Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 16133225 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 172198 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 2504 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 45266664 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 5272 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| CHEMBL408403 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| DB11842 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 16133225 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 172198 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 2504 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 45266664 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 5272 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| CHEMBL408403 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| DB11842 | 419 | 52 | None | -5 | 4 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | ||||
| 127030943 | 139195 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787243 | 139195 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787375 | 139195 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787700 | 139195 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 127030943 | 139195 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787243 | 139195 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787375 | 139195 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787700 | 139195 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 16133225 | 419 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 172198 | 419 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 2504 | 419 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 45266664 | 419 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 5272 | 419 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL408403 | 419 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| DB11842 | 419 | 52 | None | -6 | 4 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 127029976 | 139217 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3786145 | 139217 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787767 | 139217 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 127029976 | 139217 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3786145 | 139217 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787767 | 139217 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 155564502 | 175260 | 0 | None | 2 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| CHEMBL4572408 | 175260 | 0 | None | 2 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| 11943 | 3875 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 145925549 | 3875 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL4438122 | 3875 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 155558059 | 174683 | 0 | None | -5 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4559239 | 174683 | 0 | None | -5 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| 155541440 | 173019 | 0 | None | -1 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| CHEMBL4518530 | 173019 | 0 | None | -1 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| 155541295 | 173011 | 0 | None | 4 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| CHEMBL4518318 | 173011 | 0 | None | 4 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| 155540639 | 172933 | 0 | None | -1 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4516768 | 172933 | 0 | None | -1 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL2028943 | 209135 | 0 | None | -1 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | ||||
| 155553930 | 175441 | 0 | None | -1 | 2 | Rat | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4576650 | 175441 | 0 | None | -1 | 2 | Rat | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155540033 | 172890 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| CHEMBL4515768 | 172890 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| 127029977 | 139218 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3786986 | 139218 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787768 | 139218 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 127029977 | 139218 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3786986 | 139218 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787768 | 139218 | 0 | None | - | 1 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 127031545 | 139196 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787379 | 139196 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787701 | 139196 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 127031545 | 139196 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787379 | 139196 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787701 | 139196 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 16133225 | 419 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 172198 | 419 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 2504 | 419 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 45266664 | 419 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 5272 | 419 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL408403 | 419 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| DB11842 | 419 | 52 | None | -5 | 4 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 155541440 | 173019 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| CHEMBL4518530 | 173019 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| 10533900 | 175969 | 8 | None | 10 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| CHEMBL4588454 | 175969 | 8 | None | 10 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| 155556507 | 174486 | 0 | None | 2 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4554466 | 174486 | 0 | None | 2 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155563538 | 175300 | 0 | None | -1 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | ||
| CHEMBL4573250 | 175300 | 0 | None | -1 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | ||
| 155559104 | 174806 | 0 | None | 2 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||
| CHEMBL4562270 | 174806 | 0 | None | 2 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||
| 155554865 | 174354 | 0 | None | 2 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| CHEMBL4551317 | 174354 | 0 | None | 2 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| 155540328 | 172901 | 0 | None | -3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| CHEMBL4516066 | 172901 | 0 | None | -3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| 155553479 | 174178 | 0 | None | 3 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| CHEMBL4547423 | 174178 | 0 | None | 3 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| 155558003 | 174693 | 0 | None | 1 | 2 | Rat | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4559421 | 174693 | 0 | None | 1 | 2 | Rat | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155547428 | 173615 | 0 | None | -22 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4533618 | 173615 | 0 | None | -22 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155566196 | 175746 | 0 | None | -5 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4583284 | 175746 | 0 | None | -5 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155558428 | 174729 | 0 | None | 1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | ||
| CHEMBL4560224 | 174729 | 0 | None | 1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | ||
| 11944 | 3876 | 0 | None | 4 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 155552190 | 3876 | 0 | None | 4 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL4544228 | 3876 | 0 | None | 4 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | None | None | None | None | nan | ||||
| CHEMBL77838 | 215878 | 5 | None | -1 | 2 | Rat | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O | nan | ||||
| 155552475 | 174052 | 0 | None | 9 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4543860 | 174052 | 0 | None | 9 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| 155542907 | 173177 | 0 | None | 3 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | ||
| CHEMBL4522038 | 173177 | 0 | None | 3 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | ||
| CHEMBL2028943 | 209135 | 0 | None | 1 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | ||||
| 155552475 | 174052 | 0 | None | -9 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4543860 | 174052 | 0 | None | -9 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| 155556530 | 174511 | 0 | None | 2 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4555119 | 174511 | 0 | None | 2 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | ||
| 155561376 | 175675 | 0 | None | 12 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | ||
| CHEMBL4581718 | 175675 | 0 | None | 12 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | ||
| 155541125 | 172965 | 0 | None | 6 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | ||
| CHEMBL4517561 | 172965 | 0 | None | 6 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | ||
| 24892627 | 55653 | 5 | None | -5 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 548 | 8 | 0 | 6 | 5.0 | Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 | nan | ||
| CHEMBL1460676 | 55653 | 5 | None | -5 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 548 | 8 | 0 | 6 | 5.0 | Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 | nan | ||
| CHEMBL1621632 | 55653 | 5 | None | -5 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 548 | 8 | 0 | 6 | 5.0 | Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 | nan | ||
| 155558059 | 174683 | 0 | None | 5 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4559239 | 174683 | 0 | None | 5 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL938 | 215907 | 28 | None | -10 | 4 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | ||||
| CHEMBL312754 | 211110 | 18 | None | 1 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||||
| 154573825 | 175989 | 9 | None | 8 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4588946 | 175989 | 9 | None | 8 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| 155560463 | 175040 | 0 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | ||
| CHEMBL4567667 | 175040 | 0 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | ||
| 155553003 | 174076 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| CHEMBL4544308 | 174076 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| 10533900 | 175969 | 8 | None | -10 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| CHEMBL4588454 | 175969 | 8 | None | -10 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| CHEMBL2392353 | 210414 | 6 | None | -50 | 3 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | None | None | None | None | nan | ||||
| 155553098 | 174110 | 0 | None | 22 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| CHEMBL4545153 | 174110 | 0 | None | 22 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| 1588251 | 59277 | 10 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 436 | 4 | 0 | 5 | 5.8 | CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O | nan | ||
| CHEMBL1704271 | 59277 | 10 | None | - | 1 | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 436 | 4 | 0 | 5 | 5.8 | CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O | nan | ||
| 155540328 | 172901 | 0 | None | 3 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| CHEMBL4516066 | 172901 | 0 | None | 3 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| 155540033 | 172890 | 0 | None | 2 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| CHEMBL4515768 | 172890 | 0 | None | 2 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| 155539838 | 172895 | 0 | None | 1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4515848 | 172895 | 0 | None | 1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL2370909 | 209948 | 0 | None | 7 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | ||||
| 155558784 | 174776 | 0 | None | -2 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| CHEMBL4561366 | 174776 | 0 | None | -2 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| 154573825 | 175989 | 9 | None | -8 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4588946 | 175989 | 9 | None | -8 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| 155553003 | 174076 | 0 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| CHEMBL4544308 | 174076 | 0 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| 3025727 | 184080 | 10 | None | 10000 | 2 | Rabbit | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL48242 | 184080 | 10 | None | 10000 | 2 | Rabbit | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971704 | 112385 | 0 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL329616 | 112385 | 0 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 133031 | 100859 | 21 | None | 1 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
| CHEMBL293511 | 100859 | 21 | None | 1 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
| 9892554 | 100194 | 6 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 510 | 9 | 1 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL288246 | 100194 | 6 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 510 | 9 | 1 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971715 | 168236 | 0 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 492 | 10 | 2 | 6 | 5.4 | CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL433646 | 168236 | 0 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 492 | 10 | 2 | 6 | 5.4 | CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971716 | 14524 | 0 | None | - | 1 | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 506 | 11 | 2 | 6 | 5.6 | CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120199 | 14524 | 0 | None | - | 1 | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 506 | 11 | 2 | 6 | 5.6 | CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971706 | 207209 | 0 | None | - | 1 | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL92654 | 207209 | 0 | None | - | 1 | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 183134 | 204844 | 17 | None | -4 | 7 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm1013693 | ||
| CHEMBL7550 | 204844 | 17 | None | -4 | 7 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm1013693 | ||
| 14971698 | 207293 | 0 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93226 | 207293 | 0 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 9827346 | 99737 | 4 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL284918 | 99737 | 4 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL34866 | 99737 | 4 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/j.bmc.2010.10.043 | ||
| 9870652 | 70892 | 75 | None | 15 | 2 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951143 | 70892 | 75 | None | 15 | 2 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971720 | 114822 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL334145 | 114822 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971720 | 114822 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL334145 | 114822 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971705 | 206749 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 492 | 9 | 2 | 6 | 5.7 | CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL90011 | 206749 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 492 | 9 | 2 | 6 | 5.7 | CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10325927 | 206886 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 580 | 9 | 2 | 6 | 7.3 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL90774 | 206886 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 580 | 9 | 2 | 6 | 7.3 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971714 | 99190 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 484 | 9 | 2 | 6 | 4.9 | CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL281386 | 99190 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 484 | 9 | 2 | 6 | 4.9 | CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 183134 | 204844 | 17 | None | -2 | 7 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00078a013 | ||
| 183134 | 204844 | 17 | None | -2 | 7 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL7550 | 204844 | 17 | None | -2 | 7 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00078a013 | ||
| CHEMBL7550 | 204844 | 17 | None | -2 | 7 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00078a014 | ||
| 14971639 | 114132 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL332897 | 114132 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971639 | 114132 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL332897 | 114132 | 0 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971702 | 207179 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL92472 | 207179 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971710 | 207398 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 554 | 10 | 2 | 6 | 7.0 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93886 | 207398 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 554 | 10 | 2 | 6 | 7.0 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971717 | 14582 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.0 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120457 | 14582 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.0 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10369813 | 116980 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.3 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL338740 | 116980 | 0 | None | - | 1 | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.3 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 142534045 | 166478 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 543 | 9 | 1 | 7 | 4.9 | CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4278280 | 166478 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 543 | 9 | 1 | 7 | 4.9 | CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956763 | 163397 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL419483 | 163397 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971701 | 207419 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL94002 | 207419 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971708 | 114594 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 508 | 10 | 2 | 7 | 5.4 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL333800 | 114594 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 508 | 10 | 2 | 7 | 5.4 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10393717 | 116099 | 0 | None | 524 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL335722 | 116099 | 0 | None | 524 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| 9914666 | 116670 | 0 | None | 3388 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL337086 | 116670 | 0 | None | 3388 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 14956739 | 206302 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87074 | 206302 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 192567 | 116652 | 6 | None | 223 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL337007 | 116652 | 6 | None | 223 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10140613 | 106096 | 0 | None | 3 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313371 | 106096 | 0 | None | 3 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956772 | 105947 | 0 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL312913 | 105947 | 0 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 192345 | 26236 | 6 | None | 12022 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL135775 | 26236 | 6 | None | 12022 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| 10326140 | 116651 | 0 | None | 2884 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL337006 | 116651 | 0 | None | 2884 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| 9807766 | 70884 | 0 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 555 | 9 | 1 | 8 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951136 | 70884 | 0 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 555 | 9 | 1 | 8 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 60770 | 169499 | 17 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 506 | 8 | 2 | 6 | 5.1 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL443269 | 169499 | 17 | None | - | 1 | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 506 | 8 | 2 | 6 | 5.1 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 142534141 | 167177 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4291216 | 167177 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956757 | 67593 | 0 | None | 831 | 2 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL19018 | 67593 | 0 | None | 831 | 2 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971700 | 207457 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL94221 | 207457 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 9871638 | 70893 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 529 | 11 | 1 | 7 | 5.0 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951144 | 70893 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 529 | 11 | 1 | 7 | 5.0 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 44320012 | 167923 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL431411 | 167923 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 155542482 | 173127 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 487 | 9 | 1 | 6 | 5.5 | CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| CHEMBL4520827 | 173127 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 487 | 9 | 1 | 6 | 5.5 | CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| 44213341 | 70877 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 511 | 9 | 1 | 7 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951129 | 70877 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 511 | 9 | 1 | 7 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 137532858 | 167090 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 517 | 9 | 1 | 7 | 4.4 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4289788 | 167090 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 517 | 9 | 1 | 7 | 4.4 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14971719 | 114792 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 470 | 8 | 2 | 6 | 4.5 | CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL333978 | 114792 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 470 | 8 | 2 | 6 | 4.5 | CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971711 | 16554 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 479 | 9 | 2 | 7 | 4.7 | CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL123767 | 16554 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 479 | 9 | 2 | 7 | 4.7 | CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971707 | 207336 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 523 | 10 | 2 | 8 | 5.3 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93547 | 207336 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 523 | 10 | 2 | 8 | 5.3 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44213349 | 70883 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 9 | 1 | 8 | 3.2 | CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951135 | 70883 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 9 | 1 | 8 | 3.2 | CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 20081627 | 92170 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL24224 | 92170 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/j.bmc.2010.10.043 | ||
| 145981239 | 166609 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 9 | 1 | 7 | 5.7 | CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4280574 | 166609 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 9 | 1 | 7 | 5.7 | CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 131654 | 206403 | 12 | None | 1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87778 | 206403 | 12 | None | 1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956781 | 206173 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86314 | 206173 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9845644 | 206433 | 0 | None | 5 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87964 | 206433 | 0 | None | 5 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 10095589 | 115519 | 0 | None | 851 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL335289 | 115519 | 0 | None | 851 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| 19939399 | 106164 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 609 | 11 | 2 | 10 | 5.2 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313696 | 106164 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 609 | 11 | 2 | 10 | 5.2 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10222835 | 206145 | 0 | None | 2 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86084 | 206145 | 0 | None | 2 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 142533975 | 167048 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4288964 | 167048 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 44348352 | 16528 | 0 | None | 1 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL123713 | 16528 | 0 | None | 1 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| 14971675 | 206969 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL91287 | 206969 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10048220 | 26189 | 0 | None | 109 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL135704 | 26189 | 0 | None | 109 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| 14956760 | 165500 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL424053 | 165500 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956777 | 206329 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 415 | 8 | 1 | 7 | 3.6 | CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87276 | 206329 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 415 | 8 | 1 | 7 | 3.6 | CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 164611301 | 185018 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4854916 | 185018 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| 1240113 | 29470 | 7 | None | -3 | 3 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 265 | 3 | 0 | 2 | 4.8 | Cc1cccc(CSc2cccc3cccnc23)c1 | nan | ||
| CHEMBL1384550 | 29470 | 7 | None | -3 | 3 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 265 | 3 | 0 | 2 | 4.8 | Cc1cccc(CSc2cccc3cccnc23)c1 | nan | ||
| 164622816 | 185874 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4868159 | 185874 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| 5411796 | 71927 | 9 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 335 | 4 | 1 | 3 | 3.9 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl | nan | ||
| CHEMBL1972216 | 71927 | 9 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 335 | 4 | 1 | 3 | 3.9 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl | nan | ||
| 5740287 | 40195 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 394 | 6 | 0 | 7 | 4.3 | COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1480264 | 40195 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 394 | 6 | 0 | 7 | 4.3 | COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 | nan | ||
| 5738419 | 48454 | 14 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 2 | 1 | 3 | 4.2 | Oc1cccc2ccc(/C=C/c3cccs3)nc12 | nan | ||
| CHEMBL1555793 | 48454 | 14 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 2 | 1 | 3 | 4.2 | Oc1cccc2ccc(/C=C/c3cccs3)nc12 | nan | ||
| 659124 | 38437 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 406 | 7 | 1 | 7 | 4.4 | CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 | nan | ||
| CHEMBL1463829 | 38437 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 406 | 7 | 1 | 7 | 4.4 | CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 | nan | ||
| 1183382 | 23505 | 15 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 367 | 5 | 0 | 7 | 3.3 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O | nan | ||
| CHEMBL1333737 | 23505 | 15 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 367 | 5 | 0 | 7 | 3.3 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O | nan | ||
| 1334532 | 36926 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 365 | 2 | 3 | 4 | 3.0 | Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 | nan | ||
| CHEMBL1451169 | 36926 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 365 | 2 | 3 | 4 | 3.0 | Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 | nan | ||
| 10257526 | 112372 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL329541 | 112372 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 5952109 | 72046 | 7 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 389 | 4 | 1 | 5 | 5.6 | CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 | nan | ||
| CHEMBL1976317 | 72046 | 7 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 389 | 4 | 1 | 5 | 5.6 | CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 | nan | ||
| 2236648 | 28705 | 11 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 355 | 2 | 3 | 3 | 3.0 | CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| CHEMBL1377849 | 28705 | 11 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 355 | 2 | 3 | 3 | 3.0 | CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| 6154033 | 108481 | 5 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 4 | 1 | 3 | 3.4 | O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 | nan | ||
| CHEMBL3199403 | 108481 | 5 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 4 | 1 | 3 | 3.4 | O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 | nan | ||
| 4116022 | 50995 | 6 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 368 | 10 | 1 | 9 | 3.4 | CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 | nan | ||
| CHEMBL1578324 | 50995 | 6 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 368 | 10 | 1 | 9 | 3.4 | CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 | nan | ||
| 19939367 | 105950 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL312921 | 105950 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956804 | 105999 | 0 | None | 1 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313222 | 105999 | 0 | None | 1 | 2 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956792 | 106766 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314447 | 106766 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956754 | 157385 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL407827 | 157385 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956787 | 206347 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 461 | 9 | 1 | 9 | 3.0 | CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87363 | 206347 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 461 | 9 | 1 | 9 | 3.0 | CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44373246 | 168267 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1021/jm9504722 | ||
| CHEMBL433895 | 168267 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1021/jm9504722 | ||
| 14956796 | 205799 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83182 | 205799 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10094520 | 24758 | 0 | None | 11 | 2 | Rabbit | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | ||
| CHEMBL134433 | 24758 | 0 | None | 11 | 2 | Rabbit | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | ||
| 3504072 | 33630 | 12 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 299 | 2 | 2 | 3 | 2.1 | O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 | nan | ||
| CHEMBL1421427 | 33630 | 12 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 299 | 2 | 2 | 3 | 2.1 | O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 | nan | ||
| 869765 | 38588 | 8 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 322 | 5 | 2 | 6 | 3.1 | COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC | nan | ||
| CHEMBL1464917 | 38588 | 8 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 322 | 5 | 2 | 6 | 3.1 | COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC | nan | ||
| 16446215 | 47607 | 9 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 467 | 7 | 1 | 6 | 4.3 | Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 | nan | ||
| CHEMBL1546607 | 47607 | 9 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 467 | 7 | 1 | 6 | 4.3 | Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 | nan | ||
| 5295671 | 35516 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 314 | 2 | 0 | 6 | 2.1 | CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| CHEMBL1438779 | 35516 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 314 | 2 | 0 | 6 | 2.1 | CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| 1653161 | 40325 | 13 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 3 | 3 | 5 | 1.2 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 | nan | ||
| CHEMBL1481281 | 40325 | 13 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 3 | 3 | 5 | 1.2 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 | nan | ||
| 14956759 | 206102 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85704 | 206102 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 5335659 | 108463 | 7 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 | nan | ||
| CHEMBL3199216 | 108463 | 7 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 | nan | ||
| 16446684 | 42995 | 9 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 405 | 5 | 1 | 5 | 3.5 | O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl | nan | ||
| CHEMBL1504077 | 42995 | 9 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 405 | 5 | 1 | 5 | 3.5 | O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl | nan | ||
| 2426231 | 38123 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 394 | 3 | 3 | 3 | 5.3 | Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| CHEMBL1461119 | 38123 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 394 | 3 | 3 | 3 | 5.3 | Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| 53319274 | 57600 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1668000 | 57600 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| 10027714 | 115437 | 0 | None | 398 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL335066 | 115437 | 0 | None | 398 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 14956793 | 206308 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87129 | 206308 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956791 | 206341 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 459 | 8 | 2 | 8 | 3.4 | CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87341 | 206341 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 459 | 8 | 2 | 8 | 3.4 | CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956798 | 206409 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87798 | 206409 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14951059 | 206429 | 0 | None | -1 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87942 | 206429 | 0 | None | -1 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 11744670 | 115254 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 5 | 0 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 | 10.1021/jm00078a013 | ||
| CHEMBL334775 | 115254 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 5 | 0 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 | 10.1021/jm00078a013 | ||
| 14956742 | 206328 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87275 | 206328 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 5187118 | 51862 | 6 | None | -5 | 4 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 338 | 3 | 1 | 3 | 4.8 | Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 | nan | ||
| CHEMBL1585527 | 51862 | 6 | None | -5 | 4 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 338 | 3 | 1 | 3 | 4.8 | Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 | nan | ||
| 2313746 | 52120 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl | nan | ||
| CHEMBL1587672 | 52120 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl | nan | ||
| 6917582 | 45673 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| CHEMBL1529805 | 45673 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| 665535 | 44994 | 6 | None | -1 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 425 | 7 | 1 | 9 | 1.8 | COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 | nan | ||
| CHEMBL1523699 | 44994 | 6 | None | -1 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 425 | 7 | 1 | 9 | 1.8 | COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 | nan | ||
| 2812568 | 37207 | 5 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 286 | 3 | 2 | 3 | 3.8 | O=C(NNc1ccc(Cl)cc1)c1sccc1Cl | nan | ||
| CHEMBL1453309 | 37207 | 5 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 286 | 3 | 2 | 3 | 3.8 | O=C(NNc1ccc(Cl)cc1)c1sccc1Cl | nan | ||
| 921731 | 52176 | 7 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 321 | 5 | 0 | 7 | 2.1 | O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1588194 | 52176 | 7 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 321 | 5 | 0 | 7 | 2.1 | O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 6173110 | 108160 | 4 | None | 1 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 331 | 5 | 1 | 4 | 3.3 | COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 | nan | ||
| CHEMBL3196139 | 108160 | 4 | None | 1 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 331 | 5 | 1 | 4 | 3.3 | COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 | nan | ||
| 2351493 | 49785 | 2 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 301 | 4 | 1 | 3 | 3.3 | O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 | nan | ||
| CHEMBL1567294 | 49785 | 2 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 301 | 4 | 1 | 3 | 3.3 | O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 | nan | ||
| 11467216 | 122602 | 0 | None | - | 1 | Rabbit | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 567 | 15 | 1 | 10 | 5.2 | CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| CHEMBL360220 | 122602 | 0 | None | - | 1 | Rabbit | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 567 | 15 | 1 | 10 | 5.2 | CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| 135457059 | 51015 | 23 | None | -2 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 1 | 5 | 4.2 | Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 | nan | ||
| CHEMBL1578482 | 51015 | 23 | None | -2 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 1 | 5 | 4.2 | Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 | nan | ||
| 2303647 | 28426 | 10 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 262 | 3 | 2 | 4 | 3.1 | NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 | nan | ||
| CHEMBL1375248 | 28426 | 10 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 262 | 3 | 2 | 4 | 3.1 | NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 | nan | ||
| 11328757 | 205967 | 0 | None | -1 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL84573 | 205967 | 0 | None | -1 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 9896251 | 98773 | 0 | None | 1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmc.2012.06.011 | ||
| CHEMBL278176 | 98773 | 0 | None | 1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmc.2012.06.011 | ||
| 9958963 | 207232 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL92821 | 207232 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971680 | 207371 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 520 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93735 | 207371 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 520 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 57391456 | 70891 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 569 | 10 | 1 | 8 | 4.4 | CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951142 | 70891 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 569 | 10 | 1 | 8 | 4.4 | CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971687 | 14813 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120716 | 14813 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956812 | 106672 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 463 | 8 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314333 | 106672 | 0 | None | - | 1 | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 463 | 8 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 793621 | 26580 | 8 | None | 1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 281 | 1 | 1 | 5 | 3.3 | CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 | nan | ||
| CHEMBL1361034 | 26580 | 8 | None | 1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 281 | 1 | 1 | 5 | 3.3 | CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 | nan | ||
| 2420694 | 33050 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.8 | Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 | nan | ||
| CHEMBL1416497 | 33050 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.8 | Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 | nan | ||
| 1477595 | 44659 | 29 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 264 | 3 | 0 | 5 | 1.8 | O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 | nan | ||
| CHEMBL1520753 | 44659 | 29 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 264 | 3 | 0 | 5 | 1.8 | O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 | nan | ||
| 1336836 | 33009 | 10 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 398 | 5 | 0 | 6 | 4.5 | Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 | nan | ||
| CHEMBL1416155 | 33009 | 10 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 398 | 5 | 0 | 6 | 4.5 | Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 | nan | ||
| 135489943 | 107866 | 3 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 387 | 9 | 2 | 5 | 4.0 | CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O | nan | ||
| CHEMBL3192625 | 107866 | 3 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 387 | 9 | 2 | 5 | 4.0 | CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O | nan | ||
| 1139588 | 38361 | 11 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 363 | 5 | 0 | 6 | 3.2 | O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1463168 | 38361 | 11 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 363 | 5 | 0 | 6 | 3.2 | O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 6873170 | 108465 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 249 | 2 | 1 | 3 | 1.2 | S=C(N/N=C/c1ccccc1)N1CCOCC1 | nan | ||
| CHEMBL3199234 | 108465 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 249 | 2 | 1 | 3 | 1.2 | S=C(N/N=C/c1ccccc1)N1CCOCC1 | nan | ||
| 804442 | 53827 | 56 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 289 | 4 | 1 | 2 | 3.7 | O=C(CNc1ccc(Br)cc1)c1ccccc1 | nan | ||
| CHEMBL1604367 | 53827 | 56 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 289 | 4 | 1 | 2 | 3.7 | O=C(CNc1ccc(Br)cc1)c1ccccc1 | nan | ||
| 929469 | 46562 | 9 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 5 | 0 | 7 | 1.4 | O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1537991 | 46562 | 9 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 5 | 0 | 7 | 1.4 | O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 3244543 | 199496 | 25 | None | -3 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 188 | 0 | 2 | 3 | 2.1 | Cc1cc(C)c2ccc(N)nc2c1O | nan | ||
| CHEMBL591834 | 199496 | 25 | None | -3 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 188 | 0 | 2 | 3 | 2.1 | Cc1cc(C)c2ccc(N)nc2c1O | nan | ||
| 43001 | 52785 | 26 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 230 | 1 | 1 | 4 | 2.0 | Nc1c(N2CCCC2)c2ccccc2oc1=O | nan | ||
| CHEMBL1594894 | 52785 | 26 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 230 | 1 | 1 | 4 | 2.0 | Nc1c(N2CCCC2)c2ccccc2oc1=O | nan | ||
| 788616 | 53074 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 269 | 5 | 1 | 4 | 2.8 | COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 | nan | ||
| CHEMBL1597563 | 53074 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 269 | 5 | 1 | 4 | 2.8 | COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 | nan | ||
| 2998385 | 25154 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 381 | 8 | 1 | 6 | 2.7 | CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| CHEMBL1347643 | 25154 | 1 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 381 | 8 | 1 | 6 | 2.7 | CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| 9549748 | 23239 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 1 | 1 | 1 | 4.4 | SC1=NCCc2ccccc2C1c1ccccc1Cl | nan | ||
| CHEMBL1331656 | 23239 | 8 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 1 | 1 | 1 | 4.4 | SC1=NCCc2ccccc2C1c1ccccc1Cl | nan | ||
| 2939261 | 22115 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 3 | 4 | 3.4 | CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| CHEMBL1322052 | 22115 | 6 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 3 | 4 | 3.4 | CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| 14956799 | 106899 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314590 | 106899 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956766 | 106979 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315128 | 106979 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956813 | 206339 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 477 | 9 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87330 | 206339 | 0 | None | - | 1 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 477 | 9 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44211606 | 101213 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 591 | 10 | 1 | 10 | 5.2 | CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295905 | 101213 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 591 | 10 | 1 | 10 | 5.2 | CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 44246747 | 55837 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| CHEMBL1521291 | 55837 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| CHEMBL1623128 | 55837 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| 135501733 | 37060 | 17 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 336 | 3 | 2 | 5 | 2.4 | Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 | nan | ||
| CHEMBL1452116 | 37060 | 17 | None | -1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 336 | 3 | 2 | 5 | 2.4 | Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 | nan | ||
| 2898747 | 36766 | 12 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 418 | 6 | 0 | 7 | 1.8 | O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1449757 | 36766 | 12 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 418 | 6 | 0 | 7 | 1.8 | O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 788619 | 45567 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 | nan | ||
| CHEMBL1528883 | 45567 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 | nan | ||
| 3648468 | 51507 | 8 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 4 | 1 | 3 | 4.6 | O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 | nan | ||
| CHEMBL1582697 | 51507 | 8 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 4 | 1 | 3 | 4.6 | O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 | nan | ||
| 135419079 | 30226 | 7 | None | -1 | 4 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 340 | 2 | 2 | 5 | 4.0 | Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O | nan | ||
| CHEMBL1390716 | 30226 | 7 | None | -1 | 4 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 340 | 2 | 2 | 5 | 4.0 | Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O | nan | ||
| 877472 | 36676 | 8 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 323 | 4 | 1 | 2 | 4.4 | O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 | nan | ||
| CHEMBL1449035 | 36676 | 8 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 323 | 4 | 1 | 2 | 4.4 | O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 | nan | ||
| 902793 | 43213 | 18 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1505893 | 43213 | 18 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| 67903280 | 186202 | 0 | None | 4 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 430 | 8 | 1 | 5 | 4.9 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4872989 | 186202 | 0 | None | 4 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 430 | 8 | 1 | 5 | 4.9 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 44355662 | 26462 | 0 | None | 125 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL135999 | 26462 | 0 | None | 125 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 10004013 | 116693 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 452 | 7 | 1 | 7 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL337217 | 116693 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 452 | 7 | 1 | 7 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 | 10.1021/jm00078a014 | ||
| 14956744 | 206163 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86255 | 206163 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1726745 | 23930 | 11 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 3.4 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl | nan | ||
| CHEMBL1337184 | 23930 | 11 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 3.4 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl | nan | ||
| 5731702 | 186652 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 277 | 3 | 1 | 3 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 | nan | ||
| CHEMBL488140 | 186652 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 277 | 3 | 1 | 3 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 | nan | ||
| 2476054 | 47897 | 3 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 347 | 3 | 3 | 4 | 3.9 | FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 | nan | ||
| CHEMBL1549272 | 47897 | 3 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 347 | 3 | 3 | 4 | 3.9 | FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 | nan | ||
| 2458676 | 31410 | 4 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 6 | 1 | 6 | 2.4 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 | nan | ||
| CHEMBL1402558 | 31410 | 4 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 6 | 1 | 6 | 2.4 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 | nan | ||
| 2221657 | 34515 | 11 | None | -3 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 353 | 2 | 0 | 5 | 3.6 | O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 | nan | ||
| CHEMBL1428950 | 34515 | 11 | None | -3 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 353 | 2 | 0 | 5 | 3.6 | O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 | nan | ||
| 44342039 | 10293 | 0 | None | -21 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL116170 | 10293 | 0 | None | -21 | 3 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 2426360 | 46887 | 6 | None | -8 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 382 | 3 | 3 | 3 | 4.6 | Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 | nan | ||
| CHEMBL1540808 | 46887 | 6 | None | -8 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 382 | 3 | 3 | 3 | 4.6 | Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 | nan | ||
| 9653239 | 107648 | 5 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 291 | 3 | 2 | 4 | 2.7 | O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O | nan | ||
| CHEMBL3190198 | 107648 | 5 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 291 | 3 | 2 | 4 | 2.7 | O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O | nan | ||
| 5730138 | 34794 | 11 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 307 | 4 | 1 | 4 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| CHEMBL1431014 | 34794 | 11 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 307 | 4 | 1 | 4 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| 12005285 | 53064 | 6 | None | 3 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 402 | 8 | 1 | 9 | 4.0 | CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1597454 | 53064 | 6 | None | 3 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 402 | 8 | 1 | 9 | 4.0 | CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 1767917 | 31236 | 10 | None | -3 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 375 | 5 | 3 | 4 | 2.2 | Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br | nan | ||
| CHEMBL1401122 | 31236 | 10 | None | -3 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 375 | 5 | 3 | 4 | 2.2 | Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br | nan | ||
| 14956806 | 106930 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 10 | 1 | 8 | 5.0 | CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314810 | 106930 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 10 | 1 | 8 | 5.0 | CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956768 | 106971 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 499 | 8 | 1 | 7 | 5.2 | CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315077 | 106971 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 499 | 8 | 1 | 7 | 5.2 | CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956745 | 206269 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86906 | 206269 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14951062 | 206391 | 0 | None | -1 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87669 | 206391 | 0 | None | -1 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971694 | 14692 | 0 | None | - | 1 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120605 | 14692 | 0 | None | - | 1 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44355660 | 21557 | 0 | None | 89 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL131676 | 21557 | 0 | None | 89 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 10410730 | 24618 | 0 | None | 6 | 2 | Rabbit | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | ||
| CHEMBL134307 | 24618 | 0 | None | 6 | 2 | Rabbit | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | ||
| 2898434 | 53868 | 12 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 406 | 6 | 0 | 7 | 1.9 | O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1604741 | 53868 | 12 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 406 | 6 | 0 | 7 | 1.9 | O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 3532334 | 42352 | 9 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 303 | 2 | 1 | 4 | 3.2 | O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| CHEMBL1498428 | 42352 | 9 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 303 | 2 | 1 | 4 | 3.2 | O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| 2640418 | 22148 | 7 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 6 | 0 | 6 | 2.5 | O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| CHEMBL1322344 | 22148 | 7 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 6 | 0 | 6 | 2.5 | O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| 5687785 | 108404 | 2 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 3.2 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL3198576 | 108404 | 2 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 3.2 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 5735740 | 41650 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 4.5 | CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| CHEMBL1491932 | 41650 | 10 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 4.5 | CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| 2320855 | 36552 | 6 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1448161 | 36552 | 6 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 | nan | ||
| 5091521 | 25295 | 7 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 402 | 2 | 2 | 9 | 2.9 | CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 | nan | ||
| CHEMBL1348954 | 25295 | 7 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 402 | 2 | 2 | 9 | 2.9 | CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 | nan | ||
| 2121806 | 42065 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 266 | 4 | 1 | 6 | 2.3 | CCSc1nnc(NC(=O)c2ccccn2)s1 | nan | ||
| CHEMBL1495849 | 42065 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 266 | 4 | 1 | 6 | 2.3 | CCSc1nnc(NC(=O)c2ccccn2)s1 | nan | ||
| 2733001 | 29297 | 4 | None | -1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 288 | 5 | 1 | 4 | 3.7 | Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 | nan | ||
| CHEMBL1382939 | 29297 | 4 | None | -1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 288 | 5 | 1 | 4 | 3.7 | Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 | nan | ||
| 25162518 | 39852 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 417 | 8 | 0 | 6 | 2.7 | O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| CHEMBL1477291 | 39852 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 417 | 8 | 0 | 6 | 2.7 | O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| 14956784 | 106557 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314179 | 106557 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956764 | 206077 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85541 | 206077 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44355628 | 24906 | 0 | None | 5 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | ||
| CHEMBL134567 | 24906 | 0 | None | 5 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | ||
| 10095493 | 26048 | 0 | None | 93 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | ||
| CHEMBL135521 | 26048 | 0 | None | 93 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | ||
| 1336623 | 38287 | 20 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 350 | 5 | 0 | 6 | 3.5 | Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 | nan | ||
| CHEMBL1462517 | 38287 | 20 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 350 | 5 | 0 | 6 | 3.5 | Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 | nan | ||
| 2165745 | 34680 | 9 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 425 | 8 | 1 | 8 | 0.7 | O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1430172 | 34680 | 9 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 425 | 8 | 1 | 8 | 0.7 | O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 659805 | 21966 | 6 | None | -2 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 302 | 1 | 2 | 4 | 3.7 | ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 | nan | ||
| CHEMBL1320678 | 21966 | 6 | None | -2 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 302 | 1 | 2 | 4 | 3.7 | ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 | nan | ||
| 135415440 | 199050 | 11 | None | -10 | 5 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 295 | 3 | 2 | 6 | 3.0 | Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 | nan | ||
| CHEMBL586135 | 199050 | 11 | None | -10 | 5 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 295 | 3 | 2 | 6 | 3.0 | Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 | nan | ||
| 579121 | 49132 | 12 | None | -1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 4.7 | COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 | nan | ||
| CHEMBL1561907 | 49132 | 12 | None | -1 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 4.7 | COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 | nan | ||
| 24983202 | 27814 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 444 | 7 | 1 | 6 | 2.9 | CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| CHEMBL1371002 | 27814 | 5 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 444 | 7 | 1 | 6 | 2.9 | CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| 14971686 | 15249 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 507 | 10 | 1 | 8 | 5.2 | CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL121125 | 15249 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 507 | 10 | 1 | 8 | 5.2 | CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10414429 | 115997 | 0 | None | 363 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | ||
| CHEMBL335535 | 115997 | 0 | None | 363 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | ||
| 10322211 | 169472 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1021/jm00078a013 | ||
| CHEMBL442963 | 169472 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1021/jm00078a013 | ||
| 14956741 | 107054 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315615 | 107054 | 0 | None | - | 1 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44292094 | 101444 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 585 | 9 | 1 | 9 | 6.4 | CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL297583 | 101444 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 585 | 9 | 1 | 9 | 6.4 | CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 23205 | 116920 | 40 | None | -7 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 262 | 0 | 1 | 4 | 1.2 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 | nan | ||
| CHEMBL338474 | 116920 | 40 | None | -7 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 262 | 0 | 1 | 4 | 1.2 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 | nan | ||
| 24981067 | 45203 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 480 | 8 | 1 | 7 | 1.8 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| CHEMBL1525764 | 45203 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 480 | 8 | 1 | 7 | 1.8 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| 768473 | 49971 | 6 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 267 | 6 | 0 | 2 | 3.9 | CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| CHEMBL1568922 | 49971 | 6 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 267 | 6 | 0 | 2 | 3.9 | CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| 4799115 | 24530 | 8 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 332 | 3 | 2 | 4 | 4.1 | O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F | nan | ||
| CHEMBL1342423 | 24530 | 8 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 332 | 3 | 2 | 4 | 4.1 | O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F | nan | ||
| 11957260 | 33013 | 6 | None | 5 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 389 | 6 | 2 | 10 | 3.3 | O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| CHEMBL1416184 | 33013 | 6 | None | 5 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 389 | 6 | 2 | 10 | 3.3 | O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 10069786 | 169101 | 0 | None | -19 | 3 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL439968 | 169101 | 0 | None | -19 | 3 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 10393397 | 22799 | 0 | None | 6 | 2 | Rabbit | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL132807 | 22799 | 0 | None | 6 | 2 | Rabbit | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| 568849 | 31721 | 10 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 313 | 7 | 0 | 5 | 3.0 | O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1405657 | 31721 | 10 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 313 | 7 | 0 | 5 | 3.0 | O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 5720743 | 108250 | 10 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 | nan | ||
| CHEMBL3197070 | 108250 | 10 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 | nan | ||
| 761850 | 38794 | 10 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.3 | Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1466556 | 38794 | 10 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.3 | Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] | nan | ||
| 142534050 | 166966 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 545 | 11 | 1 | 7 | 5.2 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4287379 | 166966 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 545 | 11 | 1 | 7 | 5.2 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14971712 | 99603 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 402 | 8 | 3 | 5 | 3.9 | CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL283975 | 99603 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 402 | 8 | 3 | 5 | 3.9 | CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956756 | 206371 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87513 | 206371 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 20081627 | 92170 | 0 | None | -1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24224 | 92170 | 0 | None | -1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459871 | 92530 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 573 | 8 | 1 | 8 | 4.2 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079791 | 92530 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 573 | 8 | 1 | 8 | 4.2 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24319 | 92530 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 573 | 8 | 1 | 8 | 4.2 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| 44459655 | 93225 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 4.3 | CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079788 | 93225 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 4.3 | CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24478 | 93225 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 4.3 | CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459835 | 168039 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 1 | 8 | 4.5 | CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079790 | 168039 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 1 | 8 | 4.5 | CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL432271 | 168039 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 1 | 8 | 4.5 | CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459654 | 168110 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 8 | 1 | 8 | 4.9 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079787 | 168110 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 8 | 1 | 8 | 4.9 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL432847 | 168110 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 8 | 1 | 8 | 4.9 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| 22942227 | 70878 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 569 | 10 | 1 | 9 | 3.5 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951130 | 70878 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 569 | 10 | 1 | 9 | 3.5 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 22942226 | 70879 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 554 | 10 | 2 | 8 | 2.8 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951131 | 70879 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 554 | 10 | 2 | 8 | 2.8 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 142534121 | 166721 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 559 | 11 | 1 | 7 | 5.4 | CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4282931 | 166721 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 559 | 11 | 1 | 7 | 5.4 | CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14971638 | 114875 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.5 | CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL334192 | 114875 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.5 | CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 9845644 | 206433 | 0 | None | 5 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87964 | 206433 | 0 | None | 5 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956779 | 68663 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL19202 | 68663 | 0 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 142533975 | 167048 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4288964 | 167048 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 155517399 | 170181 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 557 | 10 | 1 | 6 | 6.8 | CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| CHEMBL4444760 | 170181 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 557 | 10 | 1 | 6 | 6.8 | CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| 14971699 | 112783 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL330571 | 112783 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44213343 | 70874 | 29 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 9 | 1 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951126 | 70874 | 29 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 9 | 1 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 9935106 | 65282 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL18287 | 65282 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44213346 | 70880 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 525 | 9 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951132 | 70880 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 525 | 9 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971709 | 15347 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 553 | 11 | 2 | 9 | 5.3 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL121416 | 15347 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 553 | 11 | 2 | 9 | 5.3 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 57401930 | 70868 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 500 | 11 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951120 | 70868 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 500 | 11 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 44213342 | 70871 | 15 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 458 | 9 | 2 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951123 | 70871 | 15 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 458 | 9 | 2 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971713 | 167983 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL431887 | 167983 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 57393227 | 70882 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 9 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951134 | 70882 | 0 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 9 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 108185 | 1614 | 78 | None | -3 | 5 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00075a014 | ||
| 586 | 1614 | 78 | None | -3 | 5 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00075a014 | ||
| CHEMBL907 | 1614 | 78 | None | -3 | 5 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00075a014 | ||
| 14971697 | 111541 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.4 | CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327982 | 111541 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.4 | CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10298977 | 206323 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87239 | 206323 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 131654 | 206403 | 12 | None | 1 | 2 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87778 | 206403 | 12 | None | 1 | 2 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971683 | 14862 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120750 | 14862 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971692 | 112953 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.7 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL331078 | 112953 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.7 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10026868 | 23859 | 0 | None | 331 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL133653 | 23859 | 0 | None | 331 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 14956766 | 106979 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315128 | 106979 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2540 | 4401 | 111 | None | -28 | 28 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1014 | 4401 | 111 | None | -28 | 28 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 10409549 | 115978 | 0 | None | 104 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL335514 | 115978 | 0 | None | 104 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10345459 | 116770 | 0 | None | 43 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | ||
| CHEMBL337663 | 116770 | 0 | None | 43 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | ||
| 25163176 | 44092 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 431 | 8 | 0 | 6 | 2.8 | COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 | nan | ||
| CHEMBL1514866 | 44092 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 431 | 8 | 0 | 6 | 2.8 | COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 | nan | ||
| 3116640 | 20407 | 12 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 542 | 6 | 0 | 7 | 2.1 | O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1306605 | 20407 | 12 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 542 | 6 | 0 | 7 | 2.1 | O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 1653162 | 49997 | 11 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 335 | 3 | 3 | 5 | 1.7 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 | nan | ||
| CHEMBL1569107 | 49997 | 11 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 335 | 3 | 3 | 5 | 1.7 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 | nan | ||
| 11957180 | 22744 | 6 | None | 6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 7 | 2 | 10 | 3.7 | O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| CHEMBL1327721 | 22744 | 6 | None | 6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 7 | 2 | 10 | 3.7 | O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| 11957209 | 43034 | 6 | None | 6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1504429 | 43034 | 6 | None | 6 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 9550611 | 49764 | 6 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 6 | 1 | 10 | 3.3 | CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1567159 | 49764 | 6 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 6 | 1 | 10 | 3.3 | CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 780302 | 31883 | 7 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.9 | NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 | nan | ||
| CHEMBL1407100 | 31883 | 7 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.9 | NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 | nan | ||
| 14971681 | 111520 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327862 | 111520 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956771 | 206353 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87392 | 206353 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956750 | 206085 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85596 | 206085 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2412928 | 21717 | 7 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 500 | 7 | 1 | 11 | 1.5 | Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O | nan | ||
| CHEMBL1318653 | 21717 | 7 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 500 | 7 | 1 | 11 | 1.5 | Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O | nan | ||
| 6418891 | 22816 | 13 | None | -1 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 401 | 3 | 0 | 4 | 5.7 | FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 | nan | ||
| CHEMBL1328168 | 22816 | 13 | None | -1 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 401 | 3 | 0 | 4 | 5.7 | FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 | nan | ||
| 2815589 | 41673 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 272 | 5 | 2 | 3 | 2.2 | NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 | nan | ||
| CHEMBL1492089 | 41673 | 5 | None | - | 1 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 272 | 5 | 2 | 3 | 2.2 | NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 | nan | ||
| 16436605 | 38460 | 9 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 | nan | ||
| CHEMBL1464024 | 38460 | 9 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 | nan | ||
| 11159916 | 123851 | 6 | None | - | 1 | Rabbit | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| CHEMBL362550 | 123851 | 6 | None | - | 1 | Rabbit | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| 442142 | 185470 | 16 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 304 | 1 | 0 | 5 | 1.8 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 | nan | ||
| CHEMBL486196 | 185470 | 16 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 304 | 1 | 0 | 5 | 1.8 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 | nan | ||
| 53317942 | 57598 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1667999 | 57598 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| 14971695 | 14871 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.5 | CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120762 | 14871 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.5 | CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44292181 | 101164 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295529 | 101164 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 9982177 | 26499 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL136028 | 26499 | 0 | None | - | 1 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10275744 | 206118 | 0 | None | 2 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85876 | 206118 | 0 | None | 2 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2939837 | 37272 | 7 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 363 | 2 | 3 | 4 | 3.9 | CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| CHEMBL1453857 | 37272 | 7 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 363 | 2 | 3 | 4 | 3.9 | CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| 800048 | 24485 | 28 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 252 | 2 | 0 | 4 | 2.6 | CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 | nan | ||
| CHEMBL1342053 | 24485 | 28 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 252 | 2 | 0 | 4 | 2.6 | CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 | nan | ||
| 972880 | 194364 | 10 | None | -6 | 3 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 268 | 3 | 1 | 5 | 3.7 | Cc1cccnc1Nc1nc(-c2ccccn2)cs1 | nan | ||
| CHEMBL528694 | 194364 | 10 | None | -6 | 3 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 268 | 3 | 1 | 5 | 3.7 | Cc1cccnc1Nc1nc(-c2ccccn2)cs1 | nan | ||
| 9660957 | 72756 | 12 | None | -1 | 5 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 330 | 4 | 0 | 5 | 2.3 | CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 | nan | ||
| CHEMBL1999049 | 72756 | 12 | None | -1 | 5 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 330 | 4 | 0 | 5 | 2.3 | CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 | nan | ||
| 1472225 | 24744 | 11 | None | -5 | 7 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 398 | 6 | 1 | 4 | 3.9 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 | nan | ||
| CHEMBL1344225 | 24744 | 11 | None | -5 | 7 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 398 | 6 | 1 | 4 | 3.9 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 | nan | ||
| 3734285 | 46614 | 17 | None | -2 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.8 | CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 | nan | ||
| CHEMBL1538399 | 46614 | 17 | None | -2 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.8 | CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 | nan | ||
| 5335941 | 107909 | 8 | None | -1 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 279 | 2 | 2 | 2 | 3.4 | CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 | nan | ||
| CHEMBL3193181 | 107909 | 8 | None | -1 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 279 | 2 | 2 | 2 | 3.4 | CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 | nan | ||
| 9590741 | 107848 | 5 | None | -2 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 | nan | ||
| CHEMBL3192432 | 107848 | 5 | None | -2 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 | nan | ||
| 2539399 | 39889 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 392 | 4 | 2 | 5 | 2.4 | Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 | nan | ||
| CHEMBL1477553 | 39889 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 392 | 4 | 2 | 5 | 2.4 | Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 | nan | ||
| 11159916 | 123851 | 6 | None | - | 1 | Rabbit | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| CHEMBL362550 | 123851 | 6 | None | - | 1 | Rabbit | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| 2283939 | 44414 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 404 | 8 | 1 | 6 | 3.7 | Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1518619 | 44414 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 404 | 8 | 1 | 6 | 3.7 | Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] | nan | ||
| 14971685 | 156519 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 582 | 11 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL406791 | 156519 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 582 | 11 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10113613 | 106759 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 7 | 1 | 7 | 4.0 | CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314436 | 106759 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 7 | 1 | 7 | 4.0 | CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956797 | 206419 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87885 | 206419 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10048776 | 115222 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL334622 | 115222 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 1096078 | 49620 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 364 | 4 | 1 | 4 | 4.2 | COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 | nan | ||
| CHEMBL1566084 | 49620 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 364 | 4 | 1 | 4 | 4.2 | COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 | nan | ||
| 2645512 | 32460 | 6 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 455 | 6 | 0 | 6 | 3.3 | O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| CHEMBL1411597 | 32460 | 6 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 455 | 6 | 0 | 6 | 3.3 | O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| 2171031 | 39173 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 356 | 8 | 1 | 6 | 1.7 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1469682 | 39173 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 356 | 8 | 1 | 6 | 1.7 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 889369 | 54486 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 315 | 3 | 3 | 4 | 3.0 | CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| CHEMBL1609718 | 54486 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 315 | 3 | 3 | 4 | 3.0 | CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| 2905495 | 20020 | 14 | None | 1 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 400 | 4 | 1 | 9 | 3.3 | Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C | nan | ||
| CHEMBL1303426 | 20020 | 14 | None | 1 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 400 | 4 | 1 | 9 | 3.3 | Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C | nan | ||
| 3239204 | 54017 | 11 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 319 | 4 | 1 | 7 | 4.0 | COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 | nan | ||
| CHEMBL1605977 | 54017 | 11 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 319 | 4 | 1 | 7 | 4.0 | COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 | nan | ||
| 2848041 | 22082 | 6 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 | nan | ||
| CHEMBL1321754 | 22082 | 6 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 | nan | ||
| 1472220 | 41895 | 11 | None | 3 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 | nan | ||
| CHEMBL1494120 | 41895 | 11 | None | 3 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 | nan | ||
| 135636104 | 44075 | 9 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 217 | 3 | 1 | 5 | 2.7 | O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 | nan | ||
| CHEMBL1514691 | 44075 | 9 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 217 | 3 | 1 | 5 | 2.7 | O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 | nan | ||
| 936147 | 52670 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 306 | 6 | 0 | 4 | 4.3 | CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 | nan | ||
| CHEMBL1593888 | 52670 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 306 | 6 | 0 | 4 | 4.3 | CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 | nan | ||
| 8480343 | 43911 | 6 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 330 | 4 | 2 | 5 | 2.2 | Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 | nan | ||
| CHEMBL1512236 | 43911 | 6 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 330 | 4 | 2 | 5 | 2.2 | Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 | nan | ||
| 2632794 | 22761 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 312 | 5 | 0 | 4 | 3.5 | O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 | nan | ||
| CHEMBL1327815 | 22761 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 312 | 5 | 0 | 4 | 3.5 | O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 | nan | ||
| 14956786 | 106965 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 433 | 9 | 2 | 8 | 2.8 | CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315012 | 106965 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 433 | 9 | 2 | 8 | 2.8 | CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10250898 | 118488 | 0 | None | 37 | 2 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL341407 | 118488 | 0 | None | 37 | 2 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | ||
| 6908540 | 107748 | 19 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 305 | 5 | 1 | 5 | 1.9 | O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 | nan | ||
| CHEMBL3191392 | 107748 | 19 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 305 | 5 | 1 | 5 | 1.9 | O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 | nan | ||
| 2739277 | 29691 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 364 | 4 | 2 | 5 | 4.3 | O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 | nan | ||
| CHEMBL1386393 | 29691 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 364 | 4 | 2 | 5 | 4.3 | O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 | nan | ||
| 135478724 | 35131 | 33 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 240 | 1 | 1 | 2 | 2.9 | O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 | nan | ||
| CHEMBL1434292 | 35131 | 33 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 240 | 1 | 1 | 2 | 2.9 | O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 | nan | ||
| 3118020 | 47486 | 13 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 400 | 6 | 0 | 7 | 1.7 | CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O | nan | ||
| CHEMBL1545561 | 47486 | 13 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 400 | 6 | 0 | 7 | 1.7 | CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O | nan | ||
| 164613537 | 185126 | 0 | None | 21 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4856425 | 185126 | 0 | None | 21 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 10025873 | 115534 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 433 | 4 | 0 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| CHEMBL335323 | 115534 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 433 | 4 | 0 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| 14956765 | 206422 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87890 | 206422 | 0 | None | - | 1 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 773605 | 45178 | 22 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 253 | 2 | 2 | 3 | 3.3 | Fc1ccc(NC(S)=Nc2nccs2)cc1 | nan | ||
| CHEMBL1525546 | 45178 | 22 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 253 | 2 | 2 | 3 | 3.3 | Fc1ccc(NC(S)=Nc2nccs2)cc1 | nan | ||
| 3754656 | 47932 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 362 | 8 | 1 | 6 | 2.6 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 | nan | ||
| CHEMBL1549587 | 47932 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 362 | 8 | 1 | 6 | 2.6 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 | nan | ||
| 933895 | 22718 | 32 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 166 | 2 | 2 | 5 | 1.0 | CC(C)c1nc(C#N)c(NN)o1 | nan | ||
| CHEMBL1327546 | 22718 | 32 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 166 | 2 | 2 | 5 | 1.0 | CC(C)c1nc(C#N)c(NN)o1 | nan | ||
| 42600949 | 54386 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.9 | CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O | nan | ||
| CHEMBL1608922 | 54386 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.9 | CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O | nan | ||
| CHEMBL2131333 | 54386 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.9 | CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O | nan | ||
| 2811327 | 34324 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 288 | 4 | 2 | 2 | 4.0 | CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| CHEMBL1427235 | 34324 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 288 | 4 | 2 | 2 | 4.0 | CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| 2896074 | 45660 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 491 | 3 | 2 | 7 | 5.2 | O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 | nan | ||
| CHEMBL1529705 | 45660 | 8 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 491 | 3 | 2 | 7 | 5.2 | O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 | nan | ||
| 2813088 | 48546 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 290 | 3 | 2 | 5 | 2.9 | Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 | nan | ||
| CHEMBL1556712 | 48546 | 5 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 290 | 3 | 2 | 5 | 2.9 | Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 | nan | ||
| 6887818 | 108137 | 5 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 430 | 4 | 1 | 4 | 4.8 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 | nan | ||
| CHEMBL3195898 | 108137 | 5 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 430 | 4 | 1 | 4 | 4.8 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 | nan | ||
| 2883150 | 50948 | 14 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 413 | 9 | 2 | 7 | 2.7 | CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| CHEMBL1577988 | 50948 | 14 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 413 | 9 | 2 | 7 | 2.7 | CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| 14956788 | 107030 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 447 | 9 | 2 | 8 | 2.9 | CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315469 | 107030 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 447 | 9 | 2 | 8 | 2.9 | CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2321121 | 55454 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 557 | 7 | 1 | 5 | 6.3 | O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1412385 | 55454 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 557 | 7 | 1 | 5 | 6.3 | O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1619819 | 55454 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 557 | 7 | 1 | 5 | 6.3 | O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 2378336 | 36123 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 271 | 6 | 2 | 4 | 2.5 | COc1ccc(C(=O)CNc2ccccc2CO)cc1 | nan | ||
| CHEMBL1444275 | 36123 | 2 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 271 | 6 | 2 | 4 | 2.5 | COc1ccc(C(=O)CNc2ccccc2CO)cc1 | nan | ||
| 3118009 | 44645 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.4 | O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1520643 | 44645 | 10 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.4 | O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 135492609 | 108256 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 521 | 2 | 1 | 7 | 3.6 | CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 | nan | ||
| CHEMBL3197135 | 108256 | 5 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 521 | 2 | 1 | 7 | 3.6 | CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 | nan | ||
| 183134 | 204844 | 17 | None | -134 | 7 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| CHEMBL7550 | 204844 | 17 | None | -134 | 7 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| 11527144 | 179105 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL297425 | 179105 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47177 | 179105 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956749 | 206218 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86613 | 206218 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956803 | 206285 | 0 | None | 10 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86986 | 206285 | 0 | None | 10 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956767 | 206387 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87650 | 206387 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 54500223 | 70872 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 444 | 8 | 2 | 7 | 3.0 | CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951124 | 70872 | 0 | None | - | 1 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 444 | 8 | 2 | 7 | 3.0 | CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 324450 | 40915 | 25 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 219 | 3 | 2 | 3 | 1.4 | O=C(CCl)NNc1cccc(Cl)n1 | nan | ||
| CHEMBL1486528 | 40915 | 25 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 219 | 3 | 2 | 3 | 1.4 | O=C(CCl)NNc1cccc(Cl)n1 | nan | ||
| 3103390 | 44839 | 11 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 410 | 7 | 1 | 7 | 2.1 | O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1522230 | 44839 | 11 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 410 | 7 | 1 | 7 | 2.1 | O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 1231596 | 35850 | 13 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 406 | 4 | 1 | 7 | 4.2 | COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O | nan | ||
| CHEMBL1441794 | 35850 | 13 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 406 | 4 | 1 | 7 | 4.2 | COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O | nan | ||
| 9653430 | 71747 | 3 | None | -3 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 331 | 3 | 2 | 3 | 4.2 | COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 | nan | ||
| CHEMBL1966283 | 71747 | 3 | None | -3 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 331 | 3 | 2 | 3 | 4.2 | COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 | nan | ||
| 161167 | 95491 | 40 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 3.0 | O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 | nan | ||
| CHEMBL257286 | 95491 | 40 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 3.0 | O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 | nan | ||
| 3235730 | 52141 | 12 | None | -2 | 3 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 432 | 8 | 1 | 9 | 3.4 | CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N | nan | ||
| CHEMBL1587831 | 52141 | 12 | None | -2 | 3 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 432 | 8 | 1 | 9 | 3.4 | CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N | nan | ||
| 793994 | 107702 | 7 | None | -1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 304 | 2 | 1 | 4 | 4.9 | Oc1c(/C=N/c2cccc3cccnc23)sc2ccccc12 | nan | ||
| CHEMBL3190827 | 107702 | 7 | None | -1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 304 | 2 | 1 | 4 | 4.9 | Oc1c(/C=N/c2cccc3cccnc23)sc2ccccc12 | nan | ||
| 135444079 | 39143 | 14 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 270 | 1 | 1 | 2 | 3.7 | Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 | nan | ||
| CHEMBL1469448 | 39143 | 14 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 270 | 1 | 1 | 2 | 3.7 | Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 | nan | ||
| 2412176 | 54905 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 259 | 5 | 1 | 3 | 3.1 | COc1ccc(C(=O)CNc2cccc(F)c2)cc1 | nan | ||
| CHEMBL1613520 | 54905 | 7 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 259 | 5 | 1 | 3 | 3.1 | COc1ccc(C(=O)CNc2cccc(F)c2)cc1 | nan | ||
| 10411101 | 165665 | 0 | None | 676 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL424465 | 165665 | 0 | None | 676 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | ||
| 10371403 | 66922 | 20 | None | - | 1 | Rabbit | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| CHEMBL186572 | 66922 | 20 | None | - | 1 | Rabbit | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| 3119388 | 47336 | 12 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 556 | 7 | 0 | 7 | 2.5 | O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1544373 | 47336 | 12 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 556 | 7 | 0 | 7 | 2.5 | O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 4691872 | 47258 | 1 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.8 | COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 | nan | ||
| CHEMBL1543866 | 47258 | 1 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.8 | COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 | nan | ||
| 135557876 | 108255 | 4 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 326 | 4 | 3 | 6 | 2.4 | Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O | nan | ||
| CHEMBL3197126 | 108255 | 4 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 326 | 4 | 3 | 6 | 2.4 | Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O | nan | ||
| 2767330 | 96374 | 26 | None | 1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 272 | 1 | 0 | 3 | 3.7 | Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| CHEMBL261693 | 96374 | 26 | None | 1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 272 | 1 | 0 | 3 | 3.7 | Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| 852940 | 49841 | 12 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 257 | 2 | 1 | 5 | 3.0 | CCc1cc2c(O)nc(-c3ccccn3)nc2s1 | nan | ||
| CHEMBL1567827 | 49841 | 12 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 257 | 2 | 1 | 5 | 3.0 | CCc1cc2c(O)nc(-c3ccccn3)nc2s1 | nan | ||
| 3138587 | 34519 | 3 | None | 1 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 391 | 6 | 5 | 10 | -2.3 | CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 | nan | ||
| CHEMBL1428985 | 34519 | 3 | None | 1 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 391 | 6 | 5 | 10 | -2.3 | CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 | nan | ||
| 1472222 | 28690 | 11 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 414 | 7 | 1 | 5 | 3.6 | COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 | nan | ||
| CHEMBL1377737 | 28690 | 11 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 414 | 7 | 1 | 5 | 3.6 | COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 | nan | ||
| 135443160 | 31717 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 435 | 2 | 1 | 5 | 4.5 | O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 | nan | ||
| CHEMBL1405610 | 31717 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 435 | 2 | 1 | 5 | 4.5 | O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 | nan | ||
| 2920316 | 37674 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 446 | 9 | 1 | 6 | 3.6 | Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1457414 | 37674 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 446 | 9 | 1 | 6 | 3.6 | Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| 4146306 | 25219 | 2 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 347 | 2 | 1 | 4 | 3.3 | O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| CHEMBL1348215 | 25219 | 2 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 347 | 2 | 1 | 4 | 3.3 | O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 20081616 | 92240 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 6 | 2 | 8 | 5.3 | Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24266 | 92240 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 6 | 2 | 8 | 5.3 | Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459656 | 99626 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 3.9 | CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079789 | 99626 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 3.9 | CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL284140 | 99626 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 3.9 | CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| 14956814 | 205800 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 493 | 10 | 1 | 7 | 4.8 | CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83194 | 205800 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 493 | 10 | 1 | 7 | 4.8 | CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971703 | 107088 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL315878 | 107088 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956761 | 105971 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313025 | 105971 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956778 | 206293 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87057 | 206293 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44320509 | 206338 | 0 | None | 1 | 2 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL87327 | 206338 | 0 | None | 1 | 2 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 22942224 | 70885 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 11 | 1 | 9 | 3.9 | CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951137 | 70885 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 11 | 1 | 9 | 3.9 | CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 44292471 | 157552 | 0 | None | - | 1 | Bovine | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 563 | 10 | 3 | 8 | 5.0 | CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| CHEMBL408033 | 157552 | 0 | None | - | 1 | Bovine | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 563 | 10 | 3 | 8 | 5.0 | CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| 54277224 | 70881 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 540 | 9 | 1 | 8 | 3.1 | CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951133 | 70881 | 0 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 540 | 9 | 1 | 8 | 3.1 | CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971718 | 15532 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 388 | 7 | 3 | 5 | 3.5 | CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL121847 | 15532 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 388 | 7 | 3 | 5 | 3.5 | CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956753 | 107070 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315776 | 107070 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971721 | 113183 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 544 | 8 | 2 | 6 | 6.3 | O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| CHEMBL331475 | 113183 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 544 | 8 | 2 | 6 | 6.3 | O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| 4673492 | 4138 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1021/jm9504722 | ||
| 8324 | 4138 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1021/jm9504722 | ||
| CHEMBL159096 | 4138 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1021/jm9504722 | ||
| 14971689 | 12208 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 5.4 | CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL118431 | 12208 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 5.4 | CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44211605 | 170760 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 10 | 1 | 10 | 5.0 | CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44526 | 170760 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 10 | 1 | 10 | 5.0 | CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956809 | 106192 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 656 | 15 | 1 | 9 | 6.5 | CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313837 | 106192 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 656 | 15 | 1 | 9 | 6.5 | CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 132562 | 99683 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm9504722 | ||
| CHEMBL284536 | 99683 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm9504722 | ||
| 57403666 | 70870 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 472 | 9 | 1 | 8 | 3.5 | CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951122 | 70870 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 472 | 9 | 1 | 8 | 3.5 | CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O | 10.1016/j.bmcl.2011.12.116 | ||
| 57396698 | 70875 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 513 | 11 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951127 | 70875 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 513 | 11 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 6918269 | 98470 | 11 | None | -5 | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL275875 | 98470 | 11 | None | -5 | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295959 | 98470 | 11 | None | -5 | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 10027636 | 24594 | 0 | None | 70 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL134286 | 24594 | 0 | None | 70 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 135406019 | 24033 | 15 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 264 | 2 | 1 | 3 | 3.0 | CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 | nan | ||
| CHEMBL1338100 | 24033 | 15 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 264 | 2 | 1 | 3 | 3.0 | CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 | nan | ||
| 3395163 | 29837 | 5 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 441 | 11 | 1 | 7 | 3.5 | CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| CHEMBL1387520 | 29837 | 5 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 441 | 11 | 1 | 7 | 3.5 | CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| 16012865 | 23341 | 9 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 480 | 6 | 1 | 7 | 2.6 | CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| CHEMBL1332454 | 23341 | 9 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 480 | 6 | 1 | 7 | 2.6 | CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| 67903275 | 186523 | 5 | None | 257 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 402 | 7 | 1 | 5 | 4.2 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4877651 | 186523 | 5 | None | 257 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 402 | 7 | 1 | 5 | 4.2 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 142534170 | 166804 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 591 | 9 | 1 | 7 | 5.8 | CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4284403 | 166804 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 591 | 9 | 1 | 7 | 5.8 | CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 44292039 | 182093 | 1 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 547 | 8 | 1 | 8 | 5.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47817 | 182093 | 1 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 547 | 8 | 1 | 8 | 5.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956801 | 206110 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85765 | 206110 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10251520 | 98821 | 0 | None | - | 1 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 419 | 5 | 0 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| CHEMBL278656 | 98821 | 0 | None | - | 1 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 419 | 5 | 0 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| 5731496 | 53183 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 281 | 2 | 1 | 2 | 4.8 | Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 | nan | ||
| CHEMBL1598569 | 53183 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 281 | 2 | 1 | 2 | 4.8 | Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 | nan | ||
| 1613606 | 48023 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 392 | 8 | 1 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1550301 | 48023 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 392 | 8 | 1 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| 44417426 | 141576 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 | 10.1021/jm0603163 | ||
| CHEMBL384936 | 141576 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 | 10.1021/jm0603163 | ||
| 14956751 | 206301 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87073 | 206301 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956802 | 206315 | 0 | None | 1 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87184 | 206315 | 0 | None | 1 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 2347 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 3941 | 2347 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 3961 | 2347 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 590 | 2347 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL191 | 2347 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| DB00678 | 2347 | 95 | None | -134 | 11 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 44355656 | 116084 | 0 | None | - | 1 | Rabbit | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 467 | 6 | 1 | 6 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 | 10.1021/jm00078a013 | ||
| CHEMBL335680 | 116084 | 0 | None | - | 1 | Rabbit | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 467 | 6 | 1 | 6 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 | 10.1021/jm00078a013 | ||
| 44202070 | 39618 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 271 | 1 | 0 | 2 | 3.5 | Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 | nan | ||
| CHEMBL1474191 | 39618 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 271 | 1 | 0 | 2 | 3.5 | Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 | nan | ||
| 1730709 | 24040 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 370 | 8 | 1 | 6 | 3.0 | Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1338165 | 24040 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 370 | 8 | 1 | 6 | 3.0 | Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 2899190 | 52551 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1592181 | 52551 | 9 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] | nan | ||
| 2285607 | 38561 | 10 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 400 | 9 | 1 | 7 | 3.1 | COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1464749 | 38561 | 10 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 400 | 9 | 1 | 7 | 3.1 | COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 | nan | ||
| 44201736 | 27462 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 586 | 9 | 2 | 5 | 5.2 | O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 | nan | ||
| CHEMBL1368499 | 27462 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 586 | 9 | 2 | 5 | 5.2 | O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 | nan | ||
| 16195321 | 51042 | 4 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 413 | 6 | 0 | 5 | 4.9 | CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 | nan | ||
| CHEMBL1578651 | 51042 | 4 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 413 | 6 | 0 | 5 | 4.9 | CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 | nan | ||
| 10344571 | 116614 | 0 | None | 125 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL336773 | 116614 | 0 | None | 125 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 4210369 | 42430 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 4.0 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl | nan | ||
| CHEMBL1499072 | 42430 | 12 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 4.0 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl | nan | ||
| 1726742 | 33395 | 13 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 398 | 9 | 1 | 7 | 2.9 | CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| CHEMBL1419495 | 33395 | 13 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 398 | 9 | 1 | 7 | 2.9 | CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| 9548123 | 47764 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@@H](O)[C@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| CHEMBL1548173 | 47764 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@@H](O)[C@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| 5416363 | 108183 | 3 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 295 | 3 | 1 | 3 | 3.5 | C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 | nan | ||
| CHEMBL3196324 | 108183 | 3 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 295 | 3 | 1 | 3 | 3.5 | C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 | nan | ||
| 44292214 | 175890 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 9 | 2 | 9 | 4.6 | CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL45864 | 175890 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 9 | 2 | 9 | 4.6 | CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 10364891 | 26245 | 0 | None | 33 | 2 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | ||
| CHEMBL135792 | 26245 | 0 | None | 33 | 2 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | ||
| 9550553 | 54521 | 6 | None | 2 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1610025 | 54521 | 6 | None | 2 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 1266032 | 40878 | 6 | None | 3 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 343 | 2 | 0 | 3 | 4.9 | O=C(Sc1cccc2cccnc12)c1ccccc1Br | nan | ||
| CHEMBL1486214 | 40878 | 6 | None | 3 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 343 | 2 | 0 | 3 | 4.9 | O=C(Sc1cccc2cccnc12)c1ccccc1Br | nan | ||
| 9608279 | 107790 | 6 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 366 | 6 | 1 | 8 | 3.1 | COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 | nan | ||
| CHEMBL3191846 | 107790 | 6 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 366 | 6 | 1 | 8 | 3.1 | COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 | nan | ||
| 5341487 | 72351 | 15 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 317 | 3 | 1 | 3 | 3.0 | C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 | nan | ||
| CHEMBL1984876 | 72351 | 15 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 317 | 3 | 1 | 3 | 3.0 | C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 | nan | ||
| 11100 | 125956 | 80 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 192 | 3 | 1 | 4 | 1.8 | O=C(c1ccco1)C(O)c1ccco1 | nan | ||
| CHEMBL364893 | 125956 | 80 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 192 | 3 | 1 | 4 | 1.8 | O=C(c1ccco1)C(O)c1ccco1 | nan | ||
| 135472780 | 28446 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C | nan | ||
| CHEMBL1375373 | 28446 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C | nan | ||
| 2360979 | 38950 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 275 | 5 | 1 | 3 | 3.6 | COc1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1467838 | 38950 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 275 | 5 | 1 | 3 | 3.6 | COc1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| 3106500 | 24789 | 9 | None | -1 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 306 | 3 | 1 | 7 | 1.5 | CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 | nan | ||
| CHEMBL1344603 | 24789 | 9 | None | -1 | 2 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 306 | 3 | 1 | 7 | 1.5 | CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 | nan | ||
| 2431535 | 38923 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 343 | 4 | 0 | 4 | 4.1 | O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl | nan | ||
| CHEMBL1467556 | 38923 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 343 | 4 | 0 | 4 | 4.1 | O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl | nan | ||
| 2324620 | 24899 | 14 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 455 | 4 | 4 | 4 | 4.3 | CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O | nan | ||
| CHEMBL1345564 | 24899 | 14 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 455 | 4 | 4 | 4 | 4.3 | CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O | nan | ||
| 1875884 | 24504 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 436 | 5 | 3 | 6 | 3.0 | COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 | nan | ||
| CHEMBL1342221 | 24504 | 7 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 436 | 5 | 3 | 6 | 3.0 | COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 | nan | ||
| 16012896 | 32999 | 10 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 494 | 7 | 1 | 7 | 3.0 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 | nan | ||
| CHEMBL1416089 | 32999 | 10 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 494 | 7 | 1 | 7 | 3.0 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 | nan | ||
| 2352555 | 52372 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 | nan | ||
| CHEMBL1589900 | 52372 | 6 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 | nan | ||
| 3146836 | 107658 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 399 | 4 | 1 | 6 | 5.6 | CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 | nan | ||
| CHEMBL3190347 | 107658 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 399 | 4 | 1 | 6 | 5.6 | CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 | nan | ||
| 135400342 | 39766 | 7 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 2 | 7 | 2.2 | O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 | nan | ||
| CHEMBL1476264 | 39766 | 7 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 2 | 7 | 2.2 | O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 | nan | ||
| 1612942 | 40836 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 370 | 7 | 1 | 6 | 2.4 | Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 | nan | ||
| CHEMBL1485784 | 40836 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 370 | 7 | 1 | 6 | 2.4 | Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 | nan | ||
| 24818379 | 41098 | 5 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 353 | 6 | 2 | 8 | 1.3 | COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1487991 | 41098 | 5 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 353 | 6 | 2 | 8 | 1.3 | COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] | nan | ||
| 82533 | 41044 | 70 | None | -6 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 | nan | ||
| CHEMBL1487635 | 41044 | 70 | None | -6 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 | nan | ||
| 5286934 | 49301 | 8 | None | -2 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 294 | 9 | 0 | 4 | 2.4 | CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC | nan | ||
| CHEMBL1563483 | 49301 | 8 | None | -2 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 294 | 9 | 0 | 4 | 2.4 | CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC | nan | ||
| 930382 | 34009 | 12 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1424582 | 34009 | 12 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| 2811457 | 34421 | 5 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 4 | 2 | 4 | 3.2 | Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 | nan | ||
| CHEMBL1428121 | 34421 | 5 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 4 | 2 | 4 | 3.2 | Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 | nan | ||
| 14971679 | 111651 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 608 | 10 | 1 | 7 | 7.8 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL328598 | 111651 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 608 | 10 | 1 | 7 | 7.8 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 108185 | 1614 | 78 | None | -3 | 5 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | ||
| 586 | 1614 | 78 | None | -3 | 5 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | ||
| CHEMBL907 | 1614 | 78 | None | -3 | 5 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | ||
| 108185 | 1614 | 78 | None | -3 | 5 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 586 | 1614 | 78 | None | -3 | 5 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| CHEMBL907 | 1614 | 78 | None | -3 | 5 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 14956783 | 205776 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 414 | 8 | 1 | 8 | 2.8 | CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL82920 | 205776 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 414 | 8 | 1 | 8 | 2.8 | CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9612783 | 107924 | 3 | None | 2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 345 | 6 | 1 | 4 | 3.7 | C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 | nan | ||
| CHEMBL3193378 | 107924 | 3 | None | 2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 345 | 6 | 1 | 4 | 3.7 | C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 | nan | ||
| 142534004 | 167358 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4294618 | 167358 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 15229102 | 101192 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295695 | 101192 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 9982458 | 26509 | 0 | None | - | 1 | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 476 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL136034 | 26509 | 0 | None | - | 1 | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 476 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 | 10.1021/jm00078a014 | ||
| 1720698 | 19539 | 12 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 378 | 8 | 1 | 7 | 1.3 | O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1299557 | 19539 | 12 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 378 | 8 | 1 | 7 | 1.3 | O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 2812498 | 43643 | 5 | None | 2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 362 | 5 | 2 | 4 | 4.3 | Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 | nan | ||
| CHEMBL1509694 | 43643 | 5 | None | 2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 362 | 5 | 2 | 4 | 4.3 | Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 | nan | ||
| 888488 | 50698 | 11 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 301 | 5 | 0 | 7 | 1.7 | Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1575784 | 50698 | 11 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 301 | 5 | 0 | 7 | 1.7 | Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] | nan | ||
| 2766929 | 50310 | 26 | None | -20 | 4 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 287 | 1 | 0 | 4 | 3.1 | CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 | nan | ||
| CHEMBL1572001 | 50310 | 26 | None | -20 | 4 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 287 | 1 | 0 | 4 | 3.1 | CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 | nan | ||
| 130606 | 36270 | 54 | None | 1 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.4 | COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 | nan | ||
| CHEMBL1445650 | 36270 | 54 | None | 1 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.4 | COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 | nan | ||
| 44292173 | 172452 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44798 | 172452 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 164616479 | 185316 | 0 | None | 16 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 404 | 7 | 2 | 5 | 3.8 | CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4859498 | 185316 | 0 | None | 16 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 404 | 7 | 2 | 5 | 3.8 | CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 2426323 | 37571 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.6 | Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| CHEMBL1456428 | 37571 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.6 | Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| 1472216 | 50613 | 12 | None | -3 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 384 | 6 | 1 | 4 | 3.6 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 | nan | ||
| CHEMBL1574879 | 50613 | 12 | None | -3 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 384 | 6 | 1 | 4 | 3.6 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 | nan | ||
| 135421501 | 49830 | 16 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 344 | 2 | 1 | 3 | 3.8 | COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| CHEMBL1567702 | 49830 | 16 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 344 | 2 | 1 | 3 | 3.8 | COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| 16193016 | 56129 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 354 | 4 | 0 | 2 | 3.4 | O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1602056 | 56129 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 354 | 4 | 0 | 2 | 3.4 | O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1625597 | 56129 | 6 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 354 | 4 | 0 | 2 | 3.4 | O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 | nan | ||
| 3368605 | 19821 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 504 | 5 | 0 | 6 | 5.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O | nan | ||
| CHEMBL1301939 | 19821 | 9 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 504 | 5 | 0 | 6 | 5.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O | nan | ||
| 2114872 | 20783 | 6 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 2 | 1 | 4 | 3.1 | O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 | nan | ||
| CHEMBL1309573 | 20783 | 6 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 2 | 1 | 4 | 3.1 | O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 | nan | ||
| 2928370 | 45467 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 3.2 | CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 | nan | ||
| CHEMBL1528033 | 45467 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 3.2 | CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 | nan | ||
| 135426090 | 34346 | 12 | None | 3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 318 | 3 | 2 | 6 | 4.0 | Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 | nan | ||
| CHEMBL1427431 | 34346 | 12 | None | 3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 318 | 3 | 2 | 6 | 4.0 | Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 | nan | ||
| 135632169 | 51669 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 419 | 5 | 2 | 7 | 2.4 | O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O | nan | ||
| 136087362 | 51669 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 419 | 5 | 2 | 7 | 2.4 | O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O | nan | ||
| CHEMBL1583998 | 51669 | 8 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 419 | 5 | 2 | 7 | 2.4 | O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O | nan | ||
| 10456041 | 25855 | 0 | None | 186 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135346 | 25855 | 0 | None | 186 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 44459595 | 99457 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 6 | 2 | 7 | 5.1 | CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL2079785 | 99457 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 6 | 2 | 7 | 5.1 | CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL283055 | 99457 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 6 | 2 | 7 | 5.1 | CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459878 | 99707 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 574 | 8 | 1 | 9 | 4.6 | COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL284704 | 99707 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 574 | 8 | 1 | 9 | 4.6 | COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| 53657506 | 70886 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 557 | 10 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951138 | 70886 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 557 | 10 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14956738 | 205798 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83180 | 205798 | 0 | None | - | 1 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9870652 | 70892 | 75 | None | -15 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL1951143 | 70892 | 75 | None | -15 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 11974939 | 82139 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 466 | 5 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL216747 | 82139 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 466 | 5 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 10183373 | 165010 | 0 | None | 3 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL422593 | 165010 | 0 | None | 3 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10183373 | 165010 | 0 | None | 3 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL422593 | 165010 | 0 | None | 3 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 54199501 | 70867 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 486 | 10 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951119 | 70867 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 486 | 10 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 54558598 | 70876 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 10 | 1 | 7 | 3.8 | CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951128 | 70876 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 10 | 1 | 7 | 3.8 | CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 142534183 | 167269 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 503 | 8 | 1 | 7 | 4.0 | CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4293170 | 167269 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 503 | 8 | 1 | 7 | 4.0 | CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956794 | 206078 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85545 | 206078 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 5335625 | 108693 | 10 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 3 | 1 | 3 | 3.2 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL3208035 | 108693 | 10 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 3 | 1 | 3 | 3.2 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 | nan | ||
| 46495021 | 107828 | 5 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 315 | 5 | 1 | 7 | 1.7 | O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 | nan | ||
| CHEMBL3192235 | 107828 | 5 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 315 | 5 | 1 | 7 | 1.7 | O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 | nan | ||
| 14971636 | 114813 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 6.0 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL334083 | 114813 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 6.0 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44292040 | 101135 | 0 | None | - | 1 | Bovine | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 601 | 9 | 1 | 9 | 6.9 | CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295279 | 101135 | 0 | None | - | 1 | Bovine | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 601 | 9 | 1 | 9 | 6.9 | CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 5759185 | 38677 | 5 | None | -5 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 300 | 4 | 0 | 6 | 2.8 | CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 | nan | ||
| CHEMBL1465592 | 38677 | 5 | None | -5 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 300 | 4 | 0 | 6 | 2.8 | CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 | nan | ||
| 5217512 | 42400 | 5 | None | -1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 278 | 3 | 3 | 5 | 2.8 | NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 | nan | ||
| CHEMBL1498886 | 42400 | 5 | None | -1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 278 | 3 | 3 | 5 | 2.8 | NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 | nan | ||
| 10371403 | 66922 | 20 | None | - | 1 | Rabbit | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| CHEMBL186572 | 66922 | 20 | None | - | 1 | Rabbit | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| 14956743 | 164105 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL420970 | 164105 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 56991879 | 70869 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 528 | 13 | 1 | 8 | 4.9 | CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951121 | 70869 | 0 | None | - | 1 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 528 | 13 | 1 | 8 | 4.9 | CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 9618012 | 77918 | 4 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 289 | 3 | 1 | 3 | 3.4 | C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 | nan | ||
| CHEMBL2094484 | 77918 | 4 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 289 | 3 | 1 | 3 | 3.4 | C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 | nan | ||
| 1475345 | 29236 | 11 | None | -1 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 | nan | ||
| CHEMBL1382438 | 29236 | 11 | None | -1 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 | nan | ||
| 18666499 | 175619 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 591 | 9 | 2 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL45805 | 175619 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 591 | 9 | 2 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 11743704 | 115498 | 0 | None | 3 | 2 | Rabbit | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | ||
| CHEMBL335179 | 115498 | 0 | None | 3 | 2 | Rabbit | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | ||
| 44292038 | 182535 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47873 | 182535 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 5218417 | 24814 | 6 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 285 | 3 | 0 | 2 | 3.9 | CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 | nan | ||
| CHEMBL1344824 | 24814 | 6 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 285 | 3 | 0 | 2 | 3.9 | CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 | nan | ||
| 10411653 | 24424 | 0 | None | 208 | 2 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | ||
| CHEMBL134151 | 24424 | 0 | None | 208 | 2 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | ||
| 14956799 | 106899 | 0 | None | - | 1 | Rabbit | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314590 | 106899 | 0 | None | - | 1 | Rabbit | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 6873617 | 72417 | 5 | None | -3 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 386 | 4 | 1 | 4 | 4.7 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 | nan | ||
| CHEMBL1987579 | 72417 | 5 | None | -3 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 386 | 4 | 1 | 4 | 4.7 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 | nan | ||
| 10367704 | 22343 | 0 | None | 25 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL132408 | 22343 | 0 | None | 25 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| 131654 | 206403 | 12 | None | 1 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87778 | 206403 | 12 | None | 1 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956748 | 205973 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL84627 | 205973 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9887844 | 163200 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm9504722 | ||
| CHEMBL418226 | 163200 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm9504722 | ||
| 54393565 | 70887 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951139 | 70887 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 10004112 | 25530 | 0 | None | 93 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL135089 | 25530 | 0 | None | 93 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 10344052 | 116607 | 0 | None | 107 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL336738 | 116607 | 0 | None | 107 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 142534191 | 166783 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 559 | 9 | 1 | 8 | 4.2 | CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4284022 | 166783 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 559 | 9 | 1 | 8 | 4.2 | CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956758 | 106531 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314042 | 106531 | 0 | None | - | 1 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956769 | 107116 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL316052 | 107116 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956762 | 98830 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL278741 | 98830 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 54479908 | 70889 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 525 | 10 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951140 | 70889 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 525 | 10 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14956759 | 206102 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85704 | 206102 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956800 | 206150 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86143 | 206150 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 14956805 | 206344 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87354 | 206344 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9893748 | 182524 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 549 | 9 | 2 | 9 | 4.5 | CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47872 | 182524 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 549 | 9 | 2 | 9 | 4.5 | CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 742856 | 53769 | 21 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 4 | 1 | 2 | 4.3 | O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1603871 | 53769 | 21 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 4 | 1 | 2 | 4.3 | O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 | nan | ||
| 14956789 | 206439 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 489 | 10 | 1 | 9 | 3.7 | CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL88002 | 206439 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 489 | 10 | 1 | 9 | 3.7 | CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2811329 | 28652 | 5 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 3 | 2 | 4 | 3.0 | Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl | nan | ||
| CHEMBL1377329 | 28652 | 5 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 3 | 2 | 4 | 3.0 | Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl | nan | ||
| 4328866 | 19493 | 3 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 247 | 3 | 0 | 4 | 1.2 | CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 | nan | ||
| CHEMBL1299266 | 19493 | 3 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 247 | 3 | 0 | 4 | 1.2 | CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 | nan | ||
| 5770964 | 26455 | 2 | None | 1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 2.6 | COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 | nan | ||
| CHEMBL1359902 | 26455 | 2 | None | 1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 2.6 | COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 | nan | ||
| 2744279 | 26659 | 2 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 351 | 5 | 0 | 10 | 2.5 | CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C | nan | ||
| CHEMBL1361740 | 26659 | 2 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 351 | 5 | 0 | 10 | 2.5 | CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C | nan | ||
| 4068403 | 20722 | 11 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] | nan | ||
| CHEMBL1309127 | 20722 | 11 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] | nan | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 788411 | 27370 | 13 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| CHEMBL1367827 | 27370 | 13 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| 14971674 | 207300 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93289 | 207300 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 15233933 | 101165 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295532 | 101165 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14971693 | 112911 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.5 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL331063 | 112911 | 0 | None | - | 1 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.5 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 18655851 | 101301 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 623 | 9 | 1 | 8 | 6.7 | CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL296519 | 101301 | 0 | None | - | 1 | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 623 | 9 | 1 | 8 | 6.7 | CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 100520 | 32725 | 6 | None | -4 | 4 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 240 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cnc(Sc2ccncn2)s1 | nan | ||
| CHEMBL1413680 | 32725 | 6 | None | -4 | 4 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 240 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cnc(Sc2ccncn2)s1 | nan | ||
| 788410 | 21167 | 15 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(NCC(=O)c2ccccc2)cc1Cl | nan | ||
| CHEMBL1312651 | 21167 | 15 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(NCC(=O)c2ccccc2)cc1Cl | nan | ||
| 44292072 | 101300 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 618 | 9 | 1 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL296518 | 101300 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 618 | 9 | 1 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956773 | 206095 | 0 | None | - | 1 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 504 | 9 | 2 | 6 | 5.0 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85659 | 206095 | 0 | None | - | 1 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 504 | 9 | 2 | 6 | 5.0 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00069a015 | ||
| 44292162 | 172291 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44749 | 172291 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 16446380 | 31622 | 9 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 447 | 7 | 1 | 7 | 3.4 | COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 | nan | ||
| CHEMBL1404578 | 31622 | 9 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 447 | 7 | 1 | 7 | 3.4 | COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 | nan | ||
| 718402 | 33888 | 15 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 | nan | ||
| CHEMBL1423567 | 33888 | 15 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 | nan | ||
| 16437205 | 32003 | 9 | None | -5 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.7 | CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| CHEMBL1407961 | 32003 | 9 | None | -5 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.7 | CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| 6873485 | 107578 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 410 | 7 | 1 | 5 | 4.9 | CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 | nan | ||
| CHEMBL3189289 | 107578 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 410 | 7 | 1 | 5 | 4.9 | CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 | nan | ||
| 9569064 | 72250 | 2 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 363 | 6 | 1 | 4 | 4.0 | C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 | nan | ||
| CHEMBL1981898 | 72250 | 2 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 363 | 6 | 1 | 4 | 4.0 | C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 | nan | ||
| 1481 | 2066 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 3749 | 2066 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 589 | 2066 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 6908 | 2066 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL1513 | 2066 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| DB01029 | 2066 | 116 | None | -2 | 6 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 108185 | 1614 | 78 | None | -3 | 5 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 586 | 1614 | 78 | None | -3 | 5 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| CHEMBL907 | 1614 | 78 | None | -3 | 5 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 57393229 | 70894 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.5 | CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951145 | 70894 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.5 | CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14956740 | 205808 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83248 | 205808 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971677 | 111511 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327837 | 111511 | 0 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956775 | 203981 | 0 | None | -1 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL69508 | 203981 | 0 | None | -1 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956808 | 206431 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 1 | 9 | 4.9 | CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87957 | 206431 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 1 | 9 | 4.9 | CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 330973 | 49689 | 3 | None | -16 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 592 | 4 | 0 | 10 | 3.0 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 | nan | ||
| CHEMBL1566610 | 49689 | 3 | None | -16 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 592 | 4 | 0 | 10 | 3.0 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 | nan | ||
| 2812572 | 25024 | 5 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 274 | 4 | 2 | 2 | 3.7 | CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 | nan | ||
| CHEMBL1346661 | 25024 | 5 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 274 | 4 | 2 | 2 | 3.7 | CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 | nan | ||
| 890649 | 53630 | 14 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 342 | 3 | 0 | 6 | 3.6 | O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 | nan | ||
| CHEMBL1602759 | 53630 | 14 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 342 | 3 | 0 | 6 | 3.6 | O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 | nan | ||
| 44292456 | 101162 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 9 | 1 | 9 | 5.6 | CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295514 | 101162 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 9 | 1 | 9 | 5.6 | CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 16436607 | 24065 | 10 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 | nan | ||
| CHEMBL1338304 | 24065 | 10 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 | nan | ||
| 9619214 | 108077 | 6 | None | -2 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 351 | 5 | 1 | 8 | 2.9 | Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 | nan | ||
| CHEMBL3195226 | 108077 | 6 | None | -2 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 351 | 5 | 1 | 8 | 2.9 | Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 | nan | ||
| 11744592 | 115503 | 0 | None | 33 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | ||
| CHEMBL335228 | 115503 | 0 | None | 33 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | ||
| 6091989 | 49852 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 337 | 5 | 1 | 5 | 4.1 | COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC | nan | ||
| CHEMBL1567899 | 49852 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 337 | 5 | 1 | 5 | 4.1 | COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC | nan | ||
| 44292070 | 171854 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44690 | 171854 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 44292342 | 177259 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL46361 | 177259 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 6883924 | 71691 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 315 | 3 | 1 | 4 | 3.7 | O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl | nan | ||
| CHEMBL1964873 | 71691 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 315 | 3 | 1 | 4 | 3.7 | O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl | nan | ||
| 10366811 | 24826 | 0 | None | 31 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL134491 | 24826 | 0 | None | 31 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | ||
| 3117 | 207841 | 103 | None | -9 | 24 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
| CHEMBL964 | 207841 | 103 | None | -9 | 24 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
| 780062 | 28947 | 7 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 276 | 3 | 2 | 4 | 3.4 | Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 | nan | ||
| CHEMBL1380035 | 28947 | 7 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 276 | 3 | 2 | 4 | 3.4 | Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 | nan | ||
| 10048602 | 26050 | 0 | None | 37 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | ||
| CHEMBL135522 | 26050 | 0 | None | 37 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | ||
| 9556585 | 154912 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 303 | 3 | 1 | 3 | 2.6 | O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 | nan | ||
| CHEMBL400912 | 154912 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 303 | 3 | 1 | 3 | 2.6 | O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 | nan | ||
| 14956800 | 206150 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86143 | 206150 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956810 | 206159 | 0 | None | - | 1 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 566 | 10 | 1 | 8 | 5.9 | CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86232 | 206159 | 0 | None | - | 1 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 566 | 10 | 1 | 8 | 5.9 | CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 135449568 | 41662 | 3 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 286 | 4 | 2 | 7 | 2.5 | COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 | nan | ||
| CHEMBL1492017 | 41662 | 3 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 286 | 4 | 2 | 7 | 2.5 | COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 | nan | ||
| 44292428 | 101094 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 644 | 9 | 1 | 9 | 5.3 | CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL294992 | 101094 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 644 | 9 | 1 | 9 | 5.3 | CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 44291956 | 171274 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 619 | 10 | 1 | 10 | 5.3 | CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44605 | 171274 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 619 | 10 | 1 | 10 | 5.3 | CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956746 | 206194 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86440 | 206194 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 379338 | 16889 | 26 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 288 | 2 | 0 | 4 | 3.4 | COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| CHEMBL125044 | 16889 | 26 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 288 | 2 | 0 | 4 | 3.4 | COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| 14956807 | 106124 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 566 | 12 | 1 | 9 | 4.9 | CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313435 | 106124 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 566 | 12 | 1 | 9 | 4.9 | CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956755 | 106149 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313579 | 106149 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10202093 | 206435 | 0 | None | 2 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87985 | 206435 | 0 | None | 2 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 145987183 | 167232 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 597 | 9 | 1 | 7 | 6.1 | CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4292297 | 167232 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 597 | 9 | 1 | 7 | 6.1 | CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 44291955 | 96626 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL263471 | 96626 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 18942289 | 101330 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 595 | 9 | 1 | 8 | 6.8 | CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL296719 | 101330 | 0 | None | - | 1 | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 595 | 9 | 1 | 8 | 6.8 | CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 10003482 | 165743 | 0 | None | 158 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL424643 | 165743 | 0 | None | 158 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| 14956776 | 105968 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313017 | 105968 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956790 | 171350 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 10 | 2 | 8 | 3.6 | CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL446152 | 171350 | 0 | None | - | 1 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 10 | 2 | 8 | 3.6 | CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 851388 | 55226 | 12 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 229 | 4 | 1 | 2 | 3.1 | O=C(CNc1ccc(F)cc1)c1ccccc1 | nan | ||
| CHEMBL1328306 | 55226 | 12 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 229 | 4 | 1 | 2 | 3.1 | O=C(CNc1ccc(F)cc1)c1ccccc1 | nan | ||
| CHEMBL1617841 | 55226 | 12 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 229 | 4 | 1 | 2 | 3.1 | O=C(CNc1ccc(F)cc1)c1ccccc1 | nan | ||
| 1728272 | 44835 | 12 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 309 | 5 | 3 | 4 | 1.5 | CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 | nan | ||
| CHEMBL1522211 | 44835 | 12 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 309 | 5 | 3 | 4 | 1.5 | CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 | nan | ||
| 135411933 | 41217 | 21 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 300 | 1 | 1 | 2 | 3.5 | O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 | nan | ||
| CHEMBL1488802 | 41217 | 21 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 300 | 1 | 1 | 2 | 3.5 | O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 | nan | ||
| 2796987 | 23373 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 288 | 5 | 2 | 3 | 2.7 | NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1332717 | 23373 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 288 | 5 | 2 | 3 | 2.7 | NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| 379337 | 164207 | 27 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 258 | 1 | 0 | 3 | 3.4 | O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 | nan | ||
| CHEMBL421088 | 164207 | 27 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 258 | 1 | 0 | 3 | 3.4 | O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 | nan | ||
| 788612 | 52326 | 9 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 | nan | ||
| CHEMBL1589540 | 52326 | 9 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 | nan | ||
| 583493 | 42734 | 11 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 255 | 5 | 2 | 3 | 2.7 | O=C(CNc1ccccc1C(=O)O)c1ccccc1 | nan | ||
| CHEMBL1501792 | 42734 | 11 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 255 | 5 | 2 | 3 | 2.7 | O=C(CNc1ccccc1C(=O)O)c1ccccc1 | nan | ||
| 1593681 | 30365 | 8 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 423 | 9 | 2 | 8 | 1.1 | O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1391919 | 30365 | 8 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 423 | 9 | 2 | 8 | 1.1 | O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 10258828 | 14659 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 498 | 9 | 1 | 7 | 5.0 | CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120549 | 14659 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 498 | 9 | 1 | 7 | 5.0 | CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971696 | 113428 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 572 | 9 | 1 | 7 | 6.7 | CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| CHEMBL331886 | 113428 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 572 | 9 | 1 | 7 | 6.7 | CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| 14956782 | 206405 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 457 | 8 | 1 | 7 | 3.8 | CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87780 | 206405 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 457 | 8 | 1 | 7 | 3.8 | CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44341650 | 169887 | 0 | None | -2 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL444060 | 169887 | 0 | None | -2 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 135400371 | 53300 | 20 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 314 | 1 | 1 | 2 | 3.8 | Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 | nan | ||
| CHEMBL1599499 | 53300 | 20 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 314 | 1 | 1 | 2 | 3.8 | Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 | nan | ||
| 135403068 | 23503 | 15 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 358 | 3 | 1 | 3 | 4.2 | CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| CHEMBL1333730 | 23503 | 15 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 358 | 3 | 1 | 3 | 4.2 | CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| 6884203 | 108244 | 10 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 352 | 4 | 1 | 4 | 4.1 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 | nan | ||
| CHEMBL3197021 | 108244 | 10 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 352 | 4 | 1 | 4 | 4.1 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 | nan | ||
| 2989697 | 48748 | 17 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 377 | 5 | 1 | 6 | 2.4 | CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 | nan | ||
| CHEMBL1558462 | 48748 | 17 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 377 | 5 | 1 | 6 | 2.4 | CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 | nan | ||
| 10435200 | 23863 | 0 | None | - | 1 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 478 | 5 | 1 | 7 | 4.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 | 10.1021/jm00078a013 | ||
| CHEMBL133654 | 23863 | 0 | None | - | 1 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 478 | 5 | 1 | 7 | 4.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 | 10.1021/jm00078a013 | ||
| 5953874 | 41102 | 5 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 277 | 2 | 1 | 6 | 2.8 | N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 | nan | ||
| CHEMBL1488024 | 41102 | 5 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 277 | 2 | 1 | 6 | 2.8 | N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 | nan | ||
| 9675542 | 107809 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.8 | Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 | nan | ||
| CHEMBL3191999 | 107809 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.8 | Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 | nan | ||
| 44292215 | 175440 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 605 | 9 | 1 | 10 | 4.8 | CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL45766 | 175440 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 605 | 9 | 1 | 10 | 4.8 | CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956774 | 206238 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86741 | 206238 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 6873171 | 108724 | 6 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 283 | 2 | 1 | 3 | 1.9 | S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 | nan | ||
| CHEMBL3208447 | 108724 | 6 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 283 | 2 | 1 | 3 | 1.9 | S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 | nan | ||
| 14971678 | 14545 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120290 | 14545 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10365283 | 25853 | 0 | None | 416 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135345 | 25853 | 0 | None | 416 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10223724 | 205757 | 0 | None | 1 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL82797 | 205757 | 0 | None | 1 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10479472 | 115225 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 462 | 6 | 1 | 7 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL334660 | 115225 | 0 | None | - | 1 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 462 | 6 | 1 | 7 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| 10344235 | 206160 | 0 | None | -1 | 3 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL86247 | 206160 | 0 | None | -1 | 3 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 10322504 | 26383 | 0 | None | 19 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135929 | 26383 | 0 | None | 19 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 14956747 | 205974 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL84630 | 205974 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971673 | 112360 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.8 | CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL329466 | 112360 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.8 | CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 5339648 | 72952 | 13 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 270 | 4 | 1 | 5 | 1.8 | O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL2005961 | 72952 | 13 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 270 | 4 | 1 | 5 | 1.8 | O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 10322995 | 115263 | 0 | None | 134 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | ||
| CHEMBL334832 | 115263 | 0 | None | 134 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | ||
| 10026268 | 116930 | 0 | None | 173 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | ||
| CHEMBL338505 | 116930 | 0 | None | 173 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | ||
| 854200 | 36032 | 9 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 239 | 4 | 1 | 2 | 3.6 | Cc1ccc(C(=O)CNc2ccccc2C)cc1 | nan | ||
| CHEMBL1443417 | 36032 | 9 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 239 | 4 | 1 | 2 | 3.6 | Cc1ccc(C(=O)CNc2ccccc2C)cc1 | nan | ||
| 973504 | 95222 | 9 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 343 | 4 | 1 | 5 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL256042 | 95222 | 9 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 343 | 4 | 1 | 5 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 | nan | ||
| 44292180 | 180948 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47583 | 180948 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 200953 | 45839 | 8 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 196 | 1 | 0 | 2 | 2.5 | O=C(C#Cc1ccccc1)c1ccco1 | nan | ||
| CHEMBL1531308 | 45839 | 8 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 196 | 1 | 0 | 2 | 2.5 | O=C(C#Cc1ccccc1)c1ccco1 | nan | ||
| 2812483 | 43584 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 245 | 3 | 2 | 4 | 2.4 | Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 | nan | ||
| CHEMBL1509162 | 43584 | 5 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 245 | 3 | 2 | 4 | 2.4 | Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 | nan | ||
| 6873172 | 109082 | 11 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 263 | 2 | 1 | 3 | 1.5 | Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 | nan | ||
| CHEMBL3213140 | 109082 | 11 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 263 | 2 | 1 | 3 | 1.5 | Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 | nan | ||
| 10437543 | 26267 | 0 | None | 7 | 2 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135819 | 26267 | 0 | None | 7 | 2 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| 878879 | 38184 | 10 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccccc1NCC(=O)c1ccc(Br)cc1 | nan | ||
| CHEMBL1461745 | 38184 | 10 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccccc1NCC(=O)c1ccc(Br)cc1 | nan | ||
| 44341785 | 10147 | 0 | None | -3 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL115771 | 10147 | 0 | None | -3 | 3 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 6792924 | 107988 | 10 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 259 | 3 | 1 | 3 | 2.5 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL3194040 | 107988 | 10 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 259 | 3 | 1 | 3 | 2.5 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 | nan | ||
| 1511959 | 21125 | 10 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 359 | 3 | 0 | 8 | 2.0 | CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| CHEMBL1312377 | 21125 | 10 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 359 | 3 | 0 | 8 | 2.0 | CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| 10050755 | 115511 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 478 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL335276 | 115511 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 478 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 | 10.1021/jm00078a014 | ||
| 54508770 | 70873 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 472 | 10 | 2 | 7 | 3.8 | CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951125 | 70873 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 472 | 10 | 2 | 7 | 3.8 | CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971682 | 111487 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 551 | 11 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327718 | 111487 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 551 | 11 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956771 | 206353 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87392 | 206353 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 57393228 | 70890 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 539 | 10 | 1 | 7 | 4.7 | CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951141 | 70890 | 0 | None | - | 1 | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 539 | 10 | 1 | 7 | 4.7 | CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971676 | 163374 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL419321 | 163374 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956776 | 105968 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313017 | 105968 | 0 | None | - | 1 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 824082 | 26481 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 326 | 5 | 0 | 5 | 2.6 | Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1360149 | 26481 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 326 | 5 | 0 | 5 | 2.6 | Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 | nan | ||
| 2564786 | 44700 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 225 | 4 | 1 | 2 | 3.3 | Cc1ccc(C(=O)CNc2ccccc2)cc1 | nan | ||
| CHEMBL1521054 | 44700 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 225 | 4 | 1 | 2 | 3.3 | Cc1ccc(C(=O)CNc2ccccc2)cc1 | nan | ||
| 11754335 | 25303 | 0 | None | 186 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL134901 | 25303 | 0 | None | 186 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | ||
| 1625575 | 54285 | 10 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 297 | 5 | 1 | 5 | 1.5 | CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 | nan | ||
| CHEMBL1608078 | 54285 | 10 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 297 | 5 | 1 | 5 | 1.5 | CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 | nan | ||
| 5680364 | 54904 | 5 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 272 | 2 | 1 | 4 | 0.9 | CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 | nan | ||
| CHEMBL1613515 | 54904 | 5 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 272 | 2 | 1 | 4 | 0.9 | CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 | nan | ||
| 2411934 | 55450 | 2 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 451 | 10 | 2 | 6 | 4.3 | CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C | nan | ||
| CHEMBL1409219 | 55450 | 2 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 451 | 10 | 2 | 6 | 4.3 | CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C | nan | ||
| CHEMBL1619798 | 55450 | 2 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 451 | 10 | 2 | 6 | 4.3 | CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C | nan | ||
| 2170433 | 46191 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 2.3 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1534477 | 46191 | 10 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 2.3 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 9590742 | 107573 | 3 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 | nan | ||
| CHEMBL3189245 | 107573 | 3 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 | nan | ||
| 10434876 | 116618 | 0 | None | 7 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL336808 | 116618 | 0 | None | 7 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 2474590 | 43166 | 4 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 291 | 2 | 1 | 4 | 3.2 | O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 | nan | ||
| CHEMBL1505604 | 43166 | 4 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 291 | 2 | 1 | 4 | 3.2 | O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 | nan | ||
| 9667523 | 108850 | 8 | None | -3 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 328 | 6 | 1 | 6 | 2.3 | C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 | nan | ||
| CHEMBL3210072 | 108850 | 8 | None | -3 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 328 | 6 | 1 | 6 | 2.3 | C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 | nan | ||
| 14956770 | 206257 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 480 | 7 | 1 | 9 | 3.7 | O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86853 | 206257 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 480 | 7 | 1 | 9 | 3.7 | O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956785 | 206392 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 460 | 9 | 2 | 8 | 2.6 | CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87682 | 206392 | 0 | None | - | 1 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 460 | 9 | 2 | 8 | 2.6 | CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1487013 | 51964 | 16 | None | 1 | 3 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 317 | 3 | 1 | 6 | 1.4 | CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1586425 | 51964 | 16 | None | 1 | 3 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 317 | 3 | 1 | 6 | 1.4 | CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 | nan | ||
| 5337284 | 45706 | 6 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 | nan | ||
| CHEMBL1530173 | 45706 | 6 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 | nan | ||
| 991372 | 53850 | 33 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 382 | 1 | 2 | 5 | 4.5 | CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O | nan | ||
| CHEMBL1604546 | 53850 | 33 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 382 | 1 | 2 | 5 | 4.5 | CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O | nan | ||
| 135472791 | 22335 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 | nan | ||
| CHEMBL1324011 | 22335 | 7 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 | nan | ||
| 788618 | 20004 | 11 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 | nan | ||
| CHEMBL1303334 | 20004 | 11 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 | nan | ||
| 788408 | 43545 | 13 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 | nan | ||
| CHEMBL1508797 | 43545 | 13 | None | - | 1 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 | nan | ||
| 6918269 | 98470 | 11 | None | 5 | 2 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL275875 | 98470 | 11 | None | 5 | 2 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL295959 | 98470 | 11 | None | 5 | 2 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 11527144 | 179105 | 0 | None | - | 1 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL297425 | 179105 | 0 | None | - | 1 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL47177 | 179105 | 0 | None | - | 1 | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 133031 | 100859 | 21 | None | -1 | 3 | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL293511 | 100859 | 21 | None | -1 | 3 | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 9887844 | 163200 | 4 | None | - | 1 | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL418226 | 163200 | 4 | None | - | 1 | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| 9911332 | 44701 | 1 | None | - | 0 | Rabbit | 10.2 | pKd | = | 10.2 | Functional | ChEMBL | 444 | 7 | 2 | 6 | 4.7 | CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9604383 | ||
| CHEMBL152106 | 44701 | 1 | None | - | 0 | Rabbit | 10.2 | pKd | = | 10.2 | Functional | ChEMBL | 444 | 7 | 2 | 6 | 4.7 | CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9604383 | ||
| 132387 | 162334 | 23 | None | - | 0 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL416477 | 162334 | 23 | None | - | 0 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| 108185 | 1614 | 78 | None | -3 | 5 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 586 | 1614 | 78 | None | -3 | 5 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL907 | 1614 | 78 | None | -3 | 5 | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 9802561 | 161251 | 26 | None | - | 0 | Rabbit | 10.0 | pKd | = | 10.0 | Functional | ChEMBL | 426 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL41194 | 161251 | 26 | None | - | 0 | Rabbit | 10.0 | pKd | = | 10.0 | Functional | ChEMBL | 426 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| 19890807 | 111534 | 0 | None | - | 0 | Rabbit | 10.0 | pKd | = | 10 | Functional | ChEMBL | 466 | 8 | 1 | 7 | 5.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 | 10.1021/jm00070a012 | ||
| CHEMBL327932 | 111534 | 0 | None | - | 0 | Rabbit | 10.0 | pKd | = | 10 | Functional | ChEMBL | 466 | 8 | 1 | 7 | 5.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 | 10.1021/jm00070a012 | ||
| 15657904 | 187482 | 4 | None | - | 0 | Rabbit | 9.9 | pKd | = | 9.9 | Functional | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL49410 | 187482 | 4 | None | - | 0 | Rabbit | 9.9 | pKd | = | 9.9 | Functional | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| 19017678 | 176153 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 474 | 11 | 2 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL45927 | 176153 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 474 | 11 | 2 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| 9935096 | 207771 | 1 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL9599 | 207771 | 1 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44373246 | 168267 | 0 | None | - | 1 | Rabbit | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL433895 | 168267 | 0 | None | - | 1 | Rabbit | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL2373017 | 210354 | 0 | None | - | 0 | Rat | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCSSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O | 10.1021/jm00169a019 | ||||
| 9912059 | 185356 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Functional | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL48602 | 185356 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Functional | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 131654 | 206403 | 12 | None | 1 | 2 | Rabbit | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL87778 | 206403 | 12 | None | 1 | 2 | Rabbit | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 9801006 | 119729 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL347610 | 119729 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1016/j.bmc.2010.10.043 | ||
| 178553 | 120244 | 14 | None | - | 0 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 387 | 6 | 1 | 6 | 4.1 | COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL352257 | 120244 | 14 | None | - | 0 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 387 | 6 | 1 | 6 | 4.1 | COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1016/j.bmc.2010.10.043 | ||
| 70682146 | 76331 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058860 | 76331 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 46910493 | 76335 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058864 | 76335 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 9931685 | 206084 | 0 | None | 1 | 2 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL85595 | 206084 | 0 | None | 1 | 2 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | ||
| 131857 | 204259 | 20 | None | - | 0 | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 383 | 5 | 1 | 4 | 5.0 | Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL71162 | 204259 | 20 | None | - | 0 | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 383 | 5 | 1 | 4 | 5.0 | Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438885 | 90954 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8 | Functional | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL239378 | 90954 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8 | Functional | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 2541 | 786 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| 587 | 786 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| 6907 | 786 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL1016 | 786 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| DB00796 | 786 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| DB13919 | 786 | 120 | None | - | 10 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| 10094851 | 21297 | 0 | None | - | 1 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL131365 | 21297 | 0 | None | - | 1 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 1610 | 2347 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 3941 | 2347 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 3961 | 2347 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 590 | 2347 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL191 | 2347 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| DB00678 | 2347 | 95 | None | -9 | 11 | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 24827770 | 95880 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| CHEMBL259114 | 95880 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| 44438869 | 146335 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL392118 | 146335 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | ||
| 44438900 | 147848 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL393305 | 147848 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 44570265 | 178409 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 519 | 12 | 2 | 5 | 5.9 | CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL465929 | 178409 | 0 | None | - | 0 | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 519 | 12 | 2 | 5 | 5.9 | CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 19351553 | 118698 | 0 | None | - | 0 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 389 | 10 | 4 | 6 | 3.1 | CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL341716 | 118698 | 0 | None | - | 0 | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 389 | 10 | 4 | 6 | 3.1 | CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL264230 | 210609 | 0 | None | - | 0 | Rabbit | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | None | None | None | CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | ||||
| CHEMBL384349 | 212323 | 0 | None | - | 0 | Rabbit | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | ||||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 44438865 | 93375 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL245644 | 93375 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 44570305 | 190318 | 0 | None | - | 0 | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 545 | 10 | 2 | 5 | 6.4 | CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL517626 | 190318 | 0 | None | - | 0 | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 545 | 10 | 2 | 5 | 6.4 | CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 44348352 | 16528 | 0 | None | 1 | 2 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL123713 | 16528 | 0 | None | 1 | 2 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 44570215 | 183551 | 0 | None | - | 0 | Rat | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 477 | 9 | 2 | 5 | 4.7 | CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL480018 | 183551 | 0 | None | - | 0 | Rat | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 477 | 9 | 2 | 5 | 4.7 | CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 9906367 | 52149 | 0 | None | - | 0 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 349 | 4 | 1 | 5 | 3.1 | C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL158794 | 52149 | 0 | None | - | 0 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 349 | 4 | 1 | 5 | 3.1 | C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438902 | 169396 | 0 | None | - | 1 | Rabbit | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL442251 | 169396 | 0 | None | - | 1 | Rabbit | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 46910495 | 76332 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058861 | 76332 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 24828707 | 95937 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| CHEMBL259353 | 95937 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| 44438870 | 92005 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241685 | 92005 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 10250336 | 18886 | 0 | None | - | 1 | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL128318 | 18886 | 0 | None | - | 1 | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 53323218 | 60252 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 417 | 7 | 2 | 5 | 4.5 | CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1668010 | 60252 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 417 | 7 | 2 | 5 | 4.5 | CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1741079 | 60252 | 0 | None | - | 0 | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 417 | 7 | 2 | 5 | 4.5 | CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 25110812 | 179039 | 0 | None | - | 0 | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 455 | 9 | 2 | 4 | 6.1 | CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL471334 | 179039 | 0 | None | - | 0 | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 455 | 9 | 2 | 4 | 6.1 | CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 44570214 | 183550 | 0 | None | - | 0 | Rat | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 463 | 8 | 2 | 5 | 4.4 | CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL480017 | 183550 | 0 | None | - | 0 | Rat | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 463 | 8 | 2 | 5 | 4.4 | CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 9932483 | 207843 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL9642 | 207843 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| 9954408 | 207967 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL9714 | 207967 | 0 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 25112615 | 185891 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 503 | 9 | 2 | 4 | 7.0 | CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL486847 | 185891 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 503 | 9 | 2 | 4 | 7.0 | CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 44570306 | 178297 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 464 | 8 | 2 | 5 | 5.0 | CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL465097 | 178297 | 0 | None | - | 0 | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 464 | 8 | 2 | 5 | 5.0 | CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 15224471 | 154833 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL400424 | 154833 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 2541 | 786 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| 587 | 786 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| 6907 | 786 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL1016 | 786 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| DB00796 | 786 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| DB13919 | 786 | 120 | None | - | 10 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| 4110026 | 204935 | 1 | None | - | 2 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL7632 | 204935 | 1 | None | - | 2 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 57380647 | 70354 | 0 | None | - | 2 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL1945010 | 70354 | 0 | None | - | 2 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| 9823146 | 19361 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL12909 | 19361 | 0 | None | - | 1 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | ||
| 1610 | 2347 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3941 | 2347 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3961 | 2347 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 590 | 2347 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL191 | 2347 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| DB00678 | 2347 | 95 | None | -9 | 11 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 9801627 | 52062 | 17 | None | - | 0 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 409 | 7 | 1 | 6 | 4.7 | CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL158725 | 52062 | 17 | None | - | 0 | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 409 | 7 | 1 | 6 | 4.7 | CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 17748251 | 93347 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL245444 | 93347 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 44570266 | 190815 | 0 | None | - | 0 | Rat | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 519 | 9 | 2 | 5 | 5.9 | CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL518388 | 190815 | 0 | None | - | 0 | Rat | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 519 | 9 | 2 | 5 | 5.9 | CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 9938452 | 117915 | 0 | None | - | 0 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 591 | 13 | 2 | 6 | 8.1 | CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL340315 | 117915 | 0 | None | - | 0 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 591 | 13 | 2 | 6 | 8.1 | CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 17748251 | 93347 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL245444 | 93347 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438868 | 92004 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241684 | 92004 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 44438901 | 91987 | 0 | None | - | 1 | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241529 | 91987 | 0 | None | - | 1 | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 25112616 | 185892 | 0 | None | - | 0 | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL486848 | 185892 | 0 | None | - | 0 | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL415157 | 213174 | 0 | None | - | 0 | Rabbit | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | ||||
| 1610 | 2347 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 3941 | 2347 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 3961 | 2347 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 590 | 2347 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL191 | 2347 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| DB00678 | 2347 | 95 | None | -9 | 11 | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 25112614 | 191623 | 0 | None | - | 0 | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL519564 | 191623 | 0 | None | - | 0 | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 70686410 | 76330 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058859 | 76330 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 57380414 | 70530 | 0 | None | - | 2 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL1947131 | 70530 | 0 | None | - | 2 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| 44339988 | 161007 | 0 | None | - | 0 | Rabbit | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | ||
| CHEMBL411624 | 161007 | 0 | None | - | 0 | Rabbit | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | ||
| 132562 | 99683 | 6 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL284536 | 99683 | 6 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | ||
| 53325868 | 57601 | 0 | None | - | 0 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 515 | 12 | 2 | 6 | 5.8 | CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1668002 | 57601 | 0 | None | - | 0 | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 515 | 12 | 2 | 6 | 5.8 | CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438880 | 91986 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241523 | 91986 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 132706 | 1676 | 24 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| 6896 | 1676 | 24 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL315021 | 1676 | 24 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| DB01342 | 1676 | 24 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| 57380412 | 70528 | 0 | None | - | 2 | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL1947129 | 70528 | 0 | None | - | 2 | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| 44570264 | 190707 | 0 | None | - | 0 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 505 | 10 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL518230 | 190707 | 0 | None | - | 0 | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 505 | 10 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 25112617 | 186757 | 0 | None | - | 0 | Rat | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL488883 | 186757 | 0 | None | - | 0 | Rat | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL268804 | 210764 | 0 | None | - | 0 | Rabbit | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | ||||
| 44438872 | 169106 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL440051 | 169106 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 15069306 | 179062 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 469 | 10 | 2 | 4 | 6.5 | CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL471505 | 179062 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 469 | 10 | 2 | 4 | 6.5 | CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 44570217 | 183234 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 505 | 11 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL479626 | 183234 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 505 | 11 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 44570216 | 190057 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 5.1 | CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL517230 | 190057 | 0 | None | - | 0 | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 5.1 | CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 6918269 | 98470 | 11 | None | - | 2 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL275875 | 98470 | 11 | None | - | 2 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL295959 | 98470 | 11 | None | - | 2 | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rat | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 1610 | 2347 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 3941 | 2347 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 3961 | 2347 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 590 | 2347 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| CHEMBL191 | 2347 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| DB00678 | 2347 | 95 | None | -19 | 11 | Rat | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00103a014 | ||
| 6917 | 132 | 0 | None | - | 1 | Human | 7.8 | pA2 | = | 7.8 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 73755250 | 132 | 0 | None | - | 1 | Human | 7.8 | pA2 | = | 7.8 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 11943 | 3875 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 145925549 | 3875 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| CHEMBL4438122 | 3875 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 123814 | 421 | 30 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 12006574 | ||||
| 5368 | 421 | 30 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 12006574 | ||||
| CHEMBL261120 | 421 | 30 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | None | None | None | None | 12006574 | ||||
| 6894 | 418 | 0 | None | -56 | 3 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 21464395 | ||||
| 91691124 | 418 | 0 | None | -56 | 3 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 21464395 | ||||
| 6905 | 3485 | 0 | None | - | 1 | Rat | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | None | None | None | None | 7499361 | ||||
| 135409642 | 217735 | 0 | None | 1 | 2 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 | None | ||
| 2540 | 4401 | 111 | None | 1 | 28 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | ||
| CHEMBL1014 | 4401 | 111 | None | 1 | 28 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | ||
| 3839 | 3757 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| 60919 | 3757 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| 6898 | 3757 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| CHEMBL432162 | 3757 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| DB01349 | 3757 | 84 | None | 794 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| 130881 | 2921 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 1985 | 2921 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 591 | 2921 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| CHEMBL1200692 | 2921 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| DB00275 | 2921 | 108 | None | -2 | 3 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 130881 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 1985 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 591 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| CHEMBL1200692 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| DB00275 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 135409642 | 217735 | 0 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOC1=NC2=CC=CC(C(=O)OCC3=C(C)OC(=O)O3)=C2N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NOC(=O)N1 | None | ||
| 16133225 | 419 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 172198 | 419 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 2504 | 419 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 45266664 | 419 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 5272 | 419 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| CHEMBL408403 | 419 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| DB11842 | 419 | 52 | None | -5 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | None | None | None | None | None | ||||
| 9870652 | 70892 | 75 | None | -15 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | None | ||
| CHEMBL1951143 | 70892 | 75 | None | -15 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | None | ||
| 1610 | 2347 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 3941 | 2347 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 3961 | 2347 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 590 | 2347 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| CHEMBL191 | 2347 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| DB00678 | 2347 | 95 | None | -9 | 11 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 3936 | 2210 | 35 | None | -1 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 7829475 | ||
| 6603900 | 2210 | 35 | None | -1 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 7829475 | ||
| CHEMBL288174 | 2210 | 35 | None | -1 | 6 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 7829475 | ||
| 6895 | 2211 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 580 | 9 | 1 | 6 | 6.6 | CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C | 9383393 | ||
| 73755245 | 2211 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 580 | 9 | 1 | 6 | 6.6 | CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C | 9383393 | ||
| 1610 | 2347 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 3941 | 2347 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 3961 | 2347 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 590 | 2347 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| CHEMBL191 | 2347 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| DB00678 | 2347 | 95 | None | -9 | 11 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 139031070 | 2839 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 714 | 11 | 0 | 10 | 2.6 | CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] | 23376252 | ||
| 6911 | 2839 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 714 | 11 | 0 | 10 | 2.6 | CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] | 23376252 | ||
| 73755247 | 2839 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 714 | 11 | 0 | 10 | 2.6 | CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] | 23376252 | ||
| 130881 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| 1985 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| 591 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| CHEMBL1200692 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| DB00275 | 2921 | 108 | None | 2 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| 135415867 | 560 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24739538 | ||
| 135415867 | 560 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24742498 | ||
| 6901 | 560 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24739538 | ||
| 6901 | 560 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24742498 | ||
| CHEMBL57242 | 560 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24739538 | ||
| CHEMBL57242 | 560 | 97 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24742498 | ||
| 6909 | 2408 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 73755246 | 2408 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 10416728 | 2409 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 6910 | 2409 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| CHEMBL344662 | 2409 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 132706 | 1676 | 24 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| 6896 | 1676 | 24 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| CHEMBL315021 | 1676 | 24 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| DB01342 | 1676 | 24 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| 2583 | 3776 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| 592 | 3776 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| 65999 | 3776 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| CHEMBL1017 | 3776 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| DB00966 | 3776 | 118 | None | -1 | 16 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| 4673492 | 4138 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 8576904 | ||
| 8324 | 4138 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 8576904 | ||
| CHEMBL159096 | 4138 | 9 | None | 5248 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 8576904 | ||
| 108185 | 1614 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10193788 | ||
| 108185 | 1614 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 8372104 | ||
| 586 | 1614 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10193788 | ||
| 586 | 1614 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 8372104 | ||
| CHEMBL907 | 1614 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10193788 | ||
| CHEMBL907 | 1614 | 78 | None | 3 | 5 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 8372104 | ||
| 44299731 | 420 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 585 | 420 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| CHEMBL56448 | 420 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 6917 | 132 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 73755250 | 132 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 1037 | 1578 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 3940 | 1578 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 5281037 | 1578 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 588 | 1578 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| CHEMBL813 | 1578 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| DB00876 | 1578 | 69 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 2806 | 3969 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 3937 | 3969 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 593 | 3969 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 60846 | 3969 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| CHEMBL1069 | 3969 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| DB00177 | 3969 | 110 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 1481 | 2066 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 3749 | 2066 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 589 | 2066 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 6908 | 2066 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| CHEMBL1513 | 2066 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| DB01029 | 2066 | 116 | None | -2 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 136218976 | 150 | 0 | None | - | 1 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | ||
| 6913 | 150 | 0 | None | - | 1 | Rat | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | ||
| 2806 | 3969 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 3937 | 3969 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 593 | 3969 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 60846 | 3969 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| CHEMBL1069 | 3969 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| DB00177 | 3969 | 110 | None | 1 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 3839 | 3757 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| 60919 | 3757 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| 6898 | 3757 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| CHEMBL432162 | 3757 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| DB01349 | 3757 | 84 | None | 794 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| 16133225 | 419 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 172198 | 419 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 2504 | 419 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 45266664 | 419 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 5272 | 419 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| CHEMBL408403 | 419 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| DB11842 | 419 | 52 | None | -5 | 4 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 10193788 | ||||
| 6894 | 418 | 0 | None | -2 | 3 | Rat | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | None | None | None | None | 17138938 | ||||
| 91691124 | 418 | 0 | None | -2 | 3 | Rat | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | None | None | None | None | 17138938 | ||||
| 2541 | 786 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| 587 | 786 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| 6907 | 786 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| CHEMBL1016 | 786 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| DB00796 | 786 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| DB13919 | 786 | 120 | None | 15 | 10 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 2541 | 786 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 587 | 786 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 6907 | 786 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1016 | 786 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB00796 | 786 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB13919 | 786 | 120 | None | -1 | 6 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 158781 | 44166 | 98 | None | - | 0 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1516 | 44166 | 98 | None | - | 0 | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 2541 | 786 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 587 | 786 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 6907 | 786 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1016 | 786 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB00796 | 786 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| DB13919 | 786 | 120 | None | -1 | 6 | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 158781 | 44166 | 98 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1516 | 44166 | 98 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 130881 | 2921 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1985 | 2921 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 591 | 2921 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200692 | 2921 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00275 | 2921 | 108 | None | - | 0 | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 130881 | 2921 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1985 | 2921 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 591 | 2921 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200692 | 2921 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00275 | 2921 | 108 | None | - | 0 | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1037 | 1578 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 1578 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 1578 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 588 | 1578 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| DB00876 | 1578 | 69 | None | - | 1 | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 242 | 470 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| 34 | 470 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| 60795 | 470 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1112 | 470 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| DB01238 | 470 | 124 | None | - | 51 | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| 216239 | 23795 | 118 | None | - | 7 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200485 | 23795 | 118 | None | - | 7 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1336 | 23795 | 118 | None | - | 7 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| 25181577 | 78219 | 56 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2105695 | 78219 | 56 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 54682461 | 84686 | 62 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 602 | 11 | 2 | 6 | 7.3 | CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL222559 | 84686 | 62 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 602 | 11 | 2 | 6 | 7.3 | CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 | 10.1038/s41467-023-40064-9 | |||
| 441290 | 14477 | 36 | None | - | 0 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.4 | C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201244 | 14477 | 36 | None | - | 0 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.4 | C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 | 10.1038/s41467-023-40064-9 | |||
| 65948 | 18556 | 109 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 582 | 9 | 2 | 9 | 4.7 | CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1275868 | 18556 | 109 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 582 | 9 | 2 | 9 | 4.7 | CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 | 10.1038/s41467-023-40064-9 | |||
| 5077 | 3578 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 7552 | 3578 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 9913767 | 3578 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL238804 | 3578 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| DB11362 | 3578 | 79 | None | - | 4 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 64139 | 84785 | 96 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 315 | 0 | 1 | 2 | 4.1 | O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL223228 | 84785 | 96 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 315 | 0 | 1 | 2 | 4.1 | O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 | 10.1038/s41467-023-40064-9 | |||
| 2540 | 4401 | 111 | None | - | 4 | Human | 7.9 | pAC50 | = | 7.9 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1014 | 4401 | 111 | None | - | 4 | Human | 7.9 | pAC50 | = | 7.9 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 180 | 401 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| 200 | 401 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| 2160 | 401 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL629 | 401 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| DB00321 | 401 | 56 | None | - | 40 | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| 3149 | 12614 | 15 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 334 | 15 | 0 | 1 | 6.1 | CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1187011 | 12614 | 15 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 334 | 15 | 0 | 1 | 6.1 | CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 1549120 | 196486 | 85 | None | - | 0 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.9 | CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL56337 | 196486 | 85 | None | - | 0 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.9 | CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5281034 | 14426 | 29 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 332 | 0 | 2 | 3 | 4.4 | C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200585 | 14426 | 29 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 332 | 0 | 2 | 3 | 4.4 | C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O | 10.1038/s41467-023-40064-9 | |||
| 3599 | 16879 | 88 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 407 | 20 | 0 | 4 | 5.7 | CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL125 | 16879 | 88 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 407 | 20 | 0 | 4 | 5.7 | CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C | 10.1038/s41467-023-40064-9 | |||
| 5591 | 157531 | 90 | None | - | 2 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 4.4 | Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL408 | 157531 | 90 | None | - | 2 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 4.4 | Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 | 10.1038/s41467-023-40064-9 | |||
| 3152 | 188411 | 103 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL502 | 188411 | 103 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| 2333 | 142335 | 97 | None | - | 2 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 422 | 3 | 1 | 3 | 5.5 | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL388590 | 142335 | 97 | None | - | 2 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 422 | 3 | 1 | 3 | 5.5 | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 | 10.1038/s41467-023-40064-9 | |||
| 5803 | 162227 | 84 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 622 | 4 | 2 | 3 | 4.6 | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL41632 | 162227 | 84 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 622 | 4 | 2 | 3 | 4.6 | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 | 10.1038/s41467-023-40064-9 | |||
| 104850 | 3330 | 96 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 4150 | 3330 | 96 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 743 | 3330 | 96 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL111 | 3330 | 96 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| DB06155 | 3330 | 96 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 2540 | 4401 | 111 | None | - | 4 | Human | 7.8 | pAC50 | = | 7.8 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1014 | 4401 | 111 | None | - | 4 | Human | 7.8 | pAC50 | = | 7.8 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 5852 | 2617 | 55 | None | - | 4 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 419 | 11 | 1 | 5 | 4.9 | OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 9931891 | 2617 | 55 | None | - | 4 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 419 | 11 | 1 | 5 | 4.9 | OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL239226 | 2617 | 55 | None | - | 4 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 419 | 11 | 1 | 5 | 4.9 | OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 5318 | 15576 | 49 | None | - | 13 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 396 | 6 | 0 | 3 | 6.5 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200348 | 15576 | 49 | None | - | 13 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 396 | 6 | 0 | 3 | 6.5 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1221 | 15576 | 49 | None | - | 13 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 396 | 6 | 0 | 3 | 6.5 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| 1385580 | 29276 | 76 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 4615 | 29276 | 76 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL13828 | 29276 | 76 | None | - | 5 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 1056 | 3371 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| 2405 | 3371 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| 77999 | 3371 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL121 | 3371 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| DB00412 | 3371 | 116 | None | - | 1 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| 40973 | 46035 | 70 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 310 | 1 | 1 | 1 | 4.9 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1533 | 46035 | 70 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 310 | 1 | 1 | 1 | 4.9 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| 135409453 | 3773 | 41 | None | - | 2 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| 226 | 3773 | 41 | None | - | 2 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| CHEMBL76370 | 3773 | 41 | None | - | 2 | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| 3516 | 208123 | 100 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 198 | 5 | 2 | 4 | 0.4 | COc1ccccc1OCC(O)CO | 10.1038/s41467-023-40064-9 | |||
| CHEMBL980 | 208123 | 100 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 198 | 5 | 2 | 4 | 0.4 | COc1ccccc1OCC(O)CO | 10.1038/s41467-023-40064-9 | |||
| 135398735 | 136968 | 32 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| 136262914 | 136968 | 32 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL374478 | 136968 | 32 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| 72093 | 35061 | 9 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1433361 | 35061 | 9 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2103773 | 35061 | 9 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | |||
| 4495 | 196535 | 92 | None | - | 29 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL56367 | 196535 | 92 | None | - | 29 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 2303 | 3187 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 4946 | 3187 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 564 | 3187 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 63 | 3187 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 91536 | 3187 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL27 | 3187 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL452861 | 3187 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00571 | 3187 | 68 | None | - | 26 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 25025298 | 78151 | 39 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 546 | 8 | 3 | 8 | 4.5 | Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2103855 | 78151 | 39 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 546 | 8 | 3 | 8 | 4.5 | Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 | 10.1038/s41467-023-40064-9 | |||
| 5280453 | 205971 | 74 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 416 | 6 | 3 | 3 | 5.7 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL846 | 205971 | 74 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 416 | 6 | 3 | 3 | 5.7 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| 54454 | 5258 | 88 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 418 | 6 | 1 | 5 | 4.6 | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1064 | 5258 | 88 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 418 | 6 | 1 | 5 | 4.6 | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| 6540478 | 14447 | 41 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 369 | 2 | 1 | 4 | 4.7 | C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200934 | 14447 | 41 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 369 | 2 | 1 | 4 | 4.7 | C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| 51755 | 57406 | 54 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 454 | 8 | 0 | 4 | 7.3 | Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1651990 | 57406 | 54 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 454 | 8 | 0 | 4 | 7.3 | Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 | 10.1038/s41467-023-40064-9 | |||
| 1353 | 1911 | 93 | None | -6918 | 83 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| 3559 | 1911 | 93 | None | -6918 | 83 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| 86 | 1911 | 93 | None | -6918 | 83 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL54 | 1911 | 93 | None | -6918 | 83 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00502 | 1911 | 93 | None | -6918 | 83 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| 11980903 | 14492 | 19 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 22526 | 14492 | 19 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5281035 | 14492 | 19 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201303 | 14492 | 19 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5564 | 206006 | 118 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 288 | 2 | 1 | 2 | 5.1 | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL849 | 206006 | 118 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 288 | 2 | 1 | 2 | 5.1 | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl | 10.1038/s41467-023-40064-9 | |||
| 3899 | 207774 | 119 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 270 | 2 | 1 | 3 | 3.3 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL960 | 207774 | 119 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 270 | 2 | 1 | 3 | 3.3 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1038/s41467-023-40064-9 | |||
| 24826799 | 10798 | 104 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 532 | 4 | 1 | 6 | 4.5 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1171837 | 10798 | 104 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 532 | 4 | 1 | 6 | 4.5 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | 10.1038/s41467-023-40064-9 | |||
| 2335 | 11848 | 22 | None | - | 12 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 8478 | 11848 | 22 | None | - | 12 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1182210 | 11848 | 22 | None | - | 12 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL221753 | 11848 | 22 | None | - | 12 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 2585 | 803 | 103 | None | - | 21 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| 522 | 803 | 103 | None | - | 21 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| 551 | 803 | 103 | None | - | 21 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL723 | 803 | 103 | None | - | 21 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| DB01136 | 803 | 103 | None | - | 21 | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 16220172 | 73043 | 95 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 392 | 2 | 3 | 3 | 5.1 | CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2010601 | 73043 | 95 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 392 | 2 | 3 | 3 | 5.1 | CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O | 10.1038/s41467-023-40064-9 | |||
| 3926 | 207241 | 40 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 491 | 9 | 1 | 3 | 5.8 | Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL92870 | 207241 | 40 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 491 | 9 | 1 | 3 | 5.8 | Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 54585 | 14502 | 85 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 357 | 7 | 4 | 6 | 2.7 | O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201346 | 14502 | 85 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 357 | 7 | 4 | 6 | 2.7 | O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 2812 | 4779 | 101 | None | - | 34 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL104 | 4779 | 101 | None | - | 34 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| 11626560 | 200937 | 94 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 449 | 5 | 2 | 6 | 5.0 | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL601719 | 200937 | 94 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 449 | 5 | 2 | 6 | 5.0 | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | 10.1038/s41467-023-40064-9 | |||
| 47472 | 19437 | 57 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 410 | 7 | 0 | 3 | 6.6 | Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1295 | 19437 | 57 | None | - | 0 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 410 | 7 | 0 | 3 | 6.6 | Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| 16362 | 3125 | 71 | None | - | 30 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| 2172 | 3125 | 71 | None | - | 30 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| 90 | 3125 | 71 | None | - | 30 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1423 | 3125 | 71 | None | - | 30 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| DB01100 | 3125 | 71 | None | - | 30 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| 392622 | 56312 | 95 | None | - | 4 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL163 | 56312 | 95 | None | - | 4 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 | 10.1038/s41467-023-40064-9 | |||
| 4485 | 69379 | 118 | None | - | 8 | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 346 | 4 | 1 | 7 | 2.2 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] | 10.1038/s41467-023-40064-9 | |||
| CHEMBL193 | 69379 | 118 | None | - | 8 | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 346 | 4 | 1 | 7 | 2.2 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] | 10.1038/s41467-023-40064-9 | |||
| 53232 | 188625 | 95 | None | - | 2 | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 4.2 | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL503 | 188625 | 95 | None | - | 2 | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 4.2 | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| 1037 | 1578 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 1578 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 1578 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 588 | 1578 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| DB00876 | 1578 | 69 | None | - | 1 | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5329102 | 194726 | 86 | None | - | 0 | Human | 5.4 | pAC50 | = | 5.4 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL535 | 194726 | 86 | None | - | 0 | Human | 5.4 | pAC50 | = | 5.4 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
| 1037 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 588 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| DB00876 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 1037 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 588 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| DB00876 | 1578 | 69 | None | - | 1 | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 2855 | 4132 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| 3322 | 4132 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| 5717 | 4132 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL603 | 4132 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| DB00549 | 4132 | 104 | None | - | 6 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| 3333 | 40168 | 111 | None | - | 1 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 383 | 4 | 1 | 5 | 4.0 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1480 | 40168 | 111 | None | - | 1 | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 383 | 4 | 1 | 5 | 4.0 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl | 10.1038/s41467-023-40064-9 | |||
| 41684 | 31221 | 105 | None | - | 0 | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1401 | 31221 | 105 | None | - | 0 | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
| 146015366 | 208402 | 79 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| 60852 | 208402 | 79 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL997 | 208402 | 79 | None | - | 0 | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| 275196 | 125673 | 52 | None | - | 0 | Human | 6.2 | pAC50 | = | 6.2 | Binding | ChEMBL | 413 | 4 | 0 | 8 | 2.9 | COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL364713 | 125673 | 52 | None | - | 0 | Human | 6.2 | pAC50 | = | 6.2 | Binding | ChEMBL | 413 | 4 | 0 | 8 | 2.9 | COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C | 10.1038/s41467-023-40064-9 | |||
| 4494 | 190187 | 87 | None | - | 0 | Human | 4.2 | pAC50 | = | 4.2 | Binding | ChEMBL | 385 | 5 | 1 | 8 | 2.5 | COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL517427 | 190187 | 87 | None | - | 0 | Human | 4.2 | pAC50 | = | 4.2 | Binding | ChEMBL | 385 | 5 | 1 | 8 | 2.5 | COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 | 10.1038/s41467-023-40064-9 | |||
| 5282219 | 35869 | 63 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 450 | 12 | 1 | 5 | 5.7 | CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1441961 | 35869 | 63 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 450 | 12 | 1 | 5 | 5.7 | CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 | 10.1038/s41467-023-40064-9 | |||
| 135565674 | 194844 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 213023 | 194844 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 6445226 | 194844 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 9578572 | 194844 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL539697 | 194844 | 102 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 4209 | 3163 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 4893 | 3163 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 503 | 3163 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 5385 | 3163 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2 | 3163 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| DB00457 | 3163 | 75 | None | - | 33 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 5282181 | 53523 | 60 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 400 | 6 | 2 | 2 | 6.6 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1601669 | 53523 | 60 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 400 | 6 | 2 | 2 | 6.6 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL5314356 | 194597 | 0 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | |||||
| 135564886 | 14493 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 135673376 | 14493 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 137157436 | 14493 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 145948239 | 14493 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 71587099 | 14493 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201304 | 14493 | 5 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 2194 | 63083 | 101 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 240 | 2 | 0 | 4 | 4.2 | COc1ccc(-c2cc(=S)ss2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL178862 | 63083 | 101 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 240 | 2 | 0 | 4 | 4.2 | COc1ccc(-c2cc(=S)ss2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 71329 | 179269 | 102 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 441 | 11 | 2 | 6 | 2.0 | CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL473 | 179269 | 102 | None | - | 0 | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 441 | 11 | 2 | 6 | 2.0 | CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 | 10.1038/s41467-023-40064-9 | |||
| 155540547 | 172521 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4483576 | 172521 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155539027 | 172824 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4514079 | 172824 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155541295 | 173011 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4518318 | 173011 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155547844 | 173698 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4535678 | 173698 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155565112 | 175499 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4577692 | 175499 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155546362 | 173551 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4532075 | 173551 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568289 | 176127 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4592000 | 176127 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155557139 | 174544 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4556070 | 174544 | 0 | None | - | 0 | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155520024 | 173246 | 0 | None | - | 0 | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524570 | 173246 | 0 | None | - | 0 | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155557139 | 174544 | 0 | None | - | 0 | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4556070 | 174544 | 0 | None | - | 0 | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||||
| 155544988 | 173442 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| CHEMBL4529051 | 173442 | 0 | None | - | 0 | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| 155541440 | 173019 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| CHEMBL4518530 | 173019 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| 155540033 | 172890 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| CHEMBL4515768 | 172890 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| 155541125 | 172965 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| CHEMBL4517561 | 172965 | 0 | None | - | 1 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| 155540470 | 172476 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4482867 | 172476 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155559120 | 174786 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4561769 | 174786 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155564502 | 175260 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4572408 | 175260 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 54696627 | 98346 | 0 | None | - | 0 | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 486 | 5 | 2 | 7 | 5.0 | Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL27511 | 98346 | 0 | None | - | 0 | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 486 | 5 | 2 | 7 | 5.0 | Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1016/S0960-894X(01)81134-3 | |||
| 54726669 | 99270 | 0 | None | - | 0 | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 461 | 5 | 2 | 6 | 4.6 | O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL281887 | 99270 | 0 | None | - | 0 | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 461 | 5 | 2 | 6 | 4.6 | O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 | 10.1016/S0960-894X(01)81134-3 | |||
| 155539027 | 172824 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4514079 | 172824 | 0 | None | - | 0 | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155547428 | 173615 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4533618 | 173615 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155550799 | 174274 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4549405 | 174274 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155543091 | 173180 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 173180 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155520014 | 173236 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524300 | 173236 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL2028943 | 209135 | 0 | None | - | 0 | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||||
| CHEMBL2370909 | 209948 | 0 | None | - | 0 | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||||
| 155542907 | 173177 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| CHEMBL4522038 | 173177 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| 155563676 | 175344 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4574199 | 175344 | 0 | None | - | 0 | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL2392353 | 210414 | 6 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 3082475 | 3877 | 16 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 6902 | 3877 | 16 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4297447 | 3877 | 16 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| DB12199 | 3877 | 16 | None | - | 1 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155568804 | 176120 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4591857 | 176120 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155541240 | 173016 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4518420 | 173016 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155563538 | 175300 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| CHEMBL4573250 | 175300 | 0 | None | - | 0 | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| 155554529 | 174633 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4557984 | 174633 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 10533900 | 175969 | 8 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| CHEMBL4588454 | 175969 | 8 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| 155544246 | 173366 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4527484 | 173366 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155553003 | 174076 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4544308 | 174076 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| 155561477 | 175192 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4570840 | 175192 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155562469 | 175221 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| CHEMBL4571382 | 175221 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| 155553930 | 175441 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4576650 | 175441 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155551279 | 173987 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 877 | 29 | 13 | 12 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| CHEMBL4542269 | 173987 | 0 | None | - | 0 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 877 | 29 | 13 | 12 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| 3082475 | 3877 | 16 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 6902 | 3877 | 16 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4297447 | 3877 | 16 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| DB12199 | 3877 | 16 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 70538373 | 175498 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4577691 | 175498 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| 155554865 | 174354 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4551317 | 174354 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 54726671 | 94623 | 0 | None | - | 0 | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 471 | 5 | 2 | 6 | 5.3 | O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL25226 | 94623 | 0 | None | - | 0 | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 471 | 5 | 2 | 6 | 5.3 | O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155560095 | 174922 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4564950 | 174922 | 0 | None | - | 0 | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155563538 | 175300 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| CHEMBL4573250 | 175300 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| 155565687 | 175583 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4579604 | 175583 | 0 | None | - | 0 | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155556507 | 174486 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4554466 | 174486 | 0 | None | - | 0 | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 54726670 | 93964 | 0 | None | - | 0 | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 491 | 7 | 2 | 5 | 6.2 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL24842 | 93964 | 0 | None | - | 0 | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 491 | 7 | 2 | 5 | 6.2 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155560463 | 175040 | 0 | None | - | 0 | Rat | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| CHEMBL4567667 | 175040 | 0 | None | - | 0 | Rat | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| 155553003 | 174076 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4544308 | 174076 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| 155554865 | 174354 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4551317 | 174354 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155564502 | 175260 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4572408 | 175260 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155560463 | 175040 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| CHEMBL4567667 | 175040 | 0 | None | - | 0 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| 155551762 | 174010 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4542709 | 174010 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155552995 | 174112 | 0 | None | - | 0 | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4545399 | 174112 | 0 | None | - | 0 | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155556530 | 174511 | 0 | None | - | 0 | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4555119 | 174511 | 0 | None | - | 0 | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| 155568109 | 176039 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590381 | 176039 | 0 | None | - | 0 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL2392353 | 210414 | 6 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155556530 | 174511 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4555119 | 174511 | 0 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| 11944 | 3876 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155552190 | 3876 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4544228 | 3876 | 0 | None | - | 1 | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155540470 | 172476 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4482867 | 172476 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155553311 | 174133 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 174133 | 0 | None | - | 0 | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 154573825 | 175989 | 9 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4588946 | 175989 | 9 | None | - | 0 | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| 54726676 | 99227 | 0 | None | - | 0 | Bovine | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 501 | 6 | 2 | 7 | 5.3 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL28162 | 99227 | 0 | None | - | 0 | Bovine | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 501 | 6 | 2 | 7 | 5.3 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155540328 | 172901 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| CHEMBL4516066 | 172901 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| 155547428 | 173615 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4533618 | 173615 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 176102 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 176102 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155559827 | 174915 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4564617 | 174915 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155565112 | 175499 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4577692 | 175499 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155558784 | 174776 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4561366 | 174776 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155540639 | 172933 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4516768 | 172933 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155553479 | 174178 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4547423 | 174178 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155558428 | 174729 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4560224 | 174729 | 0 | None | - | 0 | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155553479 | 174178 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4547423 | 174178 | 0 | None | - | 0 | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155543972 | 175015 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4567103 | 175015 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155567790 | 176053 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590589 | 176053 | 0 | None | - | 0 | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155556507 | 174486 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4554466 | 174486 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 130762 | 98247 | 9 | None | - | 0 | Bovine | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL274447 | 98247 | 9 | None | - | 0 | Bovine | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155568109 | 176039 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590381 | 176039 | 0 | None | - | 0 | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL77838 | 215878 | 5 | None | - | 0 | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O | nan | |||||
| 155558428 | 174729 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4560224 | 174729 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155560095 | 174922 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4564950 | 174922 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155548506 | 173754 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4536886 | 173754 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| 155569246 | 176183 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4593310 | 176183 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155568804 | 176120 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4591857 | 176120 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155568318 | 176102 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 176102 | 0 | None | - | 0 | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155543091 | 173180 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 173180 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155550799 | 174274 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4549405 | 174274 | 0 | None | - | 0 | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155540639 | 172933 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4516768 | 172933 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155544988 | 173442 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| CHEMBL4529051 | 173442 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| 155565687 | 175583 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4579604 | 175583 | 0 | None | - | 0 | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 155563973 | 175361 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 941 | 27 | 14 | 13 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4574655 | 175361 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 941 | 27 | 14 | 13 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155541295 | 173011 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4518318 | 173011 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 145925550 | 175472 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 903 | 24 | 13 | 12 | -2.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4577270 | 175472 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 903 | 24 | 13 | 12 | -2.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155539838 | 172895 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 172895 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 11943 | 3875 | 0 | None | - | 1 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 145925549 | 3875 | 0 | None | - | 1 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4438122 | 3875 | 0 | None | - | 1 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155540033 | 172890 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| CHEMBL4515768 | 172890 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| 155520014 | 173236 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524300 | 173236 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL312754 | 211110 | 18 | None | - | 0 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||||
| 155548506 | 173754 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4536886 | 173754 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| 155548148 | 173715 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4535997 | 173715 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155554529 | 174633 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4557984 | 174633 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155566196 | 175746 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4583284 | 175746 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155558003 | 174693 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4559421 | 174693 | 0 | None | - | 0 | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 70538373 | 175498 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4577691 | 175498 | 0 | None | - | 0 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| 154573825 | 175989 | 9 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4588946 | 175989 | 9 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| 155561477 | 175192 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4570840 | 175192 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155559104 | 174806 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4562270 | 174806 | 0 | None | - | 0 | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155552475 | 174052 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4543860 | 174052 | 0 | None | - | 0 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155560024 | 174890 | 0 | None | - | 0 | Rat | 4.4 | pEC50 | = | 4.4 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4564094 | 174890 | 0 | None | - | 0 | Rat | 4.4 | pEC50 | = | 4.4 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 11943 | 3875 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00435 | |||||
| 145925549 | 3875 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00435 | |||||
| CHEMBL4438122 | 3875 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00435 | |||||
| 11943 | 3875 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 145925549 | 3875 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4438122 | 3875 | 0 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155542907 | 173177 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| CHEMBL4522038 | 173177 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| 155541125 | 172965 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| CHEMBL4517561 | 172965 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| 155552475 | 174052 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4543860 | 174052 | 0 | None | - | 0 | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155561376 | 175675 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | |||
| CHEMBL4581718 | 175675 | 0 | None | - | 0 | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | |||
| 155560024 | 174890 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4564094 | 174890 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155553098 | 174110 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4545153 | 174110 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155553311 | 174133 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 174133 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155540547 | 172521 | 0 | None | - | 0 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4483576 | 172521 | 0 | None | - | 0 | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155548148 | 173715 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4535997 | 173715 | 0 | None | - | 0 | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155551762 | 174010 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4542709 | 174010 | 0 | None | - | 0 | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155546362 | 173551 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4532075 | 173551 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553930 | 175441 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4576650 | 175441 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 54726675 | 99374 | 0 | None | - | 0 | Bovine | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 5.7 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL282566 | 99374 | 0 | None | - | 0 | Bovine | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 5.7 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155558003 | 174693 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4559421 | 174693 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 86727577 | 115976 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 422 | 2 | 1 | 5 | 3.6 | C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 | 10.1021/jm5013006 | |||
| CHEMBL3355127 | 115976 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 422 | 2 | 1 | 5 | 3.6 | C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 | 10.1021/jm5013006 | |||
| 155555310 | 174359 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4551431 | 174359 | 0 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155555310 | 174359 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4551431 | 174359 | 0 | None | - | 0 | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 10533900 | 175969 | 8 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| CHEMBL4588454 | 175969 | 8 | None | - | 0 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| 90219582 | 115977 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 436 | 2 | 1 | 5 | 3.9 | Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 | 10.1021/jm5013006 | |||
| CHEMBL3355137 | 115977 | 0 | None | - | 0 | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 436 | 2 | 1 | 5 | 3.9 | Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 | 10.1021/jm5013006 | |||
| 155552995 | 174112 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4545399 | 174112 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL77838 | 215878 | 5 | None | - | 0 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O | nan | |||||
| 16133225 | 419 | 52 | None | - | 4 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 172198 | 419 | 52 | None | - | 4 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 2504 | 419 | 52 | None | - | 4 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 45266664 | 419 | 52 | None | - | 4 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 5272 | 419 | 52 | None | - | 4 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL408403 | 419 | 52 | None | - | 4 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| DB11842 | 419 | 52 | None | - | 4 | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 54726672 | 99307 | 0 | None | - | 0 | Bovine | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 517 | 6 | 2 | 7 | 6.0 | CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL282082 | 99307 | 0 | None | - | 0 | Bovine | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 517 | 6 | 2 | 7 | 6.0 | CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 54726668 | 97245 | 0 | None | - | 0 | Bovine | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 477 | 5 | 2 | 7 | 5.3 | O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL26875 | 97245 | 0 | None | - | 0 | Bovine | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 477 | 5 | 2 | 7 | 5.3 | O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155559827 | 174915 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4564617 | 174915 | 0 | None | - | 0 | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155539838 | 172895 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 172895 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155547844 | 173698 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4535678 | 173698 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553098 | 174110 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4545153 | 174110 | 0 | None | - | 0 | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155566196 | 175746 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4583284 | 175746 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155567790 | 176053 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590589 | 176053 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155562469 | 175221 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| CHEMBL4571382 | 175221 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| 155568289 | 176127 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4592000 | 176127 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155544246 | 173366 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4527484 | 173366 | 0 | None | - | 0 | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155520024 | 173246 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524570 | 173246 | 0 | None | - | 0 | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155558784 | 174776 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4561366 | 174776 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155543972 | 175015 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4567103 | 175015 | 0 | None | - | 0 | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL938 | 215907 | 28 | None | - | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||||
| 155552886 | 174096 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4544902 | 174096 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155552886 | 174096 | 0 | None | - | 0 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4544902 | 174096 | 0 | None | - | 0 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 145925550 | 175472 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 903 | 24 | 13 | 12 | -2.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4577270 | 175472 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 903 | 24 | 13 | 12 | -2.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155559104 | 174806 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4562270 | 174806 | 0 | None | - | 0 | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155541240 | 173016 | 0 | None | - | 0 | Rat | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4518420 | 173016 | 0 | None | - | 0 | Rat | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL2028943 | 209135 | 0 | None | - | 0 | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||||
| 155552429 | 174157 | 0 | None | - | 0 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4546799 | 174157 | 0 | None | - | 0 | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155540328 | 172901 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| CHEMBL4516066 | 172901 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| 155563676 | 175344 | 0 | None | - | 0 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4574199 | 175344 | 0 | None | - | 0 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155559120 | 174786 | 0 | None | - | 0 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4561769 | 174786 | 0 | None | - | 0 | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL2370909 | 209948 | 0 | None | - | 0 | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||||
| 155552429 | 174157 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4546799 | 174157 | 0 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL312754 | 211110 | 18 | None | - | 0 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||||
| 155541440 | 173019 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| CHEMBL4518530 | 173019 | 0 | None | - | 0 | Rat | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| 16133225 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 172198 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 2504 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 45266664 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 5272 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL408403 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| DB11842 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 54726674 | 99730 | 0 | None | - | 0 | Bovine | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 5.9 | CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL284877 | 99730 | 0 | None | - | 0 | Bovine | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 5.9 | CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 | 10.1016/S0960-894X(01)81134-3 | |||
| 11944 | 3876 | 0 | None | - | 1 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155552190 | 3876 | 0 | None | - | 1 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| CHEMBL4544228 | 3876 | 0 | None | - | 1 | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | None | None | None | None | nan | |||||
| 155558059 | 174683 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4559239 | 174683 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | |||
| 155569246 | 176183 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4593310 | 176183 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 54726673 | 99223 | 0 | None | - | 0 | Bovine | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 477 | 6 | 2 | 5 | 5.8 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL28160 | 99223 | 0 | None | - | 0 | Bovine | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 477 | 6 | 2 | 5 | 5.8 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 10032858 | 29761 | 0 | None | - | 0 | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL138690 | 29761 | 0 | None | - | 0 | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10032858 | 29761 | 0 | None | - | 0 | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL138690 | 29761 | 0 | None | - | 0 | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9895212 | 119640 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL346728 | 119640 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 10417251 | 96905 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL265797 | 96905 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10417251 | 96905 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL265797 | 96905 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10417251 | 96905 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL265797 | 96905 | 0 | None | - | 0 | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10349732 | 118753 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341828 | 118753 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 10032820 | 117304 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339672 | 117304 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10032820 | 117304 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339672 | 117304 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10349732 | 118753 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL341828 | 118753 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10032820 | 117304 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339672 | 117304 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10439848 | 119210 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343309 | 119210 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10439848 | 119210 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343309 | 119210 | 0 | None | - | 0 | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10010071 | 117349 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339722 | 117349 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 9829012 | 92556 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL24322 | 92556 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44311455 | 102744 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305017 | 102744 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311580 | 102779 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305238 | 102779 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311676 | 103061 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307318 | 103061 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311435 | 204022 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL69721 | 204022 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311415 | 204085 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70161 | 204085 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311434 | 204124 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70370 | 204124 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311072 | 204186 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70789 | 204186 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311073 | 204200 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70843 | 204200 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311414 | 204223 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70935 | 204223 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9829012 | 92556 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL24322 | 92556 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 73347893 | 92626 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435828 | 92626 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9829012 | 92556 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24322 | 92556 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19754061 | 102734 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL304947 | 102734 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| 44309719 | 203854 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68638 | 203854 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10010071 | 117349 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 117349 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9829012 | 92556 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL24322 | 92556 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 9829012 | 92556 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | |||
| CHEMBL24322 | 92556 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | |||
| 9809961 | 107161 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL316300 | 107161 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10439862 | 118772 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341934 | 118772 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10010195 | 119184 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343142 | 119184 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 9809961 | 107161 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL316300 | 107161 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9917295 | 102958 | 17 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL306407 | 102958 | 17 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 9809961 | 107161 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316300 | 107161 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 9809961 | 107161 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL316300 | 107161 | 2 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10439862 | 118772 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341934 | 118772 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10010195 | 119184 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343142 | 119184 | 0 | None | - | 0 | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10395394 | 31880 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL140708 | 31880 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10032851 | 16835 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL124771 | 16835 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 9809637 | 203852 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68618 | 203852 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10032851 | 16835 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL124771 | 16835 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10395394 | 31880 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL140708 | 31880 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210588 | 120345 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353037 | 120345 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032851 | 16835 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL124771 | 16835 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10327309 | 113891 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL332576 | 113891 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1007/s00044-011-9815-x | |||
| 10395335 | 117082 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339256 | 117082 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10372451 | 117294 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339605 | 117294 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10327309 | 113891 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332576 | 113891 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| 10395335 | 117082 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 117082 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10372451 | 117294 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339605 | 117294 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10372093 | 112762 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330533 | 112762 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | |||
| 44314822 | 102949 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306362 | 102949 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10259411 | 30658 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139452 | 30658 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10485116 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL338101 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 10462598 | 114136 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL332909 | 114136 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| 10485116 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338101 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10395076 | 168576 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL435811 | 168576 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10462598 | 114136 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332909 | 114136 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| 10485116 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338101 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10395076 | 168576 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL435811 | 168576 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10395076 | 168576 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL435811 | 168576 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259411 | 30658 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139452 | 30658 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10485116 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL338101 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10462598 | 114136 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL332909 | 114136 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| 10485116 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338101 | 116853 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10395076 | 168576 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL435811 | 168576 | 0 | None | - | 0 | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19939453 | 112391 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL329679 | 112391 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10326797 | 207574 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94905 | 207574 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | |||
| 44381724 | 120308 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352771 | 120308 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381671 | 120427 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353800 | 120427 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10259395 | 26995 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL136465 | 26995 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10078663 | 207787 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL96075 | 207787 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 9853391 | 116839 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338027 | 116839 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101608 | 117029 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339004 | 117029 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10078663 | 207787 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96075 | 207787 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9853391 | 116839 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338027 | 116839 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101608 | 117029 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339004 | 117029 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10009273 | 107225 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316706 | 107225 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10259395 | 26995 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL136465 | 26995 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10078663 | 207787 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL96075 | 207787 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 44327716 | 107314 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 492 | 10 | 2 | 5 | 6.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL317343 | 107314 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 492 | 10 | 2 | 5 | 6.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| 9853391 | 116839 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338027 | 116839 | 1 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101608 | 117029 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339004 | 117029 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101284 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL93907 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10372659 | 118090 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL340632 | 118090 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101284 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL93907 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| 54693559 | 204540 | 2 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 425 | 4 | 2 | 8 | 3.0 | Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1021/jm0204237 | |||
| CHEMBL72838 | 204540 | 2 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 425 | 4 | 2 | 8 | 3.0 | Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1021/jm0204237 | |||
| 10101284 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL93907 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10372659 | 118090 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL340632 | 118090 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101284 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL93907 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| 10417351 | 207958 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97075 | 207958 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 44327912 | 208135 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | |||
| CHEMBL98068 | 208135 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | |||
| 10101284 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL93907 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381413 | 120722 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354779 | 120722 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10101284 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL93907 | 207402 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| 10372659 | 118090 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL340632 | 118090 | 0 | None | - | 0 | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10327537 | 116677 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL337118 | 116677 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10327537 | 116677 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL337118 | 116677 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210586 | 59012 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169221 | 59012 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381527 | 59074 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169568 | 59074 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10462933 | 16882 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125008 | 16882 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 76333473 | 84905 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL2236976 | 84905 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10462933 | 16882 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125008 | 16882 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44348523 | 113179 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL331450 | 113179 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10078397 | 12109 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1184032 | 12109 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329290 | 12109 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| 44315351 | 104885 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311160 | 104885 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44314823 | 161886 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL415073 | 161886 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44381427 | 120273 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352503 | 120273 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10462933 | 16882 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125008 | 16882 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 76333473 | 84905 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL2236976 | 84905 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10439837 | 16353 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122917 | 16353 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10462683 | 113282 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331507 | 113282 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44311289 | 102225 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302964 | 102225 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311456 | 102298 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL303427 | 102298 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311715 | 103196 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL308323 | 103196 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311074 | 104900 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311253 | 104900 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311412 | 105329 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311625 | 105329 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311581 | 167833 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL430792 | 167833 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311582 | 204208 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70868 | 204208 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9918412 | 204262 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71172 | 204262 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311413 | 204351 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71639 | 204351 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311753 | 204611 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL73283 | 204611 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 133031 | 100859 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL293511 | 100859 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 19939756 | 5038 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL105199 | 5038 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 133031 | 100859 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL293511 | 100859 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 44335530 | 107509 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL318605 | 107509 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 133031 | 100859 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL293511 | 100859 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | |||
| 10439837 | 16353 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122917 | 16353 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10462683 | 113282 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331507 | 113282 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44377058 | 120006 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350121 | 120006 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10349512 | 208007 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97332 | 208007 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44314761 | 102854 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305647 | 102854 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9853391 | 116839 | 1 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | |||
| CHEMBL338027 | 116839 | 1 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | |||
| 133031 | 100859 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL293511 | 100859 | 21 | None | - | 1 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 10439837 | 16353 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122917 | 16353 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10462683 | 113282 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331507 | 113282 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10010234 | 98427 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL275552 | 98427 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10100951 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL334300 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 9987614 | 168573 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL435792 | 168573 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10100951 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL334300 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 10259468 | 118481 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL341369 | 118481 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10390872 | 116146 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL335778 | 116146 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | |||
| 10100951 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL334300 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 10259468 | 118481 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL341369 | 118481 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9895635 | 112023 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328941 | 112023 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | |||
| 10010234 | 98427 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL275552 | 98427 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10100951 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL334300 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 9987614 | 168573 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL435792 | 168573 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381402 | 59165 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169967 | 59165 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10100951 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL334300 | 115044 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 10259468 | 118481 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL341369 | 118481 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101606 | 15771 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122273 | 15771 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259447 | 16928 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125280 | 16928 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| 10101606 | 15771 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122273 | 15771 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259447 | 16928 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125280 | 16928 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| 10326942 | 112394 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329693 | 112394 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | |||
| 10417102 | 207446 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94145 | 207446 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | |||
| 10101606 | 15771 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122273 | 15771 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259447 | 16928 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125280 | 16928 | 0 | None | - | 0 | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| 10033136 | 16073 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122380 | 16073 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10033136 | 16073 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122380 | 16073 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315078 | 204756 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74556 | 204756 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10033136 | 16073 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122380 | 16073 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10009984 | 113180 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331455 | 113180 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10440144 | 116894 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338342 | 116894 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10009984 | 113180 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331455 | 113180 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10440144 | 116894 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338342 | 116894 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 15292113 | 96033 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL259843 | 96033 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 204749 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74476 | 204749 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 204749 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL74476 | 204749 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | |||
| 44381657 | 59058 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169488 | 59058 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 9895984 | 204749 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL74476 | 204749 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10009984 | 113180 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331455 | 113180 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10440144 | 116894 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338342 | 116894 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10372497 | 118746 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341783 | 118746 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10259657 | 119393 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344597 | 119393 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10259489 | 16918 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1007/s00044-011-9815-x | |||
| CHEMBL125231 | 16918 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1007/s00044-011-9815-x | |||
| 19939418 | 108270 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL319730 | 108270 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10395335 | 117082 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 117082 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10259489 | 16918 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| CHEMBL125231 | 16918 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| 10372497 | 118746 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341783 | 118746 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10259657 | 119393 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344597 | 119393 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210589 | 58596 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168413 | 58596 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381403 | 59166 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169968 | 59166 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44210585 | 120407 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353615 | 120407 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10010207 | 30195 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139041 | 30195 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10078780 | 116916 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338433 | 116916 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10439819 | 169889 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL444065 | 169889 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19754068 | 102733 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL304946 | 102733 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10078780 | 116916 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338433 | 116916 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10439819 | 169889 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL444065 | 169889 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10416475 | 207704 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95579 | 207704 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | |||
| 10010207 | 30195 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139041 | 30195 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210590 | 58714 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168490 | 58714 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10439715 | 117035 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339040 | 117035 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44309938 | 204300 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71388 | 204300 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10028545 | 21005 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL131156 | 21005 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | |||
| 10439715 | 117035 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339040 | 117035 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10055534 | 157461 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL407919 | 157461 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 9875044 | 208029 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97446 | 208029 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10439715 | 117035 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339040 | 117035 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 11765560 | 15537 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121872 | 15537 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9987414 | 117049 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339113 | 117049 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19430442 | 204175 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70726 | 204175 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 11765560 | 15537 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121872 | 15537 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9987414 | 117049 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339113 | 117049 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10100951 | 115044 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL334300 | 115044 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 11765560 | 15537 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121872 | 15537 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9987414 | 117049 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339113 | 117049 | 0 | None | - | 0 | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 9810305 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL276674 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 9810305 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL276674 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 9810305 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL276674 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9810305 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL276674 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 9810305 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL276674 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 9810305 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL276674 | 98572 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 10439993 | 119256 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343634 | 119256 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44311675 | 102154 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302579 | 102154 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311537 | 102332 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL303647 | 102332 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311454 | 102945 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306340 | 102945 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311185 | 104191 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309790 | 104191 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311752 | 104865 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311018 | 104865 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311736 | 204207 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70867 | 204207 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311557 | 204283 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71286 | 204283 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73353934 | 92622 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435824 | 92622 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00050a002 | |||
| 10326972 | 112261 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329099 | 112261 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | |||
| 133031 | 100859 | 21 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL293511 | 100859 | 21 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44300826 | 198738 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58291 | 198738 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44372744 | 52151 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | |||
| CHEMBL158795 | 52151 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | |||
| 9807029 | 203104 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL63998 | 203104 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a001 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a001 | |||
| 44384389 | 129837 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL367569 | 129837 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 10439993 | 119256 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343634 | 119256 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 19102786 | 207189 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL92533 | 207189 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 9939191 | 98946 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10032583 | 12349 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1185398 | 12349 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL411487 | 12349 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| 10054708 | 107154 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316273 | 107154 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| 10462598 | 114136 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332909 | 114136 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| 10032820 | 117304 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339672 | 117304 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 44381552 | 120287 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352629 | 120287 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 9917399 | 102146 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL302519 | 102146 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 9939191 | 98946 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 9917399 | 102146 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | |||
| CHEMBL302519 | 102146 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 44381553 | 120336 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352947 | 120336 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 136052288 | 124484 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 568 | 8 | 1 | 8 | 5.2 | CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640122 | 124484 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 568 | 8 | 1 | 8 | 5.2 | CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 10101351 | 168664 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL436396 | 168664 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 71652854 | 89156 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337686 | 89156 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2366020 | 89156 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 10101351 | 168664 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL436396 | 168664 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19430462 | 102984 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306638 | 102984 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.ejmech.2013.01.044 | |||||
| 14971698 | 207293 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| CHEMBL93226 | 207293 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| 10101351 | 168664 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL436396 | 168664 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032342 | 208022 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97394 | 208022 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | |||
| 44381426 | 120272 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352502 | 120272 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10101351 | 168664 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL436396 | 168664 | 0 | None | - | 0 | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10373120 | 117601 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340078 | 117601 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10373120 | 117601 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340078 | 117601 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 19939398 | 107334 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317547 | 107334 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10372718 | 108557 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | |||
| CHEMBL320222 | 108557 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | |||
| 10259447 | 16928 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125280 | 16928 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| 44381656 | 120268 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352458 | 120268 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10373120 | 117601 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340078 | 117601 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10440203 | 118987 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL342492 | 118987 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 11765454 | 118068 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340473 | 118068 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44310069 | 203738 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67801 | 203738 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 11765454 | 118068 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340473 | 118068 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10349597 | 111618 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328434 | 111618 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | |||
| 10440203 | 118987 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342492 | 118987 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 11765454 | 118068 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340473 | 118068 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10259525 | 15619 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122158 | 15619 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10349897 | 114428 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL333224 | 114428 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101690 | 116861 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338137 | 116861 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10010071 | 117349 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 117349 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259525 | 15619 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122158 | 15619 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10349897 | 114428 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL333224 | 114428 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101690 | 116861 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338137 | 116861 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259525 | 15619 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122158 | 15619 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10349897 | 114428 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL333224 | 114428 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101690 | 116861 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338137 | 116861 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44328276 | 112727 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330464 | 112727 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 44381622 | 59021 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169279 | 59021 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44311619 | 103070 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307359 | 103070 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311683 | 105618 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL312301 | 105618 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311453 | 204037 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL69839 | 204037 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 16133225 | 419 | 52 | None | -2 | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 172198 | 419 | 52 | None | -2 | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 2504 | 419 | 52 | None | -2 | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 45266664 | 419 | 52 | None | -2 | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 5272 | 419 | 52 | None | -2 | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| CHEMBL408403 | 419 | 52 | None | -2 | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| DB11842 | 419 | 52 | None | -2 | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm031100t | |||||
| 183134 | 204844 | 17 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 73347892 | 92621 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435823 | 92621 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 16133225 | 419 | 52 | None | - | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 172198 | 419 | 52 | None | - | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 2504 | 419 | 52 | None | - | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 45266664 | 419 | 52 | None | - | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 5272 | 419 | 52 | None | - | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| CHEMBL408403 | 419 | 52 | None | - | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| DB11842 | 419 | 52 | None | - | 4 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm7011563 | |||||
| 183134 | 204844 | 17 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2016.03.006 | |||||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2016.11.014 | |||||
| 10394995 | 111394 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327191 | 111394 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | |||
| 10326775 | 112239 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329089 | 112239 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | |||
| 10010047 | 207951 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97020 | 207951 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | |||
| 10439819 | 169889 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL444065 | 169889 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44384870 | 60046 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL173643 | 60046 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10010311 | 30527 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139325 | 30527 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10417144 | 32980 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL141592 | 32980 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10462573 | 117009 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338889 | 117009 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10032988 | 116917 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 116917 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10462573 | 117009 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338889 | 117009 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10078132 | 107251 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316904 | 107251 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | |||
| 10010311 | 30527 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139325 | 30527 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10417144 | 32980 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL141592 | 32980 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10462573 | 117009 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338889 | 117009 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 11765541 | 119008 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL342605 | 119008 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10032988 | 116917 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338434 | 116917 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10032988 | 116917 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 116917 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10077743 | 207957 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97068 | 207957 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | |||
| 11765541 | 119008 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342605 | 119008 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10032988 | 116917 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338434 | 116917 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9939191 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1007/s00044-013-0831-x | |||
| 9939191 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 9939191 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| 9939191 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10349659 | 111543 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327988 | 111543 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | |||
| 10395335 | 117082 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 117082 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10259468 | 118481 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL341369 | 118481 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9939191 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| 9852499 | 120463 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354080 | 120463 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032877 | 15549 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121907 | 15549 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259841 | 16158 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122401 | 16158 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9827346 | 99737 | 4 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL284918 | 99737 | 4 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL34866 | 99737 | 4 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 10032877 | 15549 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121907 | 15549 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259841 | 16158 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122401 | 16158 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372451 | 117294 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339605 | 117294 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032877 | 15549 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121907 | 15549 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259841 | 16158 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122401 | 16158 | 0 | None | - | 0 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9830680 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL292150 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 9830680 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL292150 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9830680 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL292150 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10009984 | 113180 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331455 | 113180 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9830680 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | |||
| CHEMBL292150 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | |||
| 9830680 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL292150 | 100643 | 0 | None | - | 1 | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 44312565 | 204771 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| CHEMBL74767 | 204771 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| 44348153 | 117970 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | |||
| CHEMBL340367 | 117970 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | |||
| 72548703 | 161567 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| CHEMBL4128926 | 161567 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| 10009968 | 112547 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329942 | 112547 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| 10480309 | 16378 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122969 | 16378 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10007362 | 17317 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125725 | 17317 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44311182 | 103027 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307008 | 103027 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311452 | 204505 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72595 | 204505 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9940350 | 204758 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74573 | 204758 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44275095 | 95177 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25585 | 95177 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44309704 | 204278 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71253 | 204278 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 9939191 | 98946 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44379268 | 120054 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL350554 | 120054 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44377125 | 55639 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL162148 | 55639 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10032851 | 16835 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL124771 | 16835 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 11765177 | 117008 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338888 | 117008 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 19939753 | 203754 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67921 | 203754 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 11765177 | 117008 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338888 | 117008 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 11765177 | 117008 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338888 | 117008 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 44315144 | 96592 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263191 | 96592 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10439858 | 16861 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL124903 | 16861 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 18950609 | 16405 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | |||
| CHEMBL123084 | 16405 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | |||
| 10439858 | 16861 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL124903 | 16861 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10439858 | 16861 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL124903 | 16861 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a033 | |||
| 44315282 | 96624 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263452 | 96624 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 14971639 | 114132 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| CHEMBL332897 | 114132 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| 9939191 | 98946 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10101608 | 117029 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339004 | 117029 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44381425 | 120454 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353980 | 120454 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032193 | 119145 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL342843 | 119145 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10394829 | 119360 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344387 | 119360 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10417321 | 15618 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122157 | 15618 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10417321 | 15618 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122157 | 15618 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10438745 | 107216 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316655 | 107216 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | |||
| 10258694 | 112587 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330165 | 112587 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10010071 | 117349 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 117349 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032193 | 119145 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342843 | 119145 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10394829 | 119360 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344387 | 119360 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10417321 | 15618 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122157 | 15618 | 0 | None | - | 0 | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 19430475 | 204252 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71125 | 204252 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9874508 | 204680 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL73876 | 204680 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9874508 | 204680 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | |||
| CHEMBL73876 | 204680 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | |||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2010.07.034 | |||||
| 44274855 | 96942 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 564 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26614 | 96942 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 564 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 9960852 | 107182 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316482 | 107182 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 10030110 | 16250 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122443 | 16250 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10256602 | 16866 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124925 | 16866 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10052399 | 118468 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341295 | 118468 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44311617 | 102539 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL304065 | 102539 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311618 | 163337 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL419073 | 163337 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 19430479 | 204269 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71220 | 204269 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311184 | 204421 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72099 | 204421 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311558 | 204722 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74236 | 204722 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2013.03.016 | |||||
| 44309902 | 103117 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL307757 | 103117 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44309703 | 172554 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL448476 | 172554 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44309903 | 204394 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71925 | 204394 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10010027 | 208032 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97465 | 208032 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44309903 | 204394 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL71925 | 204394 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 10372810 | 106202 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL313868 | 106202 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 15292111 | 204745 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74442 | 204745 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10485202 | 119420 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344811 | 119420 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10485202 | 119420 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344811 | 119420 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 1952 | 2209 | 4 | None | - | 2 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| 5312129 | 2209 | 4 | None | - | 2 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| CHEMBL1182768 | 2209 | 4 | None | - | 2 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| 9874086 | 109113 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321367 | 109113 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10439715 | 117035 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339040 | 117035 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10457566 | 202802 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62269 | 202802 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44282952 | 120429 | 0 | None | - | 1 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 511 | 7 | 2 | 8 | 3.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL35381 | 120429 | 0 | None | - | 1 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 511 | 7 | 2 | 8 | 3.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||||
| 10350378 | 208199 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98453 | 208199 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | |||
| 10028460 | 116521 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL336180 | 116521 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | |||
| 10009478 | 112472 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329858 | 112472 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | |||
| 2541 | 786 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 587 | 786 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 6907 | 786 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1016 | 786 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB00796 | 786 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB13919 | 786 | 120 | None | -1 | 6 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 10414338 | 17964 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126111 | 17964 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9824776 | 119365 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL344407 | 119365 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 60148656 | 92627 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435829 | 92627 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9824776 | 119365 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL344407 | 119365 | 0 | None | - | 0 | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 15292113 | 96033 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL259843 | 96033 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10349801 | 107938 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319353 | 107938 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10417431 | 109108 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321363 | 109108 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | |||
| 10101606 | 15771 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122273 | 15771 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 16133225 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 172198 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 2504 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 45266664 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 5272 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL408403 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| DB11842 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 15292112 | 102948 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306361 | 102948 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 14956763 | 163397 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL419483 | 163397 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 19430458 | 204074 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70100 | 204074 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 18950608 | 15671 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122224 | 15671 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | |||
| 10032361 | 112726 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330463 | 112726 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | |||
| 9987414 | 117049 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339113 | 117049 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44275095 | 95177 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25585 | 95177 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 18950586 | 15564 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122017 | 15564 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | |||
| 9986299 | 158451 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL409058 | 158451 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | |||
| 10349392 | 208050 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97557 | 208050 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | |||
| 10372659 | 118090 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL340632 | 118090 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 135955119 | 124491 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640129 | 124491 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 53321879 | 57597 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1667998 | 57597 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44315304 | 205010 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL76821 | 205010 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 73349224 | 92193 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 11 | 4.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL2425239 | 92193 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 11 | 4.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1 | 10.1007/s00044-013-0831-x | |||
| 14956757 | 67593 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL19018 | 67593 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 14956757 | 67593 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL19018 | 67593 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | |||
| 14956757 | 67593 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL19018 | 67593 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | |||
| 44311538 | 102963 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306435 | 102963 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311183 | 204700 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74069 | 204700 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311735 | 204752 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74514 | 204752 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 15076146 | 106976 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL315104 | 106976 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 9914666 | 116670 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL337086 | 116670 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | |||
| 44272246 | 98789 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 628 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL278305 | 98789 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 628 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44272247 | 98863 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL278977 | 98863 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 15076146 | 106976 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL315104 | 106976 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44310586 | 172647 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL449648 | 172647 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 10483888 | 111455 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327563 | 111455 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | |||
| 10416501 | 112410 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329759 | 112410 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10483726 | 207576 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94910 | 207576 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| 183134 | 204844 | 17 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9961192 | 11366 | 43 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179743 | 11366 | 43 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97688 | 11366 | 43 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10078554 | 116968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338687 | 116968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10078554 | 116968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338687 | 116968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10010125 | 208031 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97464 | 208031 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10078554 | 116968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338687 | 116968 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 44275096 | 94755 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc(N(C)C(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25315 | 94755 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc(N(C)C(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10259265 | 110043 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 110043 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10259265 | 110043 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL323506 | 110043 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10077497 | 11369 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179757 | 11369 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98426 | 11369 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| 11765560 | 15537 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121872 | 15537 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44314761 | 102854 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305647 | 102854 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10394712 | 119377 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344467 | 119377 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 14956739 | 206302 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87074 | 206302 | 0 | None | - | 1 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10394712 | 119377 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344467 | 119377 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381528 | 58993 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169009 | 58993 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032877 | 15549 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121907 | 15549 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44314823 | 161886 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL415073 | 161886 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10484866 | 31785 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL140619 | 31785 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 9984181 | 118448 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341131 | 118448 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277573 | 99541 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL283495 | 99541 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44277871 | 99700 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28464 | 99700 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 192626 | 15659 | 14 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | |||
| CHEMBL122212 | 15659 | 14 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | |||
| 1481 | 2066 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 3749 | 2066 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 589 | 2066 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 6908 | 2066 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL1513 | 2066 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| DB01029 | 2066 | 116 | None | - | 3 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 44285267 | 148448 | 33 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.4 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39379 | 148448 | 33 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.4 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44274731 | 100067 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL287184 | 100067 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 70682146 | 76331 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058860 | 76331 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10078800 | 109191 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 109191 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44311635 | 102224 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL302959 | 102224 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | |||
| 10032988 | 116917 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 116917 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44385182 | 61074 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL176473 | 61074 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10484866 | 31785 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL140619 | 31785 | 0 | None | - | 0 | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10372550 | 164516 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL421478 | 164516 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10372550 | 164516 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL421478 | 164516 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372550 | 164516 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL421478 | 164516 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 145946921 | 167600 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337687 | 167600 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337688 | 167600 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL4300967 | 167600 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44314780 | 103078 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307430 | 103078 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 14956772 | 105947 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL312913 | 105947 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9830839 | 106931 | 0 | None | - | 2 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL314812 | 106931 | 0 | None | - | 2 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | |||
| 10078780 | 116916 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338433 | 116916 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10373120 | 117601 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340078 | 117601 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 44381739 | 58785 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168771 | 58785 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44274854 | 94317 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.1 | CCCCc1nc2ccc(OC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25056 | 94317 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.1 | CCCCc1nc2ccc(OC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274731 | 100067 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL287184 | 100067 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10055448 | 30763 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139582 | 30763 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 136052335 | 124487 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 622 | 8 | 1 | 8 | 5.8 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4cccc(F)c4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| CHEMBL3640125 | 124487 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 622 | 8 | 1 | 8 | 5.8 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4cccc(F)c4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| 136052364 | 124490 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 608 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640128 | 124490 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 608 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 135876075 | 124493 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 624 | 9 | 1 | 11 | 5.6 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3F)c2=O)cc1 | nan | |||
| CHEMBL3640131 | 124493 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 624 | 9 | 1 | 11 | 5.6 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3F)c2=O)cc1 | nan | |||
| 11755602 | 168447 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 497 | 9 | 1 | 9 | 3.6 | CCCCc1nc2ccn(CC(=O)OC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL43500 | 168447 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 497 | 9 | 1 | 9 | 3.6 | CCCCc1nc2ccn(CC(=O)OC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 44311754 | 102997 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306761 | 102997 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311071 | 103415 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL308482 | 103415 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 3036053 | 101333 | 13 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL296725 | 101333 | 13 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 10322211 | 169472 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL442963 | 169472 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1016/j.bmc.2010.10.043 | |||
| 15818748 | 99913 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL286134 | 99913 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 9850811 | 154740 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39996 | 154740 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 19939454 | 207557 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL94793 | 207557 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 3036053 | 101333 | 13 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL296725 | 101333 | 13 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 9851889 | 102074 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | |||
| 3036053 | 101333 | 13 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL296725 | 101333 | 13 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 44289008 | 164864 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL42200 | 164864 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 10417031 | 107386 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317864 | 107386 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10439253 | 112321 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329255 | 112321 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | |||
| 10439837 | 16353 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122917 | 16353 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44348523 | 113179 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL331450 | 113179 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10462683 | 113282 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331507 | 113282 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9851082 | 101020 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| CHEMBL294512 | 101020 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| 44381739 | 58785 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL168771 | 58785 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm701575k | |||||
| 10055448 | 30763 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139582 | 30763 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 1037 | 1578 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 3940 | 1578 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 5281037 | 1578 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 588 | 1578 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| DB00876 | 1578 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 14952924 | 197930 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL57309 | 197930 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1 | 10.1016/S0960-894X(01)81116-1 | |||
| 136052282 | 124488 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 8 | 1 | 9 | 5.2 | O=C(Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(F)cc1 | nan | |||
| CHEMBL3640126 | 124488 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 8 | 1 | 9 | 5.2 | O=C(Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(F)cc1 | nan | |||
| 136052259 | 124494 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1cccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2=O)c1 | nan | |||
| CHEMBL3640132 | 124494 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1cccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2=O)c1 | nan | |||
| 44277676 | 99319 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 613 | 11 | 0 | 9 | 6.1 | CCCCCN(C(=O)c1ccccc1OC)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282167 | 99319 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 613 | 11 | 0 | 9 | 6.1 | CCCCCN(C(=O)c1ccccc1OC)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10028209 | 101417 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 482 | 9 | 2 | 8 | 2.9 | CCCCc1nc2ccn(CC(N)=O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL297358 | 101417 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 482 | 9 | 2 | 8 | 2.9 | CCCCc1nc2ccn(CC(N)=O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 3936 | 2210 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 6603900 | 2210 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL288174 | 2210 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 44274692 | 96446 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26217 | 96446 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 9955424 | 165124 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL422756 | 165124 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 127034873 | 136449 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735744 | 136449 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44379183 | 120815 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL355708 | 120815 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10461785 | 11923 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1182712 | 11923 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL262296 | 11923 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| 10348847 | 112589 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330170 | 112589 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10484119 | 168108 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL432822 | 168108 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10054188 | 207521 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94582 | 207521 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10462933 | 16882 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125008 | 16882 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 3936 | 2210 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| 6603900 | 2210 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| CHEMBL288174 | 2210 | 35 | None | 1 | 4 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| 44381670 | 120484 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354298 | 120484 | 0 | None | - | 0 | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10392378 | 16518 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123671 | 16518 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10325267 | 16863 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 550 | 12 | 1 | 9 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124913 | 16863 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 550 | 12 | 1 | 9 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956757 | 67593 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL19018 | 67593 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 136052261 | 124486 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 618 | 8 | 1 | 8 | 5.9 | Cc1ccc(CCn2c(=O)c3cc(CC(F)(F)F)sc3n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2=O)cc1 | nan | |||
| CHEMBL3640124 | 124486 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 618 | 8 | 1 | 8 | 5.9 | Cc1ccc(CCn2c(=O)c3cc(CC(F)(F)F)sc3n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2=O)cc1 | nan | |||
| 136052281 | 124492 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1ccccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3noc(O)n3)cc2)c1=O | nan | |||
| CHEMBL3640130 | 124492 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1ccccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3noc(O)n3)cc2)c1=O | nan | |||
| 136052251 | 124503 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 7 | 1 | 9 | 4.5 | CCc1cc2c(=O)n(CC(=O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640140 | 124503 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 7 | 1 | 9 | 4.5 | CCc1cc2c(=O)n(CC(=O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052396 | 124521 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 610 | 6 | 1 | 9 | 5.7 | CCc1cc2c(=O)n(-c3ccc4c(c3)CC(C)(C)O4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640158 | 124521 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 610 | 6 | 1 | 9 | 5.7 | CCc1cc2c(=O)n(-c3ccc4c(c3)CC(C)(C)O4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052283 | 124522 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 7 | 1 | 9 | 4.8 | CC(C)(C)C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| CHEMBL3640159 | 124522 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 7 | 1 | 9 | 4.8 | CC(C)(C)C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| 44277677 | 99320 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282168 | 99320 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 18950598 | 15542 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | |||
| CHEMBL121891 | 15542 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | |||
| 73355475 | 92625 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435827 | 92625 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 14956757 | 67593 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL19018 | 67593 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 14956779 | 68663 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL19202 | 68663 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10078048 | 106880 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL314514 | 106880 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| 9986951 | 207767 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95955 | 207767 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | |||
| 44314822 | 102949 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306362 | 102949 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315058 | 70453 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL194608 | 70453 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9869504 | 208047 | 4 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL97533 | 208047 | 4 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| 44274673 | 93740 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24724 | 93740 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10254585 | 112904 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331042 | 112904 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 136052277 | 124516 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 656 | 10 | 1 | 11 | 5.3 | CCc1cc2c(=O)n(CC(OC(C)=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640153 | 124516 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 656 | 10 | 1 | 11 | 5.3 | CCc1cc2c(=O)n(CC(OC(C)=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 137662335 | 160835 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 593 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N\OC)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL4114708 | 160835 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 593 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N\OC)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 44277902 | 99794 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CC(=O)OCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28532 | 99794 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CC(=O)OCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44274673 | 93740 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24724 | 93740 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 1481 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| 3749 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| 589 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| 6908 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| CHEMBL1513 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| DB01029 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm00074a018 | |||
| 22574723 | 15938 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 7 | 5.2 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 | 10.1039/C4MD00499J | |||
| CHEMBL12233 | 15938 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 7 | 5.2 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 | 10.1039/C4MD00499J | |||
| 57380647 | 70354 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945010 | 70354 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 70686410 | 76330 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058859 | 76330 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 19939409 | 107160 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL316299 | 107160 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 1481 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| 3749 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| 589 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| 6908 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL1513 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| DB01029 | 2066 | 116 | None | -1 | 3 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)81139-2 | |||
| 10372341 | 168198 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL433375 | 168198 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | |||
| 10077929 | 207345 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL93606 | 207345 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | |||
| 10326460 | 208107 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97897 | 208107 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10009735 | 158205 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL408798 | 158205 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 76311803 | 84970 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 592 | 12 | 3 | 11 | 4.6 | CCCCc1nnc(SCc2ccccc2-c2nnn[nH]2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237602 | 84970 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 592 | 12 | 3 | 11 | 4.6 | CCCCc1nnc(SCc2ccccc2-c2nnn[nH]2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 9987311 | 116757 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL337588 | 116757 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10414470 | 17129 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125542 | 17129 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44320012 | 167923 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL431411 | 167923 | 0 | None | - | 1 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 136052301 | 124495 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 594 | 9 | 1 | 11 | 5.2 | CCc1cc2c(=O)n(CC(=O)c3ccccc3OC)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2s1 | nan | |||
| CHEMBL3640133 | 124495 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 594 | 9 | 1 | 11 | 5.2 | CCc1cc2c(=O)n(CC(=O)c3ccccc3OC)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2s1 | nan | |||
| 136052255 | 124499 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 684 | 9 | 1 | 10 | 5.6 | COc1ccccc1C(=O)Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2c(F)cc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| CHEMBL3640137 | 124499 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 684 | 9 | 1 | 10 | 5.6 | COc1ccccc1C(=O)Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2c(F)cc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| 136052247 | 124509 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 558 | 7 | 2 | 9 | 4.6 | CC(C)(C)C(O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| CHEMBL3640146 | 124509 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 558 | 7 | 2 | 9 | 4.6 | CC(C)(C)C(O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| 136052300 | 124518 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(F)c3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640155 | 124518 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(F)c3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3F)c2s1 | nan | |||
| 136052332 | 124526 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640162 | 124526 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052372 | 124530 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 564 | 8 | 1 | 9 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640166 | 124530 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 564 | 8 | 1 | 9 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052324 | 124532 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 570 | 8 | 1 | 10 | 4.8 | CCc1cc2c(=O)n(CC(=O)c3cccs3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640171 | 124532 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 570 | 8 | 1 | 10 | 4.8 | CCc1cc2c(=O)n(CC(=O)c3cccs3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 10481968 | 50694 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL157577 | 50694 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 15236320 | 172606 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL449095 | 172606 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 10054324 | 98353 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL275160 | 98353 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10099040 | 120241 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 10 | 5.0 | CCCCc1nnc(SCc2ccccc2-c2nn[nH]n2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL352236 | 120241 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 10 | 5.0 | CCCCc1nnc(SCc2ccccc2-c2nn[nH]n2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9852384 | 100416 | 5 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL290214 | 100416 | 5 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.9b01780 | |||
| 127035265 | 136536 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736514 | 136536 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10417195 | 109079 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321313 | 109079 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10054324 | 98353 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL275160 | 98353 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10101690 | 116861 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338137 | 116861 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9852384 | 100416 | 5 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| CHEMBL290214 | 100416 | 5 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| 44305410 | 162359 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL416507 | 162359 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 9987311 | 116757 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL337588 | 116757 | 0 | None | - | 0 | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10321941 | 138147 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL37679 | 138147 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| 19010048 | 84968 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237600 | 84968 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10327728 | 98122 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL273542 | 98122 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10369867 | 16377 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)cs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122966 | 16377 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)cs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 135876074 | 124489 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3F)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640127 | 124489 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3F)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052291 | 124505 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2=O)cc1 | nan | |||
| CHEMBL3640142 | 124505 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2=O)cc1 | nan | |||
| 136052286 | 124506 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 8 | 1 | 9 | 5.5 | O=C(Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)C1CCCCC1 | nan | |||
| CHEMBL3640143 | 124506 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 8 | 1 | 9 | 5.5 | O=C(Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)C1CCCCC1 | nan | |||
| 136052352 | 124508 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 573 | 8 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N/OC)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640145 | 124508 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 573 | 8 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N/OC)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052270 | 124512 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 602 | 10 | 1 | 11 | 4.0 | CCc1cc2c(=O)n(CC(=O)C(C)(C)COC(C)=O)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640149 | 124512 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 602 | 10 | 1 | 11 | 4.0 | CCc1cc2c(=O)n(CC(=O)C(C)(C)COC(C)=O)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052397 | 124514 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 1 | 10 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)s3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640151 | 124514 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 1 | 10 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)s3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052320 | 124515 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 9 | 2 | 10 | 4.7 | CCc1cc2c(=O)n(CC(O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640152 | 124515 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 9 | 2 | 10 | 4.7 | CCc1cc2c(=O)n(CC(O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052319 | 124527 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640163 | 124527 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052299 | 124529 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 570 | 8 | 1 | 9 | 5.0 | CCc1cc2c(=O)n(CC(=O)C3CCCCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640165 | 124529 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 570 | 8 | 1 | 9 | 5.0 | CCc1cc2c(=O)n(CC(=O)C3CCCCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00037a014 | |||
| 10481968 | 50694 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157577 | 50694 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9850834 | 154662 | 17 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| CHEMBL39959 | 154662 | 17 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| 44379292 | 120334 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352934 | 120334 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10327728 | 98122 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL273542 | 98122 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10438523 | 208144 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98126 | 208144 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| 11765454 | 118068 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340473 | 118068 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315144 | 96592 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263191 | 96592 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9851889 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44300838 | 198670 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL57976 | 198670 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9850834 | 154662 | 17 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| CHEMBL39959 | 154662 | 17 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| 9851889 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| 44211672 | 158206 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL408799 | 158206 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10327728 | 98122 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL273542 | 98122 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10484986 | 118697 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341715 | 118697 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 136052375 | 124485 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 638 | 8 | 1 | 8 | 6.3 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4ccc(Cl)cc4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| CHEMBL3640123 | 124485 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 638 | 8 | 1 | 8 | 6.3 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4ccc(Cl)cc4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| 136052302 | 124500 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| CHEMBL3640138 | 124500 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| 136052246 | 124501 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 9 | 1 | 10 | 5.2 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| CHEMBL3640139 | 124501 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 9 | 1 | 10 | 5.2 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| 136052258 | 124520 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.8 | CCc1cc2c(=O)n(-c3ccc(OC(C)C)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640157 | 124520 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.8 | CCc1cc2c(=O)n(-c3ccc(OC(C)C)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052298 | 124531 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 11 | 1 | 11 | 5.3 | CCO/N=C(/Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| CHEMBL3640167 | 124531 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 11 | 1 | 11 | 5.3 | CCO/N=C(/Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| 136052297 | 124534 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 578 | 8 | 1 | 8 | 5.8 | CCc1cc2c(=O)n(CC(C)(C)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640173 | 124534 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 578 | 8 | 1 | 8 | 5.8 | CCc1cc2c(=O)n(CC(C)(C)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1 | nan | |||
| 44277903 | 99118 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 10 | 0 | 9 | 5.0 | CCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280908 | 99118 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 10 | 0 | 9 | 5.0 | CCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 11764826 | 98284 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL274710 | 98284 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 15231091 | 93988 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24861 | 93988 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274823 | 99075 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL280526 | 99075 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 45102750 | 63778 | 4 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL1801740 | 63778 | 4 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 45102750 | 63778 | 4 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801740 | 63778 | 4 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 19754050 | 203880 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68786 | 203880 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 11764826 | 98284 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL274710 | 98284 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10233056 | 107159 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316297 | 107159 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | |||
| 10259525 | 15619 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122158 | 15619 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259841 | 16158 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122401 | 16158 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315351 | 104885 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311160 | 104885 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10484986 | 118697 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341715 | 118697 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10030086 | 16977 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125383 | 16977 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 136052394 | 124498 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640136 | 124498 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052399 | 124504 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 622 | 8 | 1 | 9 | 5.6 | CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640141 | 124504 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 622 | 8 | 1 | 9 | 5.6 | CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052347 | 124507 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 618 | 8 | 1 | 11 | 4.6 | CCc1cc2c(=O)n(CC(=O)c3nc4ccccc4n3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640144 | 124507 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 618 | 8 | 1 | 11 | 4.6 | CCc1cc2c(=O)n(CC(=O)c3nc4ccccc4n3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052345 | 124510 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 9 | 3.9 | CCc1cc2c(=O)n(CC3(C)COC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640147 | 124510 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 9 | 3.9 | CCc1cc2c(=O)n(CC3(C)COC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052268 | 124511 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 560 | 7 | 2 | 10 | 3.4 | CCc1cc2c(=O)n(CC3(O)CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640148 | 124511 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 560 | 7 | 2 | 10 | 3.4 | CCc1cc2c(=O)n(CC3(O)CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052310 | 124519 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 626 | 10 | 1 | 10 | 5.3 | CCCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640156 | 124519 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 626 | 10 | 1 | 10 | 5.3 | CCCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052379 | 124525 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 672 | 9 | 1 | 11 | 5.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3Br)c2s1 | nan | |||
| CHEMBL3640161 | 124525 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 672 | 9 | 1 | 11 | 5.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3Br)c2s1 | nan | |||
| 9851889 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 44277573 | 99541 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL283495 | 99541 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44277442 | 100297 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28917 | 100297 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277451 | 100906 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 601 | 10 | 0 | 8 | 6.3 | CCCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29386 | 100906 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 601 | 10 | 0 | 8 | 6.3 | CCCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44283174 | 100074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL287250 | 100074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9851889 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44310589 | 168098 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 488 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL432734 | 168098 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 488 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 9851889 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | |||
| 44377199 | 57419 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL165349 | 57419 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 9851889 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | |||
| 9801006 | 119729 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1021/jm9504722 | |||
| CHEMBL347610 | 119729 | 0 | None | - | 1 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1021/jm9504722 | |||
| 9851889 | 102074 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | |||
| 9851889 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00052a006 | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00052a006 | |||
| 10258916 | 29711 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL138654 | 29711 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 10010164 | 117397 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339806 | 117397 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9845644 | 206433 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87964 | 206433 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 136052351 | 124496 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 608 | 9 | 1 | 11 | 5.5 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3C)c2s1 | nan | |||
| CHEMBL3640134 | 124496 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 608 | 9 | 1 | 11 | 5.5 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3C)c2s1 | nan | |||
| 136052241 | 124497 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 3.3 | CCc1cc2c(=O)n(CCN3CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640135 | 124497 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 3.3 | CCc1cc2c(=O)n(CCN3CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052269 | 124513 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 7 | 2 | 9 | 4.3 | CCc1cc2c(=O)n(CC(O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640150 | 124513 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 7 | 2 | 9 | 4.3 | CCc1cc2c(=O)n(CC(O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052400 | 124528 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4cc(F)ccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640164 | 124528 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4cc(F)ccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136401533 | 160841 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 649 | 12 | 1 | 11 | 5.5 | C=CCO/N=C(\Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| CHEMBL4114807 | 160841 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 649 | 12 | 1 | 11 | 5.5 | C=CCO/N=C(\Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| 108185 | 1614 | 78 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00037a014 | |||
| 586 | 1614 | 78 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00037a014 | |||
| CHEMBL907 | 1614 | 78 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00037a014 | |||
| 10010164 | 117397 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339806 | 117397 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10100074 | 112560 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330007 | 112560 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 9810305 | 98572 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL276674 | 98572 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 10258916 | 29711 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL138654 | 29711 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 10010164 | 117397 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339806 | 117397 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10394859 | 17429 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL125760 | 17429 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9960721 | 16311 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 12 | 0 | 8 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122638 | 16311 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 12 | 0 | 8 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 59351471 | 124517 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 417 | 5 | 1 | 6 | 3.9 | CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3OC)c2s1 | nan | |||
| CHEMBL3640154 | 124517 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 417 | 5 | 1 | 6 | 3.9 | CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3OC)c2s1 | nan | |||
| 136052367 | 124533 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 648 | 8 | 1 | 10 | 5.6 | CCc1cc2c(=O)n(CC(=O)c3sccc3Br)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640172 | 124533 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 648 | 8 | 1 | 10 | 5.6 | CCc1cc2c(=O)n(CC(=O)c3sccc3Br)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 44277652 | 99824 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 8 | 0 | 8 | 5.5 | CCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28555 | 99824 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 8 | 0 | 8 | 5.5 | CCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 2806 | 3969 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| 3937 | 3969 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| 593 | 3969 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| 60846 | 3969 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| CHEMBL1069 | 3969 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| DB00177 | 3969 | 110 | None | - | 1 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm031100t | |||
| 10394859 | 17429 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL125760 | 17429 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44376746 | 119859 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL348758 | 119859 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10033136 | 16073 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122380 | 16073 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315078 | 204756 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74556 | 204756 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44303230 | 200647 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL59957 | 200647 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 10394859 | 17429 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL125760 | 17429 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 76308179 | 84975 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 584 | 12 | 3 | 9 | 4.1 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237607 | 84975 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 584 | 12 | 3 | 9 | 4.1 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10222835 | 206145 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86084 | 206145 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44459556 | 98731 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 6 | 1 | 6 | 4.6 | CCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL277902 | 98731 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 6 | 1 | 6 | 4.6 | CCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 19087866 | 98936 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL279515 | 98936 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44459544 | 99369 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2cccc(F)c2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL282526 | 99369 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2cccc(F)c2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44311428 | 102969 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306473 | 102969 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311543 | 104141 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309455 | 104141 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10069786 | 169101 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL439968 | 169101 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19008869 | 206414 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm031100t | |||
| CHEMBL87842 | 206414 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm031100t | |||
| 10325037 | 119787 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 541 | 11 | 2 | 8 | 4.5 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348143 | 119787 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 541 | 11 | 2 | 8 | 4.5 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73353933 | 92619 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435821 | 92619 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 70696780 | 76220 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 592 | 9 | 1 | 6 | 7.3 | CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058374 | 76220 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 592 | 9 | 1 | 6 | 7.3 | CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 19102815 | 207878 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96554 | 207878 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44311342 | 102181 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL302760 | 102181 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311450 | 104101 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309365 | 104101 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311688 | 104196 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309820 | 104196 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222101 | 158562 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL409170 | 158562 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311664 | 204163 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70638 | 204163 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311449 | 204480 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 549 | 10 | 2 | 9 | 3.9 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72409 | 204480 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 549 | 10 | 2 | 9 | 3.9 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15292111 | 204745 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74442 | 204745 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10100413 | 198590 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL57853 | 198590 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44300798 | 198955 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58499 | 198955 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9845644 | 206433 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87964 | 206433 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 9985329 | 22136 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 562 | 9 | 2 | 6 | 6.8 | CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL132226 | 22136 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 562 | 9 | 2 | 6 | 6.8 | CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 15287894 | 54947 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL16148 | 54947 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 10324361 | 16926 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 519 | 12 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccno2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125273 | 16926 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 519 | 12 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccno2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 16133225 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 172198 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 2504 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 45266664 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 5272 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| CHEMBL408403 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| DB11842 | 419 | 52 | None | -1 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | |||||
| 53309130 | 63772 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.6 | Cc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801734 | 63772 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.6 | Cc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 70690542 | 76221 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 9 | 1 | 6 | 6.6 | CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058375 | 76221 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 9 | 1 | 6 | 6.6 | CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 53309128 | 63782 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 6 | 1 | 4 | 6.4 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3C(=O)O)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801744 | 63782 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 6 | 1 | 4 | 6.4 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3C(=O)O)ccc21 | 10.1021/jm200409s | |||
| 44277549 | 99128 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280988 | 99128 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 2541 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 587 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 6907 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1016 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB00796 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB13919 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 76315368 | 84955 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 510 | 10 | 2 | 8 | 5.3 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237587 | 84955 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 510 | 10 | 2 | 8 | 5.3 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956760 | 165500 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL424053 | 165500 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44348352 | 16528 | 0 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL123713 | 16528 | 0 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/S0960-894X(01)80914-8 | |||
| 44285157 | 154705 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 5.2 | CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39978 | 154705 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 5.2 | CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10412300 | 48148 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 467 | 9 | 1 | 7 | 5.7 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155154 | 48148 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 467 | 9 | 1 | 7 | 5.7 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44311472 | 103792 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308943 | 103792 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 10500716 | 10228 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 392 | 8 | 2 | 4 | 4.5 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL116054 | 10228 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 392 | 8 | 2 | 4 | 4.5 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 9867446 | 169317 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.1 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL441649 | 169317 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.1 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44305424 | 102493 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304032 | 102493 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10434949 | 119642 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL346745 | 119642 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10456123 | 165317 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL423418 | 165317 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76310609 | 105248 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCn1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115244 | 105248 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCn1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44298831 | 194983 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 496 | 8 | 2 | 8 | 4.2 | CC(C)COc1nc2ccc(C(C)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL54699 | 194983 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 496 | 8 | 2 | 8 | 4.2 | CC(C)COc1nc2ccc(C(C)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10434949 | 119642 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346745 | 119642 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10456123 | 165317 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL423418 | 165317 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15654731 | 102193 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 482 | 9 | 1 | 8 | 4.9 | CCCOc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL302815 | 102193 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 482 | 9 | 1 | 8 | 4.9 | CCCOc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44305441 | 100945 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 388 | 5 | 1 | 7 | 2.0 | CCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL294075 | 100945 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 388 | 5 | 1 | 7 | 2.0 | CCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44341795 | 9944 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 516 | 6 | 1 | 3 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114625 | 9944 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 516 | 6 | 1 | 3 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1021/jm00074a018 | |||
| 15144937 | 18832 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 500 | 11 | 1 | 4 | 7.4 | CCCCc1ncc(/C=C(\Cc2cccc(Oc3ccccc3)c2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL128032 | 18832 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 500 | 11 | 1 | 4 | 7.4 | CCCCc1ncc(/C=C(\Cc2cccc(Oc3ccccc3)c2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 44303886 | 100880 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293660 | 100880 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44303852 | 102349 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL303755 | 102349 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 73346387 | 92630 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 497 | 7 | 1 | 5 | 5.2 | CCCc1nc2c(C)cc(C(=O)N3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435832 | 92630 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 497 | 7 | 1 | 5 | 5.2 | CCCc1nc2c(C)cc(C(=O)N3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9866104 | 203895 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 407 | 10 | 1 | 5 | 4.6 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL68919 | 203895 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 407 | 10 | 1 | 5 | 4.6 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a015 | |||
| 9850385 | 101692 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 8 | 1 | 8 | 5.2 | CCCCc1nc2ccc(C3=NN4CCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL299391 | 101692 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 8 | 1 | 8 | 5.2 | CCCCc1nc2ccc(C3=NN4CCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 11757908 | 117334 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 578 | 12 | 0 | 6 | 6.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc3ccccc3c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339709 | 117334 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 578 | 12 | 0 | 6 | 6.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc3ccccc3c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127034874 | 136405 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735333 | 136405 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44212049 | 101464 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 560 | 8 | 1 | 7 | 6.7 | CCCCc1nc2ccc(C3CCC4CCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL297714 | 101464 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 560 | 8 | 1 | 7 | 6.7 | CCCCc1nc2ccc(C3CCC4CCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44297113 | 101575 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 637 | 9 | 1 | 9 | 6.8 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccc(C)cc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL298560 | 101575 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 637 | 9 | 1 | 9 | 6.8 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccc(C)cc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 11388072 | 205832 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 634 | 9 | 1 | 9 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL83414 | 205832 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 634 | 9 | 1 | 9 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)NS(=O)(=O)c3ccc([N+](=O)[O-])cc3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 57380648 | 70374 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945148 | 70374 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127034876 | 136426 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735487 | 136426 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10453551 | 19098 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cccc(N)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL128913 | 19098 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cccc(N)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 24827768 | 159094 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 411 | 6 | 1 | 7 | 3.5 | CCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL409744 | 159094 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 411 | 6 | 1 | 7 | 3.5 | CCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 15356438 | 186860 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 425 | 9 | 2 | 5 | 4.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(=O)c2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48955 | 186860 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 425 | 9 | 2 | 5 | 4.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(=O)c2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| 10483230 | 46830 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154027 | 46830 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19939367 | 105950 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL312921 | 105950 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956792 | 106766 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314447 | 106766 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956754 | 157385 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL407827 | 157385 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277440 | 98962 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4cccnc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL279756 | 98962 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4cccnc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44307171 | 100922 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 481 | 5 | 2 | 5 | 4.7 | CCCc1nc2c(C)cc(C(=O)O)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL293926 | 100922 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 481 | 5 | 2 | 5 | 4.7 | CCCc1nc2c(C)cc(C(=O)O)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 11374350 | 206404 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 6.0 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL87779 | 206404 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 6.0 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 44373246 | 168267 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL433895 | 168267 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | |||
| 9824568 | 204413 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| CHEMBL72053 | 204413 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| 108185 | 1614 | 78 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00092a017 | |||
| 586 | 1614 | 78 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00092a017 | |||
| CHEMBL907 | 1614 | 78 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00092a017 | |||
| 10052777 | 48518 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 5.5 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155638 | 48518 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 5.5 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73355474 | 92617 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435819 | 92617 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 70696781 | 76222 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 7.5 | CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058376 | 76222 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 7.5 | CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 15236329 | 169334 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 598 | 6 | 1 | 7 | 6.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3Br)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL441837 | 169334 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 598 | 6 | 1 | 7 | 6.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3Br)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 10501285 | 163435 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 3.7 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL419762 | 163435 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 3.7 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44320817 | 106992 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 5.3 | CCCCc1nc(Cl)c2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL315219 | 106992 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 529 | 7 | 1 | 7 | 5.3 | CCCCc1nc(Cl)c2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O | 10.1016/S0960-894X(01)80290-0 | |||
| 44384871 | 129320 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL367095 | 129320 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| 11754522 | 22201 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 7 | 1 | 6 | 5.9 | CCCc1nc2ccc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL132282 | 22201 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 7 | 1 | 6 | 5.9 | CCCc1nc2ccc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10095637 | 49967 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15689 | 49967 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 19385665 | 51061 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15788 | 51061 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | |||
| 10053367 | 117246 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 553 | 12 | 0 | 7 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C#N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339480 | 117246 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 553 | 12 | 0 | 7 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C#N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10029695 | 158524 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 521 | 10 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL409136 | 158524 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 521 | 10 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9983135 | 168605 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 492 | 11 | 0 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2C=C(C)C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL435994 | 168605 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 492 | 11 | 0 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2C=C(C)C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL5271484 | 193686 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 315 | 3 | 1 | 4 | 2.8 | CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 44309702 | 203740 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67805 | 203740 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 9869504 | 208047 | 4 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL97533 | 208047 | 4 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| 76322689 | 84959 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237591 | 84959 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956796 | 205799 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL83182 | 205799 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44342013 | 9555 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 509 | 9 | 1 | 4 | 6.0 | CCCCC1=NC2(CCN(Cc3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL112343 | 9555 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 509 | 9 | 1 | 4 | 6.0 | CCCCC1=NC2(CCN(Cc3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19976676 | 206450 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3cccnc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL88067 | 206450 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3cccnc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 2541 | 786 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| 587 | 786 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| 6907 | 786 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1016 | 786 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| DB00796 | 786 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| DB13919 | 786 | 120 | None | -1 | 6 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| 2541 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| 587 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| 6907 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL1016 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| DB00796 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| DB13919 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| 2541 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 587 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 6907 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL1016 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| DB00796 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| DB13919 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 10006742 | 47922 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154949 | 47922 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9847539 | 182039 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47810 | 182039 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44297172 | 162218 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 587 | 8 | 2 | 10 | 2.9 | CCCCc1nc2ccc(C3=NN[C@H]4C(=O)N(C)C(=O)[C@@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL416296 | 162218 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 587 | 8 | 2 | 10 | 2.9 | CCCCc1nc2ccc(C3=NN[C@H]4C(=O)N(C)C(=O)[C@@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 10671263 | 9976 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 450 | 10 | 3 | 5 | 5.0 | CCCc1nc(C(O)(CC)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL114788 | 9976 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 450 | 10 | 3 | 5 | 5.0 | CCCc1nc(C(O)(CC)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10571686 | 10081 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 4.3 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL115392 | 10081 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 4.3 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 19939495 | 207825 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96314 | 207825 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 2541 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| 587 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| 6907 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| CHEMBL1016 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| DB00796 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| DB13919 | 786 | 120 | None | - | 6 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| 4110026 | 204935 | 1 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7632 | 204935 | 1 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 9886554 | 97106 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 387 | 8 | 2 | 5 | 3.9 | CCCCc1nc(CO)c(Cl)n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| CHEMBL267547 | 97106 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 387 | 8 | 2 | 5 | 3.9 | CCCCc1nc(CO)c(Cl)n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| 15699062 | 4927 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 376 | 7 | 2 | 4 | 3.6 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| CHEMBL104684 | 4927 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 376 | 7 | 2 | 4 | 3.6 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| 15699051 | 5773 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c(-c3nn[nH]n3)cccc12 | 10.1021/jm00114a021 | |||
| CHEMBL107862 | 5773 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c(-c3nn[nH]n3)cccc12 | 10.1021/jm00114a021 | |||
| 44293476 | 101961 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 500 | 12 | 3 | 6 | 4.7 | CCCCc1ncc(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL301328 | 101961 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 500 | 12 | 3 | 6 | 4.7 | CCCCc1ncc(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44307088 | 102203 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 465 | 4 | 1 | 6 | 3.8 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL302869 | 102203 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 465 | 4 | 1 | 6 | 3.8 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44295557 | 101776 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299980 | 101776 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792135 | 189503 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51399 | 189503 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15355267 | 193204 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52343 | 193204 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 4110026 | 204935 | 1 | None | - | 1 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7632 | 204935 | 1 | None | - | 1 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 53837978 | 170449 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL4448705 | 170449 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/acs.jmedchem.9b01780 | |||
| 44306628 | 203478 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 3 | 0 | 3 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)cc(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL66056 | 203478 | 0 | None | - | 0 | Rabbit | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 3 | 0 | 3 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)cc(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44295557 | 101776 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299980 | 101776 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792135 | 189503 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51399 | 189503 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15355267 | 193204 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52343 | 193204 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 127034905 | 136359 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734859 | 136359 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44293652 | 101428 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 11 | 2 | 7 | 5.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](c2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL297465 | 101428 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 11 | 2 | 7 | 5.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](c2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 24828714 | 96163 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.0 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc2c1=O | 10.1021/jm7011563 | |||
| CHEMBL260578 | 96163 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.0 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc2c1=O | 10.1021/jm7011563 | |||
| 14956759 | 206102 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85704 | 206102 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 73350990 | 92618 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 545 | 11 | 2 | 4 | 7.1 | CCCc1nc2c(C)cc(C(=O)NCCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435820 | 92618 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 545 | 11 | 2 | 4 | 7.1 | CCCc1nc2c(C)cc(C(=O)NCCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 19889359 | 160187 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL410939 | 160187 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 19889359 | 160187 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL410939 | 160187 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 10257293 | 16919 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(Cl)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125233 | 16919 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(Cl)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70690743 | 76635 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063981 | 76635 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 70690743 | 76635 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063981 | 76635 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 14950487 | 94606 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 401 | 6 | 2 | 6 | 3.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)O)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL25220 | 94606 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 401 | 6 | 2 | 6 | 3.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)O)c(C)n1 | 10.1021/jm00061a016 | |||
| 70688502 | 76328 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058857 | 76328 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 44459867 | 93885 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCCCc1nc2ccc(C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24802 | 93885 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCCCc1nc2ccc(C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44274710 | 99936 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL286260 | 99936 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 14956793 | 206308 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87129 | 206308 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956798 | 206409 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87798 | 206409 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 11397357 | 107014 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 6 | 1 | 7 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL315387 | 107014 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 6 | 1 | 7 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 9954408 | 207967 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL9714 | 207967 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 70684240 | 76223 | 0 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058377 | 76223 | 0 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44274710 | 99936 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL286260 | 99936 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19422649 | 101296 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 446 | 8 | 1 | 3 | 6.3 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL296492 | 101296 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 446 | 8 | 1 | 3 | 6.3 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44379347 | 120487 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL354338 | 120487 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44379291 | 120516 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL354535 | 120516 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 3081289 | 10024 | 11 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115021 | 10024 | 11 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44377075 | 119977 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349869 | 119977 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44315180 | 102896 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305956 | 102896 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 15292112 | 102948 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306361 | 102948 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 14951068 | 102105 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 475 | 12 | 2 | 8 | 3.5 | CCCCc1nn(CCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL302261 | 102105 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 475 | 12 | 2 | 8 | 3.5 | CCCCc1nn(CCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14951083 | 102606 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 509 | 11 | 1 | 8 | 4.7 | CCCCc1nn(CC(OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL304134 | 102606 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 509 | 11 | 1 | 8 | 4.7 | CCCCc1nn(CC(OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44270330 | 51746 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15847 | 51746 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 44270278 | 98864 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278983 | 98864 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL5272962 | 193741 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.7 | O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 10324657 | 113717 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 12 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332323 | 113717 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 12 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 46184983 | 86820 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.2 | CCc1nc2ccn(Cc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322437 | 86820 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.2 | CCc1nc2ccn(Cc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44295057 | 101334 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL296731 | 101334 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44295068 | 189020 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL50906 | 189020 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44274691 | 95567 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 583 | 9 | 2 | 8 | 4.9 | CCCCc1nc2ccc(NS(=O)(=O)C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25767 | 95567 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 583 | 9 | 2 | 8 | 4.9 | CCCCc1nc2ccc(NS(=O)(=O)C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19010044 | 84965 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237597 | 84965 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956742 | 206328 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87275 | 206328 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9984755 | 47952 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154975 | 47952 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10074143 | 48997 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.5 | CCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156070 | 48997 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.5 | CCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 44358304 | 116791 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 5 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3ccccc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL337787 | 116791 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 5 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3ccccc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 11754802 | 116519 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(Cl)cccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL336167 | 116519 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(Cl)cccc2n1 | 10.1021/jm00100a007 | |||
| 15231808 | 106001 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 5.1 | CCCCc1ncc2n1C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC=C2 | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL313239 | 106001 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 396 | 6 | 1 | 5 | 5.1 | CCCCc1ncc2n1C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC=C2 | 10.1016/S0960-894X(01)80290-0 | |||
| 14950499 | 99518 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 387 | 6 | 2 | 6 | 3.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL283372 | 99518 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 387 | 6 | 2 | 6 | 3.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c(C)n1 | 10.1021/jm00061a016 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 15654764 | 102705 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 5.1 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL304772 | 102705 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 5.1 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10181864 | 204298 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 7 | 4.4 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71384 | 204298 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 7 | 4.4 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 19385644 | 98751 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278061 | 98751 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10481742 | 120076 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL350697 | 120076 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44352156 | 168631 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 5.4 | CCSc1nc2c(C)scc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL436192 | 168631 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 5.4 | CCSc1nc2c(C)scc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 15780090 | 100455 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290669 | 100455 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10481742 | 120076 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL350697 | 120076 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792113 | 188220 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49930 | 188220 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| 10322185 | 19936 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 427 | 5 | 1 | 5 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(Cl)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL130275 | 19936 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 427 | 5 | 1 | 5 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(Cl)ccc2n1 | 10.1021/jm00100a007 | |||
| 10000936 | 20250 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2c(C)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130539 | 20250 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2c(C)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10250277 | 21593 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2cc(C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131722 | 21593 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2cc(C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 15696755 | 148023 | 1 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 306 | 7 | 1 | 3 | 3.6 | CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL39345 | 148023 | 1 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 306 | 7 | 1 | 3 | 3.6 | CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 24827771 | 96383 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.1 | CC(C)CCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL261765 | 96383 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.1 | CC(C)CCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 24828035 | 96921 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 3.9 | CCCCn1c(=O)c2ccc(NC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265958 | 96921 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 3.9 | CCCCn1c(=O)c2ccc(NC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 689043 | 36796 | 115 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 180 | 2 | 3 | 3 | 1.2 | O=C(O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL145 | 36796 | 115 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 180 | 2 | 3 | 3 | 1.2 | O=C(O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| 18655106 | 200469 | 0 | None | - | 0 | Rabbit | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL59854 | 200469 | 0 | None | - | 0 | Rabbit | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | |||
| 76310606 | 105244 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2cc(C(=O)NC(CC)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115236 | 105244 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2cc(C(=O)NC(CC)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 127036106 | 136368 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734949 | 136368 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44294022 | 186625 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 543 | 12 | 2 | 6 | 5.7 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C#N)c2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48798 | 186625 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 543 | 12 | 2 | 6 | 5.7 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C#N)c2)cc1 | 10.1021/jm00064a007 | |||
| 44275144 | 93662 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24688 | 93662 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44275144 | 93662 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24688 | 93662 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11340575 | 106983 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 7 | 2 | 6 | 5.9 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL315165 | 106983 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 7 | 2 | 6 | 5.9 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 11476484 | 206062 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL85405 | 206062 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 451 | 5 | 2 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 11351776 | 206210 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(NC)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86562 | 206210 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(NC)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 9896251 | 98773 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm020138n | |||
| CHEMBL278176 | 98773 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm020138n | |||
| 127034758 | 136370 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 681 | 12 | 1 | 8 | 7.7 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1039/C4MD00499J | |||
| CHEMBL3734968 | 136370 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 681 | 12 | 1 | 8 | 7.7 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1039/C4MD00499J | |||
| 9913391 | 51162 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(C)c(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157980 | 51162 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(C)c(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73357017 | 92629 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435831 | 92629 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 10027148 | 116653 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C)cccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337017 | 116653 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C)cccc2n1 | 10.1021/jm00100a007 | |||
| 44377262 | 57149 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 8 | 0 | 8 | 4.4 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL164617 | 57149 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 8 | 0 | 8 | 4.4 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10437270 | 107413 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 9 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL318042 | 107413 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 9 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00043a020 | |||
| 10416422 | 207999 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97295 | 207999 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10437261 | 117022 | 1 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 7 | 1 | 7 | 6.7 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL338954 | 117022 | 1 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 7 | 1 | 7 | 6.7 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 44404967 | 135418 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | |||
| CHEMBL372814 | 135418 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | |||
| 53309129 | 63771 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801714 | 63771 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 71521416 | 86828 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 6 | 1 | 8 | 5.1 | CCc1nc2ccn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322445 | 86828 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 6 | 1 | 8 | 5.1 | CCc1nc2ccn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76322690 | 84962 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237594 | 84962 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10055421 | 51408 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158188 | 51408 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 15698058 | 187123 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL49170 | 187123 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 14950501 | 85009 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 4.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22387 | 85009 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 4.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C)c(C)n1 | 10.1021/jm00061a016 | |||
| 15698058 | 187123 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL49170 | 187123 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15355266 | 194586 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL53074 | 194586 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44358503 | 27543 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 5 | 2 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3ccccc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL136911 | 27543 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 5 | 2 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3ccccc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 44288370 | 101120 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.5 | CCCCC1=NC(=O)C2(CCCC2)CN1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL295181 | 101120 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.5 | CCCCC1=NC(=O)C2(CCCC2)CN1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 10455118 | 116437 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 4 | 1 | 4 | 5.6 | Cc1cc(/C=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL336056 | 116437 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 4 | 1 | 4 | 5.6 | Cc1cc(/C=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 11757357 | 207992 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97273 | 207992 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 19792113 | 188220 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49930 | 188220 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| 15355266 | 194586 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL53074 | 194586 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792097 | 101629 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298950 | 101629 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15654717 | 102644 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL304360 | 102644 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 19792097 | 101629 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298950 | 101629 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 9894381 | 102040 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 574 | 8 | 1 | 7 | 7.0 | CCCCc1nc2ccc(C3CCC4CCCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301827 | 102040 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 574 | 8 | 1 | 7 | 7.0 | CCCCc1nc2ccc(C3CCC4CCCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 164625885 | 186266 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4873899 | 186266 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 73352461 | 92628 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 5.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435830 | 92628 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 5.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 127035247 | 136519 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736338 | 136519 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 19792093 | 101932 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL301072 | 101932 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10030665 | 48875 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155948 | 48875 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10369225 | 49010 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156084 | 49010 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956766 | 106979 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL315128 | 106979 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00074a018 | |||
| 10030665 | 48875 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155948 | 48875 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10369225 | 49010 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156084 | 49010 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10259265 | 110043 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 110043 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 15171393 | 85943 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 7 | 1 | 5 | 5.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(Cc2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL23006 | 85943 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 7 | 1 | 5 | 5.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(Cc2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 14950512 | 99827 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 511 | 7 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(CC)n1 | 10.1021/jm00061a016 | |||
| CHEMBL285560 | 99827 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 511 | 7 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(CC)n1 | 10.1021/jm00061a016 | |||
| 44305409 | 202810 | 0 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.8 | CCCc1cc(=O)n(CCNC(=O)C(c2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62314 | 202810 | 0 | None | - | 0 | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.8 | CCCc1cc(=O)n(CCNC(=O)C(c2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 19385623 | 50435 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15730 | 50435 | 0 | None | - | 0 | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10371118 | 15516 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 586 | 13 | 0 | 8 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121733 | 15516 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 586 | 13 | 0 | 8 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10415119 | 118084 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL340605 | 118084 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10030426 | 16621 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124144 | 16621 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 44315304 | 205010 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL76821 | 205010 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 76319035 | 84979 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 541 | 11 | 3 | 8 | 5.4 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237611 | 84979 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 541 | 11 | 3 | 8 | 5.4 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11511750 | 96555 | 1 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL262958 | 96555 | 1 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44294051 | 174959 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 604 | 14 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL45659 | 174959 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 604 | 14 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 | 10.1021/jm00064a007 | |||
| 44294031 | 183964 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 532 | 12 | 2 | 5 | 6.1 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48168 | 183964 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 532 | 12 | 2 | 5 | 6.1 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C)cc1 | 10.1021/jm00064a007 | |||
| 44341713 | 9731 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 515 | 7 | 1 | 4 | 4.9 | CCCCC1=NC2(CCN(C(=O)C(F)(F)F)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL113330 | 9731 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 515 | 7 | 1 | 4 | 4.9 | CCCCC1=NC2(CCN(C(=O)C(F)(F)F)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 15171409 | 206291 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccc(OC)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL87034 | 206291 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccc(OC)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44348042 | 16775 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL124449 | 16775 | 0 | None | - | 0 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| 127028595 | 137367 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753047 | 137367 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 9986861 | 119683 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 498 | 10 | 2 | 7 | 5.8 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347236 | 119683 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 498 | 10 | 2 | 7 | 5.8 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44438868 | 92004 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241684 | 92004 | 0 | None | - | 1 | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10412769 | 20251 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(Cl)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL130540 | 20251 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(Cl)c2n1 | 10.1021/jm00100a007 | |||
| 10049787 | 22466 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL132509 | 22466 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C)cc2n1 | 10.1021/jm00100a007 | |||
| 168288304 | 191371 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2cc(-c3oc4cc(O)cc(O)c4c(=O)c3O)ccc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| CHEMBL5192190 | 191371 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2cc(-c3oc4cc(O)cc(O)c4c(=O)c3O)ccc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| 168293707 | 192165 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2ccc(-c3oc4cc(O)cc(O)c4c(=O)c3O)cc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| CHEMBL5203983 | 192165 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2ccc(-c3oc4cc(O)cc(O)c4c(=O)c3O)cc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| 19385652 | 47518 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15458 | 47518 | 0 | None | - | 0 | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 10456700 | 119668 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347050 | 119668 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44459583 | 93274 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2c(C)cccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24499 | 93274 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2c(C)cccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 15699069 | 5090 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.2 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 | 10.1021/jm00114a021 | |||
| CHEMBL105525 | 5090 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.2 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 | 10.1021/jm00114a021 | |||
| 44285212 | 150461 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 546 | 7 | 1 | 5 | 6.3 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(c2ccccc2)=NC1(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39542 | 150461 | 1 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 546 | 7 | 1 | 5 | 6.3 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(c2ccccc2)=NC1(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10456700 | 119668 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347050 | 119668 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44563174 | 174420 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 536 | 7 | 1 | 5 | 8.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL455286 | 174420 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 536 | 7 | 1 | 5 | 8.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 19792093 | 101932 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL301072 | 101932 | 0 | None | - | 0 | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44303888 | 203279 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64674 | 203279 | 0 | None | - | 0 | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44298775 | 197648 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.1 | COc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL57090 | 197648 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.1 | COc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10620305 | 10108 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115560 | 10108 | 0 | None | - | 0 | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 73349423 | 92620 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 5.7 | CCCc1nc2c(C)cc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435822 | 92620 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 5.7 | CCCc1nc2c(C)cc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 24828294 | 95827 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 4.3 | CCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| CHEMBL258891 | 95827 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 4.3 | CCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| 44294052 | 101401 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 618 | 14 | 1 | 8 | 6.4 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL297265 | 101401 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 618 | 14 | 1 | 8 | 6.4 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2C)cc1 | 10.1021/jm00064a007 | |||
| 10347373 | 48536 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155661 | 48536 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11755714 | 120240 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL352235 | 120240 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956744 | 206163 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86255 | 206163 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44459896 | 96277 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2cc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26113 | 96277 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2cc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 10347373 | 48536 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155661 | 48536 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 11755714 | 120240 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL352235 | 120240 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44377263 | 164898 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 416 | 8 | 0 | 8 | 3.7 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL422200 | 164898 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 416 | 8 | 0 | 8 | 3.7 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10417195 | 109079 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321313 | 109079 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44315058 | 70453 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL194608 | 70453 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44372814 | 119790 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | |||
| CHEMBL348157 | 119790 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | |||
| 44320519 | 107173 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 7 | 1 | 7 | 4.6 | CCCCc1ncc2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL316392 | 107173 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 7 | 1 | 7 | 4.6 | CCCCc1ncc2n1[C@H](c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CC[C@@H]2N1C(=O)CCC1=O | 10.1016/S0960-894X(01)80290-0 | |||
| 44309299 | 102338 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 537 | 12 | 0 | 9 | 5.1 | CCCCc1nn(CC(OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL303683 | 102338 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 537 | 12 | 0 | 9 | 5.1 | CCCCc1nn(CC(OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 | 10.1021/jm00067a015 | |||
| 10223724 | 205757 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL82797 | 205757 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14951062 | 206391 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87669 | 206391 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10411441 | 51790 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15850 | 51790 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44381431 | 58501 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168346 | 58501 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 53309273 | 63775 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.6 | CCc1c(C)nc2c(nc(CC)n2[C@H]2CCc3cc(-c4ccccc4-c4nnn[nH]4)ccc32)c1C | 10.1021/jm200409s | |||
| CHEMBL1801737 | 63775 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.6 | CCc1c(C)nc2c(nc(CC)n2[C@H]2CCc3cc(-c4ccccc4-c4nnn[nH]4)ccc32)c1C | 10.1021/jm200409s | |||
| 10324179 | 114376 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333126 | 114376 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44342089 | 10045 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 442 | 7 | 0 | 6 | 4.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115193 | 10045 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 442 | 7 | 0 | 6 | 4.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1021/jm00074a018 | |||
| 44341702 | 10098 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 434 | 11 | 1 | 3 | 6.3 | CCCCC1=NC(CCC)(CCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115492 | 10098 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 434 | 11 | 1 | 3 | 6.3 | CCCCC1=NC(CCC)(CCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19976810 | 206354 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3cnccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL87411 | 206354 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3cnccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 19422654 | 101398 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 460 | 9 | 1 | 3 | 6.7 | CCCCC1=NC(C)(CC2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL297250 | 101398 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 460 | 9 | 1 | 3 | 6.7 | CCCCC1=NC(C)(CC2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44297010 | 101627 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL298943 | 101627 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 19102815 | 207878 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96554 | 207878 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44296547 | 188339 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 3 | 5 | 3.1 | CCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL50092 | 188339 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 3 | 5 | 3.1 | CCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 15654750 | 103596 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.5 | CSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL308651 | 103596 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.5 | CSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44563176 | 171444 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncn[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL446314 | 171444 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncn[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 19792183 | 101779 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299994 | 101779 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44210317 | 103211 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL308424 | 103211 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 14951055 | 204332 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 351 | 7 | 2 | 5 | 3.7 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL71518 | 204332 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 351 | 7 | 2 | 5 | 3.7 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a015 | |||
| 19792183 | 101779 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299994 | 101779 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 127034757 | 136395 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735265 | 136395 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 127036104 | 136470 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735910 | 136470 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127036294 | 136351 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734815 | 136351 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 24828567 | 96302 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 6 | 1 | 5 | 4.4 | CCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL261248 | 96302 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 6 | 1 | 5 | 4.4 | CCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44296953 | 194763 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3C4CCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53803 | 194763 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3C4CCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 127035514 | 136423 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735446 | 136423 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10094859 | 19990 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 8 | 1 | 4 | 5.8 | CCCc1nc2c(C)cc(CN(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130322 | 19990 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 8 | 1 | 4 | 5.8 | CCCc1nc2c(C)cc(CN(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10371295 | 113525 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 596 | 12 | 0 | 6 | 6.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(F)(F)F)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332152 | 113525 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 596 | 12 | 0 | 6 | 6.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(F)(F)F)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956745 | 206269 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86906 | 206269 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44307122 | 202996 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 349 | 3 | 1 | 4 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL63144 | 202996 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 349 | 3 | 1 | 4 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 9823146 | 19361 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL12909 | 19361 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | |||
| 127035410 | 136385 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 8 | 1 | 8 | 5.7 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| CHEMBL3735155 | 136385 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 8 | 1 | 8 | 5.7 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| 70692693 | 76215 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 8 | 1 | 6 | 6.1 | CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058369 | 76215 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 8 | 1 | 6 | 6.1 | CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44438880 | 91986 | 0 | None | - | 1 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241523 | 91986 | 0 | None | - | 1 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44297143 | 101251 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 547 | 8 | 1 | 8 | 5.3 | CCCCc1nc2ccc([C@@H]3[C@H]4CCCN3OC4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL296173 | 101251 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 547 | 8 | 1 | 8 | 5.3 | CCCCc1nc2ccc([C@@H]3[C@H]4CCCN3OC4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 9886863 | 33919 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL142380 | 33919 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 10078800 | 109191 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 109191 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 9886863 | 33919 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| CHEMBL142380 | 33919 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| 14951066 | 103059 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 9 | 1 | 9 | 3.6 | CCCCc1nn(CC(=O)OC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL307310 | 103059 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 9 | 1 | 9 | 3.6 | CCCCc1nn(CC(=O)OC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10183373 | 165010 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL422593 | 165010 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 19811543 | 203371 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 9 | 1 | 7 | 3.7 | CCCCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL65224 | 203371 | 0 | None | - | 0 | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 9 | 1 | 7 | 3.7 | CCCCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 19385586 | 49726 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15669 | 49726 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10049400 | 155440 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40381 | 155440 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44381603 | 59116 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169798 | 59116 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 10323969 | 16408 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 9 | 0 | 8 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(C)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123091 | 16408 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 9 | 0 | 8 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(C)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70682146 | 76331 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2058860 | 76331 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10325767 | 113074 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 13 | 0 | 8 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331219 | 113074 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 13 | 0 | 8 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 53309275 | 63777 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.8 | CCc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801739 | 63777 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.8 | CCc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 44306647 | 100904 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL293846 | 100904 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 127034756 | 136353 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734829 | 136353 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 15780064 | 99623 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL284123 | 99623 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 44438901 | 91987 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241529 | 91987 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10390316 | 22016 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(Cl)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL132115 | 22016 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(Cl)cc2n1 | 10.1021/jm00100a007 | |||
| 9984310 | 21080 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2cccc(NC(=O)NC3CCCCC3)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131209 | 21080 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2cccc(NC(=O)NC3CCCCC3)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10367325 | 168410 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 467 | 8 | 1 | 4 | 6.8 | CCCCc1nc2ccc(N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL434815 | 168410 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 467 | 8 | 1 | 4 | 6.8 | CCCCc1nc2ccc(N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 10096347 | 49415 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156449 | 49415 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44298758 | 194154 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2ccc(C)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL52824 | 194154 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2ccc(C)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44321129 | 111467 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 8 | 1 | 7 | 5.0 | CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL327614 | 111467 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 8 | 1 | 7 | 5.0 | CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC | 10.1016/S0960-894X(01)80290-0 | |||
| 10096347 | 49415 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156449 | 49415 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 54768660 | 65117 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824000 | 65117 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| 44309040 | 102987 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 7 | 1 | 7 | 3.9 | CCCCc1nc2ccccc2n1Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL306670 | 102987 | 0 | None | - | 0 | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 7 | 1 | 7 | 3.9 | CCCCc1nc2ccccc2n1Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44459707 | 93357 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2cc(C3=NNC(=O)CC3C)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL24550 | 93357 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2cc(C3=NNC(=O)CC3C)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 127028618 | 137277 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 4.9 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752198 | 137277 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 4.9 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127034903 | 136438 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735641 | 136438 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 24827902 | 157733 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2ccc(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL408227 | 157733 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2ccc(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 76325126 | 105245 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.1 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115241 | 105245 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.1 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 71653152 | 89152 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337682 | 89152 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365924 | 89152 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 76311800 | 84958 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 538 | 11 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237590 | 84958 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 538 | 11 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956784 | 106557 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314179 | 106557 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956764 | 206077 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85541 | 206077 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 11316515 | 206192 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 5 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86437 | 206192 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 5 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 9889557 | 97053 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 7 | 3 | 7 | 2.7 | CCCCc1nc2c(=O)[nH][nH]c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL267056 | 97053 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 7 | 3 | 7 | 2.7 | CCCCc1nc2c(=O)[nH][nH]c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10028751 | 164916 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 6.1 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL422333 | 164916 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 6.1 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10010164 | 117397 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339806 | 117397 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 14951070 | 203869 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 13 | 2 | 8 | 3.9 | CCCCc1nn(CCCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL68731 | 203869 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 489 | 13 | 2 | 8 | 3.9 | CCCCc1nn(CCCCCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 9930953 | 102802 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL305350 | 102802 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10393086 | 16517 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123670 | 16517 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 11758470 | 113011 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Br)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331121 | 113011 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Br)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 15780091 | 120996 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL35638 | 120996 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9982960 | 119847 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(-c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348616 | 119847 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(-c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10475047 | 117445 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.7 | CCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL339846 | 117445 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.7 | CCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 10141058 | 203793 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 487 | 14 | 1 | 7 | 5.6 | CCCCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| CHEMBL68275 | 203793 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 487 | 14 | 1 | 7 | 5.6 | CCCCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| 10161446 | 102773 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.7 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL305190 | 102773 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.7 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654758 | 203847 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 3 | 7 | 3.7 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL68597 | 203847 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 3 | 7 | 3.7 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654742 | 204069 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 4.6 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL70074 | 204069 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 4.6 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 19385675 | 51374 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15816 | 51374 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10004159 | 119550 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345894 | 119550 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44291830 | 178671 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 13 | 1 | 3 | 7.1 | CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL46782 | 178671 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 13 | 1 | 3 | 7.1 | CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10004159 | 119550 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345894 | 119550 | 0 | None | - | 0 | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44291830 | 178671 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 13 | 1 | 3 | 7.1 | CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL46782 | 178671 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 462 | 13 | 1 | 3 | 7.1 | CCCCC1=NC(CCCC)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 11741660 | 117145 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2c(N)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL339360 | 117145 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2c(N)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 4823 | 93562 | 91 | None | - | 0 | Bovine | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL24646 | 93562 | 91 | None | - | 0 | Bovine | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 164620345 | 186213 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4873167 | 186213 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 44296955 | 194675 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53226 | 194675 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 14956741 | 107054 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL315615 | 107054 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44341731 | 10198 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 4.4 | CCCCC1=NC2(CCN(C(C)=O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115984 | 10198 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 461 | 7 | 1 | 4 | 4.4 | CCCCC1=NC2(CCN(C(C)=O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19889373 | 206177 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL86346 | 206177 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 1610 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| 3941 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| 3961 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| 590 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| DB00678 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL5271135 | 193671 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 4.6 | Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 24827770 | 95880 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259114 | 95880 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 19422638 | 174216 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 404 | 8 | 1 | 3 | 5.2 | CCCCC1=NC(C)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL45485 | 174216 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 404 | 8 | 1 | 3 | 5.2 | CCCCC1=NC(C)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 1610 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 3941 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 3961 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 590 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 10099830 | 108491 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319955 | 108491 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| 44315349 | 60390 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL17487 | 60390 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 1610 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 3941 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 3961 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 590 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 10140958 | 103009 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 485 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CCC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL306882 | 103009 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 485 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CCC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14956804 | 105999 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL313222 | 105999 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 15287891 | 123691 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OCC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL36218 | 123691 | 0 | None | - | 0 | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OCC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 10007528 | 16293 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(C)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122490 | 16293 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(C)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277595 | 6324 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 621 | 9 | 0 | 10 | 5.4 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CC(=O)c4ccco4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL108190 | 6324 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 621 | 9 | 0 | 10 | 5.4 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CC(=O)c4ccco4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44294996 | 189793 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51622 | 189793 | 0 | None | - | 1 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44293657 | 175657 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 534 | 12 | 3 | 6 | 5.3 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL45814 | 175657 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 534 | 12 | 3 | 6 | 5.3 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44293954 | 187699 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 554 | 12 | 3 | 7 | 5.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49526 | 187699 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 554 | 12 | 3 | 7 | 5.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44296985 | 194403 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 8 | 1 | 8 | 6.9 | CCCCc1nc2ccc([C@H]3C4CCCCCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL52880 | 194403 | 0 | None | - | 0 | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 8 | 1 | 8 | 6.9 | CCCCc1nc2ccc([C@H]3C4CCCCCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 10453972 | 22187 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 5.5 | Cc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL132269 | 22187 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 5.5 | Cc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 14951081 | 203692 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 581 | 14 | 1 | 10 | 4.6 | CCCCc1nn(CC(OCC(=O)OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL67515 | 203692 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 581 | 14 | 1 | 10 | 4.6 | CCCCc1nn(CC(OCC(=O)OCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10366029 | 115211 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2ccc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL334515 | 115211 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2ccc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44381714 | 59121 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169827 | 59121 | 0 | None | - | 0 | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44341801 | 9802 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL113701 | 9802 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44341772 | 110592 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 418 | 7 | 0 | 4 | 5.4 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325502 | 110592 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 418 | 7 | 0 | 4 | 5.4 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1021/jm00074a018 | |||
| 44321129 | 111467 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 8 | 1 | 7 | 5.0 | CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL327614 | 111467 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 457 | 8 | 1 | 7 | 5.0 | CCCCn1nc2n(c1=O)C(c1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2CCC | 10.1016/S0960-894X(01)80290-0 | |||
| 10026315 | 116104 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cccc(NC(C)=O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL335734 | 116104 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cccc(NC(C)=O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 24827899 | 96889 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 411 | 5 | 1 | 7 | 3.4 | CCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265697 | 96889 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 411 | 5 | 1 | 7 | 3.4 | CCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00092a017 | |||
| 44348302 | 16491 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL123562 | 16491 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | |||
| 44438870 | 92005 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241685 | 92005 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44291438 | 183831 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 440 | 8 | 1 | 3 | 5.9 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL48062 | 183831 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 440 | 8 | 1 | 3 | 5.9 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44348302 | 16491 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | |||
| CHEMBL123562 | 16491 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 71521299 | 86824 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 479 | 6 | 1 | 7 | 4.8 | CCc1nc2ccn(CC(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322441 | 86824 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 479 | 6 | 1 | 7 | 4.8 | CCc1nc2ccn(CC(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 127036102 | 136514 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736295 | 136514 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL5075338 | 214368 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CCOC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H](C)NC(=O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||||
| 70686409 | 76326 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058855 | 76326 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 71521196 | 86822 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 8 | 1 | 9 | 4.9 | CCc1nc2ccn(CC(=O)OCc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322439 | 86822 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 8 | 1 | 9 | 4.9 | CCc1nc2ccn(CC(=O)OCc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 10098452 | 51440 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL158209 | 51440 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341651 | 110483 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL324785 | 110483 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10098452 | 51440 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158209 | 51440 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15231798 | 206442 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 452 | 9 | 1 | 5 | 6.4 | CCCCc1nc(CCCC)n2c1C=CCC2c1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL88014 | 206442 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 452 | 9 | 1 | 5 | 6.4 | CCCCc1nc(CCCC)n2c1C=CCC2c1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80290-0 | |||
| 14950502 | 85635 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 6 | 1 | 6 | 3.9 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C=O)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22837 | 85635 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 6 | 1 | 6 | 3.9 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C=O)c(C)n1 | 10.1021/jm00061a016 | |||
| 15654756 | 102399 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.4 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL303955 | 102399 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.4 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654741 | 203984 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 5 | 2 | 6 | 3.9 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69522 | 203984 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 5 | 2 | 6 | 3.9 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 22596780 | 204400 | 1 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 416 | 7 | 2 | 5 | 4.5 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71954 | 204400 | 1 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 416 | 7 | 2 | 5 | 4.5 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a016 | |||
| 10321914 | 120048 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL350446 | 120048 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10321914 | 120048 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL350446 | 120048 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 54768661 | 65118 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 535 | 8 | 1 | 8 | 5.3 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cc(C)cc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824001 | 65118 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 535 | 8 | 1 | 8 | 5.3 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cc(C)cc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| 44293991 | 101680 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 532 | 12 | 1 | 6 | 5.9 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL299324 | 101680 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 532 | 12 | 1 | 6 | 5.9 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| 11757216 | 16620 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 12 | 0 | 8 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c(C)noc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124141 | 16620 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 12 | 0 | 8 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c(C)noc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 57380649 | 70375 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945149 | 70375 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 2121583 | 23376 | 8 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1332729 | 23376 | 8 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| 2121583 | 23376 | 8 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1332729 | 23376 | 8 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| 44274672 | 91554 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 8 | 2 | 7 | 4.7 | CCCCc1nc2ccc(NC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24053 | 91554 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 8 | 2 | 7 | 4.7 | CCCCc1nc2ccc(NC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274824 | 99263 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL281846 | 99263 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956756 | 206371 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87513 | 206371 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| 136401481 | 160838 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 651 | 11 | 1 | 11 | 5.7 | CCc1cc2c(=O)n(C/C(=N\OC(C)C)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL4114737 | 160838 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 651 | 11 | 1 | 11 | 5.7 | CCc1cc2c(=O)n(C/C(=N\OC(C)C)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 44274824 | 99263 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL281846 | 99263 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44311583 | 204120 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70353 | 204120 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10209324 | 14490 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 8 | 1 | 7 | 6.2 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| CHEMBL12013 | 14490 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 8 | 1 | 7 | 6.2 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| 9871837 | 15203 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 10 | 2 | 7 | 4.9 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1039/C4MD00499J | |||
| CHEMBL12106 | 15203 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 10 | 2 | 7 | 4.9 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1039/C4MD00499J | |||
| 15222070 | 102297 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL303426 | 102297 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311662 | 102681 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL304620 | 102681 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | |||
| 15222094 | 102974 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306489 | 102974 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311681 | 103023 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306961 | 103023 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222092 | 103824 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309165 | 103824 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311451 | 104102 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309367 | 104102 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311497 | 167857 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL430997 | 167857 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311663 | 204189 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70796 | 204189 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311499 | 204399 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL71953 | 204399 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| 44311648 | 204527 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72721 | 204527 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311758 | 204671 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL73780 | 204671 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 19742811 | 57421 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL165354 | 57421 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10077555 | 207410 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL93956 | 207410 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | |||
| 10440144 | 116894 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338342 | 116894 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315349 | 60390 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL17487 | 60390 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| 108185 | 1614 | 78 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 586 | 1614 | 78 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| CHEMBL907 | 1614 | 78 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 1037 | 1578 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 3940 | 1578 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 5281037 | 1578 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 588 | 1578 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| DB00876 | 1578 | 69 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 44285372 | 100291 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 4.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL289105 | 100291 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 4.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44338666 | 110958 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL326217 | 110958 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 9850834 | 154662 | 17 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL39959 | 154662 | 17 | None | - | 1 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 14956779 | 68663 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL19202 | 68663 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10031067 | 100352 | 4 | None | - | 3 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| CHEMBL289614 | 100352 | 4 | None | - | 3 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| 127030943 | 139195 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787243 | 139195 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787375 | 139195 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787700 | 139195 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 44277462 | 14772 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL1206522 | 14772 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281890 | 14772 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277548 | 99410 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 12 | 0 | 10 | 4.6 | COCCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282777 | 99410 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 12 | 0 | 10 | 4.6 | COCCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10479475 | 115226 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 462 | 6 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL334670 | 115226 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 462 | 6 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00050a002 | |||
| 44288322 | 155201 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 470 | 7 | 1 | 5 | 5.8 | CCCCC1=NC2(CCCC2)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL40251 | 155201 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 470 | 7 | 1 | 5 | 5.8 | CCCCC1=NC2(CCCC2)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 10393837 | 167944 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL431619 | 167944 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | |||
| 10462573 | 117009 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338889 | 117009 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372550 | 164516 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL421478 | 164516 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315344 | 105081 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311386 | 105081 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 18950607 | 50418 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15729 | 50418 | 0 | None | - | 0 | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 10004646 | 17953 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126037 | 17953 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 136052253 | 124524 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 624 | 10 | 1 | 11 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3OC)c2s1 | nan | |||
| CHEMBL3640160 | 124524 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 624 | 10 | 1 | 11 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3OC)c2s1 | nan | |||
| 44278118 | 96986 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 587 | 9 | 0 | 8 | 5.9 | CCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL266480 | 96986 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 587 | 9 | 0 | 8 | 5.9 | CCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277737 | 100622 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CCOC(=O)CCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29192 | 100622 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CCOC(=O)CCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44315180 | 102896 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305956 | 102896 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315059 | 204712 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74144 | 204712 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315057 | 204829 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL75401 | 204829 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19802473 | 198705 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58156 | 198705 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44305267 | 203401 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL65503 | 203401 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10101582 | 119376 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344466 | 119376 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1007/s00044-013-0831-x | |||
| 9979771 | 17446 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125766 | 17446 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9935106 | 65282 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL18287 | 65282 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44338708 | 110444 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL324629 | 110444 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 44277443 | 100298 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28918 | 100298 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL938 | 215907 | 28 | None | - | 2 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm00074a018 | |||||
| 9935106 | 65282 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL18287 | 65282 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 57380412 | 70528 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947129 | 70528 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 44303230 | 200647 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL59957 | 200647 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10349506 | 208059 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97615 | 208059 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | |||
| 44305681 | 102627 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304251 | 102627 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10101582 | 119376 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | |||
| CHEMBL344466 | 119376 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | |||
| 76333687 | 85259 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 506 | 11 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C2(C(=O)OC)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259779 | 85259 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 506 | 11 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C2(C(=O)OC)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 15231091 | 93988 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL24861 | 93988 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44338697 | 109659 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL322471 | 109659 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 44277738 | 100186 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 7 | 0 | 8 | 6.3 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(C(=O)c4ccccc4)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28816 | 100186 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 7 | 0 | 8 | 6.3 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(C(=O)c4ccccc4)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 76324571 | 103981 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 378 | 7 | 1 | 8 | 1.9 | CCCCc1nn(C)c(=O)n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2013.10.017 | |||
| CHEMBL3092993 | 103981 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 378 | 7 | 1 | 8 | 1.9 | CCCCc1nn(C)c(=O)n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2013.10.017 | |||
| 9939191 | 98946 | 1 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 15231091 | 93988 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL24861 | 93988 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 10095986 | 16493 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123568 | 16493 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277901 | 101392 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 10 | 1 | 9 | 4.7 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCCO)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29722 | 101392 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 10 | 1 | 9 | 4.7 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCCO)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 11764669 | 66820 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL18606 | 66820 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 46910495 | 76332 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058861 | 76332 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 54578725 | 65127 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 403 | 8 | 3 | 7 | 4.0 | CCCCn1ncc(C(=O)O)c1Nc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824184 | 65127 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 403 | 8 | 3 | 7 | 4.0 | CCCCn1ncc(C(=O)O)c1Nc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 44211506 | 57541 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL166338 | 57541 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44376780 | 56504 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163486 | 56504 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10349845 | 11362 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179731 | 11362 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97271 | 11362 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 11764669 | 66820 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL18606 | 66820 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10054753 | 208146 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98140 | 208146 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 135723840 | 139142 | 0 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787059 | 139142 | 0 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 9984303 | 17597 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125818 | 17597 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127035264 | 136506 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736244 | 136506 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 183134 | 204844 | 17 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm200409s | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm200409s | |||
| 2806 | 3969 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 3937 | 3969 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 593 | 3969 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 60846 | 3969 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL1069 | 3969 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| DB00177 | 3969 | 110 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 10342301 | 17938 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125937 | 17938 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277547 | 99203 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 10 | 0 | 9 | 6.2 | CCCCCN(C(=O)c1cccs1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281453 | 99203 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 10 | 0 | 9 | 6.2 | CCCCCN(C(=O)c1cccs1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277463 | 101306 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1ccncc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29654 | 101306 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1ccncc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44348408 | 113573 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL332239 | 113573 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | |||
| 44379086 | 56578 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164174 | 56578 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 108185 | 1614 | 78 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00043a020 | |||
| 586 | 1614 | 78 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00043a020 | |||
| CHEMBL907 | 1614 | 78 | None | - | 1 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00043a020 | |||
| 10372723 | 107318 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317368 | 107318 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10349029 | 208096 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97812 | 208096 | 0 | None | - | 0 | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | |||
| 145946921 | 167600 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337687 | 167600 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337688 | 167600 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL4300967 | 167600 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 10298977 | 206323 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87239 | 206323 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 131654 | 206403 | 12 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87778 | 206403 | 12 | None | - | 1 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10055096 | 98285 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL274712 | 98285 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 25147556 | 173863 | 0 | None | - | 0 | Bovine | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL453934 | 173863 | 0 | None | - | 0 | Bovine | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44377261 | 119918 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 1 | 7 | 3.6 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349389 | 119918 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 1 | 7 | 3.6 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10055096 | 98285 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL274712 | 98285 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 44316916 | 205296 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL79242 | 205296 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 44295009 | 187171 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL49207 | 187171 | 0 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44275060 | 99715 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 7 | 2 | 7 | 6.3 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccccc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL284764 | 99715 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 7 | 2 | 7 | 6.3 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccccc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10370172 | 50828 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157690 | 50828 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44277444 | 100937 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 569 | 11 | 0 | 8 | 6.5 | CCCCCN(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29402 | 100937 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 569 | 11 | 0 | 8 | 6.5 | CCCCCN(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 15356436 | 102014 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 514 | 12 | 3 | 6 | 4.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL301705 | 102014 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 514 | 12 | 3 | 6 | 4.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44311406 | 103807 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309081 | 103807 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44341670 | 9956 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 434 | 9 | 1 | 3 | 6.0 | CCCCC1=NC(C(C)C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114687 | 9956 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 434 | 9 | 1 | 3 | 6.0 | CCCCC1=NC(C(C)C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44322315 | 206258 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 7 | 1 | 7 | 4.7 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL86858 | 206258 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 7 | 1 | 7 | 4.7 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44285177 | 138656 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 496 | 6 | 1 | 5 | 4.9 | CCCC1=NC(C(F)(F)F)(C(F)(F)F)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL37768 | 138656 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 496 | 6 | 1 | 5 | 4.9 | CCCC1=NC(C(F)(F)F)(C(F)(F)F)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10370172 | 50828 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157690 | 50828 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 73349424 | 92631 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435833 | 92631 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 44311568 | 98184 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL273992 | 98184 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311636 | 204129 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70389 | 204129 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311569 | 204704 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL74113 | 204704 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44377086 | 119951 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349652 | 119951 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10202093 | 206435 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87985 | 206435 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44305267 | 203401 | 0 | None | - | 0 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL65503 | 203401 | 0 | None | - | 0 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 19385603 | 98779 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278234 | 98779 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 44294976 | 161667 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | CCOC(=O)/C=C1\CC(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL413098 | 161667 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | CCOC(=O)/C=C1\CC(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 15699056 | 109680 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 | 10.1021/jm00114a021 | |||
| CHEMBL322683 | 109680 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 | 10.1021/jm00114a021 | |||
| 44459821 | 96384 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 5.2 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26179 | 96384 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 5.2 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11930 | 1019 | 0 | None | - | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| 15780052 | 1019 | 0 | None | - | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL289472 | 1019 | 0 | None | - | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44438869 | 146335 | 0 | None | - | 1 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL392118 | 146335 | 0 | None | - | 1 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | |||
| 10600595 | 111148 | 23 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 9 | 2 | 8 | 4.1 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL326400 | 111148 | 23 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 9 | 2 | 8 | 4.1 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44342142 | 9947 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL114653 | 9947 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 10363869 | 20466 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3ccc(-c4nn[nH]n4)c3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL13071 | 20466 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3ccc(-c4nn[nH]n4)c3)cc2)n1 | 10.1021/jm00053a013 | |||
| 54768659 | 65116 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 507 | 8 | 1 | 8 | 4.6 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccccc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1823999 | 65116 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 507 | 8 | 1 | 8 | 4.6 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccccc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 10096495 | 19377 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C(F)(F)F)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL129194 | 19377 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C(F)(F)F)c2n1 | 10.1021/jm00100a007 | |||
| 15699055 | 5131 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2ccc(-c3nn[nH]n3)cc2c1 | 10.1021/jm00114a021 | |||
| CHEMBL105724 | 5131 | 0 | None | - | 0 | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2ccc(-c3nn[nH]n3)cc2c1 | 10.1021/jm00114a021 | |||
| 10810628 | 194690 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL53322 | 194690 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 44309366 | 204100 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 4.4 | CCCCc1nc2ccccc2n1Cc1ccc(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL70239 | 204100 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 4.4 | CCCCc1nc2ccccc2n1Cc1ccc(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 10810628 | 194690 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL53322 | 194690 | 0 | None | - | 0 | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 127035068 | 136373 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735036 | 136373 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 164611280 | 184999 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4854474 | 184999 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 53309272 | 63774 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.3 | CCc1nc2c(C)c(C)c(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801736 | 63774 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.3 | CCc1nc2c(C)c(C)c(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 1315061 | 28244 | 9 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 3.3 | Cc1ccc(CN(c2ccc(C(=O)NCc3ccccn3)cc2)S(C)(=O)=O)cc1 | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1374011 | 28244 | 9 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 3.3 | Cc1ccc(CN(c2ccc(C(=O)NCc3ccccn3)cc2)S(C)(=O)=O)cc1 | 10.1016/j.bmc.2016.07.047 | |||
| 70682147 | 76337 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058866 | 76337 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10029950 | 50641 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157524 | 50641 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956750 | 206085 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85596 | 206085 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277653 | 101408 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 645 | 11 | 0 | 9 | 5.9 | CCCCCN(C(=O)c1ccc([S+](C)[O-])cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29730 | 101408 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 645 | 11 | 0 | 9 | 5.9 | CCCCCN(C(=O)c1ccc([S+](C)[O-])cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 18004820 | 16453 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 9 | 2 | 7 | 4.7 | CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL12333 | 16453 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 9 | 2 | 7 | 4.7 | CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10029950 | 50641 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157524 | 50641 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44377198 | 56521 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163628 | 56521 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10259334 | 208038 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97500 | 208038 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | |||
| 23590371 | 161405 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 553 | 12 | 1 | 10 | 4.2 | CCCCc1nn(CC(=O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL412664 | 161405 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 553 | 12 | 1 | 10 | 4.2 | CCCCc1nn(CC(=O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10076199 | 116655 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 548 | 9 | 3 | 6 | 6.7 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL337025 | 116655 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 548 | 9 | 3 | 6 | 6.7 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 9805344 | 99040 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL280290 | 99040 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 15287886 | 137610 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 8 | 1 | 5 | 6.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2c(Cl)cccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL37566 | 137610 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 8 | 1 | 5 | 6.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2c(Cl)cccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44286911 | 161789 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 5 | 1 | 2 | 6.2 | O=C(O)C(Oc1ccc(Cl)cc1C1CCCCC1)c1ccc(Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41416 | 161789 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 5 | 1 | 2 | 6.2 | O=C(O)C(Oc1ccc(Cl)cc1C1CCCCC1)c1ccc(Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44277462 | 14772 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL1206522 | 14772 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281890 | 14772 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10077513 | 17274 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(Br)cs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125697 | 17274 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(Br)cs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44294989 | 163206 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL418269 | 163206 | 0 | None | - | 0 | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44293466 | 101140 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 604 | 14 | 1 | 8 | 6.0 | CCCCc1nc(Cl)c(CCC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL295311 | 101140 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 604 | 14 | 1 | 8 | 6.0 | CCCCc1nc(Cl)c(CCC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 44293962 | 101388 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 518 | 12 | 2 | 5 | 5.8 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL297202 | 101388 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 518 | 12 | 2 | 5 | 5.8 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| 44293990 | 187327 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 548 | 12 | 2 | 7 | 5.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49306 | 187327 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 548 | 12 | 2 | 7 | 5.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 10073122 | 119788 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL348149 | 119788 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44291654 | 174267 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL45493 | 174267 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10073122 | 119788 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348149 | 119788 | 0 | None | - | 0 | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44291654 | 174267 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL45493 | 174267 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(CC(C)C)(CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44296533 | 194742 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 393 | 8 | 3 | 4 | 4.0 | CCCc1cc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL53631 | 194742 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 393 | 8 | 3 | 4 | 4.0 | CCCc1cc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44304147 | 100776 | 0 | None | - | 0 | Rabbit | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL292939 | 100776 | 0 | None | - | 0 | Rabbit | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 46910583 | 70352 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945008 | 70352 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127036297 | 136427 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735492 | 136427 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 11190917 | 168807 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)c(Cl)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL437659 | 168807 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)c(Cl)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 127035219 | 136358 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734849 | 136358 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 4803452 | 39634 | 6 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 457 | 6 | 1 | 4 | 3.6 | Cc1ccc(C)c(NC(=O)CN(C)C(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)c1 | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1474431 | 39634 | 6 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 457 | 6 | 1 | 4 | 3.6 | Cc1ccc(C)c(NC(=O)CN(C)C(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)c1 | 10.1016/j.bmc.2016.07.047 | |||
| 10275744 | 206118 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85876 | 206118 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15356432 | 186669 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 14 | 3 | 6 | 5.9 | CCCCc1nc(Cl)c(CCC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48824 | 186669 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 14 | 3 | 6 | 5.9 | CCCCc1nc(Cl)c(CCC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44307195 | 102258 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL303186 | 102258 | 0 | None | - | 0 | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44264673 | 204692 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 4.3 | CCCCc1nc2cnnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL7396 | 204692 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 4.3 | CCCCc1nc2cnnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44459662 | 96044 | 0 | None | - | 0 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2ccc(C3=NNC(=O)CC3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL25989 | 96044 | 0 | None | - | 0 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2ccc(C3=NNC(=O)CC3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 108185 | 1614 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm950450f | |||
| 586 | 1614 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm950450f | |||
| CHEMBL907 | 1614 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm950450f | |||
| 10027836 | 18949 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128644 | 18949 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1021/jm00100a007 | |||
| 44309264 | 102677 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 555 | 12 | 2 | 10 | 4.0 | CCCCc1nn(CC(O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL304600 | 102677 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 555 | 12 | 2 | 10 | 4.0 | CCCCc1nn(CC(O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10222835 | 206145 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL86084 | 206145 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 108185 | 1614 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 586 | 1614 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL907 | 1614 | 78 | None | - | 1 | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL5271903 | 193702 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 4.4 | CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5273768 | 193776 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 5.0 | O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 46910494 | 76333 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058862 | 76333 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 44341489 | 9300 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 575 | 12 | 4 | 6 | 2.7 | CCCCC1=NC2(CCN(C(=O)C(N)CCCN=C(N)N)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL110974 | 9300 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 575 | 12 | 4 | 6 | 2.7 | CCCCC1=NC2(CCN(C(=O)C(N)CCCN=C(N)N)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10096463 | 48882 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2c(-c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155954 | 48882 | 0 | None | - | 0 | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2c(-c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10435012 | 117010 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(OC)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL338900 | 117010 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(OC)cc2n1 | 10.1021/jm00100a007 | |||
| 44309242 | 203465 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 339 | 6 | 1 | 5 | 4.3 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL65955 | 203465 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 339 | 6 | 1 | 5 | 4.3 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44308785 | 204078 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 420 | 5 | 1 | 3 | 5.0 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL70134 | 204078 | 0 | None | - | 0 | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 420 | 5 | 1 | 3 | 5.0 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 14956797 | 206419 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87885 | 206419 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 76321525 | 105247 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 552 | 9 | 1 | 7 | 7.2 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115243 | 105247 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 552 | 9 | 1 | 7 | 7.2 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44278151 | 99113 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 619 | 11 | 0 | 9 | 5.4 | CCCCS(=O)(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280875 | 99113 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 619 | 11 | 0 | 9 | 5.4 | CCCCS(=O)(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 9824568 | 204413 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL72053 | 204413 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| 127035716 | 136434 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735588 | 136434 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44211673 | 59720 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL172376 | 59720 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 14950503 | 99552 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| CHEMBL283579 | 99552 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| 44305410 | 162359 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL416507 | 162359 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 73346386 | 92616 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2435818 | 92616 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10460186 | 116859 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 548 | 12 | 0 | 7 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2sccc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL338123 | 116859 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 548 | 12 | 0 | 7 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2sccc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70694919 | 76637 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063983 | 76637 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 130762 | 98247 | 9 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL274447 | 98247 | 9 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44291524 | 184276 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(C)(CC(C)CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL48392 | 184276 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 462 | 11 | 1 | 3 | 6.8 | CCCCC1=NC(C)(CC(C)CC(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 24827769 | 95881 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.7 | CC(C)Cn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259116 | 95881 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.7 | CC(C)Cn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 54771778 | 65121 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 479 | 8 | 2 | 8 | 5.0 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1Nc1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824004 | 65121 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 479 | 8 | 2 | 8 | 5.0 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1Nc1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| 14956757 | 67593 | 0 | None | - | 1 | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL19018 | 67593 | 0 | None | - | 1 | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 15287889 | 100437 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 9 | 2 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL290465 | 100437 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 9 | 2 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 19008935 | 161857 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 463 | 6 | 1 | 6 | 5.8 | CCCCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL414836 | 161857 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 463 | 6 | 1 | 6 | 5.8 | CCCCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| 19010059 | 84966 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237598 | 84966 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 73349223 | 92190 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1ccc(C)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL2425138 | 92190 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1ccc(C)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 44293696 | 101651 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 13 | 3 | 7 | 5.5 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL299130 | 101651 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 13 | 3 | 7 | 5.5 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341794 | 9884 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 8 | 1 | 3 | 5.7 | CCCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114267 | 9884 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 418 | 8 | 1 | 3 | 5.7 | CCCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 53320976 | 57609 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 4.8 | CCc1cc(Oc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2ncccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668124 | 57609 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 4.8 | CCc1cc(Oc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2ncccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| 10280531 | 162931 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 5.1 | CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL417429 | 162931 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 5.1 | CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 70694919 | 76637 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063983 | 76637 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 10436877 | 47995 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155008 | 47995 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9914502 | 119705 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347392 | 119705 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10327728 | 98122 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL273542 | 98122 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44300734 | 101806 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL300154 | 101806 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9982171 | 20505 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 470 | 8 | 2 | 4 | 5.9 | CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130741 | 20505 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 470 | 8 | 2 | 4 | 5.9 | CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 11765394 | 118777 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | |||
| CHEMBL341986 | 118777 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | |||
| 44341946 | 9593 | 13 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL112523 | 9593 | 13 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL5282200 | 194149 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 345 | 4 | 2 | 5 | 2.4 | Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 71521195 | 86821 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 508 | 6 | 1 | 8 | 3.2 | CCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322438 | 86821 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 508 | 6 | 1 | 8 | 3.2 | CCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44293939 | 101199 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 590 | 14 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL295737 | 101199 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 590 | 14 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(C(=O)OCC)c2)cc1 | 10.1021/jm00064a007 | |||
| 10414026 | 157511 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 511 | 7 | 1 | 7 | 6.7 | CCCc1nc2ccc(-c3nc4ccccc4o3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL407978 | 157511 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 511 | 7 | 1 | 7 | 6.7 | CCCc1nc2ccc(-c3nc4ccccc4o3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 44298772 | 195574 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 452 | 8 | 1 | 7 | 4.3 | CCCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL55507 | 195574 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 452 | 8 | 1 | 7 | 4.3 | CCCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44295568 | 101600 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298741 | 101600 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10255042 | 116817 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 490 | 10 | 1 | 4 | 7.3 | CCCCc1ncc(/C=C(/C(=O)O)C(c2ccccc2)c2cccs2)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL337928 | 116817 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 490 | 10 | 1 | 4 | 7.3 | CCCCc1ncc(/C=C(/C(=O)O)C(c2ccccc2)c2cccs2)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 44305823 | 162917 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 400 | 5 | 1 | 7 | 2.3 | Cn1c(=O)cc(C2CC2)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL417410 | 162917 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 400 | 5 | 1 | 7 | 2.3 | Cn1c(=O)cc(C2CC2)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 44295568 | 101600 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298741 | 101600 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10459724 | 17976 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 532 | 12 | 1 | 7 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]c(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126170 | 17976 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 532 | 12 | 1 | 7 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]c(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70688681 | 76639 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063985 | 76639 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 70688681 | 76639 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063985 | 76639 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 44306706 | 203089 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 654 | 10 | 1 | 6 | 7.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL63879 | 203089 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 654 | 10 | 1 | 6 | 7.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44379185 | 57554 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL166428 | 57554 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 14950506 | 85794 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 6 | 1 | 6 | 5.2 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccncc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22945 | 85794 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 6 | 1 | 6 | 5.2 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccncc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 15171385 | 166949 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCCC2 | 10.1021/jm00061a016 | |||
| CHEMBL428711 | 166949 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCCC2 | 10.1021/jm00061a016 | |||
| 14951063 | 102139 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 551 | 10 | 1 | 8 | 5.1 | CCCCc1nn(CC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL302478 | 102139 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 551 | 10 | 1 | 8 | 5.1 | CCCCc1nn(CC(=O)C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44305400 | 202946 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 478 | 8 | 1 | 7 | 3.9 | CCCc1cc(=O)n(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62936 | 202946 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 478 | 8 | 1 | 7 | 3.9 | CCCc1cc(=O)n(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 76315849 | 85411 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 13 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2csc(Br)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2263542 | 85411 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 13 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2csc(Br)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL5277518 | 193936 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 5 | 2.9 | CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 9912059 | 185356 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL48602 | 185356 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44306709 | 102689 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 547 | 6 | 1 | 5 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL304655 | 102689 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 547 | 6 | 1 | 5 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44341585 | 9907 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 522 | 9 | 3 | 6 | 3.6 | CCCCC1=NC2(CCN(C(=O)C(N)CS)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114368 | 9907 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 522 | 9 | 3 | 6 | 3.6 | CCCCC1=NC2(CCN(C(=O)C(N)CS)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44298759 | 189872 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 3.9 | CCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL51689 | 189872 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 3.9 | CCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 19976317 | 206389 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccncc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL87655 | 206389 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccncc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 9912059 | 185356 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL48602 | 185356 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44348378 | 164213 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL421094 | 164213 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| 71521507 | 86808 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccncc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322173 | 86808 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccncc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 19889599 | 101842 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300451 | 101842 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44438902 | 169396 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL442251 | 169396 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 15654748 | 203926 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 3.8 | COCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69144 | 203926 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 3.8 | COCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 9912059 | 185356 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL48602 | 185356 | 0 | None | - | 1 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 19889599 | 101842 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300451 | 101842 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44294181 | 187236 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 607 | 14 | 2 | 8 | 6.2 | CCCCc1nc(-n2cccc2)c(C(=O)OCC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49257 | 187236 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 607 | 14 | 2 | 8 | 6.2 | CCCCc1nc(-n2cccc2)c(C(=O)OCC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341785 | 10147 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115771 | 10147 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/jm00074a018 | |||
| 44309021 | 203978 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 436 | 5 | 1 | 3 | 5.7 | CCCCc1nc2ccccc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL69475 | 203978 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 436 | 5 | 1 | 3 | 5.7 | CCCCc1nc2ccccc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44303857 | 100810 | 0 | None | - | 0 | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293195 | 100810 | 0 | None | - | 0 | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | |||
| 24829094 | 159072 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 4.7 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| CHEMBL409722 | 159072 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 4.7 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| 15144943 | 18047 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 476 | 9 | 1 | 3 | 6.9 | CCCCc1ncc(/C=C(\Cc2ccc(Cl)c(Cl)c2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL126521 | 18047 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 476 | 9 | 1 | 3 | 6.9 | CCCCc1ncc(/C=C(\Cc2ccc(Cl)c(Cl)c2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 2121575 | 59541 | 6 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 381 | 7 | 1 | 4 | 3.5 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(F)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1716544 | 59541 | 6 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 381 | 7 | 1 | 4 | 3.5 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(F)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| 24828706 | 158485 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 3.9 | CCCCn1c(=O)c2ccc(OC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL409095 | 158485 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 3.9 | CCCCn1c(=O)c2ccc(OC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44274707 | 94364 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25075 | 94364 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10482257 | 50738 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157620 | 50738 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44274707 | 94364 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL25075 | 94364 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00114a021 | |||
| 11527144 | 179105 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL297425 | 179105 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL47177 | 179105 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| 10482257 | 50738 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157620 | 50738 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10028993 | 116827 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 6.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC(C)C)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337955 | 116827 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 6.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC(C)C)ccc2n1 | 10.1021/jm00100a007 | |||
| 9984807 | 118457 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCC(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL341210 | 118457 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCC(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| 131590 | 20703 | 44 | None | - | 3 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130896 | 20703 | 44 | None | - | 3 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 9984731 | 21376 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 538 | 9 | 2 | 4 | 7.3 | CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131433 | 21376 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 538 | 9 | 2 | 4 | 7.3 | CCCCc1nc2ccc(N(C)C(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 127029203 | 137427 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753458 | 137427 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44315057 | 204829 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL75401 | 204829 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10076109 | 112855 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 545 | 12 | 0 | 7 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc[n+]2[O-])n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL330942 | 112855 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 545 | 12 | 0 | 7 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc[n+]2[O-])n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44341453 | 9684 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 8 | 1 | 3 | 7.1 | CCCCC1=NC2(CCC(c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL113039 | 9684 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 8 | 1 | 3 | 7.1 | CCCCC1=NC2(CCC(c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44342048 | 110622 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 376 | 7 | 1 | 3 | 4.5 | CCCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325684 | 110622 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 376 | 7 | 1 | 3 | 4.5 | CCCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 135987615 | 100589 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 6 | 3 | 8 | 4.2 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL291689 | 100589 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 6 | 3 | 8 | 4.2 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 9933755 | 55046 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL16165 | 55046 | 0 | None | - | 0 | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 44293439 | 101649 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 493 | 11 | 2 | 8 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(Cc2ccccc2)n2cnnn2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL299105 | 101649 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 493 | 11 | 2 | 8 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(Cc2ccccc2)n2cnnn2)cc1 | 10.1021/jm00064a007 | |||
| 15356440 | 162668 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 450 | 10 | 2 | 5 | 4.7 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(C#N)Cc2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL417009 | 162668 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 450 | 10 | 2 | 5 | 4.7 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)C(C#N)Cc2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| 19792151 | 101815 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300239 | 101815 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 9978845 | 130712 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 408 | 9 | 1 | 3 | 5.6 | CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL36846 | 130712 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 408 | 9 | 1 | 3 | 5.6 | CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 11167226 | 106929 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 5.7 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(O)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL314807 | 106929 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 5.7 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(O)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 3846 | 96825 | 4 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 7 | 2 | 7 | 4.3 | CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26514 | 96825 | 4 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 7 | 2 | 7 | 4.3 | CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956749 | 206218 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86613 | 206218 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15356431 | 101452 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 562 | 13 | 3 | 6 | 5.5 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL297653 | 101452 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 562 | 13 | 3 | 6 | 5.5 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341796 | 163412 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 4.9 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL419583 | 163412 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 390 | 6 | 1 | 3 | 4.9 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44322239 | 206721 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 455 | 7 | 2 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL89846 | 206721 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 455 | 7 | 2 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 11527144 | 179105 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL297425 | 179105 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL47177 | 179105 | 0 | None | - | 1 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44305681 | 102627 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304251 | 102627 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL5289070 | 194456 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 269 | 3 | 2 | 5 | 0.6 | CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 9800025 | 18511 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 380 | 10 | 1 | 5 | 4.5 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3C(=O)O)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12737 | 18511 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 380 | 10 | 1 | 5 | 4.5 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3C(=O)O)cc2)n1 | 10.1021/jm00053a013 | |||
| 10739982 | 10082 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 8 | 2 | 4 | 5.0 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| CHEMBL115393 | 10082 | 0 | None | - | 0 | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 8 | 2 | 4 | 5.0 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| 10410297 | 165312 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.2 | Cc1cc(CCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL423370 | 165312 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.2 | Cc1cc(CCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 44341923 | 110325 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 421 | 10 | 2 | 5 | 4.1 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](CO)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL323911 | 110325 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 421 | 10 | 2 | 5 | 4.1 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](CO)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 10523819 | 193419 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL52601 | 193419 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10523819 | 193419 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL52601 | 193419 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44274741 | 93257 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24488 | 93257 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 76311804 | 84978 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 507 | 11 | 3 | 8 | 4.7 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237610 | 84978 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 507 | 11 | 3 | 8 | 4.7 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44274741 | 93257 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24488 | 93257 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 127035070 | 136472 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 647 | 11 | 2 | 7 | 7.3 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735931 | 136472 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 647 | 11 | 2 | 7 | 7.3 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10370801 | 48429 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155554 | 48429 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10077702 | 50928 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 10 | 2 | 7 | 5.1 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157779 | 50928 | 0 | None | - | 0 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 10 | 2 | 7 | 5.1 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 70686381 | 76214 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 486 | 7 | 1 | 6 | 5.7 | CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058368 | 76214 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 486 | 7 | 1 | 6 | 5.7 | CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 10573495 | 9804 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 4.0 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL113714 | 9804 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 4.0 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10764699 | 114419 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 4.2 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL333155 | 114419 | 0 | None | - | 0 | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 4.2 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10078475 | 113330 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331632 | 113330 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 2541 | 786 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 587 | 786 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 6907 | 786 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL1016 | 786 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| DB00796 | 786 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| DB13919 | 786 | 120 | None | 1 | 6 | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 127034038 | 139197 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3785563 | 139197 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787702 | 139197 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL5275739 | 193870 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.2 | CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 14951086 | 169477 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 585 | 13 | 1 | 8 | 6.2 | CCCCc1nn(CC(OCc2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL443005 | 169477 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 585 | 13 | 1 | 8 | 6.2 | CCCCc1nn(CC(OCc2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14956803 | 206285 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL86986 | 206285 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 15699076 | 5081 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 390 | 7 | 2 | 4 | 4.0 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| CHEMBL105486 | 5081 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 390 | 7 | 2 | 4 | 4.0 | CCCCc1nc(CO)c(Cl)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| 44323112 | 111643 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL328552 | 111643 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 | 10.1021/jm00092a017 | |||
| 19792154 | 189807 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51634 | 189807 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792154 | 189807 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51634 | 189807 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792151 | 101815 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300239 | 101815 | 0 | None | - | 0 | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 46232959 | 200926 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL601678 | 200926 | 1 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44274700 | 165242 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL422932 | 165242 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274700 | 165242 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL422932 | 165242 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11442998 | 206191 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 479 | 6 | 1 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N(C)C)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86436 | 206191 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 479 | 6 | 1 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N(C)C)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 15171421 | 206216 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3c(C)cccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL86604 | 206216 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3c(C)cccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 22407453 | 49758 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15671 | 49758 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL5287876 | 194399 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 295 | 5 | 1 | 4 | 2.5 | CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2023.129349 | |||
| 71521418 | 86830 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 597 | 7 | 1 | 8 | 6.1 | CCc1nc2ccn(Cc3ccccc3OC(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322447 | 86830 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 597 | 7 | 1 | 8 | 6.1 | CCc1nc2ccn(Cc3ccccc3OC(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76333686 | 85257 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 583 | 14 | 1 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259777 | 85257 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 583 | 14 | 1 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9980304 | 98536 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 433 | 9 | 3 | 8 | 1.4 | CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 | 10.1021/jm00053a013 | |||
| CHEMBL276381 | 98536 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 433 | 9 | 3 | 8 | 1.4 | CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 | 10.1021/jm00053a013 | |||
| 25147556 | 173863 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL453934 | 173863 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 23590374 | 203458 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 491 | 10 | 1 | 7 | 5.0 | CCCCc1nn(C/C=C/c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL65905 | 203458 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 491 | 10 | 1 | 7 | 5.0 | CCCCc1nn(C/C=C/c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 24827900 | 96865 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.8 | CCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265452 | 96865 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.8 | CCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 71623945 | 136464 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735839 | 136464 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10052533 | 116702 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2c(NC(=O)NC3CCCCC3)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL337269 | 116702 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2c(NC(=O)NC3CCCCC3)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44316861 | 205185 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 345 | 10 | 3 | 5 | 2.1 | CCCCc1ncc(CNCC(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL78345 | 205185 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 345 | 10 | 3 | 5 | 2.1 | CCCCc1ncc(CNCC(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 44274716 | 96868 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26548 | 96868 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 11756787 | 119499 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345459 | 119499 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10053110 | 85260 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259780 | 85260 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10005890 | 114456 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 492 | 9 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333411 | 114456 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 492 | 9 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10460419 | 100333 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 10 | 2 | 8 | 5.2 | CCCCc1nc2ccn(Cc3ccccc3C(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL289448 | 100333 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 10 | 2 | 8 | 5.2 | CCCCc1nc2ccn(Cc3ccccc3C(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 10005512 | 166165 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 483 | 9 | 2 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL42631 | 166165 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 483 | 9 | 2 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)O)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 44311775 | 103014 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306923 | 103014 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311776 | 103015 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306924 | 103015 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311755 | 103134 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307866 | 103134 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311436 | 204188 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70793 | 204188 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 10408794 | 76638 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063984 | 76638 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 44285178 | 100411 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.6 | CCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL290180 | 100411 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.6 | CCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 11502835 | 100450 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 6 | 1 | 5 | 4.8 | CCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL290614 | 100450 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 6 | 1 | 5 | 4.8 | CCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44210864 | 148105 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39352 | 148105 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 11756787 | 119499 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345459 | 119499 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 73346386 | 92616 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435818 | 92616 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 44311739 | 102607 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL304137 | 102607 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| 44311498 | 102930 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306216 | 102930 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379182 | 58122 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167662 | 58122 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10233073 | 207633 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95198 | 207633 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| 2583 | 3776 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| 592 | 3776 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| 65999 | 3776 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm00077a007 | |||
| 10370090 | 19707 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.2 | CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130095 | 19707 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.2 | CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10051708 | 20720 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 500 | 7 | 1 | 5 | 7.0 | CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130910 | 20720 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 500 | 7 | 1 | 5 | 7.0 | CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10052528 | 165736 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 524 | 7 | 1 | 7 | 6.5 | CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL424629 | 165736 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 524 | 7 | 1 | 7 | 6.5 | CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10140613 | 106096 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL313371 | 106096 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 14956761 | 105971 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL313025 | 105971 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956778 | 206293 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87057 | 206293 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277936 | 101309 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 10 | 0 | 9 | 5.7 | CCCCCN(C(=O)c1ccco1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29658 | 101309 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 10 | 0 | 9 | 5.7 | CCCCCN(C(=O)c1ccco1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 9806554 | 165468 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccn(Cc3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL42397 | 165468 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccn(Cc3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 10053126 | 119512 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345570 | 119512 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76330043 | 85258 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 11 | 2 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259778 | 85258 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 11 | 2 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10007312 | 113285 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CC2CCCCC2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331519 | 113285 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CC2CCCCC2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10482937 | 167137 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL321086 | 167137 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL429058 | 167137 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10053126 | 119512 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345570 | 119512 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19422633 | 179622 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 432 | 8 | 1 | 3 | 5.9 | CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47428 | 179622 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 432 | 8 | 1 | 3 | 5.9 | CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44309700 | 103185 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL308237 | 103185 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10078452 | 107278 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317061 | 107278 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | |||
| 10482937 | 167137 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321086 | 167137 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL429058 | 167137 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10439275 | 168060 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL432392 | 168060 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | |||
| 11765177 | 117008 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338888 | 117008 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44305634 | 102375 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL303822 | 102375 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 15231091 | 93988 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24861 | 93988 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10027175 | 15538 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121874 | 15538 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10075811 | 113283 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331511 | 113283 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277439 | 100452 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29063 | 100452 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 2806 | 3969 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 3937 | 3969 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 593 | 3969 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 60846 | 3969 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| CHEMBL1069 | 3969 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| DB00177 | 3969 | 110 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 10417321 | 15618 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122157 | 15618 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44305446 | 100751 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292781 | 100751 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 15229605 | 48154 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15517 | 48154 | 0 | None | - | 0 | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10408794 | 76638 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063984 | 76638 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 10343090 | 15534 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 10 | 1 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121854 | 15534 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 10 | 1 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127035246 | 136396 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735290 | 136396 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 53309404 | 63779 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 491 | 6 | 1 | 6 | 6.4 | Cc1cc(CC(C)C)nc2c1nc(C(C)C)n2[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801741 | 63779 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 491 | 6 | 1 | 6 | 6.4 | Cc1cc(CC(C)C)nc2c1nc(C(C)C)n2[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 9853391 | 116839 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338027 | 116839 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 14956753 | 107070 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL315776 | 107070 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10141821 | 100058 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL287116 | 100058 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 44379270 | 56857 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164395 | 56857 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 23590373 | 102637 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 8 | 4.0 | CCCCc1nn(CC(O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL304329 | 102637 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 8 | 4.0 | CCCCc1nn(CC(O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10078475 | 113330 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331632 | 113330 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 46910493 | 76335 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058864 | 76335 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10078475 | 113330 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331632 | 113330 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10078475 | 113330 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331632 | 113330 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 4673492 | 4138 | 9 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2010.10.043 | |||
| 8324 | 4138 | 9 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL159096 | 4138 | 9 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2010.10.043 | |||
| 19008869 | 206414 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL87842 | 206414 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 10349791 | 111579 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328176 | 111579 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | |||
| 44315060 | 103057 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307290 | 103057 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44338833 | 9179 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL110265 | 9179 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44277593 | 99411 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282778 | 99411 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 127029202 | 137328 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 598 | 11 | 3 | 7 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752680 | 137328 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 598 | 11 | 3 | 7 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 73357016 | 92623 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435825 | 92623 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 19939495 | 207825 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96314 | 207825 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10461595 | 208120 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97964 | 208120 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | |||
| 44211677 | 130614 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL368149 | 130614 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| 11757471 | 51057 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157878 | 51057 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10414778 | 165284 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL423233 | 165284 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44311609 | 102808 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305369 | 102808 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311638 | 102925 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306186 | 102925 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 132562 | 99683 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL284536 | 99683 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| 10166561 | 10064 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 562 | 9 | 2 | 8 | 5.4 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| CHEMBL11528 | 10064 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 562 | 9 | 2 | 8 | 5.4 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| 10475382 | 76633 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063979 | 76633 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 11757471 | 51057 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157878 | 51057 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10100625 | 51496 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2cc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158257 | 51496 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2cc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10414778 | 165284 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL423233 | 165284 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44275076 | 93815 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 546 | 8 | 1 | 6 | 7.0 | CCCCc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24764 | 93815 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 546 | 8 | 1 | 6 | 7.0 | CCCCc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10765381 | 9573 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL112414 | 9573 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 9896877 | 60232 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL174080 | 60232 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| 14950497 | 85747 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 4.3 | CC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| CHEMBL22908 | 85747 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 4.3 | CC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| 44308901 | 103115 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 555 | 13 | 4 | 10 | 3.2 | CCCCc1nn(CC(OCC(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2C2=NNNN2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL307752 | 103115 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 555 | 13 | 4 | 10 | 3.2 | CCCCc1nn(CC(OCC(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2C2=NNNN2)cc1 | 10.1021/jm00067a015 | |||
| 21840324 | 10149 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 4.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(Cc1ccc(F)cc1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL115783 | 10149 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 4.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(Cc1ccc(F)cc1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 44270306 | 52177 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15882 | 52177 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10475382 | 76633 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063979 | 76633 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 57380415 | 70350 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 577 | 11 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945006 | 70350 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 577 | 11 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127026336 | 137274 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752160 | 137274 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 57380416 | 70351 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945007 | 70351 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 10029332 | 46893 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154083 | 46893 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 130762 | 98247 | 9 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL274447 | 98247 | 9 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 44285371 | 140697 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 512 | 8 | 1 | 5 | 6.0 | CCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL38161 | 140697 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 512 | 8 | 1 | 5 | 6.0 | CCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10029332 | 46893 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154083 | 46893 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10343457 | 18133 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 444 | 10 | 1 | 5 | 5.7 | CCCCc1ncc(/C=C(\Cc2cc(OC)cs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL126921 | 18133 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 444 | 10 | 1 | 5 | 5.7 | CCCCc1ncc(/C=C(\Cc2cc(OC)cs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 14950495 | 99293 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 357 | 5 | 1 | 5 | 4.1 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL281999 | 99293 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 357 | 5 | 1 | 5 | 4.1 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)n1 | 10.1021/jm00061a016 | |||
| 15654751 | 203935 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.9 | CCSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69236 | 203935 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.9 | CCSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 5284633 | 10116 | 63 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C(=O)O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL115622 | 10116 | 63 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C(=O)O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 19422652 | 110494 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 502 | 9 | 1 | 3 | 6.9 | CCCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL324888 | 110494 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 502 | 9 | 1 | 3 | 6.9 | CCCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 15144944 | 168032 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 423 | 9 | 2 | 4 | 5.2 | CCCCc1ncc(/C=C(\Cc2ccc(N)cc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL432222 | 168032 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 423 | 9 | 2 | 4 | 5.2 | CCCCc1ncc(/C=C(\Cc2ccc(N)cc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 11764788 | 100858 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL293501 | 100858 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10459992 | 114266 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 13 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333058 | 114266 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 13 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127034901 | 136478 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 670 | 12 | 2 | 9 | 5.5 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736037 | 136478 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 670 | 12 | 2 | 9 | 5.5 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10029368 | 119845 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348606 | 119845 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 6918269 | 98470 | 11 | None | - | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL275875 | 98470 | 11 | None | - | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL295959 | 98470 | 11 | None | - | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 132562 | 99683 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL284536 | 99683 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 132562 | 99683 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| CHEMBL284536 | 99683 | 6 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| 9869504 | 208047 | 4 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL97533 | 208047 | 4 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| 11764788 | 100858 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL293501 | 100858 | 0 | None | - | 1 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL5283862 | 194231 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 295 | 3 | 2 | 4 | 2.5 | O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 76329880 | 84952 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 9 | 2 | 8 | 3.8 | CCCCc1nnc(SC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237584 | 84952 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 9 | 2 | 8 | 3.8 | CCCCc1nnc(SC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44323091 | 206637 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.2 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL89216 | 206637 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.2 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 | 10.1021/jm00092a017 | |||
| 135464357 | 100558 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 6 | 2 | 7 | 4.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL291502 | 100558 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 6 | 2 | 7 | 4.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 10076683 | 50317 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 405 | 8 | 1 | 7 | 4.2 | CCCCc1nnc(SC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157203 | 50317 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 405 | 8 | 1 | 7 | 4.2 | CCCCc1nnc(SC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9980879 | 116734 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337446 | 116734 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C)c2n1 | 10.1021/jm00100a007 | |||
| 44294703 | 192205 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(C)=O)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL52046 | 192205 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(C)=O)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44348345 | 112844 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 417 | 6 | 1 | 6 | 3.3 | CCOC(=O)/C=C1/C(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL330866 | 112844 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 417 | 6 | 1 | 6 | 3.3 | CCOC(=O)/C=C1/C(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80914-8 | |||
| 19889589 | 185934 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48692 | 185934 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10364310 | 18890 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 411 | 8 | 1 | 3 | 6.5 | CCCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128332 | 18890 | 0 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 411 | 8 | 1 | 3 | 6.5 | CCCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 19889589 | 185934 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48692 | 185934 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 14962909 | 101731 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299597 | 101731 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10346400 | 48910 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155984 | 48910 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44306613 | 203710 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1Oc1ccccc1C(=O)O | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL67616 | 203710 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1Oc1ccccc1C(=O)O | 10.1016/S0960-894X(01)81148-3 | |||
| 3839 | 3757 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| 60919 | 3757 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| 6898 | 3757 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| CHEMBL432162 | 3757 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| DB01349 | 3757 | 84 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| 10346400 | 48910 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155984 | 48910 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44438865 | 93375 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL245644 | 93375 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44297201 | 101992 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 6.2 | CCCCc1nc2ccc([C@@H]3C[C@H]4C5CCC(C)(C)N5O[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301547 | 101992 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 6.2 | CCCCc1nc2ccc([C@@H]3C[C@H]4C5CCC(C)(C)N5O[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44376747 | 120089 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350851 | 120089 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 15654755 | 103808 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 6 | 2 | 7 | 3.6 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL309084 | 103808 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 6 | 2 | 7 | 3.6 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL5276125 | 193884 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 385 | 6 | 1 | 4 | 4.7 | O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 127029201 | 137258 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 644 | 12 | 3 | 9 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3751994 | 137258 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 644 | 12 | 3 | 9 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44294649 | 189089 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51001 | 189089 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 11755164 | 119718 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347513 | 119718 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11756222 | 49368 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCSc1nnc(CCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156396 | 49368 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCSc1nnc(CCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 14962909 | 101731 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299597 | 101731 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10525501 | 101809 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL300186 | 101809 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10525501 | 101809 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL300186 | 101809 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15745369 | 10158 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 460 | 7 | 0 | 4 | 6.6 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115835 | 10158 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 460 | 7 | 0 | 4 | 6.6 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1 | 10.1021/jm00074a018 | |||
| 44322953 | 106551 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL314149 | 106551 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 426 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 | 10.1021/jm00092a017 | |||
| 44308996 | 102973 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 348 | 5 | 1 | 3 | 5.4 | CCCCc1nc2ccccc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL306486 | 102973 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 348 | 5 | 1 | 3 | 5.4 | CCCCc1nc2ccccc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 15654746 | 203713 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 4.8 | CC(C)Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL67636 | 203713 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 4.8 | CC(C)Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15287888 | 100239 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 5.2 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)C2CCCCC2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL288618 | 100239 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 5.2 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)C2CCCCC2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44294207 | 101553 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 440 | 9 | 3 | 6 | 4.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)/C(=N\O)c2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL298364 | 101553 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 440 | 9 | 3 | 6 | 4.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)/C(=N\O)c2ccccc2)cc1 | 10.1021/jm00064a007 | |||
| 44320536 | 206393 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 468 | 5 | 1 | 5 | 4.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2=C3C=CC=CC3N(C)C(=O)C2C(=O)O)cc1 | 10.1021/jm031100t | |||
| CHEMBL87694 | 206393 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 468 | 5 | 1 | 5 | 4.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2=C3C=CC=CC3N(C)C(=O)C2C(=O)O)cc1 | 10.1021/jm031100t | |||
| 57380413 | 70529 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947130 | 70529 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 15355268 | 101682 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299340 | 101682 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44274746 | 99670 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 591 | 7 | 3 | 8 | 5.9 | Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL284455 | 99670 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 591 | 7 | 3 | 8 | 5.9 | Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10408951 | 18845 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12810 | 18845 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 404 | 10 | 1 | 7 | 4.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 14956751 | 206301 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87073 | 206301 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9824290 | 194910 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 5 | 1 | 4 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)ccc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL541212 | 194910 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 5 | 1 | 4 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)ccc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 10483230 | 46830 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154027 | 46830 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44438885 | 90954 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL239378 | 90954 | 0 | None | - | 1 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44315060 | 103057 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307290 | 103057 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10414301 | 22200 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 519 | 11 | 1 | 5 | 6.0 | CCCCc1nc2ccc(N(C)S(=O)(=O)CCC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL132280 | 22200 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 519 | 11 | 1 | 5 | 6.0 | CCCCc1nc2ccc(N(C)S(=O)(=O)CCC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44295069 | 101144 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCC1(CCC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL295369 | 101144 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCC1(CCC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 10028212 | 48918 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155992 | 48918 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44293816 | 185613 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 563 | 11 | 1 | 7 | 6.5 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48640 | 185613 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 563 | 11 | 1 | 7 | 6.5 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 44307174 | 100743 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 4.0 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc([N+](=O)[O-])c1O | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL292739 | 100743 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 4.0 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc([N+](=O)[O-])c1O | 10.1016/S0960-894X(01)81148-3 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 10028212 | 48918 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155992 | 48918 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792124 | 188259 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49980 | 188259 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 10341766 | 117077 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2ccsc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL339233 | 117077 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2ccsc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 19792124 | 188259 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49980 | 188259 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44341650 | 169887 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL444060 | 169887 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44352233 | 18935 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 4.0 | CCCc1cn2nccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL128590 | 18935 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 4.0 | CCCc1cn2nccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 44308795 | 203911 | 0 | None | - | 0 | Bovine | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(I)c(O)c1I | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL69025 | 203911 | 0 | None | - | 0 | Bovine | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(I)c(O)c1I | 10.1016/S0960-894X(01)81149-5 | |||
| 71652856 | 89144 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 11 | 2 | 3 | 6.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337684 | 89144 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 11 | 2 | 3 | 6.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365829 | 89144 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 11 | 2 | 3 | 6.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44210830 | 57483 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL165850 | 57483 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| 14950496 | 85018 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 483 | 5 | 1 | 5 | 4.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22391 | 85018 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 483 | 5 | 1 | 5 | 4.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(C)n1 | 10.1021/jm00061a016 | |||
| 10436618 | 21682 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 517 | 8 | 1 | 5 | 5.7 | CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131839 | 21682 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 517 | 8 | 1 | 5 | 5.7 | CCCCc1nc2ccc(N3CCCCS3(=O)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44305634 | 102375 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL303822 | 102375 | 0 | None | - | 0 | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 11757112 | 112969 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331081 | 112969 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44293818 | 101849 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 579 | 13 | 3 | 7 | 5.7 | CCCCc1nc(-n2cccc2)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL300487 | 101849 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 579 | 13 | 3 | 7 | 5.7 | CCCCc1nc(-n2cccc2)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 15355268 | 101682 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299340 | 101682 | 0 | None | - | 0 | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 14962904 | 193101 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52265 | 193101 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| 14962904 | 193101 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52265 | 193101 | 0 | None | - | 0 | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| 127034919 | 136515 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 2 | 7 | 6.6 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736310 | 136515 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 2 | 7 | 6.6 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 127034739 | 136372 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734989 | 136372 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127026058 | 137246 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 600 | 10 | 3 | 8 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3751899 | 137246 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 600 | 10 | 3 | 8 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 71521298 | 86823 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 6 | 2 | 8 | 3.2 | CCc1nc2ccn(CC(=O)O)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322440 | 86823 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 6 | 2 | 8 | 3.2 | CCc1nc2ccn(CC(=O)O)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76329882 | 84957 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 538 | 12 | 2 | 8 | 5.4 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237589 | 84957 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 538 | 12 | 2 | 8 | 5.4 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19422640 | 100491 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 4.8 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL290988 | 100491 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 4.8 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44377171 | 120211 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL352042 | 120211 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| 10323527 | 48026 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 495 | 11 | 1 | 7 | 5.9 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155035 | 48026 | 0 | None | - | 0 | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 495 | 11 | 1 | 7 | 5.9 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 19422640 | 100491 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 4.8 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL290988 | 100491 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 7 | 1 | 3 | 4.8 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 14951061 | 204346 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 1 | 7 | 5.7 | CCCCc1nn(CCC(C)CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL71613 | 204346 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 1 | 7 | 5.7 | CCCCc1nn(CCC(C)CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00077a007 | |||
| 14952925 | 196822 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 492 | 10 | 2 | 5 | 6.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1cc(Cl)c(C(=O)O)cc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL56574 | 196822 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 492 | 10 | 2 | 5 | 6.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1cc(Cl)c(C(=O)O)cc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| 10098291 | 15558 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 3.6 | CCCCc1ncc(/C=C2/C(=O)N(CO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121990 | 15558 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 3.6 | CCCCc1ncc(/C=C2/C(=O)N(CO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 76322687 | 84950 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 10 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237582 | 84950 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 10 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44342045 | 110376 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 488 | 7 | 1 | 3 | 7.6 | CCCCC1=NC2(CCCCCCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL324245 | 110376 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 488 | 7 | 1 | 3 | 7.6 | CCCCC1=NC2(CCCCCCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10323388 | 49308 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156352 | 49308 | 0 | None | - | 0 | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 130762 | 98247 | 9 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL274447 | 98247 | 9 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44323113 | 206667 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 412 | 8 | 2 | 6 | 4.0 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL89403 | 206667 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 412 | 8 | 2 | 6 | 4.0 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(C2=C(c3nn[nH]n3)CCC2)cc1 | 10.1021/jm00092a017 | |||
| 76322688 | 84954 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 530 | 11 | 2 | 8 | 5.8 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237586 | 84954 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 530 | 11 | 2 | 8 | 5.8 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19010047 | 84969 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 554 | 12 | 3 | 9 | 4.9 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237601 | 84969 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 554 | 12 | 3 | 9 | 4.9 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 15224461 | 19425 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 8 | 2 | 7 | 4.7 | CCCCc1nc2c(C)cnc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL129447 | 19425 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 8 | 2 | 7 | 4.7 | CCCCc1nc2c(C)cnc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 9986992 | 51506 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 511 | 11 | 2 | 8 | 5.3 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158267 | 51506 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 511 | 11 | 2 | 8 | 5.3 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10032191 | 119574 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 10 | 1 | 7 | 6.2 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346145 | 119574 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 10 | 1 | 7 | 6.2 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a015 | |||
| 14951090 | 103210 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 579 | 13 | 1 | 10 | 4.7 | CCCCc1nn(C(CC(=O)OCC)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL308416 | 103210 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 579 | 13 | 1 | 10 | 4.7 | CCCCc1nn(C(CC(=O)OCC)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44287123 | 100191 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 465 | 8 | 1 | 5 | 6.1 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc3ccccc23)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL288222 | 100191 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 465 | 8 | 1 | 5 | 6.1 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc3ccccc23)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 127029204 | 137313 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752530 | 137313 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 71521503 | 86832 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3cccc(C)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322449 | 86832 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3cccc(C)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 135723833 | 198511 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.2 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL57783 | 198511 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.2 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 10811315 | 110276 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 5.1 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL323819 | 110276 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 5.1 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10412363 | 20875 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C#N)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL131050 | 20875 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C#N)ccc2n1 | 10.1021/jm00100a007 | |||
| 121879 | 2234 | 24 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1021/jm0309452 | |||
| 5868 | 2234 | 24 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1021/jm0309452 | |||
| CHEMBL308716 | 2234 | 24 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1021/jm0309452 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00053a013 | |||
| 127028617 | 137568 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 536 | 10 | 3 | 7 | 4.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| CHEMBL3754661 | 137568 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 536 | 10 | 3 | 7 | 4.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| 127034740 | 136491 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736166 | 136491 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035544 | 136360 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734870 | 136360 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 19029576 | 99973 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL286537 | 99973 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 10692816 | 9932 | 1 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 408 | 7 | 3 | 5 | 3.8 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL114527 | 9932 | 1 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 408 | 7 | 3 | 5 | 3.8 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 70688504 | 76336 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058865 | 76336 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 71521301 | 86826 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3ccccc3F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322443 | 86826 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3ccccc3F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76308180 | 84976 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 508 | 11 | 2 | 8 | 4.7 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237608 | 84976 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 508 | 11 | 2 | 8 | 4.7 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44459780 | 92162 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24218 | 92162 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44459634 | 96140 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cccc(C)c2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26048 | 96140 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cccc(C)c2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44294023 | 184578 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 546 | 12 | 2 | 5 | 6.4 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2c(C)ccc2C)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48486 | 184578 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 546 | 12 | 2 | 5 | 6.4 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2c(C)ccc2C)cc1 | 10.1021/jm00064a007 | |||
| 10069271 | 34478 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 395 | 4 | 1 | 5 | 5.5 | Cc1cc(Sc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL142860 | 34478 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 395 | 4 | 1 | 5 | 5.5 | Cc1cc(Sc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| 10389770 | 119643 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 10 | 1 | 7 | 5.1 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346773 | 119643 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 10 | 1 | 7 | 5.1 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10252966 | 32821 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 409 | 5 | 1 | 5 | 5.7 | Cc1cc(SCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL141447 | 32821 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 409 | 5 | 1 | 5 | 5.7 | Cc1cc(SCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 127034918 | 136458 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 599 | 11 | 2 | 7 | 6.6 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| CHEMBL3735797 | 136458 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 599 | 11 | 2 | 7 | 6.6 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| 11527144 | 179105 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL297425 | 179105 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL47177 | 179105 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| 44342047 | 9794 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 390 | 7 | 1 | 3 | 4.9 | CCCCC1=NC2(CCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL113674 | 9794 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 390 | 7 | 1 | 3 | 4.9 | CCCCC1=NC2(CCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 3839 | 3757 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 60919 | 3757 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 6898 | 3757 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL432162 | 3757 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| DB01349 | 3757 | 84 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 9830481 | 194678 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@@H]4ON5[C@@H](CCC5(C)C)[C@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53244 | 194678 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@@H]4ON5[C@@H](CCC5(C)C)[C@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15287892 | 100358 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 5.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL289640 | 100358 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 5.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 127035515 | 136455 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735769 | 136455 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44459856 | 96523 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 6.3 | CCCCc1nc2cc3ccccc3cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26277 | 96523 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 6.3 | CCCCc1nc2cc3ccccc3cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11755164 | 119718 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347513 | 119718 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 127037497 | 136501 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 613 | 9 | 2 | 7 | 6.9 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736225 | 136501 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 613 | 9 | 2 | 7 | 6.9 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 73357018 | 92632 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435834 | 92632 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 24828707 | 95937 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259353 | 95937 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44377111 | 119884 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349020 | 119884 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 8374 | 2922 | 42 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 9937291 | 2922 | 42 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL34124 | 2922 | 42 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| DB16266 | 2922 | 42 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 15654759 | 204101 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 8 | 3 | 7 | 4.5 | CCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL70242 | 204101 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 8 | 3 | 7 | 4.5 | CCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 197647 | 118086 | 6 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 4.3 | CCOc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL340612 | 118086 | 6 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 4.3 | CCOc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 44323090 | 106569 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 6 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL314220 | 106569 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 6 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCCC2)cc1 | 10.1021/jm00092a017 | |||
| 127028620 | 137521 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 5.3 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3754198 | 137521 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 5.3 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 135723837 | 101669 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 458 | 6 | 2 | 8 | 4.9 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL299269 | 101669 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 458 | 6 | 2 | 8 | 4.9 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 10027681 | 18891 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 12 | 2 | 4 | 7.4 | CCCCCNc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1021/jm00077a007 | |||
| CHEMBL128340 | 18891 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 469 | 12 | 2 | 4 | 7.4 | CCCCCNc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1021/jm00077a007 | |||
| 54768876 | 65119 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(C)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824002 | 65119 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(C)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 15654745 | 203921 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 5.1 | CCC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69124 | 203921 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 5.1 | CCC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 22850669 | 202986 | 0 | None | - | 0 | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL63109 | 202986 | 0 | None | - | 0 | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44274734 | 91205 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.2 | CCCCc1nc2ccc(CC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL23994 | 91205 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.2 | CCCCc1nc2ccc(CC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 9955424 | 165124 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL422756 | 165124 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10049809 | 113399 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331859 | 113399 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44274823 | 99075 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL280526 | 99075 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44277677 | 99320 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282168 | 99320 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 9955424 | 165124 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL422756 | 165124 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 19889336 | 179370 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL47382 | 179370 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 18950592 | 16790 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL124541 | 16790 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | |||
| 44285370 | 139245 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 1 | 5 | 3.9 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL37892 | 139245 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 1 | 5 | 3.9 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44209671 | 93602 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24661 | 93602 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19889336 | 179370 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL47382 | 179370 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 44379293 | 120290 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352639 | 120290 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44315350 | 105218 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311484 | 105218 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 204749 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74476 | 204749 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 44372686 | 96655 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | |||
| CHEMBL263714 | 96655 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | |||
| 14950511 | 168405 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 8 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL434768 | 168405 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 8 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 10074895 | 19110 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL128922 | 19110 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10074709 | 19528 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 500 | 7 | 1 | 5 | 7.0 | CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL129950 | 19528 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 500 | 7 | 1 | 5 | 7.0 | CCCc1nc2c(C)cc(-c3cn4ccccc4n3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10053393 | 50019 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156934 | 50019 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956738 | 205798 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL83180 | 205798 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10053393 | 50019 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156934 | 50019 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10026681 | 17939 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125940 | 17939 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10483597 | 163389 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 0 | 9 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL419421 | 163389 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 0 | 9 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44320509 | 206338 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL87327 | 206338 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 9915892 | 103618 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308703 | 103618 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 9915892 | 103618 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL308703 | 103618 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 71652858 | 89154 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337677 | 89154 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365958 | 89154 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44275097 | 99333 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 6.4 | CCCCc1nc2ccc(NC(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL282236 | 99333 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 6.4 | CCCCc1nc2ccc(NC(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 57380414 | 70530 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947131 | 70530 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 19754062 | 102985 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL306641 | 102985 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44377067 | 56563 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL164059 | 56563 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10031920 | 107987 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319404 | 107987 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | |||
| 10078554 | 116968 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338687 | 116968 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44305424 | 102493 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304032 | 102493 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 136093942 | 139094 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3786570 | 139094 | 0 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44277567 | 101397 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29725 | 101397 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44379184 | 57449 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL165541 | 57449 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 14951067 | 203495 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 489 | 12 | 1 | 9 | 3.6 | CCCCc1nn(CCCCC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL66173 | 203495 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 489 | 12 | 1 | 9 | 3.6 | CCCCc1nn(CCCCC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44305680 | 102748 | 0 | None | - | 0 | Bovine | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 561 | 9 | 1 | 9 | 3.2 | CCCc1cc(=O)n(CCN2C(=O)c3ccccc3C2=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL305032 | 102748 | 0 | None | - | 0 | Bovine | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 561 | 9 | 1 | 9 | 3.2 | CCCc1cc(=O)n(CCN2C(=O)c3ccccc3C2=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44277937 | 101414 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1cccnc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29734 | 101414 | 0 | None | - | 0 | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1cccnc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44211708 | 100680 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292316 | 100680 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10183373 | 165010 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL422593 | 165010 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277420 | 101110 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 8 | 0 | 8 | 6.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29512 | 101110 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 8 | 0 | 8 | 6.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9847539 | 182039 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47810 | 182039 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 44309701 | 103186 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL308238 | 103186 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10349897 | 114428 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL333224 | 114428 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10350123 | 57603 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668007 | 57603 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | |||
| 10460346 | 207488 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC#N)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94407 | 207488 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC#N)cc1 | 10.1021/jm00043a020 | |||
| 10007306 | 117184 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339404 | 117184 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10325483 | 16380 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 560 | 12 | 2 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(O)c(O)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122982 | 16380 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 560 | 12 | 2 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(O)c(O)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10478294 | 114110 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332766 | 114110 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956794 | 206078 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85545 | 206078 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44338834 | 7858 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL108981 | 7858 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44277871 | 99700 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28464 | 99700 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277594 | 101803 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30015 | 101803 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9935096 | 207771 | 1 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL9599 | 207771 | 1 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44338834 | 7858 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL108981 | 7858 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 73350991 | 92624 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)c3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435826 | 92624 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)c3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 10670376 | 172047 | 0 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.5 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL447182 | 172047 | 0 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.5 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44294905 | 189149 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51084 | 189149 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 76326259 | 84974 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 598 | 12 | 2 | 10 | 4.2 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237606 | 84974 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 598 | 12 | 2 | 10 | 4.2 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44311429 | 204616 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL73369 | 204616 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10053412 | 51323 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 555 | 11 | 1 | 9 | 4.6 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158115 | 51323 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 555 | 11 | 1 | 9 | 4.6 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 9909335 | 118458 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.5 | Cc1cc(OC(C)c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL341223 | 118458 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.5 | Cc1cc(OC(C)c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 44305446 | 100751 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292781 | 100751 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10369479 | 118493 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 522 | 15 | 0 | 6 | 6.0 | CCCCCCN1C(=O)N(CCCC)C(=O)/C1=C/c1cnc(CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341456 | 118493 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 522 | 15 | 0 | 6 | 6.0 | CCCCCCN1C(=O)N(CCCC)C(=O)/C1=C/c1cnc(CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127035715 | 136440 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735652 | 136440 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 76326258 | 84971 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 9 | 2 | 9 | 2.5 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237603 | 84971 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 9 | 2 | 9 | 2.5 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44323084 | 206503 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 | 10.1021/jm00092a017 | |||
| CHEMBL88350 | 206503 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 440 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(C2=C(c3nn[nH]n3)CCCC2)cc1 | 10.1021/jm00092a017 | |||
| 10094614 | 49262 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 2.9 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156307 | 49262 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 2.9 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 15144940 | 118152 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 453 | 10 | 1 | 5 | 5.5 | CCCCc1ncc(/C=C(\Cc2ccc([N+](=O)[O-])cc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL340825 | 118152 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 453 | 10 | 1 | 5 | 5.5 | CCCCc1ncc(/C=C(\Cc2ccc([N+](=O)[O-])cc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 4110026 | 204935 | 1 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL7632 | 204935 | 1 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44298869 | 101610 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2cc(C)ccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL298836 | 101610 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2cc(C)ccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44298545 | 195929 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 466 | 7 | 1 | 7 | 4.5 | Cc1ccc2nc(OCC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL55939 | 195929 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 466 | 7 | 1 | 7 | 4.5 | Cc1ccc2nc(OCC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| 11167180 | 165423 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 464 | 7 | 1 | 5 | 6.4 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL423861 | 165423 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 464 | 7 | 1 | 5 | 6.4 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 71521300 | 86825 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 7 | 5.7 | CCc1nc2ccn(CC3CCCCC3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322442 | 86825 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 7 | 5.7 | CCc1nc2ccn(CC3CCCCC3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44438872 | 169106 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL440051 | 169106 | 0 | None | - | 1 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10391950 | 115112 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 520 | 12 | 1 | 9 | 3.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2nn[nH]n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL334326 | 115112 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 520 | 12 | 1 | 9 | 3.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2nn[nH]n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44307258 | 203654 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 4 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL67309 | 203654 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 4 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44341787 | 109782 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 5 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C2CCCC2)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL323244 | 109782 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 5 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2C2CCCC2)cc1 | 10.1021/jm00074a018 | |||
| 15780094 | 99810 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL285433 | 99810 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 70684248 | 76278 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058588 | 76278 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 15699053 | 108806 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2cc(-c3nn[nH]n3)ccc12 | 10.1021/jm00114a021 | |||
| CHEMBL320951 | 108806 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2cc(-c3nn[nH]n3)ccc12 | 10.1021/jm00114a021 | |||
| 71717082 | 89149 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337683 | 89149 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365904 | 89149 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 127035069 | 136399 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735300 | 136399 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 9985434 | 50298 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157185 | 50298 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127035379 | 136507 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736248 | 136507 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 135987614 | 100700 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 7 | 3 | 8 | 4.6 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL292430 | 100700 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 7 | 3 | 8 | 4.6 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 44283480 | 100468 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290768 | 100468 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9985434 | 50298 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157185 | 50298 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44297114 | 101801 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN3O4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL300105 | 101801 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN3O4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44297216 | 186821 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL48934 | 186821 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 14956775 | 203981 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL69508 | 203981 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 15287883 | 98210 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL274260 | 98210 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 71654382 | 89145 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 701 | 12 | 3 | 8 | 6.2 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337681 | 89145 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 701 | 12 | 3 | 8 | 6.2 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365830 | 89145 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 701 | 12 | 3 | 8 | 6.2 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 135415867 | 560 | 97 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 6901 | 560 | 97 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL57242 | 560 | 97 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 135487973 | 199148 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 5.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL58938 | 199148 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 5.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 11511750 | 96555 | 1 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL262958 | 96555 | 1 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15698116 | 167736 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 388 | 8 | 2 | 5 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2occc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| CHEMBL430279 | 167736 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 388 | 8 | 2 | 5 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2occc2C(=O)O)cc1 | 10.1021/jm00053a013 | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 24827903 | 95985 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.7 | CCCCn1c(=O)c2cc(F)c(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259575 | 95985 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.7 | CCCCn1c(=O)c2cc(F)c(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 14956743 | 164105 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL420970 | 164105 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44297046 | 168188 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL433278 | 168188 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 14951088 | 203946 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 521 | 10 | 1 | 8 | 4.9 | CCCCc1nn(C(C)(C)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL69296 | 203946 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 521 | 10 | 1 | 8 | 4.9 | CCCCc1nn(C(C)(C)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 130762 | 98247 | 9 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00100a007 | |||
| CHEMBL274447 | 98247 | 9 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00100a007 | |||
| 3082918 | 95069 | 1 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 340 | 7 | 1 | 3 | 4.2 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL25528 | 95069 | 1 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 340 | 7 | 1 | 3 | 4.2 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 127028619 | 137495 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 11 | 3 | 7 | 5.3 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| CHEMBL3754010 | 137495 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 11 | 3 | 7 | 5.3 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| 10478476 | 103046 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| CHEMBL307191 | 103046 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| 44312700 | 204736 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 457 | 6 | 3 | 8 | 2.0 | O=C(O)c1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| CHEMBL74347 | 204736 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 457 | 6 | 3 | 8 | 2.0 | O=C(O)c1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| 44301981 | 100627 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL291944 | 100627 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 10478476 | 103046 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL307191 | 103046 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| 127026043 | 137353 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 607 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752947 | 137353 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 607 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44300827 | 101767 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL299897 | 101767 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44211708 | 100680 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292316 | 100680 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44307087 | 203775 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL68111 | 203775 | 0 | None | - | 0 | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 9843116 | 113503 | 84 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 385 | 6 | 0 | 3 | 5.5 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL332051 | 113503 | 84 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 385 | 6 | 0 | 3 | 5.5 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1021/jm00074a018 | |||
| 19792146 | 101902 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300861 | 101902 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15069407 | 189643 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51508 | 189643 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10047444 | 100347 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL289543 | 100347 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 15654700 | 163756 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 7 | 1 | 8 | 4.8 | CCSc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL420551 | 163756 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 7 | 1 | 8 | 4.8 | CCSc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654749 | 203830 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.2 | CCOCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL68494 | 203830 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.2 | CCOCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 14952903 | 195575 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 380 | 9 | 1 | 4 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL55508 | 195575 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 380 | 9 | 1 | 4 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1 | 10.1016/S0960-894X(01)81116-1 | |||
| 15069407 | 189643 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51508 | 189643 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792146 | 101902 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300861 | 101902 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44298808 | 101982 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 3.5 | CCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL301479 | 101982 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 3.5 | CCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10255888 | 76636 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063982 | 76636 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 10255888 | 76636 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063982 | 76636 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 44210836 | 56509 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL163523 | 56509 | 0 | None | - | 0 | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| 70694736 | 76213 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 472 | 6 | 1 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058367 | 76213 | 0 | None | - | 0 | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 472 | 6 | 1 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| 14951085 | 103187 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 537 | 13 | 1 | 8 | 5.5 | CCCCc1nn(CC(OCCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL308239 | 103187 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 537 | 13 | 1 | 8 | 5.5 | CCCCc1nn(CC(OCCC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 71521506 | 86807 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3cccnc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322172 | 86807 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3cccnc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 19792159 | 193280 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52398 | 193280 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792159 | 193280 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52398 | 193280 | 0 | None | - | 0 | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44296550 | 188800 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 407 | 9 | 2 | 4 | 4.7 | CCCc1cc(COC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL50592 | 188800 | 0 | None | - | 0 | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 407 | 9 | 2 | 4 | 4.7 | CCCc1cc(COC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL86558 | 206209 | 0 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 414 | 8 | 1 | 5 | 4.7 | CCCCN1N=C(CCC)/C(=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O | 10.1016/S0960-894X(01)80290-0 | |||
| 10642524 | 9619 | 1 | None | - | 0 | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL112637 | 9619 | 1 | None | - | 0 | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 44303859 | 200991 | 0 | None | - | 0 | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL60209 | 200991 | 0 | None | - | 0 | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| 15654716 | 103785 | 0 | None | - | 0 | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(C(=O)O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL308911 | 103785 | 0 | None | - | 0 | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(C(=O)O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10047444 | 100347 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL289543 | 100347 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| 9910561 | 10047 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 8 | 2 | 6 | 4.6 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115206 | 10047 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 8 | 2 | 6 | 4.6 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 9867026 | 203928 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 424 | 6 | 2 | 6 | 4.2 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69154 | 203928 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 424 | 6 | 2 | 6 | 4.2 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10004855 | 116725 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C#N)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337380 | 116725 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C#N)cc2n1 | 10.1021/jm00100a007 | |||
| 10094851 | 21297 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131365 | 21297 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 15699075 | 5422 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 390 | 7 | 2 | 4 | 4.0 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| CHEMBL107271 | 5422 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 390 | 7 | 2 | 4 | 4.0 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C)(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| 10621927 | 110862 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL326086 | 110862 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 10094965 | 18923 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1nc2ccccc2c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C | 10.1021/jm00100a007 | |||
| CHEMBL128536 | 18923 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1nc2ccccc2c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C | 10.1021/jm00100a007 | |||
| 24828708 | 159741 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c2nc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410487 | 159741 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c2nc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 127037496 | 136403 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 613 | 12 | 2 | 7 | 6.9 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| CHEMBL3735311 | 136403 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 613 | 12 | 2 | 7 | 6.9 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| 44341792 | 110585 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 420 | 7 | 1 | 4 | 4.5 | CCCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325445 | 110585 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 420 | 7 | 1 | 4 | 4.5 | CCCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 127035067 | 136392 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 683 | 12 | 2 | 9 | 5.4 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735236 | 136392 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 683 | 12 | 2 | 9 | 5.4 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10482340 | 17645 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 537 | 11 | 0 | 9 | 4.2 | CCCCc1ncc(/C=C2/C(=O)N(COC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125835 | 17645 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 537 | 11 | 0 | 9 | 4.2 | CCCCc1ncc(/C=C2/C(=O)N(COC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10325295 | 118178 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 551 | 12 | 1 | 9 | 4.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL340882 | 118178 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 551 | 12 | 1 | 9 | 4.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44295090 | 101654 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL299151 | 101654 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 10343392 | 20154 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1ccc2nc(C)cc(OCc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1021/jm00100a007 | |||
| CHEMBL130455 | 20154 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1ccc2nc(C)cc(OCc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1021/jm00100a007 | |||
| 44309268 | 203865 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 4.8 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL68713 | 203865 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 4.8 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 76329884 | 84972 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 590 | 11 | 2 | 9 | 4.7 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237604 | 84972 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 590 | 11 | 2 | 9 | 4.7 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44210646 | 19106 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1cn2ncc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL128920 | 19106 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1cn2ncc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 10395045 | 119734 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 547 | 10 | 1 | 8 | 5.1 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347630 | 119734 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 547 | 10 | 1 | 8 | 5.1 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44317214 | 104759 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL310752 | 104759 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 10072403 | 17078 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 11 | 1 | 9 | 3.9 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cc([N+](=O)[O-])cc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12548 | 17078 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 11 | 1 | 9 | 3.9 | CCCCc1nc(CCCC)n(Cc2ccc(-n3cc([N+](=O)[O-])cc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 11744700 | 119681 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347234 | 119681 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341608 | 110661 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 567 | 9 | 2 | 5 | 5.4 | CCCCC1=NC2(CCN(C(=O)c3ccccc3C(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325905 | 110661 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 567 | 9 | 2 | 5 | 5.4 | CCCCC1=NC2(CCN(C(=O)c3ccccc3C(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 135723851 | 100823 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 472 | 7 | 2 | 8 | 5.3 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL293308 | 100823 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 472 | 7 | 2 | 8 | 5.3 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 11744700 | 119681 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347234 | 119681 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10408577 | 21814 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131948 | 21814 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 10253216 | 50719 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157597 | 50719 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10253216 | 50719 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157597 | 50719 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 127035392 | 136499 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736202 | 136499 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 11757293 | 119839 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL348568 | 119839 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341756 | 9961 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 523 | 8 | 1 | 4 | 5.7 | CCCCC1=NC2(CCN(C(=O)c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114720 | 9961 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 523 | 8 | 1 | 4 | 5.7 | CCCCC1=NC2(CCN(C(=O)c3ccccc3)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 11757293 | 119839 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348568 | 119839 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 14956799 | 106899 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314590 | 106899 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 130762 | 98247 | 9 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL274447 | 98247 | 9 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 130762 | 98247 | 9 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL274447 | 98247 | 9 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15654730 | 204240 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | COC(=O)c1cccc2nc(OC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| CHEMBL71038 | 204240 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | COC(=O)c1cccc2nc(OC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| 44298546 | 100696 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 4.1 | CCOC(=O)c1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL292412 | 100696 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 4.1 | CCOC(=O)c1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| 11785963 | 205835 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 535 | 10 | 1 | 6 | 7.2 | CCCN(CCC)c1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O | 10.1021/jm031100t | |||
| CHEMBL83452 | 205835 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 535 | 10 | 1 | 6 | 7.2 | CCCN(CCC)c1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O | 10.1021/jm031100t | |||
| 127036105 | 136518 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736336 | 136518 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44209951 | 92180 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24240 | 92180 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44209671 | 93602 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24661 | 93602 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274671 | 94234 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 8 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25000 | 94234 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 8 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956748 | 205973 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL84627 | 205973 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44209951 | 92180 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24240 | 92180 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00064a007 | |||
| 9870463 | 102249 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL303147 | 102249 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 9887844 | 163200 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL418226 | 163200 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 9870463 | 102249 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL303147 | 102249 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/j.bmc.2010.10.043 | |||
| 9887844 | 163200 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL418226 | 163200 | 4 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 131654 | 206403 | 12 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL87778 | 206403 | 12 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80290-0 | |||
| 44275108 | 94749 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 513 | 8 | 1 | 7 | 5.7 | CCCCc1nc2ccc(-c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25313 | 94749 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 513 | 8 | 1 | 7 | 5.7 | CCCCc1nc2ccc(-c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 127035717 | 136416 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735409 | 136416 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10053595 | 103116 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL307756 | 103116 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311738 | 204191 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 10 | 2 | 8 | 4.4 | CCCc1nc(CN2CCN(C(=O)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70801 | 204191 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 10 | 2 | 8 | 4.4 | CCCc1nc(CN2CCN(C(=O)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379334 | 58111 | 1 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167584 | 58111 | 1 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10054912 | 207632 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95197 | 207632 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | |||
| 44373417 | 52383 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | |||
| CHEMBL159004 | 52383 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | |||
| 14950508 | 99571 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL283742 | 99571 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| 15171368 | 168066 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(CC)n1 | 10.1021/jm00061a016 | |||
| CHEMBL432459 | 168066 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(CC)n1 | 10.1021/jm00061a016 | |||
| 10480536 | 21629 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 7 | 1 | 6 | 6.3 | CCCc1nc2c(C)cc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL131767 | 21629 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 7 | 1 | 6 | 6.3 | CCCc1nc2c(C)cc(-c3ccccn3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 10481936 | 116697 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 524 | 7 | 1 | 7 | 6.4 | CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL337232 | 116697 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 524 | 7 | 1 | 7 | 6.4 | CCCc1nc2ccc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 15287890 | 155771 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 8 | 1 | 5 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40585 | 155771 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 8 | 1 | 5 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44277574 | 101901 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30086 | 101901 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 15231094 | 139297 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL37919 | 139297 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 71521302 | 86827 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322444 | 86827 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 131654 | 206403 | 12 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87778 | 206403 | 12 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44348355 | 113387 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL331797 | 113387 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | |||
| 53309406 | 63781 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 511 | 6 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(Cc3ccccc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801743 | 63781 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 511 | 6 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(Cc3ccccc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 9847539 | 182039 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47810 | 182039 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=NC(C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 10349256 | 111456 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327569 | 111456 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | |||
| 44300615 | 196783 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL56549 | 196783 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10257584 | 17128 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 577 | 14 | 0 | 8 | 6.2 | CCCCCCN1C(=O)/C(=C/c2cnc(CCCC)n2Cc2ccc(C(=O)OC)cc2)N(Cc2csc(C)n2)C1=O | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125533 | 17128 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 577 | 14 | 0 | 8 | 6.2 | CCCCCCN1C(=O)/C(=C/c2cnc(CCCC)n2Cc2ccc(C(=O)OC)cc2)N(Cc2csc(C)n2)C1=O | 10.1007/s00044-009-9205-9 | |||
| 10168097 | 173062 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 587 | 11 | 1 | 9 | 5.7 | CCCCc1nc2ccn(Cc3ccccc3C(=O)OCC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| CHEMBL45195 | 173062 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 587 | 11 | 1 | 9 | 5.7 | CCCCc1nc2ccn(Cc3ccccc3C(=O)OCC)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | |||
| 10765180 | 10245 | 0 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 7 | 3 | 7 | 3.3 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL116094 | 10245 | 0 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 7 | 3 | 7 | 3.3 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 10004112 | 25530 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | |||
| CHEMBL135089 | 25530 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | |||
| 44277489 | 100413 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccncc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29020 | 100413 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccncc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 10439612 | 161855 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 688 | 10 | 1 | 7 | 6.8 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1 | 10.1021/jm00043a020 | |||
| CHEMBL414816 | 161855 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 688 | 10 | 1 | 7 | 6.8 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1 | 10.1021/jm00043a020 | |||
| 10439172 | 207483 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94355 | 207483 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | |||
| 14956758 | 106531 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314042 | 106531 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9931685 | 206084 | 0 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL85595 | 206084 | 0 | None | - | 1 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 9931685 | 206084 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL85595 | 206084 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | |||
| 44379335 | 120221 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352137 | 120221 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44379348 | 164921 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL422374 | 164921 | 0 | None | - | 0 | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10160805 | 204064 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 445 | 11 | 1 | 7 | 4.5 | CCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| CHEMBL70029 | 204064 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 445 | 11 | 1 | 7 | 4.5 | CCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 14956769 | 107116 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL316052 | 107116 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277443 | 100298 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28918 | 100298 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44310609 | 203753 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL67919 | 203753 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 10008962 | 119273 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343719 | 119273 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10369701 | 16295 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 529 | 12 | 0 | 7 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122494 | 16295 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 529 | 12 | 0 | 7 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956762 | 98830 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL278741 | 98830 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956762 | 98830 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL278741 | 98830 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44377123 | 119975 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349856 | 119975 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10100723 | 207448 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94176 | 207448 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44315282 | 96624 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263452 | 96624 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 10008962 | 119273 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343719 | 119273 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44379217 | 58149 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167929 | 58149 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10416957 | 111499 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327791 | 111499 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10372810 | 106202 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL313868 | 106202 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 135723852 | 139140 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787050 | 139140 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44274745 | 91789 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 633 | 8 | 3 | 8 | 6.3 | CC(=O)Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24111 | 91789 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 633 | 8 | 3 | 8 | 6.3 | CC(=O)Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10370801 | 48429 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155554 | 48429 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127035082 | 136511 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736262 | 136511 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 9984390 | 119541 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 11 | 1 | 8 | 4.8 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345826 | 119541 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 11 | 1 | 8 | 4.8 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 9888820 | 9967 | 36 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 428 | 8 | 2 | 6 | 4.5 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| CHEMBL114752 | 9967 | 36 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 428 | 8 | 2 | 6 | 4.5 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| 44376992 | 57120 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 4.1 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL164552 | 57120 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 4.1 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 9953638 | 85056 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 415 | 6 | 1 | 7 | 3.9 | COC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| CHEMBL22426 | 85056 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 415 | 6 | 1 | 7 | 3.9 | COC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| 9887844 | 163200 | 4 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm00061a016 | |||
| CHEMBL418226 | 163200 | 4 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm00061a016 | |||
| 14956802 | 206315 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87184 | 206315 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 19385729 | 50879 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15774 | 50879 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 15356434 | 101726 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 590 | 13 | 1 | 8 | 5.7 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL299557 | 101726 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 590 | 13 | 1 | 8 | 5.7 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 9869596 | 115264 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 8 | 5.1 | CCSc1nc2c(C)sc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL334838 | 115264 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 8 | 5.1 | CCSc1nc2c(C)sc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 44321050 | 206244 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 416 | 9 | 1 | 5 | 4.5 | CCCCN1N=C(CCC)C(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL86764 | 206244 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 416 | 9 | 1 | 5 | 4.5 | CCCCN1N=C(CCC)C(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O | 10.1016/S0960-894X(01)80290-0 | |||
| 15144942 | 117001 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 9 | 1 | 3 | 5.9 | CCCCc1ncc(/C=C(\Cc2ccccc2C)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL338813 | 117001 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 9 | 1 | 3 | 5.9 | CCCCc1ncc(/C=C(\Cc2ccccc2C)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 71653009 | 89155 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 12 | 3 | 4 | 6.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337685 | 89155 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 12 | 3 | 4 | 6.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2366019 | 89155 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 12 | 3 | 4 | 6.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 127035557 | 136431 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735558 | 136431 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44306646 | 203014 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL63280 | 203014 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 10646584 | 10257 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCc1nc(C(C)(O)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL116102 | 10257 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCc1nc(C(C)(O)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 22850667 | 200800 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL60071 | 200800 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 10050519 | 98509 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 5.3 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(Cl)cc(Cl)c3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL276150 | 98509 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 5.3 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(Cl)cc(Cl)c3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 11477098 | 206224 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 477 | 5 | 1 | 8 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c3nnnn3c3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86655 | 206224 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 477 | 5 | 1 | 8 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c3nnnn3c3ccccc23)cc1 | 10.1021/jm031100t | |||
| 19422629 | 98399 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 460 | 9 | 1 | 3 | 6.7 | CCCCC1=NC(CC)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL275437 | 98399 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 460 | 9 | 1 | 3 | 6.7 | CCCCC1=NC(CC)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 57380213 | 70527 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947128 | 70527 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 44305654 | 100782 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL293001 | 100782 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10071111 | 119641 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL346742 | 119641 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341786 | 165302 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 5 | 1 | 3 | 5.2 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2c2ccccc2)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL423325 | 165302 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 5 | 1 | 3 | 5.2 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2c2ccccc2)cc1 | 10.1021/jm00074a018 | |||
| 10071111 | 119641 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346742 | 119641 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 24827772 | 95788 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.3 | CCCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL258685 | 95788 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.3 | CCCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44297144 | 168017 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@H]4[C@@H]3ON3[C@@H]4CCC3(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL432128 | 168017 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@H]4[C@@H]3ON3[C@@H]4CCC3(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44288321 | 155199 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL40250 | 155199 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 127026042 | 137257 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 620 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3751986 | 137257 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 620 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127036867 | 137382 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753134 | 137382 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 15287884 | 155241 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccc(Cl)cc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40273 | 155241 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccc(Cl)cc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 15171420 | 206689 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccc(C)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL89614 | 206689 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccc(C)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44352199 | 22005 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 7 | 1 | 6 | 5.0 | CCCCc1nc2c(C)cncc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL132109 | 22005 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 7 | 1 | 6 | 5.0 | CCCCc1nc2c(C)cncc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 14950504 | 85490 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| CHEMBL22692 | 85490 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| 10052319 | 163335 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 12 | 1 | 7 | 4.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]cn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL419058 | 163335 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 12 | 1 | 7 | 4.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]cn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9807638 | 187146 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL49192 | 187146 | 0 | None | - | 1 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 11743916 | 119462 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 439 | 10 | 1 | 7 | 4.3 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345127 | 119462 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 439 | 10 | 1 | 7 | 4.3 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792121 | 189439 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51340 | 189439 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10363552 | 20615 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2ccc(N)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130828 | 20615 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2ccc(N)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 15699068 | 5364 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 | 10.1021/jm00114a021 | |||
| CHEMBL106934 | 5364 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(c1nnn[nH]1)C2 | 10.1021/jm00114a021 | |||
| 44303884 | 202833 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62422 | 202833 | 0 | None | - | 0 | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44459611 | 100091 | 0 | None | - | 0 | Bovine | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 568 | 7 | 2 | 7 | 5.9 | COc1ccc(-c2nc3cc(C4=NN(Cc5ccc(-c6ccccc6-c6nn[nH]n6)cc5)C(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL287374 | 100091 | 0 | None | - | 0 | Bovine | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 568 | 7 | 2 | 7 | 5.9 | COc1ccc(-c2nc3cc(C4=NN(Cc5ccc(-c6ccccc6-c6nn[nH]n6)cc5)C(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 19792121 | 189439 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51340 | 189439 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 127036868 | 137363 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753007 | 137363 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 10001717 | 48256 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 412 | 7 | 1 | 7 | 4.1 | CCCCc1nn2cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155305 | 48256 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 412 | 7 | 1 | 7 | 4.1 | CCCCc1nn2cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9985840 | 120023 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 426 | 8 | 1 | 7 | 4.3 | CCCCc1nn2cc(CC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL350241 | 120023 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 426 | 8 | 1 | 7 | 4.3 | CCCCc1nn2cc(CC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9930953 | 102802 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL305350 | 102802 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 3025727 | 184080 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL48242 | 184080 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 3025727 | 184080 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48242 | 184080 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44358531 | 119361 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 636 | 6 | 3 | 8 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3cc(Cl)c(S(N)(=O)=O)cc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL344388 | 119361 | 0 | None | - | 0 | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 636 | 6 | 3 | 8 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3cc(Cl)c(S(N)(=O)=O)cc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 3025727 | 184080 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL48242 | 184080 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 3025727 | 184080 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48242 | 184080 | 10 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44459759 | 99684 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 568 | 7 | 2 | 8 | 5.5 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL284546 | 99684 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 568 | 7 | 2 | 8 | 5.5 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 15662012 | 189329 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51246 | 189329 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15699052 | 109775 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2cccc(-c3nn[nH]n3)c2c1 | 10.1021/jm00114a021 | |||
| CHEMBL323179 | 109775 | 0 | None | - | 0 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2cccc(-c3nn[nH]n3)c2c1 | 10.1021/jm00114a021 | |||
| 44291477 | 101346 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL296883 | 101346 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 9888865 | 57497 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL165974 | 57497 | 0 | None | - | 0 | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| 127035084 | 136383 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 707 | 13 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735151 | 136383 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 707 | 13 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 44291477 | 101346 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL296883 | 101346 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 406 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(CC)(CC)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 18942290 | 193616 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 558 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc(C3=NN4CCCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL52700 | 193616 | 0 | None | - | 0 | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 558 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc(C3=NN4CCCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15654747 | 203832 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.4 | CCCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL68516 | 203832 | 0 | None | - | 0 | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.4 | CCCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15662012 | 189329 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51246 | 189329 | 0 | None | - | 0 | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 76315365 | 84948 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 11 | 3 | 8 | 4.0 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237580 | 84948 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 11 | 3 | 8 | 4.0 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10078057 | 50634 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 492 | 10 | 2 | 7 | 4.4 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157512 | 50634 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 492 | 10 | 2 | 7 | 4.4 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44358303 | 30876 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2N2N=C(c3ccccc3)N[S+]2[O-])cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL139739 | 30876 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2N2N=C(c3ccccc3)N[S+]2[O-])cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 15287887 | 145192 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 460 | 9 | 1 | 7 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2[N+](=O)[O-])cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL39124 | 145192 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 460 | 9 | 1 | 7 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2[N+](=O)[O-])cc1 | 10.1016/0960-894X(94)00476-V | |||
| 127034920 | 136531 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736451 | 136531 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 46910582 | 70353 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945009 | 70353 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127036107 | 136516 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736319 | 136516 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 9940350 | 204758 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| CHEMBL74573 | 204758 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| 10072002 | 115243 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2c(NC(C)=O)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL334741 | 115243 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2c(NC(C)=O)cccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 11328411 | 106167 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL313718 | 106167 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 6 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(CC(=O)O)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 10786794 | 162892 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL417366 | 162892 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10786794 | 162892 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL417366 | 162892 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15654757 | 102227 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 494 | 7 | 2 | 7 | 4.6 | O=C(O)c1cccc2nc(OCC(F)(F)F)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| CHEMBL302973 | 102227 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 494 | 7 | 2 | 7 | 4.6 | O=C(O)c1cccc2nc(OCC(F)(F)F)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| 15654752 | 102254 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 3.8 | COCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL303170 | 102254 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 3.8 | COCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44295010 | 187244 | 0 | None | - | 1 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL49262 | 187244 | 0 | None | - | 1 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 54768877 | 65120 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 535 | 9 | 1 | 8 | 5.2 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(CC)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824003 | 65120 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 535 | 9 | 1 | 8 | 5.2 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(CC)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 14951089 | 102943 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 583 | 12 | 1 | 8 | 6.0 | CCCCc1nn(C(Cc2ccccc2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL306328 | 102943 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 583 | 12 | 1 | 8 | 6.0 | CCCCc1nn(C(Cc2ccccc2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44341597 | 9959 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 505 | 9 | 2 | 5 | 3.8 | CCCCC1=NC2(CCN(C(=O)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114710 | 9959 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 505 | 9 | 2 | 5 | 3.8 | CCCCC1=NC2(CCN(C(=O)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44315350 | 105218 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311484 | 105218 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10275744 | 206118 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL85876 | 206118 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 44293656 | 188013 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 514 | 13 | 2 | 7 | 5.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](CCCC)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49748 | 188013 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 514 | 13 | 2 | 7 | 5.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)[C@H](CCCC)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 15780089 | 99809 | 0 | None | - | 0 | Rabbit | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL285432 | 99809 | 0 | None | - | 0 | Rabbit | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44303887 | 203321 | 0 | None | - | 0 | Rabbit | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64861 | 203321 | 0 | None | - | 0 | Rabbit | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 71521194 | 86812 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 4 | 2 | 6 | 3.7 | CCc1nc2cc[nH]c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322177 | 86812 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 4 | 2 | 6 | 3.7 | CCc1nc2cc[nH]c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 24828038 | 159455 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 424 | 7 | 1 | 6 | 4.5 | CCCCn1c(=O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410125 | 159455 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 424 | 7 | 1 | 6 | 4.5 | CCCCn1c(=O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 19087866 | 98936 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL279515 | 98936 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956801 | 206110 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85765 | 206110 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 60165459 | 105251 | 7 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 566 | 10 | 1 | 7 | 7.7 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115247 | 105251 | 7 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 566 | 10 | 1 | 7 | 7.7 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| 44277594 | 101803 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30015 | 101803 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44306651 | 100540 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 533 | 3 | 1 | 4 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL291358 | 100540 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 533 | 3 | 1 | 4 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 3081289 | 10024 | 11 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL115021 | 10024 | 11 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 6918269 | 98470 | 11 | None | 776 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL275875 | 98470 | 11 | None | 776 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL295959 | 98470 | 11 | None | 776 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 19771826 | 206625 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(C)=O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL89143 | 206625 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(C)=O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 9895957 | 10673 | 18 | None | -5 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1039/C4MD00499J | |||
| CHEMBL11706 | 10673 | 18 | None | -5 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1039/C4MD00499J | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 108185 | 1614 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | |||
| 586 | 1614 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | |||
| CHEMBL907 | 1614 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | |||
| 15236334 | 165600 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL424289 | 165600 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 108185 | 1614 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| 586 | 1614 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| CHEMBL907 | 1614 | 78 | None | - | 1 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| 10394727 | 103062 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL307321 | 103062 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311650 | 103201 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308361 | 103201 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311607 | 204183 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70770 | 204183 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222103 | 204539 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72819 | 204539 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 3081289 | 10024 | 11 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL115021 | 10024 | 11 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44376760 | 165394 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 11 | 3 | 6 | 4.7 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL423801 | 165394 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 11 | 3 | 6 | 4.7 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 14950498 | 99024 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 7 | 1 | 6 | 5.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL280189 | 99024 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 7 | 1 | 6 | 5.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 14950505 | 99157 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 433 | 6 | 1 | 5 | 5.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL281192 | 99157 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 433 | 6 | 1 | 5 | 5.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 44341922 | 10417 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 2 | 5 | 3.6 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(N)=O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL116298 | 10417 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 2 | 5 | 3.6 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(N)=O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 9888876 | 48990 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15606 | 48990 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 10437754 | 119709 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347404 | 119709 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76319527 | 85404 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 514 | 11 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2c2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2263317 | 85404 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 514 | 11 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2c2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10437754 | 119709 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347404 | 119709 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10394859 | 17429 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL125760 | 17429 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 127029976 | 139217 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3786145 | 139217 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787767 | 139217 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 44376781 | 56272 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL162859 | 56272 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44305663 | 100999 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL294358 | 100999 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 127034922 | 136363 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734891 | 136363 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44274823 | 99075 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL280526 | 99075 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10076191 | 118451 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 548 | 13 | 0 | 6 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC(F)(F)F)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341151 | 118451 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 548 | 13 | 0 | 6 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC(F)(F)F)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277874 | 99554 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 629 | 11 | 0 | 9 | 6.9 | CCCCCN(C(=O)c1ccc(SC)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28359 | 99554 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 629 | 11 | 0 | 9 | 6.9 | CCCCCN(C(=O)c1ccc(SC)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44459903 | 99502 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.3 | CCCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL283292 | 99502 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.3 | CCCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 9931685 | 206084 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL85595 | 206084 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 44277481 | 101571 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 647 | 9 | 1 | 9 | 5.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(C(=O)O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29853 | 101571 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 647 | 9 | 1 | 9 | 5.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(C(=O)O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9932483 | 207843 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL9642 | 207843 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44358381 | 29359 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 6 | 2 | 8 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3cc(S(N)(=O)=O)c(Cl)cc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL138358 | 29359 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 6 | 2 | 8 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3cc(S(N)(=O)=O)c(Cl)cc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 19029589 | 118768 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 6 | 1 | 7 | 3.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2CC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL34190 | 118768 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 6 | 1 | 7 | 3.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2CC2)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 76311802 | 84963 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237595 | 84963 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10048770 | 118394 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341070 | 118394 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956740 | 205808 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL83248 | 205808 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9984360 | 119620 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346542 | 119620 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44277574 | 101901 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30086 | 101901 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm031100t | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 10053499 | 48791 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155877 | 48791 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10482258 | 119675 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347135 | 119675 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 9888159 | 106966 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cn2)n1 | 10.1021/jm031100t | |||
| CHEMBL315022 | 106966 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cn2)n1 | 10.1021/jm031100t | |||
| 44348259 | 16032 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122367 | 16032 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | |||
| 10053499 | 48791 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155877 | 48791 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10482258 | 119675 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347135 | 119675 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 71520500 | 86810 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 541 | 6 | 1 | 7 | 5.8 | CCc1nc2c(C)cn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322175 | 86810 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 541 | 6 | 1 | 7 | 5.8 | CCc1nc2c(C)cn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 53309274 | 63776 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.2 | CCc1cc(C)c2nc(CC)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801738 | 63776 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.2 | CCc1cc(C)c2nc(CC)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 44277442 | 100297 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28917 | 100297 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 132706 | 1676 | 24 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1021/jm031100t | |||
| 6896 | 1676 | 24 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1021/jm031100t | |||
| CHEMBL315021 | 1676 | 24 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1021/jm031100t | |||
| DB01342 | 1676 | 24 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1021/jm031100t | |||
| 10344235 | 206160 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL86247 | 206160 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 132706 | 1676 | 24 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| 6896 | 1676 | 24 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL315021 | 1676 | 24 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| DB01342 | 1676 | 24 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| 10344235 | 206160 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm7011563 | |||
| CHEMBL86247 | 206160 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm7011563 | |||
| 15224471 | 154833 | 0 | None | - | 1 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL400424 | 154833 | 0 | None | - | 1 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10645687 | 10172 | 0 | None | - | 0 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115946 | 10172 | 0 | None | - | 0 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 10368143 | 46759 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL153968 | 46759 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10459507 | 47725 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154772 | 47725 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956775 | 203981 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL69508 | 203981 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 76310610 | 105250 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 10 | 1 | 5 | 8.2 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115246 | 105250 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 10 | 1 | 5 | 8.2 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| 44293815 | 184247 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 549 | 11 | 2 | 6 | 6.4 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48363 | 184247 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 549 | 11 | 2 | 6 | 6.4 | CCCCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341824 | 10016 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.5 | CCCCC1=NC2(Cc3ccccc3C2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114983 | 10016 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 5.5 | CCCCC1=NC2(Cc3ccccc3C2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19889356 | 179897 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| CHEMBL47459 | 179897 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1021/jm031100t | |||
| 44348332 | 15536 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL121871 | 15536 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| 44348323 | 16458 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 445 | 7 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(C)CC | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL123348 | 16458 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 445 | 7 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(C)CC | 10.1016/S0960-894X(01)80914-8 | |||
| 10368143 | 46759 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL153968 | 46759 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10459507 | 47725 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154772 | 47725 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19889356 | 179897 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL47459 | 179897 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 10642523 | 110466 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL324729 | 110466 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 9982103 | 115155 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C#N)cccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL334431 | 115155 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C#N)cccc2n1 | 10.1021/jm00100a007 | |||
| 44341924 | 11325 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 11 | 2 | 5 | 5.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](CC1CCCCC1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL117941 | 11325 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 11 | 2 | 5 | 5.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](CC1CCCCC1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 11561462 | 111133 | 61 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 10 | 1 | 6 | 4.3 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)OC)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL326349 | 111133 | 61 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 10 | 1 | 6 | 4.3 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)OC)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 15287885 | 161815 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc(Cl)c2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41440 | 161815 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc(Cl)c2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 15699054 | 109485 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 | 10.1021/jm00114a021 | |||
| CHEMBL322071 | 109485 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 396 | 7 | 2 | 6 | 3.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2cc(-c3nn[nH]n3)ccc2c1 | 10.1021/jm00114a021 | |||
| 24828034 | 166430 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 3.7 | CCCCn1c(=O)c2ccc(N3CCOCC3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL427738 | 166430 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 3.7 | CCCCn1c(=O)c2ccc(N3CCOCC3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 19792191 | 98378 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL275304 | 98378 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10503729 | 9685 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 9 | 2 | 6 | 4.7 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL113040 | 9685 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 9 | 2 | 6 | 4.7 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 11741515 | 116843 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 397 | 7 | 1 | 3 | 6.1 | CCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL338048 | 116843 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 397 | 7 | 1 | 3 | 6.1 | CCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 21840429 | 110920 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 393 | 9 | 2 | 5 | 3.1 | CCCCC(=O)N(CC(=O)O)Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL326140 | 110920 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 393 | 9 | 2 | 5 | 3.1 | CCCCC(=O)N(CC(=O)O)Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81117-3 | |||
| 44298570 | 101014 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2c(C)cccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL294485 | 101014 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2c(C)cccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44298809 | 195513 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 6 | 1 | 7 | 4.2 | Cc1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL55366 | 195513 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 6 | 1 | 7 | 4.2 | Cc1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| 19792191 | 98378 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL275304 | 98378 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 18572337 | 81157 | 9 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 419 | 6 | 0 | 9 | 3.5 | O=C(Oc1coc(CSc2ncccn2)cc1=O)c1cc([N+](=O)[O-])ccc1Cl | 10.1016/j.bmcl.2012.08.105 | |||
| CHEMBL2158005 | 81157 | 9 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 419 | 6 | 0 | 9 | 3.5 | O=C(Oc1coc(CSc2ncccn2)cc1=O)c1cc([N+](=O)[O-])ccc1Cl | 10.1016/j.bmcl.2012.08.105 | |||
| 127035248 | 136441 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735653 | 136441 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 9937461 | 101823 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL300279 | 101823 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 127035263 | 136460 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735804 | 136460 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44341836 | 110413 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 470 | 7 | 1 | 3 | 6.2 | CCCCC1=NC2(C(=O)N1Cc1ccc(-c3ccccc3C(=O)O)cc1)C1CC3CC(C1)CC2C3 | 10.1021/jm00074a018 | |||
| CHEMBL324452 | 110413 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 470 | 7 | 1 | 3 | 6.2 | CCCCC1=NC2(C(=O)N1Cc1ccc(-c3ccccc3C(=O)O)cc1)C1CC3CC(C1)CC2C3 | 10.1021/jm00074a018 | |||
| 15654703 | 204308 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 4.1 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71410 | 204308 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 4.1 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44305663 | 100999 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL294358 | 100999 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 19385598 | 98862 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278955 | 98862 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | |||
| 135723843 | 100957 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 468 | 8 | 2 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL294140 | 100957 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 468 | 8 | 2 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 15654753 | 204227 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.5 | CSCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL70947 | 204227 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.5 | CSCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 127035393 | 136391 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735227 | 136391 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 76315369 | 84977 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 522 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237609 | 84977 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 522 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10005344 | 47171 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 11 | 1 | 7 | 5.1 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154315 | 47171 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 11 | 1 | 7 | 5.1 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44320816 | 206274 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 414 | 10 | 1 | 5 | 5.5 | CCCCc1cn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CCCC)n1 | 10.1016/S0960-894X(01)80290-0 | |||
| CHEMBL86935 | 206274 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 414 | 10 | 1 | 5 | 5.5 | CCCCc1cn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CCCC)n1 | 10.1016/S0960-894X(01)80290-0 | |||
| 71521585 | 86809 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 532 | 6 | 1 | 9 | 4.8 | CCc1nc2ccn(Cc3c(C)noc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322174 | 86809 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 532 | 6 | 1 | 9 | 4.8 | CCc1nc2ccn(Cc3c(C)noc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 71521505 | 86835 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccccn3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322451 | 86835 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccccn3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 70684421 | 76634 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063980 | 76634 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 9979266 | 117293 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 379 | 5 | 1 | 5 | 4.7 | c1ccc(-c2nn[nH]n2)c(-c2ccc(COc3ccnc4ccccc34)cc2)c1 | 10.1021/jm00100a007 | |||
| CHEMBL339592 | 117293 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 379 | 5 | 1 | 5 | 4.7 | c1ccc(-c2nn[nH]n2)c(-c2ccc(COc3ccnc4ccccc34)cc2)c1 | 10.1021/jm00100a007 | |||
| 70684421 | 76634 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063980 | 76634 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 71654380 | 89157 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 657 | 12 | 3 | 8 | 6.1 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337680 | 89157 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 657 | 12 | 3 | 8 | 6.1 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2366021 | 89157 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 657 | 12 | 3 | 8 | 6.1 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44315344 | 105081 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311386 | 105081 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19036230 | 101754 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 9 | 3 | 5 | 3.8 | CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL299809 | 101754 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 9 | 3 | 5 | 3.8 | CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15287883 | 98210 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL274260 | 98210 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 15654760 | 102192 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 467 | 9 | 3 | 7 | 4.8 | CCCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL302811 | 102192 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 467 | 9 | 3 | 7 | 4.8 | CCCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44342002 | 9949 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 5.9 | CCCCC1=NC2(CCC(C)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114656 | 9949 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 5.9 | CCCCC1=NC2(CCC(C)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 11352388 | 105945 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 6.4 | CCCNc1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O | 10.1021/jm031100t | |||
| CHEMBL312889 | 105945 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 493 | 8 | 2 | 6 | 6.4 | CCCNc1nc2ccccc2c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1C(=O)O | 10.1021/jm031100t | |||
| 9983514 | 19481 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)OC)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL129872 | 19481 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)OC)ccc2n1 | 10.1021/jm00100a007 | |||
| 15654696 | 103779 | 65 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 7 | 1 | 8 | 4.1 | CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL308884 | 103779 | 65 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 7 | 1 | 8 | 4.1 | CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44341698 | 159936 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 442 | 7 | 0 | 6 | 4.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL410724 | 159936 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 442 | 7 | 0 | 6 | 4.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C)n2)cc1 | 10.1021/jm00074a018 | |||
| 44295673 | 162779 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL417196 | 162779 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 44295673 | 162779 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL417196 | 162779 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 44305289 | 203277 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 2.7 | CCCc1c(C)c(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL64670 | 203277 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 2.7 | CCCc1c(C)c(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 18654313 | 63770 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801713 | 63770 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 15171411 | 206202 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3cc(OC)ccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL86495 | 206202 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3cc(OC)ccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 71521419 | 86831 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3cccc(F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322448 | 86831 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3cccc(F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 127026041 | 137530 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3754267 | 137530 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44293911 | 188242 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 11 | 2 | 6 | 5.9 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49954 | 188242 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 11 | 2 | 6 | 5.9 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2)cc1 | 10.1021/jm00064a007 | |||
| 127035381 | 136473 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735940 | 136473 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 14956800 | 206150 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86143 | 206150 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 22850890 | 189774 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL51606 | 189774 | 0 | None | - | 0 | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44294562 | 189146 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51078 | 189146 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44563175 | 189093 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 570 | 7 | 1 | 5 | 8.6 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc(Cl)[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL510065 | 189093 | 0 | None | - | 0 | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 570 | 7 | 1 | 5 | 8.6 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc(Cl)[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 14956746 | 206194 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86440 | 206194 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44270285 | 99065 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL280456 | 99065 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 127026040 | 137479 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 11 | 3 | 8 | 4.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753888 | 137479 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 11 | 3 | 8 | 4.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44298833 | 198509 | 0 | None | - | 0 | Bovine | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 482 | 7 | 2 | 8 | 3.6 | CC(C)Oc1nc2ccc(C(=O)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL57781 | 198509 | 0 | None | - | 0 | Bovine | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 482 | 7 | 2 | 8 | 3.6 | CC(C)Oc1nc2ccc(C(=O)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 127035249 | 136521 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736346 | 136521 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44274733 | 99407 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 482 | 8 | 1 | 7 | 5.4 | CCCCc1nc2ccc(SC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL282746 | 99407 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 482 | 8 | 1 | 7 | 5.4 | CCCCc1nc2ccc(SC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 15171415 | 106938 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(Cl)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL314859 | 106938 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(Cl)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 127035757 | 136505 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 10 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736242 | 136505 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 10 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 71520501 | 86811 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 552 | 6 | 1 | 8 | 5.4 | CCc1nc2c(C)cn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322176 | 86811 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 552 | 6 | 1 | 8 | 5.4 | CCc1nc2c(C)cn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44376991 | 120295 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL352675 | 120295 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10075750 | 107558 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL318891 | 107558 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 9851889 | 102074 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL302102 | 102074 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 19010079 | 84956 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 524 | 11 | 2 | 8 | 5.4 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237588 | 84956 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 524 | 11 | 2 | 8 | 5.4 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10367792 | 17941 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 478 | 9 | 1 | 7 | 4.2 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125958 | 17941 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 478 | 9 | 1 | 7 | 4.2 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9981102 | 164192 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL421074 | 164192 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10096735 | 119530 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 1 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345717 | 119530 | 0 | None | - | 0 | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 1 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44277873 | 98872 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 11 | 0 | 10 | 5.5 | CCCCCN(C(=O)c1ccc(S(C)(=O)=O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL27903 | 98872 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 11 | 0 | 10 | 5.5 | CCCCCN(C(=O)c1ccc(S(C)(=O)=O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44342039 | 10293 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL116170 | 10293 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19029573 | 120719 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 405 | 5 | 1 | 7 | 2.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(C)=O)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL35475 | 120719 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 405 | 5 | 1 | 7 | 2.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(C)=O)s1 | 10.1016/S0960-894X(96)00250-8 | |||
| 44314780 | 103078 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307430 | 103078 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 127034921 | 136528 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736440 | 136528 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44291781 | 181558 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 8 | 1 | 3 | 5.4 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47669 | 181558 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 8 | 1 | 3 | 5.4 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 1037 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 3940 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 5281037 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 588 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| DB00876 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 11757193 | 51349 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL158133 | 51349 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 2806 | 3969 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 3937 | 3969 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 593 | 3969 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 60846 | 3969 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL1069 | 3969 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| DB00177 | 3969 | 110 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 11757193 | 51349 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158133 | 51349 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44379269 | 57168 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164769 | 57168 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44376779 | 56503 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 11 | 3 | 6 | 3.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163485 | 56503 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 11 | 3 | 6 | 3.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44277549 | 99128 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280988 | 99128 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44300637 | 100925 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL293949 | 100925 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10436523 | 119463 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345139 | 119463 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10436523 | 119463 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345139 | 119463 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44274716 | 96868 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26548 | 96868 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 54178446 | 63769 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801712 | 63769 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 44291782 | 183417 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 456 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL47985 | 183417 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 456 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(C2CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 14956755 | 106149 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL313579 | 106149 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10202093 | 206435 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87985 | 206435 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 11443112 | 106631 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 6.6 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(Cl)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL314315 | 106631 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 6.6 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(Cl)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 158781 | 44166 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1516 | 44166 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10048120 | 119492 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 4.4 | CCCCc1nn2c(C)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345404 | 119492 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 4.4 | CCCCc1nn2c(C)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 14951059 | 206429 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL87942 | 206429 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10346399 | 47583 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154640 | 47583 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11758329 | 116915 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 12 | 0 | 8 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC(F)(F)F)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL338431 | 116915 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 12 | 0 | 8 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC(F)(F)F)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956776 | 105968 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL313017 | 105968 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10346399 | 47583 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154640 | 47583 | 0 | None | - | 0 | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 24828705 | 157702 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 443 | 7 | 1 | 7 | 4.0 | CCCCn1c(=O)c2cc(F)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL408188 | 157702 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 443 | 7 | 1 | 7 | 4.0 | CCCCn1c(=O)c2cc(F)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 127036108 | 136378 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735098 | 136378 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10368898 | 18897 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 469 | 9 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCCF)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128389 | 18897 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 469 | 9 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCCF)ccc2n1 | 10.1021/jm00100a007 | |||
| 9932352 | 16914 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 6.0 | CCCCc1ncc(/C=C(\Cc2ccc(C)s2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL125212 | 16914 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 6.0 | CCCCc1ncc(/C=C(\Cc2ccc(C)s2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 44341797 | 110639 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 362 | 4 | 1 | 3 | 4.1 | CC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325751 | 110639 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 362 | 4 | 1 | 3 | 4.1 | CC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 44274706 | 96752 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 518 | 8 | 2 | 6 | 5.5 | CCCCc1nc2cc(C3=NN(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)C(=O)CC3C)ccc2[nH]1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL26449 | 96752 | 0 | None | - | 0 | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 518 | 8 | 2 | 6 | 5.5 | CCCCc1nc2cc(C3=NN(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)C(=O)CC3C)ccc2[nH]1 | 10.1016/S0960-894X(01)80348-6 | |||
| 71653750 | 89151 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 11 | 2 | 7 | 6.7 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337679 | 89151 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 11 | 2 | 7 | 6.7 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365906 | 89151 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 11 | 2 | 7 | 6.7 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44289028 | 101183 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.5 | CCCCC1=NCC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| CHEMBL295646 | 101183 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 418 | 7 | 1 | 3 | 5.5 | CCCCC1=NCC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81139-2 | |||
| 10320063 | 18142 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 10 | 1 | 7 | 4.1 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(F)ccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12693 | 18142 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 10 | 1 | 7 | 4.1 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(F)ccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00053a013 | |||
| 76329881 | 84953 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 490 | 11 | 2 | 8 | 4.9 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237585 | 84953 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 490 | 11 | 2 | 8 | 4.9 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 15780085 | 118150 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL34082 | 118150 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9981071 | 119467 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 447 | 10 | 1 | 7 | 5.3 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345181 | 119467 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 447 | 10 | 1 | 7 | 5.3 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10345129 | 49117 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156181 | 49117 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10345129 | 49117 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156181 | 49117 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792156 | 189995 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51712 | 189995 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792156 | 189995 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51712 | 189995 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 71611145 | 184862 | 2 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4852514 | 184862 | 2 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 127036866 | 137269 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752117 | 137269 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127028930 | 137304 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 570 | 9 | 3 | 7 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752444 | 137304 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 570 | 9 | 3 | 7 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44341488 | 9478 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 532 | 10 | 2 | 5 | 4.7 | CCCCC1=NC2(CCN(C(=O)C(N)C(C)CC)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL111968 | 9478 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 532 | 10 | 2 | 5 | 4.7 | CCCCC1=NC2(CCN(C(=O)C(N)C(C)CC)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10455288 | 16854 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 6.0 | CCCCc1ncc(/C=C(\Cc2sccc2C)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL124859 | 16854 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 428 | 9 | 1 | 4 | 6.0 | CCCCc1ncc(/C=C(\Cc2sccc2C)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 127034904 | 136463 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735831 | 136463 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 11155548 | 206418 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(OC)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL87884 | 206418 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 466 | 6 | 1 | 6 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(OC)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 15069406 | 101748 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299753 | 101748 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15069406 | 101748 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299753 | 101748 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 53309405 | 63780 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(CC(C)C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801742 | 63780 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(CC(C)C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 10323718 | 119527 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345696 | 119527 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10323718 | 119527 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345696 | 119527 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 127035380 | 136526 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736414 | 136526 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 24827904 | 96436 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2cc(Cl)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL262098 | 96436 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2cc(Cl)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44297202 | 101750 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 623 | 9 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccccc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL299770 | 101750 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 623 | 9 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccccc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44292497 | 14780 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL1206677 | 14780 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL295174 | 14780 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| 44287133 | 137609 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(c2ccccc2)c2nnn[nH]2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL37565 | 137609 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(c2ccccc2)c2nnn[nH]2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 10457332 | 51421 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL158196 | 51421 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10457332 | 51421 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158196 | 51421 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 46910581 | 76334 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058863 | 76334 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10416836 | 107904 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319313 | 107904 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | |||
| 70690562 | 76327 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058856 | 76327 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 76319036 | 84980 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 537 | 12 | 3 | 9 | 4.7 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237612 | 84980 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 537 | 12 | 3 | 9 | 4.7 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44307107 | 98695 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 417 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL277614 | 98695 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 417 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 10435850 | 48611 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 494 | 11 | 2 | 8 | 5.1 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155724 | 48611 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 494 | 11 | 2 | 8 | 5.1 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 127035391 | 136411 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735390 | 136411 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 14956774 | 206238 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86741 | 206238 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15780095 | 98595 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL276853 | 98595 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44297217 | 101569 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 10 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL298509 | 101569 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 10 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 135723817 | 100769 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 470 | 8 | 2 | 8 | 5.0 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL292914 | 100769 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 470 | 8 | 2 | 8 | 5.0 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 44274692 | 96446 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26217 | 96446 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10324870 | 113313 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 12 | 0 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cscn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331546 | 113313 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 12 | 0 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cscn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 11758341 | 117283 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339544 | 117283 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44306652 | 203342 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 437 | 3 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL64983 | 203342 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 437 | 3 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44311584 | 102780 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305239 | 102780 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 19771800 | 206380 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL87603 | 206380 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 20747575 | 98424 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 579 | 12 | 2 | 8 | 5.0 | CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 | 10.1039/C4MD00499J | |||
| CHEMBL275545 | 98424 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 579 | 12 | 2 | 8 | 5.0 | CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 | 10.1039/C4MD00499J | |||
| 127035085 | 136432 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 12 | 2 | 7 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735574 | 136432 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 12 | 2 | 7 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 44285327 | 168601 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 430 | 6 | 1 | 6 | 3.6 | CCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL435953 | 168601 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 430 | 6 | 1 | 6 | 3.6 | CCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44311496 | 204244 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL71069 | 204244 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379350 | 120785 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL355443 | 120785 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 9843950 | 100571 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 8 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL291582 | 100571 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 8 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 14950510 | 85695 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(C)=O)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22879 | 85695 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(C)=O)c(C)n1 | 10.1021/jm00061a016 | |||
| 15171369 | 99466 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCC2 | 10.1021/jm00061a016 | |||
| CHEMBL283110 | 99466 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCC2 | 10.1021/jm00061a016 | |||
| 10345638 | 20512 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 8 | 2 | 6 | 5.4 | CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130746 | 20512 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 8 | 2 | 6 | 5.4 | CCCCc1nc2ccc(NC(=O)N(C)C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00077a007 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 19385601 | 51916 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 1 | 5 | 6.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1Cl | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15860 | 51916 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 1 | 5 | 6.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1Cl | 10.1016/0960-894X(95)00185-V | |||
| 158781 | 44166 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1516 | 44166 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 158781 | 44166 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm950450f | |||
| CHEMBL1516 | 44166 | 98 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm950450f | |||
| 9874508 | 204680 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL73876 | 204680 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10223724 | 205757 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL82797 | 205757 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 53309271 | 63773 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 447 | 4 | 1 | 6 | 5.3 | Cc1cc(C)c2nc(C3CC3)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801735 | 63773 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 447 | 4 | 1 | 6 | 5.3 | Cc1cc(C)c2nc(C3CC3)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 10414273 | 114547 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 518 | 12 | 0 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccoc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333722 | 114547 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 518 | 12 | 0 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccoc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277872 | 96566 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 689 | 13 | 0 | 9 | 7.7 | CCCCCN(C(=O)c1ccc(OCc2ccccc2)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL263038 | 96566 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 689 | 13 | 0 | 9 | 7.7 | CCCCCN(C(=O)c1ccc(OCc2ccccc2)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10256564 | 16266 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 533 | 12 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)on2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122458 | 16266 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 533 | 12 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)on2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10391038 | 116932 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL338514 | 116932 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70694737 | 76218 | 0 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 544 | 10 | 1 | 7 | 6.5 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058372 | 76218 | 0 | None | - | 0 | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 544 | 10 | 1 | 7 | 6.5 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44342046 | 110548 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 6.1 | CCCCC1=NC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL325201 | 110548 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 432 | 7 | 1 | 3 | 6.1 | CCCCC1=NC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10226439 | 203876 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 459 | 12 | 1 | 7 | 4.9 | CCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| CHEMBL68760 | 203876 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 459 | 12 | 1 | 7 | 4.9 | CCCCCCn1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1021/jm00067a015 | |||
| 44376822 | 120053 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350493 | 120053 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10439858 | 16861 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL124903 | 16861 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44384872 | 59995 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL173455 | 59995 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 76322692 | 84973 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 585 | 12 | 2 | 10 | 4.3 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237605 | 84973 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 585 | 12 | 2 | 10 | 4.3 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10392565 | 168413 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 542 | 11 | 1 | 9 | 4.7 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL434844 | 168413 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 542 | 11 | 1 | 9 | 4.7 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44274824 | 99263 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL281846 | 99263 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956747 | 205974 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL84630 | 205974 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15356433 | 184004 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 548 | 12 | 3 | 6 | 5.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48195 | 184004 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 548 | 12 | 3 | 6 | 5.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 44341802 | 111366 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 6.1 | CCCCC1=NC2(CCCC2)C(=S)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL327018 | 111366 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 6.1 | CCCCC1=NC2(CCCC2)C(=S)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19422646 | 169444 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL44268 | 169444 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 19422646 | 169444 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| CHEMBL44268 | 169444 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 430 | 9 | 1 | 3 | 5.5 | CCCCC1=NC(C2CC2)(C2CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81140-9 | |||
| 15287893 | 161953 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 14 | 1 | 6 | 6.9 | CCCCCCOc1ccccc1C(Oc1ccc(Cn2c(CCC)nc3c(C)ccnc32)cc1)C(=O)O | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41566 | 161953 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 14 | 1 | 6 | 6.9 | CCCCCCOc1ccccc1C(Oc1ccc(Cn2c(CCC)nc3c(C)ccnc32)cc1)C(=O)O | 10.1016/0960-894X(94)00476-V | |||
| 44293697 | 100251 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 596 | 13 | 1 | 9 | 5.7 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL288753 | 100251 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 596 | 13 | 1 | 9 | 5.7 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)[C@H](Cc2cccs2)n2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 44341607 | 10046 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 534 | 10 | 3 | 6 | 3.1 | CCCCC1=NC2(CCN(C(=O)C(N)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL115204 | 10046 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 534 | 10 | 3 | 6 | 3.1 | CCCCC1=NC2(CCN(C(=O)C(N)CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 15654754 | 102078 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 3.3 | CNCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL302127 | 102078 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 3.3 | CNCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 11756569 | 116473 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2cc(NC(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL336130 | 116473 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2cc(NC(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 127035083 | 136356 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734835 | 136356 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 24827901 | 159428 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410105 | 159428 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 11754954 | 168392 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 481 | 8 | 1 | 4 | 6.3 | CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL434640 | 168392 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 481 | 8 | 1 | 4 | 6.3 | CCCCc1nc2ccc(N3CCCCC3=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 71521504 | 86834 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3cccc(C(F)(F)F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322450 | 86834 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3cccc(C(F)(F)F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44309398 | 102265 | 0 | None | - | 0 | Bovine | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 546 | 6 | 1 | 3 | 5.5 | CCCCc1nc2ccccc2n1CCc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL303247 | 102265 | 0 | None | - | 0 | Bovine | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 546 | 6 | 1 | 3 | 5.5 | CCCCc1nc2ccccc2n1CCc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44320733 | 206455 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 386 | 5 | 1 | 5 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2C(=O)O)cc1 | 10.1021/jm031100t | |||
| CHEMBL88081 | 206455 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 386 | 5 | 1 | 5 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ncccc2C(=O)O)cc1 | 10.1021/jm031100t | |||
| 127036865 | 137424 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753406 | 137424 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 15654743 | 168155 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 438 | 6 | 2 | 6 | 4.8 | CC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL433099 | 168155 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 438 | 6 | 2 | 6 | 4.8 | CC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44283175 | 120370 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL35324 | 120370 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10028815 | 208095 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97783 | 208095 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | |||
| 10250336 | 18886 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL128318 | 18886 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 44310590 | 204368 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL71730 | 204368 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 44305654 | 100782 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL293001 | 100782 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 71653748 | 89150 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 627 | 11 | 2 | 7 | 6.6 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2337678 | 89150 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 627 | 11 | 2 | 7 | 6.6 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365905 | 89150 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 627 | 11 | 2 | 7 | 6.6 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44293406 | 184867 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 458 | 10 | 2 | 7 | 3.6 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)Cn2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48526 | 184867 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 458 | 10 | 2 | 7 | 3.6 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(NC(=O)Cn2cccc2C(=O)OC)cc1 | 10.1021/jm00064a007 | |||
| 15654744 | 102147 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 6 | 2 | 6 | 4.5 | O=C(O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| CHEMBL302520 | 102147 | 0 | None | - | 0 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 6 | 2 | 6 | 4.5 | O=C(O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| 10502342 | 169075 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL439743 | 169075 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10502342 | 169075 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL439743 | 169075 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44287536 | 161925 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 381 | 9 | 1 | 5 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(CCC)C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41534 | 161925 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 381 | 9 | 1 | 5 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(CCC)C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 76328690 | 105246 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 7.7 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115242 | 105246 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 7.7 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44315059 | 204712 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74144 | 204712 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44307257 | 102600 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 326 | 4 | 1 | 6 | 3.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL304116 | 102600 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 326 | 4 | 1 | 6 | 3.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 135723836 | 101040 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 486 | 8 | 2 | 8 | 5.7 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL294598 | 101040 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 486 | 8 | 2 | 8 | 5.7 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 15654733 | 204337 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 8 | 4.3 | C=CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71550 | 204337 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 8 | 4.3 | C=CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10250278 | 20334 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| CHEMBL130600 | 20334 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 7 | 1 | 3 | 6.1 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00077a007 | |||
| 15288898 | 204279 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 280 | 5 | 1 | 3 | 4.1 | CCCCc1nc2ccccc2n1Cc1ccc(O)cc1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL71254 | 204279 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 280 | 5 | 1 | 3 | 4.1 | CCCCc1nc2ccccc2n1Cc1ccc(O)cc1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44303883 | 202902 | 0 | None | - | 0 | Rabbit | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62744 | 202902 | 0 | None | - | 0 | Rabbit | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 14950500 | 99574 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 4.3 | COCc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| CHEMBL283770 | 99574 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 4.3 | COCc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| 10457997 | 18835 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1021/jm00077a007 | |||
| CHEMBL128049 | 18835 | 1 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1021/jm00077a007 | |||
| 76308196 | 84994 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 8 | 3 | 6 | 3.9 | CCCCc1nnc(S)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237877 | 84994 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 8 | 3 | 6 | 3.9 | CCCCc1nnc(S)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10021888 | 49382 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 367 | 7 | 2 | 5 | 4.3 | CCCCc1nnc(S)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156408 | 49382 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 367 | 7 | 2 | 5 | 4.3 | CCCCc1nnc(S)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10346301 | 168386 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL434615 | 168386 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| 44373238 | 97087 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL267354 | 97087 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| 44300735 | 100760 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL292829 | 100760 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 127035558 | 136347 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734763 | 136347 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127026027 | 137273 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752145 | 137273 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 19792197 | 194934 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL54194 | 194934 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792197 | 194934 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL54194 | 194934 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10457516 | 16787 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 5.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(-c4nn[nH]n4)ccc3C(F)(F)F)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12451 | 16787 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 472 | 10 | 1 | 7 | 5.0 | CCCCc1nc(CCCC)n(Cc2ccc(-n3c(-c4nn[nH]n4)ccc3C(F)(F)F)cc2)n1 | 10.1021/jm00053a013 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 19919870 | 85261 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 604 | 13 | 0 | 6 | 7.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259781 | 85261 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 604 | 13 | 0 | 6 | 7.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 76315366 | 84949 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 11 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237581 | 84949 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 11 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 9986953 | 46593 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 506 | 10 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL153825 | 46593 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 506 | 10 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 76315367 | 84951 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.5 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237583 | 84951 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.5 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44341791 | 9972 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 419 | 7 | 2 | 4 | 4.1 | CCCCC1=NC2(CCNCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114771 | 9972 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 419 | 7 | 2 | 4 | 4.1 | CCCCC1=NC2(CCNCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 10002423 | 49227 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 5.9 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156279 | 49227 | 0 | None | - | 0 | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 5.9 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15699061 | 5308 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 376 | 7 | 2 | 4 | 3.6 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| CHEMBL106682 | 5308 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 376 | 7 | 2 | 4 | 3.6 | CCCCc1nc(Cl)c(CO)n1Cc1ccc2c(c1)CCC(C(=O)O)C2 | 10.1021/jm00114a021 | |||
| 44274772 | 98637 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL277182 | 98637 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10369902 | 164637 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL421629 | 164637 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44274772 | 98637 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL277182 | 98637 | 0 | None | - | 0 | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44311616 | 102140 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302485 | 102140 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311571 | 204455 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72249 | 204455 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 11328757 | 205967 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| CHEMBL84573 | 205967 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm031100t | |||
| 15171413 | 106958 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 6 | 1 | 5 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL314982 | 106958 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 6 | 1 | 5 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 15818746 | 124069 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL36324 | 124069 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44311567 | 103013 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306922 | 103013 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 14950509 | 83425 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL21968 | 83425 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| 14951064 | 203730 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 461 | 10 | 1 | 9 | 2.8 | CCCCc1nn(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL67764 | 203730 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 461 | 10 | 1 | 9 | 2.8 | CCCCc1nn(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 70684239 | 76217 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 528 | 9 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058371 | 76217 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 528 | 9 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 10763626 | 169551 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCn1ncc(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL443559 | 169551 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCn1ncc(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 10834137 | 10062 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115273 | 10062 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44277487 | 99272 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccn4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281891 | 99272 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccn4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 10457566 | 202802 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62269 | 202802 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 14956771 | 206353 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87392 | 206353 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277938 | 101149 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 4.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCC(=O)O)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29540 | 101149 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 4.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCC(=O)O)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9912098 | 108540 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 460 | 9 | 3 | 7 | 4.0 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL320135 | 108540 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 460 | 9 | 3 | 7 | 4.0 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 19385680 | 98881 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL279103 | 98881 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | |||
| 76330395 | 85412 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 567 | 12 | 0 | 9 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CSCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2263543 | 85412 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 567 | 12 | 0 | 9 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CSCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277593 | 99411 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282778 | 99411 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44277567 | 101397 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29725 | 101397 | 0 | None | - | 0 | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 10482886 | 15514 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 558 | 13 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121718 | 15514 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 558 | 13 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70694738 | 76219 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 548 | 9 | 1 | 6 | 7.2 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058373 | 76219 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 548 | 9 | 1 | 6 | 7.2 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 17748251 | 93347 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL245444 | 93347 | 0 | None | - | 1 | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(96)00250-8 | |||
| 14951069 | 203867 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 517 | 14 | 1 | 9 | 4.4 | CCCCc1nn(CCCCCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL68719 | 203867 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 517 | 14 | 1 | 9 | 4.4 | CCCCc1nn(CCCCCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 10006693 | 17043 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125454 | 17043 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70686382 | 76216 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 9 | 1 | 6 | 6.5 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058370 | 76216 | 0 | None | - | 0 | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 9 | 1 | 6 | 6.5 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44294551 | 184403 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL48459 | 184403 | 0 | None | - | 1 | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 76329883 | 84967 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237599 | 84967 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127026338 | 137404 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753277 | 137404 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 10482404 | 47460 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154531 | 47460 | 0 | None | - | 0 | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 24828427 | 96832 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c2nc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265208 | 96832 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c2nc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 9933179 | 18446 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 444 | 10 | 1 | 5 | 5.7 | CCCCc1ncc(/C=C(\Cc2ccc(OC)s2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| CHEMBL127194 | 18446 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 444 | 10 | 1 | 5 | 5.7 | CCCCc1ncc(/C=C(\Cc2ccc(OC)s2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00099a013 | |||
| 127036103 | 136509 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736257 | 136509 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 4286584 | 204946 | 10 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7641 | 204946 | 10 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44296954 | 101960 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 589 | 8 | 1 | 9 | 5.3 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301325 | 101960 | 0 | None | - | 0 | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 589 | 8 | 1 | 9 | 5.3 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15662011 | 193359 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52497 | 193359 | 0 | None | - | 0 | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10000596 | 20651 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 392 | 5 | 1 | 4 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2c1 | 10.1021/jm00100a007 | |||
| CHEMBL130858 | 20651 | 0 | None | - | 0 | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 392 | 5 | 1 | 4 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2c1 | 10.1021/jm00100a007 | |||
| 4286584 | 204946 | 10 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7641 | 204946 | 10 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15662011 | 193359 | 0 | None | - | 0 | Bovine | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52497 | 193359 | 0 | None | - | 0 | Bovine | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 14951065 | 203845 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 433 | 9 | 2 | 8 | 2.4 | CCCCc1nn(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| CHEMBL68582 | 203845 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 433 | 9 | 2 | 8 | 2.4 | CCCCc1nn(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a015 | |||
| 19792137 | 85366 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL2261752 | 85366 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792185 | 189446 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51349 | 189446 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792137 | 85366 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL2261752 | 85366 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792185 | 189446 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51349 | 189446 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44275059 | 100075 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 590 | 7 | 2 | 7 | 6.6 | Cc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL287253 | 100075 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 590 | 7 | 2 | 7 | 6.6 | Cc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44459584 | 96635 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26352 | 96635 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 15698058 | 187123 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL49170 | 187123 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 127035545 | 136369 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734955 | 136369 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 70686380 | 76212 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058366 | 76212 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| 44438900 | 147848 | 0 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL393305 | 147848 | 0 | None | - | 1 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 15171407 | 205991 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccc(Cl)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL84792 | 205991 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccc(Cl)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 127026337 | 137544 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3754394 | 137544 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 15287882 | 49743 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15670 | 49743 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 127034875 | 136352 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734819 | 136352 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10389251 | 47658 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154708 | 47658 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44293817 | 186377 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 11 | 2 | 5 | 6.7 | CCCCc1nc2c(C)cccc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| CHEMBL48756 | 186377 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 534 | 11 | 2 | 5 | 6.7 | CCCCc1nc2c(C)cccc2n1Cc1ccc(NC(=O)[C@H](Cc2ccccc2)n2cccc2C(=O)O)cc1 | 10.1021/jm00064a007 | |||
| 10389251 | 47658 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154708 | 47658 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15654718 | 102269 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL303264 | 102269 | 0 | None | - | 0 | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 76319034 | 84961 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 572 | 12 | 2 | 8 | 6.4 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237593 | 84961 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 572 | 12 | 2 | 8 | 6.4 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76322691 | 84964 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237596 | 84964 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127034916 | 136400 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 668 | 12 | 2 | 8 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735302 | 136400 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 668 | 12 | 2 | 8 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10052714 | 49188 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 529 | 11 | 1 | 7 | 6.9 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156243 | 49188 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 529 | 11 | 1 | 7 | 6.9 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10029367 | 50682 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157565 | 50682 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44296945 | 101996 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301569 | 101996 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 71521417 | 86829 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3ccccc3C(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322446 | 86829 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3ccccc3C(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44274747 | 99671 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 621 | 8 | 2 | 9 | 6.2 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccc([N+](=O)[O-])cc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL284469 | 99671 | 0 | None | - | 0 | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 621 | 8 | 2 | 9 | 6.2 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccc([N+](=O)[O-])cc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10475572 | 18615 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 391 | 10 | 1 | 4 | 5.4 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)n1 | 10.1021/jm00053a013 | |||
| CHEMBL12766 | 18615 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 391 | 10 | 1 | 4 | 5.4 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)n1 | 10.1021/jm00053a013 | |||
| 127034917 | 136535 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 654 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736507 | 136535 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 654 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 24828568 | 159605 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 424 | 7 | 1 | 5 | 4.8 | CCCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410325 | 159605 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 424 | 7 | 1 | 5 | 4.8 | CCCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44270367 | 163223 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL418354 | 163223 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44342001 | 9939 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 477 | 9 | 2 | 5 | 3.9 | CCCCC1=NC2(CCN(CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| CHEMBL114590 | 9939 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 477 | 9 | 2 | 5 | 3.9 | CCCCC1=NC2(CCN(CC(=O)O)CC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00074a018 | |||
| 4286584 | 204946 | 10 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL7641 | 204946 | 10 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 19008901 | 62643 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL178380 | 62643 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| 70688503 | 76329 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 601 | 11 | 2 | 8 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058858 | 76329 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 601 | 11 | 2 | 8 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10005096 | 18898 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(OC)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128397 | 18898 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(OC)c2n1 | 10.1021/jm00100a007 | |||
| 76317815 | 105249 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.6 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115245 | 105249 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.6 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 76311801 | 84960 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 10 | 2 | 8 | 5.7 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237592 | 84960 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 10 | 2 | 8 | 5.7 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19976416 | 206176 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ncccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| CHEMBL86344 | 206176 | 1 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ncccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm031100t | |||
| 10032367 | 53988 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 501 | 9 | 1 | 7 | 6.1 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL160573 | 53988 | 0 | None | - | 0 | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 501 | 9 | 1 | 7 | 6.1 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 22850888 | 194014 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL52791 | 194014 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 9894404 | 194669 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53174 | 194669 | 0 | None | - | 0 | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 132387 | 162334 | 23 | None | 9 | 3 | Rabbit | 10.3 | pKd | = | 10.3 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL416477 | 162334 | 23 | None | 9 | 3 | Rabbit | 10.3 | pKd | = | 10.3 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| 132387 | 162334 | 23 | None | 9 | 3 | Rabbit | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL416477 | 162334 | 23 | None | 9 | 3 | Rabbit | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| 192314 | 114500 | 28 | None | 15 | 3 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL1237157 | 114500 | 28 | None | 15 | 3 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL333534 | 114500 | 28 | None | 15 | 3 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| 15657904 | 187482 | 4 | None | - | 1 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49410 | 187482 | 4 | None | - | 1 | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| 10432780 | 164512 | 0 | None | 10 | 3 | Rabbit | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL421473 | 164512 | 0 | None | 10 | 3 | Rabbit | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 15657949 | 16915 | 0 | None | - | 1 | Rabbit | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 428 | 9 | 2 | 6 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL125218 | 16915 | 0 | None | - | 1 | Rabbit | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 428 | 9 | 2 | 6 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL5075338 | 214368 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | None | None | None | CCOC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H](C)NC(=O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||||
| CHEMBL266899 | 210707 | 0 | None | - | 1 | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9507744 | |||||
| 127030943 | 139195 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787243 | 139195 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787375 | 139195 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787700 | 139195 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 44348262 | 16343 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 469 | 6 | 1 | 6 | 4.0 | CCOC(=O)/C=C1\C2C3CCC(C3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL122891 | 16343 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 469 | 6 | 1 | 6 | 4.0 | CCOC(=O)/C=C1\C2C3CCC(C3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 9912059 | 185356 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL48602 | 185356 | 0 | None | - | 1 | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 10745817 | 119375 | 0 | None | - | 1 | Rat | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111973 | 119375 | 0 | None | - | 1 | Rat | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL344464 | 119375 | 0 | None | - | 1 | Rat | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL428475 | 213447 | 0 | None | - | 1 | Bovine | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| 10094936 | 16836 | 0 | None | 9 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL1237156 | 16836 | 0 | None | 9 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL124772 | 16836 | 0 | None | 9 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL216830 | 209342 | 30 | None | - | 1 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.8b00435 | |||||
| 127034873 | 136449 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735744 | 136449 | 0 | None | - | 1 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035715 | 136440 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735652 | 136440 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10408684 | 169172 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.7 | CCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL440521 | 169172 | 0 | None | - | 1 | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.7 | CCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| 44348285 | 16432 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL123208 | 16432 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294528 | 102038 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 440 | 8 | 1 | 9 | 3.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nnn2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL301819 | 102038 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 440 | 8 | 1 | 9 | 3.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nnn2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44294996 | 189793 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL51622 | 189793 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| 10629796 | 96884 | 0 | None | - | 1 | Bovine | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL265681 | 96884 | 0 | None | - | 1 | Bovine | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| 9957348 | 186725 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 493 | 9 | 1 | 8 | 5.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48868 | 186725 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 493 | 9 | 1 | 8 | 5.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 11744384 | 32347 | 0 | None | - | 1 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL141065 | 32347 | 0 | None | - | 1 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111972 | 32347 | 0 | None | - | 1 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| 44294791 | 183934 | 0 | None | - | 1 | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2nccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48145 | 183934 | 0 | None | - | 1 | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2nccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 9909542 | 177481 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL46392 | 177481 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 10365342 | 113495 | 0 | None | 16 | 2 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| CHEMBL331983 | 113495 | 0 | None | 16 | 2 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| 44383615 | 165951 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL425139 | 165951 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294551 | 184403 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL48459 | 184403 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| 9807638 | 187146 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49192 | 187146 | 0 | None | - | 1 | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294464 | 187789 | 0 | None | - | 1 | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 397 | 6 | 3 | 7 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c[nH]nc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49587 | 187789 | 0 | None | - | 1 | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 397 | 6 | 3 | 7 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c[nH]nc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 71623945 | 136464 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735839 | 136464 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44295057 | 101334 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL296731 | 101334 | 0 | None | - | 1 | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294699 | 187296 | 0 | None | - | 1 | Rabbit | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 501 | 9 | 1 | 8 | 5.1 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2Cc1ccccc1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49294 | 187296 | 0 | None | - | 1 | Rabbit | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 501 | 9 | 1 | 8 | 5.1 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2Cc1ccccc1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL408098 | 212700 | 0 | None | - | 1 | Bovine | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCCCCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC2=CCCC=C2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | |||||
| CHEMBL268804 | 210764 | 0 | None | -2 | 2 | Bovine | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| CHEMBL406519 | 212612 | 0 | None | - | 1 | Bovine | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 44348369 | 16336 | 0 | None | - | 1 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 495 | 6 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\C2C3C=CC(CCC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL122855 | 16336 | 0 | None | - | 1 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 495 | 6 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\C2C3C=CC(CCC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 16133225 | 419 | 52 | None | -1 | 4 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 172198 | 419 | 52 | None | -1 | 4 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 2504 | 419 | 52 | None | -1 | 4 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 45266664 | 419 | 52 | None | -1 | 4 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 5272 | 419 | 52 | None | -1 | 4 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| CHEMBL408403 | 419 | 52 | None | -1 | 4 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| DB11842 | 419 | 52 | None | -1 | 4 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9507744 | |||||
| 9912059 | 185356 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL48602 | 185356 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294466 | 187909 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 451 | 7 | 3 | 7 | 4.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)O)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49663 | 187909 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 451 | 7 | 3 | 7 | 4.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)O)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294483 | 101746 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL299741 | 101746 | 0 | None | - | 1 | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 15294417 | 184119 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 6 | 2 | 6 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48270 | 184119 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 6 | 2 | 6 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL415025 | 213169 | 0 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCSS[C@@H]2C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C | 10.1021/jm9507744 | |||||
| CHEMBL384349 | 212323 | 0 | None | -2 | 2 | Bovine | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | |||||
| CHEMBL402669 | 212529 | 0 | None | - | 1 | Bovine | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| CHEMBL406170 | 212597 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSS[C@@H]2C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C | 10.1021/jm9507744 | |||||
| 127035717 | 136416 | 0 | None | - | 1 | Rabbit | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735409 | 136416 | 0 | None | - | 1 | Rabbit | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10701559 | 155691 | 0 | None | - | 1 | Bovine | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1227 | 42 | 11 | 13 | 4.9 | CCCCCCCCCCCCCCCC(=O)OCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL405031 | 155691 | 0 | None | - | 1 | Bovine | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1227 | 42 | 11 | 13 | 4.9 | CCCCCCCCCCCCCCCC(=O)OCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| 44294540 | 101840 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 455 | 8 | 2 | 9 | 3.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(O)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL300438 | 101840 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 455 | 8 | 2 | 9 | 3.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(O)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 9864307 | 16426 | 0 | None | - | 1 | Rabbit | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 373 | 6 | 3 | 7 | 2.6 | O=C(O)c1cncnc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00098a018 | |||
| CHEMBL123152 | 16426 | 0 | None | - | 1 | Rabbit | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 373 | 6 | 3 | 7 | 2.6 | O=C(O)c1cncnc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00098a018 | |||
| 70682146 | 76331 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2058860 | 76331 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127036108 | 136378 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735098 | 136378 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035514 | 136423 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735446 | 136423 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44382928 | 59211 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL170196 | 59211 | 0 | None | - | 1 | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 9978737 | 118892 | 1 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111971 | 118892 | 1 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL342261 | 118892 | 1 | None | - | 1 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL415157 | 213174 | 0 | None | 10 | 2 | Bovine | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | |||||
| 127036107 | 136516 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736319 | 136516 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 127036297 | 136427 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735492 | 136427 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44382968 | 165223 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL422912 | 165223 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44295009 | 187171 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49207 | 187171 | 0 | None | - | 1 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294967 | 188355 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 467 | 9 | 1 | 8 | 4.6 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(CC)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL50109 | 188355 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 467 | 9 | 1 | 8 | 4.6 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(CC)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 155541125 | 172965 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| CHEMBL4517561 | 172965 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| 44295090 | 101654 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL299151 | 101654 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL264230 | 210609 | 0 | None | -3 | 2 | Bovine | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| 44294520 | 184288 | 0 | None | - | 1 | Rabbit | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nncc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48400 | 184288 | 0 | None | - | 1 | Rabbit | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nncc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294485 | 172568 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cc(C(=O)O)ccc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL448727 | 172568 | 0 | None | - | 1 | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cc(C(=O)O)ccc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44295010 | 187244 | 0 | None | - | 1 | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49262 | 187244 | 0 | None | - | 1 | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294515 | 191821 | 0 | None | - | 1 | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 501 | 9 | 1 | 9 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc([S+](C)[O-])n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL51987 | 191821 | 0 | None | - | 1 | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 501 | 9 | 1 | 9 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc([S+](C)[O-])n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44294676 | 187770 | 0 | None | - | 1 | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 451 | 7 | 1 | 7 | 4.7 | CCc1nc(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49573 | 187770 | 0 | None | - | 1 | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 451 | 7 | 1 | 7 | 4.7 | CCc1nc(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294616 | 188240 | 0 | None | - | 1 | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 5.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49952 | 188240 | 0 | None | - | 1 | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 5.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL406888 | 212625 | 0 | None | - | 1 | Bovine | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | None | None | None | CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||||
| 44294905 | 189149 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL51084 | 189149 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294465 | 187703 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 411 | 6 | 2 | 8 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ncn(C)c2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49528 | 187703 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 411 | 6 | 2 | 8 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ncn(C)c2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 127035716 | 136434 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735588 | 136434 | 0 | None | - | 1 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 16133225 | 419 | 52 | None | -14 | 4 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 172198 | 419 | 52 | None | -14 | 4 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 2504 | 419 | 52 | None | -14 | 4 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 45266664 | 419 | 52 | None | -14 | 4 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 5272 | 419 | 52 | None | -14 | 4 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| CHEMBL408403 | 419 | 52 | None | -14 | 4 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| DB11842 | 419 | 52 | None | -14 | 4 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| CHEMBL414918 | 213161 | 0 | None | - | 1 | Human | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9507744 | |||||
| 44348285 | 16432 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL123208 | 16432 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44211278 | 186630 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 480 | 9 | 2 | 8 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48799 | 186630 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 480 | 9 | 2 | 8 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44211265 | 177471 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 425 | 8 | 2 | 7 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL46391 | 177471 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 425 | 8 | 2 | 7 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 127035515 | 136455 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735769 | 136455 | 0 | None | - | 1 | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44339988 | 161007 | 0 | None | -1 | 2 | Bovine | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL411624 | 161007 | 0 | None | -1 | 2 | Bovine | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| 44211267 | 177789 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2CC(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL46433 | 177789 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2CC(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| 127036105 | 136518 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736336 | 136518 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL412717 | 213020 | 0 | None | - | 1 | Bovine | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9608669 | |||||
| 127036106 | 136368 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734949 | 136368 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44211263 | 192132 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 2 | 7 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nc(C)nc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL52036 | 192132 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 2 | 7 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nc(C)nc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 44295009 | 187171 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49207 | 187171 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294721 | 101220 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 464 | 8 | 1 | 9 | 3.9 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C#N)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL295935 | 101220 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 464 | 8 | 1 | 9 | 3.9 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C#N)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 10321186 | 15513 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| CHEMBL121705 | 15513 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| 44294518 | 188277 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(CC(=O)O)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL50007 | 188277 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(CC(=O)O)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL216678 | 209337 | 0 | None | - | 1 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C | 10.1021/jm9507744 | |||||
| 44294610 | 188145 | 0 | None | - | 1 | Rabbit | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49848 | 188145 | 0 | None | - | 1 | Rabbit | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 73346386 | 92616 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2435818 | 92616 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10048997 | 15501 | 0 | None | 14 | 2 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL121635 | 15501 | 0 | None | 14 | 2 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| 44211264 | 101810 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 8 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL300194 | 101810 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 8 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44294618 | 188394 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(OC)cccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL50174 | 188394 | 0 | None | - | 1 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(OC)cccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294637 | 163147 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 451 | 8 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL417910 | 163147 | 0 | None | - | 1 | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 451 | 8 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294822 | 101159 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL295498 | 101159 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44211277 | 187966 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49715 | 187966 | 0 | None | - | 1 | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294459 | 184108 | 0 | None | - | 1 | Rabbit | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 425 | 7 | 1 | 8 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(C)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48259 | 184108 | 0 | None | - | 1 | Rabbit | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 425 | 7 | 1 | 8 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(C)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294539 | 164875 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 8 | 4.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2oc(C)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL422050 | 164875 | 0 | None | - | 1 | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 8 | 4.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2oc(C)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL216061 | 209316 | 15 | None | 1 | 2 | Rat | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | |||||
| 16133225 | 419 | 52 | None | -1 | 4 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 172198 | 419 | 52 | None | -1 | 4 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 2504 | 419 | 52 | None | -1 | 4 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 45266664 | 419 | 52 | None | -1 | 4 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 5272 | 419 | 52 | None | -1 | 4 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL408403 | 419 | 52 | None | -1 | 4 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| DB11842 | 419 | 52 | None | -1 | 4 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.ejmech.2013.01.044 | |||||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/ml500278g | |||||
| 1056 | 3371 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| 2405 | 3371 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| 77999 | 3371 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| CHEMBL121 | 3371 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| DB00412 | 3371 | 116 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| 2583 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| 592 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| 65999 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| DB00966 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| 2583 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| 592 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| 65999 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| DB00966 | 3776 | 118 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| CHEMBL411997 | 212968 | 0 | None | - | 1 | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CCSSCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||||
| 16133225 | 419 | 52 | None | -1 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 172198 | 419 | 52 | None | -1 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 2504 | 419 | 52 | None | -1 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 45266664 | 419 | 52 | None | -1 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 5272 | 419 | 52 | None | -1 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL408403 | 419 | 52 | None | -1 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| DB11842 | 419 | 52 | None | -1 | 4 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.5b01495 | |||||
| 10390188 | 207257 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 475 | 5 | 1 | 7 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL92950 | 207257 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 475 | 5 | 1 | 7 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL1076604 | 208479 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 16133225 | 419 | 52 | None | -2 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| 172198 | 419 | 52 | None | -2 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| 2504 | 419 | 52 | None | -2 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| 45266664 | 419 | 52 | None | -2 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| 5272 | 419 | 52 | None | -2 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| CHEMBL408403 | 419 | 52 | None | -2 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| DB11842 | 419 | 52 | None | -2 | 4 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm011063a | |||||
| CHEMBL938 | 215907 | 28 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||||
| CHEMBL1076602 | 208477 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076603 | 208478 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 6918 | 1028 | 35 | None | 3 | 3 | Pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 9804984 | 1028 | 35 | None | 3 | 3 | Pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL189568 | 1028 | 35 | None | 3 | 3 | Pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 10479983 | 207330 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 473 | 4 | 1 | 7 | 4.8 | Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(-c5nnn[nH]5)cc5ccccc5c(=O)c4c3)c2n1 | 10.1021/jm00014a024 | |||
| CHEMBL93522 | 207330 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 473 | 4 | 1 | 7 | 4.8 | Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(-c5nnn[nH]5)cc5ccccc5c(=O)c4c3)c2n1 | 10.1021/jm00014a024 | |||
| 183134 | 204844 | 17 | None | - | 1 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| CHEMBL7550 | 204844 | 17 | None | - | 1 | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| 9826888 | 207877 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 6 | 1 | 8 | 4.6 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2nc(OC)ccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL96552 | 207877 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 6 | 1 | 8 | 4.6 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2nc(OC)ccc2n1 | 10.1021/jm00014a024 | |||
| 10004498 | 207279 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 461 | 5 | 1 | 6 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Cc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL93159 | 207279 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 461 | 5 | 1 | 6 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Cc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| 16133225 | 419 | 52 | None | -1 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 172198 | 419 | 52 | None | -1 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 2504 | 419 | 52 | None | -1 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 45266664 | 419 | 52 | None | -1 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 5272 | 419 | 52 | None | -1 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| CHEMBL408403 | 419 | 52 | None | -1 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| DB11842 | 419 | 52 | None | -1 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| CHEMBL1076663 | 208488 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9015747 | |||||
| 4673492 | 4138 | 9 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2013.09.004 | |||
| 8324 | 4138 | 9 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL159096 | 4138 | 9 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL1076601 | 208476 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 46880544 | 208485 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076632 | 208485 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| 132387 | 162334 | 23 | None | -9 | 3 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL416477 | 162334 | 23 | None | -9 | 3 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00070a012 | |||
| 44282952 | 120429 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 511 | 7 | 2 | 8 | 3.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL35381 | 120429 | 0 | None | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 511 | 7 | 2 | 8 | 3.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 2541 | 786 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 587 | 786 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 6907 | 786 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL1016 | 786 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| DB00796 | 786 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| DB13919 | 786 | 120 | None | 1 | 6 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 10344188 | 112648 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 459 | 5 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2ccccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL330298 | 112648 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 459 | 5 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2ccccc2n1 | 10.1021/jm00014a024 | |||
| 10079601 | 212531 | 14 | None | -4 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1021/ml500278g | |||||
| CHEMBL404594 | 212531 | 14 | None | -4 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1021/ml500278g | |||||
| 10004489 | 206754 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 461 | 4 | 1 | 7 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL90027 | 206754 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 461 | 4 | 1 | 7 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 45102750 | 63778 | 4 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801740 | 63778 | 4 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 11754146 | 159687 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 463 | 5 | 1 | 7 | 5.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL410417 | 159687 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 463 | 5 | 1 | 7 | 5.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL1076613 | 208481 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076633 | 208486 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076662 | 208487 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9015747 | |||||
| CHEMBL1076603 | 208478 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 11994289 | 82477 | 0 | None | -1 | 2 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL217673 | 82477 | 0 | None | -1 | 2 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10031067 | 100352 | 4 | None | 2 | 3 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL289614 | 100352 | 4 | None | 2 | 3 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 127030943 | 139195 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787243 | 139195 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787375 | 139195 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787700 | 139195 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 132387 | 162334 | 23 | None | -12 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL416477 | 162334 | 23 | None | -12 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| 87219032 | 175975 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4588688 | 175975 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 9891811 | 119742 | 1 | None | 8128 | 2 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL347703 | 119742 | 1 | None | 8128 | 2 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL4524047 | 119742 | 1 | None | 8128 | 2 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 10257882 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| 8448 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| CHEMBL539423 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| DB12548 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| 1481 | 2066 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 3749 | 2066 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 589 | 2066 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 6908 | 2066 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| CHEMBL1513 | 2066 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| DB01029 | 2066 | 116 | None | -1 | 3 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| CHEMBL1076612 | 208480 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C(=O)c2ccccc2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 46880544 | 208485 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| CHEMBL1076632 | 208485 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 10257882 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| 8448 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| CHEMBL539423 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| DB12548 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| 14956739 | 206302 | 0 | None | - | 1 | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL87074 | 206302 | 0 | None | - | 1 | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 3047757 | 167458 | 23 | None | - | 1 | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 554 | 10 | 1 | 9 | 5.2 | CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL429847 | 167458 | 23 | None | - | 1 | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 554 | 10 | 1 | 9 | 5.2 | CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm9504722 | |||
| 16133225 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 172198 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 2504 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 45266664 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| 5272 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| CHEMBL408403 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| DB11842 | 419 | 52 | None | -1 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9015747 | |||||
| CHEMBL1076633 | 208486 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)O | 10.1021/jm9015747 | |||||
| 16133225 | 419 | 52 | None | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 172198 | 419 | 52 | None | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 2504 | 419 | 52 | None | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 45266664 | 419 | 52 | None | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 5272 | 419 | 52 | None | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| CHEMBL408403 | 419 | 52 | None | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| DB11842 | 419 | 52 | None | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | |||||
| 10322229 | 121508 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL358335 | 121508 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10410148 | 205130 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 425 | 6 | 2 | 8 | 3.4 | CCCc1nc(C)n2nc(N)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL77959 | 205130 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 425 | 6 | 2 | 8 | 3.4 | CCCc1nc(C)n2nc(N)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 25141239 | 183866 | 0 | None | - | 1 | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 528 | 11 | 2 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NCc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480906 | 183866 | 0 | None | - | 1 | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 528 | 11 | 2 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NCc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10322229 | 121508 | 0 | None | -1 | 2 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL358335 | 121508 | 0 | None | -1 | 2 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00103a014 | |||
| 10366402 | 206840 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 448 | 5 | 2 | 8 | 3.8 | CCc1cc(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)n2nccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL90513 | 206840 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 448 | 5 | 2 | 8 | 3.8 | CCc1cc(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)n2nccc2n1 | 10.1021/jm00014a024 | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 3936 | 2210 | 35 | None | 1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 6603900 | 2210 | 35 | None | 1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL288174 | 2210 | 35 | None | 1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 3936 | 2210 | 35 | None | -1 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 6603900 | 2210 | 35 | None | -1 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL288174 | 2210 | 35 | None | -1 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL5274111 | 193795 | 0 | None | 1 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1060 | 30 | 14 | 13 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | |||
| 10006413 | 37485 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 506 | 9 | 1 | 7 | 5.7 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL145564 | 37485 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 506 | 9 | 1 | 7 | 5.7 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00103a014 | |||
| 14956757 | 67593 | 0 | None | - | 1 | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL19018 | 67593 | 0 | None | - | 1 | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 45102601 | 169571 | 12 | None | 1995 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4435800 | 169571 | 12 | None | 1995 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 87218373 | 170245 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4445778 | 170245 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218514 | 176086 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4591218 | 176086 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10050044 | 111528 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| CHEMBL327903 | 111528 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| CHEMBL1076604 | 208479 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 145957897 | 162072 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 984 | 28 | 14 | 13 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL4160691 | 162072 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 984 | 28 | 14 | 13 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 44320012 | 167923 | 0 | None | - | 1 | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL431411 | 167923 | 0 | None | - | 1 | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 10603443 | 34812 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 587 | 13 | 3 | 8 | 5.6 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2N=[N+]=[N-])cc1 | 10.1021/jm991050l | |||
| CHEMBL143118 | 34812 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 587 | 13 | 3 | 8 | 5.6 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2N=[N+]=[N-])cc1 | 10.1021/jm991050l | |||
| 9939191 | 98946 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL279629 | 98946 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL97539 | 98946 | 1 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10079766 | 96982 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1045 | 22 | 13 | 14 | -2.0 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C/CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||
| CHEMBL266450 | 96982 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1045 | 22 | 13 | 14 | -2.0 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C/CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||
| 10011335 | 161268 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1045 | 22 | 13 | 14 | -2.0 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C\CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||
| CHEMBL412045 | 161268 | 0 | None | - | 1 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1045 | 22 | 13 | 14 | -2.0 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H]1CS/C=C\CC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm011063a | |||
| 192314 | 114500 | 28 | None | -15 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL1237157 | 114500 | 28 | None | -15 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL333534 | 114500 | 28 | None | -15 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00070a012 | |||
| 72168 | 102687 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 554 | 8 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3-c3nnn[nH]3)c(Br)c2c1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL304639 | 102687 | 24 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 554 | 8 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3-c3nnn[nH]3)c(Br)c2c1 | 10.1016/j.bmc.2010.10.043 | |||
| 10393016 | 206936 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 5 | 4.9 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL91113 | 206936 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 5 | 4.9 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 9895957 | 10673 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL11706 | 10673 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1016/j.bmc.2012.06.011 | |||
| 9895957 | 10673 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| CHEMBL11706 | 10673 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| 155514738 | 169909 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 656 | 15 | 4 | 8 | 5.3 | CCCCc1nc(Cl)c(CNC(=O)CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4440944 | 169909 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 656 | 15 | 4 | 8 | 5.3 | CCCCc1nc(Cl)c(CNC(=O)CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 71465043 | 171976 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 565 | 13 | 3 | 7 | 6.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4470834 | 171976 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 565 | 13 | 3 | 7 | 6.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10409294 | 105391 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 3.8 | CCCc1nc(C)n2cnnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL311657 | 105391 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 3.8 | CCCc1nc(C)n2cnnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10410197 | 163340 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL419089 | 163340 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 9933044 | 168021 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.1 | CCCc1nc(C)n2nc(S)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL432153 | 168021 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.1 | CCCc1nc(C)n2nc(S)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10411083 | 205040 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 442 | 7 | 3 | 9 | 2.7 | CCCc1nc(CO)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL77036 | 205040 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 442 | 7 | 3 | 9 | 2.7 | CCCc1nc(CO)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 53319274 | 57600 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668000 | 57600 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| 9895957 | 10673 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm058225d | |||
| CHEMBL11706 | 10673 | 18 | None | -5 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm058225d | |||
| 2541 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 587 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 6907 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL1016 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| DB00796 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| DB13919 | 786 | 120 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 44567746 | 191416 | 0 | None | - | 1 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL519274 | 191416 | 0 | None | - | 1 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL5271484 | 193686 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 315 | 3 | 1 | 4 | 2.8 | CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 44567782 | 183724 | 0 | None | - | 1 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 521 | 10 | 2 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)Nc2nccs2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480341 | 183724 | 0 | None | - | 1 | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 521 | 10 | 2 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)Nc2nccs2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 87218444 | 171448 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4463203 | 171448 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 6918 | 1028 | 35 | None | -25118 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| 9804984 | 1028 | 35 | None | -25118 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| CHEMBL189568 | 1028 | 35 | None | -25118 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| 19029492 | 118074 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(F)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340518 | 118074 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(F)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 44567709 | 190659 | 0 | None | - | 1 | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 438 | 9 | 2 | 6 | 3.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(N)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL518157 | 190659 | 0 | None | - | 1 | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 438 | 9 | 2 | 6 | 3.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(N)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10027078 | 205204 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 456 | 7 | 2 | 8 | 4.5 | CCCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78532 | 205204 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 456 | 7 | 2 | 8 | 4.5 | CCCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL5272962 | 193741 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.7 | O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 10074277 | 205370 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 489 | 7 | 2 | 9 | 2.5 | CCCc1nc(C)n2nc(S(N)(=O)=O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL79879 | 205370 | 0 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 489 | 7 | 2 | 9 | 2.5 | CCCc1nc(C)n2nc(S(N)(=O)=O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10343950 | 205195 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 454 | 8 | 1 | 8 | 4.0 | CCCc1nc(COC)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78433 | 205195 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 454 | 8 | 1 | 8 | 4.0 | CCCc1nc(COC)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 11754586 | 107090 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 7 | 1 | 7 | 4.6 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL315881 | 107090 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 7 | 1 | 7 | 4.6 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 10001600 | 104106 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 3.8 | CCCc1nc(C)n2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL309384 | 104106 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 3.8 | CCCc1nc(C)n2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10391688 | 105733 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 512 | 9 | 1 | 10 | 3.2 | CCCc1nc(C)n2c(=O)n(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL312632 | 105733 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 512 | 9 | 1 | 10 | 3.2 | CCCc1nc(C)n2c(=O)n(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 9956392 | 101018 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 463 | 6 | 2 | 6 | 5.8 | Cc1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL294500 | 101018 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 463 | 6 | 2 | 6 | 5.8 | Cc1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 | 10.1016/S0960-894X(01)81146-X | |||
| 5311345 | 3021 | 46 | None | -10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 597 | 3021 | 46 | None | -10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL321820 | 3021 | 46 | None | -10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 9978737 | 118892 | 1 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111971 | 118892 | 1 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL342261 | 118892 | 1 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL1076630 | 208483 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 168289415 | 191314 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 8 | 1 | 9 | 4.8 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5191326 | 191314 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 8 | 1 | 9 | 4.8 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| 23298215 | 168076 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 493 | 7 | 3 | 7 | 5.1 | O=C(O)c1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL432529 | 168076 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 493 | 7 | 3 | 7 | 5.1 | O=C(O)c1cccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c12 | 10.1016/S0960-894X(01)81146-X | |||
| 44567849 | 189222 | 0 | None | - | 1 | Pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL511490 | 189222 | 0 | None | - | 1 | Pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10048997 | 15501 | 0 | None | -14 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL121635 | 15501 | 0 | None | -14 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| 155520317 | 170489 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4449166 | 170489 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155523092 | 170814 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.1 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4453362 | 170814 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.1 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87219128 | 172888 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 14 | 3 | 5 | 6.6 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4515703 | 172888 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 14 | 3 | 5 | 6.6 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218933 | 175082 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 555 | 14 | 3 | 5 | 6.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4568554 | 175082 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 555 | 14 | 3 | 5 | 6.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10049001 | 205429 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.1 | CCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80219 | 205429 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.1 | CCCc1nc(C)n2c(S)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10697700 | 206901 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 539 | 11 | 1 | 5 | 4.8 | CCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)C(=O)N2CCCC)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90872 | 206901 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 539 | 11 | 1 | 5 | 4.8 | CCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)C(=O)N2CCCC)cc1 | 10.1021/jm9904147 | |||
| 44284308 | 14776 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 617 | 12 | 1 | 10 | 6.4 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1206594 | 14776 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 617 | 12 | 1 | 10 | 6.4 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079769 | 14776 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 617 | 12 | 1 | 10 | 6.4 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL4299329 | 213614 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||||
| CHEMBL4302429 | 213614 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||||
| 45488134 | 196977 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 8 | 1 | 7 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL566614 | 196977 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 8 | 1 | 7 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 23298206 | 100754 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 463 | 6 | 2 | 6 | 5.8 | Cc1cccc2c(C(=O)O)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C3CC3)nc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL292792 | 100754 | 0 | None | - | 1 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 463 | 6 | 2 | 6 | 5.8 | Cc1cccc2c(C(=O)O)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C3CC3)nc12 | 10.1016/S0960-894X(01)81146-X | |||
| 19029534 | 18563 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(F)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127605 | 18563 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(F)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10458763 | 204938 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 503 | 8 | 2 | 9 | 2.7 | CCCc1nc(C)n2nc(S(=O)(=O)NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76359 | 204938 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 503 | 8 | 2 | 9 | 2.7 | CCCc1nc(C)n2nc(S(=O)(=O)NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10095683 | 121512 | 0 | None | -1 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL358359 | 121512 | 0 | None | -1 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 10095683 | 121512 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL358359 | 121512 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| 15480220 | 200734 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 467 | 6 | 2 | 6 | 5.6 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccc(F)cc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL60010 | 200734 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 467 | 6 | 2 | 6 | 5.6 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccc(F)cc12 | 10.1016/S0960-894X(01)81146-X | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 44254496 | 5625 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 770 | 18 | 7 | 8 | 2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm900651p | |||
| CHEMBL1077582 | 5625 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 770 | 18 | 7 | 8 | 2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm900651p | |||
| 19029594 | 18099 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc([N+](=O)[O-])cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL126801 | 18099 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc([N+](=O)[O-])cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 19029638 | 164211 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc([N+](=O)[O-])c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL421092 | 164211 | 0 | None | - | 1 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc([N+](=O)[O-])c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10052744 | 14811 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 530 | 10 | 1 | 5 | 7.2 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(c2ccccc2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1207064 | 14811 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 530 | 10 | 1 | 5 | 7.2 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(c2ccccc2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL343622 | 14811 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 530 | 10 | 1 | 5 | 7.2 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(c2ccccc2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 44567819 | 183915 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481294 | 183915 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10005278 | 205190 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 478 | 6 | 1 | 7 | 4.8 | CCCc1nc(C)n2nc(C(F)(F)F)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78399 | 205190 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 478 | 6 | 1 | 7 | 4.8 | CCCc1nc(C)n2nc(C(F)(F)F)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10049622 | 104142 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 454 | 8 | 1 | 8 | 4.0 | CCCc1nc(C)n2nc(COC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL309458 | 104142 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 454 | 8 | 1 | 8 | 4.0 | CCCc1nc(C)n2nc(COC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 19029579 | 18504 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.1 | O=C(/N=c1\sc(C2CC2)nn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ccccc1Cl | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127332 | 18504 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.1 | O=C(/N=c1\sc(C2CC2)nn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ccccc1Cl | 10.1016/S0960-894X(97)00026-7 | |||
| 10094936 | 16836 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL1237156 | 16836 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL124772 | 16836 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| 10094936 | 16836 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL1237156 | 16836 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL124772 | 16836 | 0 | None | -9 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 44475015 | 171524 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4464191 | 171524 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155557693 | 174668 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 599 | 13 | 3 | 7 | 6.2 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4558883 | 174668 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 599 | 13 | 3 | 7 | 6.2 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10003793 | 14684 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 9 | 1 | 6 | 4.5 | CCCCc1nc(C)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1205758 | 14684 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 9 | 1 | 6 | 4.5 | CCCCc1nc(C)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL145276 | 14684 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 9 | 1 | 6 | 4.5 | CCCCc1nc(C)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 10504330 | 206814 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 4.4 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)N(c2ccccc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| CHEMBL90411 | 206814 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 4.4 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)N(c2ccccc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| 155535176 | 172030 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc3ccccc3c2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4471668 | 172030 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc3ccccc3c2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 46935636 | 102572 | 0 | None | -31622 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL2440460 | 102572 | 0 | None | -31622 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL3040772 | 102572 | 0 | None | -31622 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL5271135 | 193671 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 4.6 | Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 10391609 | 14682 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 510 | 10 | 1 | 6 | 5.8 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1205753 | 14682 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 510 | 10 | 1 | 6 | 5.8 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL144952 | 14682 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 510 | 10 | 1 | 6 | 5.8 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 45488167 | 197154 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 520 | 10 | 1 | 8 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL567898 | 197154 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 520 | 10 | 1 | 8 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 44567850 | 183963 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481664 | 183963 | 0 | None | - | 1 | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 19029509 | 18068 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 5 | 1 | 7 | 4.5 | Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL126643 | 18068 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 5 | 1 | 7 | 4.5 | Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 123794 | 893 | 46 | None | -67608 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b01780 | |||||
| 3944 | 893 | 46 | None | -67608 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b01780 | |||||
| 594 | 893 | 46 | None | -67608 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b01780 | |||||
| CHEMBL1885579 | 893 | 46 | None | -67608 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.9b01780 | |||||
| 10004228 | 205015 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 456 | 7 | 1 | 8 | 4.5 | CCCc1nc(C)n2nc(SC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76866 | 205015 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 456 | 7 | 1 | 8 | 4.5 | CCCc1nc(C)n2nc(SC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10005644 | 205520 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 486 | 7 | 1 | 7 | 5.5 | CCCc1nc(C)n2nc(-c3ccccc3)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80854 | 205520 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 486 | 7 | 1 | 7 | 5.5 | CCCc1nc(C)n2nc(-c3ccccc3)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL1076601 | 208476 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 168294859 | 192276 | 0 | None | -19 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5205769 | 192276 | 0 | None | -19 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10029566 | 205077 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 517 | 8 | 1 | 9 | 3.1 | CCCc1nc(C)n2nc(S(=O)(=O)N(C)C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL77384 | 205077 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 517 | 8 | 1 | 9 | 3.1 | CCCc1nc(C)n2nc(S(=O)(=O)N(C)C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 59984617 | 85277 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 558 | 8 | 2 | 6 | 7.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)O)cc2C(=O)O)cc1 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL2260199 | 85277 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 558 | 8 | 2 | 6 | 7.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)O)cc2C(=O)O)cc1 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL1076612 | 208480 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C(=O)c2ccccc2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 87218987 | 171007 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.6 | CCCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4456519 | 171007 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.6 | CCCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10415026 | 165673 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 544 | 10 | 1 | 5 | 7.5 | CCCCC1=NC(c2ccc(Cl)cc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL424483 | 165673 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 544 | 10 | 1 | 5 | 7.5 | CCCCC1=NC(c2ccc(Cl)cc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 19029491 | 116964 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Cl)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL338670 | 116964 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Cl)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10365342 | 113495 | 0 | None | -16 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| CHEMBL331983 | 113495 | 0 | None | -16 | 2 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| 155516694 | 170113 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 507 | 12 | 3 | 5 | 5.9 | CCCCc1nc(C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4443691 | 170113 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 507 | 12 | 3 | 5 | 5.9 | CCCCc1nc(C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 19029483 | 18828 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.6 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL128003 | 18828 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.6 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10790260 | 206777 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)Nc2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90187 | 206777 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)Nc2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 135723840 | 139142 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787059 | 139142 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 3936 | 2210 | 35 | None | -1 | 4 | Pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 6603900 | 2210 | 35 | None | -1 | 4 | Pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL288174 | 2210 | 35 | None | -1 | 4 | Pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 44350610 | 118166 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 525 | 8 | 2 | 8 | 4.2 | CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340863 | 118166 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 525 | 8 | 2 | 8 | 4.2 | CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10005741 | 111450 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 488 | 7 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL327535 | 111450 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 488 | 7 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 10031067 | 100352 | 4 | None | -2 | 3 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL289614 | 100352 | 4 | None | -2 | 3 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 127029976 | 139217 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3786145 | 139217 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787767 | 139217 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 23298214 | 102012 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 450 | 6 | 2 | 7 | 4.8 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cccnc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL301689 | 102012 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 450 | 6 | 2 | 7 | 4.8 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cccnc12 | 10.1016/S0960-894X(01)81146-X | |||
| 19029671 | 118087 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2OC)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340618 | 118087 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2OC)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10745817 | 119375 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111973 | 119375 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL344464 | 119375 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| 87219174 | 169765 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 14 | 3 | 6 | 5.9 | CCCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4438878 | 169765 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 14 | 3 | 6 | 5.9 | CCCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 44567745 | 183885 | 0 | None | - | 1 | Pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 480 | 10 | 2 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481089 | 183885 | 0 | None | - | 1 | Pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 480 | 10 | 2 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44350616 | 18827 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 6 | 2 | 8 | 3.6 | Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127988 | 18827 | 0 | None | - | 1 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 497 | 6 | 2 | 8 | 3.6 | Cc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10345537 | 111602 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.0 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL328296 | 111602 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.0 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 10481196 | 112746 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 7 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2cc(C(=O)O)ccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL330508 | 112746 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 7 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2cc(C(=O)O)ccc2n1 | 10.1021/jm00014a024 | |||
| 10432780 | 164512 | 0 | None | -10 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL421473 | 164512 | 0 | None | -10 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| 10432780 | 164512 | 0 | None | -10 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL421473 | 164512 | 0 | None | -10 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 127029977 | 139218 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3786986 | 139218 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787768 | 139218 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 44325313 | 207440 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.3 | CCOC(=O)c1c(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| CHEMBL94106 | 207440 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.3 | CCOC(=O)c1c(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| 127866 | 102805 | 17 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 449 | 6 | 2 | 6 | 5.5 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL305365 | 102805 | 17 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 449 | 6 | 2 | 6 | 5.5 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 | 10.1016/S0960-894X(01)81146-X | |||
| 127866 | 102805 | 17 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 449 | 6 | 2 | 6 | 5.5 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 | 10.1016/S0960-894X(01)81147-1 | |||
| CHEMBL305365 | 102805 | 17 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 449 | 6 | 2 | 6 | 5.5 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ccccc12 | 10.1016/S0960-894X(01)81147-1 | |||
| 132404 | 119786 | 14 | None | 36 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | |||
| CHEMBL348126 | 119786 | 14 | None | 36 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | |||
| 15658054 | 206726 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 429 | 8 | 2 | 8 | 3.7 | CCOC(=O)c1cnc(CC)nc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| CHEMBL89877 | 206726 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 429 | 8 | 2 | 8 | 3.7 | CCOC(=O)c1cnc(CC)nc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| CHEMBL5273768 | 193776 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 5.0 | O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5271903 | 193702 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 4.4 | CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 | 10.1016/j.bmcl.2023.129349 | |||
| 19029687 | 19373 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.2 | CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL129181 | 19373 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.2 | CCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 11744384 | 32347 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL141065 | 32347 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL2111972 | 32347 | 0 | None | - | 1 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| 45488164 | 197831 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 602 | 12 | 1 | 7 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1 | 10.1021/jm901272d | |||
| CHEMBL572276 | 197831 | 0 | None | - | 1 | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 602 | 12 | 1 | 7 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1 | 10.1021/jm901272d | |||
| 118719137 | 115445 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1405 | 38 | 7 | 16 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCC[C@H](NC(=O)Cc4csc(=N)n4C)C(=O)N[C@@H](Cc4cn(Cc5ccccc5)c[n+]4C)C(=O)NC4CCN(C)CC4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm401789v | |||
| CHEMBL3234445 | 115445 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1405 | 38 | 7 | 16 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCC[C@H](NC(=O)Cc4csc(=N)n4C)C(=O)N[C@@H](Cc4cn(Cc5ccccc5)c[n+]4C)C(=O)NC4CCN(C)CC4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm401789v | |||
| CHEMBL3350781 | 115445 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1405 | 38 | 7 | 16 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCC[C@H](NC(=O)Cc4csc(=N)n4C)C(=O)N[C@@H](Cc4cn(Cc5ccccc5)c[n+]4C)C(=O)NC4CCN(C)CC4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm401789v | |||
| 10252692 | 205184 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.8 | CCCc1nc(CC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78342 | 205184 | 0 | None | - | 1 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.8 | CCCc1nc(CC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10050933 | 205500 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 4.0 | CCCc1nc(C)n2nc(C(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80688 | 205500 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 4.0 | CCCc1nc(C)n2nc(C(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL5282200 | 194149 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 345 | 4 | 2 | 5 | 2.4 | Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 132840 | 105489 | 22 | None | 1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL312104 | 105489 | 22 | None | 1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 132840 | 105489 | 22 | None | -1 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL312104 | 105489 | 22 | None | -1 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL5277518 | 193936 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 5 | 2.9 | CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL1076602 | 208477 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 145957579 | 162311 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 497 | 7 | 0 | 3 | 7.0 | CCCCC1=N/C(=C\c2ccc(Br)cc2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL4164514 | 162311 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 497 | 7 | 0 | 3 | 7.0 | CCCCC1=N/C(=C\c2ccc(Br)cc2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| 5249743 | 107025 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL315444 | 107025 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9904147 | |||
| 10674630 | 206832 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 10 | 1 | 5 | 5.3 | CCCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90483 | 206832 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 10 | 1 | 5 | 5.3 | CCCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 11577472 | 14612 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 503 | 9 | 1 | 8 | 5.2 | CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204970 | 14612 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 503 | 9 | 1 | 8 | 5.2 | CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2021416 | 14612 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 503 | 9 | 1 | 8 | 5.2 | CCCCc1nc(Cl)c(C(=O)OCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 5249743 | 107025 | 1 | None | -1 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL315444 | 107025 | 1 | None | -1 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 53317942 | 57598 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1667999 | 57598 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm011063a | |||
| 5249743 | 107025 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL315444 | 107025 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| 87218826 | 172097 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 13 | 3 | 5 | 7.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4472489 | 172097 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 13 | 3 | 5 | 7.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 45488163 | 197767 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 630 | 13 | 0 | 8 | 7.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1 | 10.1021/jm901272d | |||
| CHEMBL571763 | 197767 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 630 | 13 | 0 | 8 | 7.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1 | 10.1021/jm901272d | |||
| 163409136 | 190902 | 3 | None | 18 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5185088 | 190902 | 3 | None | 18 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5289070 | 194456 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 269 | 3 | 2 | 5 | 0.6 | CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL1076613 | 208481 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 10433378 | 204917 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.3 | CCCc1nc(CO)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76149 | 204917 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.3 | CCCc1nc(CO)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10071944 | 205017 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 1 | 8 | 3.8 | CCCc1nc(C)n2nc(OC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76900 | 205017 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 440 | 7 | 1 | 8 | 3.8 | CCCc1nc(C)n2nc(OC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL5275739 | 193870 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.2 | CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 19029650 | 20240 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(OC)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL130530 | 20240 | 0 | None | - | 1 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(OC)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 168295859 | 192285 | 0 | None | 50 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5205969 | 192285 | 0 | None | 50 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5287876 | 194399 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 5 | 1 | 4 | 2.5 | CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2023.129349 | |||
| 45488125 | 197153 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 360 | 7 | 1 | 5 | 3.6 | CCCc1nc2c(C)cccc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL567897 | 197153 | 0 | None | - | 1 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 360 | 7 | 1 | 5 | 3.6 | CCCc1nc2c(C)cccc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 10742620 | 57602 | 0 | None | 16 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668003 | 57602 | 0 | None | 16 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 131590 | 20703 | 44 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL130896 | 20703 | 44 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| 131590 | 20703 | 44 | None | -1 | 3 | Rabbit | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL130896 | 20703 | 44 | None | -1 | 3 | Rabbit | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00052a006 | |||
| 44567851 | 183805 | 0 | None | - | 1 | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1cc(Cc2ccccc2)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480506 | 183805 | 0 | None | - | 1 | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1cc(Cc2ccccc2)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 19029656 | 118467 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Br)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL341292 | 118467 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(Br)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 2806 | 3969 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 3937 | 3969 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 593 | 3969 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 60846 | 3969 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL1069 | 3969 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| DB00177 | 3969 | 110 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 25141238 | 192545 | 0 | None | - | 1 | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 494 | 11 | 1 | 6 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL521093 | 192545 | 0 | None | - | 1 | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 494 | 11 | 1 | 6 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 127031545 | 139196 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787379 | 139196 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787701 | 139196 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 192314 | 114500 | 28 | None | -26 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL1237157 | 114500 | 28 | None | -26 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL333534 | 114500 | 28 | None | -26 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| 136093942 | 139094 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3786570 | 139094 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44567817 | 183039 | 0 | None | - | 1 | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 506 | 9 | 1 | 6 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL479399 | 183039 | 0 | None | - | 1 | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 506 | 9 | 1 | 6 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 23298216 | 163179 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 5 | 2 | 6 | 4.9 | Cc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL418122 | 163179 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 5 | 2 | 6 | 4.9 | Cc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| 19029654 | 18343 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2[N+](=O)[O-])s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127090 | 18343 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 512 | 7 | 1 | 9 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2[N+](=O)[O-])s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10141821 | 100058 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL287116 | 100058 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Cl)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 9804423 | 202724 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 451 | 7 | 2 | 6 | 5.5 | CCCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL61814 | 202724 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 451 | 7 | 2 | 6 | 5.5 | CCCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| 19029618 | 117855 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Br)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340304 | 117855 | 0 | None | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2Br)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 2541 | 786 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 587 | 786 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 6907 | 786 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1016 | 786 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB00796 | 786 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| DB13919 | 786 | 120 | None | -1 | 6 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00041a016 | |||
| CHEMBL1076631 | 208484 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 44350472 | 18309 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 593 | 6 | 1 | 7 | 4.7 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2I)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127068 | 18309 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 593 | 6 | 1 | 7 | 4.7 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2I)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10096683 | 207089 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.4 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL91928 | 207089 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.4 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| 3936 | 2210 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 6603900 | 2210 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL288174 | 2210 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 3936 | 2210 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 6603900 | 2210 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL288174 | 2210 | 35 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 44284325 | 14774 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 603 | 12 | 1 | 10 | 6.1 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)CC)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1206585 | 14774 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 603 | 12 | 1 | 10 | 6.1 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)CC)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079768 | 14774 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 603 | 12 | 1 | 10 | 6.1 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)CC)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 10348632 | 205428 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.9 | CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80218 | 205428 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.9 | CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 11672486 | 98511 | 0 | None | -3 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 994 | 25 | 12 | 12 | 0.3 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| CHEMBL276163 | 98511 | 0 | None | -3 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 994 | 25 | 12 | 12 | 0.3 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | |||
| CHEMBL5283862 | 194231 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 3 | 2 | 4 | 2.5 | O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5276125 | 193884 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 385 | 6 | 1 | 4 | 4.7 | O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 44567781 | 183722 | 0 | None | - | 1 | Pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 11 | 1 | 6 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480340 | 183722 | 0 | None | - | 1 | Pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 11 | 1 | 6 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL1076664 | 208489 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 155526996 | 171140 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 549 | 14 | 3 | 5 | 6.8 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4458466 | 171140 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 549 | 14 | 3 | 5 | 6.8 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218835 | 171184 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 539 | 13 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4459070 | 171184 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 539 | 13 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155552503 | 174170 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 533 | 13 | 3 | 5 | 6.5 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4547120 | 174170 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 533 | 13 | 3 | 5 | 6.5 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10764613 | 206907 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 4.5 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90887 | 206907 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 4.5 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 145952582 | 162977 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 782 | 12 | 0 | 6 | 10.6 | CCCCC1=N/C(=C\c2ccccc2Br)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL4175147 | 162977 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 782 | 12 | 0 | 6 | 10.6 | CCCCC1=N/C(=C\c2ccccc2Br)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| 19029482 | 117051 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Br)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL339120 | 117051 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 6 | 1 | 7 | 4.9 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Br)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10507383 | 106105 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 5.6 | CCCCN1C(=O)C(C)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL313392 | 106105 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 5.6 | CCCCN1C(=O)C(C)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 11801362 | 107087 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 580 | 9 | 2 | 5 | 5.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC2CCCCC2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL315873 | 107087 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 580 | 9 | 2 | 5 | 5.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC2CCCCC2)cc1 | 10.1021/jm9904147 | |||
| 10025379 | 205289 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 4.1 | CCCc1nc(C)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL79171 | 205289 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 4.1 | CCCc1nc(C)n2nc(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10324104 | 205535 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 511 | 10 | 2 | 10 | 3.8 | CCCc1nc(C)n2nc(NCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80967 | 205535 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 511 | 10 | 2 | 10 | 3.8 | CCCc1nc(C)n2nc(NCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 9914750 | 203252 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 483 | 6 | 2 | 6 | 6.1 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cc(Cl)ccc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL64567 | 203252 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 483 | 6 | 2 | 6 | 6.1 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2cc(Cl)ccc12 | 10.1016/S0960-894X(01)81146-X | |||
| 19029652 | 118096 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Cl)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL340662 | 118096 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 501 | 6 | 1 | 7 | 4.8 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(Cl)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 23298208 | 203164 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 479 | 7 | 2 | 7 | 5.5 | COc1ccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c2c1 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL64220 | 203164 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 479 | 7 | 2 | 7 | 5.5 | COc1ccc2nc(C3CC3)c(Oc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(C(=O)O)c2c1 | 10.1016/S0960-894X(01)81146-X | |||
| 10765881 | 206906 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 448 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90885 | 206906 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 448 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 44567818 | 183886 | 0 | None | - | 1 | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 4.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCOCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481106 | 183886 | 0 | None | - | 1 | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 4.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCOCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10321731 | 163447 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 7 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(C(=O)O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL419835 | 163447 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 454 | 7 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(C(=O)O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10251107 | 205006 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 412 | 5 | 2 | 8 | 3.1 | CCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76787 | 205006 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 412 | 5 | 2 | 8 | 3.1 | CCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 44350526 | 18207 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127002 | 18207 | 0 | None | - | 1 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 19029576 | 99973 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL286537 | 99973 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 7 | 4.1 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 44567744 | 183884 | 0 | None | - | 1 | Pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481088 | 183884 | 0 | None | - | 1 | Pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 18950393 | 168177 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1ncc(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL433230 | 168177 | 0 | None | - | 1 | Rat | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1ncc(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 44312565 | 204771 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| CHEMBL74767 | 204771 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| 9872676 | 78195 | 0 | None | -9332 | 16 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | |||
| CHEMBL210514 | 78195 | 0 | None | -9332 | 16 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | |||
| 10790818 | 206921 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 5 | 4.7 | Cc1ccc(N2C(=O)C3(CCCC3)C(=O)N2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90999 | 206921 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 5 | 4.7 | Cc1ccc(N2C(=O)C3(CCCC3)C(=O)N2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1021/jm9904147 | |||
| 44283775 | 14779 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 591 | 9 | 1 | 8 | 6.8 | CCCCc1nc(Cl)c(C(=O)Oc2ccc3c(c2)CCC3)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1206631 | 14779 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 591 | 9 | 1 | 8 | 6.8 | CCCCc1nc(Cl)c(C(=O)Oc2ccc3c(c2)CCC3)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079770 | 14779 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 591 | 9 | 1 | 8 | 6.8 | CCCCc1nc(Cl)c(C(=O)Oc2ccc3c(c2)CCC3)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 87218678 | 170335 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4447138 | 170335 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 75031588 | 173708 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4535903 | 173708 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 168274602 | 190376 | 0 | None | -97 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5177359 | 190376 | 0 | None | -97 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10695405 | 206520 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL88471 | 206520 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 155522135 | 170655 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 651 | 14 | 3 | 5 | 8.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4451425 | 170655 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 651 | 14 | 3 | 5 | 8.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218371 | 173671 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2cccc3ccccc23)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4534876 | 173671 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2cccc3ccccc23)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10095241 | 111470 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 4.7 | Cc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| CHEMBL327633 | 111470 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 4.7 | Cc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| 10028164 | 112576 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 481 | 6 | 1 | 8 | 4.3 | CCOC(=O)c1c(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| CHEMBL330109 | 112576 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 481 | 6 | 1 | 8 | 4.3 | CCOC(=O)c1c(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| 135723852 | 139140 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787050 | 139140 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44284107 | 14611 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 561 | 10 | 1 | 10 | 5.1 | CCCCc1nc(Cl)c(C(=O)OC(C)OC(C)=O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204966 | 14611 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 561 | 10 | 1 | 10 | 5.1 | CCCCc1nc(Cl)c(C(=O)OC(C)OC(C)=O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079784 | 14611 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 561 | 10 | 1 | 10 | 5.1 | CCCCc1nc(Cl)c(C(=O)OC(C)OC(C)=O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 23298211 | 163210 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 450 | 6 | 2 | 7 | 4.8 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ncccc12 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL418306 | 163210 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 450 | 6 | 2 | 7 | 4.8 | O=C(O)c1c(Oc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C2CC2)nc2ncccc12 | 10.1016/S0960-894X(01)81146-X | |||
| 11813485 | 18089 | 0 | None | 8 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 534 | 9 | 1 | 6 | 6.0 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm020138n | |||
| CHEMBL126755 | 18089 | 0 | None | 8 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 534 | 9 | 1 | 6 | 6.0 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1021/jm020138n | |||
| 10697829 | 207138 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 545 | 8 | 1 | 5 | 4.5 | CCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL92225 | 207138 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 545 | 8 | 1 | 5 | 4.5 | CCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 168290795 | 191947 | 0 | None | -33 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5200734 | 191947 | 0 | None | -33 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10790819 | 111462 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 6 | 1 | 5 | 4.4 | O=C1N(Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| CHEMBL327594 | 111462 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 6 | 1 | 5 | 4.4 | O=C1N(Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| 44567852 | 183806 | 0 | None | - | 1 | Pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 432 | 9 | 1 | 5 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480507 | 183806 | 0 | None | - | 1 | Pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 432 | 9 | 1 | 5 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 123814 | 421 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm701490g | |||||
| 5368 | 421 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm701490g | |||||
| CHEMBL261120 | 421 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm701490g | |||||
| 123814 | 421 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm900651p | |||||
| 5368 | 421 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm900651p | |||||
| CHEMBL261120 | 421 | 30 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm900651p | |||||
| 10480349 | 205418 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 481 | 7 | 3 | 8 | 3.2 | CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(NC(=O)c2ccccc2S(=O)(=O)O)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80167 | 205418 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 481 | 7 | 3 | 8 | 3.2 | CCCc1nc(C)n2c(O)nnc2c1Cc1ccc(NC(=O)c2ccccc2S(=O)(=O)O)cc1 | 10.1021/jm00041a016 | |||
| 10050326 | 119203 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 468 | 9 | 1 | 5 | 5.9 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL343251 | 119203 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 468 | 9 | 1 | 5 | 5.9 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 168279676 | 191129 | 0 | None | -11 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5188126 | 191129 | 0 | None | -11 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10744859 | 206591 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 533 | 9 | 1 | 5 | 4.4 | CCCCN1C(=O)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL88924 | 206591 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 533 | 9 | 1 | 5 | 4.4 | CCCCN1C(=O)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 44350541 | 118445 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C(F)(F)F)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL341109 | 118445 | 0 | None | - | 1 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C(F)(F)F)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10053872 | 163477 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 6 | 2 | 8 | 3.2 | CCCc1ncn2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL420028 | 163477 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 412 | 6 | 2 | 8 | 3.2 | CCCc1ncn2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 168287840 | 191306 | 0 | None | -32 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5191241 | 191306 | 0 | None | -32 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 19029545 | 18015 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL126351 | 18015 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 2806 | 3969 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 3937 | 3969 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 593 | 3969 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 60846 | 3969 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| CHEMBL1069 | 3969 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| DB00177 | 3969 | 110 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 44350499 | 194938 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(OC)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL541992 | 194938 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 7 | 1 | 8 | 4.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(OC)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10388491 | 205116 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 439 | 7 | 2 | 8 | 3.9 | CCCc1nc(C)n2nc(NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL77783 | 205116 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 439 | 7 | 2 | 8 | 3.9 | CCCc1nc(C)n2nc(NC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10388529 | 205508 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.3 | CCCc1nc(C)n2nc(CO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80773 | 205508 | 0 | None | - | 1 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 440 | 7 | 2 | 8 | 3.3 | CCCc1nc(C)n2nc(CO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 1610 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 3941 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 3961 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 590 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL191 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| DB00678 | 2347 | 95 | None | 1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 87218492 | 170905 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 14 | 3 | 5 | 6.4 | CCCCc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4454778 | 170905 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 14 | 3 | 5 | 6.4 | CCCCc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218698 | 172289 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4474870 | 172289 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| 25190005 | 174037 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 545 | 12 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1cc(F)c(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4543532 | 174037 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 545 | 12 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1cc(F)c(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 9846347 | 198637 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 437 | 6 | 2 | 6 | 5.1 | CCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| CHEMBL57907 | 198637 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 437 | 6 | 2 | 6 | 5.1 | CCc1nc2ccccc2c(C(=O)O)c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81146-X | |||
| 44350543 | 96692 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(F)(F)F)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL264003 | 96692 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(F)(F)F)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10340697 | 104746 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 396 | 6 | 1 | 7 | 3.5 | CCCc1ncn2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL310678 | 104746 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 396 | 6 | 1 | 7 | 3.5 | CCCc1ncn2ncnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 155529942 | 171476 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 569 | 15 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(CC)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4463575 | 171476 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 569 | 15 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(CC)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155547799 | 173688 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4535256 | 173688 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218352 | 174422 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 567 | 13 | 3 | 5 | 7.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4552884 | 174422 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 567 | 13 | 3 | 5 | 7.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 45488150 | 197020 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.4 | CCCc1nc2c(C)cccc2n1Cc1ccc(OCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL567054 | 197020 | 0 | None | - | 1 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.4 | CCCc1nc2c(C)cccc2n1Cc1ccc(OCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 25141240 | 183593 | 0 | None | - | 1 | Pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 10 | 1 | 5 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(-c2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480122 | 183593 | 0 | None | - | 1 | Pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 10 | 1 | 5 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(-c2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10410991 | 204951 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.1 | CCCc1nc(C)n2c(=O)n(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76421 | 204951 | 0 | None | - | 1 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.1 | CCCc1nc(C)n2c(=O)n(C)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 24828743 | 96168 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 788 | 20 | 8 | 9 | 1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| CHEMBL260622 | 96168 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 788 | 20 | 8 | 9 | 1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| 19029649 | 17943 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C(F)(F)F)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL125964 | 17943 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 535 | 6 | 1 | 7 | 5.2 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccc(C(F)(F)F)cc2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10457973 | 14683 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 482 | 9 | 1 | 5 | 6.2 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1205756 | 14683 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 482 | 9 | 1 | 5 | 6.2 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL145036 | 14683 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 482 | 9 | 1 | 5 | 6.2 | CCCCC1=NC(C)(C)C(C(=O)OCC)=C(Cl)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1076629 | 208482 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||||
| 9895957 | 10673 | 18 | None | -3 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| CHEMBL11706 | 10673 | 18 | None | -3 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| 9982165 | 205463 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 470 | 8 | 2 | 9 | 2.6 | CCCc1nc(C)n2c(=O)n(CCO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80446 | 205463 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 470 | 8 | 2 | 9 | 2.6 | CCCc1nc(C)n2c(=O)n(CCO)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 18950387 | 14568 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204443 | 14568 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1790055 | 14568 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(CO)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 44283773 | 14614 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 588 | 12 | 1 | 9 | 5.1 | CCCCc1nc(Cl)c(C(=O)OCC(=O)N(CC)CC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204974 | 14614 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 588 | 12 | 1 | 9 | 5.1 | CCCCc1nc(Cl)c(C(=O)OCC(=O)N(CC)CC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2021415 | 14614 | 0 | None | - | 1 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 588 | 12 | 1 | 9 | 5.1 | CCCCc1nc(Cl)c(C(=O)OCC(=O)N(CC)CC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 87218658 | 171010 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 14 | 3 | 5 | 6.7 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4456544 | 171010 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 14 | 3 | 5 | 6.7 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87219028 | 171601 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 509 | 12 | 3 | 6 | 5.2 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4465325 | 171601 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 509 | 12 | 3 | 6 | 5.2 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 44567816 | 190345 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 492 | 9 | 1 | 6 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL517685 | 190345 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 492 | 9 | 1 | 6 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44567780 | 192184 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 10 | 2 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL520421 | 192184 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 10 | 2 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 9910978 | 14609 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 437 | 8 | 1 | 6 | 5.2 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)oc2c1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204954 | 14609 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 437 | 8 | 1 | 6 | 5.2 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)oc2c1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL36259 | 14609 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 437 | 8 | 1 | 6 | 5.2 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)oc2c1 | 10.1016/S0960-894X(01)81137-9 | |||
| 168275495 | 190471 | 0 | None | -66 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5178838 | 190471 | 0 | None | -66 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10251334 | 205002 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 416 | 7 | 2 | 6 | 4.4 | CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL76775 | 205002 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 416 | 7 | 2 | 6 | 4.4 | CCCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00041a016 | |||
| 155533580 | 171876 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4469350 | 171876 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218397 | 171153 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4458683 | 171153 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10077050 | 85276 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 586 | 8 | 0 | 8 | 7.1 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)OC)cc2C(=O)OC)cc1 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL2260198 | 85276 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 586 | 8 | 0 | 8 | 7.1 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)OC)cc2C(=O)OC)cc1 | 10.1007/s00044-008-9153-9 | |||
| 10100370 | 103174 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 4.2 | CCCc1nc(CCC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL308138 | 103174 | 0 | None | - | 1 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 4.2 | CCCc1nc(CCC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 15657894 | 207093 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 7 | 3 | 7 | 3.2 | CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00070a012 | |||
| CHEMBL1202852 | 207093 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 7 | 3 | 7 | 3.2 | CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00070a012 | |||
| CHEMBL91953 | 207093 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 7 | 3 | 7 | 3.2 | CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00070a012 | |||
| 9805192 | 90955 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL239393 | 90955 | 0 | None | - | 1 | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 19029619 | 18506 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2F)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL127343 | 18506 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 485 | 6 | 1 | 7 | 4.3 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2F)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 44284094 | 14613 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 531 | 11 | 1 | 8 | 6.0 | CCCCOC(=O)c1c(Cl)nc(CCCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204972 | 14613 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 531 | 11 | 1 | 8 | 6.0 | CCCCOC(=O)c1c(Cl)nc(CCCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079782 | 14613 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 531 | 11 | 1 | 8 | 6.0 | CCCCOC(=O)c1c(Cl)nc(CCCC)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 155512629 | 169653 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 563 | 15 | 3 | 5 | 7.0 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4437331 | 169653 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 563 | 15 | 3 | 5 | 7.0 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 168270996 | 190059 | 0 | None | -64 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5172324 | 190059 | 0 | None | -64 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 168287782 | 191824 | 0 | None | -22 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5198739 | 191824 | 0 | None | -22 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 18950379 | 14578 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1ccc2c(ccn2-c2ccccc2C(=O)O)c1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204547 | 14578 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1ccc2c(ccn2-c2ccccc2C(=O)O)c1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL287065 | 14578 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1ccc2c(ccn2-c2ccccc2C(=O)O)c1 | 10.1016/S0960-894X(01)81137-9 | |||
| 18950381 | 14579 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1cccc2c1ccn2-c1ccccc1C(=O)O | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204548 | 14579 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1cccc2c1ccn2-c1ccccc1C(=O)O | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL288691 | 14579 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 403 | 8 | 2 | 5 | 4.4 | CCCCc1ncc(CO)n1Cc1cccc2c1ccn2-c1ccccc1C(=O)O | 10.1016/S0960-894X(01)81137-9 | |||
| 9806325 | 14608 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 509 | 8 | 2 | 7 | 5.1 | CCCCc1nc(C(F)(F)F)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204952 | 14608 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 509 | 8 | 2 | 7 | 5.1 | CCCCc1nc(C(F)(F)F)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL4524049 | 14608 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 509 | 8 | 2 | 7 | 5.1 | CCCCc1nc(C(F)(F)F)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 155513439 | 169730 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 589 | 13 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)c2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4438435 | 169730 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 589 | 13 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)c2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155565351 | 175577 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 575 | 13 | 3 | 5 | 6.7 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4579452 | 175577 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 575 | 13 | 3 | 5 | 6.7 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 19029624 | 18040 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| CHEMBL126490 | 18040 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 481 | 6 | 1 | 7 | 4.5 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2cccc(C)c2)s1 | 10.1016/S0960-894X(97)00026-7 | |||
| 10252591 | 205136 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 4.4 | CCCc1nc(C)n2nc(CC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL78021 | 205136 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 4.4 | CCCc1nc(C)n2nc(CC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 9935424 | 14681 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 5.3 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1205739 | 14681 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 5.3 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL141659 | 14681 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 5.3 | CCCCC1=NC(Cl)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm00103a014 | |||
| 163409135 | 190183 | 3 | None | 37 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5174180 | 190183 | 3 | None | 37 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | |||
| 10254899 | 206895 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 4.2 | CCCCC(=O)N(Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| CHEMBL90834 | 206895 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 4.2 | CCCCC(=O)N(Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| 11488492 | 93501 | 0 | None | - | 1 | Pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CN(C)C(C)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL246255 | 93501 | 0 | None | - | 1 | Pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CN(C)C(C)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44284306 | 14775 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 631 | 11 | 1 | 10 | 6.8 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1206588 | 14775 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 631 | 11 | 1 | 10 | 6.8 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL2079781 | 14775 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 631 | 11 | 1 | 10 | 6.8 | CCCCc1nc(Cl)c(C(=O)OC(OC(=O)C(C)(C)C)C(C)C)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 10884983 | 38308 | 0 | None | -1 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL146275 | 38308 | 0 | None | -1 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 10884983 | 38308 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL146275 | 38308 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| 10093827 | 204907 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 424 | 5 | 2 | 8 | 3.5 | Cc1nc(C2CC2)c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(O)nn12 | 10.1021/jm00041a016 | |||
| CHEMBL76079 | 204907 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 424 | 5 | 2 | 8 | 3.5 | Cc1nc(C2CC2)c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(O)nn12 | 10.1021/jm00041a016 | |||
| 9980359 | 14809 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 9 | 1 | 6 | 4.2 | CCCCc1ncc(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL1207054 | 14809 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 9 | 1 | 6 | 4.2 | CCCCc1ncc(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL342287 | 14809 | 0 | None | - | 1 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 9 | 1 | 6 | 4.2 | CCCCc1ncc(C(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 18950396 | 14569 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 631 | 8 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1c(Br)c(Br)n2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL1204444 | 14569 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 631 | 8 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1c(Br)c(Br)n2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| CHEMBL4524048 | 14569 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 631 | 8 | 2 | 7 | 6.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1c(Br)c(Br)n2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | |||
| 10459016 | 36817 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 510 | 10 | 1 | 5 | 6.8 | CCCCC1=NC(c2ccccc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL145017 | 36817 | 0 | None | - | 1 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 510 | 10 | 1 | 5 | 6.8 | CCCCC1=NC(c2ccccc2)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 10368569 | 205454 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 3.9 | CCCc1nc(C)n2nc(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80380 | 205454 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 3.9 | CCCc1nc(C)n2nc(CC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 127034038 | 139197 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3785563 | 139197 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787702 | 139197 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 10480064 | 111772 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 475 | 9 | 2 | 6 | 4.5 | CCCCC(=O)N(Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| CHEMBL328738 | 111772 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 475 | 9 | 2 | 6 | 4.5 | CCCCC(=O)N(Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| 10027183 | 164252 | 0 | None | - | 1 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 458 | 7 | 2 | 9 | 3.9 | CCCc1nc(SC)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL421141 | 164252 | 0 | None | - | 1 | Rat | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 458 | 7 | 2 | 9 | 3.9 | CCCc1nc(SC)n2c(O)nnc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 168270075 | 190053 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 541 | 8 | 1 | 9 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2nc(CC(C)C)sc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5172242 | 190053 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 541 | 8 | 1 | 9 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2nc(CC(C)C)sc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 44567884 | 183009 | 0 | None | - | 1 | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 524 | 11 | 1 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(Oc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL479367 | 183009 | 0 | None | - | 1 | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 524 | 11 | 1 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(Oc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10348903 | 105411 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 456 | 8 | 2 | 9 | 3.4 | CCCc1nc(COC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL311825 | 105411 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 456 | 8 | 2 | 9 | 3.4 | CCCc1nc(COC)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 145946191 | 167532 | 0 | None | -1096 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 1165 | 26 | 5 | 14 | 4.5 | CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 | 10.1021/jm401789v | |||
| CHEMBL3234454 | 167532 | 0 | None | -1096 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 1165 | 26 | 5 | 14 | 4.5 | CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 | 10.1021/jm401789v | |||
| CHEMBL4300168 | 167532 | 0 | None | -1096 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 1165 | 26 | 5 | 14 | 4.5 | CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 | 10.1021/jm401789v | |||
| 10369660 | 205416 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 528 | 10 | 1 | 10 | 4.5 | CCCc1nc(C)n2nc(SCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| CHEMBL80161 | 205416 | 0 | None | - | 1 | Rat | 7.0 | pKi | = | 7 | Binding | ChEMBL | 528 | 10 | 1 | 10 | 4.5 | CCCc1nc(C)n2nc(SCC(=O)OCC)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | |||
| 10456328 | 34768 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 448 | 9 | 1 | 5 | 5.7 | CCCCC1=NC(C)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| CHEMBL143083 | 34768 | 0 | None | - | 1 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 448 | 9 | 1 | 5 | 5.7 | CCCCC1=NC(C)=C(C(=O)OCC)C(C)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00103a014 | |||
| 4823 | 93562 | 91 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | None | |||
| CHEMBL24646 | 93562 | 91 | None | - | 0 | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | None | |||
| 1610 | 2347 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 2347 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 2347 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 2347 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 2347 | 95 | None | - | 4 | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 1610 | 2347 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 2347 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 2347 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 2347 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 2347 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 2347 | 95 | None | - | 4 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 2806 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 3937 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 593 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 60846 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL1069 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| DB00177 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 2583 | 3776 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 592 | 3776 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999 | 3776 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| DB00966 | 3776 | 118 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 36736 | 3474 | 0 | None | 5 | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 598 | 3474 | 0 | None | 5 | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 6324663 | 3474 | 0 | None | 5 | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL356431 | 3474 | 0 | None | 5 | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 1037 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 3940 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 5281037 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 588 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| DB00876 | 1578 | 69 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 2806 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 3937 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 593 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 60846 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL1069 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| DB00177 | 3969 | 110 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 1037 | 1578 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 3940 | 1578 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 5281037 | 1578 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 588 | 1578 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| DB00876 | 1578 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 2540 | 4401 | 111 | None | - | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| CHEMBL1014 | 4401 | 111 | None | - | 4 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| 2583 | 3776 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 592 | 3776 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999 | 3776 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| DB00966 | 3776 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 16133225 | 419 | 52 | None | - | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 172198 | 419 | 52 | None | - | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 2504 | 419 | 52 | None | - | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 45266664 | 419 | 52 | None | - | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 5272 | 419 | 52 | None | - | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL408403 | 419 | 52 | None | - | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| DB11842 | 419 | 52 | None | - | 4 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 16133225 | 419 | 52 | None | -14 | 4 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 172198 | 419 | 52 | None | -14 | 4 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 2504 | 419 | 52 | None | -14 | 4 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 45266664 | 419 | 52 | None | -14 | 4 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 5272 | 419 | 52 | None | -14 | 4 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL408403 | 419 | 52 | None | -14 | 4 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| DB11842 | 419 | 52 | None | -14 | 4 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | None | None | None | None | None | |||||
| 1610 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 2541 | 786 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| 587 | 786 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| 6907 | 786 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| CHEMBL1016 | 786 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| DB00796 | 786 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| DB13919 | 786 | 120 | None | -1 | 6 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| 6916 | 3483 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 6914 | 3484 | 0 | None | - | 1 | Human | 6.5 | pKd | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 12949261 | |||||
| 6903 | 3480 | 0 | None | - | 1 | Rat | 7.1 | pKd | = | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 10066768 | |||||
| 6903 | 3480 | 0 | None | - | 1 | Rat | 7.1 | pKd | = | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 3082475 | 3877 | 16 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | None | None | None | None | 20801892 | |||||
| 6902 | 3877 | 16 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | None | None | None | None | 20801892 | |||||
| CHEMBL4297447 | 3877 | 16 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | None | None | None | None | 20801892 | |||||
| DB12199 | 3877 | 16 | None | - | 1 | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | None | None | None | None | 20801892 | |||||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 6915 | 3479 | 0 | None | - | 1 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 1037 | 1578 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 3940 | 1578 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 5281037 | 1578 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 588 | 1578 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| CHEMBL813 | 1578 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| DB00876 | 1578 | 69 | None | - | 1 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 6904 | 3481 | 0 | None | - | 1 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 10066768 | |||||
| 6904 | 3481 | 0 | None | - | 1 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 6905 | 3485 | 0 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| None | 216164 | 0 | 125I-Angiotensin II | - | 1 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 395 | 4 | 1 | 6 | 4.4 | CCC1=NC2=C(N1C3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)N=C(C=C2C)C | None | |||
| 16133225 | 419 | 52 | 125I-Angiotensin II | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 172198 | 419 | 52 | 125I-Angiotensin II | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 2504 | 419 | 52 | 125I-Angiotensin II | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 45266664 | 419 | 52 | 125I-Angiotensin II | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 5272 | 419 | 52 | 125I-Angiotensin II | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| CHEMBL408403 | 419 | 52 | 125I-Angiotensin II | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| DB11842 | 419 | 52 | 125I-Angiotensin II | -2 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 36736 | 3474 | 0 | 125I-Angiotensin II | 5 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 598 | 3474 | 0 | 125I-Angiotensin II | 5 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 6324663 | 3474 | 0 | 125I-Angiotensin II | 5 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| CHEMBL356431 | 3474 | 0 | 125I-Angiotensin II | 5 | 3 | Rat | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | None | None | None | None | None | |||||
| 179 | 400 | 115 | 3H-angiotensin II | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 2159 | 400 | 115 | 3H-angiotensin II | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 963 | 400 | 115 | 3H-angiotensin II | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| CHEMBL243712 | 400 | 115 | 3H-angiotensin II | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| DB06288 | 400 | 115 | 3H-angiotensin II | -4365 | 49 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 369 | 7 | 2 | 6 | 1.3 | CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC | None | |||
| 135398737 | 958 | 93 | 3H-angiotensin II | -4168 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 958 | 93 | 3H-angiotensin II | -4168 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 958 | 93 | 3H-angiotensin II | -4168 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 958 | 93 | 3H-angiotensin II | -4168 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 958 | 93 | 3H-angiotensin II | -4168 | 89 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 1353 | 1911 | 93 | 3H-angiotensin II | -6918 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 1911 | 93 | 3H-angiotensin II | -6918 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 1911 | 93 | 3H-angiotensin II | -6918 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 1911 | 93 | 3H-angiotensin II | -6918 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 1911 | 93 | 3H-angiotensin II | -6918 | 83 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 1973 | 203483 | 15 | 125I-[SAR1, ILe8]-AII | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
| CHEMBL1394464 | 203483 | 15 | 125I-[SAR1, ILe8]-AII | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
| CHEMBL66089 | 203483 | 15 | 125I-[SAR1, ILe8]-AII | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | |||
| 1610 | 2347 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 2347 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 2347 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 2347 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 2347 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 2347 | 95 | 125I-Angiotensin II | -1 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| None | 216163 | 0 | 125I-Angiotensin II | - | 1 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 424 | 10 | 2 | 5 | 4.7 | CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)C=C(CC3=CC=CS3)C(=O)O | None | |||
| 2806 | 3969 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 3937 | 3969 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 593 | 3969 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 60846 | 3969 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL1069 | 3969 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| DB00177 | 3969 | 110 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 1610 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3941 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 2347 | 95 | None | -1 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 1481 | 2066 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 3749 | 2066 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 589 | 2066 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 6908 | 2066 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| CHEMBL1513 | 2066 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| DB01029 | 2066 | 116 | None | -1 | 3 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 1481 | 2066 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 3749 | 2066 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 589 | 2066 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 6908 | 2066 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| CHEMBL1513 | 2066 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| DB01029 | 2066 | 116 | None | 1 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 2540 | 4401 | 111 | None | -1 | 4 | Rabbit | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| CHEMBL1014 | 4401 | 111 | None | -1 | 4 | Rabbit | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| 16133225 | 419 | 52 | None | -2 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 172198 | 419 | 52 | None | -2 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 2504 | 419 | 52 | None | -2 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 45266664 | 419 | 52 | None | -2 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 5272 | 419 | 52 | None | -2 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL408403 | 419 | 52 | None | -2 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| DB11842 | 419 | 52 | None | -2 | 4 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 1056 | 3371 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| 2405 | 3371 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| 77999 | 3371 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| CHEMBL121 | 3371 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| DB00412 | 3371 | 116 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| 2583 | 3776 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 592 | 3776 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999 | 3776 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| CHEMBL1017 | 3776 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| DB00966 | 3776 | 118 | None | - | 1 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 36736 | 3474 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 598 | 3474 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 6324663 | 3474 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| CHEMBL356431 | 3474 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | |||||
| 11944 | 3876 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| 155552190 | 3876 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| CHEMBL4544228 | 3876 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| 11943 | 3875 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| 145925549 | 3875 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| CHEMBL4438122 | 3875 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 30639099 | |||||
| 11930 | 1019 | 0 | None | -537 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 15780052 | 1019 | 0 | None | -537 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| CHEMBL289472 | 1019 | 0 | None | -537 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 11931 | 1065 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 126456406 | 1065 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 6894 | 418 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 21464395 | |||||
| 91691124 | 418 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 21464395 | |||||
| 136218976 | 150 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | |||
| 6913 | 150 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | |||
| 60921 | 3469 | 0 | None | - | 1 | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| 6899 | 3469 | 0 | None | - | 1 | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| CHEMBL305544 | 3469 | 0 | None | - | 1 | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| DB01347 | 3469 | 0 | None | - | 1 | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| 10257882 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||
| 8448 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||
| CHEMBL539423 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||
| DB12548 | 3646 | 43 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||