 0 None 21 2 Rat 8.1 pKi = 8.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 441 4 0 4 3.7 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(C(F)(F)F)ccc2F)CC1 10.1021/jm030944+
2142 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
4920903 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
502 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
5775 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
CHEMBL597 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
DB00692 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1D adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
ChEMBL 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 10.1021/ml5004298
44288359 162525 0 None 1 3 Rat 8.1 pKi = 8.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 461 5 1 6 4.0 COc1cccc2c1CCC1CN(CCCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
CHEMBL40564 162525 0 None 1 3 Rat 8.1 pKi = 8.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 461 5 1 6 4.0 COc1cccc2c1CCC1CN(CCCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC21 10.1021/jm990567u
9906677 107822 0 None 11 3 Rat 8.1 pKi = 8.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 355 4 0 4 2.3 O=C1CCC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
CHEMBL294646 107822 0 None 11 3 Rat 8.1 pKi = 8.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 355 4 0 4 2.3 O=C1CCC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 10.1021/jm030944+
10478121 177581 0 None -14 5 Rat 8.1 pKi = 8.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 435 6 0 7 3.1 COc1cc2ncn(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC 10.1021/jm000541z
CHEMBL445325 177581 0 None -14 5 Rat 8.1 pKi = 8.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 435 6 0 7 3.1 COc1cc2ncn(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC 10.1021/jm000541z
9865254 75450 0 None 6 5 Human 8.1 pKi = 8.1 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 391 4 0 4 2.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)c(F)c2)CC1 10.1021/jm0491391
CHEMBL192099 75450 0 None 6 5 Human 8.1 pKi = 8.1 Binding
Binding affinity for human Alpha-1D adrenergic receptorBinding affinity for human Alpha-1D adrenergic receptor
ChEMBL 391 4 0 4 2.8 O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)c(F)c2)CC1 10.1021/jm0491391
11016418 112899 0 None -12 9 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 488 6 0 7 4.2 Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
CHEMBL313424 112899 0 None -12 9 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 488 6 0 7 4.2 Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
10617200 33206 0 None -1 5 Human 8.1 pKi = 8.1 Binding
Ability to displace [3H]prazosin from human cloned Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 341 5 2 5 2.4 O[C@@H]1[C@H](NC[C@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1 10.1021/jm991065j
CHEMBL135973 33206 0 None -1 5 Human 8.1 pKi = 8.1 Binding
Ability to displace [3H]prazosin from human cloned Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 341 5 2 5 2.4 O[C@@H]1[C@H](NC[C@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1 10.1021/jm991065j
129211 10521 78 None -1 16 Human 8.1 pKi = 8.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
2562 10521 78 None -1 16 Human 8.1 pKi = 8.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
488 10521 78 None -1 16 Human 8.1 pKi = 8.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
CHEMBL836 10521 78 None -1 16 Human 8.1 pKi = 8.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
DB00706 10521 78 None -1 16 Human 8.1 pKi = 8.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10.1021/jm960697s
44298626 202256 0 None -25 3 Human 8.1 pKi = 8.1 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 427 7 1 7 1.4 Cc1n[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
CHEMBL55290 202256 0 None -25 3 Human 8.1 pKi = 8.1 Binding
Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorInhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptor
ChEMBL 427 7 1 7 1.4 Cc1n[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c1=O 10.1016/s0960-894x(03)00305-6
11857794 92443 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 562 9 1 5 5.7 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cccc(OC(F)F)c1 10.1016/j.bmcl.2007.04.098
CHEMBL228553 92443 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 562 9 1 5 5.7 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cccc(OC(F)F)c1 10.1016/j.bmcl.2007.04.098
10507220 128054 0 None -1380 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 0 7 5.6 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1F 10.1021/jm9902032
CHEMBL357842 128054 0 None -1380 3 Human 6.2 pKi = 6.2 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 567 10 0 7 5.6 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1F 10.1021/jm9902032
9904606 16158 0 None -8 4 Rat 6.2 pKi = 6.2 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 3 1 3 2.3 CN(c1cccc2c1CCCC2c1c[nH]cn1)S(C)(=O)=O 10.1021/jm030551a
CHEMBL111463 16158 0 None -8 4 Rat 6.2 pKi = 6.2 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 305 3 1 3 2.3 CN(c1cccc2c1CCCC2c1c[nH]cn1)S(C)(=O)=O 10.1021/jm030551a
441383 27105 57 None -9 17 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL1306 27105 57 None -9 17 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
19085829 212625 0 None -263 3 Human 7.2 pKi = 7.2 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 473 6 0 7 3.0 O=C1c2cc(F)ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL83592 212625 0 None -263 3 Human 7.2 pKi = 7.2 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 473 6 0 7 3.0 O=C1c2cc(F)ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
11440979 204439 0 None 8 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 400 5 1 6 1.3 COc1ccccc1N1CCN(CCN2C(=O)CC3(CCNCC3)CC2=O)CC1 10.1021/jm030944+
CHEMBL57098 204439 0 None 8 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 400 5 1 6 1.3 COc1ccccc1N1CCN(CCN2C(=O)CC3(CCNCC3)CC2=O)CC1 10.1021/jm030944+
10622830 109203 0 None -5 3 Rat 7.1 pKi = 7.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 437 6 1 6 3.2 COc1cc2c(cc1OC)C(=O)N(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)CN2 10.1021/jm000541z
CHEMBL303988 109203 0 None -5 3 Rat 7.1 pKi = 7.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 437 6 1 6 3.2 COc1cc2c(cc1OC)C(=O)N(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)CN2 10.1021/jm000541z
10791843 170179 0 None -309 3 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 511 7 2 4 3.7 CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@H](c2ccc(F)c(F)c2)NC1=O 10.1021/jm990612y
CHEMBL419497 170179 0 None -309 3 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 511 7 2 4 3.7 CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@H](c2ccc(F)c(F)c2)NC1=O 10.1021/jm990612y
44289112 171676 0 None -93 3 Human 6.2 pKi = 6.2 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 495 9 1 4 5.5 COc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(C)cc2)c2ccc(C)cc2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL42220 171676 0 None -93 3 Human 6.2 pKi = 6.2 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 495 9 1 4 5.5 COc1ccccc1C1(C#N)CCN(CCCNC(=O)C(c2ccc(C)cc2)c2ccc(C)cc2)CC1 10.1016/s0960-894x(00)00307-3
10578990 210620 0 None -48 3 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 572 10 2 8 3.2 COc1ccccc1N1C(=O)c2ccc(C(=O)NCC(O)CN3CCN(c4ccccc4OC(C)C)CC3)cc2C1=O 10.1021/jm9905918
CHEMBL68565 210620 0 None -48 3 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 572 10 2 8 3.2 COc1ccccc1N1C(=O)c2ccc(C(=O)NCC(O)CN3CCN(c4ccccc4OC(C)C)CC3)cc2C1=O 10.1021/jm9905918
16041092 102155 0 None 1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL256804 102155 0 None 1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.11.068
518 10384 1 None -5 6 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl 10.1021/jm00019a001
9839317 10384 1 None -5 6 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl 10.1021/jm00019a001
CHEMBL123138 10384 1 None -5 6 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsInhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl 10.1021/jm00019a001
53328507 70170 0 None -1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 469 8 0 5 4.2 COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccc(Cl)cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796041 70170 0 None -1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 469 8 0 5 4.2 COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccc(Cl)cc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
25130878 194056 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 313 7 1 4 2.8 c1ccc(OCCNC[C@@H]2COC[C@H](c3ccccc3)O2)cc1 10.1021/jm800461k
CHEMBL492835 194056 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 313 7 1 4 2.8 c1ccc(OCCNC[C@@H]2COC[C@H](c3ccccc3)O2)cc1 10.1021/jm800461k
71521478 92966 0 None -1318 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNC[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
CHEMBL2312226 92966 0 None -1318 3 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 449 10 1 6 4.0 COc1cccc(OC)c1OCCNC[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 10.1021/jm301525w
44329027 10940 0 None -37 6 Human 6.1 pKi = 6.1 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 637 13 3 7 4.9 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COC)N1 10.1016/s0960-894x(99)00484-9
CHEMBL100045 10940 0 None -37 6 Human 6.1 pKi = 6.1 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 637 13 3 7 4.9 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COC)N1 10.1016/s0960-894x(99)00484-9
19085926 212322 0 None -724 3 Human 7.1 pKi = 7.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 469 6 0 7 3.2 Cc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O 10.1016/s0960-894x(98)00446-6
CHEMBL81006 212322 0 None -724 3 Human 7.1 pKi = 7.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 469 6 0 7 3.2 Cc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O 10.1016/s0960-894x(98)00446-6
9872440 109043 0 None -81 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 556 9 2 7 3.5 Cc1cccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)c1 10.1021/jm9905918
CHEMBL303248 109043 0 None -81 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 556 9 2 7 3.5 Cc1cccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)c1 10.1021/jm9905918
9934955 79051 0 None -20 6 Human 7.1 pKi = 7.1 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 482 5 2 9 2.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
CHEMBL19826 79051 0 None -20 6 Human 7.1 pKi = 7.1 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
ChEMBL 482 5 2 9 2.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
16040907 104659 0 None 2 4 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL272340 104659 0 None 2 4 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.11.068
56649649 74632 0 None -85 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 480 8 0 5 4.6 COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
CHEMBL1910140 74632 0 None -85 8 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]prazosin from Alpha-1D receptor expressed in HEK293 EBNA cells by radioligand binding assay
ChEMBL 480 8 0 5 4.6 COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1 10.1016/j.ejmech.2011.06.023
11474564 108383 0 None 31 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 383 4 0 4 3.1 Cc1ccc(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c(C)c1 10.1021/jm030944+
CHEMBL298808 108383 0 None 31 2 Rat 7.1 pKi = 7.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 383 4 0 4 3.1 Cc1ccc(N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2)c(C)c1 10.1021/jm030944+
2812 11551 101 None -40 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -40 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
9916549 128342 0 None -1023 4 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 592 10 3 8 3.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
CHEMBL358595 128342 0 None -1023 4 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 592 10 3 8 3.1 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
10508016 213935 0 None -20 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 613 9 2 5 7.7 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2ccccc2c1 10.1021/jm980077m
CHEMBL92322 213935 0 None -20 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 613 9 2 5 7.7 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2ccccc2c1 10.1021/jm980077m
2105 9828 37 None -72 32 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
47811 9828 37 None -72 32 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
48 9828 37 None -72 32 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
CHEMBL531 9828 37 None -72 32 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
DB01186 9828 37 None -72 32 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 nan
19085881 212547 0 None -478 3 Human 7.1 pKi = 7.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 0 9 2.8 O=C1c2ccc([N+](=O)[O-])cc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL82877 212547 0 None -478 3 Human 7.1 pKi = 7.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 500 7 0 9 2.8 O=C1c2ccc([N+](=O)[O-])cc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
9915831 108881 0 None -50 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 560 9 2 7 3.3 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
CHEMBL302246 108881 0 None -50 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 560 9 2 7 3.3 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 10.1021/jm9905918
9960311 210643 0 None -25 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 598 9 2 7 4.5 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(C(C)(C)C)cc2)C3=O)CC1 10.1021/jm9905918
CHEMBL68699 210643 0 None -25 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligandBinding affinity towards cloned human alpha-1D adrenergic receptor was determined using [125]-HEAT as radioligand
ChEMBL 598 9 2 7 4.5 CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(C(C)(C)C)cc2)C3=O)CC1 10.1021/jm9905918
53328873 70178 0 None -1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 447 6 0 5 3.2 COc1ccccc1N1CCN(CCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796049 70178 0 None -1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 447 6 0 5 3.2 COc1ccccc1N1CCN(CCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
155536203 183186 0 None -1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 403 10 1 4 4.6 c1ccc(OCCNCC[C@@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4473623 183186 0 None -1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 403 10 1 4 4.6 c1ccc(OCCNCC[C@@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4596045 183186 0 None -1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 403 10 1 4 4.6 c1ccc(OCCNCC[C@@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
44362867 44421 0 None -165 3 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 658 8 2 5 6.9 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3cc(C)cc(C)c3)(c3cc(C)cc(C)c3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL145719 44421 0 None -165 3 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 658 8 2 5 6.9 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3cc(C)cc(C)c3)(c3cc(C)cc(C)c3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
11203294 82606 3 None -1174 5 Human 5.1 pKi = 5.1 Binding
GPCRScan assay: inhibition of Alpha1DGPCRScan assay: inhibition of Alpha1D
ChEMBL 526 9 1 5 5.7 Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1 10.6019/CHEMBL5058642
CHEMBL2048623 82606 3 None -1174 5 Human 5.1 pKi = 5.1 Binding
GPCRScan assay: inhibition of Alpha1DGPCRScan assay: inhibition of Alpha1D
ChEMBL 526 9 1 5 5.7 Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1 10.6019/CHEMBL5058642
10841387 106394 0 None -190 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
CHEMBL284103 106394 0 None -190 6 Human 6.1 pKi = 6.1 Binding
Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptorBinding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
ChEMBL 607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm980077m
118717462 121922 0 None -10 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 444 12 2 6 6.3 COc1cccc2c(NCCCCCCCNc3ccnc4c(OC)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
CHEMBL3343984 121922 0 None -10 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cellsDisplacement of [3H]-prazosin from human alpha1D adrenergic receptor transfected in COS1 cells
ChEMBL 444 12 2 6 6.3 COc1cccc2c(NCCCCCCCNc3ccnc4c(OC)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
9817256 211017 0 None -4 4 Human 5.1 pKi = 5.1 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 283 5 2 6 0.5 COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1021/jm000542r
CHEMBL71001 211017 0 None -4 4 Human 5.1 pKi = 5.1 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 283 5 2 6 0.5 COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1 10.1021/jm000542r
11203294 82606 3 None -1174 5 Human 5.1 pKi = 5.1 Binding
GPCRScan assay: inhibition of Alpha1DGPCRScan assay: inhibition of Alpha1D
ChEMBL 526 9 1 5 5.7 Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1 10.6019/CHEMBL5058642
CHEMBL2048623 82606 3 None -1174 5 Human 5.1 pKi = 5.1 Binding
GPCRScan assay: inhibition of Alpha1DGPCRScan assay: inhibition of Alpha1D
ChEMBL 526 9 1 5 5.7 Cc1cc(OC2CCS(=O)(=O)CC2)cc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1 10.6019/CHEMBL5058642
118717462 121922 0 None -10 4 Human 6.1 pKi = 6.1 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 444 12 2 6 6.3 COc1cccc2c(NCCCCCCCNc3ccnc4c(OC)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
CHEMBL3343984 121922 0 None -10 4 Human 6.1 pKi = 6.1 Binding
Binding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptorBinding affinity to human alpha1D adrenergic receptor transfected in COS1 cells assessed as compound required to occupy 50% of receptor
ChEMBL 444 12 2 6 6.3 COc1cccc2c(NCCCCCCCNc3ccnc4c(OC)cccc34)ccnc12 10.1016/j.bmc.2014.09.017
19085914 212604 0 None -1174 3 Human 7.1 pKi = 7.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 485 7 0 8 2.9 COc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O 10.1016/s0960-894x(98)00446-6
CHEMBL83340 212604 0 None -1174 3 Human 7.1 pKi = 7.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 485 7 0 8 2.9 COc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O 10.1016/s0960-894x(98)00446-6
44431618 151682 0 None -5 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 488 8 1 7 3.3 COc1ccncc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL391017 151682 0 None -5 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 488 8 1 7 3.3 COc1ccncc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
53328687 70176 0 None 1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 483 8 0 5 4.4 COc1ccc(Cl)cc1N1CCN(CCCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796047 70176 0 None 1 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 483 8 0 5 4.4 COc1ccc(Cl)cc1N1CCN(CCCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
9934955 79051 0 None -22 6 Rat 7.1 pKi = 7.1 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 482 5 2 9 2.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
CHEMBL19826 79051 0 None -22 6 Rat 7.1 pKi = 7.1 Binding
Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptorCompound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor
ChEMBL 482 5 2 9 2.1 COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC 10.1021/jm980053f
9809007 179343 8 None -407 6 Human 6.1 pKi = 6.1 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
CHEMBL448620 179343 8 None -407 6 Human 6.1 pKi = 6.1 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
ChEMBL 608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm00010a001
10769621 125771 0 None -2570 3 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 8 2 7 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(OC(C)=O)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL342543 125771 0 None -2570 3 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 8 2 7 4.1 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(OC(C)=O)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
10626843 175444 0 None -158 3 Human 7.1 pKi = 7.1 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 568 10 0 8 5.0 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3C(=O)OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL436407 175444 0 None -158 3 Human 7.1 pKi = 7.1 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 568 10 0 8 5.0 COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3C(=O)OC)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
463 8187 22 None -50 13 Human 7.1 pKi = 7.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
6918097 8187 22 None -50 13 Human 7.1 pKi = 7.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
837 8187 22 None -50 13 Human 7.1 pKi = 7.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
CHEMBL2051956 8187 22 None -50 13 Human 7.1 pKi = 7.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
DB14068 8187 22 None -50 13 Human 7.1 pKi = 7.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960697s
10621592 91346 0 None -13 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2c(OC)cccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153559 91346 0 None -13 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2c(OC)cccc2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2220898 91346 0 None -13 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 375 9 1 7 2.5 COc1cccc(OC)c1OCCNC[C@H]1COc2c(OC)cccc2O1 10.1016/j.ejmech.2012.09.049
75306277 116031 0 None -398 23 Human 6.1 pKi = 6.1 Binding
Binding affinity to adrenergic alpha1D receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha1D receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
CHEMBL3217984 116031 0 None -398 23 Human 6.1 pKi = 6.1 Binding
Binding affinity to adrenergic alpha1D receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha1D receptor (unknown origin) by PDSP assay
ChEMBL 308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3 10.1039/C2MD00311B
10089254 106757 0 None -50 3 Human 6.1 pKi = 6.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 350 7 1 3 3.5 O=C(CCCN1CCC(NC(=O)c2ccccc2)CC1)c1ccccc1 10.1021/jm960697s
CHEMBL286591 106757 0 None -50 3 Human 6.1 pKi = 6.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 350 7 1 3 3.5 O=C(CCCN1CCC(NC(=O)c2ccccc2)CC1)c1ccccc1 10.1021/jm960697s
118716704 121775 0 None -1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 423 5 0 6 3.2 COc1ccccc1N1CCN(CC2COC3(CCN(c4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342857 121775 0 None -1 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 423 5 0 6 3.2 COc1ccccc1N1CCN(CC2COC3(CCN(c4ccccc4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
44268966 40211 0 None -6 6 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 476 7 1 7 3.6 COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3scc(-c4ccccc4)c3c2=O)CC1 10.1016/s0960-894x(01)00159-7
CHEMBL14199 40211 0 None -6 6 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards rat Alpha-1D adrenergic receptorBinding affinity towards rat Alpha-1D adrenergic receptor
ChEMBL 476 7 1 7 3.6 COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3scc(-c4ccccc4)c3c2=O)CC1 10.1016/s0960-894x(01)00159-7
11505007 97039 0 None 4 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 557 9 1 7 4.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL238402 97039 0 None 4 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 557 9 1 7 4.1 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
10822173 127082 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 3 1 2 3.3 CCC(c1c[nH]cn1)c1sccc1C 10.1021/jm0003891
CHEMBL1744267 127082 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 3 1 2 3.3 CCC(c1c[nH]cn1)c1sccc1C 10.1021/jm0003891
CHEMBL352746 127082 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 206 3 1 2 3.3 CCC(c1c[nH]cn1)c1sccc1C 10.1021/jm0003891
3584 10549 64 None -1 14 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
5401 10549 64 None -1 14 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
7302 10549 64 None -1 14 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
CHEMBL611 10549 64 None -1 14 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
DB01162 10549 64 None -1 14 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 nan
59151621 146631 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 320 3 2 4 2.3 N#Cc1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
CHEMBL3799166 146631 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 320 3 2 4 2.3 N#Cc1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
46934789 23463 0 None 2 4 Human 8.1 pKi = 8.1 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 479 7 0 7 2.6 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
CHEMBL1242819 23463 0 None 2 4 Human 8.1 pKi = 8.1 Binding
Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration techniqueDisplacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique
ChEMBL 479 7 0 7 2.6 COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CCCC3=O)(c3ccccc3)O2)CC1 10.1016/j.ejmech.2010.05.023
44431602 154372 0 None -5 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 525 7 1 5 5.2 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL393104 154372 0 None -5 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 525 7 1 5 5.2 CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2007.04.008
11857862 148832 0 None 2 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 538 10 1 6 4.8 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL387833 148832 0 None 2 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 538 10 1 6 4.8 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
2419 7482 28 None -3 11 Rat 8.1 pKi = 8.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm030944+
9 7482 28 None -3 11 Rat 8.1 pKi = 8.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm030944+
CHEMBL13647 7482 28 None -3 11 Rat 8.1 pKi = 8.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 10.1021/jm030944+
144096995 171275 0 None 3 3 Human 8.1 pKi = 8.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 371 8 1 4 3.1 CS(=O)(=O)c1ccccc1CCNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
CHEMBL4214499 171275 0 None 3 3 Human 8.1 pKi = 8.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 371 8 1 4 3.1 CS(=O)(=O)c1ccccc1CCNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
9848303 118357 0 None -2 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 487 6 1 6 3.8 Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 10.1016/j.bmc.2012.10.049
CHEMBL328187 118357 0 None -2 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysisDisplacement of [3H]prazosine from rat alpha1D adrenoceptor expressed in CHO cells after 20 mins by scintillation counting analysis
ChEMBL 487 6 1 6 3.8 Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 10.1016/j.bmc.2012.10.049
9848303 118357 0 None -2 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 487 6 1 6 3.8 Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 10.1021/jm100652h
CHEMBL328187 118357 0 None -2 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 487 6 1 6 3.8 Cn1cc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)nn1 10.1021/jm100652h
44288468 175160 0 None -1 3 Rat 8.1 pKi = 8.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1C1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC1CC2 10.1021/jm990567u
CHEMBL434591 175160 0 None -1 3 Rat 8.1 pKi = 8.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell
ChEMBL 447 4 1 6 3.6 COc1cccc2c1C1CN(CCn3c(=O)[nH]c4c(sc5ccccc54)c3=O)CC1CC2 10.1021/jm990567u
59151563 146617 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 291 4 2 4 1.8 COc1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
CHEMBL3799089 146617 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 291 4 2 4 1.8 COc1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 10.1021/acs.jmedchem.5b01528
16040907 104659 0 None 2 4 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL272340 104659 0 None 2 4 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.11.068
10678591 65856 5 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 164 2 1 2 2.1 c1csc(Cc2c[nH]cn2)c1 10.1021/jm0003891
CHEMBL1203849 65856 5 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 164 2 1 2 2.1 c1csc(Cc2c[nH]cn2)c1 10.1021/jm0003891
CHEMBL169599 65856 5 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
ChEMBL 164 2 1 2 2.1 c1csc(Cc2c[nH]cn2)c1 10.1021/jm0003891
11394353 107666 0 None 9 3 Rat 8.1 pKi = 8.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 361 4 0 3 4.1 Clc1ccccc1N1CCN(CCN2CCC3(CCCC3)CC2)CC1 10.1021/jm030944+
CHEMBL293734 107666 0 None 9 3 Rat 8.1 pKi = 8.1 Binding
Binding affinity to the adrenergic receptor alpha-1D of rat aortaBinding affinity to the adrenergic receptor alpha-1D of rat aorta
ChEMBL 361 4 0 3 4.1 Clc1ccccc1N1CCN(CCN2CCC3(CCCC3)CC2)CC1 10.1021/jm030944+
73453 36389 24 None -12 17 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
CHEMBL1385840 36389 24 None -12 17 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 nan
11857861 201559 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 520 10 1 6 4.5 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL538397 201559 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 520 10 1 6 4.5 COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
71454865 91378 0 None -8 7 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 361 8 2 7 2.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(O)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2153551 91378 0 None -8 7 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 361 8 2 7 2.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(O)c2O1 10.1016/j.ejmech.2012.09.049
CHEMBL2221145 91378 0 None -8 7 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counterDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins by liquid scintillation counter
ChEMBL 361 8 2 7 2.2 COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(O)c2O1 10.1016/j.ejmech.2012.09.049
9866614 21487 1 None -120 3 Human 7.1 pKi = 7.1 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 416 9 1 5 2.1 CC(C)Oc1ccccc1N1CCN(CCCNC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
CHEMBL12062 21487 1 None -120 3 Human 7.1 pKi = 7.1 Binding
Binding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranesBinding affinity for human Alpha-1D adrenergic receptor expressed in COS cell membranes
ChEMBL 416 9 1 5 2.1 CC(C)Oc1ccccc1N1CCN(CCCNC(=O)CN2CCCCC2=O)CC1 10.1016/s0960-894x(00)00169-4
10393665 40696 0 None -151 3 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 593 9 2 9 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
CHEMBL142383 40696 0 None -151 3 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 593 9 2 9 3.4 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
10767607 113906 0 None -4786 3 Human 6.1 pKi = 6.1 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 497 7 3 4 3.4 N#CC1(c2ccc(F)cc2)CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
CHEMBL316100 113906 0 None -4786 3 Human 6.1 pKi = 6.1 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 497 7 3 4 3.4 N#CC1(c2ccc(F)cc2)CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 10.1021/jm990612y
487 10406 21 None -218 12 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960069a
60602 10406 21 None -218 12 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960069a
CHEMBL405355 10406 21 None -218 12 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960069a
DB09239 10406 21 None -218 12 Rat 7.1 pKi = 7.1 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
ChEMBL 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 10.1021/jm960069a
59151612 146415 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 241 2 2 3 1.8 CC(C)(C)Cn1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
CHEMBL3797685 146415 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 241 2 2 3 1.8 CC(C)(C)Cn1cc(Cl)cc(C(N)=O)c1=N 10.1021/acs.jmedchem.5b01528
71817861 109183 0 None -2 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 356 7 2 6 2.5 COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)NCC2 10.1021/jm400867d
CHEMBL3039699 109183 0 None -2 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 356 7 2 6 2.5 COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)NCC2 10.1021/jm400867d
CHEMBL3217244 109183 0 None -2 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 minsDisplacement of [3H]prazosin from human alpha-1D adrenoreceptor expressed in CHO cells after 30 mins
ChEMBL 356 7 2 6 2.5 COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)NCC2 10.1021/jm400867d
71521480 93036 0 None -208 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNC[C@H]2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm301525w
CHEMBL2312538 93036 0 None -208 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 minsDisplacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins
ChEMBL 389 8 1 4 4.0 c1ccc(OCCNC[C@H]2COCC(c3ccccc3)(c3ccccc3)O2)cc1 10.1021/jm301525w
11782656 35856 0 None -436 6 Human 7.1 pKi = 7.1 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 336 9 1 4 3.8 COc1cccc2c(CCCNCCOc3ccccn3)cccc12 10.1021/jm010866v
CHEMBL138109 35856 0 None -436 6 Human 7.1 pKi = 7.1 Binding
Binding affinity towarda alpha-1D adrenergic receptorBinding affinity towarda alpha-1D adrenergic receptor
ChEMBL 336 9 1 4 3.8 COc1cccc2c(CCCNCCOc3ccccn3)cccc12 10.1021/jm010866v
10622156 206847 0 None -1 3 Rat 7.1 pKi = 7.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 422 6 0 5 3.7 COc1cc2c(cc1OC)CN(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)CC2 10.1021/jm000541z
CHEMBL59575 206847 0 None -1 3 Rat 7.1 pKi = 7.1 Binding
Binding affinity to rat alpha-1D adrenergic receptor expressed in LTK cellsBinding affinity to rat alpha-1D adrenergic receptor expressed in LTK cells
ChEMBL 422 6 0 5 3.7 COc1cc2c(cc1OC)CN(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)CC2 10.1021/jm000541z
10297 33885 30 None -31 43 Rat 5.1 pKi = 5.1 Binding
Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (5.5 -13)Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (5.5 -13)
ChEMBL 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 10.1021/jm025550h
CHEMBL136560 33885 30 None -31 43 Rat 5.1 pKi = 5.1 Binding
Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (5.5 -13)Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (5.5 -13)
ChEMBL 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 10.1021/jm025550h
2435 7509 100 None -28 12 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
395 7509 100 None -28 12 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
520 7509 100 None -28 12 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
5386 7509 100 None -28 12 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
CHEMBL844 7509 100 None -28 12 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
DB00484 7509 100 None -28 12 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 nan
9913449 113229 1 None -46 3 Human 7.1 pKi = 7.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 489 6 0 7 3.5 O=C1c2cc(Cl)ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL313990 113229 1 None -46 3 Human 7.1 pKi = 7.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 489 6 0 7 3.5 O=C1c2cc(Cl)ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 10.1016/s0960-894x(98)00446-6
76319344 92112 0 None -29 3 Rat 5.1 pKi = 5.1 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 289 2 3 5 2.0 COC(=O)Nc1c(O)ccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
CHEMBL2261351 92112 0 None -29 3 Rat 5.1 pKi = 5.1 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 289 2 3 5 2.0 COC(=O)Nc1c(O)ccc2c1CCCC2C1=NCCN1 10.1007/s00044-004-0020-z
162265 209053 22 None -5 44 Rat 5.1 pKi = 5.1 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1007/s00044-004-0020-z
4786 209053 22 None -5 44 Rat 5.1 pKi = 5.1 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1007/s00044-004-0020-z
CHEMBL61006 209053 22 None -5 44 Rat 5.1 pKi = 5.1 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1007/s00044-004-0020-z
162265 209053 22 None -5 44 Rat 5.1 pKi = 5.1 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1021/jm030551a
4786 209053 22 None -5 44 Rat 5.1 pKi = 5.1 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1021/jm030551a
CHEMBL61006 209053 22 None -5 44 Rat 5.1 pKi = 5.1 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 10.1021/jm030551a
44426405 92444 0 None -2 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 562 9 1 5 5.7 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc(OC(F)F)cc1 10.1016/j.bmcl.2007.04.098
CHEMBL228554 92444 0 None -2 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 562 9 1 5 5.7 O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc(OC(F)F)cc1 10.1016/j.bmcl.2007.04.098
11857862 92452 0 None -2 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 538 10 1 6 4.8 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
11857862 92452 0 None -2 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 538 10 1 6 4.8 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
CHEMBL228607 92452 0 None -2 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 538 10 1 6 4.8 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.04.098
CHEMBL228607 92452 0 None -2 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 538 10 1 6 4.8 COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC 10.1016/j.bmcl.2007.09.051
145947479 174421 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 396 6 2 5 2.0 NC(=O)c1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4210948 174421 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 396 6 2 5 2.0 NC(=O)c1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4301647 174421 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 396 6 2 5 2.0 NC(=O)c1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
11857639 92523 1 None -61 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 492 7 1 4 5.2 CC(C)Oc1ccccc1C1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.098
CHEMBL229084 92523 1 None -61 4 Human 7.1 pKi = 7.1 Binding
Binding affinity to human cloned adrenergic alpha-1d receptorBinding affinity to human cloned adrenergic alpha-1d receptor
ChEMBL 492 7 1 4 5.2 CC(C)Oc1ccccc1C1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.04.098
10603739 23161 0 None -109 3 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 607 10 2 9 3.8 CCC1=C(C(=O)OC)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
CHEMBL123012 23161 0 None -109 3 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 607 10 2 9 3.8 CCC1=C(C(=O)OC)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 10.1021/jm990200p
155525650 183417 0 None -16 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 9 1 4 4.2 c1ccc(OCCNC[C@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4457585 183417 0 None -16 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 9 1 4 4.2 c1ccc(OCCNC[C@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4597956 183417 0 None -16 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 389 9 1 4 4.2 c1ccc(OCCNC[C@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
3191 109635 97 None -14 25 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL305660 109635 97 None -14 25 Human 6.1 pKi = 6.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
10916464 210932 0 None -1 5 Human 6.1 pKi = 6.1 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 287 4 2 5 1.2 CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1 10.1021/jm000542r
CHEMBL70563 210932 0 None -1 5 Human 6.1 pKi = 6.1 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 287 4 2 5 1.2 CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1 10.1021/jm000542r
2398 7741 62 None -1 29 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
2801 7741 62 None -1 29 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
701 7741 62 None -1 29 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
CHEMBL415 7741 62 None -1 29 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
DB01242 7741 62 None -1 29 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C nan
127046608 146682 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 227 3 2 3 1.1 N=c1c(C(N)=O)cccn1Cc1ccccc1 10.1021/acs.jmedchem.5b01528
CHEMBL3799440 146682 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 227 3 2 3 1.1 N=c1c(C(N)=O)cccn1Cc1ccccc1 10.1021/acs.jmedchem.5b01528
10601065 119085 0 None -954 3 Human 6.1 pKi = 6.1 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 488 7 4 4 2.8 O=C1NC=C(C(=O)NCCCN2CCC(O)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N1 10.1021/jm990612y
CHEMBL329143 119085 0 None -954 3 Human 6.1 pKi = 6.1 Binding
Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.
ChEMBL 488 7 4 4 2.8 O=C1NC=C(C(=O)NCCCN2CCC(O)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N1 10.1021/jm990612y
10793261 127831 0 None -6165 4 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 575 10 3 8 3.0 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1021/jm990200p
CHEMBL356829 127831 0 None -6165 4 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 575 10 3 8 3.0 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C2=C(C)NC(C)=C(C(N)=O)C2c2ccc([N+](=O)[O-])cc2)CC1 10.1021/jm990200p
155515301 176746 0 None -7 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 444 6 0 5 4.2 COc1ccccc1N1CCN(C[C@H]2OCCOC2(c2ccccc2)c2ccccc2)CC1 10.1016/j.ejmech.2019.02.056
CHEMBL4441888 176746 0 None -7 7 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 444 6 0 5 4.2 COc1ccccc1N1CCN(C[C@H]2OCCOC2(c2ccccc2)c2ccccc2)CC1 10.1016/j.ejmech.2019.02.056
118716711 121783 0 None -1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 389 4 0 6 1.6 COc1ccccc1N1CCN(CC2COC3(CCN(C(C)=O)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342864 121783 0 None -1 4 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 389 4 0 6 1.6 COc1ccccc1N1CCN(CC2COC3(CCN(C(C)=O)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
44275526 105642 0 None -12 3 Human 6.1 pKi = 6.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 621 11 2 6 7.3 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC(C)C)cc1 10.1021/jm960697s
CHEMBL27899 105642 0 None -12 3 Human 6.1 pKi = 6.1 Binding
Binding affinity was tested on human Alpha-1D adrenergic receptorBinding affinity was tested on human Alpha-1D adrenergic receptor
ChEMBL 621 11 2 6 7.3 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC(C)C)cc1 10.1021/jm960697s
10032383 116887 0 None -812 6 Human 6.1 pKi = 6.1 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
136680387 116887 0 None -812 6 Human 6.1 pKi = 6.1 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL323579 116887 0 None -812 6 Human 6.1 pKi = 6.1 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1 10.1016/s0960-894x(99)00484-9
44461012 111050 0 None -10 3 Human 6.1 pKi = 6.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 509 6 0 7 3.7 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3cc4c(cc32)CCCC4)CC1 10.1016/s0960-894x(98)00446-6
CHEMBL309949 111050 0 None -10 3 Human 6.1 pKi = 6.1 Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.Ability to displace beta ([125I]-iodo-4-hydroxyphenyl) ethylamino methyl tetralone from human cloned Alpha-1d adrenergic receptor stably expressed in HEK cells.
ChEMBL 509 6 0 7 3.7 O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3cc4c(cc32)CCCC4)CC1 10.1016/s0960-894x(98)00446-6
44273916 105605 0 None -1 3 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 608 7 2 8 3.4 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL278716 105605 0 None -1 3 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 608 7 2 8 3.4 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
9910451 170909 0 None -8 7 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 428 5 0 6 4.7 Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCC#N)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
CHEMBL420997 170909 0 None -8 7 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 428 5 0 6 4.7 Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCC#N)CC2)cn3-c2ccc(F)cc2)n1 10.1021/jm020938y
144096985 170873 0 None 4 3 Human 8.0 pKi = 8.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 385 9 1 4 3.5 CS(=O)(=O)c1ccccc1CCCNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
CHEMBL4209590 170873 0 None 4 3 Human 8.0 pKi = 8.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 385 9 1 4 3.5 CS(=O)(=O)c1ccccc1CCCNCCOc1cc(F)ccc1Cl 10.1016/j.ejmech.2017.07.071
10363912 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm021078o
CHEMBL1082862 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm021078o
CHEMBL286003 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assayAffinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm021078o
10363912 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL1082862 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
CHEMBL286003 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.ejmech.2019.05.024
10363912 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
CHEMBL1082862 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
CHEMBL286003 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1016/j.bmcl.2010.01.030
10363912 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm200421e
CHEMBL1082862 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm200421e
CHEMBL286003 13310 0 None -15 7 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 405 9 1 5 4.0 COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 10.1021/jm200421e
44431618 93841 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 488 8 1 7 3.3 COc1ccncc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
CHEMBL232607 93841 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity to human cloned adrenergic Alpha-1D receptorBinding affinity to human cloned adrenergic Alpha-1D receptor
ChEMBL 488 8 1 7 3.3 COc1ccncc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 10.1016/j.bmcl.2007.04.008
57929588 146752 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 373 4 2 5 1.8 CS(=O)(=O)c1ccc(Cn2cc(Cl)cc(C(N)=O)c2=N)cc1Cl 10.1021/acs.jmedchem.5b01528
CHEMBL3799869 146752 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysisDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D adrenergic receptor expressed in CHO-K1 cell membranes incubated for 60 mins by liquid scintillation counting analysis
ChEMBL 373 4 2 5 1.8 CS(=O)(=O)c1ccc(Cn2cc(Cl)cc(C(N)=O)c2=N)cc1Cl 10.1021/acs.jmedchem.5b01528
49781677 24645 0 None -9 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 400 2 0 3 5.7 Cc1cccc(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)c1 10.1021/jm100652h
CHEMBL1259063 24645 0 None -9 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
ChEMBL 400 2 0 3 5.7 Cc1cccc(-c2ccc3c(c2)C(N2CCN(C)CC2)Cc2ccccc2S3)c1 10.1021/jm100652h
145948065 174527 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1cccc2c1C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4217958 174527 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1cccc2c1C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
CHEMBL4302898 174527 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting methodDisplacement of 7-methoxy-[3H]-prazosin from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes after 60 mins by TopCount liquid scintillation counting method
ChEMBL 383 6 1 5 2.9 COc1cccc2c1C(NCCOc1cc(F)ccc1F)CCS2(=O)=O 10.1016/j.ejmech.2017.07.071
11465618 109175 23 None -35 19 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
CHEMBL3039528 109175 23 None -35 19 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
CHEMBL5191141 109175 23 None -35 19 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]prazosin from recombinant human alpha1D receptor measured after 60 mins by scintillation counting analysis
ChEMBL 354 2 0 2 4.9 CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C 10.1016/j.bmcl.2022.128879
118716719 121791 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 493 6 0 8 2.5 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4cccs4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
CHEMBL3342872 121791 0 None -1 4 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant alpha1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 493 6 0 8 2.5 COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4cccs4)CC3)O2)CC1 10.1016/j.ejmech.2014.09.070
10768829 126162 0 None -32 3 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 541 7 2 6 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
CHEMBL344525 126162 0 None -32 3 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 541 7 2 6 3.7 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990202+
2286 9957 51 None -8 30 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
4927 9957 51 None -8 30 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
7282 9957 51 None -8 30 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
CHEMBL643 9957 51 None -8 30 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
DB01069 9957 51 None -8 30 Human 7.1 pKi = 7.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C nan
10770007 41368 0 None -301 3 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 607 10 2 9 3.8 CCOC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
CHEMBL142957 41368 0 None -301 3 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 607 10 2 9 3.8 CCOC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 10.1021/jm990200p
11802456 177739 0 None -912 3 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 9 3 7 2.9 CCC1=C(C(=O)OC)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 10.1021/jm990202+
CHEMBL445577 177739 0 None -912 3 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 584 9 3 7 2.9 CCC1=C(C(=O)OC)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 10.1021/jm990202+
14925759 164817 6 None -31 13 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 349 5 0 3 3.2 O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 10.1021/acs.jmedchem.8b00265
CHEMBL4085780 164817 6 None -31 13 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting methodDisplacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillation counting method
ChEMBL 349 5 0 3 3.2 O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 10.1021/acs.jmedchem.8b00265
10627094 127869 0 None -575 3 Human 6.0 pKi = 6.0 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 581 10 0 7 5.8 COC(=O)C1=C(C)N=C(C)N(CCC[C@H](C)CN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
CHEMBL357131 127869 0 None -575 3 Human 6.0 pKi = 6.0 Binding
Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.Binding affinity against Alpha-1D adrenergic receptor (recombinant human receptor) using [3H]-prazosin.
ChEMBL 581 10 0 7 5.8 COC(=O)C1=C(C)N=C(C)N(CCC[C@H](C)CN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 10.1021/jm9902032
10816815 126133 0 None -2290 3 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 566 6 2 5 4.9 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CCCc4ccccc43)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
CHEMBL344339 126133 0 None -2290 3 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 566 6 2 5 4.9 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC3(CCCc4ccccc43)CC2)C1c1ccc(F)c(F)c1 10.1021/jm990201h
11058166 211484 0 None -2 5 Human 6.0 pKi = 6.0 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1 10.1021/jm000542r
CHEMBL74114 211484 0 None -2 5 Human 6.0 pKi = 6.0 Binding
Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranesAffinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
ChEMBL 271 4 2 5 0.6 CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1 10.1021/jm000542r
53328872 70177 0 None 3 3 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 433 5 0 5 2.9 COc1ccccc1N1CCN(CCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796048 70177 0 None 3 3 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 433 5 0 5 2.9 COc1ccccc1N1CCN(CCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
18738385 210503 0 None -181 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 427 7 0 5 4.4 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL67713 210503 0 None -181 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 427 7 0 5 4.4 CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)cs2)CC1 10.1016/s0960-894x(02)00347-5
1376848 210535 8 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 366 4 0 4 3.8 COc1ccccc1N1CCN(Cc2ccc(Br)s2)CC1 10.1016/s0960-894x(02)00347-5
CHEMBL67932 210535 8 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranesDisplacement of [125I]-HEAT from human Alpha-1D adrenergic receptor expressed in COS cells membranes
ChEMBL 366 4 0 4 3.8 COc1ccccc1N1CCN(Cc2ccc(Br)s2)CC1 10.1016/s0960-894x(02)00347-5
16041090 102168 0 None 1 4 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 10.1016/j.bmcl.2007.11.068
CHEMBL256853 102168 0 None 1 4 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 10.1016/j.bmcl.2007.11.068
16041630 104323 0 None -2 4 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
CHEMBL270589 104323 0 None -2 4 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human recombinant adrenergic alpha1C receptorDisplacement of [125I]HEAT from human recombinant adrenergic alpha1C receptor
ChEMBL 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 10.1016/j.bmcl.2007.11.068
71452768 86346 0 None -102 3 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assayTested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assay
ChEMBL 475 6 1 4 5.0 C[C@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1016/s0960-894x(00)00524-2
CHEMBL2114249 86346 0 None -102 3 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assayTested for binding affinity against recombinant human Alpha-1D adrenergic receptor using [125I]-HEAT in competition binding assay
ChEMBL 475 6 1 4 5.0 C[C@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 10.1016/s0960-894x(00)00524-2
240 7731 43 None -5 25 Human 7.0 pKi = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
2769 7731 43 None -5 25 Human 7.0 pKi = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
44279790 7731 43 None -5 25 Human 7.0 pKi = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
660 7731 43 None -5 25 Human 7.0 pKi = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
CHEMBL1729 7731 43 None -5 25 Human 7.0 pKi = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
CHEMBL560739 7731 43 None -5 25 Human 7.0 pKi = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
DB00604 7731 43 None -5 25 Human 7.0 pKi = 7.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N nan
10531476 41119 0 None -933 3 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 590 8 2 10 3.0 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc2nonc2c1 10.1021/jm990200p
CHEMBL142743 41119 0 None -933 3 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against Alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 590 8 2 10 3.0 COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc2nonc2c1 10.1021/jm990200p
56945166 78303 0 None -9 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 387 8 2 3 4.4 O[C@@H]1[C@@H](CNCCOc2ccccc2)CCC1(c1ccccc1)c1ccccc1 10.1021/jm200421e
CHEMBL1946785 78303 0 None -9 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 387 8 2 3 4.4 O[C@@H]1[C@@H](CNCCOc2ccccc2)CCC1(c1ccccc1)c1ccccc1 10.1021/jm200421e
CHEMBL1962872 78303 0 None -9 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 387 8 2 3 4.4 O[C@@H]1[C@@H](CNCCOc2ccccc2)CCC1(c1ccccc1)c1ccccc1 10.1021/jm200421e
10746137 43728 0 None -177 3 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 599 9 2 7 3.9 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C#N)(c3ccccc3F)CC2)C(=O)N1 10.1021/jm990201h
CHEMBL145134 43728 0 None -177 3 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.
ChEMBL 599 9 2 7 3.9 COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C#N)(c3ccccc3F)CC2)C(=O)N1 10.1021/jm990201h
2435 7509 100 None -28 12 Human 6.0 pKi = 6.0 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
395 7509 100 None -28 12 Human 6.0 pKi = 6.0 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
520 7509 100 None -28 12 Human 6.0 pKi = 6.0 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
5386 7509 100 None -28 12 Human 6.0 pKi = 6.0 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
CHEMBL844 7509 100 None -28 12 Human 6.0 pKi = 6.0 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
DB00484 7509 100 None -28 12 Human 6.0 pKi = 6.0 Binding
Binding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-1D adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
ChEMBL 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 10.1016/0960-894X(95)00391-6
10065903 29074 0 None -251 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 341 5 2 5 2.4 O[C@H]1[C@@H](NC[C@@H]2COc3ccccc3O2)CC[C@@H]1Oc1ccccc1 10.1021/jm991065j
CHEMBL132378 29074 0 None -251 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptorDisplacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor
ChEMBL 341 5 2 5 2.4 O[C@H]1[C@@H](NC[C@@H]2COc3ccccc3O2)CC[C@@H]1Oc1ccccc1 10.1021/jm991065j
44331169 174726 0 None -14 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 444 6 1 6 3.1 COc1ccccc1CCN1CCC2(CC1)CC(=O)c1ccc(NS(C)(=O)=O)cc1O2 10.1016/s0960-894x(98)00732-x
CHEMBL431631 174726 0 None -14 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 444 6 1 6 3.1 COc1ccccc1CCN1CCC2(CC1)CC(=O)c1ccc(NS(C)(=O)=O)cc1O2 10.1016/s0960-894x(98)00732-x
136680386 214482 0 None -199 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 680 16 4 8 4.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1 10.1016/s0960-894x(99)00484-9
44328801 214482 0 None -199 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 680 16 4 8 4.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1 10.1016/s0960-894x(99)00484-9
CHEMBL95578 214482 0 None -199 6 Human 6.0 pKi = 6.0 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
ChEMBL 680 16 4 8 4.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1 10.1016/s0960-894x(99)00484-9
44299945 108703 0 None -41 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.3 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCC(C#N)(c4ccccc4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL301024 108703 0 None -41 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.3 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCC(C#N)(c4ccccc4)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
155565219 183344 0 None -1 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 403 10 1 4 4.6 c1ccc(OCCNCC[C@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4580335 183344 0 None -1 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 403 10 1 4 4.6 c1ccc(OCCNCC[C@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
CHEMBL4597359 183344 0 None -1 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counterDisplacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
ChEMBL 403 10 1 4 4.6 c1ccc(OCCNCC[C@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 10.1016/j.ejmech.2019.05.024
155523275 177563 0 None -10 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@H]1OCCO[C@@H]1c1ccccc1 10.1016/j.ejmech.2019.02.056
CHEMBL4452933 177563 0 None -10 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assayDisplacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@H]1OCCO[C@@H]1c1ccccc1 10.1016/j.ejmech.2019.02.056
134157330 160483 0 None -31 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 321 7 1 5 2.7 COc1ccccc1OCCNCC1COC2(CCCCC2)O1 10.1016/j.ejmech.2016.09.050
CHEMBL3981480 160483 0 None -31 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting methodDisplacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method
ChEMBL 321 7 1 5 2.7 COc1ccccc1OCCNCC1COC2(CCCCC2)O1 10.1016/j.ejmech.2016.09.050
11995036 18616 0 None -2 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 419 7 1 5 4.5 COc1ccc2ccccc2c1OCCNC[C@@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL1182196 18616 0 None -2 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 419 7 1 5 4.5 COc1ccc2ccccc2c1OCCNC[C@@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
CHEMBL218732 18616 0 None -2 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cellsDisplacement of [3H]prazosin from cloned human adrenergic alpha 1D receptor expressed in CHO cells
ChEMBL 419 7 1 5 4.5 COc1ccc2ccccc2c1OCCNC[C@@H]1COc2cc3c(cc2O1)CCCC3 10.1021/jm060358r
489 6933 28 None -380 12 Rat 7.0 pKi = 7.0 Binding
Overall binding displacement in tissues containing only the Alpha-1B adrenergic receptor (rat spleen, rat liver)Overall binding displacement in tissues containing only the Alpha-1B adrenergic receptor (rat spleen, rat liver)
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
5640 6933 28 None -380 12 Rat 7.0 pKi = 7.0 Binding
Overall binding displacement in tissues containing only the Alpha-1B adrenergic receptor (rat spleen, rat liver)Overall binding displacement in tissues containing only the Alpha-1B adrenergic receptor (rat spleen, rat liver)
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
CHEMBL420060 6933 28 None -380 12 Rat 7.0 pKi = 7.0 Binding
Overall binding displacement in tissues containing only the Alpha-1B adrenergic receptor (rat spleen, rat liver)Overall binding displacement in tissues containing only the Alpha-1B adrenergic receptor (rat spleen, rat liver)
ChEMBL 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 10.1021/jm00018a001
44288485 169299 0 None -104 3 Human 6.0 pKi = 6.0 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 498 9 1 4 5.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C(c2ccc(C)cc2)c2ccc(C)cc2)CC1 10.1016/s0960-894x(00)00307-3
CHEMBL41677 169299 0 None -104 3 Human 6.0 pKi = 6.0 Binding
Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.Inhibition of binding of [125I]HEAT to cloned human alpha-1D adrenergic receptor.
ChEMBL 498 9 1 4 5.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C(c2ccc(C)cc2)c2ccc(C)cc2)CC1 10.1016/s0960-894x(00)00307-3
44300107 107463 0 None -162 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.5 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
CHEMBL292365 107463 0 None -162 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor stably expressed in HL cells
ChEMBL 607 7 2 7 4.5 COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 10.1016/s0960-894x(00)00374-7
53328686 70174 0 None -2 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 469 7 0 5 4.0 COc1ccc(Cl)cc1N1CCN(CCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
CHEMBL1796045 70174 0 None -2 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cellsDisplacement of [125I]BE-2254 from human adrenergic Alpha-1D receptor expressed in HEK293 cells
ChEMBL 469 7 0 5 4.0 COc1ccc(Cl)cc1N1CCN(CCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 10.1016/j.ejmech.2011.03.054
25130875 194406 0 None -2 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@@H]1CO[C@@H](c2ccccc2)CO1 10.1021/jm800461k
CHEMBL494908 194406 0 None -2 4 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cellsDisplacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells
ChEMBL 343 8 1 5 2.8 COc1ccccc1OCCNC[C@@H]1CO[C@@H](c2ccccc2)CO1 10.1021/jm800461k
11057 182928 23 None -2 20 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 182928 23 None -2 20 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 182928 23 None -2 20 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 182928 23 None -2 20 Human 6.0 pKi = 6.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
44288485 169299 0 None -104 3 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 498 9 1 4 5.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C(c2ccc(C)cc2)c2ccc(C)cc2)CC1 10.1016/s0960-894x(01)00320-1
CHEMBL41677 169299 0 None -104 3 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity towards cloned human Alpha-1D adrenergic receptorIn vitro binding affinity towards cloned human Alpha-1D adrenergic receptor
ChEMBL 498 9 1 4 5.1 COC(=O)C1(c2ccccc2)CCN(CCCNC(=O)C(c2ccc(C)cc2)c2ccc(C)cc2)CC1 10.1016/s0960-894x(01)00320-1
9879119 16218 0 None -43 5 Rat 6.0 pKi = 6.0 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 291 4 2 3 2.2 CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
CHEMBL111771 16218 0 None -43 5 Rat 6.0 pKi = 6.0 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
ChEMBL 291 4 2 3 2.2 CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1 10.1007/s00044-004-0020-z
9879119 16218 0 None -43 5 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 291 4 2 3 2.2 CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1 10.1021/jm030551a
CHEMBL111771 16218 0 None -43 5 Rat 6.0 pKi = 6.0 Binding
In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assayIn vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay
ChEMBL 291 4 2 3 2.2 CCS(=O)(=O)Nc1cccc2c1CCC2c1c[nH]cn1 10.1021/jm030551a
53248361 68856 0 None -63 7 Human 7.0 pKi = 7.0 Binding
Inhibition of adrenergic Alpha-1D receptorInhibition of adrenergic Alpha-1D receptor
ChEMBL 568 7 0 5 3.2 COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 10.1021/jm1009956
CHEMBL1774991 68856 0 None -63 7 Human 7.0 pKi = 7.0 Binding
Inhibition of adrenergic Alpha-1D receptorInhibition of adrenergic Alpha-1D receptor
ChEMBL 568 7 0 5 3.2 COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 10.1021/jm1009956
44331198 11231 0 None -1 3 Human 7.0 pKi = 7 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 357 3 0 2 5.2 c1ccc2c(c1)CCC1(CCN(CCc3cccc4ccccc34)CC1)O2 10.1016/s0960-894x(98)00732-x
CHEMBL101739 11231 0 None -1 3 Human 7.0 pKi = 7 Binding
Displacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cellsDisplacement of [125I]HEAT from human Alpha-1D adrenergic receptor expressed in HEK cells
ChEMBL 357 3 0 2 5.2 c1ccc2c(c1)CCC1(CCN(CCc3cccc4ccccc34)CC1)O2 10.1016/s0960-894x(98)00732-x
60820 11080 14 UNDEFINED -1 12 Human 10.7 pKi = 10.7 Binding
NoneNone
PDSP KiDatabase 421 6 0 4 4.4 CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1 None
CHEMBL10085 11080 14 UNDEFINED -1 12 Human 10.7 pKi = 10.7 Binding
NoneNone
PDSP KiDatabase 421 6 0 4 4.4 CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1 None
129211 10521 78 3H-PRAZOSIN -1 16 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
2562 10521 78 3H-PRAZOSIN -1 16 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
488 10521 78 3H-PRAZOSIN -1 16 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
CHEMBL836 10521 78 3H-PRAZOSIN -1 16 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
DB00706 10521 78 3H-PRAZOSIN -1 16 Human 10.5 pKi = 10.5 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
4209 9937 75 3H-PRAZOSIN 1 33 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 3H-PRAZOSIN 1 33 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 3H-PRAZOSIN 1 33 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 3H-PRAZOSIN 1 33 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 3H-PRAZOSIN 1 33 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 3H-PRAZOSIN 1 33 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
129211 10521 78 3H-PRAZOSIN -1 16 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
2562 10521 78 3H-PRAZOSIN -1 16 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
488 10521 78 3H-PRAZOSIN -1 16 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
CHEMBL836 10521 78 3H-PRAZOSIN -1 16 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
DB00706 10521 78 3H-PRAZOSIN -1 16 Human 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
None 223346 0 UNDEFINED 2 6 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 222737 0 UNDEFINED 4 19 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 421 9 1 6 4.3 COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4 None
None 223021 0 3H-PRAZOSIN 66 2 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 555 7 1 9 4.3 COC1=CC=CC2=C1C3CN(CC3CO2)CCCCN4C(=O)C5=C(C6=NC(=CN=C6S5)C7=CC=CC=C7)NC4=O None
129211 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
2562 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
488 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
CHEMBL836 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
DB00706 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
4209 9937 75 UNDEFINED 1 33 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 UNDEFINED 1 33 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 UNDEFINED 1 33 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 UNDEFINED 1 33 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 UNDEFINED 1 33 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 UNDEFINED 1 33 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
129211 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
2562 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
488 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
CHEMBL836 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
DB00706 10521 78 UNDEFINED -1 16 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
2726 7706 68 125I-HEAT 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
2726 7706 68 3H-PRAZOSIN 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 125I-HEAT 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 3H-PRAZOSIN 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 125I-HEAT 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 3H-PRAZOSIN 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 125I-HEAT 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 3H-PRAZOSIN 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 125I-HEAT 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 3H-PRAZOSIN 1 72 Human 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
4209 9937 75 125I-HEAT -2 33 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 125I-HEAT -2 33 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 125I-HEAT -2 33 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 125I-HEAT -2 33 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 125I-HEAT -2 33 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 125I-HEAT -2 33 Rat 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4209 9937 75 125I-BE2254 1 33 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 125I-BE2254 1 33 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 125I-BE2254 1 33 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 125I-BE2254 1 33 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 125I-BE2254 1 33 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 125I-BE2254 1 33 Human 9.4 pKi = 9.4 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
None 223346 0 UNDEFINED 2 6 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
489 6933 28 UNDEFINED -34 12 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C None
5640 6933 28 UNDEFINED -34 12 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C None
CHEMBL420060 6933 28 UNDEFINED -34 12 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C None
None 223346 0 UNDEFINED 2 6 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
3584 10549 64 3H-PRAZOSIN -1 14 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
5401 10549 64 3H-PRAZOSIN -1 14 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
7302 10549 64 3H-PRAZOSIN -1 14 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
CHEMBL611 10549 64 3H-PRAZOSIN -1 14 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
DB01162 10549 64 3H-PRAZOSIN -1 14 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
4209 9937 75 125I-BE2254 1 33 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 125I-BE2254 1 33 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 125I-BE2254 1 33 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 125I-BE2254 1 33 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 125I-BE2254 1 33 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 125I-BE2254 1 33 Human 9.2 pKi = 9.2 Binding
NoneNone
PDSP KiDatabase 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
None 223346 0 UNDEFINED 2 6 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223021 0 3H-PRAZOSIN 66 2 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 555 7 1 9 4.3 COC1=CC=CC2=C1C3CN(CC3CO2)CCCCN4C(=O)C5=C(C6=NC(=CN=C6S5)C7=CC=CC=C7)NC4=O None
None 223346 0 UNDEFINED 2 6 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 9.0 pKi = 9 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
31101 7516 40 3H-PRAZOSIN -7 35 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 3H-PRAZOSIN -7 35 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 3H-PRAZOSIN -7 35 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 3H-PRAZOSIN -7 35 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 3H-PRAZOSIN -7 35 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
16041629 102221 0 UNDEFINED -1 4 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 None
CHEMBL257097 102221 0 UNDEFINED -1 4 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 None
None 223405 0 UNDEFINED 11 4 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 359 1 2 3 5.3 CC1=CC=CC=C1N2C3=CC=CC=C3C(CC(C4=CC=CC=C42)(C)O)(C)O None
100 10577 58 125I-HEAT -1 54 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 125I-HEAT -1 54 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 125I-HEAT -1 54 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 125I-HEAT -1 54 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 125I-HEAT -1 54 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
None 223346 0 UNDEFINED 2 6 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
219050 10146 25 3H-PRAZOSIN -11 21 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
52 10146 25 3H-PRAZOSIN -11 21 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
CHEMBL431367 10146 25 3H-PRAZOSIN -11 21 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
None 223346 0 UNDEFINED 2 6 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
16041264 102218 0 UNDEFINED 1 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 None
CHEMBL257077 102218 0 UNDEFINED 1 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
135398737 7745 93 125I-HEAT -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
135398737 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 125I-HEAT -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 125I-HEAT -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 125I-HEAT -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 125I-HEAT -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
16041092 102155 0 UNDEFINED 1 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 None
CHEMBL256804 102155 0 UNDEFINED 1 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
135398737 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-PRAZOSIN -2 90 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
16041629 102221 0 UNDEFINED -1 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 None
CHEMBL257097 102221 0 UNDEFINED -1 4 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 None
2435 10362 83 3H-PRAZOSIN -3 48 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-PRAZOSIN -3 48 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-PRAZOSIN -3 48 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-PRAZOSIN -3 48 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-PRAZOSIN -3 48 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
None 223346 0 UNDEFINED 2 6 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
3584 10549 64 3H-PRAZOSIN -1 14 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
5401 10549 64 3H-PRAZOSIN -1 14 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
7302 10549 64 3H-PRAZOSIN -1 14 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
CHEMBL611 10549 64 3H-PRAZOSIN -1 14 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
DB01162 10549 64 3H-PRAZOSIN -1 14 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
115 7131 71 UNDEFINED -1 7 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
2092 7131 71 UNDEFINED -1 7 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
7109 7131 71 UNDEFINED -1 7 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
CHEMBL709 7131 71 UNDEFINED -1 7 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
DB00346 7131 71 UNDEFINED -1 7 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
209 9831 97 3H-PRAZOSIN -14 23 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
2113 9831 97 3H-PRAZOSIN -14 23 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4748 9831 97 3H-PRAZOSIN -14 23 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL567 9831 97 3H-PRAZOSIN -14 23 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00850 9831 97 3H-PRAZOSIN -14 23 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 403 6 1 5 3.9 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
None 223346 0 UNDEFINED 2 6 Human 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
129211 10521 78 None -1 16 Rat 8.0 pKi = 8.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
2562 10521 78 None -1 16 Rat 8.0 pKi = 8.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
488 10521 78 None -1 16 Rat 8.0 pKi = 8.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
CHEMBL836 10521 78 None -1 16 Rat 8.0 pKi = 8.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
DB00706 10521 78 None -1 16 Rat 8.0 pKi = 8.0 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
129211 10521 78 None -1 16 Human 8.0 pKi = 8.0 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
2562 10521 78 None -1 16 Human 8.0 pKi = 8.0 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
488 10521 78 None -1 16 Human 8.0 pKi = 8.0 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
CHEMBL836 10521 78 None -1 16 Human 8.0 pKi = 8.0 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
DB00706 10521 78 None -1 16 Human 8.0 pKi = 8.0 Binding
Binding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligandBinding affinity against human adrenergic receptor subtype Alpha-1D adrenergic receptor using [3H]prazosin as radioligand
Drug Central 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C None
521 8186 69 None 2 7 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
5311068 8186 69 None 2 7 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
835 8186 69 None 2 7 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
CHEMBL778 8186 69 None 2 7 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
DB00633 8186 69 None 2 7 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat
Drug Central 200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C None
2803 7742 58 3H-PRAZOSIN -2 19 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 3H-PRAZOSIN -2 19 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 3H-PRAZOSIN -2 19 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 3H-PRAZOSIN -2 19 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 3H-PRAZOSIN -2 19 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
484 9633 51 125I-HEAT 4 35 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 9633 51 125I-HEAT 4 35 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 9633 51 125I-HEAT 4 35 Rat 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
None 223346 0 UNDEFINED 2 6 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
202 8290 77 3H-PRAZOSIN -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
202 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 3H-PRAZOSIN -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 3H-PRAZOSIN -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 3H-PRAZOSIN -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 3H-PRAZOSIN -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
43815 193699 64 3H-PRAZOSIN -199 25 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL1708 193699 64 3H-PRAZOSIN -199 25 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL490 193699 64 3H-PRAZOSIN -199 25 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
5656 209845 87 3H-PRAZOSIN -25 43 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
5656 209845 87 UNDEFINED -7 43 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 3H-PRAZOSIN -25 43 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 UNDEFINED -7 43 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 209906 52 UNDEFINED -1 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 209906 52 UNDEFINED -1 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 224111 0 3H-PRAZOSIN -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
179 7188 115 125I-HEAT -4365 50 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2159 7188 115 125I-HEAT -4365 50 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
963 7188 115 125I-HEAT -4365 50 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
CHEMBL243712 7188 115 125I-HEAT -4365 50 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
DB06288 7188 115 125I-HEAT -4365 50 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
1753 9282 28 125I-HEAT 1 5 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
483 9282 28 125I-HEAT 1 5 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
6082 9282 28 125I-HEAT 1 5 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
CHEMBL524 9282 28 125I-HEAT 1 5 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
DB00723 9282 28 125I-HEAT 1 5 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
134 9292 24 125I-HEAT -8511 67 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
1775 9292 24 125I-HEAT -8511 67 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
9681 9292 24 125I-HEAT -8511 67 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
CHEMBL1065 9292 24 125I-HEAT -8511 67 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
DB00247 9292 24 125I-HEAT -8511 67 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 353 4 2 4 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO None
484 9633 51 125I-BE2254 -93 35 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 9633 51 125I-BE2254 -93 35 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 9633 51 125I-BE2254 -93 35 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
15897 9637 0 125I-HEAT -275 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
215 9637 0 125I-HEAT -275 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
CHEMBL1979333 9637 0 125I-HEAT -275 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
4508 9913 98 125I-HEAT -1995 13 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
4866774 9913 98 125I-HEAT -1995 13 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
509 9913 98 125I-HEAT -1995 13 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
838 9913 98 125I-HEAT -1995 13 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
CHEMBL1740 9913 98 125I-HEAT -1995 13 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
119570 9933 96 3H-PRAZOSIN -4570 39 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
2233 9933 96 3H-PRAZOSIN -4570 39 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
953 9933 96 3H-PRAZOSIN -4570 39 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
CHEMBL301265 9933 96 3H-PRAZOSIN -4570 39 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
DB00413 9933 96 3H-PRAZOSIN -4570 39 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 211 3 2 4 1.6 CCCN[C@H]1CCc2c(C1)sc(n2)N None
2 10035 23 3H-PRAZOSIN -2089 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 219 2 1 2 2.0 CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 None
54562 10035 23 3H-PRAZOSIN -2089 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 219 2 1 2 2.0 CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 None
CHEMBL240773 10035 23 3H-PRAZOSIN -2089 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 219 2 1 2 2.0 CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2 None
2402 10143 62 3H-PRAZOSIN -549 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
5095 10143 62 3H-PRAZOSIN -549 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
7295 10143 62 3H-PRAZOSIN -549 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
CHEMBL589 10143 62 3H-PRAZOSIN -549 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
DB00268 10143 62 3H-PRAZOSIN -549 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 260 7 1 2 3.5 CCCN(CCC)CCc1cccc2c1CC(=N2)O None
128563 10237 33 125I-HEAT -2398 42 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
1666 10237 33 125I-HEAT -2398 42 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
CHEMBL445332 10237 33 125I-HEAT -2398 42 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
DB12327 10237 33 125I-HEAT -2398 42 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 3 0 8 3.0 COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1 None
6917970 10463 61 3H-PRAZOSIN -2290 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
8370 10463 61 3H-PRAZOSIN -2290 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
CHEMBL487387 10463 61 3H-PRAZOSIN -2290 33 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 327 2 2 5 2.8 COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O None
2662 18156 131 3H-PRAZOSIN -41 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
CHEMBL118 18156 131 3H-PRAZOSIN -41 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 381 3 1 4 3.5 Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 None
5090 22333 106 3H-PRAZOSIN -1348 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 None
CHEMBL122 22333 106 3H-PRAZOSIN -1348 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 0 4 2.6 CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 None
10297 33885 30 125I-HEAT -38 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 None
CHEMBL136560 33885 30 125I-HEAT -38 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 C[C@H](N)[C@H](O)c1ccccc1 None
127151 42104 18 3H-PRAZOSIN -1584 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 313 6 1 4 3.2 CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 None
3022645 42104 18 3H-PRAZOSIN -1584 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 313 6 1 4 3.2 CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 None
CHEMBL14370 42104 18 3H-PRAZOSIN -1584 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 313 6 1 4 3.2 CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 None
156391 53574 99 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
CHEMBL1200806 53574 99 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
CHEMBL154 53574 99 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 None
10624 77075 19 125I-HEAT -776 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
138543650 77075 19 125I-HEAT -776 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
CHEMBL194378 77075 19 125I-HEAT -776 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 None
2244 101008 100 3H-PRAZOSIN -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 180 2 1 3 1.3 CC(=O)Oc1ccccc1C(=O)O None
CHEMBL25 101008 100 3H-PRAZOSIN -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 180 2 1 3 1.3 CC(=O)Oc1ccccc1C(=O)O None
104870 105656 47 3H-PRAZOSIN -22 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
5374 105656 47 3H-PRAZOSIN -22 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
CHEMBL279085 105656 47 3H-PRAZOSIN -22 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
3663 106743 83 3H-PRAZOSIN -288 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 504 0 6 8 5.1 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 None
CHEMBL286494 106743 83 3H-PRAZOSIN -288 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 504 0 6 8 5.1 Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65 None
1615 174570 24 125I-HEAT -26 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 193 3 1 3 1.6 CNC(C)Cc1ccc2c(c1)OCO2 None
CHEMBL43048 174570 24 125I-HEAT -26 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 193 3 1 3 1.6 CNC(C)Cc1ccc2c(c1)OCO2 None
5280343 195054 124 3H-PRAZOSIN -147 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
CHEMBL1520590 195054 124 3H-PRAZOSIN -147 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
CHEMBL50 195054 124 3H-PRAZOSIN -147 31 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 302 1 5 7 2.0 O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 None
3672 199312 136 3H-PRAZOSIN -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 206 4 1 1 3.1 CC(C)Cc1ccc(C(C)C(=O)O)cc1 None
CHEMBL521 199312 136 3H-PRAZOSIN -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 206 4 1 1 3.1 CC(C)Cc1ccc(C(C)C(=O)O)cc1 None
54676228 200394 112 3H-PRAZOSIN -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 331 2 2 5 1.6 CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O None
CHEMBL527 200394 112 3H-PRAZOSIN -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 331 2 2 5 1.6 CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O None
2771 201796 74 3H-PRAZOSIN -9 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL1200781 201796 74 3H-PRAZOSIN -9 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL549 201796 74 3H-PRAZOSIN -9 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
4495 203314 92 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 None
CHEMBL56367 203314 92 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 308 5 1 5 2.8 CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 None
54677470 207330 115 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
CHEMBL1256873 207330 115 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
CHEMBL599 207330 115 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 None
162265 209053 22 125I-HEAT -239 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 125I-HEAT -239 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 125I-HEAT -239 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
5281600 209804 92 3H-PRAZOSIN -275 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 538 3 6 10 5.1 O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 None
CHEMBL63354 209804 92 3H-PRAZOSIN -275 32 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 538 3 6 10 5.1 O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12 None
5656 209845 87 3H-PRAZOSIN -25 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 3H-PRAZOSIN -25 43 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
202478 211466 20 125I-HEAT -52 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 219 3 1 2 3.0 CCCN1CCC[C@H](c2cccc(O)c2)C1 None
CHEMBL7393 211466 20 125I-HEAT -52 25 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 219 3 1 2 3.0 CCCN1CCC[C@H](c2cccc(O)c2)C1 None
5311189 211620 11 125I-HEAT -112 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 219 3 1 2 3.0 CCCN1CCC[C@@H](c2cccc(O)c2)C1 None
CHEMBL7549 211620 11 125I-HEAT -112 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 219 3 1 2 3.0 CCCN1CCC[C@@H](c2cccc(O)c2)C1 None
4158 212120 21 125I-HEAT -141 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
CHEMBL1722 212120 21 125I-HEAT -141 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
CHEMBL796 212120 21 125I-HEAT -141 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 233 3 1 3 2.1 COC(=O)C(c1ccccc1)C1CCCCN1 None
4054 212280 72 125I-HEAT -1 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
CHEMBL1699 212280 72 125I-HEAT -1 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
CHEMBL807 212280 72 125I-HEAT -1 36 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 179 0 1 1 2.7 CC12CC3CC(C)(C1)CC(N)(C3)C2 None
119607 212982 113 3H-PRAZOSIN -97 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 None
CHEMBL865 212982 113 3H-PRAZOSIN -97 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 314 3 1 4 3.0 Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 None
3337 213146 27 125I-HEAT -245 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 125I-HEAT -245 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 125I-HEAT -245 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 125I-HEAT -245 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 125I-HEAT -245 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
11954224 222732 0 125I-HEAT -4073 59 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
None 222772 0 3H-PRAZOSIN -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 329 2 0 4 3.6 CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl None
25137849 222958 0 125I-HEAT -4 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
71290 222958 0 125I-HEAT -4 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 165 3 2 2 1.3 CC(C(C1=CC=CC=C1)O)NC None
None 223090 0 125I-HEAT -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 240 7 4 6 -0.8 C(C(C(=O)O)N)SSCC(C(=O)O)N None
None 223091 0 125I-HEAT -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 149 4 2 3 0.2 CSCCC(C(=O)O)N None
None 223092 0 125I-HEAT -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 135 3 3 3 -0.3 C(CS)C(C(=O)O)N None
None 223093 0 125I-HEAT -1 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 121 2 3 3 -0.7 C(C(C(=O)O)N)S None
None 223094 0 125I-HEAT -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 117 0 1 3 -0.0 C1CSC(=O)C1N None
None 223095 0 125I-HEAT -1 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 153 3 3 3 -1.4 C(C(C(=O)O)N)S(=O)O None
None 223096 0 125I-HEAT -1 39 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 169 3 3 4 -1.7 C(C(C(=O)O)N)S(=O)(=O)O None
None 223097 0 125I-HEAT -1 30 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 183 4 3 4 -1.3 C(CS(=O)(=O)O)C(C(=O)O)N None
None 223104 0 125I-HEAT -13 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 149 2 1 2 1.2 CC(C(=O)C1=CC=CC=C1)N None
1576 223105 0 125I-HEAT -16 40 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 163 3 1 2 1.5 CC(C(=O)C1=CC=CC=C1)NC None
None 223106 0 3H-PRAZOSIN -16 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 536 11 1 4 9.0 CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C None
4978 223107 0 3H-PRAZOSIN -7 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 520 1 7 9 4.3 CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O None
None 223108 0 3H-PRAZOSIN -3 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 464 4 8 12 -0.6 C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O None
None 223109 0 3H-PRAZOSIN -281 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 610 6 10 16 -1.7 CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O None
None 223110 0 3H-PRAZOSIN -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 448 3 7 11 0.4 CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O None
None 223121 0 3H-PRAZOSIN -1862 19 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 246 2 1 4 1.6 CCCN1CCCC2C1CC3=CN=C(N=C3C2)N None
135269 223168 0 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 222 5 1 3 2.5 CCCCC(=O)OC1=CC=CC=C1C(=O)O None
23681059 223169 0 3H-PRAZOSIN -1 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 230 3 1 2 3.0 CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O None
5018304 223170 0 3H-PRAZOSIN -1 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 317 4 1 3 0.0 C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+] None
84003 223171 0 3H-PRAZOSIN -1 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 376 6 5 7 -0.0 C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O None
123619 223172 0 3H-PRAZOSIN -1412 27 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 358 3 0 4 4.2 CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl None
119828 223173 0 3H-PRAZOSIN -1 29 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 370 5 1 5 3.5 CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C None
None 223174 0 3H-PRAZOSIN -7 28 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 517 8 2 5 5.2 CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C None
None 223268 0 3H-PRAZOSIN -4570 26 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 347 6 0 3 5.0 CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3 None
16041451 104584 0 UNDEFINED -1 4 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
CHEMBL271913 104584 0 UNDEFINED -1 4 Human 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
135409468 8816 69 3H-PRAZOSIN -37 39 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
333 8816 69 3H-PRAZOSIN -37 39 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
CHEMBL845 8816 69 3H-PRAZOSIN -37 39 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 2 4 1.7 Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1 None
2105 9828 37 3H-PRAZOSIN -72 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 3H-PRAZOSIN -72 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 3H-PRAZOSIN -72 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 3H-PRAZOSIN -72 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 3H-PRAZOSIN -72 32 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
135398745 9688 112 125I-HEAT -24 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 125I-HEAT -24 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 125I-HEAT -24 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 125I-HEAT -24 65 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
16041091 101996 0 UNDEFINED -1 4 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 None
CHEMBL256041 101996 0 UNDEFINED -1 4 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 None
16041263 102222 0 UNDEFINED 1 4 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 None
CHEMBL257098 102222 0 UNDEFINED 1 4 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 None
11954259 222758 0 3H-PRAZOSIN -38 43 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 443 5 0 5 3.5 CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C None
None 223346 0 UNDEFINED 2 6 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
16041090 102168 0 UNDEFINED 1 4 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 None
CHEMBL256853 102168 0 UNDEFINED 1 4 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 None
2142 9870 58 125I-HEAT -12 37 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
4920903 9870 58 125I-HEAT -12 37 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
502 9870 58 125I-HEAT -12 37 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
5775 9870 58 125I-HEAT -12 37 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
CHEMBL597 9870 58 125I-HEAT -12 37 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
DB00692 9870 58 125I-HEAT -12 37 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
None 223346 0 UNDEFINED 2 6 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
135398745 9688 112 3H-PRAZOSIN -24 65 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-PRAZOSIN -24 65 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-PRAZOSIN -24 65 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-PRAZOSIN -24 65 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
185 10778 60 3H-PRAZOSIN -1230 37 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
5311271 10778 60 3H-PRAZOSIN -1230 37 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
CHEMBL74355 10778 60 3H-PRAZOSIN -1230 37 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
DB16351 10778 60 3H-PRAZOSIN -1230 37 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
1353 8692 93 125I-HEAT -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1353 8692 93 3H-PRAZOSIN -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 125I-HEAT -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-PRAZOSIN -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 125I-HEAT -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-PRAZOSIN -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 125I-HEAT -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-PRAZOSIN -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 125I-HEAT -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-PRAZOSIN -10 85 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
11954259 222758 0 125I-HEAT -38 43 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 443 5 0 5 3.5 CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C None
None 223346 0 UNDEFINED 2 6 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2803 7742 58 3H-PRAZOSIN -12 19 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 3H-PRAZOSIN -12 19 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 3H-PRAZOSIN -12 19 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 3H-PRAZOSIN -12 19 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 3H-PRAZOSIN -12 19 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
41 8440 0 3H-PRAZOSIN -199 17 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 195 0 1 3 0.9 Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 None
72036 8440 0 3H-PRAZOSIN -199 17 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 195 0 1 3 0.9 Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 None
CHEMBL1765294 8440 0 3H-PRAZOSIN -199 17 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 195 0 1 3 0.9 Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 None
104870 105656 47 3H-PRAZOSIN -22 21 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
5374 105656 47 3H-PRAZOSIN -22 21 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
CHEMBL279085 105656 47 3H-PRAZOSIN -22 21 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
185 10778 60 125I-HEAT -1230 37 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
5311271 10778 60 125I-HEAT -1230 37 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
CHEMBL74355 10778 60 125I-HEAT -1230 37 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
DB16351 10778 60 125I-HEAT -1230 37 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 373 7 1 4 3.8 COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O None
None 223346 0 UNDEFINED 2 6 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
7153 104796 77 3H-PRAZOSIN -72 33 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
CHEMBL272942 104796 77 3H-PRAZOSIN -72 33 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 214 3 1 2 2.5 Cc1cc(Cl)ccc1OC(C)C(=O)O None
16041628 162129 0 UNDEFINED -1 4 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 None
CHEMBL403280 162129 0 UNDEFINED -1 4 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.9 pKi = 7.9 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
6102 222821 0 125I-HEAT 6 4 Rat 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 167 3 3 3 0.6 CNCC(C1=CC(=CC=C1)O)O None
16041091 101996 0 UNDEFINED -1 4 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 None
CHEMBL256041 101996 0 UNDEFINED -1 4 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
213 10625 55 125I-HEAT -4 43 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
2717 10625 55 125I-HEAT -4 43 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
5533 10625 55 125I-HEAT -4 43 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
CHEMBL621 10625 55 125I-HEAT -4 43 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
DB00656 10625 55 125I-HEAT -4 43 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
16040907 104659 0 UNDEFINED 2 4 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
CHEMBL272340 104659 0 UNDEFINED 2 4 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
102 10899 48 3H-PRAZOSIN -363 49 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-PRAZOSIN -363 49 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-PRAZOSIN -363 49 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-PRAZOSIN -363 49 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-PRAZOSIN -363 49 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
16041265 102112 0 UNDEFINED 1 4 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 None
CHEMBL256597 102112 0 UNDEFINED 1 4 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
444 213445 53 3H-PRAZOSIN -3311 18 Human 4.8 pKi = 4.8 Binding
NoneNone
PDSP KiDatabase 239 3 1 2 3.3 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 None
CHEMBL894 213445 53 3H-PRAZOSIN -3311 18 Human 4.8 pKi = 4.8 Binding
NoneNone
PDSP KiDatabase 239 3 1 2 3.3 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 None
None 223120 0 3H-PRAZOSIN -288 19 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 451 8 2 4 3.2 CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C None
None 223346 0 UNDEFINED 2 6 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2865 10915 73 125I-HEAT -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
2865 10915 73 3H-PRAZOSIN -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 125I-HEAT -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-PRAZOSIN -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 125I-HEAT -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-PRAZOSIN -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 125I-HEAT -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-PRAZOSIN -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 125I-HEAT -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-PRAZOSIN -37 53 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
None 223346 0 UNDEFINED 2 6 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
104911 222798 0 3H-PRAZOSIN -50 37 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 530 7 0 5 5.1 COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl None
186 8588 52 125I-HEAT -309 17 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 295 5 1 2 3.7 OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 None
71781 8588 52 125I-HEAT -309 17 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 295 5 1 2 3.7 OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 None
CHEMBL18972 8588 52 125I-HEAT -309 17 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 295 5 1 2 3.7 OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1 None
None 223346 0 UNDEFINED 2 6 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
135398737 7745 93 UNDEFINED -2 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 UNDEFINED -2 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 UNDEFINED -2 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 UNDEFINED -2 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 UNDEFINED -2 90 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
None 223346 0 UNDEFINED 2 6 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
104911 222798 0 3H-PRAZOSIN -50 37 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 530 7 0 5 5.1 COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl None
16362 9899 71 3H-PRAZOSIN -1047 29 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
2172 9899 71 3H-PRAZOSIN -1047 29 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
90 9899 71 3H-PRAZOSIN -1047 29 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
CHEMBL1423 9899 71 3H-PRAZOSIN -1047 29 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
DB01100 9899 71 3H-PRAZOSIN -1047 29 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 None
183782 10171 20 3H-PRAZOSIN -47 14 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 352 8 1 4 4.4 CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N None
237 10171 20 3H-PRAZOSIN -47 14 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 352 8 1 4 4.4 CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL85251 10171 20 3H-PRAZOSIN -47 14 Rat 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 352 8 1 4 4.4 CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N None
102 10899 48 3H-PRAZOSIN -363 49 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 3H-PRAZOSIN -363 49 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 3H-PRAZOSIN -363 49 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 3H-PRAZOSIN -363 49 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 3H-PRAZOSIN -363 49 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
68602 211905 80 3H-PRAZOSIN -37 8 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
CHEMBL77921 211905 80 3H-PRAZOSIN -37 8 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
25058166 222739 0 3H-PRAZOSIN -177 26 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
6852389 222739 0 3H-PRAZOSIN -177 26 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
None 223346 0 UNDEFINED 2 6 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 222737 0 125I-HEAT -13 19 Rat 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 421 9 1 6 4.3 COC1=C(C(=CC=C1)OC)OCCNCC2C(OC3=CC=CC=C3O2)C4=CC=CC=C4 None
None 223346 0 UNDEFINED 2 6 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
115237 62359 119 3H-PRAZOSIN -10 54 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 62359 119 3H-PRAZOSIN -10 54 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
None 223346 0 UNDEFINED 2 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
219050 10146 25 3H-PRAZOSIN -11 21 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
52 10146 25 3H-PRAZOSIN -11 21 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
CHEMBL431367 10146 25 3H-PRAZOSIN -11 21 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 346 6 2 2 5.0 Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2 None
16041265 102112 0 UNDEFINED 1 4 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 None
CHEMBL256597 102112 0 UNDEFINED 1 4 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
16041451 104584 0 UNDEFINED -1 4 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
CHEMBL271913 104584 0 UNDEFINED -1 4 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
16041628 162129 0 UNDEFINED -1 4 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 None
CHEMBL403280 162129 0 UNDEFINED -1 4 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1588 9105 27 3H-PRAZOSIN -20 44 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 3H-PRAZOSIN -20 44 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 3H-PRAZOSIN -20 44 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 3H-PRAZOSIN -20 44 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 3H-PRAZOSIN -20 44 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
16041090 102168 0 UNDEFINED 1 4 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 None
CHEMBL256853 102168 0 UNDEFINED 1 4 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 None
None 223346 0 UNDEFINED 2 6 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2470 10425 50 3H-PRAZOSIN -309 58 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-PRAZOSIN -309 58 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-PRAZOSIN -309 58 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-PRAZOSIN -309 58 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-PRAZOSIN -309 58 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
1209 8439 75 3H-PRAZOSIN -371 32 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
203 8439 75 3H-PRAZOSIN -371 32 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
3386 8439 75 3H-PRAZOSIN -371 32 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
CHEMBL41 8439 75 3H-PRAZOSIN -371 32 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
DB00472 8439 75 3H-PRAZOSIN -371 32 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F None
446220 140299 14 125I-HEAT -371 45 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 303 3 0 5 1.9 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C None
CHEMBL370805 140299 14 125I-HEAT -371 45 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 303 3 0 5 1.9 COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C None
None 223346 0 UNDEFINED 2 6 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
124 9755 47 125I-HEAT -338 32 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 125I-HEAT -338 32 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 125I-HEAT -338 32 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 125I-HEAT -338 32 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 125I-HEAT -338 32 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2202 9906 96 3H-PRAZOSIN -3 21 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
4850 9906 96 3H-PRAZOSIN -3 21 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
49 9906 96 3H-PRAZOSIN -3 21 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
CHEMBL1371770 9906 96 3H-PRAZOSIN -3 21 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
DB12478 9906 96 3H-PRAZOSIN -3 21 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
2337 10030 77 125I-HEAT -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2337 10030 77 3H-PRAZOSIN -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 125I-HEAT -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-PRAZOSIN -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 125I-HEAT -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-PRAZOSIN -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 125I-HEAT -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-PRAZOSIN -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 125I-HEAT -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-PRAZOSIN -2 62 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
16041264 102218 0 UNDEFINED 1 4 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 None
CHEMBL257077 102218 0 UNDEFINED 1 4 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2995 211184 53 3H-PRAZOSIN -3 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
CHEMBL1696 211184 53 3H-PRAZOSIN -3 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
CHEMBL72 211184 53 3H-PRAZOSIN -3 23 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 266 4 1 2 3.5 CNCCCN1c2ccccc2CCc2ccccc21 None
None 223346 0 UNDEFINED 2 6 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
214 10632 58 3H-PRAZOSIN -28 30 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
2740 10632 58 3H-PRAZOSIN -28 30 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
5566 10632 58 3H-PRAZOSIN -28 30 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
66064 10632 58 3H-PRAZOSIN -28 30 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL422 10632 58 3H-PRAZOSIN -28 30 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00831 10632 58 3H-PRAZOSIN -28 30 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
None 223346 0 UNDEFINED 2 6 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
242 7258 124 125I-HEAT -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 125I-HEAT -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 125I-HEAT -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 125I-HEAT -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 125I-HEAT -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
16041449 101995 0 UNDEFINED 1 4 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 None
CHEMBL256040 101995 0 UNDEFINED 1 4 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
242 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
138107169 222731 0 125I-HEAT -676 23 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
22831402 222731 0 125I-HEAT -676 23 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O None
242 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
34 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
60795 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL1112 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB01238 7258 124 3H-PRAZOSIN -18 51 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl None
16041629 102221 0 UNDEFINED -1 4 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 None
CHEMBL257097 102221 0 UNDEFINED -1 4 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
16041628 162129 0 UNDEFINED -1 4 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 None
CHEMBL403280 162129 0 UNDEFINED -1 4 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 None
1830 9368 44 3H-PRAZOSIN -467 28 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
207 9368 44 3H-PRAZOSIN -467 28 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
23897 9368 44 3H-PRAZOSIN -467 28 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
CHEMBL460 9368 44 3H-PRAZOSIN -467 28 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
DB01618 9368 44 3H-PRAZOSIN -467 28 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 276 3 1 3 2.0 CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1 None
3337 213146 27 125I-HEAT -245 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
65801 213146 27 125I-HEAT -245 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
66264 213146 27 125I-HEAT -245 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
91452 213146 27 125I-HEAT -245 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
CHEMBL87493 213146 27 125I-HEAT -245 40 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 231 4 1 1 3.2 CCNC(C)Cc1cccc(C(F)(F)F)c1 None
None 223346 0 UNDEFINED 2 6 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
68617 212306 62 3H-PRAZOSIN -40 26 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 None
CHEMBL1709 212306 62 3H-PRAZOSIN -40 26 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 None
CHEMBL809 212306 62 3H-PRAZOSIN -40 26 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 None
None 223120 0 3H-PRAZOSIN -288 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 451 8 2 4 3.2 CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C None
1353 8692 93 3H-PRAZOSIN -19 85 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-PRAZOSIN -19 85 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-PRAZOSIN -19 85 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-PRAZOSIN -19 85 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-PRAZOSIN -19 85 Rat 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
16041264 102218 0 UNDEFINED 1 4 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 None
CHEMBL257077 102218 0 UNDEFINED 1 4 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 None
2105 9828 37 3H-PRAZOSIN -72 32 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 3H-PRAZOSIN -72 32 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 3H-PRAZOSIN -72 32 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 3H-PRAZOSIN -72 32 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 3H-PRAZOSIN -72 32 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
16041263 102222 0 UNDEFINED 1 4 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 None
CHEMBL257098 102222 0 UNDEFINED 1 4 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
16041628 162129 0 UNDEFINED -1 4 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 None
CHEMBL403280 162129 0 UNDEFINED -1 4 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 None
3157 8252 71 UNDEFINED -1 12 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
7170 8252 71 UNDEFINED -1 12 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
954 8252 71 UNDEFINED -1 12 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
CHEMBL707 8252 71 UNDEFINED -1 12 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
DB00590 8252 71 UNDEFINED -1 12 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
2398 7741 62 3H-PRAZOSIN -1 29 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
2801 7741 62 3H-PRAZOSIN -1 29 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
701 7741 62 3H-PRAZOSIN -1 29 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
CHEMBL415 7741 62 3H-PRAZOSIN -1 29 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
DB01242 7741 62 3H-PRAZOSIN -1 29 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
None 223346 0 UNDEFINED 2 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2601 10552 33 3H-PRAZOSIN -5 21 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
443951 10552 33 3H-PRAZOSIN -5 21 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
56 10552 33 3H-PRAZOSIN -5 21 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL73151 10552 33 3H-PRAZOSIN -5 21 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
DB13399 10552 33 3H-PRAZOSIN -5 21 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
16041092 102155 0 UNDEFINED 1 4 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 None
CHEMBL256804 102155 0 UNDEFINED 1 4 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 None
None 223405 0 UNDEFINED 11 4 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 359 1 2 3 5.3 CC1=CC=CC=C1N2C3=CC=CC=C3C(CC(C4=CC=CC=C42)(C)O)(C)O None
16041449 101995 0 UNDEFINED 1 4 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 None
CHEMBL256040 101995 0 UNDEFINED 1 4 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2601 10552 33 3H-PRAZOSIN -5 21 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
443951 10552 33 3H-PRAZOSIN -5 21 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
56 10552 33 3H-PRAZOSIN -5 21 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL73151 10552 33 3H-PRAZOSIN -5 21 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
DB13399 10552 33 3H-PRAZOSIN -5 21 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
None 223346 0 UNDEFINED 2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1613 9127 53 125I-HEAT -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
1613 9127 53 3H-PRAZOSIN -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 125I-HEAT -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
205 9127 53 3H-PRAZOSIN -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 125I-HEAT -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
3964 9127 53 3H-PRAZOSIN -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 125I-HEAT -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
CHEMBL831 9127 53 3H-PRAZOSIN -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 125I-HEAT -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
DB00408 9127 53 3H-PRAZOSIN -8 44 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 327 0 0 4 3.8 CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2 None
None 223346 0 UNDEFINED 2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2803 7742 58 3H-PRAZOSIN -12 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 3H-PRAZOSIN -12 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 3H-PRAZOSIN -12 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 3H-PRAZOSIN -12 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 3H-PRAZOSIN -12 19 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
102 10899 48 125I-BE2254 -363 49 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 125I-BE2254 -363 49 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 125I-BE2254 -363 49 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 125I-BE2254 -363 49 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 125I-BE2254 -363 49 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
1427 8794 54 3H-PRAZOSIN -3 27 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
357 8794 54 3H-PRAZOSIN -3 27 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
3696 8794 54 3H-PRAZOSIN -3 27 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
CHEMBL11 8794 54 3H-PRAZOSIN -3 27 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
DB00458 8794 54 3H-PRAZOSIN -3 27 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 280 4 0 2 3.9 CN(CCCN1c2ccccc2CCc2c1cccc2)C None
None 223346 0 UNDEFINED 2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223018 0 125I-HEAT -13489 29 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 316 7 3 3 3.0 CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O None
16041265 102112 0 UNDEFINED 1 4 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 None
CHEMBL256597 102112 0 UNDEFINED 1 4 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 None
16041451 104584 0 UNDEFINED -1 4 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
CHEMBL271913 104584 0 UNDEFINED -1 4 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1816 9318 102 3H-PRAZOSIN -794 18 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
4205 9318 102 3H-PRAZOSIN -794 18 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
7241 9318 102 3H-PRAZOSIN -794 18 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
CHEMBL654 9318 102 3H-PRAZOSIN -794 18 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
DB00370 9318 102 3H-PRAZOSIN -794 18 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1 None
16040907 104659 0 UNDEFINED 2 4 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
CHEMBL272340 104659 0 UNDEFINED 2 4 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2771 201796 74 3H-PRAZOSIN -9 27 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL1200781 201796 74 3H-PRAZOSIN -9 27 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL549 201796 74 3H-PRAZOSIN -9 27 Human 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
None 222806 0 3H-PRAZOSIN -251 13 Rat 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 453 9 2 6 2.6 COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl None
180 7189 56 3H-PRAZOSIN -23 40 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 7189 56 3H-PRAZOSIN -23 40 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 7189 56 3H-PRAZOSIN -23 40 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 7189 56 3H-PRAZOSIN -23 40 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 7189 56 3H-PRAZOSIN -23 40 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
None 223346 0 UNDEFINED 2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
31101 7516 40 3H-PRAZOSIN -7 35 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 3H-PRAZOSIN -7 35 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 3H-PRAZOSIN -7 35 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 3H-PRAZOSIN -7 35 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 3H-PRAZOSIN -7 35 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
None 223346 0 UNDEFINED 2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
46780481 114308 20 3H-PRAZOSIN -25 53 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 114308 20 3H-PRAZOSIN -25 53 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 114308 20 3H-PRAZOSIN -25 53 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 114308 20 3H-PRAZOSIN -25 53 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
1753 9282 28 None 1 5 Rat 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
483 9282 28 None 1 5 Rat 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
6082 9282 28 None 1 5 Rat 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
CHEMBL524 9282 28 None 1 5 Rat 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
DB00723 9282 28 None 1 5 Rat 8.4 pKi = 8.4 Binding
NoneNone
Drug Central 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC None
None 223346 0 UNDEFINED 2 6 Human 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
104911 222798 0 3H-PRAZOSIN -50 37 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 530 7 0 5 5.1 COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl None
1210 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
1213 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
2725 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
33036 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
4411 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
616 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
6976 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
716121 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
CHEMBL1201353 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
CHEMBL1554789 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
CHEMBL505 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
DB01114 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
DB13679 7705 51 None -602 21 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 274 5 0 2 3.8 CN(CC[C@H](c1ccccn1)c1ccc(cc1)Cl)C None
None 223020 0 125I-BE2254 2 3 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 609 10 1 8 6.0 CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC None
16041630 104323 0 UNDEFINED -2 4 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 None
CHEMBL270589 104323 0 UNDEFINED -2 4 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
3823 56995 42 None 1 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
76973198 56995 42 None 1 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
CHEMBL157101 56995 42 None 1 11 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
16041263 102222 0 UNDEFINED 1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 None
CHEMBL257098 102222 0 UNDEFINED 1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1890 9535 49 3H-PRAZOSIN -7 16 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
4449 9535 49 3H-PRAZOSIN -7 16 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
7247 9535 49 3H-PRAZOSIN -7 16 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
CHEMBL623 9535 49 3H-PRAZOSIN -7 16 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
DB01149 9535 49 3H-PRAZOSIN -7 16 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl None
16041263 102222 0 UNDEFINED 1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 None
CHEMBL257098 102222 0 UNDEFINED 1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2389 10104 118 125I-HEAT -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
2389 10104 118 3H-PRAZOSIN -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 125I-HEAT -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-PRAZOSIN -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 125I-HEAT -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-PRAZOSIN -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 125I-HEAT -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-PRAZOSIN -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 125I-HEAT -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-PRAZOSIN -24 66 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
100 10577 58 3H-PRAZOSIN -1 54 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 3H-PRAZOSIN -1 54 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 3H-PRAZOSIN -1 54 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 3H-PRAZOSIN -1 54 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 3H-PRAZOSIN -1 54 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
None 223346 0 UNDEFINED 2 6 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
162265 209053 22 None -5 44 Rat 8.3 pKi = 8.3 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
4786 209053 22 None -5 44 Rat 8.3 pKi = 8.3 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
CHEMBL61006 209053 22 None -5 44 Rat 8.3 pKi = 8.3 Binding
Binding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assayBinding affinity to Rattus norvegicus (rat) alpha1D adrenoreceptor by radioligand displacement assay
Drug Central 151 2 2 2 1.1 CC(N)C(O)c1ccccc1 None
16041264 102218 0 UNDEFINED 1 4 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 None
CHEMBL257077 102218 0 UNDEFINED 1 4 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 470 6 2 4 5.4 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2812 11551 101 None -40 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
CHEMBL104 11551 101 None -40 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
None 223346 0 UNDEFINED 2 6 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2162 48288 100 None -4 6 Human 8.3 pKi = 8.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
Drug Central 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl None
CHEMBL1491 48288 100 None -4 6 Human 8.3 pKi = 8.3 Binding
Binding affinity against human Alpha-1d adrenergic receptorBinding affinity against human Alpha-1d adrenergic receptor
Drug Central 408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl None
441383 27105 57 None -9 17 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
CHEMBL1306 27105 57 None -9 17 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 None
448537 167029 89 None -33 25 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 None
CHEMBL411 167029 89 None -33 25 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 None
16041630 104323 0 UNDEFINED -2 4 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 None
CHEMBL270589 104323 0 UNDEFINED -2 4 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 None
3198 212292 76 None -30 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1201049 212292 76 None -30 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL808 212292 76 None -30 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
None 223346 0 UNDEFINED 2 6 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1588 9105 27 3H-PRAZOSIN -20 44 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 3H-PRAZOSIN -20 44 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 3H-PRAZOSIN -20 44 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 3H-PRAZOSIN -20 44 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 3H-PRAZOSIN -20 44 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
None 223346 0 UNDEFINED 2 6 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
10219 195575 37 None 1 5 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 480 7 1 6 4.9 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 None
CHEMBL493439 195575 37 None 1 5 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 480 7 1 6 4.9 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 None
CHEMBL50588 195575 37 None 1 5 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 480 7 1 6 4.9 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 None
1599 9120 50 None -6 16 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 None
3955 9120 50 None -6 16 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 None
7215 9120 50 None -6 16 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 None
CHEMBL841 9120 50 None -6 16 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 None
DB00836 9120 50 None -6 16 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 476 7 1 3 5.1 Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1 None
2291 9958 58 None 1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O None
2561 9958 58 None 1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O None
4932 9958 58 None 1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O None
CHEMBL631 9958 58 None 1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O None
DB01182 9958 58 None 1 12 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 341 11 2 4 3.2 CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O None
164739 7949 40 None 446 2 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N None
4482 7949 40 None 446 2 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N None
508 7949 40 None 446 2 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N None
CHEMBL677 7949 40 None 446 2 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N None
DB06707 7949 40 None 446 2 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N None
None 223346 0 UNDEFINED 2 6 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1016 10519 78 None -22 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2561 10519 78 None -22 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2733526 10519 78 None -22 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5384 10519 78 None -22 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
CHEMBL83 10519 78 None -22 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
DB00675 10519 78 None -22 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
3652 53018 70 None 1 9 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 None
CHEMBL1535 53018 70 None 1 9 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 None
1530 8963 50 None -104 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
3827 8963 50 None -104 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
7206 8963 50 None -104 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
CHEMBL534 8963 50 None -104 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
DB00920 8963 50 None -104 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 309 0 0 3 4.0 CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
4189 213701 96 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 213701 96 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 213701 96 None -18 34 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
57469 25638 125 None 1 3 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 240 2 1 4 2.8 CC(C)Cn1cnc2c(N)nc3ccccc3c21 None
CHEMBL1282 25638 125 None 1 3 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 240 2 1 4 2.8 CC(C)Cn1cnc2c(N)nc3ccccc3c21 None
104870 105656 47 None -22 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
5374 105656 47 None -22 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
CHEMBL279085 105656 47 None -22 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 209 2 1 4 1.3 C=CCN1CCc2nc(N)sc2CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1935 10506 97 None 6 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 None
2551 10506 97 None 6 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 None
6687 10506 97 None 6 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 None
CHEMBL95 10506 97 None 6 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 None
DB00382 10506 97 None 6 6 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 198 0 1 2 2.7 Nc1c2CCCCc2nc2c1cccc2 None
237 211644 48 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 None
CHEMBL546257 211644 48 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 None
CHEMBL554190 211644 48 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 None
CHEMBL7568 211644 48 None -1 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12 None
41 8440 0 3H-PRAZOSIN -199 17 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 195 0 1 3 0.9 Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 None
72036 8440 0 3H-PRAZOSIN -199 17 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 195 0 1 3 0.9 Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 None
CHEMBL1765294 8440 0 3H-PRAZOSIN -199 17 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 195 0 1 3 0.9 Fc1cccc2c1O[C@H]1CNC[C@@H]1O2 None
16041449 101995 0 UNDEFINED 1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 None
CHEMBL256040 101995 0 UNDEFINED 1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 None
16041092 102155 0 UNDEFINED 1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 None
CHEMBL256804 102155 0 UNDEFINED 1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 None
None 223020 0 125I-BE2254 2 3 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 609 10 1 8 6.0 CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC None
16041629 102221 0 UNDEFINED -1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 None
CHEMBL257097 102221 0 UNDEFINED -1 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 None
16041630 104323 0 UNDEFINED -2 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 None
CHEMBL270589 104323 0 UNDEFINED -2 4 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1028 7079 71 125I-HEAT -22 30 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
139148732 7079 71 125I-HEAT -22 30 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
479 7079 71 125I-HEAT -22 30 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
5816 7079 71 125I-HEAT -22 30 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL679 7079 71 125I-HEAT -22 30 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
DB00668 7079 71 125I-HEAT -22 30 Rat 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
None 223346 0 UNDEFINED 2 6 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
4508 9913 98 None -1 13 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
4866774 9913 98 None -1 13 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
509 9913 98 None -1 13 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
838 9913 98 None -1 13 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
CHEMBL1740 9913 98 None -1 13 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNCC(c1ccc(c(c1)O)O)O None
None 223346 0 UNDEFINED 2 6 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
11057 182928 23 None -2 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
3468 182928 23 None -2 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
CHEMBL459265 182928 23 None -2 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
CHEMBL64894 182928 23 None -2 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 None
3191 109635 97 None -14 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 None
CHEMBL305660 109635 97 None -14 25 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 None
2435 7509 100 None -28 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
395 7509 100 None -28 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
520 7509 100 None -28 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
5386 7509 100 None -28 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
CHEMBL844 7509 100 None -28 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
DB00484 7509 100 None -28 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1 None
2520 210787 70 None -1 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 454 13 0 6 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC None
CHEMBL1280 210787 70 None -1 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 454 13 0 6 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC None
CHEMBL6966 210787 70 None -1 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 454 13 0 6 5.1 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC None
2105 9828 37 None -72 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
47811 9828 37 None -72 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
48 9828 37 None -72 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
CHEMBL531 9828 37 None -72 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
DB01186 9828 37 None -72 32 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3 None
2771 201796 74 None -9 27 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL1200781 201796 74 None -9 27 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
CHEMBL549 201796 74 None -9 27 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 324 5 0 3 3.8 CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 None
12057539 214820 42 None -11 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 289 4 1 4 1.9 CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 None
3661 214820 42 None -11 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 289 4 1 4 1.9 CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 None
CHEMBL9751 214820 42 None -11 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 289 4 1 4 1.9 CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 None
16041265 102112 0 UNDEFINED 1 4 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 None
CHEMBL256597 102112 0 UNDEFINED 1 4 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 504 6 2 4 6.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1443 8809 34 None -27 11 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
33625 8809 34 None -27 11 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
501 8809 34 None -27 11 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
CHEMBL279516 8809 34 None -27 11 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
DB08950 8809 34 None -27 11 Rat 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
2803 7742 58 None -12 19 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 None -12 19 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 None -12 19 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 None -12 19 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 None -12 19 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
6726 8063 51 None -11 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
7151 8063 51 None -11 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
749 8063 51 None -11 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
CHEMBL648 8063 51 None -11 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
DB01176 8063 51 None -11 13 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 266 3 0 2 3.0 CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
33630 185736 99 None -10 28 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assay
Drug Central 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
CHEMBL47050 185736 99 None -10 28 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assay
Drug Central 523 7 1 2 7.5 OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 None
1547484 7727 74 None -9 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
654 7727 74 None -9 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
9072 7727 74 None -9 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
CHEMBL43064 7727 74 None -9 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
DB00568 7727 74 None -9 20 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 368 6 0 2 5.1 c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1 None
1343 8670 62 None 3 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
3519 8670 62 None 3 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
522 8670 62 None 3 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
CHEMBL862 8670 62 None 3 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
DB01018 8670 62 None 3 9 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N None
2477 7532 59 None -8 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
36 7532 59 None -8 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
437 7532 59 None -8 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
CHEMBL49 7532 59 None -8 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
DB00490 7532 59 None -8 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 385 6 0 6 2.1 O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 None
1028 7079 71 None -22 30 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
139148732 7079 71 None -22 30 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
479 7079 71 None -22 30 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
5816 7079 71 None -22 30 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL679 7079 71 None -22 30 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
DB00668 7079 71 None -22 30 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
3584 10549 64 UNDEFINED -1 14 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
5401 10549 64 UNDEFINED -1 14 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
7302 10549 64 UNDEFINED -1 14 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
CHEMBL611 10549 64 UNDEFINED -1 14 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
DB01162 10549 64 UNDEFINED -1 14 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
None 223346 0 UNDEFINED 2 6 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
4735 201894 96 None 6 10 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 340 10 4 4 2.9 N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1 None
CHEMBL361506 201894 96 None 6 10 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 340 10 4 4 2.9 N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1 None
CHEMBL55 201894 96 None 6 10 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 340 10 4 4 2.9 N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1 None
2351 10059 64 None -8 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
2820 10059 64 None -8 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
5035 10059 64 None -8 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
CHEMBL81 10059 64 None -8 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
DB00481 10059 64 None -8 21 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
12488 8438 56 None -10 23 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F None
941361 8438 56 None -10 23 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F None
CHEMBL30008 8438 56 None -10 23 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F None
DB04841 8438 56 None -10 23 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 404 6 0 2 5.4 C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F None
124 9755 47 None -524 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 None -524 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 None -524 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 None -524 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 None -524 32 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
1212 8443 50 125I-HEAT -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 125I-HEAT -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 125I-HEAT -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 125I-HEAT -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 125I-HEAT -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
124 9755 47 None -338 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
2032 9755 47 None -338 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
4636 9755 47 None -338 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
CHEMBL762 9755 47 None -338 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
DB00935 9755 47 None -338 32 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C None
1212 8443 50 3H-PRAZOSIN -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 3H-PRAZOSIN -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 3H-PRAZOSIN -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 3H-PRAZOSIN -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 3H-PRAZOSIN -18 65 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
16041449 101995 0 UNDEFINED 1 4 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 None
CHEMBL256040 101995 0 UNDEFINED 1 4 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 538 6 2 4 6.7 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 None
1028 7079 71 None -17 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
139148732 7079 71 None -17 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
479 7079 71 None -17 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
5816 7079 71 None -17 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL679 7079 71 None -17 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
DB00668 7079 71 None -17 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O None
2202 9906 96 None -3 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
4850 9906 96 None -3 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
49 9906 96 None -3 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
CHEMBL1371770 9906 96 None -3 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
DB12478 9906 96 None -3 21 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
11154555 7587 62 None -28 12 Human 8.2 pKi = 8.2 Binding
HEK-293 cells, [3H]Prazosin (0.6nM)HEK-293 cells, [3H]Prazosin (0.6nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
5037 7587 62 None -28 12 Human 8.2 pKi = 8.2 Binding
HEK-293 cells, [3H]Prazosin (0.6nM)HEK-293 cells, [3H]Prazosin (0.6nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
7671 7587 62 None -28 12 Human 8.2 pKi = 8.2 Binding
HEK-293 cells, [3H]Prazosin (0.6nM)HEK-293 cells, [3H]Prazosin (0.6nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL2028019 7587 62 None -28 12 Human 8.2 pKi = 8.2 Binding
HEK-293 cells, [3H]Prazosin (0.6nM)HEK-293 cells, [3H]Prazosin (0.6nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
CHEMBL3085826 7587 62 None -28 12 Human 8.2 pKi = 8.2 Binding
HEK-293 cells, [3H]Prazosin (0.6nM)HEK-293 cells, [3H]Prazosin (0.6nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
DB06016 7587 62 None -28 12 Human 8.2 pKi = 8.2 Binding
HEK-293 cells, [3H]Prazosin (0.6nM)HEK-293 cells, [3H]Prazosin (0.6nM)
Drug Central 426 5 1 3 4.3 O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl None
4011 89183 49 None -19 24 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 None
CHEMBL21731 89183 49 None -19 24 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12 None
463 8187 22 None -50 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
6918097 8187 22 None -50 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
837 8187 22 None -50 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
CHEMBL2051956 8187 22 None -50 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
DB14068 8187 22 None -50 13 Human 8.2 pKi = 8.2 Binding
Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptorAbility to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
3952 8669 38 None -6 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
5353646 8669 38 None -6 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
5443 8669 38 None -6 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
5702063 8669 38 None -6 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
CHEMBL1331786 8669 38 None -6 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
CHEMBL420 8669 38 None -6 12 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N None
191 7191 98 None -23 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
201 7191 98 None -23 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
2170 7191 98 None -23 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
CHEMBL1113 7191 98 None -23 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
DB00543 7191 98 None -23 29 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 None
2803 7742 58 None -2 19 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
516 7742 58 None -2 19 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
704 7742 58 None -2 19 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
CHEMBL134 7742 58 None -2 19 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
DB00575 7742 58 None -2 19 Rat 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl None
277 8083 62 None -42 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
2913 8083 62 None -42 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
765 8083 62 None -42 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
CHEMBL516 8083 62 None -42 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
DB00434 8083 62 None -42 50 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 None
1971 9641 38 None -6 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
2404 9641 38 None -6 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
4543 9641 38 None -6 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
CHEMBL445 9641 38 None -6 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
DB00540 9641 38 None -6 30 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2c1cccc2 None
3151 8244 97 None -77 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
945 8244 97 None -77 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
965 8244 97 None -77 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
CHEMBL219916 8244 97 None -77 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
DB01184 8244 97 None -77 26 Human 8.2 pKi = 8.2 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2 None
1443 8809 34 None -16 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
33625 8809 34 None -16 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
501 8809 34 None -16 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
CHEMBL279516 8809 34 None -16 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
DB08950 8809 34 None -16 11 Human 8.2 pKi = 8.2 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
135398745 9688 112 UNDEFINED -24 65 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 UNDEFINED -24 65 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 UNDEFINED -24 65 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 UNDEFINED -24 65 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
None 223346 0 UNDEFINED 2 6 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
15897 9637 0 125I-HEAT -275 36 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
215 9637 0 125I-HEAT -275 36 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
CHEMBL1979333 9637 0 125I-HEAT -275 36 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
None 223346 0 UNDEFINED 2 6 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1443 8809 34 125I-HEAT -27 11 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
33625 8809 34 125I-HEAT -27 11 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
501 8809 34 125I-HEAT -27 11 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
CHEMBL279516 8809 34 125I-HEAT -27 11 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
DB08950 8809 34 125I-HEAT -27 11 Rat 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 None
None 223018 0 125I-HEAT -13489 29 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 316 7 3 3 3.0 CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O None
16041091 101996 0 UNDEFINED -1 4 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 None
CHEMBL256041 101996 0 UNDEFINED -1 4 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 None
68602 211905 80 3H-PRAZOSIN -18 8 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
CHEMBL77921 211905 80 3H-PRAZOSIN -18 8 Rat 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
16041451 104584 0 UNDEFINED -1 4 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
CHEMBL271913 104584 0 UNDEFINED -1 4 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 500 7 2 5 5.4 COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
25058166 222739 0 3H-PRAZOSIN -177 26 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
6852389 222739 0 3H-PRAZOSIN -177 26 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 267 0 2 3 2.9 CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O None
None 223346 0 UNDEFINED 2 6 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
103 10925 61 125I-HEAT -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 125I-HEAT -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 125I-HEAT -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 125I-HEAT -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 125I-HEAT -5 53 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
None 223346 0 UNDEFINED 2 6 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
463 8187 22 None -6 13 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
6918097 8187 22 None -6 13 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
837 8187 22 None -6 13 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
CHEMBL2051956 8187 22 None -6 13 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
DB14068 8187 22 None -6 13 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligandBinding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand
Drug Central 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C None
228 7233 28 None -1 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
33 7233 28 None -1 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
6005 7233 28 None -1 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
CHEMBL53 7233 28 None -1 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
DB00714 7233 28 None -1 23 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O None
6075 156887 42 None -4 16 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 None
CHEMBL395110 156887 42 None -4 16 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 310 2 0 3 4.6 CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 None
102 10899 48 None -48 49 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 None -48 49 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 None -48 49 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 None -48 49 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 None -48 49 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
None 223346 0 UNDEFINED 2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
240 7731 43 None -5 25 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
2769 7731 43 None -5 25 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
44279790 7731 43 None -5 25 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
660 7731 43 None -5 25 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL1729 7731 43 None -5 25 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
CHEMBL560739 7731 43 None -5 25 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
DB00604 7731 43 None -5 25 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N None
213 10625 55 None -4 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
2717 10625 55 None -4 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
5533 10625 55 None -4 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
CHEMBL621 10625 55 None -4 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
DB00656 10625 55 None -4 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 None
36811 8236 37 None 1 7 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
535 8236 37 None 1 7 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
937 8236 37 None 1 7 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
CHEMBL926 8236 37 None 1 7 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
DB00841 8236 37 None 1 7 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 301 7 4 4 3.0 CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O None
2142 9870 58 None -12 37 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
4920903 9870 58 None -12 37 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
502 9870 58 None -12 37 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
5775 9870 58 None -12 37 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
CHEMBL597 9870 58 None -12 37 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
DB00692 9870 58 None -12 37 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
1225 8253 26 None -26 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
3958 8253 26 None -26 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
667477 8253 26 None -26 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
CHEMBL860 8253 26 None -26 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
DB01142 8253 26 None -26 22 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 279 3 0 2 4.0 CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C None
2398 7741 62 None -1 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
2801 7741 62 None -1 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
701 7741 62 None -1 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
CHEMBL415 7741 62 None -1 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
DB01242 7741 62 None -1 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 314 4 0 2 4.5 CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C None
1960 9632 67 None -10 26 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
439260 9632 67 None -10 26 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
505 9632 67 None -10 26 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
CHEMBL1437 9632 67 None -10 26 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
DB00368 9632 67 None -10 26 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O None
2389 10104 118 None -24 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 None -24 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 None -24 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 None -24 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 None -24 66 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
133 9274 52 None -41 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
1723 9274 52 None -41 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
28693 9274 52 None -41 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
CHEMBL19215 9274 52 None -41 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
DB13520 9274 52 None -41 43 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C None
2337 10030 77 None -2 62 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 None -2 62 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 None -2 62 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 None -2 62 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 None -2 62 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2286 9957 51 None -8 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
4927 9957 51 None -8 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
7282 9957 51 None -8 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
CHEMBL643 9957 51 None -8 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
DB01069 9957 51 None -8 30 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C None
135 9310 43 None -10 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
1796 9310 43 None -10 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
4184 9310 43 None -10 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
CHEMBL6437 9310 43 None -10 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
DB06148 9310 43 None -10 56 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 None
None 223346 0 UNDEFINED 2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
1353 8692 93 None -10 85 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 None -10 85 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 None -10 85 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 None -10 85 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 None -10 85 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
1201549 7384 24 None -12 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
333 7384 24 None -12 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
7601 7384 24 None -12 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
CHEMBL1201203 7384 24 None -12 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
CHEMBL438151 7384 24 None -12 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
DB00245 7384 24 None -12 20 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1 None
135398745 9688 112 None -24 65 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 None -24 65 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 None -24 65 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 None -24 65 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
1531 9046 69 None -14 16 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O None
3869 9046 69 None -14 16 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O None
7207 9046 69 None -14 16 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O None
CHEMBL429 9046 69 None -14 16 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O None
DB00598 9046 69 None -14 16 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O None
2470 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 None -389 58 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
135398737 7745 93 None -2 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 None -2 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 None -2 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 None -2 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 None -2 90 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
2142 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
4920903 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
502 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
5775 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
CHEMBL597 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
DB00692 9870 58 None -5 37 Human 8.1 pKi = 8.1 Binding
Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
Drug Central 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 None
1524 8962 96 None -8 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
197 8962 96 None -8 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
3822 8962 96 None -8 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
88 8962 96 None -8 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
CHEMBL51 8962 96 None -8 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
DB12465 8962 96 None -8 51 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 None
135398737 7745 93 3H-PRAZOSIN -3 90 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-PRAZOSIN -3 90 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-PRAZOSIN -3 90 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-PRAZOSIN -3 90 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-PRAZOSIN -3 90 Rat 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
26987 7736 33 None -39 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
6063 7736 33 None -39 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
671 7736 33 None -39 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
CHEMBL1626 7736 33 None -39 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
DB00283 7736 33 None -39 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C None
2274 9947 58 None -5 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
4917 9947 58 None -5 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
7279 9947 58 None -5 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
CHEMBL728 9947 58 None -5 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
DB00433 9947 58 None -5 31 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2 None
5639 105671 75 None -1 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 387 7 1 8 0.7 COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 None
CHEMBL279229 105671 75 None -1 5 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 387 7 1 8 0.7 COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
179 7188 115 3H-PRAZOSIN -3090 50 Rat 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
2159 7188 115 3H-PRAZOSIN -3090 50 Rat 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
963 7188 115 3H-PRAZOSIN -3090 50 Rat 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
CHEMBL243712 7188 115 3H-PRAZOSIN -3090 50 Rat 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
DB06288 7188 115 3H-PRAZOSIN -3090 50 Rat 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 369 7 2 6 1.3 CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC None
16041092 102155 0 UNDEFINED 1 4 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 None
CHEMBL256804 102155 0 UNDEFINED 1 4 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 None
16040907 104659 0 UNDEFINED 2 4 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
CHEMBL272340 104659 0 UNDEFINED 2 4 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
16041090 102168 0 UNDEFINED 1 4 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 None
CHEMBL256853 102168 0 UNDEFINED 1 4 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 None
None 223346 0 UNDEFINED 2 6 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
15897 9637 0 125I-HEAT -275 36 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
215 9637 0 125I-HEAT -275 36 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
CHEMBL1979333 9637 0 125I-HEAT -275 36 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 203 2 1 1 2.6 CC(Cc1cccc(c1)C(F)(F)F)N None
68602 211905 80 3H-PRAZOSIN -37 8 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
CHEMBL77921 211905 80 3H-PRAZOSIN -37 8 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 200 2 1 1 3.2 Cc1cccc(C(C)c2c[nH]cn2)c1C None
2247 7293 81 None -31 42 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
249 7293 81 None -31 42 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2603 7293 81 None -31 42 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
CHEMBL296419 7293 81 None -31 42 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
DB00637 7293 81 None -31 42 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
1212 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
204 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
3372 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
CHEMBL726 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
DB00623 8443 50 None -18 65 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F None
1588 9105 27 None -20 44 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
28864 9105 27 None -20 44 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
43 9105 27 None -20 44 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL157138 9105 27 None -20 44 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
DB00589 9105 27 None -20 44 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC None
2470 10425 50 None -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 None -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 None -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 None -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 None -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
180 7189 56 None -23 40 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
200 7189 56 None -23 40 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2160 7189 56 None -23 40 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
CHEMBL629 7189 56 None -23 40 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
DB00321 7189 56 None -23 40 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C None
2470 10425 50 3H-PRAZOSIN -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3300 10425 50 3H-PRAZOSIN -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
5265 10425 50 3H-PRAZOSIN -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
99 10425 50 3H-PRAZOSIN -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL267930 10425 50 3H-PRAZOSIN -309 58 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
134551 7146 27 None -10 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
271 7146 27 None -10 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
885 7146 27 None -10 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
CHEMBL1403281 7146 27 None -10 21 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C None
3033538 8101 39 None 1 9 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
7155 8101 39 None 1 9 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
781 8101 39 None 1 9 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
CHEMBL1201216 8101 39 None 1 9 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
DB00298 8101 39 None 1 9 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 None
2284 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
4926 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
7281 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
CHEMBL564 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
DB00420 9956 33 None -3 29 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C None
115 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
2092 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
7109 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
CHEMBL709 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
DB00346 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
115 7131 71 None -1 7 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
2092 7131 71 None -1 7 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
7109 7131 71 None -1 7 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
CHEMBL709 7131 71 None -1 7 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
DB00346 7131 71 None -1 7 Rat 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from rat clones.Binding affinity against Alpha-1D adrenergic receptor, from rat clones.
Drug Central 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C None
11954224 222732 0 None -4073 59 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
None 223346 0 UNDEFINED 2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
31101 7516 40 None -7 35 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
35 7516 40 None -7 35 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
403 7516 40 None -7 35 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
CHEMBL493 7516 40 None -7 35 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
DB01200 7516 40 None -7 35 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C None
11978813 7508 79 None -10 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
5014 7508 79 None -10 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
7672 7508 79 None -10 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
CHEMBL2105760 7508 79 None -10 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
DB09128 7508 79 None -10 24 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 433 7 1 5 4.7 O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2 None
None 223346 0 UNDEFINED 2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
10531 8202 21 None -28 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
121 8202 21 None -28 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
888 8202 21 None -28 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
CHEMBL1732 8202 21 None -28 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
DB00320 8202 21 None -28 24 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
100 10577 58 None -1 54 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
2637 10577 58 None -1 54 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
5452 10577 58 None -1 54 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
CHEMBL479 10577 58 None -1 54 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
DB00679 10577 58 None -1 54 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 None
4151 10379 89 None -33 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N None
493 10379 89 None -33 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N None
5312125 10379 89 None -33 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N None
CHEMBL24778 10379 89 None -33 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N None
DB06207 10379 89 None -33 3 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N None
16040907 104659 0 UNDEFINED 2 4 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
CHEMBL272340 104659 0 UNDEFINED 2 4 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 466 7 2 5 4.7 COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 8.1 pKi = 8.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
2726 7706 68 None 1 72 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
621 7706 68 None 1 72 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
83 7706 68 None 1 72 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL71 7706 68 None 1 72 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
DB00477 7706 68 None 1 72 Human 8.1 pKi = 8.1 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C None
102 10899 48 None -363 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 None -363 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 None -363 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 None -363 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 None -363 49 Human 8.1 pKi = 8.1 Binding
Binding affinity against Alpha-1D adrenergic receptor, from human clones.Binding affinity against Alpha-1D adrenergic receptor, from human clones.
Drug Central 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3157 8252 71 None -1 12 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
7170 8252 71 None -1 12 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
954 8252 71 None -1 12 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
CHEMBL707 8252 71 None -1 12 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
DB00590 8252 71 None -1 12 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 None
4418 40996 85 None 1 7 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 None
CHEMBL142635 40996 85 None 1 7 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 392 7 1 5 3.4 COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 None
2202 9906 96 3H-PRAZOSIN -3 21 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
4850 9906 96 3H-PRAZOSIN -3 21 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
49 9906 96 3H-PRAZOSIN -3 21 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
CHEMBL1371770 9906 96 3H-PRAZOSIN -3 21 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
DB12478 9906 96 3H-PRAZOSIN -3 21 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 298 3 0 6 1.5 c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2 None
16041091 101996 0 UNDEFINED -1 4 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 None
CHEMBL256041 101996 0 UNDEFINED -1 4 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 468 7 2 4 4.5 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 None
None 223346 0 UNDEFINED 2 6 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
484 9633 51 125I-BE2254 -93 35 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
951 9633 51 125I-BE2254 -93 35 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
CHEMBL432 9633 51 125I-BE2254 -93 35 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 169 2 4 4 0.1 NCC(c1ccc(c(c1)O)O)O None
3584 10549 64 None -1 14 Rat 8.1 pKi = 8.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
5401 10549 64 None -1 14 Rat 8.1 pKi = 8.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
7302 10549 64 None -1 14 Rat 8.1 pKi = 8.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
CHEMBL611 10549 64 None -1 14 Rat 8.1 pKi = 8.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
DB01162 10549 64 None -1 14 Rat 8.1 pKi = 8.1 Binding
In vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cellIn vitro binding affinity using [3H]prazosin as radioligand against adrenoceptor alpha 1d expressed in LTK cell
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
6761 74574 19 None -1 18 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 None
CHEMBL1909072 74574 19 None -1 18 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 None
2585 7590 103 None -4 22 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
522 7590 103 None -4 22 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
551 7590 103 None -4 22 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
CHEMBL723 7590 103 None -4 22 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
DB01136 7590 103 None -4 22 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O None
1238 209953 24 None -3 16 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
Drug Central 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
CHEMBL64249 209953 24 None -3 16 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prozosin from rat cloned alpha1d receptorDisplacement of [3H]prozosin from rat cloned alpha1d receptor
Drug Central 344 1 0 3 4.3 CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1 None
3168 16034 92 None -29 22 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 None
CHEMBL1108 16034 92 None -29 22 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 None
107715 207724 22 None -13 20 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O None
CHEMBL1255837 207724 22 None -13 20 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O None
CHEMBL601773 207724 22 None -13 20 Human 8.0 pKi = 8.0 Binding
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Drug Central 611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O None
2435 10362 83 None -4 48 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 None -4 48 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 None -4 48 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 None -4 48 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 None -4 48 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
3584 10549 64 None -1 14 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
5401 10549 64 None -1 14 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
7302 10549 64 None -1 14 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
CHEMBL611 10549 64 None -1 14 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
DB01162 10549 64 None -1 14 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 None
None 223346 0 UNDEFINED 2 6 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
None 223346 0 UNDEFINED 2 6 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 158 7 0 2 2.6 CCCCN(CCCC)N=O None
4209 9937 75 None 1 33 Human 8.0 pKi = 8.0 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 None 1 33 Human 8.0 pKi = 8.0 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 None 1 33 Human 8.0 pKi = 8.0 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 None 1 33 Human 8.0 pKi = 8.0 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 None 1 33 Human 8.0 pKi = 8.0 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 None 1 33 Human 8.0 pKi = 8.0 Binding
Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptorCompound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4209 9937 75 None -2 33 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
4893 9937 75 None -2 33 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
503 9937 75 None -2 33 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
5385 9937 75 None -2 33 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
CHEMBL2 9937 75 None -2 33 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
DB00457 9937 75 None -2 33 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsDisplacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells
Drug Central 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 None
16041090 102168 0 UNDEFINED 1 4 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 None
CHEMBL256853 102168 0 UNDEFINED 1 4 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 496 8 2 6 4.7 COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 None
16041630 104323 0 UNDEFINED -2 4 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 None
CHEMBL270589 104323 0 UNDEFINED -2 4 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 472 6 2 4 5.0 CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 None
102 10899 48 125I-BE2254 -363 49 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
3659 10899 48 125I-BE2254 -363 49 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
8969 10899 48 125I-BE2254 -363 49 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
CHEMBL15245 10899 48 125I-BE2254 -363 49 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
DB01392 10899 48 125I-BE2254 -363 49 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 None
13155 10195 0 None 16 3 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 668 12 2 9 4.5 CN(C(CCCC(=O)NC=1C=CC2=C(C1)C=3NC(N(C(C3S2)=O)CCN4CCN(CC4)C5=C(C=CC=C5)OC)=O)=O)CC6=CC=CC=C6 24992070
90645598 10195 0 None 16 3 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 668 12 2 9 4.5 CN(C(CCCC(=O)NC=1C=CC2=C(C1)C=3NC(N(C(C3S2)=O)CCN4CCN(CC4)C5=C(C=CC=C5)OC)=O)=O)CC6=CC=CC=C6 24992070
CHEMBL3297829 10195 0 None 16 3 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 668 12 2 9 4.5 CN(C(CCCC(=O)NC=1C=CC2=C(C1)C=3NC(N(C(C3S2)=O)CCN4CCN(CC4)C5=C(C=CC=C5)OC)=O)=O)CC6=CC=CC=C6 24992070
1753 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
1753 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7651358
483 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
483 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7651358
6082 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
6082 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7651358
CHEMBL524 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
CHEMBL524 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7651358
DB00723 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 34355529
DB00723 9282 28 None -39 5 Human 4.4 pKi = 4.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7651358
2146 9874 67 None -263 9 Human 4.7 pKi = 4.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
485 9874 67 None -263 9 Human 4.7 pKi = 4.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
6041 9874 67 None -263 9 Human 4.7 pKi = 4.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
CHEMBL1215 9874 67 None -263 9 Human 4.7 pKi = 4.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
DB00388 9874 67 None -263 9 Human 4.7 pKi = 4.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 34355529
2765 7730 19 None -91 9 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 34355529
515 7730 19 None -91 9 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 34355529
CHEMBL13852 7730 19 None -91 9 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 34355529
DB09202 7730 19 None -91 9 Human 5.5 pKi = 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 34355529
2803 7742 58 None -12 19 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 34355529
516 7742 58 None -12 19 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 34355529
704 7742 58 None -12 19 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 34355529
CHEMBL134 7742 58 None -12 19 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 34355529
DB00575 7742 58 None -12 19 Human 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 34355529
164739 7949 40 None -446 2 Rat 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N 7969082
4482 7949 40 None -446 2 Rat 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N 7969082
508 7949 40 None -446 2 Rat 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N 7969082
CHEMBL677 7949 40 None -446 2 Rat 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N 7969082
DB06707 7949 40 None -446 2 Rat 5.6 pKi = 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 2 4 4 0.5 C[C@@H]([C@@H](c1ccc(c(c1)O)O)O)N 7969082
498 10403 0 None -2511 2 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 608 10 2 7 5.6 COC(=O)C1=C(C)NC(=C([C@H]1c1ccc(cc1)[N+](=O)[O-])C(=O)NCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 32608144
5311437 10403 0 None -2511 2 Human 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 608 10 2 7 5.6 COC(=O)C1=C(C)NC(=C([C@H]1c1ccc(cc1)[N+](=O)[O-])C(=O)NCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 32608144
124 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
124 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7651358
124 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 8719417
2032 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
2032 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7651358
2032 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 8719417
4636 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
4636 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7651358
4636 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 8719417
CHEMBL762 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
CHEMBL762 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7651358
CHEMBL762 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 8719417
DB00935 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 34355529
DB00935 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7651358
DB00935 9755 47 None -524 32 Human 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 8719417
2146 9874 67 None -5 9 Rat 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 7969082
485 9874 67 None -5 9 Rat 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 7969082
6041 9874 67 None -5 9 Rat 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 7969082
CHEMBL1215 9874 67 None -5 9 Rat 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 7969082
DB00388 9874 67 None -5 9 Rat 5.9 pKi = 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O 7969082
247704 7078 31 None 3 5 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@H](c1ccc(c(c1)O)O)O 7651358
4450 7078 31 None 3 5 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@H](c1ccc(c(c1)O)O)O 7651358
CHEMBL42280 7078 31 None 3 5 Human 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@H](c1ccc(c(c1)O)O)O 7651358
3658 10879 53 None -389 8 Rat 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 7969082
517 10879 53 None -389 8 Rat 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 7969082
5709 10879 53 None -389 8 Rat 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 7969082
CHEMBL312448 10879 53 None -389 8 Rat 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 7969082
DB06694 10879 53 None -389 8 Rat 6.0 pKi = 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 2 1 2 3.1 Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C 7969082
1028 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
1028 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7651358
1028 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 8564227
139148732 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
139148732 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7651358
139148732 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 8564227
479 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
479 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7651358
479 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 8564227
5816 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
5816 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7651358
5816 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 8564227
CHEMBL679 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
CHEMBL679 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7651358
CHEMBL679 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 8564227
DB00668 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 34355529
DB00668 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7651358
DB00668 7079 71 None -17 30 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 8564227
1028 7079 71 None -22 30 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7969082
139148732 7079 71 None -22 30 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7969082
479 7079 71 None -22 30 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7969082
5816 7079 71 None -22 30 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7969082
CHEMBL679 7079 71 None -22 30 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7969082
DB00668 7079 71 None -22 30 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O 7969082
1960 9632 67 None -21 26 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7969082
439260 9632 67 None -21 26 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7969082
505 9632 67 None -21 26 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7969082
CHEMBL1437 9632 67 None -21 26 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7969082
DB00368 9632 67 None -21 26 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7969082
1531 9046 69 None -14 16 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 32608144
3869 9046 69 None -14 16 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 32608144
7207 9046 69 None -14 16 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 32608144
CHEMBL429 9046 69 None -14 16 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 32608144
DB00598 9046 69 None -14 16 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 328 8 5 4 2.9 CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O 32608144
1960 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
1960 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7651358
1960 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 8564227
439260 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
439260 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7651358
439260 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 8564227
505 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
505 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7651358
505 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 8564227
CHEMBL1437 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
CHEMBL1437 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7651358
CHEMBL1437 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 8564227
DB00368 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 34355529
DB00368 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 7651358
DB00368 9632 67 None -10 26 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O 8564227
1443 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 32608144
1443 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 9249248
33625 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 32608144
33625 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 9249248
501 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 32608144
501 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 9249248
CHEMBL279516 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 32608144
CHEMBL279516 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 9249248
DB08950 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 32608144
DB08950 8809 34 None -16 11 Human 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 347 5 2 2 3.6 O=C(c1ccccc1)NC1CCN(CC1)CCc1c[nH]c2c1cccc2 9249248
114697 10459 4 None -1 3 Rat 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 263 1 2 3 2.7 Clc1ccc(cc1NC1=NCCN1)C(F)(F)F 7969082
513 10459 4 None -1 3 Rat 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 263 1 2 3 2.7 Clc1ccc(cc1NC1=NCCN1)C(F)(F)F 7969082
CHEMBL101340 10459 4 None -1 3 Rat 6.5 pKi = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 263 1 2 3 2.7 Clc1ccc(cc1NC1=NCCN1)C(F)(F)F 7969082
487 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 32608144
487 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 7651358
487 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 9249248
60602 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 32608144
60602 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 7651358
60602 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 9249248
CHEMBL405355 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 32608144
CHEMBL405355 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 7651358
CHEMBL405355 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 9249248
DB09239 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 32608144
DB09239 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 7651358
DB09239 10406 21 None -426 12 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 609 10 1 8 6.0 COC(=O)C1=C(C)NC(=C([C@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C 9249248
489 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 11459121
489 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 32608144
489 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 7651358
489 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 9249248
5640 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 11459121
5640 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 32608144
5640 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 7651358
5640 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 9249248
CHEMBL420060 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 11459121
CHEMBL420060 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 32608144
CHEMBL420060 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 7651358
CHEMBL420060 6933 28 None -34 12 Human 6.8 pKi = 6.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C 9249248
3894573 10166 6 None -35 5 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 10 2 3 5.6 Clc1ccc2c(c1)c(c[nH]2)CC(NCCOc1ccccc1OCC1CC1)(C)C 32608144
3894573 10166 6 None -35 5 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 10 2 3 5.6 Clc1ccc2c(c1)c(c[nH]2)CC(NCCOc1ccccc1OCC1CC1)(C)C 9249248
495 10166 6 None -35 5 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 10 2 3 5.6 Clc1ccc2c(c1)c(c[nH]2)CC(NCCOc1ccccc1OCC1CC1)(C)C 32608144
495 10166 6 None -35 5 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 10 2 3 5.6 Clc1ccc2c(c1)c(c[nH]2)CC(NCCOc1ccccc1OCC1CC1)(C)C 9249248
CHEMBL88272 10166 6 None -35 5 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 10 2 3 5.6 Clc1ccc2c(c1)c(c[nH]2)CC(NCCOc1ccccc1OCC1CC1)(C)C 32608144
CHEMBL88272 10166 6 None -35 5 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 412 10 2 3 5.6 Clc1ccc2c(c1)c(c[nH]2)CC(NCCOc1ccccc1OCC1CC1)(C)C 9249248
13154 8195 0 None - 1 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 6 0 1 3.9 C1=CC=C(C=C1)CN(CCCl)CC2=CC=CC=C2 32608144
5820 8195 0 None - 1 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 6 0 1 3.9 C1=CC=C(C=C1)CN(CCCl)CC2=CC=CC=C2 32608144
CHEMBL3305685 8195 0 None - 1 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 259 6 0 1 3.9 C1=CC=C(C=C1)CN(CCCl)CC2=CC=CC=C2 32608144
2142 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 32608144
2142 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7651358
4920903 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 32608144
4920903 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7651358
502 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 32608144
502 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7651358
5775 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 32608144
5775 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7651358
CHEMBL597 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 32608144
CHEMBL597 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7651358
DB00692 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 32608144
DB00692 9870 58 None -5 37 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1 7651358
10453764 8979 0 None 1 3 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 402 4 0 8 0.9 Clc1ccccc1N1CCN(CC1)CCn1cnc2c1c(=O)n(C)c(=O)n2C 17639498
8896 8979 0 None 1 3 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 402 4 0 8 0.9 Clc1ccccc1N1CCN(CC1)CCn1cnc2c1c(=O)n(C)c(=O)n2C 17639498
3567002 10160 9 None -58 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 7 1 6 2.0 O=c1[nH]cc(c(=O)n1CCCN1CCN(CC1)c1ccccc1OCC(F)(F)F)C 10369480
3567002 10160 9 None -58 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 7 1 6 2.0 O=c1[nH]cc(c(=O)n1CCCN1CCN(CC1)c1ccccc1OCC(F)(F)F)C 32608144
7381 10160 9 None -58 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 7 1 6 2.0 O=c1[nH]cc(c(=O)n1CCCN1CCN(CC1)c1ccccc1OCC(F)(F)F)C 10369480
7381 10160 9 None -58 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 7 1 6 2.0 O=c1[nH]cc(c(=O)n1CCCN1CCN(CC1)c1ccccc1OCC(F)(F)F)C 32608144
CHEMBL56331 10160 9 None -58 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 7 1 6 2.0 O=c1[nH]cc(c(=O)n1CCCN1CCN(CC1)c1ccccc1OCC(F)(F)F)C 10369480
CHEMBL56331 10160 9 None -58 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 426 7 1 6 2.0 O=c1[nH]cc(c(=O)n1CCCN1CCN(CC1)c1ccccc1OCC(F)(F)F)C 32608144
4151 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 32608144
4151 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 7651358
493 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 32608144
493 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 7651358
5312125 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 32608144
5312125 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 7651358
CHEMBL24778 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 32608144
CHEMBL24778 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 7651358
DB06207 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 32608144
DB06207 10379 89 None -33 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 495 13 3 6 3.1 OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N 7651358
5268 10428 40 None -39 18 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 11459121
5268 10428 40 None -39 18 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 32608144
53 10428 40 None -39 18 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 11459121
53 10428 40 None -39 18 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 32608144
CHEMBL300555 10428 40 None -39 18 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 11459121
CHEMBL300555 10428 40 None -39 18 Human 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 379 3 1 5 2.3 O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1 32608144
115 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10812954
115 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 32608144
2092 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10812954
2092 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 32608144
7109 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10812954
7109 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 32608144
CHEMBL709 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10812954
CHEMBL709 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 32608144
DB00346 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 10812954
DB00346 7131 71 None -1 7 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 389 8 3 7 2.0 COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C 32608144
3584 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 32608144
3584 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 9379432
5401 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 32608144
5401 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 9379432
7302 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 32608144
7302 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 9379432
CHEMBL611 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 32608144
CHEMBL611 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 9379432
DB01162 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 32608144
DB01162 10549 64 None -1 14 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1 9379432
3033538 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 32608144
7155 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 32608144
781 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 32608144
CHEMBL1201216 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 32608144
DB00298 8101 39 None 1 9 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 325 4 0 5 2.3 Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2 32608144
2136 9869 30 None 3 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 32608144
4768 9869 30 None 3 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 32608144
7268 9869 30 None 3 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 32608144
CHEMBL753 9869 30 None 3 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 32608144
DB00925 9869 30 None 3 6 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 303 8 0 2 4.2 ClCCN(C(COc1ccccc1)C)Cc1ccccc1 32608144
3157 8252 71 None -1 12 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 32608144
7170 8252 71 None -1 12 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 32608144
954 8252 71 None -1 12 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 32608144
CHEMBL707 8252 71 None -1 12 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 32608144
DB00590 8252 71 None -1 12 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 32608144
4209 9937 75 None 1 33 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
4893 9937 75 None 1 33 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
503 9937 75 None 1 33 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
5385 9937 75 None 1 33 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
CHEMBL2 9937 75 None 1 33 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
DB00457 9937 75 None 1 33 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 11354357
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 11459121
2419 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 32608144
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 11354357
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 11459121
9 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 32608144
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 11354357
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 11459121
CHEMBL13647 7482 28 None -1 11 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 32608144
499 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 32608144
499 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 7651358
499 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 9249248
5685 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 32608144
5685 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 7651358
5685 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 9249248
CHEMBL25554 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 32608144
CHEMBL25554 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 7651358
CHEMBL25554 10849 18 None -1 14 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC 9249248
132266 8061 12 None -5 9 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 32608144
132266 8061 12 None -5 9 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 8917649
486 8061 12 None -5 9 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 32608144
486 8061 12 None -5 9 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 8917649
CHEMBL423294 8061 12 None -5 9 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 32608144
CHEMBL423294 8061 12 None -5 9 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 8917649
13156 10220 0 None 416 3 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 6 2 5 2.9 FC1=C(OCCN[C@H]2CCS(C3=CC=C(C=C23)NC)(=O)=O)C=C(C=C1)F 28800452
145946376 10220 0 None 416 3 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 6 2 5 2.9 FC1=C(OCCN[C@H]2CCS(C3=CC=C(C=C23)NC)(=O)=O)C=C(C=C1)F 28800452
CHEMBL4299993 10220 0 None 416 3 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 382 6 2 5 2.9 FC1=C(OCCN[C@H]2CCS(C3=CC=C(C=C23)NC)(=O)=O)C=C(C=C1)F 28800452
4209 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10369480
4209 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
4209 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7651358
4209 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 9249248
4893 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10369480
4893 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
4893 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7651358
4893 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 9249248
503 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10369480
503 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
503 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7651358
503 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 9249248
5385 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10369480
5385 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
5385 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7651358
5385 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 9249248
CHEMBL2 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10369480
CHEMBL2 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
CHEMBL2 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7651358
CHEMBL2 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 9249248
DB00457 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 10369480
DB00457 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 32608144
DB00457 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 7651358
DB00457 9937 75 None 1 33 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 9249248
129211 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10369480
129211 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 32608144
129211 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 7651358
129211 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 9249248
2562 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10369480
2562 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 32608144
2562 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 7651358
2562 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 9249248
488 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10369480
488 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 32608144
488 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 7651358
488 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 9249248
CHEMBL836 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10369480
CHEMBL836 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 32608144
CHEMBL836 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 7651358
CHEMBL836 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 9249248
DB00706 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 10369480
DB00706 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 32608144
DB00706 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 7651358
DB00706 10521 78 None -1 16 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 11 2 6 2.3 CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C 9249248
37 7565 60 None -2 17 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
460 7565 60 None -2 17 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
54746 7565 60 None -2 17 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
CHEMBL1201087 7565 60 None -2 17 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
DB00248 7565 60 None -2 17 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C None
2601 10552 33 None -5 21 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
443951 10552 33 None -5 21 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
56 10552 33 None -5 21 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
CHEMBL73151 10552 33 None -5 21 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
DB13399 10552 33 None -5 21 Human 8.1 pKi None 8.1 Binding
NoneNone
Drug Central 340 3 2 2 2.9 CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC None
15010 7185 0 None - 1 Rat 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 5 3 4 0.3 CNCC(c1cccc(c1)NS(=O)(=O)C)O 7969082
155 7185 0 None - 1 Rat 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 5 3 4 0.3 CNCC(c1cccc(c1)NS(=O)(=O)C)O 7969082
514 7185 0 None - 1 Rat 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 5 3 4 0.3 CNCC(c1cccc(c1)NS(=O)(=O)C)O 7969082
CHEMBL146408 7185 0 None - 1 Rat 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 244 5 3 4 0.3 CNCC(c1cccc(c1)NS(=O)(=O)C)O 7969082
1753 9282 28 None 1 5 Rat 4.5 pKi None 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7969082
483 9282 28 None 1 5 Rat 4.5 pKi None 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7969082
6082 9282 28 None 1 5 Rat 4.5 pKi None 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7969082
CHEMBL524 9282 28 None 1 5 Rat 4.5 pKi None 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7969082
DB00723 9282 28 None 1 5 Rat 4.5 pKi None 4.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 211 4 2 4 1.1 COc1ccc(c(c1)C(C(N)C)O)OC 7969082
481 9667 7 None -4 3 Human 5.4 pKi None 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O 8719417
9838763 9667 7 None -4 3 Human 5.4 pKi None 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O 8719417
CHEMBL72958 9667 7 None -4 3 Human 5.4 pKi None 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O 8719417
121925 8807 0 None - 1 Rat 5.5 pKi None 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 215 1 2 5 0.9 Cn1nc2c(c1)c(ccc2)NC1=NCCN1 7969082
512 8807 0 None - 1 Rat 5.5 pKi None 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 215 1 2 5 0.9 Cn1nc2c(c1)c(ccc2)NC1=NCCN1 7969082
CHEMBL358373 8807 0 None - 1 Rat 5.5 pKi None 5.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 215 1 2 5 0.9 Cn1nc2c(c1)c(ccc2)NC1=NCCN1 7969082
1862 6949 18 None 1 7 Rat 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 187 2 4 4 0.2 NCC(c1cc(O)c(cc1F)O)O 7969082
510 6949 18 None 1 7 Rat 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 187 2 4 4 0.2 NCC(c1cc(O)c(cc1F)O)O 7969082
CHEMBL281232 6949 18 None 1 7 Rat 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 187 2 4 4 0.2 NCC(c1cc(O)c(cc1F)O)O 7969082
128805 10392 0 None - 1 Rat 6.1 pKi None 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 223 2 1 3 2.2 COc1ccc(c2c1CC(N)CC2)SC 7969082
511 10392 0 None - 1 Rat 6.1 pKi None 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 223 2 1 3 2.2 COc1ccc(c2c1CC(N)CC2)SC 7969082
CHEMBL280395 10392 0 None - 1 Rat 6.1 pKi None 6.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 223 2 1 3 2.2 COc1ccc(c2c1CC(N)CC2)SC 7969082
124 9755 47 None -338 32 Rat 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7969082
2032 9755 47 None -338 32 Rat 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7969082
4636 9755 47 None -338 32 Rat 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7969082
CHEMBL762 9755 47 None -338 32 Rat 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7969082
DB00935 9755 47 None -338 32 Rat 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C 7969082
2765 7730 19 None -3 9 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 7969082
515 7730 19 None -3 9 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 7969082
CHEMBL13852 7730 19 None -3 9 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 7969082
DB09202 7730 19 None -3 9 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1 7969082
2803 7742 58 None -2 19 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 7969082
516 7742 58 None -2 19 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 7969082
704 7742 58 None -2 19 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 7969082
CHEMBL134 7742 58 None -2 19 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 7969082
DB00575 7742 58 None -2 19 Rat 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl 7969082
277 8083 62 None -42 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 11459121
2913 8083 62 None -42 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 11459121
765 8083 62 None -42 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 11459121
CHEMBL516 8083 62 None -42 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 11459121
DB00434 8083 62 None -42 50 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1 11459121
518 10384 1 None -5 6 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl 7568329
9839317 10384 1 None -5 6 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl 7568329
CHEMBL123138 10384 1 None -5 6 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl 7568329
497 10138 8 None -61 3 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 444 7 1 6 2.1 Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C 10369480
9872515 10138 8 None -61 3 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 444 7 1 6 2.1 Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C 10369480
CHEMBL24777 10138 8 None -61 3 Human 7.2 pKi None 7.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 444 7 1 6 2.1 Fc1ccc(c(c1)OCC(F)(F)F)N1CCN(CC1)CCCn1c(=O)[nH]cc(c1=O)C 10369480
2389 10104 118 None -24 66 Human 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 11459121
5073 10104 118 None -24 66 Human 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 11459121
96 10104 118 None -24 66 Human 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 11459121
CHEMBL85 10104 118 None -24 66 Human 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 11459121
DB00734 10104 118 None -24 66 Human 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 11459121
135 9310 43 None -10 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 11459121
1796 9310 43 None -10 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 11459121
4184 9310 43 None -10 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 11459121
CHEMBL6437 9310 43 None -10 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 11459121
DB06148 9310 43 None -10 56 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 11459121
132266 8061 12 None -20 9 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 8917649
486 8061 12 None -20 9 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 8917649
CHEMBL423294 8061 12 None -20 9 Rat 7.6 pKi None 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 437 4 1 8 3.1 COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1 8917649
135398737 7745 93 None -2 90 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11459121
38 7745 93 None -2 90 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11459121
722 7745 93 None -2 90 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11459121
CHEMBL42 7745 93 None -2 90 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11459121
DB00363 7745 93 None -2 90 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 11459121
1524 8962 96 None -8 51 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11459121
197 8962 96 None -8 51 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11459121
3822 8962 96 None -8 51 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11459121
88 8962 96 None -8 51 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11459121
CHEMBL51 8962 96 None -8 51 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11459121
DB12465 8962 96 None -8 51 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 5 2.4 Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 11459121
5074 10105 80 None -27 30 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 11459121
97 10105 80 None -27 30 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 11459121
CHEMBL267777 10105 80 None -27 30 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 11459121
DB12693 10105 80 None -27 30 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 477 5 0 5 5.5 Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F 11459121
148842 10718 27 None -8 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 511 8 1 6 4.7 COc1ccccc1N1CCN(CC1)CCCNC(=O)c1cccc2c1oc(c1ccccc1)c(c2=O)C 9249248
496 10718 27 None -8 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 511 8 1 6 4.7 COc1ccccc1N1CCN(CC1)CCCNC(=O)c1cccc2c1oc(c1ccccc1)c(c2=O)C 9249248
CHEMBL278865 10718 27 None -8 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 511 8 1 6 4.7 COc1ccccc1N1CCN(CC1)CCCNC(=O)c1cccc2c1oc(c1ccccc1)c(c2=O)C 9249248
2470 10425 50 None -309 58 Human 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11459121
3300 10425 50 None -309 58 Human 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11459121
5265 10425 50 None -309 58 Human 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11459121
99 10425 50 None -309 58 Human 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11459121
CHEMBL267930 10425 50 None -309 58 Human 8.1 pKi None 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 11459121
2419 7482 28 None -3 11 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 11354357
9 7482 28 None -3 11 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 11354357
CHEMBL13647 7482 28 None -3 11 Rat 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 385 5 0 5 2.5 COc1ccccc1N1CCN(CC1)CCN1C(=O)CC2(CC1=O)CCCC2 11354357
4431 9506 25 None -1 12 Human 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 11459121
73 9506 25 None -1 12 Human 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 11459121
CHEMBL8618 9506 25 None -1 12 Human 9.2 pKi None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 11459121
491 6980 9 None -3 12 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 11354357
9891167 6980 9 None -3 12 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 11354357
CHEMBL13856 6980 9 None -3 12 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 11354357
490 6979 8 None -2 12 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 11354357
9890547 6979 8 None -2 12 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 11354357
CHEMBL268758 6979 8 None -2 12 Human 9.6 pKi None 9.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 11354357
490 6979 8 None 2 12 Rat 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 11354357
9890547 6979 8 None 2 12 Rat 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 11354357
CHEMBL268758 6979 8 None 2 12 Rat 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 462 6 1 7 3.2 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1 11354357
491 6980 9 None 3 12 Rat 9.8 pKi None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 11354357
9891167 6980 9 None 3 12 Rat 9.8 pKi None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 11354357
CHEMBL13856 6980 9 None 3 12 Rat 9.8 pKi None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 476 6 1 7 3.6 COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C 11354357